# emapper version: emapper-2.0.1 emapper DB: 2.0
#
# time: Thu Apr 13 20:52:01 2023
#query_name	seed_eggNOG_ortholog	seed_ortholog_evalue	seed_ortholog_score	best_tax_level	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	taxonomic scope	eggNOG OGs	best eggNOG OG	COG Functional cat.	eggNOG free text desc.
C1_00001	155864.EDL933_4351	2.5e-92	344.7	Escherichia	agaR	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141		ko:K02081,ko:K02436,ko:K02468					ko00000,ko03000				Bacteria	1MUJT@1224,1SZXU@1236,3XPHU@561,COG1349@1,COG1349@2	NA|NA|NA	K	repressor for the aga operon for N-acetyl galactosamine transport and metabolism
C1_00002	481805.EcolC_0570	3e-86	324.3	Escherichia	yhaV	GO:0001558,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0030308,GO:0034641,GO:0040008,GO:0043021,GO:0043023,GO:0043170,GO:0044237,GO:0044238,GO:0044877,GO:0045926,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360		ko:K19155					ko00000,ko01000,ko02048				Bacteria	1Q4H5@1224,1S3G4@1236,28N0M@1,2ZB6Z@2,3XQ7U@561	NA|NA|NA	K	acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression
C1_00003	316407.85675926	6.2e-57	226.5	Escherichia	sohA	GO:0001558,GO:0003674,GO:0003700,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0040008,GO:0042802,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097351,GO:0140110,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K19156					ko00000,ko02048				Bacteria	1RIAX@1224,1SC9R@1236,3XRA1@561,COG2002@1,COG2002@2	NA|NA|NA	K	Antitoxin component of a type II toxin-antitoxin (TA) system. Labile antitoxin that binds to the YhaV toxin and neutralizes its ribonuclease activity. Also acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression
C1_00004	469008.B21_02944	2.4e-284	984.2	Escherichia	garD	GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0008867,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019577,GO:0019579,GO:0019580,GO:0019752,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046392,GO:0046395,GO:0071704,GO:1901575	4.2.1.42,4.2.1.7	ko:K01685,ko:K01708	ko00040,ko00053,ko01100,map00040,map00053,map01100	M00631	R01540,R05608	RC00543	ko00000,ko00001,ko00002,ko01000			iECED1_1282.ECED1_3790,iECP_1309.ECP_3218,iLF82_1304.LF82_0803,iNRG857_1313.NRG857_15535,iYO844.BSU02510	Bacteria	1MU9V@1224,1RP0M@1236,3XMT0@561,COG2721@1,COG2721@2	NA|NA|NA	E	Catalyzes the dehydration of galactarate to form 5- dehydro-4-deoxy-D-glucarate
C1_00005	155864.EDL933_4346	8.6e-251	872.5	Escherichia	garP	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0015711,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0044425,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944		ko:K03535,ko:K12299					ko00000,ko02000	2.A.1.14.1,2.A.1.14.14		iSF_1195.SF3164,iSFxv_1172.SFxv_3474,iSSON_1240.SSON_2946,iS_1188.S3379	Bacteria	1MVPS@1224,1RNMV@1236,3XNY3@561,COG2271@1,COG2271@2	NA|NA|NA	P	galactarate transporter
C1_00006	155864.EDL933_4345	3.8e-142	510.8	Escherichia	garL	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0008672,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016830,GO:0016832,GO:0017144,GO:0019392,GO:0019394,GO:0019577,GO:0019579,GO:0019580,GO:0019752,GO:0042737,GO:0042836,GO:0042838,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046392,GO:0046395,GO:0071704,GO:1901575	4.1.2.20,4.1.2.52,4.1.2.53	ko:K01630,ko:K02510,ko:K12660	ko00051,ko00053,ko00350,ko01120,map00051,map00053,map00350,map01120		R01645,R01647,R02261,R02754,R03277	RC00307,RC00435,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_3301,iE2348C_1286.E2348C_3412,iEC042_1314.EC042_3416,iEC55989_1330.EC55989_3544,iECIAI1_1343.ECIAI1_3274,iECIAI39_1322.ECIAI39_3625,iECNA114_1301.ECNA114_3207,iECO103_1326.ECO103_3871,iECO26_1355.ECO26_4229,iECOK1_1307.ECOK1_3549,iECP_1309.ECP_3216,iECS88_1305.ECS88_3514,iECSE_1348.ECSE_3410,iECSF_1327.ECSF_2962,iECUMN_1333.ECUMN_3608,iECW_1372.ECW_m3394,iECs_1301.ECs4004,iEKO11_1354.EKO11_0593,iEcE24377_1341.EcE24377A_3604,iEcSMS35_1347.EcSMS35_3421,iG2583_1286.G2583_3848,iLF82_1304.LF82_0805,iNRG857_1313.NRG857_15525,iSBO_1134.SBO_2049,iSBO_1134.SBO_2991,iUMN146_1321.UM146_00720,iUTI89_1310.UTI89_C3557,iWFL_1372.ECW_m3394,iZ_1308.Z4478	Bacteria	1MUSG@1224,1RMWJ@1236,3XMGU@561,COG3836@1,COG3836@2	NA|NA|NA	G	Catalyzes the reversible retro-aldol cleavage of both 5- keto-4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdehyde
C1_00007	199310.c3880	2.8e-157	561.2	Escherichia	garR	GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0008679,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0019392,GO:0019394,GO:0019577,GO:0019579,GO:0019580,GO:0019752,GO:0042737,GO:0042836,GO:0042838,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046392,GO:0046395,GO:0055114,GO:0071704,GO:1901575	1.1.1.60	ko:K00042	ko00630,ko01100,map00630,map01100		R01745,R01747	RC00099	ko00000,ko00001,ko01000			iNRG857_1313.NRG857_15520	Bacteria	1MUGU@1224,1SYGG@1236,3XP63@561,COG2084@1,COG2084@2	NA|NA|NA	I	Catalyzes the reduction of tatronate semialdehyde to D- glycerate
C1_00008	198214.SF3161	1.7e-210	738.4	Gammaproteobacteria	glxK	GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016301,GO:0016310,GO:0016491,GO:0016661,GO:0016662,GO:0016740,GO:0016772,GO:0017144,GO:0019392,GO:0019394,GO:0019577,GO:0019579,GO:0019580,GO:0019752,GO:0042737,GO:0042836,GO:0042838,GO:0043436,GO:0043648,GO:0043649,GO:0043798,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046392,GO:0046395,GO:0055114,GO:0071704,GO:1901575	2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130		R08572	RC00002,RC00428	ko00000,ko00001,ko01000			iECs_1301.ECs4002,iG2583_1286.G2583_3846	Bacteria	1MVG9@1224,1RMC6@1236,COG1929@1,COG1929@2	NA|NA|NA	G	Belongs to the glycerate kinase type-1 family
C1_00009	637910.ROD_00481	4e-160	570.9	Gammaproteobacteria	piv			ko:K07486					ko00000				Bacteria	1MXKJ@1224,1RSCP@1236,COG3547@1,COG3547@2	NA|NA|NA	L	Transposase
C1_00013	155864.EDL933_4339	9.9e-169	599.4	Escherichia	tdcA	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141		ko:K07592,ko:K14057					ko00000,ko03000				Bacteria	1R6CD@1224,1RSEB@1236,3XNVP@561,COG0583@1,COG0583@2	NA|NA|NA	K	Transcriptional regulator
C1_00014	155864.EDL933_4338	4.8e-182	643.7	Escherichia	tdcB	GO:0003674,GO:0003824,GO:0003941,GO:0004793,GO:0004794,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006563,GO:0006565,GO:0006566,GO:0006567,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016597,GO:0016829,GO:0016830,GO:0016832,GO:0016840,GO:0016841,GO:0019752,GO:0019842,GO:0030170,GO:0031406,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	4.3.1.15,4.3.1.19	ko:K01751,ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_2699,iECED1_1282.ECED1_3331	Bacteria	1MVWJ@1224,1RPGU@1236,3XMXP@561,COG1171@1,COG1171@2	NA|NA|NA	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C1_00015	199310.c3874	5e-243	846.7	Escherichia	tdcC	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015077,GO:0015078,GO:0015171,GO:0015175,GO:0015179,GO:0015194,GO:0015195,GO:0015238,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015672,GO:0015711,GO:0015804,GO:0015807,GO:0015825,GO:0015826,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022889,GO:0022890,GO:0031224,GO:0031226,GO:0032329,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:1902475,GO:1902600,GO:1903825,GO:1905039		ko:K03834,ko:K03835,ko:K03836,ko:K03837,ko:K03838					ko00000,ko02000	2.A.42.1.1,2.A.42.1.2,2.A.42.1.3,2.A.42.2.1,2.A.42.2.2		iAPECO1_1312.APECO1_3308,iE2348C_1286.E2348C_3406,iEC55989_1330.EC55989_3533,iEC55989_1330.EC55989_3581,iECABU_c1320.ECABU_c35330,iECED1_1282.ECED1_3781,iECIAI1_1343.ECIAI1_3265,iECNA114_1301.ECNA114_4343,iECO103_1326.ECO103_3863,iECO103_1326.ECO103_3910,iECO111_1330.ECO111_3985,iECO26_1355.ECO26_4221,iECO26_1355.ECO26_4267,iECOK1_1307.ECOK1_3543,iECP_1309.ECP_3209,iECSE_1348.ECSE_3400,iECSE_1348.ECSE_3447,iECSF_1327.ECSF_2956,iECUMN_1333.ECUMN_2202,iECW_1372.ECW_m3385,iEKO11_1354.EKO11_0601,iEcE24377_1341.EcE24377A_3643,iLF82_1304.LF82_2232,iNRG857_1313.NRG857_15495,iSBO_1134.SBO_2981,iSDY_1059.SDY_3013,iSFV_1184.SFV_3804,iSFxv_1172.SFxv_4080,iSSON_1240.SSON_3307,iS_1188.S4018,iSbBS512_1146.SbBS512_E3241,iUMN146_1321.UM146_00750,iUTI89_1310.UTI89_C3551,iWFL_1372.ECW_m3385,ic_1306.c3874	Bacteria	1QB56@1224,1RMJ8@1236,3XP6Z@561,COG0814@1,COG0814@2	NA|NA|NA	E	Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system)
C1_00016	469008.B21_02933	6.6e-226	789.6	Escherichia	ackA	GO:0003674,GO:0003824,GO:0006082,GO:0006091,GO:0006113,GO:0006520,GO:0006566,GO:0006567,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008776,GO:0008980,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009987,GO:0015980,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019665,GO:0019666,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.7.2.1,2.7.2.15	ko:K00925,ko:K00932	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_3309,iECS88_1305.ECS88_3508,iEcSMS35_1347.EcSMS35_3411,iLF82_1304.LF82_2233,iSDY_1059.SDY_2492,iUTI89_1310.UTI89_C3550	Bacteria	1MW61@1224,1RMKB@1236,3XPDE@561,COG0282@1,COG0282@2	NA|NA|NA	F	Catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP
C1_00017	316407.85675912	0.0	1535.8	Escherichia	pflB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006566,GO:0006567,GO:0006629,GO:0006631,GO:0006807,GO:0008150,GO:0008152,GO:0008861,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009987,GO:0016020,GO:0016054,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0016999,GO:0017144,GO:0019541,GO:0019752,GO:0032787,GO:0042737,GO:0043436,GO:0043875,GO:0044237,GO:0044238,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046459,GO:0070689,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120		R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000			iECH74115_1262.ECH74115_1064,iECIAI39_1322.ECIAI39_2245,iECSP_1301.ECSP_1007,iECs_1301.ECs0986,iEcSMS35_1347.EcSMS35_2218,iEcSMS35_1347.EcSMS35_3410,iG2583_1286.G2583_1138,iSDY_1059.SDY_2358,iZ_1308.Z1248	Bacteria	1MWYE@1224,1RWKK@1236,3XMIN@561,COG1882@1,COG1882@2	NA|NA|NA	C	formate acetyltransferase
C1_00018	155864.EDL933_4334	3.6e-64	250.8	Escherichia	tdcF	GO:0003674,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009987,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605	3.5.99.10	ko:K09022			R11098,R11099	RC03275,RC03354	ko00000,ko01000				Bacteria	1MZ3J@1224,1S5XS@1236,3XPIQ@561,COG0251@1,COG0251@2	NA|NA|NA	E	May be a post-translational regulator that controls the metabolic fate of L-threonine or the potentially toxic intermediate 2-ketobutyrate
C1_00019	316407.85675910	3.9e-259	900.2	Escherichia	sdaA	GO:0003674,GO:0003824,GO:0003941,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006563,GO:0006565,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016829,GO:0016840,GO:0016841,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	4.3.1.17	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230		R00220,R00590	RC00331,RC02600	ko00000,ko00001,ko01000			iECSP_1301.ECSP_4084,iECUMN_1333.ECUMN_2106	Bacteria	1MUZN@1224,1RMJZ@1236,3XNG8@561,COG1760@1,COG1760@2	NA|NA|NA	E	L-serine ammonia-lyase activity
C1_00020	511145.b3110	4.9e-238	830.1	Escherichia	yhaO	GO:0000096,GO:0000098,GO:0001101,GO:0003333,GO:0003674,GO:0005215,GO:0005300,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008152,GO:0008324,GO:0008509,GO:0008514,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009093,GO:0009314,GO:0009628,GO:0009987,GO:0010033,GO:0010243,GO:0015075,GO:0015077,GO:0015078,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015194,GO:0015195,GO:0015196,GO:0015238,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015672,GO:0015711,GO:0015801,GO:0015804,GO:0015807,GO:0015825,GO:0015826,GO:0015827,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0016054,GO:0019752,GO:0022804,GO:0022857,GO:0022889,GO:0022890,GO:0031224,GO:0031226,GO:0032329,GO:0034220,GO:0042221,GO:0042493,GO:0042940,GO:0042942,GO:0043200,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0044425,GO:0044459,GO:0044464,GO:0046395,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:1901367,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901698,GO:1901700,GO:1902475,GO:1902600,GO:1903825,GO:1905039		ko:K03834,ko:K03835,ko:K03836,ko:K03837,ko:K03838					ko00000,ko02000	2.A.42.1.1,2.A.42.1.2,2.A.42.1.3,2.A.42.2.1,2.A.42.2.2		iAPECO1_1312.APECO1_3308,iE2348C_1286.E2348C_3406,iEC55989_1330.EC55989_3533,iEC55989_1330.EC55989_3581,iECABU_c1320.ECABU_c35330,iECED1_1282.ECED1_3781,iECIAI1_1343.ECIAI1_3265,iECNA114_1301.ECNA114_4343,iECO103_1326.ECO103_3863,iECO103_1326.ECO103_3910,iECO111_1330.ECO111_3985,iECO26_1355.ECO26_4221,iECO26_1355.ECO26_4267,iECOK1_1307.ECOK1_3543,iECP_1309.ECP_3209,iECSE_1348.ECSE_3400,iECSE_1348.ECSE_3447,iECSF_1327.ECSF_2956,iECUMN_1333.ECUMN_2202,iECW_1372.ECW_m3385,iEKO11_1354.EKO11_0601,iEcE24377_1341.EcE24377A_3643,iLF82_1304.LF82_2232,iNRG857_1313.NRG857_15495,iSBO_1134.SBO_2981,iSDY_1059.SDY_3013,iSFV_1184.SFV_3804,iSFxv_1172.SFxv_4080,iSSON_1240.SSON_3307,iS_1188.S4018,iSbBS512_1146.SbBS512_E3241,iUMN146_1321.UM146_00750,iUTI89_1310.UTI89_C3551,iWFL_1372.ECW_m3385,ic_1306.c3874	Bacteria	1N3PB@1224,1RQXP@1236,3XM8X@561,COG0814@1,COG0814@2	NA|NA|NA	E	Plays a role in L-cysteine detoxification. May transport both D- and L-serine (By similarity)
C1_00021	155864.EDL933_4331	3.8e-235	820.5	Escherichia	yhaM	GO:0000096,GO:0000098,GO:0001101,GO:0003674,GO:0003824,GO:0006082,GO:0006090,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009093,GO:0009987,GO:0010033,GO:0010243,GO:0016054,GO:0016829,GO:0016846,GO:0019448,GO:0019450,GO:0019752,GO:0032787,GO:0042221,GO:0043200,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0046395,GO:0046439,GO:0050896,GO:0071704,GO:0080146,GO:1901367,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901698,GO:1901700											Bacteria	1MW81@1224,1RP1R@1236,3XNM0@561,COG3681@1,COG3681@2	NA|NA|NA	S	UPF0597 protein YhaM
C1_00022	155864.EDL933_4330	1.6e-18	97.8	Escherichia	yhaL												Bacteria	1NIFB@1224,1SGPP@1236,2EMRY@1,33FED@2,3XQ3G@561	NA|NA|NA		
C1_00023	316407.85675906	3e-130	471.1	Escherichia	yhaK	GO:0003674,GO:0003824,GO:0008127,GO:0008150,GO:0008152,GO:0016491,GO:0016701,GO:0016702,GO:0051213,GO:0055114		ko:K06911					ko00000				Bacteria	1MWSY@1224,1RMSK@1236,3XMRG@561,COG1741@1,COG1741@2	NA|NA|NA	S	Belongs to the pirin family
C1_00024	1440052.EAKF1_ch2826	3.5e-163	580.9	Escherichia	yhaJ	GO:0001130,GO:0001216,GO:0003674,GO:0003700,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2000142,GO:2000144,GO:2001141											Bacteria	1MZTA@1224,1RN7R@1236,3XMMI@561,COG0583@1,COG0583@2	NA|NA|NA	K	transcriptional regulator
C1_00025	155864.EDL933_4327	2.9e-52	211.1	Escherichia	yhaI	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1MZJ4@1224,1SA1N@1236,3XPKE@561,COG3152@1,COG3152@2	NA|NA|NA	S	Protein of unknown function (DUF805)
C1_00026	155864.EDL933_4326	2.6e-69	267.7	Escherichia	yhaH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1MZJ4@1224,1SA1N@1236,3XPKE@561,COG3152@1,COG3152@2	NA|NA|NA	S	Protein of unknown function (DUF805)
C1_00027	198214.SF3145	3.7e-198	697.2	Gammaproteobacteria	yqjG	GO:0003674,GO:0003824,GO:0004364,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0016491,GO:0016667,GO:0016672,GO:0016740,GO:0016765,GO:0042221,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.8.5.7,2.5.1.18	ko:K00799,ko:K07393	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418		R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2		iECW_1372.ECW_m3373,iWFL_1372.ECW_m3373	Bacteria	1MV50@1224,1RMTI@1236,COG0435@1,COG0435@2	NA|NA|NA	O	Glutathione S-Transferase
C1_00028	155864.EDL933_4324	7.2e-65	253.1	Escherichia	yqjF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K15977					ko00000				Bacteria	1MZVP@1224,1S8UI@1236,3XPNK@561,COG2259@1,COG2259@2	NA|NA|NA	S	DoxX
C1_00029	155864.EDL933_4323	6.1e-48	196.4	Escherichia	yqjK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Bacteria	1N7E9@1224,1SCW7@1236,2E52J@1,32ZVT@2,3XPY4@561	NA|NA|NA	S	YqjK-like protein
C1_00030	155864.EDL933_4322	1.1e-60	239.2	Escherichia	yqjE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1RHS9@1224,1S5UU@1236,3XPK8@561,COG5393@1,COG5393@2	NA|NA|NA	S	Putative Actinobacterial Holin-X, holin superfamily III
C1_00031	155864.EDL933_4321	8.4e-45	186.0	Escherichia	yqjD	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0043021,GO:0043024,GO:0044464,GO:0044877,GO:0060187,GO:0071944		ko:K05594,ko:K07184					ko00000				Bacteria	1N6X7@1224,1S9QF@1236,3XPV7@561,COG4575@1,COG4575@2	NA|NA|NA	S	ribosome binding
C1_00032	155864.EDL933_4320	6.8e-49	199.9	Escherichia	yqjC												Bacteria	1NAAB@1224,1SE1J@1236,3XPQR@561,COG1422@1,COG1422@2	NA|NA|NA	S	Protein of unknown function (DUF1090)
C1_00033	316407.85675896	1.4e-65	255.4	Escherichia	mzrA	GO:0001932,GO:0008150,GO:0019220,GO:0019222,GO:0031323,GO:0031399,GO:0032268,GO:0042325,GO:0043549,GO:0045859,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051174,GO:0051246,GO:0051338,GO:0060255,GO:0065007,GO:0065009,GO:0080090											Bacteria	1RFWN@1224,1S4DF@1236,2E956@1,333DY@2,3XPRQ@561	NA|NA|NA	S	Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR
C1_00034	155864.EDL933_4318	1.6e-117	428.7	Escherichia	yqjA	GO:0000003,GO:0000910,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0022857,GO:0032505,GO:0043093,GO:0044464,GO:0051179,GO:0051234,GO:0051301,GO:0055085,GO:0071944											Bacteria	1MU30@1224,1RNS5@1236,3XPA0@561,COG0586@1,COG0586@2	NA|NA|NA	S	Inner membrane protein YqjA
C1_00035	155864.EDL933_4316	3.7e-145	520.8	Escherichia	exuR	GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K05799,ko:K13637,ko:K19775					ko00000,ko03000				Bacteria	1MY44@1224,1RN58@1236,3XM90@561,COG2186@1,COG2186@2	NA|NA|NA	K	Repressor for the exu regulon that encode genes involved in hexuronate utilization. It regulates the ExuT, UxaCA and UxuRAB operons. Binds D-tagaturonate and D-fructuronate as inducers
C1_00036	481805.EcolC_0603	2.7e-126	458.0	Gammaproteobacteria	cblB												Bacteria	1RGBA@1224,1S5QN@1236,COG3121@1,COG3121@2	NA|NA|NA	NU	Chaperone
C1_00037	481805.EcolC_0604	1.2e-80	305.8	Gammaproteobacteria	cblA												Bacteria	1RKK0@1224,1S8E0@1236,2AZ6I@1,31RDB@2	NA|NA|NA	S	CS1 type fimbrial major subunit
C1_00038	481805.EcolC_0605	0.0	1744.9	Gammaproteobacteria	cblC			ko:K07347,ko:K21966	ko05133,map05133				ko00000,ko00001,ko02000,ko02035,ko02044	1.B.11.3			Bacteria	1PTRC@1224,1S047@1236,COG3188@1,COG3188@2	NA|NA|NA	NU	E-set like domain
C1_00039	362663.ECP_3185	8.5e-164	583.2	Gammaproteobacteria	tcfD												Bacteria	1RE92@1224,1S5DK@1236,2A77P@1,30W3V@2	NA|NA|NA	S	CblD family pilus biogenesis initiator protein
C1_00040	469008.B21_02913	1.1e-239	835.5	Escherichia	exuT	GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008028,GO:0008150,GO:0008509,GO:0008514,GO:0008643,GO:0015075,GO:0015133,GO:0015134,GO:0015144,GO:0015145,GO:0015318,GO:0015711,GO:0015718,GO:0015735,GO:0015736,GO:0015749,GO:0015778,GO:0015849,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0034219,GO:0034220,GO:0044425,GO:0044464,GO:0046942,GO:0046943,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098656,GO:1903825,GO:1905039		ko:K08191					ko00000,ko02000	2.A.1.14.2		iBWG_1329.BWG_2803,iEC55989_1330.EC55989_3507,iECDH10B_1368.ECDH10B_3269,iECDH1ME8569_1439.ECDH1ME8569_2988,iECIAI39_1322.ECIAI39_3590,iECSP_1301.ECSP_4067,iECs_1301.ECs3975,iETEC_1333.ETEC_3363,iG2583_1286.G2583_3817,iZ_1308.Z4446	Bacteria	1MV04@1224,1RP70@1236,3XNJH@561,COG2271@1,COG2271@2	NA|NA|NA	P	Hexuronate transporter
C1_00041	198214.SF3132	1.1e-280	971.8	Gammaproteobacteria	uxaC	GO:0005975,GO:0005996,GO:0006063,GO:0006064,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0019585,GO:0019586,GO:0019698,GO:0019752,GO:0032787,GO:0042839,GO:0042840,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046365,GO:0046395,GO:0046396,GO:0046397,GO:0071704,GO:0072329,GO:1901575	5.3.1.12	ko:K01812	ko00040,ko01100,map00040,map01100	M00061,M00631	R01482,R01983	RC00376	ko00000,ko00001,ko00002,ko01000			iPC815.YPO0579,iSbBS512_1146.SbBS512_E3528	Bacteria	1MVRI@1224,1RMRR@1236,COG1904@1,COG1904@2	NA|NA|NA	G	glucuronate isomerase
C1_00042	316407.85675891	1.4e-289	1001.5	Escherichia	uxaA	GO:0003674,GO:0005488,GO:0005506,GO:0005975,GO:0005996,GO:0006063,GO:0006082,GO:0008150,GO:0008152,GO:0008198,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0019586,GO:0019698,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046365,GO:0046395,GO:0046396,GO:0046397,GO:0046872,GO:0046914,GO:0071704,GO:0072329,GO:1901575	4.2.1.7	ko:K01685	ko00040,ko01100,map00040,map01100	M00631	R01540	RC00543	ko00000,ko00001,ko00002,ko01000			iECO103_1326.ECO103_3836	Bacteria	1MU9V@1224,1RP0M@1236,3XMJR@561,COG2721@1,COG2721@2	NA|NA|NA	G	altronate dehydratase activity
C1_00043	155864.EDL933_4312	6.1e-102	376.7	Escherichia	ygjV	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944											Bacteria	1N283@1224,1S26U@1236,28NVI@1,2ZBTK@2,3XMDF@561	NA|NA|NA	S	Bacterial inner membrane protein
C1_00044	155864.EDL933_4311	1.2e-219	768.8	Escherichia	sstT	GO:0003333,GO:0003674,GO:0005215,GO:0005283,GO:0005295,GO:0005310,GO:0005342,GO:0005343,GO:0005416,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006820,GO:0006835,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015077,GO:0015081,GO:0015171,GO:0015175,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015672,GO:0015711,GO:0015804,GO:0015849,GO:0016020,GO:0016021,GO:0017153,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0032329,GO:0034220,GO:0035725,GO:0044425,GO:0044464,GO:0046873,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:1903825,GO:1905039		ko:K07862					ko00000,ko02000	2.A.23.4		iAF1260.b3089,iBWG_1329.BWG_2799,iECDH10B_1368.ECDH10B_3265,iECDH1ME8569_1439.ECDH1ME8569_2984,iECH74115_1262.ECH74115_4404,iECIAI1_1343.ECIAI1_3235,iECO103_1326.ECO103_3834,iECO111_1330.ECO111_3911,iECO26_1355.ECO26_4192,iECP_1309.ECP_3180,iECSE_1348.ECSE_3370,iECSP_1301.ECSP_4063,iECUMN_1333.ECUMN_3573,iECW_1372.ECW_m3356,iECs_1301.ECs3971,iEKO11_1354.EKO11_0630,iETEC_1333.ETEC_3359,iEcDH1_1363.EcDH1_0612,iEcE24377_1341.EcE24377A_3557,iG2583_1286.G2583_3813,iJO1366.b3089,iJR904.b3089,iSFV_1184.SFV_3130,iSSON_1240.SSON_3242,iUMNK88_1353.UMNK88_3845,iWFL_1372.ECW_m3356,iY75_1357.Y75_RS16050,iYL1228.KPN_03517,iZ_1308.Z4442	Bacteria	1MXE1@1224,1RP9B@1236,3XM7S@561,COG3633@1,COG3633@2	NA|NA|NA	E	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C1_00045	316407.85675888	6.8e-173	613.2	Escherichia	alx	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K05794					ko00000				Bacteria	1MUNR@1224,1RP9Y@1236,3XN6B@561,COG0861@1,COG0861@2	NA|NA|NA	P	Has been proposed to be a redox modulator
C1_00046	469008.B21_02906	4.1e-181	640.6	Escherichia	ygjR	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0055114,GO:0102497		ko:K22230	ko00562,ko01120,map00562,map01120		R09954	RC00182	ko00000,ko00001,ko01000				Bacteria	1MZIG@1224,1RS5T@1236,3XM6C@561,COG0673@1,COG0673@2	NA|NA|NA	S	oxidoreductase activity
C1_00047	481805.EcolC_0614	3.9e-122	444.1	Escherichia	ygjQ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016021,GO:0031224,GO:0044425,GO:0044464,GO:0071944		ko:K03748					ko00000				Bacteria	1R5Q2@1224,1RZK7@1236,3XQJ9@561,COG2949@1,COG2949@2	NA|NA|NA	S	DUF218 domain
C1_00048	155864.EDL933_4307	4e-92	344.0	Escherichia	ygjP			ko:K07043					ko00000				Bacteria	1RDJ9@1224,1S45M@1236,3XNWK@561,COG1451@1,COG1451@2	NA|NA|NA	S	Specifically catalyzes the hydrolysis of UTP to UMP and diphosphate in vitro, albeit at apparently slow rate. Shows no activity towards ATP, GTP, CTP, dTTP and ITP as substrates
C1_00049	199310.c3842	1.1e-217	762.3	Escherichia	rlmG	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052916,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.172,2.1.1.174	ko:K00564,ko:K11391			R07234	RC00003	ko00000,ko01000,ko03009				Bacteria	1NEMR@1224,1RMXE@1236,3XMGF@561,COG2813@1,COG2813@2	NA|NA|NA	J	Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA
C1_00050	198214.SF3122	8.8e-69	266.2	Gammaproteobacteria	higA	GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141		ko:K18831					ko00000,ko02048,ko03000				Bacteria	1RBYR@1224,1S260@1236,COG5499@1,COG5499@2	NA|NA|NA	K	transcriptional regulator
C1_00051	316407.85675881	0.0	1328.5	Escherichia	fadH	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0008670,GO:0009056,GO:0009062,GO:0009987,GO:0010181,GO:0016042,GO:0016054,GO:0016491,GO:0016627,GO:0016628,GO:0019395,GO:0019752,GO:0030258,GO:0032553,GO:0032787,GO:0033542,GO:0033543,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071949,GO:0072329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901575	1.3.1.34	ko:K00219					ko00000,ko01000				Bacteria	1MVE0@1224,1RNM8@1236,3XNUV@561,COG0446@1,COG0446@2,COG1902@1,COG1902@2	NA|NA|NA	C	Functions as an auxiliary enzyme in the beta-oxidation of unsaturated fatty acids with double bonds at even carbon positions. Catalyzes the NADPH-dependent reduction of the C4-C5 double bond of the acyl chain of 2,4-dienoyl-CoA to yield 2-trans- enoyl-CoA. Acts on both isomers, 2-trans,4-cis- and 2-trans,4-trans-decadienoyl-CoA, with almost equal efficiency. Is not active with NADH instead of NADPH. Does not show cis- trans isomerase activity
C1_00052	469008.B21_02899	0.0	1620.5	Escherichia	ygjK	GO:0003674,GO:0003824,GO:0004553,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0015926,GO:0016787,GO:0016798,GO:0033554,GO:0050896,GO:0051716	3.2.1.28	ko:K01194,ko:K03931	ko00500,ko01100,map00500,map01100		R00010	RC00049	ko00000,ko00001,ko00537,ko01000		GH37,GH63	iAF1260.b1197,iB21_1397.B21_01182,iBWG_1329.BWG_1022,iECBD_1354.ECBD_2425,iECB_1328.ECB_01172,iECDH10B_1368.ECDH10B_1250,iECDH1ME8569_1439.ECDH1ME8569_1136,iECD_1391.ECD_01172,iETEC_1333.ETEC_1301,iEcDH1_1363.EcDH1_2451,iEcHS_1320.EcHS_A1301,iEcolC_1368.EcolC_2429,iJO1366.b1197,iJR904.b1197,iSBO_1134.SBO_3518,iY75_1357.Y75_RS06245	Bacteria	1MXU9@1224,1RRDG@1236,3XMCX@561,COG1626@1,COG1626@2,COG3408@1,COG3408@2	NA|NA|NA	G	Glucoside hydrolase that cleaves the alpha-1,3- glucosidic linkage in nigerose. Has very low activity towards maltooligosaccharides, soluble starch, nigerotriose, kojibiose and trehalose
C1_00053	316407.85675879	3.6e-215	753.8	Escherichia	ygjJ												Bacteria	1R4J1@1224,1RYGU@1236,28HKS@1,2Z7VJ@2,3XN5X@561	NA|NA|NA		
C1_00054	155864.EDL933_4300	1.7e-260	904.8	Escherichia	ygjI	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K20265	ko02024,map02024				ko00000,ko00001,ko02000	2.A.3.7.1,2.A.3.7.3		iEC042_1314.EC042_1624	Bacteria	1MWXV@1224,1RPPM@1236,3XQFH@561,COG0531@1,COG0531@2	NA|NA|NA	E	transmembrane transporter activity
C1_00055	199310.c3834	1.4e-80	305.4	Escherichia	ebgC			ko:K12112,ko:K19334	ko00052,ko00511,ko01100,map00052,map00511,map01100		R01678	RC00049	ko00000,ko00001,ko02048				Bacteria	1RGW2@1224,1S72G@1236,3XPHG@561,COG2731@1,COG2731@2	NA|NA|NA	G	Required for full activity of the EbgA enzyme. Exact function not known
C1_00056	155864.EDL933_4298	0.0	2153.3	Escherichia	ebgA	GO:0003674,GO:0003824,GO:0004553,GO:0004565,GO:0005575,GO:0005975,GO:0005984,GO:0005988,GO:0005990,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009341,GO:0009987,GO:0015925,GO:0016052,GO:0016787,GO:0016798,GO:0032991,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0046352,GO:0071704,GO:1901575,GO:1902494	3.2.1.23	ko:K01190,ko:K12111	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100		R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000				Bacteria	1MVBN@1224,1RMER@1236,3XN5C@561,COG3250@1,COG3250@2	NA|NA|NA	G	lactose catabolic process
C1_00057	316407.85675875	2.8e-182	644.4	Escherichia	ebgR	GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K02529,ko:K12113					ko00000,ko03000				Bacteria	1N8ZA@1224,1RSGV@1236,3XP3T@561,COG1609@1,COG1609@2	NA|NA|NA	K	Transcriptional regulator EbgR
C1_00058	155864.EDL933_4296	8.3e-54	216.1	Escherichia	ygjH	GO:0000049,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0017101,GO:0017102,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.10,6.1.1.20	ko:K01874,ko:K01890,ko:K06878	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R03660,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iEC042_1314.EC042_2346,iECUMN_1333.ECUMN_2446	Bacteria	1QUBK@1224,1S46T@1236,3XPT5@561,COG0073@1,COG0073@2	NA|NA|NA	J	tRNA aminoacylation for protein translation
C1_00059	155864.EDL933_4295	7.5e-244	849.4	Escherichia	patA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009056,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009987,GO:0016740,GO:0016769,GO:0019842,GO:0030170,GO:0033094,GO:0034641,GO:0036094,GO:0042402,GO:0042802,GO:0043167,GO:0043168,GO:0044106,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:0097164,GO:1901363,GO:1901564,GO:1901565,GO:1901575	2.6.1.11,2.6.1.17,2.6.1.82	ko:K00821,ko:K05830,ko:K09251	ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00031,M00763,M00845	R01155,R02283,R04475,R09778,R10932	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007			iECIAI1_1343.ECIAI1_3220,iECSF_1327.ECSF_2916,iECs_1301.ECs3955,iZ_1308.Z4426	Bacteria	1R6U9@1224,1RMRF@1236,3XNZ9@561,COG4992@1,COG4992@2	NA|NA|NA	H	Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. Is also able to transaminate cadaverine and, in lower extent, spermidine, but not ornithine
C1_00060	481805.EcolC_0628	1.4e-241	842.0	Escherichia	aer	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006935,GO:0007154,GO:0007165,GO:0008150,GO:0009453,GO:0009454,GO:0009605,GO:0009987,GO:0016020,GO:0023052,GO:0040011,GO:0042221,GO:0042330,GO:0042802,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0050918,GO:0051716,GO:0052128,GO:0052131,GO:0065007,GO:0071944		ko:K03776	ko02020,ko02030,map02020,map02030				ko00000,ko00001,ko02035				Bacteria	1MU9B@1224,1RMH0@1236,3XMRX@561,COG0840@1,COG0840@2	NA|NA|NA	T	Signal transducer for aerotaxis. The aerotactic response is the accumulation of cells around air bubbles. The nature of the sensory stimulus detected by this protein is the proton motive force or cellular redox state. It uses a FAD prosthetic group as a redox sensor to monitor oxygen levels
C1_00061	198214.SF3112	2.2e-100	371.7	Gammaproteobacteria	yqjI	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141											Bacteria	1RHSE@1224,1S255@1236,COG1695@1,COG1695@2	NA|NA|NA	K	transcriptional regulator
C1_00062	155864.EDL933_4291	1.6e-145	521.9	Escherichia	yqjH	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010045,GO:0016491,GO:0016722,GO:0016723,GO:0019725,GO:0030003,GO:0033212,GO:0036094,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048037,GO:0048878,GO:0050660,GO:0050662,GO:0050801,GO:0050896,GO:0051716,GO:0052851,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071241,GO:0071248,GO:0071289,GO:0071949,GO:0097159,GO:0098771,GO:1901265,GO:1901363	1.16.1.9	ko:K07229					ko00000,ko01000				Bacteria	1R4TD@1224,1RY01@1236,3XMHN@561,COG2375@1,COG2375@2	NA|NA|NA	P	ferric-chelate reductase (NADPH) activity
C1_00064	199310.c3822	1.5e-91	342.0	Escherichia	mug	GO:0000700,GO:0003674,GO:0003824,GO:0004844,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008263,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360	3.2.2.28,6.3.3.2	ko:K01934,ko:K03649	ko00670,ko01100,ko03410,map00670,map01100,map03410		R02301	RC00183	ko00000,ko00001,ko01000,ko03400				Bacteria	1R47B@1224,1T0RJ@1236,3XMG7@561,COG3663@1,COG3663@2	NA|NA|NA	L	Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells
C1_00065	155864.EDL933_4289	0.0	1123.2	Escherichia	rpoD	GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141		ko:K03086					ko00000,ko03021				Bacteria	1MVNJ@1224,1RMQI@1236,3XPCE@561,COG0568@1,COG0568@2	NA|NA|NA	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
C1_00066	155864.EDL933_4287	0.0	1164.8	Escherichia	dnaG	GO:0003674,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576		ko:K02316	ko03030,map03030				ko00000,ko00001,ko01000,ko03032				Bacteria	1MUHC@1224,1RMGA@1236,3XNFD@561,COG0358@1,COG0358@2	NA|NA|NA	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
C1_00067	1005994.GTGU_04164	6e-29	132.9	Gammaproteobacteria	rpsU	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02970	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1MZCC@1224,1S8QZ@1236,COG0828@1,COG0828@2	NA|NA|NA	J	Belongs to the bacterial ribosomal protein bS21 family
C1_00068	198214.SF3105	9.3e-189	666.0	Gammaproteobacteria	tsaD	GO:0000287,GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140030,GO:0140032,GO:0140096,GO:1901360,GO:1901564	2.3.1.234	ko:K01409,ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	R10648	RC00070,RC00416	ko00000,ko00001,ko00002,ko01000,ko02044,ko03016	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4			Bacteria	1MU6S@1224,1RN8M@1236,COG0533@1,COG0533@2	NA|NA|NA	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C1_00069	155864.EDL933_4284	5e-268	929.9	Escherichia	ttdT	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0015291,GO:0015297,GO:0016020,GO:0022804,GO:0022857,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944		ko:K03319,ko:K09477,ko:K11106	ko02020,map02020				ko00000,ko00001,ko02000	2.A.47,2.A.47.3.2,2.A.47.3.3		iAF1260.b3063,iBWG_1329.BWG_2774,iECDH10B_1368.ECDH10B_3238,iECDH1ME8569_1439.ECDH1ME8569_2959,iECIAI1_1343.ECIAI1_3211,iETEC_1333.ETEC_3334,iEcDH1_1363.EcDH1_0637,iEcolC_1368.EcolC_0636,iJO1366.b3063,iJR904.b3063,iSSON_1240.SSON_0564,iUMNK88_1353.UMNK88_3815,iY75_1357.Y75_RS15915	Bacteria	1MUSA@1224,1RMF3@1236,3XQHR@561,COG0471@1,COG0471@2	NA|NA|NA	P	Catalyzes the uptake of tartrate in exchange for intracellular succinate. Essential for anaerobic L-tartrate fermentation
C1_00070	198214.SF3103	4.5e-114	417.2	Gammaproteobacteria	ttdB	GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0050896	4.2.1.2,4.2.1.32	ko:K01676,ko:K01678,ko:K03780	ko00020,ko00620,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00630,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00339,R01082	RC00443,RC01382	ko00000,ko00001,ko00002,ko01000			iEC55989_1330.EC55989_1778,iSBO_1134.SBO_2920	Bacteria	1MVNG@1224,1RMT4@1236,COG1838@1,COG1838@2	NA|NA|NA	C	)-tartrate dehydratase
C1_00071	316407.85675862	6.6e-170	603.2	Escherichia	ttdA	GO:0008150,GO:0008152,GO:1901275	4.2.1.32	ko:K03779	ko00630,map00630		R00339	RC01382	ko00000,ko00001,ko01000			iLF82_1304.LF82_2330	Bacteria	1MW8J@1224,1RPUD@1236,3XQD3@561,COG1951@1,COG1951@2	NA|NA|NA	C	L( )-tartrate dehydratase subunit alpha
C1_00072	316407.85675861	6.8e-178	629.8	Escherichia	ttdR	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006082,GO:0006108,GO:0006355,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043436,GO:0043565,GO:0043648,GO:0044237,GO:0044281,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141		ko:K16135,ko:K21742					ko00000,ko03000				Bacteria	1MVJ7@1224,1RMNJ@1236,3XPYE@561,COG0583@1,COG0583@2	NA|NA|NA	K	Positive regulator required for L-tartrate-dependent anaerobic growth on glycerol. Induces expression of the ttdA-ttdB- ygjE operon
C1_00073	155864.EDL933_4280	3.3e-112	411.0	Escherichia	plsY	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004				Bacteria	1RD4Z@1224,1RN1J@1236,3XP9Z@561,COG0344@1,COG0344@2	NA|NA|NA	I	Catalyzes the transfer of an acyl group from acyl-ACP to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme can also utilize acyl-CoA as fatty acyl donor, but not acyl-PO(4)
C1_00074	198214.SF3099	1.1e-59	235.7	Gammaproteobacteria	folB	GO:0003674,GO:0003824,GO:0004150,GO:0005488,GO:0005515,GO:0016829,GO:0016830,GO:0016832,GO:0042802	1.13.11.81,4.1.2.25,5.1.99.7,5.1.99.8	ko:K01633,ko:K07589	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073,R11082	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000			iECDH1ME8569_1439.ECDH1ME8569_2955,iECSE_1348.ECSE_3338,iPC815.YPO0648,iSBO_1134.SBO_2914,iSDY_1059.SDY_3241,iSFxv_1172.SFxv_3403,iUTI89_1310.UTI89_C3494,iYL1228.KPN_03462,ic_1306.c3808	Bacteria	1MZ8Z@1224,1S9B2@1236,COG1539@1,COG1539@2	NA|NA|NA	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C1_00075	198214.SF3098	1.6e-146	525.4	Gammaproteobacteria	uppP	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016311,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0031224,GO:0031226,GO:0042221,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050380,GO:0050896,GO:0071944	3.6.1.27	ko:K06153	ko00550,map00550		R05627	RC00002	ko00000,ko00001,ko01000,ko01011			iYL1228.KPN_03461	Bacteria	1MX02@1224,1RQQT@1236,COG1968@1,COG1968@2	NA|NA|NA	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
C1_00076	155864.EDL933_4277	6.8e-242	842.8	Escherichia	cca	GO:0001680,GO:0003674,GO:0003824,GO:0004652,GO:0004810,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016437,GO:0016740,GO:0016772,GO:0016779,GO:0031123,GO:0034470,GO:0034641,GO:0034660,GO:0042245,GO:0042780,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0070566,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1990817	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018		R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019				Bacteria	1MU2X@1224,1RPFJ@1236,3XNTY@561,COG0617@1,COG0617@2	NA|NA|NA	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases
C1_00077	362663.ECP_3145	3.4e-109	401.0	Escherichia	ygiM	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0071944		ko:K07184					ko00000				Bacteria	1MX7M@1224,1RS74@1236,3XN08@561,COG3103@1,COG4991@2	NA|NA|NA	T	Bacterial SH3 domain
C1_00078	155864.EDL933_4274	1.6e-246	858.2	Escherichia	ygiF	GO:0003674,GO:0003824,GO:0005488,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0043167,GO:0043169,GO:0046872,GO:0050355	3.6.1.25	ko:K18446					ko00000,ko01000				Bacteria	1MY43@1224,1RMP4@1236,3XMHT@561,COG3025@1,COG3025@2	NA|NA|NA	S	Involved in the hydrolysis of the beta-gamma- phosphoanhydride linkage of triphosphate-containing substrates (inorganic or nucleoside-linked). Catalyzes the hydrolysis of inorganic triphosphate (PPPi), which could be cytotoxic because of its high affinity for calcium ion, thereby interfering with calcium signaling. It also hydrolyzes slowly thiamine triphosphate (ThTP). YgiF is a specific PPPase, but it contributes only marginally to the total PPPase activity in E.coli, where the main enzyme responsible for hydrolysis of PPPi is inorganic pyrophosphatase (PPase)
C1_00079	316407.85675854	0.0	1860.1	Escherichia	glnE	GO:0000166,GO:0000287,GO:0000820,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006521,GO:0006541,GO:0006542,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008882,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0010565,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0019222,GO:0019752,GO:0030554,GO:0031323,GO:0032553,GO:0032555,GO:0032559,GO:0033238,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.7.42,2.7.7.89	ko:K00982					ko00000,ko01000				Bacteria	1MU4I@1224,1RP9N@1236,3XP8M@561,COG1391@1,COG1391@2	NA|NA|NA	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell
C1_00080	316407.85675853	7e-267	926.0	Escherichia	hldE	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008219,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0012501,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016779,GO:0019200,GO:0033692,GO:0033785,GO:0033786,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0070566,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.7.1.167,2.7.7.70	ko:K03272,ko:K21344	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005			iECH74115_1262.ECH74115_4363,iECSP_1301.ECSP_4025,iECs_1301.ECs3935,iPC815.YPO0654,iZ_1308.Z4405	Bacteria	1MV3Z@1224,1RMAJ@1236,3XM6T@561,COG0615@1,COG0615@2,COG2870@1,COG2870@2	NA|NA|NA	F	belongs to the carbohydrate kinase PfkB family
C1_00081	316407.1805590	2.2e-235	821.6	Escherichia	yqiK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944		ko:K07192	ko04910,map04910				ko00000,ko00001,ko03036,ko04131,ko04147				Bacteria	1P50K@1224,1RRHJ@1236,3XNVI@561,COG2268@1,COG2268@2	NA|NA|NA	S	Flotillin
C1_00082	316407.85675852	4.4e-112	410.6	Escherichia	yuaF	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0033554,GO:0044464,GO:0050896,GO:0051716,GO:0071944											Bacteria	1R4NP@1224,1RQ4X@1236,3XQV3@561,COG1585@1,COG1585@2	NA|NA|NA	OU	cellular response to DNA damage stimulus
C1_00083	316407.1805589	3.1e-32	143.7	Escherichia	glgS	GO:0006109,GO:0008150,GO:0009893,GO:0010675,GO:0010676,GO:0019222,GO:0031323,GO:0031325,GO:0032879,GO:0040012,GO:0040013,GO:0043900,GO:0043901,GO:0045913,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051270,GO:0051271,GO:0065007,GO:0080090,GO:1900190,GO:1900191,GO:1900231,GO:1900232,GO:1902021,GO:1902201,GO:2000145,GO:2000146											Bacteria	1N89V@1224,1SD5E@1236,2CHAW@1,32ZQX@2,3XQ46@561	NA|NA|NA	S	Major determinant of cell surface composition. Negatively regulates motility, adhesion and synthesis of biofilm exopolysaccharides
C1_00084	316407.85675851	3.6e-163	580.9	Escherichia	yqiI	GO:0008150,GO:0010033,GO:0042221,GO:0050896,GO:0051595,GO:1901654,GO:1901700											Bacteria	1R7A3@1224,1S1D9@1236,3XRG6@561,COG3539@1,COG3539@2	NA|NA|NA	NU	Fimbrial protein
C1_00085	481805.EcolC_0652	9.7e-135	486.1	Escherichia	yqiH	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716		ko:K07353,ko:K15540					ko00000,ko02035				Bacteria	1MY06@1224,1RN7Y@1236,3XPFT@561,COG3121@1,COG3121@2	NA|NA|NA	M	chaperone
C1_00086	469008.B21_02866	0.0	1644.8	Escherichia	yqiG	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0009279,GO:0009297,GO:0009987,GO:0015267,GO:0015288,GO:0015473,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0022803,GO:0022829,GO:0022857,GO:0030030,GO:0030031,GO:0030312,GO:0030313,GO:0031975,GO:0043711,GO:0044085,GO:0044462,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071840,GO:0071944											Bacteria	1P744@1224,1RN8Z@1236,3XMSW@561,COG3188@1,COG3188@2	NA|NA|NA	NU	outer membrane usher protein
C1_00087	316407.85675846	4.2e-95	354.0	Escherichia	ygiL			ko:K07345	ko05133,map05133				ko00000,ko00001,ko02035,ko02044				Bacteria	1RC9J@1224,1S359@1236,3XR8P@561,COG3539@1,COG3539@2	NA|NA|NA	NU	cell adhesion
C1_00088	198214.SF3082	1.9e-41	174.9	Gammaproteobacteria	yqiC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K09806					ko00000				Bacteria	1N7AH@1224,1SCH1@1236,COG2960@1,COG2960@2	NA|NA|NA	S	protein conserved in bacteria
C1_00089	155864.EDL933_4267	2.3e-116	424.9	Escherichia	ribB	GO:0000287,GO:0003674,GO:0003824,GO:0003933,GO:0003935,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0008686,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0016829,GO:0016830,GO:0017144,GO:0018130,GO:0019238,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.5.4.25,4.1.99.12	ko:K02858,ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000				Bacteria	1MU8P@1224,1RQ49@1236,3XMEU@561,COG0108@1,COG0108@2	NA|NA|NA	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1_00090	362663.ECP_3135	1.2e-21	108.2	Escherichia													Bacteria	1P90F@1224,1SVXC@1236,2C0YM@1,2ZEYA@2,3XR86@561	NA|NA|NA	S	Protein of unknown function (DUF4051)
C1_00091	155864.EDL933_4265	2.5e-125	454.9	Escherichia	zupT	GO:0000041,GO:0003674,GO:0005215,GO:0005381,GO:0005384,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0006826,GO:0006828,GO:0006829,GO:0008150,GO:0008324,GO:0015075,GO:0015086,GO:0015087,GO:0015093,GO:0015318,GO:0015684,GO:0015691,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0034755,GO:0044464,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070574,GO:0070838,GO:0071421,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:1903874		ko:K07238					ko00000,ko02000	2.A.5.5		iECIAI39_1322.ECIAI39_3536	Bacteria	1MWEZ@1224,1RNXU@1236,3XN1F@561,COG0428@1,COG0428@2	NA|NA|NA	P	Mediates zinc uptake. May also transport other divalent cations
C1_00092	155864.EDL933_4264	1.2e-157	562.4	Escherichia	ygiD	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0046566,GO:0051213,GO:0055114	1.13.11.8	ko:K04100,ko:K15777	ko00362,ko00624,ko00627,ko00965,ko01120,map00362,map00624,map00627,map00965,map01120		R01632,R03550,R04280,R08836,R09565	RC00233,RC00387,RC00535,RC02567,RC02694	br01602,ko00000,ko00001,ko01000				Bacteria	1MXJZ@1224,1RR5P@1236,3XNY6@561,COG3384@1,COG3384@2	NA|NA|NA	S	In vitro, opens the cyclic ring of dihydroxy- phenylalanine (DOPA) between carbons 4 and 5, thus producing an unstable seco-DOPA that rearranges nonenzymatically to betalamic acid. The physiological substrate is
C1_00093	155864.EDL933_4263	6.6e-231	806.2	Escherichia	ygiC		3.5.1.78,6.3.1.8	ko:K01460	ko00480,ko01100,map00480,map01100		R01917,R01918	RC00090,RC00096	ko00000,ko00001,ko01000			iECIAI39_1322.ECIAI39_3484	Bacteria	1MW6V@1224,1RQAP@1236,3XN5K@561,COG0754@1,COG0754@2	NA|NA|NA	E	May be a ligase forming an amide bond. Shows ATPase activity
C1_00094	155864.EDL933_4262	1.7e-117	428.7	Escherichia	ygiB	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944											Bacteria	1MXGU@1224,1RPEV@1236,3XNSY@561,COG5463@1,COG5463@2	NA|NA|NA	S	Protein of unknown function (DUF1190)
C1_00095	316407.85675838	2e-269	934.5	Escherichia	tolC	GO:0002790,GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0008104,GO:0008150,GO:0009279,GO:0009306,GO:0009987,GO:0010033,GO:0014070,GO:0015031,GO:0015075,GO:0015267,GO:0015288,GO:0015318,GO:0015562,GO:0015688,GO:0015711,GO:0015833,GO:0015850,GO:0015891,GO:0015893,GO:0016020,GO:0016021,GO:0019867,GO:0022803,GO:0022829,GO:0022838,GO:0022857,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0032940,GO:0032991,GO:0033036,GO:0034220,GO:0042221,GO:0042493,GO:0042802,GO:0042886,GO:0042930,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0046618,GO:0046903,GO:0047485,GO:0050896,GO:0051179,GO:0051181,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098796,GO:1901678,GO:1902495,GO:1990195,GO:1990196,GO:1990281,GO:1990351		ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821			ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2		iAPECO1_1312.APECO1_3378,iEC042_1314.EC042_3326,iECOK1_1307.ECOK1_3463	Bacteria	1MWCJ@1224,1RQQV@1236,3XMC8@561,COG1538@1,COG1538@2	NA|NA|NA	M	Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells
C1_00096	155864.EDL933_4260	1.5e-112	412.1	Escherichia	nudF	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019144,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0047631,GO:0050896	3.6.1.13	ko:K01515,ko:K12945	ko00230,map00230		R01054	RC00002	ko00000,ko00001,ko01000			iECP_1309.ECP_3126,iUTI89_1310.UTI89_C2793,ic_1306.c2994	Bacteria	1RDMW@1224,1RPZV@1236,3XP8H@561,COG0494@1,COG0494@2	NA|NA|NA	L	Acts on ADP-mannose and ADP-glucose as well as ADP- ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process
C1_00097	1440052.EAKF1_ch2896	1.3e-75	288.9	Escherichia	yqiB			ko:K09920					ko00000				Bacteria	1RA4E@1224,1S55I@1236,3XN24@561,COG3151@1,COG3151@2	NA|NA|NA	S	Protein of unknown function (DUF1249)
C1_00098	155864.EDL933_4258	7.9e-162	576.2	Escherichia	cpdA	GO:0003674,GO:0003824,GO:0004112,GO:0004114,GO:0004115,GO:0005488,GO:0005506,GO:0008081,GO:0008150,GO:0008198,GO:0009987,GO:0016043,GO:0016787,GO:0016788,GO:0042545,GO:0042578,GO:0043167,GO:0043169,GO:0045229,GO:0046872,GO:0046914,GO:0071554,GO:0071555,GO:0071840	2.1.2.2,3.1.4.53	ko:K03651,ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,ko02025,map00230,map00670,map01100,map01110,map01130,map02025	M00048	R00191,R04325,R04326	RC00026,RC00197,RC00296,RC01128	ko00000,ko00001,ko00002,ko01000				Bacteria	1MWKX@1224,1RPA7@1236,3XNUE@561,COG1409@1,COG1409@2	NA|NA|NA	S	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C1_00099	155864.EDL933_4257	1.9e-109	401.7	Escherichia	yqiA	GO:0003674,GO:0003824,GO:0016787,GO:0016788		ko:K07000					ko00000				Bacteria	1MVJF@1224,1S5WF@1236,3XN2H@561,COG3150@1,COG3150@2	NA|NA|NA	S	Displays esterase activity toward palmitoyl-CoA and pNP- butyrate
C1_00100	316407.85675833	0.0	1260.4	Escherichia	parE	GO:0000819,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0022402,GO:0030541,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0098813,GO:0140097,GO:1901360	5.99.1.3	ko:K02470,ko:K02622					ko00000,ko01000,ko02048,ko03032,ko03036,ko03400				Bacteria	1MVH1@1224,1RMCI@1236,3XND7@561,COG0187@1,COG0187@2	NA|NA|NA	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
C1_00101	155864.EDL933_4249	6.6e-53	213.0	Escherichia	ygiN	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0009268,GO:0009628,GO:0010447,GO:0016491,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0055114										iEcSMS35_1347.EcSMS35_3317	Bacteria	1RE0B@1224,1S3QV@1236,3XPV5@561,COG1359@1,COG1359@2	NA|NA|NA	S	Can oxidize menadiol to menadione
C1_00102	155864.EDL933_4248	2e-111	408.3	Escherichia	mdaB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008753,GO:0016491,GO:0016651,GO:0016655,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0097159,GO:1901265,GO:1901363		ko:K03923,ko:K11746,ko:K11748					ko00000,ko02000	2.A.37.1.1,2.A.37.1.2		iLF82_1304.LF82_1283	Bacteria	1MWV9@1224,1RQ16@1236,3XP9N@561,COG2249@1,COG2249@2	NA|NA|NA	S	Modulator of drug activity B
C1_00103	316407.85675830	4.1e-53	213.8	Gammaproteobacteria	ygiZ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1N8VS@1224,1SFKV@1236,2E4JB@1,32ZED@2	NA|NA|NA	S	Protein of unknown function (DUF2645)
C1_00104	155864.EDL933_4247	1.5e-247	861.7	Escherichia	qseC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.13.3	ko:K07643,ko:K07645,ko:K07653,ko:K18351	ko01502,ko01503,ko02020,ko02024,map01502,map01503,map02020,map02024	M00451,M00453,M00460,M00651,M00658,M00721,M00722			ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022				Bacteria	1QTSX@1224,1T1G3@1236,3XN9X@561,COG0642@1,COG0642@2	NA|NA|NA	T	Member of a two-component regulatory system QseB QseC. Activates the flagella regulon by activating transcription of FlhDC. May activate QseB by phosphorylation
C1_00105	155864.EDL933_4246	1.6e-120	438.7	Escherichia													Bacteria	1N0YI@1224,1RQQ3@1236,3XP78@561,COG0745@1,COG0745@2	NA|NA|NA	K	Member of a two-component regulatory system QseB QseC. Activates the flagella regulon by activating transcription of FlhDC. Currently it is not known whether this effect is direct or not
C1_00106	155864.EDL933_4245	1.8e-60	238.4	Escherichia	ygiW	GO:0000302,GO:0006950,GO:0006979,GO:0008150,GO:0009636,GO:0009987,GO:0010035,GO:0010038,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042710,GO:0044010,GO:0044011,GO:0044764,GO:0046677,GO:0046686,GO:0050896,GO:0051703,GO:0051704,GO:0051716,GO:0070301,GO:0070887,GO:0071236,GO:0071241,GO:0071248,GO:0071276,GO:0090605,GO:0090609,GO:0097237,GO:1901700,GO:1901701											Bacteria	1N9HJ@1224,1SCD7@1236,3XPMM@561,COG3111@1,COG3111@2	NA|NA|NA	S	cellular response to cadmium ion
C1_00107	316407.85675826	1.2e-88	332.4	Escherichia	ygiV	GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K07471,ko:K13652					ko00000,ko03000				Bacteria	1QTW6@1224,1T2QK@1236,3XPFY@561,COG3449@1,COG3449@2	NA|NA|NA	K	transcriptional regulator
C1_00109	155864.EDL933_4242	0.0	1460.3	Escherichia	parC	GO:0000819,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008150,GO:0008152,GO:0009330,GO:0009987,GO:0016020,GO:0016043,GO:0019897,GO:0019898,GO:0022402,GO:0030541,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0098813,GO:1901360,GO:1901363	5.99.1.3	ko:K02469,ko:K02621					ko00000,ko01000,ko02048,ko03032,ko03036,ko03400				Bacteria	1MURI@1224,1RMTC@1236,3XNES@561,COG0188@1,COG0188@2	NA|NA|NA	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
C1_00110	198214.SF3062	7.8e-137	493.0	Gammaproteobacteria	plsC	GO:0003674,GO:0003824,GO:0003841,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0042171,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071617,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.3.1.51,3.1.3.3	ko:K00655,ko:K07003,ko:K15781	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004				Bacteria	1MY51@1224,1RQYC@1236,COG0204@1,COG0204@2	NA|NA|NA	I	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family
C1_00111	155864.EDL933_4240	6.3e-276	956.1	Escherichia	ftsP	GO:0005575,GO:0005623,GO:0006950,GO:0006979,GO:0008150,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0042597,GO:0044464,GO:0050896,GO:0051301		ko:K04753,ko:K14588					ko00000			iECH74115_1262.ECH74115_0130,iECSP_1301.ECSP_0124	Bacteria	1MU0J@1224,1RN7I@1236,3XNVT@561,COG2132@1,COG2132@2	NA|NA|NA	D	Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress
C1_00112	316407.85675819	0.0	1521.1	Escherichia	ygiQ												Bacteria	1MUG3@1224,1RN9V@1236,3XN2Q@561,COG1032@1,COG1032@2	NA|NA|NA	C	UPF0313 protein YgiQ
C1_00113	155864.EDL933_4238	4.5e-39	166.8	Escherichia	lpp			ko:K06078					ko00000,ko01011				Bacteria	1NYPN@1224,1SPTJ@1236,3XQ1X@561,COG4238@1,COG4238@2	NA|NA|NA	M	Lipoprotein leucine-zipper
C1_00114	155864.EDL933_4237	1e-116	426.0	Escherichia	yqhG												Bacteria	1RKYU@1224,1S8BB@1236,2C67P@1,32RGV@2,3XPG9@561	NA|NA|NA	S	Protein of unknown function (DUF3828)
C1_00115	316407.85675817	5.7e-13	79.3	Escherichia	yqhG												Bacteria	1RKYU@1224,1S8BB@1236,2C67P@1,32RGV@2,3XPG9@561	NA|NA|NA	S	Protein of unknown function (DUF3828)
C1_00116	316407.85675816	8.2e-159	566.2	Escherichia	dkgA	GO:0003674,GO:0003824,GO:0004033,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0008106,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0042180,GO:0042182,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0051596,GO:0055114,GO:0071704,GO:1901575	1.1.1.346	ko:K06221			R08878	RC00089	ko00000,ko01000			iECH74115_1262.ECH74115_4323,iECSP_1301.ECSP_3988	Bacteria	1MWFS@1224,1RMX6@1236,3XMUT@561,COG0656@1,COG0656@2	NA|NA|NA	S	Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG)
C1_00117	316407.85675815	1.9e-222	778.1	Escherichia	yqhD	GO:0000302,GO:0003674,GO:0003824,GO:0004033,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008106,GO:0008150,GO:0008152,GO:0008270,GO:0016491,GO:0016614,GO:0016616,GO:0018455,GO:0042221,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0055114,GO:1901700,GO:1990002		ko:K00100,ko:K08325,ko:K19955	ko00640,ko00650,ko01120,map00640,map00650,map01120		R02528,R03544,R03545	RC00087,RC00739	ko00000,ko00001,ko01000				Bacteria	1QUBJ@1224,1RP7C@1236,3XP5X@561,COG1979@1,COG1979@2	NA|NA|NA	C	alcohol dehydrogenase [NAD(P)+] activity
C1_00118	198214.SF3056	4.5e-177	627.1	Gammaproteobacteria	yqhC	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141											Bacteria	1MUEM@1224,1RQQK@1236,COG2207@1,COG2207@2	NA|NA|NA	K	transcriptional regulator
C1_00119	155864.EDL933_4230	1.6e-117	428.7	Escherichia	yghB	GO:0000003,GO:0000910,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0019954,GO:0022402,GO:0022414,GO:0022857,GO:0031224,GO:0031226,GO:0032505,GO:0043093,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0051301,GO:0055085,GO:0071944											Bacteria	1N2EF@1224,1RQKN@1236,3XM2J@561,COG0586@1,COG0586@2	NA|NA|NA	S	inner membrane protein YghB
C1_00120	316407.85675812	9.4e-225	785.8	Escherichia	metC	GO:0000096,GO:0000097,GO:0000098,GO:0003674,GO:0003824,GO:0003962,GO:0004121,GO:0004123,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006090,GO:0006520,GO:0006534,GO:0006555,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009067,GO:0009069,GO:0009071,GO:0009086,GO:0009093,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019448,GO:0019450,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046395,GO:0046439,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	2.5.1.48,4.4.1.11,4.4.1.8	ko:K01739,ko:K01760,ko:K01761	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00654,R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04941,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000			iAF1260.b3939,iBWG_1329.BWG_3608,iECDH10B_1368.ECDH10B_4128,iECDH1ME8569_1439.ECDH1ME8569_3808,iETEC_1333.ETEC_4208,iEcDH1_1363.EcDH1_4046,iEcHS_1320.EcHS_A4172,iEcolC_1368.EcolC_4076,iJO1366.b3939,iJR904.b3939,iSbBS512_1146.SbBS512_E3435,iUMNK88_1353.UMNK88_4777,iUTI89_1310.UTI89_C3428,iY75_1357.Y75_RS17365	Bacteria	1MU9E@1224,1RQI0@1236,3XPCU@561,COG0626@1,COG0626@2	NA|NA|NA	E	cystathionine beta-lyase
C1_00121	155864.EDL933_4228	2.6e-124	451.4	Escherichia	exbB	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0023052,GO:0031224,GO:0031226,GO:0031647,GO:0031992,GO:0032991,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050794,GO:0050821,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0065008,GO:0071944,GO:0098796,GO:0098797		ko:K03561,ko:K03562	ko01120,map01120				ko00000,ko02000	1.A.30.2.1,1.A.30.2.2		iSBO_1134.SBO_3000,iSbBS512_1146.SbBS512_E3434	Bacteria	1MXHR@1224,1RND2@1236,3XNK7@561,COG0811@1,COG0811@2	NA|NA|NA	U	Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. Protects ExbD from proteolytic degradation and functionally stabilizes TonB
C1_00122	155864.EDL933_4227	9.6e-71	272.7	Escherichia	exbD	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0023052,GO:0031224,GO:0031226,GO:0031647,GO:0031992,GO:0032991,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050794,GO:0050821,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0065008,GO:0071944,GO:0098796,GO:0098797		ko:K03559,ko:K03560					ko00000,ko02000	1.A.30.2.1,1.A.30.2.2		iPC815.YPO0683	Bacteria	1MZ6M@1224,1S82I@1236,3XP84@561,COG0848@1,COG0848@2	NA|NA|NA	U	Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates
C1_00123	155864.EDL933_4225	1.3e-162	578.9	Escherichia													Bacteria	1MW9A@1224,1RMC9@1236,3XNMH@561,COG1028@1,COG1028@2	NA|NA|NA	IQ	alcohol dehydrogenase (NADP+) activity
C1_00124	155864.EDL933_4224	4.4e-83	313.9	Escherichia	yqhA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03535					ko00000,ko02000	2.A.1.14.1			Bacteria	1RANN@1224,1S2DE@1236,3XP73@561,COG2862@1,COG2862@2	NA|NA|NA	S	Uncharacterized protein family, UPF0114
C1_00125	198214.SF3047	2.7e-199	701.0	Gammaproteobacteria	yghZ	GO:0003674,GO:0003824,GO:0006081,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0033554,GO:0042180,GO:0042182,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046185,GO:0050896,GO:0051596,GO:0051716,GO:0055114,GO:0071704,GO:1901575		ko:K19265					ko00000,ko01000			iSBO_1134.SBO_2995	Bacteria	1MU1S@1224,1RMIG@1236,COG0667@1,COG0667@2	NA|NA|NA	C	reductase
C1_00126	362663.ECP_3085	1.9e-169	601.7	Escherichia	yghX		3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130		R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000				Bacteria	1MW7S@1224,1RPGK@1236,3XMUE@561,COG0412@1,COG0412@2	NA|NA|NA	Q	X-Pro dipeptidyl-peptidase (S15 family)
C1_00127	155864.EDL933_4221	1.8e-49	201.4	Escherichia	yghW	GO:0001101,GO:0008150,GO:0010033,GO:0042221,GO:0050896,GO:0097305,GO:1901422,GO:1901700											Bacteria	1RHHT@1224,1S71B@1236,2CFWY@1,31RXH@2,3XPZR@561	NA|NA|NA	S	response to butan-1-ol
C1_00128	155864.EDL933_4219	3.6e-218	763.8	Escherichia	hybO	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0009897,GO:0009986,GO:0016020,GO:0019897,GO:0019898,GO:0031232,GO:0031236,GO:0042597,GO:0044425,GO:0044459,GO:0044464,GO:0048037,GO:0051536,GO:0051540,GO:0071944,GO:0098552,GO:0098567	1.12.2.1,1.12.99.6	ko:K06282,ko:K18008	ko00633,ko01120,map00633,map01120		R08034	RC00250	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_76,iUTI89_1310.UTI89_C1040	Bacteria	1MWAC@1224,1RNTJ@1236,3XMNB@561,COG1740@1,COG1740@2	NA|NA|NA	C	This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD2 is involved in hydrogen uptake
C1_00129	155864.EDL933_4218	1.8e-197	694.9	Escherichia	hybA	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0005975,GO:0006066,GO:0006071,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016052,GO:0019400,GO:0019405,GO:0019563,GO:0019588,GO:0019662,GO:0019751,GO:0031224,GO:0031226,GO:0042597,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0044425,GO:0044459,GO:0044464,GO:0046164,GO:0046174,GO:0055114,GO:0071704,GO:0071944,GO:1901575,GO:1901615,GO:1901616		ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200		R00519	RC02796	ko00000,ko00001				Bacteria	1MU1B@1224,1RPF5@1236,3XNNR@561,COG0437@1,COG0437@2	NA|NA|NA	C	Participates in the periplasmic electron-transferring activity of hydrogenase 2 during its catalytic turnover
C1_00130	316407.85675803	2.8e-221	774.2	Escherichia	hybB	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944										iAPECO1_1312.APECO1_3427,iE2348C_1286.E2348C_3282,iECABU_c1320.ECABU_c34010,iECOK1_1307.ECOK1_3414,iECS88_1305.ECS88_3377,iUMN146_1321.UM146_01380,iUTI89_1310.UTI89_C3417	Bacteria	1MWYI@1224,1RMUY@1236,3XP4N@561,COG5557@1,COG5557@2	NA|NA|NA	C	Ni Fe-hydrogenase 2 b-type cytochrome subunit
C1_00131	1440052.EAKF1_ch2954	0.0	1164.1	Escherichia	hybC	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0009897,GO:0009986,GO:0016020,GO:0016151,GO:0019897,GO:0019898,GO:0031232,GO:0031236,GO:0043167,GO:0043169,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0071944,GO:0098552,GO:0098567	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120		R08034	RC00250	ko00000,ko00001,ko01000			iSbBS512_1146.SbBS512_E2342,ic_1306.c3731	Bacteria	1MWFJ@1224,1RMC3@1236,3XNXZ@561,COG0374@1,COG0374@2	NA|NA|NA	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family
C1_00132	198214.SF3040	3.9e-84	317.4	Gammaproteobacteria	hybD	GO:0003674,GO:0003824,GO:0004175,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0070011,GO:0071704,GO:0140096,GO:1901564		ko:K03605					ko00000,ko01000,ko01002			iAF987.Gmet_3329	Bacteria	1RE1C@1224,1S4H2@1236,COG0680@1,COG0680@2	NA|NA|NA	C	Hydrogenase expression formation protein
C1_00133	199310.c3729	1.8e-89	335.1	Escherichia	hybE	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005515,GO:0006091,GO:0006807,GO:0008150,GO:0008152,GO:0008199,GO:0009055,GO:0009987,GO:0010467,GO:0016491,GO:0019538,GO:0022900,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046872,GO:0046914,GO:0051604,GO:0055114,GO:0070678,GO:0071704,GO:1901564		ko:K03618					ko00000				Bacteria	1N813@1224,1S4PE@1236,3XN10@561,COG1773@1,COG1773@2	NA|NA|NA	C	preprotein binding
C1_00134	1440052.EAKF1_ch2957	9.4e-61	239.2	Escherichia	hypA	GO:0003674,GO:0005488,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0010467,GO:0016151,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0046914,GO:0051604,GO:0071704,GO:1901564		ko:K04651					ko00000,ko03110				Bacteria	1MZJH@1224,1S5WG@1236,3XR02@561,COG0375@1,COG0375@2	NA|NA|NA	S	Probably plays a role in a hydrogenase nickel cofactor insertion step
C1_00135	155864.EDL933_4212	1.5e-39	168.3	Escherichia	hybG	GO:0003674,GO:0005488,GO:0005506,GO:0005515,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0010467,GO:0019538,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0046914,GO:0051604,GO:0071704,GO:1901564,GO:1902670		ko:K04653					ko00000				Bacteria	1RGXH@1224,1S96I@1236,3XQ31@561,COG0298@1,COG0298@2	NA|NA|NA	O	May have a specific role in the maturation of the large subunits of HYD1 and HYD2
C1_00136	155864.EDL933_4211	1.4e-169	602.1	Escherichia	yghU	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0015036,GO:0016491,GO:0016667,GO:0055114		ko:K11209					ko00000,ko01000				Bacteria	1MUN3@1224,1RMF7@1236,3XMFV@561,COG0625@1,COG0625@2	NA|NA|NA	O	the actual physiological substrates are not known. Also displays a modest GSH-dependent peroxidase activity toward several organic hydroperoxides, such as cumene hydroperoxide and linoleic acid 13(S)-hydroperoxide, but does not reduce H(2)O(2) or tert- butyl hydroperoxide at appreciable rates. Exhibits little or no GSH transferase activity with most typical electrophilic substrates, and has no detectable transferase activity toward 1- chloro-2,4-dinitrobenzene (CDNB) with glutathionylspermidine (GspSH) as the nucleophilic substrate
C1_00137	198214.SF3035	0.0	1293.1	Gammaproteobacteria	gsp	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008884,GO:0008885,GO:0016787,GO:0016810,GO:0016811,GO:0016874,GO:0016879,GO:0016880,GO:0044424,GO:0044444,GO:0044464	3.5.1.78,6.3.1.8	ko:K01460	ko00480,ko01100,map00480,map01100		R01917,R01918	RC00090,RC00096	ko00000,ko00001,ko01000			iECIAI39_1322.ECIAI39_3484	Bacteria	1MW6V@1224,1RQAP@1236,COG0754@1,COG0754@2	NA|NA|NA	E	Glutathionylspermidine synthase
C1_00138	469008.B21_02812	2.6e-272	944.1	Escherichia	pitA	GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661		ko:K03306,ko:K16322					ko00000,ko02000	2.A.20,2.A.20.1		iECABU_c1320.ECABU_c33930,iECO111_1330.ECO111_4301	Bacteria	1MVXK@1224,1RP0Q@1236,3XM91@561,COG0306@1,COG0306@2	NA|NA|NA	P	phosphate transporter
C1_00139	316407.85675794	2e-126	458.4	Escherichia	tmk	GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.45,2.7.4.9	ko:K00560,ko:K00943	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02094,R02098,R02101	RC00002,RC00219,RC00332	ko00000,ko00001,ko00002,ko01000			iECABU_c1320.ECABU_c13120,ic_1306.c1370	Bacteria	1N7QZ@1224,1RSDM@1236,3XNH2@561,COG0125@1,COG0125@2	NA|NA|NA	F	ATP binding
C1_00140	316407.85675793	5.7e-129	466.8	Escherichia	tmk	GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.45,2.7.4.9	ko:K00560,ko:K00943	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02094,R02098,R02101	RC00002,RC00219,RC00332	ko00000,ko00001,ko00002,ko01000			iECABU_c1320.ECABU_c13120,ic_1306.c1370	Bacteria	1R4NC@1224,1RPR5@1236,3XM9D@561,COG0125@1,COG0125@2	NA|NA|NA	F	ATP binding
C1_00141	362663.ECP_3069	3.6e-137	494.2	Escherichia	tmk		2.1.1.45,2.7.4.9	ko:K00560,ko:K00943	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02094,R02098,R02101	RC00002,RC00219,RC00332	ko00000,ko00001,ko00002,ko01000			iECABU_c1320.ECABU_c13120,ic_1306.c1370	Bacteria	1R6BR@1224,1RSID@1236,3XMQU@561,COG0125@1,COG0125@2	NA|NA|NA	F	ATP binding
C1_00142	469008.B21_02808	2.1e-244	851.3	Escherichia	yghQ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1RDQG@1224,1RMK6@1236,3XMZ2@561,COG2244@1,COG2244@2	NA|NA|NA	S	Polysaccharide biosynthesis protein
C1_00143	199310.c3719	1.2e-149	535.8	Escherichia	JD73_00845												Bacteria	1MW3E@1224,1RPJ1@1236,28HJM@1,2Z7UR@2,3XMHB@561	NA|NA|NA		
C1_00144	198214.SF3028	4.9e-99	367.1	Gammaproteobacteria	ytfJ			ko:K07109					ko00000				Bacteria	1RB2K@1224,1S2I1@1236,COG3054@1,COG3054@2	NA|NA|NA	S	Bacterial protein of unknown function (YtfJ_HI0045)
C1_00145	362663.ECP_3065	2.3e-185	654.8	Escherichia	JD73_00835			ko:K07091,ko:K11720	ko02010,map02010	M00320			ko00000,ko00001,ko00002,ko02000	1.B.42.1		iECED1_1282.ECED1_5114	Bacteria	1MUF2@1224,1RMN5@1236,3XMP1@561,COG0795@1,COG0795@2	NA|NA|NA	S	Predicted permease YjgP/YjgQ family
C1_00146	199310.c3716	3.4e-189	667.5	Escherichia	lptG			ko:K11720	ko02010,map02010	M00320			ko00000,ko00001,ko00002,ko02000	1.B.42.1		iSSON_1240.SSON_4447	Bacteria	1MVW3@1224,1RM8H@1236,3XNNU@561,COG0795@1,COG0795@2	NA|NA|NA	S	Predicted permease YjgP/YjgQ family
C1_00147	199310.c3715	2.3e-215	754.6	Escherichia	bioF		2.3.1.29,2.3.1.47,2.3.1.50	ko:K00639,ko:K00652,ko:K00654	ko00260,ko00600,ko00780,ko01100,ko04071,ko04138,map00260,map00600,map00780,map01100,map04071,map04138	M00094,M00099,M00123,M00573,M00577	R00371,R01281,R03210,R10124	RC00004,RC00039,RC00394,RC02725,RC02849	ko00000,ko00001,ko00002,ko01000,ko01007			iECW_1372.ECW_m3896,iEKO11_1354.EKO11_0103,iWFL_1372.ECW_m3896	Bacteria	1MVVH@1224,1RNS6@1236,3XMFT@561,COG0156@1,COG0156@2	NA|NA|NA	E	Aminotransferase class-V
C1_00148	198214.SF3023	9e-37	159.1	Gammaproteobacteria	AKN40_0794			ko:K02078,ko:K14661					ko00000,ko00001,ko01000				Bacteria	1NHQD@1224,1SA25@1236,COG0236@1,COG0236@2	NA|NA|NA	IQ	acyl carrier protein
C1_00149	362663.ECP_3061	1.5e-169	602.1	Escherichia	JD73_00815		5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000				Bacteria	1QV3X@1224,1RWPZ@1236,3XMKB@561,COG0451@1,COG0451@2	NA|NA|NA	GM	NmrA-like family
C1_00150	481805.EcolC_0718	0.0	1142.9	Escherichia	JD73_00810			ko:K00666					ko00000,ko01000,ko01004				Bacteria	1MU6G@1224,1T1II@1236,3XP2C@561,COG0318@1,COG0318@2	NA|NA|NA	IQ	AMP-binding enzyme
C1_00151	199310.c3711	8.2e-226	789.3	Escherichia	yghO	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141											Bacteria	1PMA3@1224,1RS1U@1236,3XPHS@561,COG0454@1,COG0456@2	NA|NA|NA	K	acetyltransferase
C1_00152	199310.c3710	1.8e-136	491.9	Escherichia	glcC	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141		ko:K05799,ko:K11474					ko00000,ko03000				Bacteria	1R8M2@1224,1RZIJ@1236,3XPCH@561,COG2186@1,COG2186@2	NA|NA|NA	K	Activator for the glycolate oxidation locus
C1_00153	199310.c3709	1.1e-289	1001.9	Escherichia	glcD	GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0033554,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616	1.1.2.4,1.1.3.15	ko:K00102,ko:K00104	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130		R00197,R00475	RC00042,RC00044	ko00000,ko00001,ko01000			iJN746.PP_3745,iLF82_1304.LF82_0831,iNRG857_1313.NRG857_14750	Bacteria	1MU6Y@1224,1RQX2@1236,3XN6A@561,COG0277@1,COG0277@2	NA|NA|NA	C	Glycolate oxidase subunit
C1_00154	481805.EcolC_0722	5.3e-203	713.4	Escherichia	glcE	GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616		ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130		R00475	RC00042	ko00000,ko00001			iETEC_1333.ETEC_3246	Bacteria	1MVYV@1224,1RN4G@1236,3XMBG@561,COG0277@1,COG0277@2	NA|NA|NA	C	glycolate dehydrogenase activity
C1_00155	362663.ECP_3055	6.7e-234	816.2	Escherichia	glcF	GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616		ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130		R00475	RC00042	ko00000,ko00001			iAPECO1_1312.glcF,iECABU_c1320.ECABU_c33760,iECIAI1_1343.ECIAI1_3119,iECIAI39_1322.ECIAI39_3465,iECNA114_1301.ECNA114_3053,iECP_1309.ECP_3055,iJN678.glcF,iUTI89_1310.glcF,ic_1306.glcF	Bacteria	1MWTK@1224,1RPAB@1236,3XPGJ@561,COG0247@1,COG0247@2	NA|NA|NA	C	glycolate dehydrogenase activity
C1_00156	199310.c3706	1.1e-55	222.6	Escherichia	glcG			ko:K11477					ko00000				Bacteria	1RGUD@1224,1S7TR@1236,3XQ5K@561,COG3193@1,COG3193@2	NA|NA|NA	S	Haem-degrading
C1_00157	316407.85675783	0.0	1441.4	Escherichia	glcB	GO:0000287,GO:0003674,GO:0003824,GO:0004474,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009436,GO:0009987,GO:0016054,GO:0016740,GO:0016746,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0046395,GO:0046487,GO:0046872,GO:0046912,GO:0071704,GO:0072329,GO:1901575	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000			iECSF_1327.ECSF_2799,iECW_1372.ECW_m3242,iEKO11_1354.EKO11_0745,iWFL_1372.ECW_m3242	Bacteria	1MVEV@1224,1RPVI@1236,3XP66@561,COG2225@1,COG2225@2	NA|NA|NA	C	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C1_00158	316407.85675782	2.4e-306	1057.4	Escherichia	glcA	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006950,GO:0006974,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015672,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0033554,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600		ko:K00427,ko:K02550,ko:K03303					ko00000,ko02000	2.A.14,2.A.14.1.1,2.A.14.1.2		e_coli_core.b3603,iAF1260.b3603,iECDH1ME8569_1439.ECDH1ME8569_3488,iECW_1372.ECW_m3882,iEcDH1_1363.EcDH1_0102,iEcolC_1368.EcolC_0105,iG2583_1286.G2583_3693,iIT341.HP0140,iIT341.HP0141,iJO1366.b3603,iJR904.b3603,iSF_1195.SF3014,iWFL_1372.ECW_m3882	Bacteria	1MV13@1224,1RPNW@1236,3XPDD@561,COG1620@1,COG1620@2	NA|NA|NA	P	Glycolate permease glcA
C1_00159	316407.85675781	0.0	2898.6	Escherichia	acfD			ko:K02004,ko:K10939,ko:K12257,ko:K14393	ko02024,ko03060,ko03070,ko05111,map02024,map03060,map03070,map05111	M00258,M00335			ko00000,ko00001,ko00002,ko02000,ko02044	2.A.21.7,2.A.6.4,3.A.1			Bacteria	1N5U6@1224,1RYM4@1236,3XN17@561,COG3064@1,COG3064@2	NA|NA|NA	M	N-terminal domain of M60-like peptidases
C1_00160	316407.85675780	2.8e-148	531.2	Escherichia	pppA	GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016020,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564	3.4.23.43	ko:K02464,ko:K02654	ko03070,map03070	M00331			ko00000,ko00001,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15,3.A.15.2			Bacteria	1MUZF@1224,1RN90@1236,3XMEH@561,COG1989@1,COG1989@2	NA|NA|NA	NOU	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C1_00161	316407.85675779	4.7e-67	260.4	Escherichia	yghG	GO:0005575,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0033554,GO:0044462,GO:0044464,GO:0050896,GO:0051716,GO:0071944											Bacteria	1P4P0@1224,1SWA2@1236,2B0AA@1,2ZG1M@2,3XPTJ@561	NA|NA|NA	M	cellular response to DNA damage stimulus
C1_00162	469008.B21_02789	1.1e-139	502.7	Escherichia	gspC	GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705		ko:K02452	ko03070,ko05111,map03070,map05111	M00331			ko00000,ko00001,ko00002,ko02044	3.A.15			Bacteria	1RD3I@1224,1RQKA@1236,3XND8@561,COG3031@1,COG3031@2	NA|NA|NA	U	Type II secretion system protein C
C1_00163	362663.ECP_3046	0.0	1307.4	Escherichia	gspD			ko:K02453,ko:K03219	ko03070,ko05111,map03070,map05111	M00331,M00332,M00542			ko00000,ko00001,ko00002,ko02044	3.A.15,3.A.6.1,3.A.6.3			Bacteria	1MUUA@1224,1RPJS@1236,3XNXY@561,COG1450@1,COG1450@2	NA|NA|NA	NU	General secretion pathway protein
C1_00164	754331.AEME01000001_gene2528	2.5e-275	954.1	Escherichia	gspE			ko:K02454	ko03070,ko05111,map03070,map05111	M00331			ko00000,ko00001,ko00002,ko02044	3.A.15			Bacteria	1MU7V@1224,1RMBS@1236,3XP2X@561,COG2804@1,COG2804@2	NA|NA|NA	NU	Type II/IV secretion system protein
C1_00165	469008.B21_02786	2.3e-210	738.0	Escherichia	gspF	GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0016020,GO:0032940,GO:0033036,GO:0042886,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098776		ko:K02455,ko:K02505,ko:K02653	ko03070,ko05111,map03070,map05111	M00331			ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2			Bacteria	1MV4U@1224,1RQ86@1236,3XN4J@561,COG1459@1,COG1459@2	NA|NA|NA	U	General secretion pathway
C1_00166	362663.ECP_3043	1e-78	299.3	Escherichia	gspG	GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705		ko:K02246,ko:K02456,ko:K02457,ko:K02458,ko:K02679	ko03070,ko05111,map03070,map05111	M00331,M00429			ko00000,ko00001,ko00002,ko02044	3.A.15			Bacteria	1RDX2@1224,1S3VS@1236,3XPD0@561,COG2165@1,COG2165@2	NA|NA|NA	U	General secretion pathway protein
C1_00167	362663.ECP_3042	1.6e-97	362.1	Escherichia	gspH	GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705		ko:K02456,ko:K02457,ko:K02458,ko:K02650,ko:K02679	ko02020,ko03070,ko05111,map02020,map03070,map05111	M00331			ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2			Bacteria	1NP8Q@1224,1SGBJ@1236,3XP4V@561,COG2165@1,COG2165@2	NA|NA|NA	NU	Type II transport protein GspH
C1_00168	469008.B21_02783	4.8e-58	230.3	Escherichia	gspI	GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705		ko:K02456,ko:K02457,ko:K02458,ko:K02679	ko03070,ko05111,map03070,map05111	M00331			ko00000,ko00001,ko00002,ko02044	3.A.15			Bacteria	1N737@1224,1SC8X@1236,3XPQB@561,COG2165@1,COG2165@2	NA|NA|NA	NU	Type II secretion system (T2SS), protein I
C1_00169	362663.ECP_3040	4.6e-103	380.6	Escherichia	gspJ	GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0098776		ko:K02459,ko:K02680	ko03070,ko05111,map03070,map05111	M00331			ko00000,ko00001,ko00002,ko02044	3.A.15			Bacteria	1RJAE@1224,1S5ZZ@1236,3XPFX@561,COG4795@1,COG4795@2	NA|NA|NA	U	Type II secretion system (T2SS), protein J
C1_00170	469008.B21_02781	6.9e-173	613.2	Escherichia	gspK	GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705		ko:K02460	ko03070,ko05111,map03070,map05111	M00331			ko00000,ko00001,ko00002,ko02044	3.A.15			Bacteria	1RC9P@1224,1T072@1236,3XPI1@561,COG3156@1,COG3156@2	NA|NA|NA	U	Type II secretion system
C1_00171	362663.ECP_3038	2.1e-208	731.5	Escherichia	gspL	GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705		ko:K02461	ko03070,ko05111,map03070,map05111	M00331			ko00000,ko00001,ko00002,ko02044	3.A.15			Bacteria	1NVVW@1224,1S01F@1236,3XNEN@561,COG3297@1,COG3297@2	NA|NA|NA	U	involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
C1_00172	316407.85675777	5.6e-92	343.6	Escherichia	gspM	GO:0008150,GO:0009405,GO:0044419,GO:0051704		ko:K02462	ko03070,ko05111,map03070,map05111	M00331			ko00000,ko00001,ko00002,ko02044	3.A.15			Bacteria	1N8VZ@1224,1S8X3@1236,3XNEI@561,COG3149@1,COG3149@2	NA|NA|NA	U	involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
C1_00174	316407.85675776	3.5e-118	431.0	Escherichia	yqgA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K07150					ko00000				Bacteria	1MX1D@1224,1RYSH@1236,3XNGF@561,COG1811@1,COG1811@2	NA|NA|NA	S	Protein of unknown function (DUF554)
C1_00175	469008.B21_02758	0.0	1443.3	Escherichia	speC	GO:0003674,GO:0003824,GO:0004586,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0019842,GO:0030170,GO:0034641,GO:0036094,GO:0042401,GO:0043167,GO:0043168,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:0097164,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.1.1.17,4.1.1.18,4.1.1.19	ko:K01581,ko:K01582,ko:K01584,ko:K01585	ko00310,ko00330,ko00480,ko00960,ko01100,ko01110,ko01130,map00310,map00330,map00480,map00960,map01100,map01110,map01130	M00133,M00134	R00462,R00566,R00670	RC00299	ko00000,ko00001,ko00002,ko01000			iEC042_1314.EC042_4483,iEcHS_1320.EcHS_A3126,iSbBS512_1146.SbBS512_E0179	Bacteria	1MWK4@1224,1RMVF@1236,3XNIH@561,COG1982@1,COG1982@2	NA|NA|NA	E	putrescine biosynthetic process from ornithine
C1_00176	155864.EDL933_4178	1.3e-232	812.0	Escherichia	nupG	GO:0003674,GO:0005215,GO:0005337,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0015212,GO:0015213,GO:0015214,GO:0015858,GO:0015860,GO:0015861,GO:0015862,GO:0015864,GO:0015893,GO:0015931,GO:0015932,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0032238,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072530,GO:0072531,GO:1901264,GO:1901505,GO:1901642		ko:K03289,ko:K03301,ko:K08218,ko:K11537	ko01501,map01501	M00628			ko00000,ko00001,ko00002,ko02000	2.A.1.10.1,2.A.1.10.2,2.A.1.25,2.A.12		iECW_1372.ECW_m2299,iEcSMS35_1347.EcSMS35_3108,iWFL_1372.ECW_m2299	Bacteria	1MWI9@1224,1RMU5@1236,3XNB0@561,COG2211@1,COG2211@2	NA|NA|NA	G	Broad-specificity transporter of purine and pyrimidine nucleosides. Driven by a proton motive force
C1_00177	199310.c3551	2.9e-204	717.6	Escherichia	mltC	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008932,GO:0008933,GO:0009056,GO:0009057,GO:0009253,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0030203,GO:0030288,GO:0030313,GO:0031224,GO:0031225,GO:0031975,GO:0033554,GO:0034599,GO:0042221,GO:0042597,GO:0043170,GO:0044425,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0061783,GO:0070887,GO:0071236,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575		ko:K08306,ko:K08308,ko:K08309					ko00000,ko01000,ko01011		GH23	iG2583_1286.G2583_3622,iUMNK88_1353.UMNK88_3661	Bacteria	1MW2T@1224,1RM9N@1236,3XN2V@561,COG0741@1,COG0741@2	NA|NA|NA	M	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
C1_00178	1440052.EAKF1_ch3029c	6.9e-46	189.5	Escherichia	yggX	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0033554,GO:0034599,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0070887											Bacteria	1MZ2V@1224,1S964@1236,3XPVI@561,COG2924@1,COG2924@2	NA|NA|NA	CO	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C1_00179	316407.85675771	2.1e-207	728.0	Escherichia	mutY	GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360		ko:K03575	ko03410,map03410				ko00000,ko00001,ko01000,ko03400				Bacteria	1MUD4@1224,1RMBT@1236,3XNBT@561,COG1194@1,COG1194@2	NA|NA|NA	L	A G-specific adenine glycosylase
C1_00180	198214.SF2957	2.4e-138	498.0	Gammaproteobacteria	trmB	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0040007,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.297,2.1.1.33,2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02493,ko:K02527,ko:K03439	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763,R10806	RC00003,RC00009,RC00077,RC00247,RC03279	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005,ko03012,ko03016		GT30		Bacteria	1MUWJ@1224,1RMFG@1236,COG0220@1,COG0220@2	NA|NA|NA	J	catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
C1_00181	316407.85675769	1.8e-56	224.9	Escherichia	yggL	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K09923					ko00000				Bacteria	1RH3U@1224,1S6UT@1236,3XPPI@561,COG3171@1,COG3171@2	NA|NA|NA	S	Protein with unknown function (DUF469)
C1_00182	155864.EDL933_4170	1.4e-125	455.7	Escherichia	yggN												Bacteria	1MXU1@1224,1RPHU@1236,28H6P@1,2Z7J1@2,3XMGC@561	NA|NA|NA	S	Protein of unknown function (DUF2884)
C1_00183	481805.EcolC_0757	4.6e-191	673.7	Escherichia	ansB	GO:0003674,GO:0003824,GO:0004067,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006528,GO:0006530,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009066,GO:0009068,GO:0009987,GO:0016043,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0022607,GO:0030288,GO:0030313,GO:0031975,GO:0032787,GO:0034641,GO:0042597,GO:0042802,GO:0043436,GO:0043603,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:0072329,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	3.5.1.1,3.5.1.38	ko:K01424,ko:K05597	ko00220,ko00250,ko00460,ko00471,ko01100,ko01110,ko02020,map00220,map00250,map00460,map00471,map01100,map01110,map02020		R00256,R00485,R01579	RC00010,RC02798	ko00000,ko00001,ko01000				Bacteria	1MWIR@1224,1RNPN@1236,3XP5U@561,COG0252@1,COG0252@2	NA|NA|NA	EJ	Belongs to the asparaginase 1 family
C1_00184	481805.EcolC_0758	3.9e-187	660.6	Escherichia	yggM												Bacteria	1R82P@1224,1RRVP@1236,28JQ2@1,2Z9G0@2,3XP2M@561	NA|NA|NA	S	Protein of unknown function (DUF1202)
C1_00185	198214.SF2952	6.1e-225	786.6	Gammaproteobacteria													Bacteria	1MU0F@1224,1RNAM@1236,COG1593@1,COG1593@2	NA|NA|NA	G	TRAP-type C4-dicarboxylate transport system, large permease component
C1_00186	198214.SF2949	1.6e-77	295.4	Gammaproteobacteria				ko:K11689	ko02020,map02020				ko00000,ko00001,ko02000	2.A.56.1			Bacteria	1RJ8K@1224,1SA02@1236,COG3090@1,COG3090@2	NA|NA|NA	G	TRAP-type C4-dicarboxylate transport system small permease component
C1_00187	1218086.BBNB01000011_gene599	4.4e-159	567.4	Citrobacter													Bacteria	1MVHC@1224,1RPNJ@1236,3WXJ6@544,COG1638@1,COG1638@2	NA|NA|NA	G	Bacterial extracellular solute-binding protein, family 7
C1_00188	198214.SF2946	5.3e-225	786.6	Gammaproteobacteria	hemN	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576											Bacteria	1MU76@1224,1RN6I@1236,COG0635@1,COG0635@2	NA|NA|NA	H	Involved in the biosynthesis of porphyrin-containing compound
C1_00189	198214.SF2945	4.9e-105	387.1	Gammaproteobacteria	rdgB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035870,GO:0036220,GO:0036222,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0046983,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66,5.1.1.3	ko:K01776,ko:K02428	ko00230,ko00471,ko01100,map00230,map00471,map01100		R00260,R00426,R00720,R01855,R02100,R02720,R03531	RC00002,RC00302	ko00000,ko00001,ko01000,ko01011			iEC55989_1330.EC55989_3247,iECO111_1330.ECO111_3702,iECSE_1348.ECSE_3222,iECW_1372.ECW_m3212,iEKO11_1354.EKO11_0774,iEcE24377_1341.EcE24377A_3298,iWFL_1372.ECW_m3212	Bacteria	1MUK5@1224,1S27C@1236,COG0127@1,COG0127@2	NA|NA|NA	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C1_00190	198214.SF2944	7.3e-46	189.5	Gammaproteobacteria	yggU			ko:K09131					ko00000				Bacteria	1MZ4E@1224,1S9AB@1236,COG1872@1,COG1872@2	NA|NA|NA	S	Belongs to the UPF0235 family
C1_00191	155864.EDL933_4164	2.6e-92	344.7	Escherichia	yggT	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02221					ko00000,ko02044				Bacteria	1RCZV@1224,1S6DW@1236,3XNT9@561,COG0762@1,COG0762@2	NA|NA|NA	S	YGGT family
C1_00192	155864.EDL933_4163	1.6e-126	458.8	Escherichia	yggS	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363		ko:K06997					ko00000				Bacteria	1MWN7@1224,1RNPM@1236,3XM2S@561,COG0325@1,COG0325@2	NA|NA|NA	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C1_00193	481805.EcolC_0764	1.2e-177	629.0	Escherichia	yggR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K02669					ko00000,ko02035,ko02044	3.A.15.2			Bacteria	1MU3J@1224,1RN8G@1236,3XN5A@561,COG2805@1,COG2805@2	NA|NA|NA	NU	ATP binding
C1_00194	637910.ROD_00481	2.1e-161	575.1	Gammaproteobacteria	piv			ko:K07486					ko00000				Bacteria	1MXKJ@1224,1RSCP@1236,COG3547@1,COG3547@2	NA|NA|NA	L	Transposase
C1_00195	198214.SF2940	1.7e-72	278.5	Gammaproteobacteria	yqgF	GO:0000966,GO:0000967,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0140097,GO:1901360		ko:K07447					ko00000,ko01000				Bacteria	1RDHZ@1224,1S96Q@1236,COG0816@1,COG0816@2	NA|NA|NA	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C1_00196	198214.SF2939	2.3e-116	424.9	Gammaproteobacteria	yqgE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K07735					ko00000,ko03000				Bacteria	1RCXM@1224,1S3YV@1236,COG1678@1,COG1678@2	NA|NA|NA	K	Belongs to the UPF0301 (AlgH) family
C1_00197	316407.85675757	3.3e-180	637.5	Escherichia	gshB	GO:0000287,GO:0003674,GO:0003824,GO:0004363,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0019184,GO:0034641,GO:0042398,GO:0042601,GO:0042763,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:1901564,GO:1901566,GO:1901576	6.3.2.2,6.3.2.3	ko:K01919,ko:K01920,ko:K05844	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00497,R00894,R10993,R10994	RC00064,RC00090,RC00096,RC00141	ko00000,ko00001,ko00002,ko01000,ko03009			iECED1_1282.ECED1_3410,iECP_1309.ECP_2941	Bacteria	1MVUA@1224,1RMU0@1236,3XNGA@561,COG0189@1,COG0189@2	NA|NA|NA	F	glutathione synthase activity
C1_00198	155864.EDL933_4157	1.6e-134	485.3	Escherichia	rsmE	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070042,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.193	ko:K09761					ko00000,ko01000,ko03009				Bacteria	1MXCU@1224,1RPBN@1236,3XN95@561,COG1385@1,COG1385@2	NA|NA|NA	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
C1_00199	316407.85675755	6.2e-131	473.4	Escherichia	endA	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005576,GO:0005623,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0019439,GO:0034641,GO:0034655,GO:0042597,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575	3.1.21.1	ko:K01150					ko00000,ko01000				Bacteria	1MXQM@1224,1RPX9@1236,3XN9S@561,COG2356@1,COG2356@2	NA|NA|NA	L	deoxyribonuclease I activity
C1_00200	199310.c3530	1.2e-82	312.4	Escherichia	sprT			ko:K02742					ko00000				Bacteria	1RJW4@1224,1S70F@1236,3XP6D@561,COG3091@1,COG3091@2	NA|NA|NA	S	Belongs to the SprT family
C1_00201	199310.c3529	7.6e-258	896.0	Escherichia	galP	GO:0003674,GO:0005215,GO:0005351,GO:0005354,GO:0005402,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0008643,GO:0008645,GO:0009679,GO:0015075,GO:0015077,GO:0015078,GO:0015144,GO:0015145,GO:0015149,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015517,GO:0015672,GO:0015749,GO:0015757,GO:0016020,GO:0022804,GO:0022857,GO:0022890,GO:0034219,GO:0034220,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600		ko:K02100,ko:K08137					ko00000,ko02000	2.A.1.1.1,2.A.1.1.2		iG2583_1286.G2583_3602	Bacteria	1MVKJ@1224,1RMHJ@1236,3XN94@561,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
C1_00202	155864.EDL933_4152	3.1e-212	744.2	Escherichia	metK	GO:0000096,GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004478,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006556,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009069,GO:0009108,GO:0009116,GO:0009119,GO:0009987,GO:0016740,GO:0016765,GO:0017076,GO:0017144,GO:0019752,GO:0030554,GO:0030955,GO:0031420,GO:0032553,GO:0032555,GO:0032559,GO:0033353,GO:0034641,GO:0035639,GO:0036094,GO:0042278,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0046872,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901576,GO:1901605,GO:1901657	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000			iJN746.PP_4967,iYL1228.KPN_03375	Bacteria	1MUFQ@1224,1RNV6@1236,3XP3M@561,COG0192@1,COG0192@2	NA|NA|NA	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C1_00203	469008.B21_02734	5.1e-40	169.9	Gammaproteobacteria	yqgD												Bacteria	1PBF5@1224,1SU2F@1236,2C4JF@1,2ZP5F@2	NA|NA|NA	S	Protein of unknown function (DUF2684)
C1_00204	199310.c3524	0.0	1323.1	Escherichia	speA	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008792,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009065,GO:0009308,GO:0009309,GO:0009445,GO:0009446,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0034641,GO:0042401,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044271,GO:0044281,GO:0044282,GO:0046395,GO:0071704,GO:0097164,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_3590,iE2348C_1286.E2348C_3191,iEC55989_1330.EC55989_3231,iECABU_c1320.ECABU_c32250,iECED1_1282.ECED1_3401,iECIAI1_1343.ECIAI1_3071,iECIAI39_1322.ECIAI39_3358,iECO103_1326.ECO103_3518,iECO26_1355.ECO26_4037,iECOK1_1307.ECOK1_3327,iECP_1309.ECP_2933,iECS88_1305.ECS88_3221,iECSE_1348.ECSE_3207,iECSF_1327.ECSF_2737,iECSP_1301.ECSP_3909,iECUMN_1333.ECUMN_3290,iECW_1372.ECW_m3198,iECs_1301.ECs3814,iEKO11_1354.EKO11_0788,iEcE24377_1341.EcE24377A_3281,iEcHS_1320.EcHS_A3096,iEcolC_1368.EcolC_0773,iG2583_1286.G2583_3597,iIT341.HP0422,iLF82_1304.LF82_2157,iNRG857_1313.NRG857_14440,iPC815.YPO0929,iSBO_1134.SBO_3051,iSDY_1059.SDY_3134,iSSON_1240.SSON_3092,iSbBS512_1146.SbBS512_E3371,iWFL_1372.ECW_m3198,iZ_1308.Z4283	Bacteria	1MU80@1224,1RP2J@1236,3XMWR@561,COG1166@1,COG1166@2	NA|NA|NA	H	Catalyzes the biosynthesis of agmatine from arginine
C1_00205	199310.c3523	2.1e-134	485.0	Escherichia													Bacteria	1RBYB@1224,1S4GK@1236,28T75@1,2ZFFV@2,3XQJX@561	NA|NA|NA		
C1_00206	1440052.EAKF1_ch3055	2.8e-176	624.4	Escherichia	speB	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008783,GO:0009058,GO:0009308,GO:0009309,GO:0009445,GO:0009446,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0030145,GO:0034641,GO:0042401,GO:0043167,GO:0043169,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576	3.5.3.11	ko:K01480,ko:K12541	ko00330,ko01100,ko02010,map00330,map01100,map02010	M00133,M00330	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000,ko02000,ko02044	3.A.1.109.3,3.A.1.109.4		iB21_1397.B21_02730,iECB_1328.ECB_02767,iECD_1391.ECD_02767,iSbBS512_1146.SbBS512_E3370	Bacteria	1MVFH@1224,1RMH5@1236,3XNY2@561,COG0010@1,COG0010@2	NA|NA|NA	E	Catalyzes the formation of putrescine from agmatine
C1_00207	1114922.CIFAM_12_02440	0.0	1618.6	Citrobacter				ko:K03974,ko:K17473					ko00000,ko03000				Bacteria	1R3VP@1224,1RQKE@1236,3WXZT@544,COG1221@1,COG1221@2,COG3933@1,COG3933@2	NA|NA|NA	K	PRD domain
C1_00208	35703.DQ02_00265	1.3e-62	245.7	Citrobacter			2.7.1.203	ko:K17464	ko00030,ko01120,ko02060,map00030,map01120,map02060	M00610	R10407	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.6.1.17			Bacteria	1RC64@1224,1S3K7@1236,3WYCN@544,COG2893@1,COG2893@2	NA|NA|NA	G	PTS system fructose IIA component
C1_00209	1114922.CIFAM_12_02420	1.8e-81	308.5	Citrobacter			2.7.1.203	ko:K17465	ko00030,ko01120,ko02060,map00030,map01120,map02060	M00610	R10407	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.6.1.17			Bacteria	1P9P7@1224,1RYVC@1236,3WXA7@544,COG3444@1,COG3444@2	NA|NA|NA	G	PTS system sorbose subfamily IIB component
C1_00210	1218086.BBNB01000004_gene3164	2.1e-129	468.4	Citrobacter				ko:K17466	ko00030,ko01120,ko02060,map00030,map01120,map02060	M00610	R10407	RC00017,RC03206	ko00000,ko00001,ko00002,ko02000	4.A.6.1.17			Bacteria	1PGQK@1224,1RS3P@1236,3WY1X@544,COG3715@1,COG3715@2	NA|NA|NA	G	PTS system sorbose-specific iic component
C1_00211	1197719.A464_3840	5.3e-145	520.4	Salmonella				ko:K02796,ko:K17467,ko:K19509	ko00030,ko00051,ko00520,ko01100,ko01120,ko02060,map00030,map00051,map00520,map01100,map01120,map02060	M00276,M00610,M00764	R02630,R10407	RC00017,RC03206	ko00000,ko00001,ko00002,ko02000	4.A.6.1,4.A.6.1.17,4.A.6.1.19			Bacteria	1R50V@1224,1RQVW@1236,3ZJVG@590,COG3716@1,COG3716@2	NA|NA|NA	G	PTS system mannose/fructose/sorbose family IID component
C1_00212	500640.CIT292_10495	2.1e-186	658.3	Citrobacter	selA		2.9.1.1,4.3.1.29	ko:K01042,ko:K17468	ko00030,ko00450,ko00970,ko01120,map00030,map00450,map00970,map01120		R08219,R10408	RC00544,RC01246	ko00000,ko00001,ko01000				Bacteria	1MWCB@1224,1RZF1@1236,3WXKG@544,COG1921@1,COG1921@2	NA|NA|NA	E	L-seryl-tRNA selenium transferase
C1_00213	500640.CIT292_10494	3.6e-121	441.0	Citrobacter			4.1.2.14	ko:K17463	ko00030,ko01100,ko01120,map00030,map01100,map01120	M00061,M00631	R05605	RC00307,RC00435	ko00000,ko00001,ko00002,ko01000				Bacteria	1R59N@1224,1RYTS@1236,2DBAP@1,2Z844@2,3WXZY@544	NA|NA|NA	S	Pfam:DUF1341
C1_00214	155864.EDL933_4145	7.8e-132	476.5	Escherichia	yggG	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0006950,GO:0006970,GO:0006971,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009266,GO:0009279,GO:0009314,GO:0009408,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0033554,GO:0034605,GO:0034644,GO:0043170,GO:0044238,GO:0044462,GO:0044464,GO:0050896,GO:0051716,GO:0070011,GO:0071214,GO:0071470,GO:0071476,GO:0071478,GO:0071482,GO:0071704,GO:0071944,GO:0104004,GO:0140096,GO:1901564		ko:K07387					ko00000,ko01000,ko01002				Bacteria	1NK9F@1224,1RQSJ@1236,3XM4R@561,COG0501@1,COG0501@2	NA|NA|NA	O	Metalloprotease that cleaves substrates preferentially between Phe-Phe residues. Plays a role in response to some stress conditions. Seems to regulate the expression of speB
C1_00215	316407.85675745	0.0	1333.2	Escherichia	tkt	GO:0000302,GO:0003674,GO:0003824,GO:0004802,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006098,GO:0006139,GO:0006355,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009635,GO:0009636,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010033,GO:0010035,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016740,GO:0016744,GO:0019219,GO:0019222,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0019842,GO:0030145,GO:0030976,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0034641,GO:0035690,GO:0036094,GO:0036245,GO:0042221,GO:0042493,GO:0042542,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0046496,GO:0046677,GO:0046872,GO:0046914,GO:0048037,GO:0048518,GO:0048522,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051156,GO:0051171,GO:0051173,GO:0051186,GO:0051252,GO:0051254,GO:0051716,GO:0055086,GO:0060255,GO:0065007,GO:0070301,GO:0070887,GO:0071236,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0072524,GO:0072747,GO:0072756,GO:0080090,GO:0097159,GO:0097237,GO:1901135,GO:1901322,GO:1901360,GO:1901363,GO:1901562,GO:1901564,GO:1901654,GO:1901655,GO:1901681,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000			iECABU_c1320.ECABU_c27750,iLF82_1304.LF82_2271,iNRG857_1313.NRG857_12300,iSDY_1059.SDY_3141,iYL1228.KPN_01127,ic_1306.c2990	Bacteria	1MUEY@1224,1RMWP@1236,3XMMK@561,COG0021@1,COG0021@2	NA|NA|NA	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C1_00216	155864.EDL933_4142	1.2e-76	292.4	Escherichia	cmtB	GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0051179,GO:0051234,GO:0071702	2.7.1.194,2.7.1.197,2.7.1.200,2.7.1.202,2.7.3.9	ko:K02768,ko:K02769,ko:K02770,ko:K02773,ko:K02798,ko:K02806,ko:K02821,ko:K08483,ko:K11189,ko:K11201,ko:K18531	ko00051,ko00052,ko00053,ko01100,ko01120,ko02060,map00051,map00052,map00053,map01100,map01120,map02060	M00273,M00274,M00279,M00283,M00306,M00550	R02704,R03232,R05570,R07671	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1,4.A.2.1.12,4.A.2.1.2,4.A.2.1.24,4.A.2.1.5,4.A.5.1,4.A.7.1,8.A.7		iECABU_c1320.ECABU_c47530,iECIAI39_1322.ECIAI39_0923,iECUMN_1333.ECUMN_4728,iEcSMS35_1347.EcSMS35_4666,ic_1306.c5284	Bacteria	1RKSR@1224,1S6J2@1236,3XPPH@561,COG1762@1,COG1762@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport
C1_00217	155864.EDL933_4141	2.6e-258	897.5	Escherichia	cmtA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563	2.7.1.197	ko:K02799,ko:K02800	ko00051,ko02060,map00051,map02060	M00274	R02704	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1.12,4.A.2.1.2,4.A.2.1.24,4.A.2.1.5			Bacteria	1Q9RR@1224,1RN2G@1236,3XMGV@561,COG2213@1,COG2213@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport
C1_00218	316407.85675742	4.4e-244	850.1	Escherichia	yggP			ko:K19956	ko00051,map00051		R03234	RC00089	ko00000,ko00001,ko01000				Bacteria	1QA80@1224,1RQ2Z@1236,3XN34@561,COG1063@1,COG1063@2	NA|NA|NA	E	oxidoreductase activity
C1_00219	316407.85675741	2e-180	638.3	Escherichia	glpX	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0030145,GO:0030388,GO:0042132,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0046914,GO:0050308,GO:0071704,GO:1901135,GO:1901576	2.2.1.1,3.1.3.11,3.1.3.37	ko:K00615,ko:K02446,ko:K11532	ko00010,ko00030,ko00051,ko00680,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00003,M00004,M00007,M00165,M00167	R00762,R01067,R01641,R01830,R01845,R04780,R06590	RC00017,RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000			iSF_1195.SF2920,iUMNK88_1353.UMNK88_3626,iUMNK88_1353.UMNK88_4762	Bacteria	1R5BK@1224,1S16G@1236,3XPBC@561,COG1494@1,COG1494@2	NA|NA|NA	G	Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate. Also displays a low activity toward glucose 1,6-bisphosphate, and no activity against ribulose 1,5- bisphosphate, fructose 2,6-bisphosphate, or fructose 1-phosphate
C1_00220	1440052.EAKF1_ch3064	2.2e-90	338.2	Escherichia	yggD	GO:0003674,GO:0003824,GO:0004333,GO:0016829,GO:0016835,GO:0016836											Bacteria	1R8G8@1224,1RZD8@1236,3XMB3@561,COG3722@1,COG3722@2	NA|NA|NA	K	In vitro catalyzes the addition of water to fumarate, forming malate. Cannot catalyze the reverse reaction. Cannot use the cis-isomer maleate as substrate
C1_00221	199310.c3511	3.3e-132	477.6	Escherichia	yggC			ko:K02173					ko00000				Bacteria	1RA07@1224,1S2M0@1236,3XNKG@561,COG1072@1,COG1072@2	NA|NA|NA	H	kinase activity
C1_00222	155864.EDL933_4136	2.2e-125	454.9	Escherichia	cysA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008272,GO:0008509,GO:0015075,GO:0015103,GO:0015116,GO:0015318,GO:0015399,GO:0015405,GO:0015419,GO:0015698,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0034220,GO:0040007,GO:0042623,GO:0042626,GO:0043225,GO:0043492,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0072348,GO:0098656,GO:0098660,GO:0098661,GO:0099133,GO:1901682,GO:1902358	3.6.3.25,3.6.3.29	ko:K02017,ko:K02045,ko:K10112,ko:K16787	ko00920,ko02010,map00920,map02010	M00185,M00189,M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00582,M00602,M00605,M00606			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1,3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35,3.A.1.6.1,3.A.1.6.3,3.A.1.8		iE2348C_1286.E2348C_2607	Bacteria	1R6B9@1224,1S0G1@1236,3XMQP@561,COG1118@1,COG1118@2	NA|NA|NA	P	ATPases associated with a variety of cellular activities
C1_00223	155864.EDL933_4135	3.6e-128	464.2	Escherichia				ko:K02006,ko:K16784,ko:K16785,ko:K16786,ko:K16787,ko:K21397	ko02010,map02010	M00245,M00246,M00581,M00582			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.18,3.A.1.22,3.A.1.23,3.A.1.25,3.A.1.25.1,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35			Bacteria	1R88Q@1224,1S4TQ@1236,3XMCN@561,COG1122@1,COG1122@2	NA|NA|NA	P	ABC transporter
C1_00224	155864.EDL933_4134	8.9e-130	469.5	Escherichia	ecfT	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015238,GO:0015711,GO:0015893,GO:0016020,GO:0022857,GO:0032217,GO:0032218,GO:0034220,GO:0035461,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051180,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0090482,GO:0098656		ko:K02008,ko:K16783,ko:K16785	ko02010,map02010	M00245,M00246,M00581,M00582			ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23,3.A.1.25,3.A.1.25.1,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35			Bacteria	1RA5H@1224,1S2XN@1236,3XP0C@561,COG0619@1,COG0619@2	NA|NA|NA	P	Psort location CytoplasmicMembrane, score
C1_00225	198214.SF2914	8.7e-83	313.2	Gammaproteobacteria			2.7.7.65	ko:K16923,ko:K18967		M00582			ko00000,ko00002,ko01000,ko02000	3.A.1.28,9.B.34.1.1			Bacteria	1R7I7@1224,1RQ5Z@1236,COG3275@1,COG3275@2	NA|NA|NA	T	phosphorelay sensor kinase activity
C1_00226	155864.EDL933_4132	6.9e-77	293.1	Escherichia				ko:K06934					ko00000				Bacteria	1RIME@1224,1S71M@1236,3XPPV@561,COG1661@1,COG1661@2	NA|NA|NA	S	Domain of unknown function (DUF296)
C1_00227	155864.EDL933_4131	2.4e-192	677.9	Escherichia	epd	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0018130,GO:0019318,GO:0019438,GO:0019637,GO:0034641,GO:0036094,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043891,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0048001,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	1.2.1.12,1.2.1.72	ko:K00134,ko:K03472	ko00010,ko00710,ko00750,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map00750,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00124,M00165,M00166,M00308,M00552	R01061,R01825	RC00149,RC00242	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147			iAPECO1_1312.APECO1_847,iJR904.b1416,iJR904.b1417,iUTI89_1310.UTI89_C1975,iYL1228.KPN_03356,ic_1306.c2184	Bacteria	1MU93@1224,1RMBM@1236,3XN8W@561,COG0057@1,COG0057@2	NA|NA|NA	H	Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate
C1_00228	1440052.EAKF1_ch3067	9e-212	742.7	Escherichia	pgk	GO:0003674,GO:0003824,GO:0004618,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147			iSbBS512_1146.SbBS512_E3351	Bacteria	1MUNU@1224,1RMUQ@1236,3XN0J@561,COG0126@1,COG0126@2	NA|NA|NA	F	Belongs to the phosphoglycerate kinase family
C1_00229	155864.EDL933_4129	1.4e-206	725.3	Escherichia	fbaA	GO:0003674,GO:0003824,GO:0004332,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016830,GO:0016832,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030312,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035375,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000			iZ_1308.Z4263	Bacteria	1MURX@1224,1RQUC@1236,3XMVJ@561,COG0191@1,COG0191@2	NA|NA|NA	F	Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis
C1_00230	155864.EDL933_4128	3.8e-135	487.6	Escherichia	mscS	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022607,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0034220,GO:0042592,GO:0042802,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055082,GO:0055085,GO:0065003,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066		ko:K03442					ko00000,ko02000	1.A.23.2			Bacteria	1N596@1224,1RQZP@1236,3XMPN@561,COG0668@1,COG0668@2	NA|NA|NA	M	Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage
C1_00231	199310.c3501	2.9e-116	424.5	Escherichia	argO	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015174,GO:0015181,GO:0015318,GO:0015711,GO:0015802,GO:0015807,GO:0015809,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902023,GO:1903825,GO:1903826,GO:1905039,GO:1990822		ko:K06895					ko00000,ko02000	2.A.75.1		iPC815.YPO0918	Bacteria	1RD6B@1224,1RR03@1236,3XN2X@561,COG1279@1,COG1279@2	NA|NA|NA	S	Involved in the export of arginine. Important to control the intracellular level of arginine and the correct balance between arginine and lysine
C1_00232	155864.EDL933_4126	1.3e-128	465.7	Escherichia	yggE	GO:0000302,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031233,GO:0033554,GO:0034599,GO:0034605,GO:0034614,GO:0042221,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0070887,GO:0071575,GO:0071944,GO:0098552,GO:1901700,GO:1901701		ko:K09807					ko00000				Bacteria	1RH7T@1224,1RP7T@1236,3XNCG@561,COG2968@1,COG2968@2	NA|NA|NA	S	cellular response to heat
C1_00233	316407.85675732	1.6e-168	598.6	Escherichia	ygfI	GO:0003674,GO:0003700,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141											Bacteria	1R44I@1224,1S19F@1236,3XN51@561,COG0583@1,COG0583@2	NA|NA|NA	K	DNA-binding transcription factor activity
C1_00234	481805.EcolC_0790	6.1e-282	976.1	Escherichia	cat1	GO:0003674,GO:0003824,GO:0003986,GO:0006082,GO:0006083,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008410,GO:0008775,GO:0009987,GO:0016289,GO:0016740,GO:0016782,GO:0016787,GO:0016788,GO:0016790,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0043821,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0046459,GO:0071704	2.8.3.18,3.1.2.1	ko:K01067,ko:K18118,ko:K22214	ko00020,ko00620,ko00640,ko00650,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00640,map00650,map01100,map01110,map01120,map01130,map01200	M00009,M00011	R00227,R10343,R11773	RC00004,RC00012,RC00014	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_1125,iECIAI1_1343.ECIAI1_3040,iECSE_1348.ECSE_3182,iECW_1372.ECW_m3175,iEKO11_1354.EKO11_0812,iWFL_1372.ECW_m3175	Bacteria	1MUGE@1224,1RP19@1236,3XMWJ@561,COG0427@1,COG0427@2	NA|NA|NA	C	Catalyzes the transfer of coenzyme A from propionyl-CoA to succinate. Could be part of a pathway that converts succinate to propionate
C1_00235	198214.SF2904	5.4e-144	516.9	Gammaproteobacteria	scpB	GO:0003674,GO:0003824,GO:0004300,GO:0004492,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016829,GO:0016830,GO:0016831,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	4.1.1.41	ko:K11264	ko00640,map00640		R00923	RC00097	ko00000,ko00001,ko01000			iSSON_1240.SSON_3070	Bacteria	1R3SQ@1224,1RR23@1236,COG1024@1,COG1024@2	NA|NA|NA	I	Belongs to the enoyl-CoA hydratase isomerase family
C1_00236	316407.85675729	1.4e-181	642.1	Escherichia	argK	GO:0003674,GO:0003824,GO:0003924,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111		ko:K07588					ko00000,ko01000				Bacteria	1MVI0@1224,1RP15@1236,3XP3F@561,COG1703@1,COG1703@2	NA|NA|NA	E	Binds and hydrolyzes GTP. Likely functions as a G-protein chaperone that assists AdoCbl cofactor delivery to the methylmalonyl-CoA mutase (MCM) ScpA and reactivation of the enzyme during catalysis
C1_00237	155864.EDL933_4120	0.0	1386.3	Escherichia	scpA	GO:0003674,GO:0003824,GO:0004494,GO:0005488,GO:0008144,GO:0016853,GO:0016866,GO:0019842,GO:0031419,GO:0036094,GO:0046906,GO:0048037,GO:0097159,GO:1901363	5.4.99.2	ko:K01847,ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000			iECO111_1330.ECO111_3653,iECO26_1355.ECO26_4004	Bacteria	1MUXX@1224,1RSHX@1236,3XMZG@561,COG1884@1,COG1884@2,COG2185@1,COG2185@2	NA|NA|NA	I	Methylmalonyl-CoA mutase
C1_00238	155864.EDL933_4119	2.3e-167	594.7	Escherichia	argP	GO:0003674,GO:0003676,GO:0003677,GO:0003681,GO:0003700,GO:0005488,GO:0006275,GO:0006355,GO:0008150,GO:0008156,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0030174,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032297,GO:0043565,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0090329,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000104,GO:2000112,GO:2000113,GO:2001141		ko:K05596					ko00000,ko03000,ko03036				Bacteria	1MWUP@1224,1RNIC@1236,3XMCC@561,COG0583@1,COG0583@2	NA|NA|NA	K	Controls the transcription of genes involved in arginine and lysine metabolism
C1_00239	693444.D782_1039	1.9e-09	68.2	Gammaproteobacteria													Bacteria	1MXDQ@1224,1SYJV@1236,COG0583@1,COG0583@2	NA|NA|NA	K	transcriptional regulator
C1_00240	155864.EDL933_4117	1.8e-116	425.2	Escherichia	rpiA	GO:0003674,GO:0003824,GO:0004751,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0042802,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000				Bacteria	1MVGR@1224,1RNF8@1236,3XMIS@561,COG0120@1,COG0120@2	NA|NA|NA	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C1_00241	155864.EDL933_4115	1.2e-230	805.4	Escherichia	serA	GO:0003674,GO:0003824,GO:0004617,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006807,GO:0008150,GO:0008152,GO:0008219,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0012501,GO:0016053,GO:0016491,GO:0016597,GO:0016614,GO:0016616,GO:0019752,GO:0031406,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0047545,GO:0055114,GO:0070905,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147			iYL1228.KPN_03348	Bacteria	1MU5Z@1224,1RPEY@1236,3XNAF@561,COG0111@1,COG0111@2	NA|NA|NA	E	Catalyzes the reversible oxidation of 3-phospho-D- glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate
C1_00242	155864.EDL933_4114	3.2e-112	411.0	Escherichia	fthC	GO:0003674,GO:0003824,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019752,GO:0022611,GO:0030272,GO:0032502,GO:0034641,GO:0035999,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100		R02301	RC00183	ko00000,ko00001,ko01000			iECABU_c1320.ECABU_c31940,iECOK1_1307.ECOK1_3298,iECSF_1327.ECSF_2705,iUTI89_1310.UTI89_C3298	Bacteria	1MZG0@1224,1S612@1236,3XN1C@561,COG0212@1,COG0212@2	NA|NA|NA	H	Involved in the removal of 5-formyltetrahydrofolate. In vitro, it is a potent inhibitor of various folate-dependent enzymes in the C1 metabolism network and in vivo it might function as a folate storage. 5-formyltetrahydrofolate is also used as an antifolate rescue agent in cancer chemotherapy. Catalyzes the irreversible ATP-dependent transformation of 5- formyltetrahydrofolate (5-CHO-THF) to form 5,10- methenyltetrahydrofolate (5,10-CH THF). The reverse reaction is catalyzed by the serine hydroxymethyltransferase GlyA (SHMT)
C1_00243	1440052.EAKF1_ch3084c	6.5e-51	206.5	Escherichia	zapA	GO:0000003,GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0000921,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0007010,GO:0007049,GO:0008150,GO:0009987,GO:0016043,GO:0019954,GO:0022402,GO:0022414,GO:0022607,GO:0030428,GO:0031106,GO:0032153,GO:0032185,GO:0032505,GO:0032506,GO:0034622,GO:0042802,GO:0043093,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0051301,GO:0061640,GO:0065003,GO:0070925,GO:0071840,GO:0090529,GO:1902410,GO:1903047		ko:K09888					ko00000,ko03036				Bacteria	1N6YN@1224,1SCBI@1236,3XPRT@561,COG3027@1,COG3027@2	NA|NA|NA	D	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
C1_00244	198214.SF2895	1.9e-106	391.7	Gammaproteobacteria	ygfB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K09895					ko00000				Bacteria	1N7W0@1224,1SCPW@1236,COG3079@1,COG3079@2	NA|NA|NA	S	Belongs to the UPF0149 family
C1_00245	199310.c3490	2.2e-254	884.4	Escherichia	pepP	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0016787,GO:0019538,GO:0030145,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.11.9	ko:K01262					ko00000,ko01000,ko01002				Bacteria	1MUZS@1224,1RN0W@1236,3XN21@561,COG0006@1,COG0006@2	NA|NA|NA	E	metalloexopeptidase activity
C1_00246	469008.B21_02702	9.1e-220	769.2	Escherichia	ubiH	GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008681,GO:0009058,GO:0009108,GO:0009314,GO:0009416,GO:0009628,GO:0009987,GO:0016491,GO:0016705,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0050896,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901576,GO:1901661,GO:1901663		ko:K03184,ko:K03185,ko:K18800	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04987,R04989,R06146,R08768,R08773,R08775	RC00046,RC01254,RC02670	ko00000,ko00001,ko00002,ko01000			iAF1260.b0662,iB21_1397.B21_02702,iBWG_1329.BWG_0533,iECBD_1354.ECBD_0830,iECB_1328.ECB_02739,iECDH10B_1368.ECDH10B_0731,iECDH1ME8569_1439.ECDH1ME8569_0631,iECD_1391.ECD_02739,iETEC_1333.ETEC_0690,iEcDH1_1363.EcDH1_2964,iEcHS_1320.EcHS_A0709,iEcHS_1320.EcHS_A3066,iJO1366.b0662,iJR904.b0662,iUMNK88_1353.UMNK88_700,iY75_1357.Y75_RS03450	Bacteria	1MU6I@1224,1RMS3@1236,3XNK9@561,COG0654@1,COG0654@2	NA|NA|NA	CH	2-octaprenyl-6-methoxyphenol hydroxylase
C1_00247	469008.B21_02701	2.2e-229	801.2	Escherichia	visC	GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016491,GO:0019168,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901576,GO:1901661,GO:1901663		ko:K03184,ko:K03185,ko:K18800	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04987,R04989,R06146,R08768,R08773,R08775	RC00046,RC01254,RC02670	ko00000,ko00001,ko00002,ko01000			iAF1260.b0662,iB21_1397.B21_02702,iBWG_1329.BWG_0533,iECBD_1354.ECBD_0830,iECB_1328.ECB_02739,iECDH10B_1368.ECDH10B_0731,iECDH1ME8569_1439.ECDH1ME8569_0631,iECD_1391.ECD_02739,iETEC_1333.ETEC_0690,iEcDH1_1363.EcDH1_2964,iEcHS_1320.EcHS_A0709,iEcHS_1320.EcHS_A3066,iJO1366.b0662,iJR904.b0662,iUMNK88_1353.UMNK88_700,iY75_1357.Y75_RS03450	Bacteria	1MU6I@1224,1RND5@1236,3XMGD@561,COG0654@1,COG0654@2	NA|NA|NA	CH	FAD-dependent monooxygenase required for the aerobic hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy- phenol, the first hydroxylation step in coenzyme Q (ubiquinone) biosynthesis
C1_00248	316407.85675717	8.7e-209	732.6	Escherichia	gcvT	GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000			iSFV_1184.SFV_2953	Bacteria	1MV96@1224,1RN2A@1236,3XMM9@561,COG0404@1,COG0404@2	NA|NA|NA	E	The glycine cleavage system catalyzes the degradation of glycine
C1_00249	155864.EDL933_4106	1.6e-64	251.9	Escherichia	gcvH	GO:0001505,GO:0003674,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0017144,GO:0019464,GO:0019752,GO:0031405,GO:0031406,GO:0033293,GO:0036094,GO:0042133,GO:0042135,GO:0042737,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901681		ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002			iE2348C_1286.E2348C_3156,iPC815.YPO0906	Bacteria	1RGV7@1224,1S656@1236,3XPN3@561,COG0509@1,COG0509@2	NA|NA|NA	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein
C1_00250	155864.EDL933_4105	0.0	1891.3	Escherichia	gcvP	GO:0003674,GO:0003824,GO:0004375,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016638,GO:0016642,GO:0030312,GO:0040007,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944	1.4.4.2	ko:K00281,ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000			iECIAI39_1322.ECIAI39_3318	Bacteria	1MUDP@1224,1RND3@1236,3XM76@561,COG0403@1,COG0403@2,COG1003@1,COG1003@2	NA|NA|NA	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1_00251	316407.85675714	1.5e-132	478.8	Escherichia													Bacteria	1MW9A@1224,1RMMZ@1236,3XP5I@561,COG1028@1,COG1028@2	NA|NA|NA	IQ	oxidoreductase activity
C1_00252	481805.EcolC_0808	8.8e-294	1015.4	Escherichia	bglA	GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008422,GO:0015926,GO:0016787,GO:0016798,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901135,GO:1901657	3.2.1.86	ko:K01223	ko00010,ko00500,map00010,map00500		R00839,R05133,R05134	RC00049,RC00171,RC00714	ko00000,ko00001,ko01000		GT1	iEC55989_1330.EC55989_3188,iSSON_1240.SSON_3054	Bacteria	1MWG6@1224,1RMM2@1236,3XM82@561,COG2723@1,COG2723@2	NA|NA|NA	G	Belongs to the glycosyl hydrolase 1 family
C1_00253	469008.B21_02695	9.5e-52	209.1	Escherichia	yqfB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K09900					ko00000				Bacteria	1N1TE@1224,1SB7Z@1236,3XPR9@561,COG3097@1,COG3097@2	NA|NA|NA	S	Belongs to the UPF0267 family
C1_00254	155864.EDL933_4102	2.9e-114	417.9	Escherichia	yqfA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K11068					ko00000,ko02042				Bacteria	1PGRH@1224,1RR4R@1236,3XMNM@561,COG1272@1,COG1272@2	NA|NA|NA	S	UPF0073 inner membrane protein YqfA
C1_00255	198214.SF2884	1.1e-183	649.0	Gammaproteobacteria	ygfZ	GO:0003674,GO:0005488,GO:0005542,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0019842,GO:0022607,GO:0031163,GO:0031406,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0071840,GO:0072341,GO:0097159,GO:1901363		ko:K06980,ko:K22073					ko00000,ko01000,ko03016,ko03029				Bacteria	1N852@1224,1RPWB@1236,COG0354@1,COG0354@2	NA|NA|NA	S	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication
C1_00256	1440052.EAKF1_ch3100	1.5e-45	188.3	Escherichia	sdhE	GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006105,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016043,GO:0016999,GO:0017013,GO:0017144,GO:0018065,GO:0018293,GO:0019538,GO:0019752,GO:0022607,GO:0034552,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0043648,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0045333,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072350,GO:1901564	1.3.5.1,1.3.5.4	ko:K00240,ko:K09159	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000,ko02048				Bacteria	1N7P4@1224,1SCKB@1236,3XPU9@561,COG2938@1,COG2938@2	NA|NA|NA	S	Flavinator of succinate dehydrogenase
C1_00257	316407.85675708	2e-70	271.6	Escherichia	ygfX	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016021,GO:0016999,GO:0017000,GO:0017144,GO:0031224,GO:0031226,GO:0032091,GO:0043393,GO:0044092,GO:0044237,GO:0044249,GO:0044425,GO:0044459,GO:0044464,GO:0051098,GO:0051100,GO:0065007,GO:0065009,GO:0071944		ko:K19168					ko00000,ko02048				Bacteria	1RDS7@1224,1S3W7@1236,295KK@1,2ZSY3@2,3XPKK@561	NA|NA|NA	S	inner membrane protein. Has been shown not to be a toxin, no effects on growth are seen in LB or minimal medium up to 6 or 21 hours (respectively) after induction of expression. Interacts with cytoskeletal proteins FtsZ and MreB
C1_00258	155864.EDL933_4097	1e-98	365.9	Escherichia	fldB	GO:0000166,GO:0003674,GO:0005488,GO:0010181,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K03839,ko:K03840					ko00000			iEcSMS35_1347.EcSMS35_3028,iJN678.isiB,iYL1228.KPN_03323	Bacteria	1QRBW@1224,1RMED@1236,3XMVZ@561,COG0716@1,COG0716@2	NA|NA|NA	C	Low-potential electron donor to a number of redox enzymes
C1_00259	1440052.EAKF1_ch3103	2.8e-165	587.8	Escherichia	xerD	GO:0000150,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009314,GO:0009628,GO:0009987,GO:0015074,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0071139,GO:0071704,GO:0090304,GO:0140097,GO:1901360		ko:K04763					ko00000,ko03036				Bacteria	1MVNF@1224,1RPI8@1236,3XNCQ@561,COG4974@1,COG4974@2	NA|NA|NA	L	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Binds cooperatively to specific DNA consensus sequences that are separated from XerC binding sites by a short central region, forming the heterotetrameric XerC-XerD complex that recombines DNA substrates. The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids
C1_00260	155864.EDL933_4095	6.2e-131	473.4	Escherichia	dsbC	GO:0003674,GO:0003756,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0055114,GO:0140096	5.3.4.1	ko:K03805,ko:K03981					ko00000,ko01000,ko02044,ko03110	3.A.7.11.1		iE2348C_1286.E2348C_3146,iEC042_1314.EC042_3104,iEcSMS35_1347.EcSMS35_3026,iG2583_1286.G2583_0768,iPC815.YPO0891,iSFV_1184.SFV_2941,iSF_1195.SF2879,iSFxv_1172.SFxv_3158,iS_1188.S3078	Bacteria	1RD39@1224,1S3U8@1236,3XP20@561,COG1651@1,COG1651@2	NA|NA|NA	O	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C1_00261	469008.B21_02687	0.0	1146.7	Escherichia	recJ	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008297,GO:0008409,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0035312,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0045145,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360		ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440				ko00000,ko00001,ko01000,ko03400				Bacteria	1MU1M@1224,1RMF4@1236,3XP91@561,COG0608@1,COG0608@2	NA|NA|NA	L	single-stranded-DNA-specific exonuclease RecJ
C1_00262	155864.EDL933_4092	2.7e-160	571.2	Escherichia	prfB	GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576		ko:K02836					ko00000,ko03012				Bacteria	1MUAW@1224,1RP9Z@1236,3XNW7@561,COG1186@1,COG1186@2	NA|NA|NA	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C1_00263	199310.c3469	2.2e-290	1004.2	Escherichia	lysS	GO:0003674,GO:0003824,GO:0004812,GO:0004824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006430,GO:0006518,GO:0006520,GO:0006629,GO:0006644,GO:0006650,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009059,GO:0009405,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019637,GO:0019752,GO:0030312,GO:0030322,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042221,GO:0042391,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046471,GO:0046483,GO:0046486,GO:0046677,GO:0050896,GO:0051704,GO:0065007,GO:0065008,GO:0071704,GO:0071944,GO:0090304,GO:0090407,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iAF1260.b4129,iECDH1ME8569_1439.ECDH1ME8569_3989,iECW_1372.ECW_m4490,iEcDH1_1363.EcDH1_3862,iJN678.lysS,iJO1366.b4129,iWFL_1372.ECW_m4490	Bacteria	1MX1V@1224,1RMJN@1236,3XM7X@561,COG1190@1,COG1190@2	NA|NA|NA	J	Belongs to the class-II aminoacyl-tRNA synthetase family
C1_00264	469008.B21_02684	1.1e-103	382.5	Escherichia	idi	GO:0003674,GO:0003824,GO:0004452,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016853,GO:0016860,GO:0016863,GO:0019637,GO:0033554,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0046490,GO:0050896,GO:0051716,GO:0071704,GO:0090407,GO:1901576	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000			iECH74115_1262.ECH74115_4179,iECIAI1_1343.ECIAI1_3008,iECO103_1326.ECO103_3464,iECSP_1301.ECSP_3858,iECs_1301.ECs3761,iEcE24377_1341.EcE24377A_3215,iG2583_1286.G2583_3542,iSFV_1184.SFV_2937,iSF_1195.SF2875,iSFxv_1172.SFxv_3153,iSSON_1240.SSON_3042,iS_1188.S3074,iZ_1308.Z4227	Bacteria	1R9YJ@1224,1S6ZT@1236,3XNXM@561,COG1443@1,COG1443@2	NA|NA|NA	I	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C1_00265	199310.c3466	1.9e-11	73.9	Escherichia													Bacteria	1QITG@1224,1TGP0@1236,2AV7P@1,31KYB@2,3XREE@561	NA|NA|NA		
C1_00266	316407.85675700	1.1e-262	912.1	Escherichia	ygfU	GO:0003674,GO:0005215,GO:0005345,GO:0005350,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006206,GO:0006208,GO:0006212,GO:0006725,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006863,GO:0008150,GO:0008152,GO:0008324,GO:0008509,GO:0008514,GO:0009056,GO:0009112,GO:0009987,GO:0015075,GO:0015143,GO:0015205,GO:0015210,GO:0015238,GO:0015711,GO:0015747,GO:0015851,GO:0015855,GO:0015857,GO:0015893,GO:0016020,GO:0016021,GO:0017144,GO:0019860,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0034641,GO:0042221,GO:0042493,GO:0042737,GO:0042906,GO:0042907,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0072527,GO:0072529,GO:0072530,GO:0072531,GO:0098655,GO:0098656,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901702,GO:1903791,GO:1904082,GO:1904823		ko:K02824,ko:K09016,ko:K16345,ko:K16346					ko00000,ko02000	2.A.40.1.1,2.A.40.1.2,2.A.40.1.3,2.A.40.4.2,2.A.40.4.3		iECO103_1326.ECO103_1052,iG2583_1286.G2583_3536,iSDY_1059.SDY_4086,iSFxv_1172.SFxv_2795,iS_1188.S2690	Bacteria	1MUN9@1224,1RMGW@1236,3XM66@561,COG2233@1,COG2233@2	NA|NA|NA	F	Proton-dependent high-capacity transporter for uric acid. Shows also a low capacity for transport of xanthine at 37 degrees Celsius but not at 25 degrees Celsius
C1_00267	316407.85675699	0.0	1303.9	Escherichia	gltD	GO:0003674,GO:0003824,GO:0004355,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009055,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0022900,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045181,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14	ko:K00266,ko:K05796,ko:K12136,ko:K15827	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230		R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000			iEC042_1314.EC042_3503,iSSON_1240.SSON_2871	Bacteria	1MU2H@1224,1RMY7@1236,3XNDT@561,COG0493@1,COG0493@2,COG1142@1,COG1142@2	NA|NA|NA	C	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
C1_00268	316407.85675698	1.2e-80	305.8	Escherichia	ygfS	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0044237,GO:0044424,GO:0044464,GO:0055114		ko:K05796,ko:K12136,ko:K15827					ko00000,ko01000			iSSON_1240.SSON_2871	Bacteria	1MWE1@1224,1S33B@1236,3XQP5@561,COG1142@1,COG1142@2	NA|NA|NA	C	4 iron, 4 sulfur cluster binding
C1_00269	155864.EDL933_4085	1.3e-238	832.0	Escherichia	pbuG	GO:0003674,GO:0005215,GO:0005345,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006863,GO:0008150,GO:0015205,GO:0015208,GO:0015851,GO:0015854,GO:0016020,GO:0022857,GO:0035344,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072530,GO:0098657,GO:0098710,GO:0098739,GO:1903716,GO:1904823		ko:K06901					ko00000,ko02000	2.A.1.40		iECH74115_1262.ECH74115_5145,iECSP_1301.ECSP_4762,iECs_1301.ECs4651,iG2583_1286.G2583_4505,iZ_1308.Z5209	Bacteria	1MUV0@1224,1RMBE@1236,3XNZX@561,COG2252@1,COG2252@2	NA|NA|NA	S	guanine transport
C1_00270	481805.EcolC_0825	9.1e-261	905.6	Escherichia	guaD	GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006144,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008892,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0016814,GO:0018756,GO:0019239,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0046098,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072521,GO:1901360,GO:1901564	3.5.4.3	ko:K01487	ko00230,ko01100,map00230,map01100		R01676	RC00204	ko00000,ko00001,ko01000			iEC55989_1330.EC55989_3170,iECED1_1282.ECED1_3343,iECIAI1_1343.ECIAI1_3003,iECSE_1348.ECSE_3147	Bacteria	1MUPT@1224,1SYCI@1236,3XMAR@561,COG0402@1,COG0402@2	NA|NA|NA	F	guanine catabolic process
C1_00271	155864.EDL933_4083	4.5e-250	870.2	Escherichia	pbuX	GO:0003674,GO:0005215,GO:0005345,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006863,GO:0008150,GO:0015205,GO:0015851,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0042906,GO:0042907,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072530,GO:1904823		ko:K02824,ko:K03458,ko:K09016,ko:K16345,ko:K16346					ko00000,ko02000	2.A.40,2.A.40.1.1,2.A.40.1.2,2.A.40.1.3,2.A.40.4.2,2.A.40.4.3		iECO103_1326.ECO103_1052,iG2583_1286.G2583_3536,iSDY_1059.SDY_4086,iSFxv_1172.SFxv_2795,iS_1188.S2690	Bacteria	1MUN9@1224,1RMGW@1236,3XM9S@561,COG2233@1,COG2233@2	NA|NA|NA	F	Specific, proton motive force-dependent high-affinity transporter for xanthine
C1_00272	481805.EcolC_0827	0.0	1927.5	Escherichia	xdhD	GO:0003674,GO:0005488,GO:0005506,GO:0043167,GO:0043169,GO:0046872,GO:0046914	1.17.1.4,1.3.99.16	ko:K00087,ko:K07302,ko:K12528,ko:K13480,ko:K13483	ko00230,ko00450,ko01100,ko01120,map00230,map00450,map01100,map01120	M00546	R01768,R02103,R07229	RC00143,RC02420	ko00000,ko00001,ko00002,ko01000			iECH74115_1262.ECH74115_4158,iECSP_1301.ECSP_3838,iECs_1301.ECs3741,iEcHS_1320.EcHS_A3026,iZ_1308.Z4207	Bacteria	1MUEA@1224,1RN40@1236,3XM8S@561,COG1529@1,COG1529@2,COG2080@1,COG2080@2	NA|NA|NA	F	however deletion results in increased adenine sensitivity, suggesting that this protein contributes to the conversion of adenine to guanine nucleotides during purine salvage
C1_00273	155864.EDL933_4081	1.2e-140	505.8	Escherichia	ygfM		1.17.1.4,1.2.5.3	ko:K00087,ko:K03519,ko:K12529	ko00230,ko00450,ko01100,ko01120,map00230,map00450,map01100,map01120	M00546	R01768,R02103,R07229,R11168	RC00143,RC02420,RC02800	ko00000,ko00001,ko00002,ko01000				Bacteria	1Q59D@1224,1RZFY@1236,3XPGK@561,COG1319@1,COG1319@2	NA|NA|NA	C	flavin adenine dinucleotide binding
C1_00274	199310.c3457	3.4e-255	887.1	Escherichia	ssnA												Bacteria	1MVPA@1224,1TFX9@1236,3XM8H@561,COG0402@1,COG0402@2	NA|NA|NA	F	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
C1_00275	316407.85675691	0.0	2104.7	Escherichia	ygfK	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0055114	1.97.1.9	ko:K12527	ko00450,map00450		R07229	RC02420	ko00000,ko00001,ko01000				Bacteria	1MU2H@1224,1RREP@1236,3XNXA@561,COG0493@1,COG0493@2,COG1145@1,COG1145@2	NA|NA|NA	C	Could be an iron-sulfur flavoprotein with NADPH O(2) oxidoreductase activity
C1_00276	316407.85675690	1e-107	396.0	Escherichia	mocA	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019538,GO:0019637,GO:0019720,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061602,GO:0070567,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902759,GO:1902760	1.1.1.328,2.7.7.76	ko:K07141,ko:K19190	ko00760,ko00790,ko01120,map00760,map00790,map01120		R10131,R10132,R11582	RC03053	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_3649,iB21_1397.B21_02672,iECABU_c1320.ECABU_c31580,iECBD_1354.ECBD_0860,iECB_1328.ECB_02710,iECD_1391.ECD_02710,iEcHS_1320.EcHS_A3037	Bacteria	1QE5N@1224,1S3GJ@1236,3XN3C@561,COG2068@1,COG2068@2	NA|NA|NA	S	Transfers a CMP moiety from CTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin cytosine dinucleotide (Mo-MCD) cofactor. Is specific for CTP
C1_00277	316407.85675689	5.1e-147	526.9	Escherichia	murE	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.10,6.3.2.13	ko:K01928,ko:K15792	ko00300,ko00550,map00300,map00550		R02788,R04617	RC00064,RC00090,RC00141	ko00000,ko00001,ko01000,ko01011			ic_1306.c0103	Bacteria	1N1DB@1224,1S7DT@1236,3XNRG@561,COG0769@1,COG0769@2	NA|NA|NA	M	ATP binding
C1_00278	316407.85675688	6.7e-306	1055.8	Escherichia	yqeB	GO:0003674,GO:0005488,GO:0043546,GO:0048037,GO:0050662,GO:0097159,GO:1901363		ko:K07402					ko00000				Bacteria	1MWFN@1224,1T1CW@1236,3XM3Q@561,COG1975@1,COG1975@2,COG3608@1,COG3608@2	NA|NA|NA	O	XdhC and CoxI family
C1_00279	316407.85675687	6.4e-168	596.7	Escherichia	arcC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200		R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_3652,iECABU_c1320.ECABU_c31550,iECED1_1282.ECED1_3334,iECIAI39_1322.ECIAI39_3289,iECNA114_1301.ECNA114_2915,iECOK1_1307.ECOK1_3260,iECS88_1305.ECS88_3153,iECSF_1327.ECSF_2670,iEcE24377_1341.EcE24377A_0559,iEcHS_1320.EcHS_A0383,iUMN146_1321.UM146_02150,iUTI89_1310.UTI89_C3259,ic_1306.c3452	Bacteria	1MWXC@1224,1RP78@1236,3XN33@561,COG0549@1,COG0549@2	NA|NA|NA	E	Belongs to the carbamate kinase family
C1_00280	155864.EDL933_4074	1.9e-272	944.5	Escherichia	hyuA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0016787,GO:0016810,GO:0016812,GO:0042802	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	1MW10@1224,1RMQC@1236,3XMJE@561,COG0044@1,COG0044@2	NA|NA|NA	F	Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin derivatives with an aromatic side chains at the 5'-position. Has no activity on dihydropyrimidines. The physiological function is
C1_00281	155864.EDL933_4073	8.1e-240	835.9	Escherichia	ygeY												Bacteria	1N20R@1224,1RYRN@1236,3XNF6@561,COG0624@1,COG0624@2	NA|NA|NA	E	metallopeptidase activity
C1_00282	155864.EDL933_4072	5.2e-231	806.6	Escherichia	ygeX	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008838,GO:0009056,GO:0009063,GO:0009987,GO:0016054,GO:0016829,GO:0016840,GO:0016841,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575	4.3.1.15,4.3.1.19	ko:K01751,ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_2699,iECED1_1282.ECED1_3331	Bacteria	1QTY3@1224,1RPCW@1236,3XN3A@561,COG1171@1,COG1171@2	NA|NA|NA	E	Catalyzes the alpha,beta-elimination reaction of both L- and D-alpha,beta-diaminopropionate (DAP) to form pyruvate and ammonia
C1_00283	155864.EDL933_4071	2.2e-226	791.2	Escherichia	ygeW	GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0019627,GO:0034641,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000			iECS88_1305.ECS88_4841	Bacteria	1N4DE@1224,1RSHV@1236,3XPB7@561,COG0078@1,COG0078@2	NA|NA|NA	F	carbamoyltransferase YgeW
C1_00284	481805.EcolC_0839	0.0	1149.4	Escherichia	ygeV	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576											Bacteria	1NU8B@1224,1RMHY@1236,3XN69@561,COG3829@1,COG3829@2	NA|NA|NA	K	transcriptional regulator
C1_00285	316407.85675681	4.4e-88	330.5	Escherichia	xdhC	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0051536,GO:0051537,GO:0051540,GO:0055114	1.2.5.3,1.3.99.16	ko:K03518,ko:K07302,ko:K12528,ko:K13480,ko:K13483	ko00230,ko00450,ko01100,ko01120,map00230,map00450,map01100,map01120	M00546	R01768,R02103,R07229,R11168	RC00143,RC02420,RC02800	ko00000,ko00001,ko00002,ko01000			iECH74115_1262.ECH74115_4158,iECSP_1301.ECSP_3838,iECs_1301.ECs3741,iZ_1308.Z4207	Bacteria	1RD8C@1224,1S40Y@1236,3XNQJ@561,COG2080@1,COG2080@2	NA|NA|NA	F	Xanthine dehydrogenase iron-sulfur-binding subunit
C1_00286	316407.85675680	2.4e-164	584.7	Escherichia	xdhB	GO:0000166,GO:0003674,GO:0003824,GO:0004854,GO:0005488,GO:0006139,GO:0006144,GO:0006145,GO:0006150,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009114,GO:0009987,GO:0016491,GO:0016725,GO:0016726,GO:0019439,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0046100,GO:0046113,GO:0046483,GO:0046700,GO:0048037,GO:0050660,GO:0050662,GO:0055086,GO:0055114,GO:0071704,GO:0071949,GO:0072521,GO:0072523,GO:0097159,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575	1.17.1.4	ko:K13479	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000			iLF82_1304.LF82_2444,iNRG857_1313.NRG857_14070,iS_1188.S3069	Bacteria	1RCRH@1224,1T26M@1236,3XN3Q@561,COG1319@1,COG1319@2	NA|NA|NA	F	Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism)
C1_00287	481805.EcolC_0842	0.0	1520.0	Escherichia	xdhA	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114	1.17.1.4	ko:K00087,ko:K12528	ko00230,ko00450,ko01100,ko01120,map00230,map00450,map01100,map01120	M00546	R01768,R02103,R07229	RC00143,RC02420	ko00000,ko00001,ko00002,ko01000			iEcHS_1320.EcHS_A3026	Bacteria	1MUEA@1224,1RN40@1236,3XQ6N@561,COG1529@1,COG1529@2	NA|NA|NA	F	Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism)
C1_00288	155864.EDL933_4066	3.5e-132	477.6	Escherichia	nlpD	GO:0000920,GO:0001896,GO:0008150,GO:0008219,GO:0009987,GO:0012501,GO:0051301		ko:K06194,ko:K12943					ko00000	1.A.34.1.2			Bacteria	1RD24@1224,1RR11@1236,3XNB1@561,COG4942@1,COG4942@2	NA|NA|NA	M	autolysis
C1_00291	316407.1736794	2.8e-170	604.4	Gammaproteobacteria		GO:0008150,GO:0009987,GO:0032196		ko:K07497					ko00000				Bacteria	1MVXQ@1224,1RR4F@1236,COG2801@1,COG2801@2	NA|NA|NA	L	COG2801 Transposase and inactivated derivatives
C1_00292	1440052.EAKF1_ch3017c	4.5e-43	180.3	Escherichia		GO:0005575,GO:0005623,GO:0008150,GO:0009279,GO:0009405,GO:0016020,GO:0019867,GO:0030260,GO:0030312,GO:0030313,GO:0031975,GO:0044403,GO:0044409,GO:0044419,GO:0044462,GO:0044464,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0071944		ko:K07483					ko00000				Bacteria	1RHBZ@1224,1S69Y@1236,3XR2P@561,COG2963@1,COG2963@2	NA|NA|NA	L	transposase activity
C1_00293	469008.B21_02657	3.6e-105	387.5	Gammaproteobacteria	yqeH			ko:K21907					ko00000,ko03000				Bacteria	1RFRZ@1224,1S57R@1236,COG2771@1,COG2771@2	NA|NA|NA	K	regulation of nucleic acid-templated transcription
C1_00294	155864.EDL933_4026	1.8e-218	765.0	Escherichia	yqeG	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0008150,GO:0015711,GO:0015804,GO:0015849,GO:0015893,GO:0016020,GO:0032329,GO:0042221,GO:0042493,GO:0042940,GO:0042942,GO:0044464,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944		ko:K03834,ko:K03835,ko:K03836,ko:K03837,ko:K03838					ko00000,ko02000	2.A.42.1.1,2.A.42.1.2,2.A.42.1.3,2.A.42.2.1,2.A.42.2.2		iAPECO1_1312.APECO1_3308,iE2348C_1286.E2348C_3406,iEC55989_1330.EC55989_3533,iEC55989_1330.EC55989_3581,iECABU_c1320.ECABU_c35330,iECED1_1282.ECED1_3781,iECIAI1_1343.ECIAI1_3265,iECNA114_1301.ECNA114_4343,iECO103_1326.ECO103_3863,iECO103_1326.ECO103_3910,iECO111_1330.ECO111_3985,iECO26_1355.ECO26_4221,iECO26_1355.ECO26_4267,iECOK1_1307.ECOK1_3543,iECP_1309.ECP_3209,iECSE_1348.ECSE_3400,iECSE_1348.ECSE_3447,iECSF_1327.ECSF_2956,iECUMN_1333.ECUMN_2202,iECW_1372.ECW_m3385,iEKO11_1354.EKO11_0601,iEcE24377_1341.EcE24377A_3643,iLF82_1304.LF82_2232,iNRG857_1313.NRG857_15495,iSBO_1134.SBO_2981,iSDY_1059.SDY_3013,iSFV_1184.SFV_3804,iSFxv_1172.SFxv_4080,iSSON_1240.SSON_3307,iS_1188.S4018,iSbBS512_1146.SbBS512_E3241,iUMN146_1321.UM146_00750,iUTI89_1310.UTI89_C3551,iWFL_1372.ECW_m3385,ic_1306.c3874	Bacteria	1QF5A@1224,1RR18@1236,3XM49@561,COG0814@1,COG0814@2	NA|NA|NA	E	Inner membrane transport protein YqeG
C1_00295	469008.B21_02655	2.1e-216	758.1	Escherichia	yqeF	GO:0003674,GO:0003824,GO:0003988,GO:0006066,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034308,GO:0034309,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044283,GO:0046165,GO:0046395,GO:0055114,GO:0071270,GO:0071271,GO:0071704,GO:0072329,GO:1901575,GO:1901576,GO:1901615,GO:1901617	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147			iAF1260.b2224,iB21_1397.B21_02110,iBWG_1329.BWG_1998,iECBD_1354.ECBD_1435,iECB_1328.ECB_02151,iECDH10B_1368.ECDH10B_2382,iECDH1ME8569_1439.ECDH1ME8569_2159,iECD_1391.ECD_02151,iETEC_1333.ETEC_2358,iEcDH1_1363.EcDH1_1434,iEcolC_1368.EcolC_1426,iJO1366.b2224,iJR904.b2224,iSSON_1240.SSON_3004,iY75_1357.Y75_RS11660	Bacteria	1MU5G@1224,1RM93@1236,3XMDN@561,COG0183@1,COG0183@2	NA|NA|NA	I	Belongs to the thiolase family
C1_00296	469008.B21_02654	5.2e-161	573.5	Escherichia	kduI	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005975,GO:0005996,GO:0006063,GO:0006064,GO:0006082,GO:0008150,GO:0008152,GO:0008697,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016853,GO:0016860,GO:0016861,GO:0019585,GO:0019586,GO:0019698,GO:0019752,GO:0032787,GO:0042802,GO:0042839,GO:0042840,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046365,GO:0046395,GO:0046396,GO:0046397,GO:0046872,GO:0071704,GO:0072329,GO:1901575	5.3.1.17	ko:K01815	ko00040,map00040		R04383	RC00541	ko00000,ko00001,ko01000				Bacteria	1MU9D@1224,1RPDB@1236,3XPE6@561,COG3717@1,COG3717@2	NA|NA|NA	G	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
C1_00297	362663.ECP_2855	5.1e-139	500.4	Escherichia													Bacteria	1MWB6@1224,1RMZB@1236,3XP6J@561,COG1028@1,COG1028@2	NA|NA|NA	IQ	Catalyzes the reversible reduction of 2,5-diketo-3- deoxygluconate (DKII or 4,6-dihydroxy-2,5-dioxohexanoate) into 2- keto-3-deoxygluconate (KDG or 2-dehydro-3-deoxygluconate) with a concomitant oxidation of NADH (Ref.4). To a lesser extent, can also reduce 5-keto-D-gluconate and oxidize D-gluconate and 1,2- propanediol. Together with KduI, seems to play a role in the catabolism of hexuronates under osmotic stress conditions, substituting for the regular hexuronate degrading enzymes UxaABC and UxuAB whose expression is repressed in these conditions. In vitro, also exhibits NADH- dependent 20-ketosteroid reductase activity against eukaryotic steroid hormone 11-deoxycorticosterone (11-DOC), which is converted into the product 4-pregnen-20,21-diol-3-one. In addition to 11-DOC, five other C21 steroid compounds (11-deoxycortisol, cortisol, corticosterone, cortisone, and 21-hydroxypregnenolone) are reduced by KduD, but steroids lacking the hydroxyl group at C21 position, such as pregnenolone, testosterone propionate, cortisone acetate, or progesterone, cannot be used as substrate
C1_00298	155864.EDL933_4022	3.2e-256	890.6	Escherichia	araE	GO:0003674,GO:0005215,GO:0005351,GO:0005402,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0008643,GO:0008645,GO:0015075,GO:0015077,GO:0015078,GO:0015144,GO:0015145,GO:0015146,GO:0015147,GO:0015149,GO:0015150,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015672,GO:0015749,GO:0015750,GO:0015751,GO:0015756,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034219,GO:0034220,GO:0042882,GO:0042900,GO:0044425,GO:0044459,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600		ko:K02100,ko:K08137,ko:K08138					ko00000,ko02000	2.A.1.1.1,2.A.1.1.2,2.A.1.1.3		iAF1260.b2841,iBWG_1329.BWG_2577,iEC55989_1330.EC55989_3118,iECDH10B_1368.ECDH10B_3013,iECDH1ME8569_1439.ECDH1ME8569_2748,iECDH1ME8569_1439.EcDH1_0849,iECIAI1_1343.ECIAI1_2951,iECIAI1_1343.ECIAI1_4259,iECIAI39_1322.ECIAI39_3261,iECO111_1330.ECO111_3570,iECO26_1355.ECO26_3914,iECSE_1348.ECSE_3098,iECSE_1348.ECSE_4322,iECUMN_1333.ECUMN_3169,iECW_1372.ECW_m3086,iECs_1301.ECs3698,iEKO11_1354.EKO11_0899,iETEC_1333.ETEC_3028,iEcDH1_1363.EcDH1_0849,iEcE24377_1341.EcE24377A_3162,iEcHS_1320.EcHS_A2988,iG2583_1286.G2583_3498,iG2583_1286.G2583_3602,iJO1366.b2841,iJR904.b2841,iSSON_1240.SSON_3001,iUMNK88_1353.UMNK88_3526,iWFL_1372.ECW_m3086,iY75_1357.Y75_RS14785,iZ_1308.Z4161	Bacteria	1MVKJ@1224,1RMHJ@1236,3XM9W@561,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
C1_00299	155864.EDL933_4021	6.2e-128	463.4	Escherichia	ygeA	GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0030203,GO:0034645,GO:0036361,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0047661,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	5.1.1.13	ko:K01779	ko00250,ko01054,map00250,map01054		R00491	RC00302	ko00000,ko00001,ko01000				Bacteria	1MV03@1224,1RMHT@1236,3XP1E@561,COG1794@1,COG1794@2	NA|NA|NA	M	Belongs to the aspartate glutamate racemases family
C1_00300	155864.EDL933_4020	9.9e-169	599.4	Escherichia	lysR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009893,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0016053,GO:0019222,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0048518,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607											Bacteria	1MX2A@1224,1RPHN@1236,3XMKM@561,COG0583@1,COG0583@2	NA|NA|NA	K	Transcriptional activator protein LysR
C1_00301	316407.85675654	2.4e-242	844.3	Escherichia	lysA	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008836,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.4,4.1.1.20	ko:K01586,ko:K12526	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00525,M00526,M00527	R00451,R00480	RC00002,RC00043,RC00299	ko00000,ko00001,ko00002,ko01000			iG2583_1286.G2583_3495	Bacteria	1MUA6@1224,1RMI2@1236,3XNIT@561,COG0019@1,COG0019@2	NA|NA|NA	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
C1_00302	34506.g5045	7.2e-189	666.4	Eukaryota													Eukaryota	2D24H@1,2SKEM@2759	NA|NA|NA	S	Periplasmic binding protein-like domain
C1_00303	34506.g5046	0.0	1432.9	Bilateria												iEC042_1314.EC042_3034	Metazoa	3AH4C@33154,3BWRG@33208,3DECZ@33213,COG0318@1,KOG1176@2759	NA|NA|NA	I	Acyltransferase
C1_00304	316407.85675651	8.3e-213	746.1	Escherichia	lplT	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0019637,GO:0031224,GO:0031226,GO:0044237,GO:0044238,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0046486,GO:0071704,GO:0071944	2.3.1.40,6.2.1.20	ko:K05939,ko:K08227	ko00071,ko00564,map00071,map00564		R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000,ko02000	2.A.1.42		iEC042_1314.EC042_3033,iECIAI39_1322.ECIAI39_3255,iEcSMS35_1347.EcSMS35_2983	Bacteria	1QUAG@1224,1T1RI@1236,3XNIS@561,COG0477@1,COG0477@2	NA|NA|NA	EGP	Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell
C1_00305	198214.SF2844	6.6e-198	696.4	Gammaproteobacteria	tas	GO:0003674,GO:0003824,GO:0004033,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016491,GO:0016614,GO:0016616,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034198,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0071496,GO:1990928											Bacteria	1MV2Y@1224,1RNXH@1236,COG0667@1,COG0667@2	NA|NA|NA	C	Aldo keto reductase
C1_00306	1114922.CIFAM_10_03890	9e-33	145.6	Citrobacter	ygdR												Bacteria	1N7UN@1224,1SDGH@1236,2E9MC@1,333U0@2,3WYW3@544	NA|NA|NA	S	Bacterial protein of unknown function (DUF903)
C1_00307	155864.EDL933_4012	2.4e-119	434.9	Escherichia	ygdQ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1MWC9@1224,1T1GE@1236,3XPE9@561,COG0861@1,COG0861@2	NA|NA|NA	P	UPF0053 inner membrane protein YgdQ
C1_00308	155864.EDL933_4011	4.5e-126	457.2	Escherichia	mutH	GO:0000018,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009036,GO:0009987,GO:0015666,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0019219,GO:0019222,GO:0031323,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0043765,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1990391		ko:K03573	ko03430,map03430				ko00000,ko00001,ko03400				Bacteria	1MVYX@1224,1RQVV@1236,3XNN5@561,COG3066@1,COG3066@2	NA|NA|NA	L	Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair
C1_00309	469008.B21_04427	3.1e-21	106.7	Gammaproteobacteria													Bacteria	1NDCY@1224,1SFMD@1236,2E8MH@1,332YY@2	NA|NA|NA		
C1_00310	155864.EDL933_4009	1.6e-99	368.6	Escherichia	nudH	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010468,GO:0010604,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019219,GO:0019222,GO:0019439,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0033554,GO:0034353,GO:0034641,GO:0034655,GO:0043167,GO:0043169,GO:0043170,GO:0043487,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0045935,GO:0046483,GO:0046700,GO:0046872,GO:0048518,GO:0048519,GO:0048522,GO:0050779,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:1901360,GO:1901361,GO:1901575		ko:K08311	ko03018,map03018		R10816	RC00002	ko00000,ko00001,ko01000,ko03019				Bacteria	1RDGJ@1224,1S3PQ@1236,3XN4C@561,COG0494@1,COG0494@2	NA|NA|NA	L	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage
C1_00311	155864.EDL933_4008	0.0	1426.8	Escherichia	ptsP	GO:0003674,GO:0003824,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008965,GO:0009987,GO:0010033,GO:0010243,GO:0016310,GO:0016740,GO:0016772,GO:0016775,GO:0019538,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0071704,GO:1901564,GO:1901698	2.7.3.9	ko:K08483,ko:K08484	ko02060,map02060				ko00000,ko00001,ko01000,ko02000	8.A.7			Bacteria	1QTTV@1224,1T1H2@1236,3XPFC@561,COG3605@1,COG3605@2	NA|NA|NA	T	Component of the phosphoenolpyruvate-dependent nitrogen- metabolic phosphotransferase system (nitrogen-metabolic PTS), that seems to be involved in regulating nitrogen metabolism. Enzyme I- Ntr transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (NPr). Could function in the transcriptional regulation of sigma-54 dependent operons in conjunction with the NPr (PtsO) and EIIA-Ntr (PtsN) proteins. Enzyme I-Ntr is specific for NPr
C1_00312	155864.EDL933_4007	1.9e-169	601.7	Escherichia	lgt	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008961,GO:0009058,GO:0009059,GO:0009249,GO:0009898,GO:0009987,GO:0010467,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0040007,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0051604,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:0140096,GO:1901564,GO:1901566,GO:1901576	2.1.1.199	ko:K03438,ko:K13292					ko00000,ko01000,ko03009				Bacteria	1MVE3@1224,1RMVK@1236,3XN5H@561,COG0682@1,COG0682@2	NA|NA|NA	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C1_00313	1440052.EAKF1_ch3189	4.6e-159	567.0	Escherichia	thyA	GO:0000287,GO:0003674,GO:0003824,GO:0004799,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006231,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009157,GO:0009162,GO:0009165,GO:0009176,GO:0009177,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009314,GO:0009394,GO:0009628,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019438,GO:0019637,GO:0019692,GO:0032259,GO:0034641,GO:0034654,GO:0042083,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046073,GO:0046385,GO:0046483,GO:0046872,GO:0050896,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000			iAF1260.b2827,iAPECO1_1312.APECO1_3678,iBWG_1329.BWG_2562,iE2348C_1286.E2348C_3096,iEC042_1314.EC042_3024,iEC55989_1330.EC55989_3103,iECABU_c1320.ECABU_c31240,iECDH10B_1368.ECDH10B_2997,iECDH1ME8569_1439.ECDH1ME8569_2734,iECED1_1282.ECED1_3283,iECH74115_1262.ECH74115_4093,iECIAI1_1343.ECIAI1_2935,iECIAI39_1322.ECIAI39_3246,iECNA114_1301.ECNA114_2885,iECO103_1326.ECO103_3386,iECO111_1330.ECO111_3555,iECO26_1355.ECO26_3899,iECOK1_1307.ECOK1_3231,iECP_1309.ECP_2840,iECS88_1305.ECS88_3122,iECSE_1348.ECSE_3084,iECSF_1327.ECSF_2642,iECSP_1301.ECSP_3779,iECUMN_1333.ECUMN_3154,iECW_1372.ECW_m3069,iECs_1301.ECs3684,iEKO11_1354.EKO11_0914,iETEC_1333.ETEC_3014,iEcDH1_1363.EcDH1_0864,iEcE24377_1341.EcE24377A_3147,iEcSMS35_1347.EcSMS35_2974,iG2583_1286.G2583_3481,iJO1366.b2827,iJR904.b2827,iLF82_1304.LF82_2267,iNRG857_1313.NRG857_13965,iSSON_1240.SSON_2984,iUMN146_1321.UM146_02290,iUMNK88_1353.UMNK88_3511,iUTI89_1310.UTI89_C3229,iWFL_1372.ECW_m3069,iY75_1357.Y75_RS14705,iYL1228.KPN_03236,iZ_1308.Z4144,ic_1306.c3422	Bacteria	1MUBD@1224,1RPYV@1236,3XNAW@561,COG0207@1,COG0207@2	NA|NA|NA	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C1_00314	316407.85675642	1.5e-88	332.0	Escherichia	ppdA			ko:K02456,ko:K02457,ko:K02458,ko:K02679	ko03070,ko05111,map03070,map05111	M00331			ko00000,ko00001,ko00002,ko02044	3.A.15			Bacteria	1RDKI@1224,1S4ND@1236,3XN4R@561,COG2165@1,COG2165@2	NA|NA|NA	NU	Prokaryotic N-terminal methylation motif
C1_00315	469008.B21_02634	1.2e-100	372.5	Escherichia	ppdB			ko:K02459,ko:K02672,ko:K02680	ko03070,ko05111,map03070,map05111	M00331			ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15			Bacteria	1RHSZ@1224,1S374@1236,3XN7W@561,COG4795@1,COG4795@2	NA|NA|NA	U	Prepilin peptidase dependent protein B
C1_00316	469008.B21_02633	8e-67	259.6	Escherichia	ygdB												Bacteria	1MY9J@1224,1S83V@1236,2E4K6@1,32R55@2,3XPRP@561	NA|NA|NA	S	Protein of unknown function (DUF2509)
C1_00317	316407.85675639	6.4e-51	206.5	Escherichia	ppdC			ko:K02458,ko:K02671,ko:K02681	ko03070,ko05111,map03070,map05111	M00331			ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15			Bacteria	1N1S1@1224,1S9AD@1236,3XPX3@561,COG4967@1,COG4967@2	NA|NA|NA	NU	Type II secretion prepilin peptidase dependent protein C
C1_00318	316407.85675638	0.0	2287.3	Escherichia	recC	GO:0000724,GO:0000725,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0004518,GO:0004519,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006952,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008854,GO:0009314,GO:0009338,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016887,GO:0016895,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044355,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0099046,GO:0140097,GO:1901360,GO:1902494	3.1.11.5	ko:K03583	ko03440,map03440				ko00000,ko00001,ko01000,ko03400				Bacteria	1MWTI@1224,1RNT0@1236,3XMIF@561,COG1330@1,COG1330@2	NA|NA|NA	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C1_00319	316407.85675637	0.0	1896.3	Escherichia	ptrA	GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0016787,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.24.55,3.4.24.56	ko:K01407,ko:K01408	ko05010,map05010				ko00000,ko00001,ko01000,ko01002				Bacteria	1QTVC@1224,1T1IG@1236,3XNBP@561,COG1025@1,COG1025@2	NA|NA|NA	O	Endopeptidase that degrades small peptides of less than 7 kDa, such as glucagon and insulin
C1_00320	198214.SF2831	0.0	2337.8	Gammaproteobacteria	recB	GO:0000166,GO:0000724,GO:0000725,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0004518,GO:0004519,GO:0004520,GO:0004527,GO:0004529,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006952,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0008854,GO:0009314,GO:0009338,GO:0009628,GO:0009987,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016887,GO:0016895,GO:0017076,GO:0017111,GO:0030554,GO:0032392,GO:0032508,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044355,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0099046,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494	3.1.11.5,3.6.4.12	ko:K03582,ko:K16898	ko03440,map03440				ko00000,ko00001,ko01000,ko03400				Bacteria	1MUTF@1224,1RPC6@1236,COG1074@1,COG1074@2	NA|NA|NA	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA
C1_00321	316407.85675635	0.0	1182.5	Escherichia	recD	GO:0000166,GO:0000724,GO:0000725,GO:0003674,GO:0003824,GO:0004386,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0008854,GO:0009338,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016887,GO:0016895,GO:0017076,GO:0017111,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043142,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494	3.1.11.5	ko:K03581	ko03440,map03440				ko00000,ko00001,ko01000,ko03400				Bacteria	1MW43@1224,1RPA0@1236,3XPFB@561,COG0507@1,COG0507@2	NA|NA|NA	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C1_00322	155864.EDL933_3996	1.5e-250	871.7	Escherichia	argA	GO:0003674,GO:0003824,GO:0003991,GO:0004042,GO:0004358,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016407,GO:0016410,GO:0016597,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,2.7.2.8	ko:K00619,ko:K00930,ko:K14682	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02649	RC00002,RC00004,RC00043,RC00064	ko00000,ko00001,ko00002,ko01000			iB21_1397.B21_03793,iEC55989_1330.EC55989_4441,iECB_1328.ECB_03844,iECDH10B_1368.ECDH10B_4147,iECDH1ME8569_1439.ECDH1ME8569_3827,iECD_1391.ECD_03844,iECH74115_1262.ECH74115_5419,iECIAI1_1343.ECIAI1_4167,iECO103_1326.ECO103_4715,iECOK1_1307.ECOK1_4431,iECP_1309.ECP_2830,iECS88_1305.ECS88_4414,iECSE_1348.ECSE_4252,iETEC_1333.ETEC_4227,iEcE24377_1341.EcE24377A_4498,iEcHS_1320.EcHS_A4193,iEcolC_1368.EcolC_4057,iLF82_1304.LF82_0116,iNRG857_1313.NRG857_13920,iSbBS512_1146.SbBS512_E4445,iUMN146_1321.UM146_20050,iUMNK88_1353.UMNK88_4797,iY75_1357.Y75_RS17255,iYL1228.KPN_03226	Bacteria	1MUUP@1224,1RMV5@1236,3XMQ7@561,COG0548@1,COG0548@2,COG1246@1,COG1246@2	NA|NA|NA	E	Belongs to the acetyltransferase family. ArgA subfamily
C1_00323	155864.EDL933_3995	6.9e-226	789.6	Escherichia	amiC	GO:0000003,GO:0000910,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0007049,GO:0008150,GO:0008745,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0019954,GO:0022402,GO:0022414,GO:0030288,GO:0030313,GO:0031975,GO:0032505,GO:0042597,GO:0043093,GO:0044464,GO:0051301,GO:0061783	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036			iG2583_1286.G2583_4996,iPC815.YPO1023,iSDY_1059.SDY_3034,iYL1228.KPN_03225	Bacteria	1MUQK@1224,1RMP1@1236,3XNFF@561,COG0860@1,COG0860@2	NA|NA|NA	M	Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family
C1_00327	316407.85675632	2e-213	748.0	Escherichia	mltA	GO:0000270,GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008933,GO:0009056,GO:0009057,GO:0009253,GO:0009279,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016787,GO:0016798,GO:0019867,GO:0030203,GO:0030288,GO:0030312,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0042597,GO:0043170,GO:0044425,GO:0044459,GO:0044462,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575		ko:K08304					ko00000,ko01000,ko01011		GH102	iECABU_c1320.ECABU_c30840	Bacteria	1MXD4@1224,1RP7K@1236,3XMK4@561,COG2821@1,COG2821@2	NA|NA|NA	M	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
C1_00328	198214.SF2826	1.8e-147	528.5	Gammaproteobacteria	ygdL	GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016829,GO:0016835,GO:0016836,GO:0030955,GO:0031402,GO:0031420,GO:0034470,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0061503,GO:0061504,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.7.7.73,2.7.7.80	ko:K03148,ko:K21029,ko:K22132	ko00730,ko01100,ko04122,map00730,map01100,map04122		R07459	RC00043	ko00000,ko00001,ko01000,ko03016				Bacteria	1MWXR@1224,1RMT3@1236,COG1179@1,COG1179@2	NA|NA|NA	H	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1
C1_00329	155864.EDL933_3992	4.3e-74	283.9	Escherichia	csdE	GO:0003674,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0061504,GO:0071704,GO:0090304,GO:0097163,GO:0140104,GO:1901360	2.8.1.7,4.4.1.16	ko:K02426,ko:K07125,ko:K11717	ko00450,ko01100,map00450,map01100		R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000			iSBO_1134.SBO_1451,iSbBS512_1146.SbBS512_E1880	Bacteria	1REQB@1224,1S44J@1236,3XMXS@561,COG2166@1,COG2166@2	NA|NA|NA	S	Stimulates the cysteine desulfurase activity of CsdA. Contains a cysteine residue (Cys-61) that acts to accept sulfur liberated via the desulfurase activity of CsdA. May be able to transfer sulfur to TcdA CsdL. Seems to support the function of TcdA in the generation of cyclic threonylcarbamoyladenosine at position 37 (ct(6)A37) in tRNAs that read codons beginning with adenine. Does not appear to participate in Fe S biogenesis
C1_00330	316407.85675629	5.6e-225	786.6	Escherichia	csdA	GO:0000096,GO:0001887,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006464,GO:0006520,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009000,GO:0009987,GO:0016043,GO:0016226,GO:0016740,GO:0016782,GO:0016783,GO:0016829,GO:0016846,GO:0019538,GO:0019752,GO:0019842,GO:0022607,GO:0030170,GO:0031071,GO:0031162,GO:0031163,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043436,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0048037,GO:0050662,GO:0051186,GO:0070279,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564	2.8.1.7,4.4.1.16	ko:K01766,ko:K11717	ko00450,ko01100,map00450,map01100		R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000			iAF1260.b2810,iAPECO1_1312.APECO1_3722,iAPECO1_1312.APECO1_757,iB21_1397.B21_02622,iBWG_1329.BWG_2548,iEC55989_1330.EC55989_1847,iEC55989_1330.EC55989_3089,iECBD_1354.ECBD_0912,iECB_1328.ECB_02661,iECDH10B_1368.ECDH10B_2980,iECDH1ME8569_1439.ECDH1ME8569_2720,iECD_1391.ECD_02661,iECED1_1282.ECED1_1879,iECO111_1330.ECO111_2149,iECO26_1355.ECO26_2408,iECOK1_1307.ECOK1_1800,iECS88_1305.ECS88_1730,iECS88_1305.ECS88_3079,iECW_1372.ECW_m1847,iEKO11_1354.EKO11_2095,iETEC_1333.ETEC_3000,iEcDH1_1363.EcDH1_0878,iEcolC_1368.EcolC_0902,iJO1366.b2810,iPC815.YPO1028,iUMN146_1321.UM146_08755,iUMNK88_1353.UMNK88_3495,iUTI89_1310.UTI89_C1872,iWFL_1372.ECW_m1847,iY75_1357.Y75_RS14620	Bacteria	1MUPD@1224,1RNIY@1236,3XPAM@561,COG0520@1,COG0520@2	NA|NA|NA	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine, and transiently retains the released sulfur atom on a cysteine residue, in the form of a persulfide. Can also desulfinate L-cysteine sulfinate, which is the best substrate of the enzyme. Functions as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate. Seems to participate in Fe S biogenesis by recruiting the SufBCD- SufE proteins. Transfers sulfur to CsdE that increases the cysteine desulfurase activity of CsdA. Can also transfer sulfur directly to TcdA CsdL in vitro. Appears to support the function of TcdA in the generation of cyclic threonylcarbamoyladenosine at position 37 (ct(6)A37) in tRNAs that read codons beginning with adenine
C1_00331	155864.EDL933_3990	1.4e-33	148.3	Escherichia	ygdI												Bacteria	1N053@1224,1S9DM@1236,2E9MC@1,32RSI@2,3XQ0I@561	NA|NA|NA	M	Bacterial protein of unknown function (DUF903)
C1_00332	155864.EDL933_3989	2.5e-169	601.3	Escherichia	gcvA	GO:0001130,GO:0001131,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141		ko:K03566	ko02026,map02026				ko00000,ko00001,ko03000				Bacteria	1MWY0@1224,1RP7Q@1236,3XP9I@561,COG0583@1,COG0583@2	NA|NA|NA	K	Regulatory protein for the glycine cleavage system operon (gcv). Mediates activation of gcv by glycine and repression by purines. GcvA is negatively autoregulated. Binds to three sites upstream of the gcv promoter
C1_00333	1440052.EAKF1_ch3206	1.5e-65	255.4	Escherichia	ygdD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1MZX3@1224,1SCNB@1236,3XPMP@561,COG2363@1,COG2363@2	NA|NA|NA	S	UPF0382 inner membrane protein YgdD
C1_00334	155864.EDL933_3987	1.4e-219	768.5	Escherichia	rlmM	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.186	ko:K06968					ko00000,ko01000,ko03009				Bacteria	1MWBM@1224,1RMSB@1236,3XM5R@561,COG2933@1,COG2933@2	NA|NA|NA	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C1_00335	198214.SF2819	2e-132	478.4	Gammaproteobacteria	fucR	GO:0003674,GO:0003700,GO:0006109,GO:0006355,GO:0008150,GO:0009889,GO:0009894,GO:0010468,GO:0010556,GO:0010675,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031329,GO:0043468,GO:0043470,GO:0043471,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0062012,GO:0065007,GO:0080090,GO:0098531,GO:0140110,GO:1903506,GO:2000112,GO:2001141		ko:K02430,ko:K02444					ko00000,ko03000				Bacteria	1NVBP@1224,1RXX5@1236,COG1349@1,COG1349@2	NA|NA|NA	K	transcriptional regulator
C1_00336	155864.EDL933_3985	1.5e-71	275.4	Escherichia	fucU	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016853,GO:0016854,GO:0016857,GO:0030246,GO:0036094,GO:0042806,GO:0044424,GO:0044464,GO:0048029	5.1.3.29	ko:K02431			R10764	RC00563	ko00000,ko01000				Bacteria	1RJ03@1224,1S27Q@1236,3XPKV@561,COG4154@1,COG4154@2	NA|NA|NA	G	Involved in the anomeric conversion of L-fucose
C1_00337	316407.85675622	1.2e-274	951.8	Escherichia	fucK	GO:0000166,GO:0003674,GO:0003824,GO:0004856,GO:0005488,GO:0005524,GO:0005975,GO:0005996,GO:0005997,GO:0005998,GO:0006004,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0008737,GO:0008744,GO:0008993,GO:0009056,GO:0009372,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0019200,GO:0019299,GO:0019301,GO:0019317,GO:0019318,GO:0019320,GO:0019321,GO:0019323,GO:0019324,GO:0019566,GO:0019568,GO:0019571,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042354,GO:0042355,GO:0042710,GO:0042732,GO:0042843,GO:0043167,GO:0043168,GO:0044010,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044764,GO:0046365,GO:0046372,GO:0046835,GO:0051704,GO:0071518,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901575	2.7.1.17,2.7.1.189,2.7.1.5,2.7.1.51,2.7.1.53	ko:K00848,ko:K00854,ko:K00879,ko:K00880,ko:K11216	ko00040,ko00051,ko00053,ko01100,ko01120,ko02024,map00040,map00051,map00053,map01100,map01120,map02024	M00014	R01639,R01901,R01902,R03014,R03241,R07127,R11183	RC00002,RC00017,RC00538	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_2885,iB21_1397.B21_02615,iECB_1328.ECB_02654,iECD_1391.ECD_02654,iECOK1_1307.ECOK1_4011,iECP_1309.ECP_3667,iECS88_1305.ECS88_3982,iECSF_1327.ECSF_2594,iEcE24377_1341.EcE24377A_4435,iEcSMS35_1347.EcSMS35_3903,iUMN146_1321.UM146_17990,iUTI89_1310.UTI89_C4105	Bacteria	1PT3G@1224,1RRVW@1236,3XQF4@561,COG1070@1,COG1070@2	NA|NA|NA	F	Catalyzes the phosphorylation of L-fuculose
C1_00338	198214.SF2816	0.0	1208.0	Gammaproteobacteria	fucI	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005996,GO:0006004,GO:0008150,GO:0008152,GO:0008736,GO:0008790,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019317,GO:0019318,GO:0019320,GO:0019321,GO:0019323,GO:0019566,GO:0019568,GO:0019571,GO:0042354,GO:0042355,GO:0042802,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046365,GO:0046372,GO:0071704,GO:1901575	5.3.1.25,5.3.1.3	ko:K01818	ko00051,ko01120,map00051,map01120		R03163	RC00434	ko00000,ko00001,ko01000			iECABU_c1320.ECABU_c30720,ic_1306.c3371	Bacteria	1MVD3@1224,1RYI3@1236,COG2407@1,COG2407@2	NA|NA|NA	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose
C1_00339	316407.85675620	8.5e-243	845.9	Escherichia	fucP	GO:0003674,GO:0005215,GO:0005351,GO:0005354,GO:0005402,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0008643,GO:0008645,GO:0009679,GO:0010035,GO:0015075,GO:0015077,GO:0015078,GO:0015144,GO:0015145,GO:0015146,GO:0015149,GO:0015150,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015517,GO:0015518,GO:0015535,GO:0015672,GO:0015749,GO:0015750,GO:0015751,GO:0015756,GO:0015757,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034219,GO:0034220,GO:0042221,GO:0042900,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0072714,GO:0098655,GO:0098660,GO:0098662,GO:1902600		ko:K02429,ko:K06141					ko00000,ko02000	2.A.1,2.A.1.7			Bacteria	1MXDC@1224,1RQX9@1236,3XMV3@561,COG0738@1,COG0738@2	NA|NA|NA	P	Mediates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Can also transport L-galactose and D-arabinose, but at reduced rates compared with L-fucose. Is not able to transport L-rhamnose and L-arabinose
C1_00340	198214.SF2814	1.3e-116	425.6	Gammaproteobacteria	fucA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006004,GO:0008150,GO:0008152,GO:0008270,GO:0008738,GO:0009056,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0019317,GO:0019318,GO:0019320,GO:0019321,GO:0019323,GO:0019566,GO:0019568,GO:0019571,GO:0042354,GO:0042355,GO:0043167,GO:0043169,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046372,GO:0046872,GO:0046914,GO:0071704,GO:1901575	4.1.2.17,5.1.3.4	ko:K01628,ko:K03077	ko00040,ko00051,ko00053,ko01100,ko01120,map00040,map00051,map00053,map01100,map01120	M00550	R02262,R05850	RC00603,RC00604,RC01479	ko00000,ko00001,ko00002,ko01000			iSDY_1059.SDY_4367,iSFV_1184.SFV_3593,iSSON_1240.SSON_0067	Bacteria	1MW7B@1224,1RPIK@1236,COG0235@1,COG0235@2	NA|NA|NA	G	Catalyzes the cleavage of L-fuculose 1-phosphate to glycerone phosphate and L-lactaldehyde
C1_00341	155864.EDL933_3980	5.9e-216	756.5	Escherichia	fucO	GO:0003674,GO:0003824,GO:0004022,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006004,GO:0006066,GO:0008150,GO:0008152,GO:0008198,GO:0008912,GO:0009056,GO:0016052,GO:0016491,GO:0016614,GO:0016616,GO:0019299,GO:0019301,GO:0019317,GO:0019318,GO:0019320,GO:0019751,GO:0034311,GO:0034313,GO:0042354,GO:0042355,GO:0042844,GO:0042846,GO:0043167,GO:0043169,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046164,GO:0046174,GO:0046365,GO:0046872,GO:0046914,GO:0051143,GO:0055114,GO:0071704,GO:1901575,GO:1901615,GO:1901616	1.1.1.1,1.1.1.77,1.1.99.37,1.2.98.1	ko:K00048,ko:K13954,ko:K17067	ko00010,ko00071,ko00350,ko00625,ko00626,ko00630,ko00640,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00010,map00071,map00350,map00625,map00626,map00630,map00640,map00680,map01100,map01110,map01120,map01130,map01200,map01220		R00614,R00623,R00754,R01781,R02257,R04880,R05233,R05234,R06917,R06927	RC00034,RC00050,RC00087,RC00088,RC00099,RC00116,RC00188,RC00649	ko00000,ko00001,ko01000			iAF1260.b2799,iECDH1ME8569_1439.ECDH1ME8569_2709,iECSE_1348.ECSE_3059,iECW_1372.ECW_m3009,iEKO11_1354.EKO11_0969,iEcDH1_1363.EcDH1_0889,iEcE24377_1341.EcE24377A_3104,iEcHS_1320.EcHS_A2943,iJO1366.b2799,iJR904.b2799,iUMNK88_1353.UMNK88_3484,iWFL_1372.ECW_m3009,iY75_1357.Y75_RS14565	Bacteria	1MVPH@1224,1RMVU@1236,3XPI7@561,COG1454@1,COG1454@2	NA|NA|NA	C	glycol catabolic process
C1_00342	316407.85675617	1.4e-161	575.5	Escherichia	xni	GO:0000287,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004519,GO:0004520,GO:0004527,GO:0004536,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006284,GO:0006308,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0017108,GO:0018130,GO:0019438,GO:0019439,GO:0022616,GO:0030955,GO:0031420,GO:0033554,GO:0033567,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0046872,GO:0048256,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901575,GO:1901576	2.7.7.7	ko:K01146,ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440		R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400				Bacteria	1MX9Y@1224,1RQZE@1236,3XNBW@561,COG0258@1,COG0258@2	NA|NA|NA	L	activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment
C1_00343	469008.B21_02604	8.8e-259	899.0	Escherichia	sdaB	GO:0003674,GO:0003824,GO:0003941,GO:0006082,GO:0006520,GO:0006563,GO:0006565,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016829,GO:0016840,GO:0016841,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	4.3.1.17	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230		R00220,R00590	RC00331,RC02600	ko00000,ko00001,ko01000			iECSP_1301.ECSP_4084,iECUMN_1333.ECUMN_2106	Bacteria	1MUZN@1224,1RMJZ@1236,3XNJ4@561,COG1760@1,COG1760@2	NA|NA|NA	E	L-serine dehydratase
C1_00344	155864.EDL933_3977	1.6e-230	805.1	Escherichia	sdaC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0008150,GO:0015711,GO:0015804,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032329,GO:0042221,GO:0042493,GO:0042940,GO:0042942,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944		ko:K03834,ko:K03835,ko:K03836,ko:K03837,ko:K03838					ko00000,ko02000	2.A.42.1.1,2.A.42.1.2,2.A.42.1.3,2.A.42.2.1,2.A.42.2.2		iAPECO1_1312.APECO1_3308,iAPECO1_1312.APECO1_3735,iE2348C_1286.E2348C_3063,iE2348C_1286.E2348C_3406,iEC55989_1330.EC55989_3533,iEC55989_1330.EC55989_3581,iECABU_c1320.ECABU_c30650,iECABU_c1320.ECABU_c35330,iECED1_1282.ECED1_3249,iECED1_1282.ECED1_3781,iECIAI1_1343.ECIAI1_3265,iECNA114_1301.ECNA114_2835,iECNA114_1301.ECNA114_4343,iECO103_1326.ECO103_3863,iECO103_1326.ECO103_3910,iECO111_1330.ECO111_3985,iECO26_1355.ECO26_4221,iECO26_1355.ECO26_4267,iECOK1_1307.ECOK1_3172,iECOK1_1307.ECOK1_3543,iECP_1309.ECP_2778,iECP_1309.ECP_3209,iECS88_1305.ECS88_3065,iECSE_1348.ECSE_3400,iECSE_1348.ECSE_3447,iECSF_1327.ECSF_2587,iECSF_1327.ECSF_2956,iECUMN_1333.ECUMN_2202,iECW_1372.ECW_m3385,iEKO11_1354.EKO11_0601,iEcE24377_1341.EcE24377A_3643,iEcSMS35_1347.EcSMS35_2936,iLF82_1304.LF82_2096,iLF82_1304.LF82_2232,iNRG857_1313.NRG857_13695,iNRG857_1313.NRG857_15495,iPC815.YPO1321,iSBO_1134.SBO_2981,iSDY_1059.SDY_3013,iSFV_1184.SFV_3804,iSFxv_1172.SFxv_4080,iSSON_1240.SSON_3307,iS_1188.S4018,iSbBS512_1146.SbBS512_E3241,iUMN146_1321.UM146_00750,iUMN146_1321.UM146_02585,iUTI89_1310.UTI89_C3167,iUTI89_1310.UTI89_C3551,iWFL_1372.ECW_m3385,iYL1228.KPN_03139,ic_1306.c3364,ic_1306.c3874	Bacteria	1NQFA@1224,1RQ8Q@1236,3XMD0@561,COG0814@1,COG0814@2	NA|NA|NA	E	Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity
C1_00345	155864.EDL933_3976	7.2e-261	906.0	Escherichia	ygdH	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016787,GO:0016798,GO:0016799,GO:0044424,GO:0044444,GO:0044464,GO:0047405	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240		R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000				Bacteria	1MVQJ@1224,1RQHX@1236,3XN7C@561,COG1611@1,COG1611@2	NA|NA|NA	S	Catalyzes the hydrolysis of the N-glycosidic bond of diverse pyrimidine and purine nucleotide 5'-monophosphates, to form ribose 5-phosphate and the corresponding free base. Can use AMP, GMP, IMP, CMP, dTMP and UMP as substrates. Cannot catalyze the reverse reactions
C1_00346	469008.B21_02601	5.1e-164	583.6	Escherichia	queF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016651,GO:0016657,GO:0018130,GO:0019438,GO:0033739,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.7.1.13	ko:K06879,ko:K09457	ko00790,ko01100,map00790,map01100		R07605	RC01875	ko00000,ko00001,ko01000,ko03016			iSFV_1184.SFV_2663,iSF_1195.SF2807,iS_1188.S3002	Bacteria	1MW0M@1224,1RNXM@1236,3XM7E@561,COG0780@1,COG0780@2,COG2904@1,COG2904@2	NA|NA|NA	F	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C1_00347	199310.c3359	7.9e-102	376.3	Escherichia	syd	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0009898,GO:0016020,GO:0019897,GO:0019898,GO:0031234,GO:0043254,GO:0044087,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0065007,GO:0071944,GO:0098552,GO:0098562		ko:K15723					ko00000				Bacteria	1RAB3@1224,1S2N3@1236,28Q4G@1,2ZCMR@2,3XMHR@561	NA|NA|NA	S	Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function
C1_00348	155864.EDL933_3973	7.2e-58	229.6	Escherichia	yqcC	GO:0008150,GO:0009987,GO:0042710,GO:0044010,GO:0044764,GO:0051704	3.5.1.28,5.1.3.13,5.4.99.26	ko:K01790,ko:K03806,ko:K06175	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000,ko01011,ko03016				Bacteria	1N7AG@1224,1SCXJ@1236,3XPR2@561,COG3098@1,COG3098@2	NA|NA|NA	S	single-species biofilm formation
C1_00349	198214.SF2804	3.3e-149	534.3	Gammaproteobacteria	truC	GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.26	ko:K06175					ko00000,ko01000,ko03016				Bacteria	1N8GW@1224,1RMZ7@1236,COG0564@1,COG0564@2	NA|NA|NA	J	Pseudouridine synthase
C1_00350	155864.EDL933_3971	4.1e-80	303.9	Escherichia	yqcA	GO:0000166,GO:0003674,GO:0005488,GO:0010181,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K06205					ko00000				Bacteria	1N27T@1224,1S906@1236,3XPFI@561,COG0716@1,COG0716@2	NA|NA|NA	C	FMN binding
C1_00351	199310.c3353	1.5e-255	888.3	Escherichia	gudP	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0015711,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0044425,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944		ko:K03535,ko:K08194,ko:K12299					ko00000,ko02000	2.A.1.14.1,2.A.1.14.14,2.A.1.14.7		iECO103_1326.ECO103_4467,iSF_1195.SF3164,iSFxv_1172.SFxv_3474,iSSON_1240.SSON_2946,iS_1188.S3379,iYO844.BSU02480	Bacteria	1MVPS@1224,1RNMV@1236,3XP9P@561,COG2271@1,COG2271@2	NA|NA|NA	P	glucarate transporter
C1_00352	469008.B21_02595	5.3e-214	750.0	Escherichia	gudD	GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0044237,GO:0044248	4.2.1.40	ko:K01706,ko:K13918	ko00053,ko01100,map00053,map01100		R02752,R08056	RC00543	ko00000,ko00001,ko01000			iECIAI39_1322.ECIAI39_3210,iECO26_1355.ECO26_3857	Bacteria	1NAKW@1224,1RN9M@1236,3XMB0@561,COG4948@1,COG4948@2	NA|NA|NA	M	Does not seem to have an in-vivo activity on glucarate or idarate. Its real substrate is
C1_00353	155864.EDL933_3965	2.6e-263	914.1	Escherichia	gudD	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0008872,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0019392,GO:0019394,GO:0019577,GO:0019579,GO:0019752,GO:0042737,GO:0042836,GO:0042838,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0046872,GO:0071704,GO:1901575	4.2.1.40	ko:K01706,ko:K13918	ko00053,ko01100,map00053,map01100		R02752,R08056	RC00543	ko00000,ko00001,ko01000			iECIAI39_1322.ECIAI39_3210,iECO26_1355.ECO26_3857	Bacteria	1NAKW@1224,1RNE2@1236,3XPFN@561,COG4948@1,COG4948@2	NA|NA|NA	M	Catalyzes the dehydration of glucarate to 5-keto-4- deoxy-D-glucarate (5-kdGluc). Also acts on L-idarate
C1_00354	155864.EDL933_3964	0.0	1782.7	Escherichia	barA	GO:0000155,GO:0000160,GO:0000302,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009636,GO:0009927,GO:0009987,GO:0010033,GO:0010035,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0042221,GO:0042493,GO:0042542,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046677,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0070887,GO:0071310,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901700	2.7.13.3	ko:K03407,ko:K07647,ko:K07673,ko:K07674,ko:K07678,ko:K18143,ko:K20973,ko:K20974	ko01501,ko02020,ko02025,ko02026,ko02030,ko05111,map01501,map02020,map02025,map02026,map02030,map05111	M00455,M00471,M00472,M00475,M00506,M00649,M00655,M00820			ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022,ko02035				Bacteria	1NRP8@1224,1SKTW@1236,3XMAV@561,COG0642@1,COG2205@2,COG3437@1,COG3437@2,COG3850@1,COG3850@2,COG4999@1,COG4999@2	NA|NA|NA	T	PhoQ Sensor
C1_00355	481805.EcolC_0927	4.3e-247	860.1	Escherichia	rlmD	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0070041,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.190	ko:K03215					ko00000,ko01000,ko03009				Bacteria	1MV3A@1224,1RN1D@1236,3XNZV@561,COG2265@1,COG2265@2	NA|NA|NA	J	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA
C1_00356	155864.EDL933_3962	0.0	1493.0	Escherichia	relA	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657	2.7.6.5,3.1.7.2	ko:K00951,ko:K01139	ko00230,map00230		R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009			iSFV_1184.SFV_2673	Bacteria	1MU44@1224,1RN3H@1236,3XP61@561,COG0317@1,COG0317@2	NA|NA|NA	F	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C1_00357	155864.EDL933_3961	1.1e-39	168.7	Gammaproteobacteria	chpR	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0032991,GO:0042802,GO:0042803,GO:0043933,GO:0044085,GO:0044877,GO:0046983,GO:0051259,GO:0051291,GO:0065003,GO:0071840,GO:0097159,GO:0097351,GO:1901363		ko:K07172,ko:K18829,ko:K18842					ko00000,ko02048				Bacteria	1N9Z6@1224,1SDVP@1236,COG2336@1,COG2336@2	NA|NA|NA	K	Antitoxin component of a type II toxin-antitoxin (TA) system. Labile antitoxin that binds to the MazF endoribonuclease toxin and neutralizes its endoribonuclease activity. Is considered to be an 'addiction' molecule as the cell dies in its absence. Toxicity results when the levels of MazE decrease in the cell, leading to mRNA degradation. This effect can be rescued by expression of MazE, but after 6 hours in rich medium the overexpression of MazF leads to programmed cell death. Cell growth and viability are not affected when MazF and MazE are coexpressed. Both MazE and MazE-MazF bind to the promoter region of the mazE- mazF operon to inhibit their own transcription. There are 3 operators to which MazE binds. MazE has higher affinity for promoter DNA in the presence of MazF
C1_00358	155864.EDL933_3960	3.6e-57	227.3	Gammaproteobacteria	chpA	GO:0001558,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019222,GO:0019439,GO:0022607,GO:0030308,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0040008,GO:0042802,GO:0042803,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044877,GO:0045926,GO:0046483,GO:0046700,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051259,GO:0051291,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575		ko:K07171					ko00000,ko01000,ko02048				Bacteria	1MZJ8@1224,1S5J7@1236,COG2337@1,COG2337@2	NA|NA|NA	T	Transcriptional modulator of MazE toxin, MazF
C1_00359	155864.EDL933_3959	1.2e-143	515.8	Escherichia	mazG	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009267,GO:0009394,GO:0009605,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042594,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.6.1.66,3.6.1.9	ko:K02428,ko:K02499,ko:K04765	ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100		R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R01855,R02100,R02720,R03004,R03036,R03531,R11323	RC00002	ko00000,ko00001,ko01000,ko03036			iAF1260.b2781,iBWG_1329.BWG_2516,iE2348C_1286.E2348C_3048,iEC55989_1330.EC55989_3056,iECDH10B_1368.ECDH10B_2948,iECDH1ME8569_1439.ECDH1ME8569_2691,iECH74115_1262.ECH74115_4041,iECIAI1_1343.ECIAI1_2889,iECO103_1326.ECO103_3324,iECO111_1330.ECO111_3505,iECO26_1355.ECO26_3851,iECOK1_1307.ECOK1_3155,iECP_1309.ECP_2762,iECSE_1348.ECSE_3039,iECSP_1301.ECSP_3733,iECW_1372.ECW_m2990,iECs_1301.ECs3641,iEKO11_1354.EKO11_0987,iEcDH1_1363.EcDH1_0907,iEcE24377_1341.EcE24377A_3085,iEcHS_1320.EcHS_A2925,iEcolC_1368.EcolC_0931,iG2583_1286.G2583_3433,iJO1366.b2781,iJR904.b2781,iSBO_1134.SBO_2662,iSSON_1240.SSON_2938,iSbBS512_1146.SbBS512_E3092,iUMN146_1321.UM146_02665,iUMNK88_1353.UMNK88_3464,iUTI89_1310.UTI89_C3150,iWFL_1372.ECW_m2990,iY75_1357.Y75_RS14470,iZ_1308.Z4096	Bacteria	1MVKM@1224,1RNVU@1236,3XNQT@561,COG1694@1,COG3956@2	NA|NA|NA	F	mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp produced by RelA under amino acid starvation, thus protecting the cell from the toxicity of MazF. Reduction of (p)ppGpp can be achieved by direct degradation of (p)ppGpp or by degradation of NTPs, which are substrates for (p)ppGpp synthesis by RelA
C1_00360	155864.EDL933_3958	0.0	1089.7	Escherichia	pyrG	GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_1276,iECO103_1326.ECO103_3323,iNJ661.Rv1699,iPC815.YPO3377	Bacteria	1MUIT@1224,1RM92@1236,3XMET@561,COG0504@1,COG0504@2	NA|NA|NA	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
C1_00361	1440052.EAKF1_ch3230	2e-236	824.7	Escherichia	eno	GO:0000015,GO:0000287,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005856,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902494	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147			iPC815.YPO3376	Bacteria	1MU1N@1224,1RNQA@1236,3XNNK@561,COG0148@1,COG0148@2	NA|NA|NA	F	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
C1_00362	316407.85675597	1.5e-139	502.3	Escherichia	ygcG			ko:K06872					ko00000				Bacteria	1PB41@1224,1S9CT@1236,3XMZX@561,COG1512@1,COG1512@2	NA|NA|NA	S	TPM domain
C1_00364	1440052.EAKF1_ch3234	5.5e-129	466.8	Escherichia	queE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	1.97.1.4,4.3.99.3	ko:K04068,ko:K10026	ko00790,ko01100,map00790,map01100		R04710,R10002	RC02989	ko00000,ko00001,ko01000,ko03016				Bacteria	1MUJ2@1224,1RNQZ@1236,3XMSU@561,COG0602@1,COG0602@2	NA|NA|NA	F	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
C1_00366	316407.85675586	1.5e-67	261.9	Escherichia	queD	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0070497,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016			iECIAI39_1322.ECIAI39_2947,iUTI89_1310.UTI89_C3129,ic_1306.c3324	Bacteria	1RI4P@1224,1S3T6@1236,3XPM2@561,COG0720@1,COG0720@2	NA|NA|NA	F	Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde
C1_00367	469008.B21_02572	0.0	1176.4	Escherichia	cysJ	GO:0000166,GO:0003674,GO:0003824,GO:0004783,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006790,GO:0008150,GO:0008152,GO:0009337,GO:0009987,GO:0010181,GO:0016491,GO:0016645,GO:0016646,GO:0016651,GO:0016667,GO:0016668,GO:0032553,GO:0032991,GO:0036094,GO:0042602,GO:0043167,GO:0043168,GO:0044237,GO:0044424,GO:0044464,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0055114,GO:0070401,GO:0097159,GO:0097367,GO:1901265,GO:1901363	1.8.1.2	ko:K00380	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00858	RC00065	ko00000,ko00001,ko00002,ko01000			iECO26_1355.ECO26_3835,iECSE_1348.ECSE_3020,iECW_1372.ECW_m2972,iEKO11_1354.EKO11_1004,iEcE24377_1341.EcE24377A_3066,iEcolC_1368.EcolC_0948,iWFL_1372.ECW_m2972,iYO844.BSU33440	Bacteria	1QUAH@1224,1T1RJ@1236,3XM2T@561,COG0369@1,COG0369@2	NA|NA|NA	E	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C1_00368	155864.EDL933_3935	0.0	1159.8	Escherichia	cysI	GO:0003674,GO:0003824,GO:0004783,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006790,GO:0008150,GO:0008152,GO:0009337,GO:0009987,GO:0016002,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016673,GO:0019419,GO:0020037,GO:0032991,GO:0044237,GO:0044424,GO:0044464,GO:0046906,GO:0048037,GO:0050311,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0097159,GO:1901363	1.7.7.1,1.8.1.2,1.8.7.1	ko:K00366,ko:K00381,ko:K00392	ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120	M00176,M00531	R00790,R00858,R00859,R03600	RC00065,RC00176	ko00000,ko00001,ko00002,ko01000			iEC55989_1330.EC55989_3037,iECH74115_1262.ECH74115_4017,iECIAI1_1343.ECIAI1_2867,iECNA114_1301.ECNA114_2794,iECO103_1326.ECO103_3307,iECSE_1348.ECSE_3019,iECSF_1327.ECSF_2552,iECSP_1301.ECSP_3712,iECUMN_1333.ECUMN_3091,iECW_1372.ECW_m2971,iECs_1301.ECs3618,iEKO11_1354.EKO11_1005,iEcE24377_1341.EcE24377A_3065,iSFV_1184.SFV_2742,iSbBS512_1146.SbBS512_E3112,iWFL_1372.ECW_m2971,iZ_1308.Z4073	Bacteria	1MVVB@1224,1RMFH@1236,3XMSN@561,COG0155@1,COG0155@2	NA|NA|NA	H	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate
C1_00369	198214.SF2778	4.1e-138	497.3	Gammaproteobacteria	cysH	GO:0000103,GO:0003674,GO:0003824,GO:0004604,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016667,GO:0016671,GO:0019379,GO:0019419,GO:0044237,GO:0044424,GO:0044464,GO:0055114	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000			iE2348C_1286.E2348C_3025,iECABU_c1320.ECABU_c30290,iECNA114_1301.ECNA114_2793,iECO103_1326.ECO103_3306,iECP_1309.ECP_2736,iECSF_1327.ECSF_2551,iETEC_1333.ETEC_2955,iLF82_1304.LF82_0415,iNRG857_1313.NRG857_13505,iSDY_1059.SDY_2964,ic_1306.c3321	Bacteria	1MXUR@1224,1RNC5@1236,COG0175@1,COG0175@2	NA|NA|NA	EH	Reduction of activated sulfate into sulfite
C1_00370	693444.D782_0941	1.4e-16	91.3	Gammaproteobacteria	hokE	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716		ko:K18922					ko00000,ko02048				Bacteria	1NER2@1224,1SD5D@1236,2ECM3@1,336J3@2	NA|NA|NA	S	Hok/gef family
C1_00371	155864.EDL933_3933	0.0	1304.7	Escherichia	cas3	GO:0000014,GO:0000287,GO:0000737,GO:0000738,GO:0002252,GO:0002376,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0004518,GO:0004519,GO:0004520,GO:0004527,GO:0004529,GO:0004536,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0006950,GO:0006952,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0008296,GO:0008408,GO:0009056,GO:0009057,GO:0009605,GO:0009607,GO:0009615,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016887,GO:0016895,GO:0017111,GO:0019439,GO:0033677,GO:0033680,GO:0034641,GO:0034655,GO:0042623,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0046872,GO:0050896,GO:0051607,GO:0051704,GO:0051707,GO:0070035,GO:0071667,GO:0071704,GO:0090304,GO:0090305,GO:0097098,GO:0097159,GO:0097617,GO:0098542,GO:0140097,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575		ko:K07012,ko:K19123					ko00000,ko01000,ko02048				Bacteria	1MX99@1224,1RMM0@1236,3XQCA@561,COG1203@1,COG1203@2	NA|NA|NA	L	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Cas3 plus Cascade participate in CRISPR interference, the third stage of CRISPR immunity
C1_00372	198214.SF2776	6.6e-198	696.4	Gammaproteobacteria	iap	GO:0003674,GO:0003824,GO:0004177,GO:0005575,GO:0005623,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0036211,GO:0042597,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564		ko:K09612					ko00000,ko01000,ko01002				Bacteria	1P2WI@1224,1RRBM@1236,COG2234@1,COG2234@2	NA|NA|NA	N	Catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3
C1_00373	316407.85675573	1.2e-174	619.0	Escherichia	cysD	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004779,GO:0004781,GO:0006082,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0050896,GO:0070566,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.8.4.10,1.8.4.8,2.7.7.4	ko:K00390,ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R02021,R04929	RC00007,RC02809,RC02862,RC02889	ko00000,ko00001,ko00002,ko01000			iJN746.PP_1303,iUMNK88_1353.UMNK88_3428,iYL1228.KPN_03114	Bacteria	1MUCZ@1224,1RNAD@1236,3XNQR@561,COG0175@1,COG0175@2	NA|NA|NA	H	sulfate adenylyltransferase), subunit 2
C1_00374	316407.85675572	7.8e-266	922.5	Escherichia	cysN	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0004779,GO:0004781,GO:0005488,GO:0005525,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0070566,GO:0097159,GO:0097367,GO:1901265,GO:1901363	2.7.1.25,2.7.7.4	ko:K00955,ko:K00956	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000			iECO103_1326.ECO103_3293	Bacteria	1MUD9@1224,1RME4@1236,3XMW1@561,COG2895@1,COG2895@2	NA|NA|NA	H	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily
C1_00375	155864.EDL933_3921	3.3e-109	401.0	Escherichia	cysC	GO:0003674,GO:0003824,GO:0004020,GO:0005488,GO:0005515,GO:0006790,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0042802,GO:0044237	2.7.1.25	ko:K00860	ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120	M00176	R00509,R04928	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000			iAF1260.b2750,iB21_1397.B21_02565,iBWG_1329.BWG_2486,iEC042_1314.EC042_2944,iEC55989_1330.EC55989_3023,iECBD_1354.ECBD_0974,iECB_1328.ECB_02600,iECDH10B_1368.ECDH10B_2918,iECDH1ME8569_1439.ECDH1ME8569_2660,iECD_1391.ECD_02600,iECH74115_1262.ECH74115_4002,iECIAI1_1343.ECIAI1_2852,iECO111_1330.ECO111_3474,iECO26_1355.ECO26_3819,iECSE_1348.ECSE_3002,iECSP_1301.ECSP_3698,iECUMN_1333.ECUMN_3074,iECW_1372.ECW_m2956,iECs_1301.ECs3604,iEKO11_1354.EKO11_1019,iEcDH1_1363.EcDH1_0938,iEcE24377_1341.EcE24377A_3051,iEcHS_1320.EcHS_A2888,iEcSMS35_1347.EcSMS35_2876,iG2583_1286.G2583_3398,iJO1366.b2750,iJR904.b2750,iSBO_1134.SBO_2770,iSDY_1059.SDY_2949,iSFV_1184.SFV_2748,iSSON_1240.SSON_2898,iUMNK88_1353.UMNK88_3426,iWFL_1372.ECW_m2956,iY75_1357.Y75_RS14315,iZ_1308.Z4058	Bacteria	1MX0D@1224,1RNWT@1236,3XPBT@561,COG0529@1,COG0529@2	NA|NA|NA	F	Catalyzes the synthesis of activated sulfate
C1_00376	316407.85675570	2.9e-51	207.6	Escherichia	ygbE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1MZA3@1224,1S97Z@1236,2C1QX@1,32TB7@2,3XPZ4@561	NA|NA|NA	S	Protein of unknown function (DUF3561)
C1_00377	155864.EDL933_3918	8e-51	206.1	Escherichia	ftsB	GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0030428,GO:0032153,GO:0032505,GO:0042802,GO:0043093,GO:0044464,GO:0051301,GO:0071944		ko:K05589					ko00000,ko03036				Bacteria	1N7AA@1224,1SD8H@1236,3XPSF@561,COG2919@1,COG2919@2	NA|NA|NA	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C1_00378	316407.85675568	3e-133	481.1	Escherichia	ispD	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0050518,GO:0070567,GO:0071704,GO:1901576	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000			iAF1260.b2747,iBWG_1329.BWG_2483,iEC55989_1330.EC55989_3019,iECDH10B_1368.ECDH10B_2915,iECDH1ME8569_1439.ECDH1ME8569_2657,iECIAI1_1343.ECIAI1_2848,iECO103_1326.ECO103_3289,iECO111_1330.ECO111_3471,iECO26_1355.ECO26_3816,iECSE_1348.ECSE_2999,iECW_1372.ECW_m2953,iEKO11_1354.EKO11_1022,iEcDH1_1363.EcDH1_0941,iEcE24377_1341.EcE24377A_3048,iEcHS_1320.EcHS_A2885,iEcolC_1368.EcolC_0965,iJO1366.b2747,iJR904.b2747,iPC815.YPO3361,iSBO_1134.SBO_2773,iSDY_1059.SDY_2946,iSSON_1240.SSON_2895,iSbBS512_1146.SbBS512_E3127,iUMNK88_1353.UMNK88_3422,iWFL_1372.ECW_m2953,iY75_1357.Y75_RS14300	Bacteria	1MY3B@1224,1S21S@1236,3XMF5@561,COG1211@1,COG1211@2	NA|NA|NA	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)
C1_00379	1440052.EAKF1_ch3247	2.6e-85	321.2	Escherichia	ispF	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008270,GO:0008685,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016849,GO:0030145,GO:0042180,GO:0042181,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	2.1.1.228,2.7.7.60,4.6.1.12	ko:K00554,ko:K00991,ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R00597,R05633,R05637	RC00002,RC00003,RC00334,RC01440	ko00000,ko00001,ko00002,ko01000,ko03016			iPC815.YPO3360	Bacteria	1MVHA@1224,1S3RQ@1236,3XMDM@561,COG0245@1,COG0245@2	NA|NA|NA	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)
C1_00380	316407.85675566	4.6e-199	700.3	Escherichia	truD	GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.27	ko:K06176					ko00000,ko01000,ko03016				Bacteria	1MXHD@1224,1RPRF@1236,3XMIA@561,COG0585@1,COG0585@2	NA|NA|NA	J	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs
C1_00381	155864.EDL933_3914	3.1e-144	517.7	Escherichia	surE	GO:0003674,GO:0003824,GO:0004309,GO:0005488,GO:0005515,GO:0006139,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008254,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009125,GO:0009129,GO:0009131,GO:0009158,GO:0009161,GO:0009164,GO:0009166,GO:0009173,GO:0009175,GO:0009218,GO:0009222,GO:0009259,GO:0009261,GO:0009987,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030145,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042578,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046049,GO:0046050,GO:0046131,GO:0046133,GO:0046135,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110		R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000			iSFxv_1172.SFxv_3035	Bacteria	1MVHE@1224,1RN36@1236,3XMK0@561,COG0496@1,COG0496@2	NA|NA|NA	F	Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'- monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain- length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs
C1_00382	155864.EDL933_3913	1.2e-114	419.1	Escherichia	pcm	GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0030091,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564	2.1.1.77	ko:K00573					ko00000,ko01000				Bacteria	1MXQC@1224,1RMHZ@1236,3XPAE@561,COG2518@1,COG2518@2	NA|NA|NA	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C1_00383	199310.c3308	7.7e-184	649.8	Escherichia	nlpD	GO:0000920,GO:0001896,GO:0005575,GO:0005623,GO:0008150,GO:0008219,GO:0009279,GO:0009987,GO:0012501,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0043085,GO:0044093,GO:0044462,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071944		ko:K06194,ko:K12943					ko00000	1.A.34.1.2			Bacteria	1RD24@1224,1RR11@1236,3XP0U@561,COG1388@1,COG1388@2,COG4942@1,COG4942@2	NA|NA|NA	M	autolysis
C1_00384	1114922.CIFAM_10_04760	4.7e-177	627.1	Citrobacter	rpoS	GO:0000988,GO:0000990,GO:0001000,GO:0001121,GO:0001123,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141		ko:K03087	ko02026,ko05111,map02026,map05111				ko00000,ko00001,ko03021				Bacteria	1MUDI@1224,1RN8V@1236,3WW6X@544,COG0568@1,COG0568@2	NA|NA|NA	K	Sigma-70 factor, region 1.2
C1_00385	198214.SF2763	2.2e-64	251.5	Gammaproteobacteria	hosA			ko:K06075,ko:K22489					ko00000,ko03000				Bacteria	1NM8R@1224,1S42F@1236,COG1846@1,COG1846@2	NA|NA|NA	K	Transcriptional regulator
C1_00386	155864.EDL933_3908	7.7e-20	102.4	Escherichia	ubiX	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0044237,GO:0044249,GO:0051186,GO:0051188	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_4253,iE2348C_1286.E2348C_2451,iECED1_1282.ECED1_2775,iECNA114_1301.ECNA114_2401,iECOK1_1307.ECOK1_2544,iECP_1309.ECP_2350,iECS88_1305.ECS88_2458,iECSF_1327.ECSF_2187,iLF82_1304.LF82_2354,iNRG857_1313.NRG857_11705,iUMN146_1321.UM146_05255,iUTI89_1310.UTI89_C2595	Bacteria	1RA0P@1224,1RPN1@1236,3XQ8X@561,COG0163@1,COG0163@2	NA|NA|NA	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for phenolic acid decarboxylase C
C1_00387	198214.SF2762	3.7e-60	237.3	Gammaproteobacteria	ubiX	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0044237,GO:0044249,GO:0051186,GO:0051188	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_4253,iE2348C_1286.E2348C_2451,iECED1_1282.ECED1_2775,iECNA114_1301.ECNA114_2401,iECOK1_1307.ECOK1_2544,iECP_1309.ECP_2350,iECS88_1305.ECS88_2458,iECSF_1327.ECSF_2187,iLF82_1304.LF82_2354,iNRG857_1313.NRG857_11705,iUMN146_1321.UM146_05255,iUTI89_1310.UTI89_C2595	Bacteria	1RA0P@1224,1RPN1@1236,COG0163@1,COG0163@2	NA|NA|NA	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN
C1_00388	155864.EDL933_3907	3.6e-279	966.8	Escherichia	yclC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044464	4.1.1.61	ko:K01612	ko00627,ko01120,ko01220,map00627,map01120,map01220		R01238	RC00391	ko00000,ko00001,ko01000				Bacteria	1MU62@1224,1RRK9@1236,3XQFY@561,COG0043@1,COG0043@2	NA|NA|NA	H	Decarboxylase involved in the decarboxylation and detoxification of phenolic derivatives under both aerobic and anaerobic conditions. It is able to catalyze the reversible decarboxylation of 4-hydroxybenzoate and vanillate
C1_00389	155864.EDL933_3906	4.8e-40	169.9	Escherichia	bsdD		4.1.1.61	ko:K21759	ko00627,ko01120,ko01220,map00627,map01120,map01220		R01238	RC00391	ko00000,ko00001,ko01000				Bacteria	1MZBK@1224,1S9GY@1236,2CK9M@1,32SBW@2,3XR5P@561	NA|NA|NA	S	4-hydroxybenzoate decarboxylase
C1_00390	316407.85675561	1.2e-234	818.9	Escherichia	ygbN	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944		ko:K03299					ko00000,ko02000	2.A.8			Bacteria	1MUFG@1224,1RNGE@1236,3XNU2@561,COG2610@1,COG2610@2	NA|NA|NA	EG	gluconate transmembrane transporter activity
C1_00391	469008.B21_02554	2.1e-148	531.6	Escherichia	ygbM		5.3.1.22,5.3.1.35	ko:K01816,ko:K22131	ko00630,ko01100,map00630,map01100		R01394	RC00511	ko00000,ko00001,ko01000			iECO103_1326.ECO103_0481,iECO111_1330.ECO111_0541,iECO26_1355.ECO26_0541	Bacteria	1MV53@1224,1RQF9@1236,3XMPT@561,COG3622@1,COG3622@2	NA|NA|NA	G	isomerase activity
C1_00392	316407.85675559	4.6e-117	427.2	Escherichia	ygbL	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006004,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008738,GO:0008742,GO:0008994,GO:0009056,GO:0009058,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0016853,GO:0016854,GO:0016857,GO:0019299,GO:0019301,GO:0019317,GO:0019318,GO:0019320,GO:0019321,GO:0019323,GO:0019324,GO:0019566,GO:0019568,GO:0019569,GO:0019571,GO:0019572,GO:0019637,GO:0019752,GO:0019852,GO:0042354,GO:0042355,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046372,GO:0046373,GO:0046872,GO:0046914,GO:0051167,GO:0051186,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901159,GO:1901575,GO:1901576	4.1.1.104,4.1.2.17,4.1.2.19,5.1.3.4	ko:K01628,ko:K01629,ko:K03077,ko:K22130	ko00040,ko00051,ko00053,ko01100,ko01120,map00040,map00051,map00053,map01100,map01120	M00550	R01785,R02262,R02263,R05850	RC00438,RC00599,RC00603,RC00604,RC01479	ko00000,ko00001,ko00002,ko01000			iECED1_1282.ECED1_3191,iECO111_1330.ECO111_4403,iLF82_1304.LF82_1866,iNRG857_1313.NRG857_19475,iSDY_1059.SDY_4367,iSSON_1240.SSON_0067	Bacteria	1MW7B@1224,1RS8X@1236,3XPD2@561,COG0235@1,COG0235@2	NA|NA|NA	G	Belongs to the aldolase class II family. AraD FucA subfamily
C1_00393	362663.ECP_2715	1.3e-232	812.0	Escherichia	ygbK		2.7.1.217	ko:K21948			R11706,R11707		ko00000,ko01000				Bacteria	1MW4G@1224,1RN8I@1236,3XN2W@561,COG3395@1,COG3395@2	NA|NA|NA	S	kinase activity
C1_00394	469008.B21_02551	4.5e-158	563.9	Escherichia	ygbJ		1.1.1.411	ko:K08319					ko00000,ko01000				Bacteria	1MUD0@1224,1RQXA@1236,3XPGH@561,COG2084@1,COG2084@2	NA|NA|NA	I	Catalyzes oxidation of L-threonate to 2-oxo-tetronate. Can use either NAD( ) or NADP( ) as cosubstrate, with a preference for NAD( )
C1_00395	481805.EcolC_0977	9.3e-133	479.6	Escherichia	lacR	GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141		ko:K02081,ko:K02530,ko:K03436					ko00000,ko03000				Bacteria	1MUJG@1224,1RQW3@1236,3XP4G@561,COG1349@1,COG1349@2	NA|NA|NA	K	Transcriptional regulator
C1_00396	155864.EDL933_3905	4e-124	450.7	Escherichia	pphA	GO:0003674,GO:0003824,GO:0004721,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008138,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564	3.1.3.16	ko:K07313,ko:K07314					ko00000,ko01000				Bacteria	1RAJ3@1224,1S3E3@1236,3XPTG@561,COG0639@1,COG0639@2	NA|NA|NA	T	phosphatase 2
C1_00397	155864.EDL933_3904	0.0	1655.2	Escherichia	mutS	GO:0000018,GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0008301,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030554,GO:0030983,GO:0031323,GO:0032136,GO:0032300,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1990391		ko:K03555	ko03430,map03430				ko00000,ko00001,ko03400			iECW_1372.ECW_m2935,iWFL_1372.ECW_m2935	Bacteria	1MUGX@1224,1RNW3@1236,3XMSY@561,COG0249@1,COG0249@2	NA|NA|NA	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C1_00399	198214.SF2749	2.1e-63	248.1	Gammaproteobacteria	ygbA												Bacteria	1N8FZ@1224,1S42H@1236,2E4R1@1,32ZJK@2	NA|NA|NA	S	Nitrous oxide-stimulated promoter
C1_00400	155864.EDL933_3901	0.0	1352.8	Escherichia	fhlA	GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001150,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016043,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0022607,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035326,GO:0042802,GO:0043170,GO:0043254,GO:0043565,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2000144,GO:2001141		ko:K02584,ko:K12146,ko:K12266,ko:K15836	ko02020,ko05132,map02020,map05132				ko00000,ko00001,ko03000				Bacteria	1QTT3@1224,1T1G7@1236,3XN8S@561,COG3604@1,COG3604@2	NA|NA|NA	KT	Formate hydrogen-lyase transcriptional activator
C1_00401	362663.ECP_2693	8.7e-187	659.4	Escherichia	hypE	GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0018193,GO:0018198,GO:0018249,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046892,GO:0051604,GO:0071704,GO:1901564		ko:K04655					ko00000				Bacteria	1MVCC@1224,1RQBE@1236,3XMMN@561,COG0309@1,COG0309@2	NA|NA|NA	O	formation protein hypE
C1_00402	198214.SF2746	9.2e-222	775.8	Gammaproteobacteria	hypD	GO:0003674,GO:0005488,GO:0005506,GO:0006464,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0019538,GO:0036211,GO:0042165,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046914,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0051604,GO:0070025,GO:0071704,GO:1901564		ko:K04654					ko00000				Bacteria	1MU1F@1224,1RRTQ@1236,COG0409@1,COG0409@2	NA|NA|NA	O	Belongs to the HypD family
C1_00403	155864.EDL933_3898	1.5e-45	188.3	Escherichia	hypC	GO:0003674,GO:0005488,GO:0005506,GO:0005515,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0010467,GO:0019538,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0046914,GO:0051604,GO:0071704,GO:1901564,GO:1902670		ko:K04653					ko00000				Bacteria	1RGXH@1224,1S96I@1236,3XPUT@561,COG0298@1,COG0298@2	NA|NA|NA	O	Is required for the formation of all three hydrogenase isoenzymes. May bind to the precursor form of the large subunit of dehydrogenases to keep them in a conformation accessible for metal incorporation
C1_00404	199310.c3287	1.5e-166	592.0	Escherichia	hypB	GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0010467,GO:0016151,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:1901564		ko:K04652					ko00000,ko03110				Bacteria	1MVBD@1224,1RN9Y@1236,3XNGB@561,COG0378@1,COG0378@2	NA|NA|NA	KO	Required for the maturation of the three NiFe hydrogenases. Exhibits a low intrinsic GTPase activity. The GTP hydrolysis catalyzed by HypB is an integral process in the incorporation of nickel into hydrogenases
C1_00405	155864.EDL933_3896	3.9e-62	243.8	Escherichia	hypA	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009898,GO:0010467,GO:0016020,GO:0016151,GO:0019538,GO:0019897,GO:0019898,GO:0031234,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0051604,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:1901564		ko:K04651					ko00000,ko03110				Bacteria	1MZJH@1224,1S5WG@1236,3XPNU@561,COG0375@1,COG0375@2	NA|NA|NA	S	Probably plays a role in a hydrogenase nickel cofactor insertion step
C1_00406	155864.EDL933_3894	3.1e-83	314.3	Escherichia	hycA			ko:K15833					ko00000				Bacteria	1RD07@1224,1S49S@1236,2C05Z@1,305VH@2,3XNMX@561	NA|NA|NA	K	Regulatory protein for the formate hydrogenlyase system. Could act by directly interacting with FhlA or by preventing the binding of FhlA to the upstream activatory sequence
C1_00407	155864.EDL933_3893	8e-111	406.4	Escherichia	hycB			ko:K05796,ko:K12136,ko:K15827					ko00000,ko01000			iAF1260.b2724,iBWG_1329.BWG_2460,iE2348C_1286.E2348C_2989,iEC042_1314.EC042_2918,iECABU_c1320.ECABU_c29950,iECDH10B_1368.ECDH10B_2892,iECDH1ME8569_1439.ECDH1ME8569_2634,iECED1_1282.ECED1_3175,iECO111_1330.ECO111_3444,iECO26_1355.ECO26_3789,iECP_1309.ECP_2687,iECUMN_1333.ECUMN_3046,iETEC_1333.ETEC_2915,iEcDH1_1363.EcDH1_0965,iEcHS_1320.EcHS_A2860,iEcSMS35_1347.EcSMS35_2849,iEcolC_1368.EcolC_0988,iJO1366.b2724,iJR904.b2724,iSFV_1184.SFV_2779,iSSON_1240.SSON_2871,iUMNK88_1353.UMNK88_3397,iY75_1357.Y75_RS14175,ic_1306.c3284	Bacteria	1MUHW@1224,1RQWU@1236,3XP6T@561,COG1142@1,COG1142@2	NA|NA|NA	C	electron transfer protein for hydrogenase
C1_00408	362663.ECP_2686	0.0	1150.2	Escherichia	hycC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K12137,ko:K15828					ko00000,ko01000			iB21_1397.B21_02538,iECBD_1354.ECBD_1002,iECB_1328.ECB_02573,iECD_1391.ECD_02573,iECED1_1282.ECED1_3174,iECO111_1330.ECO111_3443,iECO26_1355.ECO26_3788,iECP_1309.ECP_2686,iEcHS_1320.EcHS_A2859,iLF82_1304.LF82_1065,iNRG857_1313.NRG857_13330	Bacteria	1MXRW@1224,1RM9Q@1236,3XMXV@561,COG0651@1,COG0651@2	NA|NA|NA	CP	Formate hydrogenlyase, subunit
C1_00409	316407.85675543	1.6e-163	582.0	Escherichia	hycD	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0033554,GO:0044464,GO:0050896,GO:0051716,GO:0071944		ko:K12138,ko:K15829					ko00000,ko01000			iSFV_1184.SFV_2781,iUMNK88_1353.UMNK88_3079,iYL1228.KPN_03059	Bacteria	1MXV5@1224,1RPCY@1236,3XNSF@561,COG0650@1,COG0650@2	NA|NA|NA	C	oxidoreductase activity
C1_00410	155864.EDL933_3890	0.0	1164.8	Escherichia	hycE	GO:0003674,GO:0005488,GO:0016151,GO:0043167,GO:0043169,GO:0046872,GO:0046914		ko:K12142,ko:K15830					ko00000,ko01000			iECED1_1282.ECED1_3172,iEcE24377_1341.EcE24377A_2769,iYL1228.KPN_03058	Bacteria	1QUBF@1224,1RSJ4@1236,3XNB6@561,COG3261@1,COG3261@2,COG3262@1,COG3262@2	NA|NA|NA	C	nickel cation binding
C1_00411	155864.EDL933_3889	1.4e-90	339.0	Escherichia	hycF			ko:K12143,ko:K15831					ko00000			iAPECO1_1312.APECO1_3805,iECABU_c1320.ECABU_c29910,iECED1_1282.ECED1_3171,iECOK1_1307.ECOK1_3094,iUMN146_1321.UM146_02980,iUTI89_1310.UTI89_C3083,ic_1306.c3280	Bacteria	1R9YT@1224,1RQB1@1236,3XMEE@561,COG1143@1,COG1143@2	NA|NA|NA	C	electron transfer protein for hydrogenase
C1_00412	155864.EDL933_3888	6.7e-147	526.6	Escherichia	hycG			ko:K12144,ko:K15832					ko00000,ko01000			iEC55989_1330.EC55989_2985,iECNA114_1301.ECNA114_2753,iECSF_1327.ECSF_2512,iECSP_1301.ECSP_3428,iECs_1301.ECs3351	Bacteria	1QUBE@1224,1RNUG@1236,3XMV7@561,COG3260@1,COG3260@2	NA|NA|NA	C	Formate hydrogenlyase
C1_00413	199310.c3278	1.1e-71	275.8	Escherichia	hycH			ko:K12145,ko:K15834					ko00000,ko01000				Bacteria	1RHQ7@1224,1S6TA@1236,2DBX5@1,2ZBMB@2,3XP4F@561	NA|NA|NA	E	formate hydrogenlyase maturation
C1_00414	155864.EDL933_3886	6.8e-86	323.2	Escherichia	hycI	GO:0003674,GO:0003824,GO:0004175,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0051604,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.23.51	ko:K00442,ko:K03605,ko:K08315	ko00680,ko01100,ko01120,map00680,map01100,map01120		R03025	RC02628	ko00000,ko00001,ko01000,ko01002				Bacteria	1R3V7@1224,1S0IE@1236,3XP3A@561,COG0680@1,COG0680@2	NA|NA|NA	C	Protease involved in the C-terminal processing of HycE, the large subunit of hydrogenase 3
C1_00415	199310.c3276	2.9e-123	448.0	Escherichia													Bacteria	1ND96@1224,1SED2@1236,2EE8J@1,33831@2,3XQIT@561	NA|NA|NA		
C1_00416	1440052.EAKF1_ch3285	3.9e-53	213.8	Escherichia	higB			ko:K19166					ko00000,ko01000,ko02048				Bacteria	1N1N1@1224,1S932@1236,3XRAB@561,COG4680@1,COG4680@2	NA|NA|NA	J	this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase. mRNA interferases play a role in bacterial persistence to antibiotics
C1_00417	362663.ECP_2678	1.5e-68	265.4	Gammaproteobacteria	ygjM			ko:K18831					ko00000,ko02048,ko03000				Bacteria	1RBYR@1224,1S260@1236,COG5499@1,COG5499@2	NA|NA|NA	K	transcriptional regulator
C1_00418	316407.85675537	1.8e-283	981.1	Escherichia	ascB	GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0008150,GO:0008152,GO:0008422,GO:0008706,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0015926,GO:0016052,GO:0016787,GO:0016798,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046352,GO:0071704,GO:1901135,GO:1901575,GO:1901657,GO:2000891,GO:2000892	3.2.1.86	ko:K01223	ko00010,ko00500,map00010,map00500		R00839,R05133,R05134	RC00049,RC00171,RC00714	ko00000,ko00001,ko01000		GT1	iSSON_1240.SSON_3054	Bacteria	1MWG6@1224,1RMM2@1236,3XNCY@561,COG2723@1,COG2723@2	NA|NA|NA	G	Catalyzes the hydrolysis of phosphorylated beta- glucosides into glucose-6-phosphate (G-6-P) and aglycone. It has a high affinity for phosphorylated aromatic beta-glucosides (p- nitrophenyl-beta-glucoside, phenyl beta-glucoside, arbutin and phosphorylated salicin), and a low affinity for phosphorylated beta-methyl-glucoside
C1_00419	316407.85675536	6.7e-257	892.9	Escherichia	ascF	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0006950,GO:0006974,GO:0008150,GO:0008643,GO:0008645,GO:0009401,GO:0009758,GO:0009987,GO:0015144,GO:0015749,GO:0015764,GO:0015766,GO:0015771,GO:0015772,GO:0016020,GO:0016021,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0033554,GO:0034219,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090564,GO:0090586,GO:0090588,GO:0090589,GO:1901264,GO:1904659	2.7.1.192,2.7.1.193,2.7.1.199,2.7.1.201,2.7.1.208	ko:K02749,ko:K02752,ko:K02753,ko:K02755,ko:K02756,ko:K02757,ko:K02778,ko:K02779,ko:K02790,ko:K02791,ko:K02802,ko:K02803,ko:K02804,ko:K02818,ko:K02819,ko:K11191,ko:K11192	ko00010,ko00500,ko00520,ko02060,ko05111,map00010,map00500,map00520,map02060,map05111	M00265,M00266,M00267,M00268,M00270,M00271,M00272,M00303	R02738,R02780,R04111,R04394,R05132,R05199,R08559	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.1.1,4.A.1.1.10,4.A.1.1.15,4.A.1.1.16,4.A.1.1.2,4.A.1.1.3,4.A.1.1.4,4.A.1.1.5,4.A.1.1.7,4.A.1.1.8,4.A.1.2.11,4.A.1.2.13,4.A.1.2.2,4.A.1.2.3,4.A.1.2.4,4.A.1.2.5,4.A.1.2.6,4.A.1.2.7,4.A.1.2.8		iAPECO1_1312.APECO1_3811,iECABU_c1320.ECABU_c48060,iECIAI39_1322.ECIAI39_2574,iECIAI39_1322.ECIAI39_2901,iECNA114_1301.ECNA114_1668,iECOK1_1307.ECOK1_3087,iECP_1309.ECP_0691,iECS88_1305.ECS88_2978,iECSF_1327.ECSF_1482,iEcHS_1320.EcHS_A3936,iUMN146_1321.UM146_03015,iUTI89_1310.UTI89_C3077,ic_1306.c5339	Bacteria	1MXEG@1224,1RNEG@1236,3XP49@561,COG1263@1,COG1263@2,COG1264@1,COG1264@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in arbutin, cellobiose, and salicin transport
C1_00420	316407.85675535	2.6e-183	647.9	Escherichia	ascG	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K02529,ko:K03487					ko00000,ko03000				Bacteria	1N4ND@1224,1RNR5@1236,3XMZV@561,COG1609@1,COG1609@2	NA|NA|NA	K	Repressor of the asc operon. The cryptic operon is activated by the insertion of IS186 into the ascG gene
C1_00421	155864.EDL933_3881	2.7e-99	367.9	Escherichia	hydN	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0044237,GO:0044424,GO:0044464,GO:0055114		ko:K05796,ko:K12136,ko:K15827					ko00000,ko01000			iSSON_1240.SSON_2871	Bacteria	1PENN@1224,1RS57@1236,3XNQ6@561,COG1142@1,COG1142@2	NA|NA|NA	C	electron transport from formate to hydrogen
C1_00422	316407.85675533	0.0	1450.6	Escherichia	hypF	GO:0003674,GO:0003824,GO:0005488,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0010467,GO:0016740,GO:0016741,GO:0016743,GO:0019538,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046914,GO:0046944,GO:0051604,GO:0071704,GO:1901564		ko:K04656					ko00000			iAF987.Gmet_0119	Bacteria	1MVP8@1224,1RP08@1236,3XM8R@561,COG0068@1,COG0068@2	NA|NA|NA	O	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C1_00423	469008.B21_02526	1.3e-207	728.8	Escherichia	norW	GO:0000166,GO:0000302,GO:0001505,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0010035,GO:0015044,GO:0016491,GO:0016730,GO:0016731,GO:0017144,GO:0033554,GO:0034599,GO:0034614,GO:0034641,GO:0035690,GO:0036094,GO:0042133,GO:0042135,GO:0042221,GO:0042493,GO:0042737,GO:0043167,GO:0043168,GO:0044237,GO:0044248,GO:0044270,GO:0044424,GO:0044464,GO:0046209,GO:0046210,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071241,GO:0071731,GO:0071732,GO:0072593,GO:0097159,GO:0097366,GO:1901265,GO:1901363,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:2001057	1.18.1.3,1.7.1.15	ko:K00362,ko:K00529,ko:K12265	ko00071,ko00360,ko00910,ko01120,ko01220,ko05132,map00071,map00360,map00910,map01120,map01220,map05132	M00530,M00545	R00787,R02000,R06782,R06783	RC00098,RC00176	br01602,ko00000,ko00001,ko00002,ko01000			iEcHS_1320.EcHS_A2847,iSFxv_1172.SFxv_2845,iSSON_1240.SSON_2855	Bacteria	1NR3M@1224,1RQ07@1236,3XPFH@561,COG0446@1,COG0446@2	NA|NA|NA	C	One of at least two accessory proteins for anaerobic nitric oxide (NO) reductase. Reduces the rubredoxin moiety of NO reductase
C1_00424	198214.SF2733	1.1e-286	991.9	Gammaproteobacteria	norV	GO:0000166,GO:0000302,GO:0001505,GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006091,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009987,GO:0010035,GO:0010181,GO:0016043,GO:0016491,GO:0016661,GO:0017144,GO:0022607,GO:0022900,GO:0032553,GO:0034641,GO:0036094,GO:0042133,GO:0042135,GO:0042221,GO:0042493,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044248,GO:0044270,GO:0044424,GO:0044464,GO:0046209,GO:0046210,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0065007,GO:0065008,GO:0071731,GO:0071840,GO:0072593,GO:0097159,GO:0097366,GO:0097367,GO:1901265,GO:1901363,GO:1901698,GO:1901700,GO:2001057	1.6.3.4	ko:K03618,ko:K12264,ko:K22405	ko05132,map05132				ko00000,ko00001,ko01000			iE2348C_1286.E2348C_2967,iECED1_1282.ECED1_3159	Bacteria	1N731@1224,1SC8Q@1236,COG0426@1,COG0426@2,COG1773@1,COG1773@2	NA|NA|NA	C	uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center
C1_00425	481805.EcolC_1003	5.1e-284	983.0	Escherichia	norR	GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001130,GO:0001150,GO:0001151,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005506,GO:0005515,GO:0006355,GO:0008150,GO:0008198,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0035326,GO:0042802,GO:0043167,GO:0043169,GO:0043254,GO:0043565,GO:0044087,GO:0044089,GO:0044212,GO:0045893,GO:0045935,GO:0046872,GO:0046914,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070026,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2000144,GO:2001141		ko:K02584,ko:K12146,ko:K12266,ko:K15836	ko02020,ko05132,map02020,map05132				ko00000,ko00001,ko03000				Bacteria	1QTT3@1224,1T1G7@1236,3XMM3@561,COG3604@1,COG3604@2	NA|NA|NA	K	Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the norVW operon. Activation also requires sigma-54
C1_00426	481805.EcolC_1004	4.3e-175	620.5	Escherichia	gutQ	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0005996,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0019146,GO:0019294,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0046364,GO:0046394,GO:0046400,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	5.3.1.13	ko:K02467,ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005			iAPECO1_1312.APECO1_3818,iECABU_c1320.ECABU_c29780,iECED1_1282.ECED1_3157,iECH74115_1262.ECH74115_4519,iECOK1_1307.ECOK1_3081,iECS88_1305.ECS88_2971,iECSP_1301.ECSP_4172,iECs_1301.ECs4076,iSF_1195.SF2731,iS_1188.S2922,iUTI89_1310.UTI89_C3070,iZ_1308.Z4560,ic_1306.c3262	Bacteria	1MUXD@1224,1RMT9@1236,3XQB3@561,COG0517@1,COG0517@2,COG0794@1,COG0794@2	NA|NA|NA	F	It is also able of sustaining the biosynthetic pathway of 3-deoxy-D-manno-octulosonate (KDO), a unique 8-carbon sugar component of lipopolysaccharides (LPSs)
C1_00427	316407.85675528	5.1e-139	500.4	Escherichia	srlR	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K02081,ko:K02468					ko00000,ko03000				Bacteria	1MUJG@1224,1RNW4@1236,3XQVW@561,COG1349@1,COG1349@2	NA|NA|NA	K	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1_00428	316407.1800092	1.7e-60	238.4	Escherichia	gutM	GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141		ko:K02466					ko00000				Bacteria	1RIKE@1224,1S7CD@1236,3XQY2@561,COG4578@1,COG4578@2	NA|NA|NA	K	Glucitol operon activator
C1_00429	316407.1800091	7.2e-141	506.5	Escherichia													Bacteria	1MWSB@1224,1RNVJ@1236,3XQBG@561,COG1028@1,COG1028@2	NA|NA|NA	IQ	sorbitol catabolic process
C1_00430	155864.EDL933_3871	1.3e-63	248.8	Escherichia	srlB	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0009401,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0051179,GO:0051234,GO:0071702	2.7.1.198	ko:K02781	ko00051,ko02060,map00051,map02060	M00280	R05820	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.4.1		iB21_1397.B21_02519,iEC55989_1330.EC55989_2966,iECBD_1354.ECBD_1021,iECB_1328.ECB_02554,iECD_1391.ECD_02554,iECIAI39_1322.ECIAI39_2890,iECO111_1330.ECO111_3422,iECO26_1355.ECO26_3767,iECSE_1348.ECSE_2952,iECSP_1301.ECSP_3652,iECW_1372.ECW_m2903,iECs_1301.ECs3560,iEKO11_1354.EKO11_1071,iEcE24377_1341.EcE24377A_2988,iEcHS_1320.EcHS_A2840,iEcolC_1368.EcolC_1008,iG2583_1286.G2583_3352,iSSON_1240.SSON_2848,iWFL_1372.ECW_m2903,iZ_1308.Z4011	Bacteria	1RK6V@1224,1S6MU@1236,3XQY8@561,COG3731@1,COG3731@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II complex composed of SrlA, SrlB and SrlE is involved in glucitol sorbitol transport. It can also use D- mannitol
C1_00431	316407.85675526	1.2e-174	619.0	Gammaproteobacteria	srlE	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563	2.7.1.198	ko:K02782,ko:K02783	ko00051,ko02060,map00051,map02060	M00280	R05820	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.4.1		iEC55989_1330.EC55989_2965,iECIAI1_1343.ECIAI1_2795,iECO103_1326.ECO103_3238,iECO111_1330.ECO111_3421,iECSE_1348.ECSE_2951,iEcE24377_1341.EcE24377A_2987,iUMNK88_1353.UMNK88_3375	Bacteria	1QJR2@1224,1RQY1@1236,COG3732@1,COG3732@2	NA|NA|NA	G	PTS system glucitol sorbitol-specific
C1_00432	316407.85675525	5.6e-103	380.2	Gammaproteobacteria	srlA	GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0051179,GO:0051234,GO:0071702		ko:K02783	ko00051,ko02060,map00051,map02060	M00280	R05820	RC00017,RC03206	ko00000,ko00001,ko00002,ko02000	4.A.4.1		iSBO_1134.SBO_2816	Bacteria	1MXS5@1224,1RQTZ@1236,COG3730@1,COG3730@2	NA|NA|NA	G	PTS system glucitol sorbitol-specific
C1_00433	199310.c3255	2.7e-227	794.3	Escherichia	mltB	GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008932,GO:0008933,GO:0009056,GO:0009057,GO:0009253,GO:0009279,GO:0016020,GO:0016740,GO:0016757,GO:0019867,GO:0030203,GO:0030288,GO:0030312,GO:0030313,GO:0031402,GO:0031420,GO:0031975,GO:0042597,GO:0043167,GO:0043169,GO:0043170,GO:0044462,GO:0044464,GO:0046872,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575		ko:K08305					ko00000,ko01000,ko01011		GH103	iECABU_c1320.ECABU_c29710,iNRG857_1313.NRG857_13215	Bacteria	1MUZ3@1224,1RMQ6@1236,3XMG0@561,COG2951@1,COG2951@2	NA|NA|NA	M	Lytic murein transglycosylase B
C1_00434	199310.c3254	1.8e-84	318.5	Escherichia	ygaD	GO:0003674,GO:0003824,GO:0016787,GO:0016810,GO:0016811,GO:0019159	3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760		R02322	RC00100	ko00000,ko00001,ko01000				Bacteria	1RH2Y@1224,1S5WH@1236,3XMR0@561,COG1546@1,COG1546@2	NA|NA|NA	S	Belongs to the CinA family
C1_00435	155864.EDL933_3863	1.5e-194	685.3	Escherichia	recA	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006928,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0010212,GO:0031668,GO:0033554,GO:0034641,GO:0040011,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048870,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363		ko:K03553	ko03440,map03440	M00729			ko00000,ko00001,ko00002,ko03400				Bacteria	1MU3C@1224,1RMHP@1236,3XP8Q@561,COG0468@1,COG0468@2	NA|NA|NA	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C1_00436	155864.EDL933_3862	4.9e-90	337.0	Escherichia	recX	GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0019899,GO:0031668,GO:0033554,GO:0043086,GO:0044092,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496	2.4.1.337	ko:K03565,ko:K19002	ko00561,ko01100,map00561,map01100		R10850	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003,ko03400		GT4		Bacteria	1N6P6@1224,1SCMF@1236,3XMI0@561,COG2137@1,COG2137@2	NA|NA|NA	S	Modulates RecA activity through direct physical interaction. Can inhibit both RecA recombinase and coprotease activities. May have a regulatory role during the SOS response. Inhibits DNA strand exchange in vitro
C1_00437	198214.SF2720	0.0	1702.2	Gammaproteobacteria	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iECABU_c1320.ECABU_c29670,iECED1_1282.ECED1_3146,iEcHS_1320.EcHS_A2833,iJN746.PP_4474	Bacteria	1MU9A@1224,1RMWZ@1236,COG0013@1,COG0013@2	NA|NA|NA	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C1_00438	1005994.GTGU_02525	2.5e-23	114.0	Gammaproteobacteria	csrA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005979,GO:0006109,GO:0006139,GO:0006417,GO:0006446,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0010675,GO:0010677,GO:0010906,GO:0010962,GO:0016070,GO:0016071,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032881,GO:0032885,GO:0034248,GO:0034249,GO:0034641,GO:0043170,GO:0043255,GO:0043467,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045719,GO:0045912,GO:0045947,GO:0046483,GO:0048027,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0062012,GO:0065007,GO:0070873,GO:0070874,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:2000112,GO:2000113		ko:K03563	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111				ko00000,ko00001,ko03019				Bacteria	1N6PG@1224,1SCB4@1236,COG1551@1,COG1551@2	NA|NA|NA	J	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C1_00444	155864.EDL933_3857	1.1e-103	382.5	Escherichia	yqaB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008801,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016853,GO:0016866,GO:0016868,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872										iSF_1195.SF2717,iSFxv_1172.SFxv_2981,iS_1188.S2904	Bacteria	1PUMZ@1224,1RNJC@1236,3XP7X@561,COG0637@1,COG0637@2	NA|NA|NA	S	beta-phosphoglucomutase activity
C1_00445	198214.SF2716	5.1e-72	276.9	Gammaproteobacteria	yqaA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1RHUV@1224,1S69A@1236,COG1238@1,COG1238@2	NA|NA|NA	S	Membrane
C1_00446	199310.c3245	1.3e-303	1048.1	Escherichia	gshA	GO:0003674,GO:0003824,GO:0004357,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0008152,GO:0009058,GO:0009628,GO:0009987,GO:0010035,GO:0010038,GO:0016874,GO:0016879,GO:0016881,GO:0019184,GO:0034641,GO:0042221,GO:0042398,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0046685,GO:0046689,GO:0046872,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0070887,GO:0071241,GO:0071243,GO:0071248,GO:0071288,GO:0071704,GO:1901564,GO:1901566,GO:1901576	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000			iEC042_1314.EC042_2885	Bacteria	1MW9B@1224,1RPNQ@1236,3XNK6@561,COG2918@1,COG2918@2	NA|NA|NA	H	Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily
C1_00447	316407.1800072	1.1e-92	345.9	Escherichia	luxS	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0007154,GO:0007267,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009116,GO:0009119,GO:0009372,GO:0009987,GO:0010699,GO:0016053,GO:0016829,GO:0016846,GO:0017144,GO:0019284,GO:0019752,GO:0023052,GO:0033353,GO:0034641,GO:0042278,GO:0043094,GO:0043102,GO:0043436,GO:0043768,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0046128,GO:0046394,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0051704,GO:0055086,GO:0071265,GO:0071267,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901657	4.4.1.21	ko:K07173	ko00270,ko01100,ko01230,ko02024,ko02026,ko05111,map00270,map01100,map01230,map02024,map02026,map05111	M00609	R01291	RC00069,RC01929	ko00000,ko00001,ko00002,ko01000			iECIAI39_1322.ECIAI39_2877,iPC815.YPO3300	Bacteria	1MWQF@1224,1RMDZ@1236,3XN36@561,COG1854@1,COG1854@2	NA|NA|NA	F	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
C1_00448	155864.EDL933_3853	2.4e-289	1000.7	Escherichia	emrB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0009636,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0042221,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944		ko:K03446		M00701			ko00000,ko00002,ko02000	2.A.1.3			Bacteria	1MU1I@1224,1RNTG@1236,3XPHW@561,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
C1_00449	199310.c3238	1.1e-204	719.2	Escherichia	emrA	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0009897,GO:0009986,GO:0016020,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098552,GO:0098567		ko:K03543,ko:K07797	ko02020,map02020	M00701			ko00000,ko00001,ko00002,ko02000	8.A.1,8.A.1.1			Bacteria	1MU7I@1224,1RMAD@1236,3XP2J@561,COG1566@1,COG1566@2	NA|NA|NA	V	Multidrug resistance protein
C1_00450	155864.EDL933_3850	1.7e-93	348.6	Escherichia	mprA	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0046677,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K03712,ko:K15974		M00701			ko00000,ko00002,ko03000				Bacteria	1NWZ4@1224,1RPCJ@1236,3XP69@561,COG1846@1,COG1846@2	NA|NA|NA	K	Negative regulator of the multidrug operon emrAB
C1_00451	316407.1800068	2.7e-52	211.1	Escherichia	ygaH	GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015175,GO:0015179,GO:0015238,GO:0015318,GO:0015562,GO:0015658,GO:0015711,GO:0015803,GO:0015804,GO:0015807,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0022857,GO:0034220,GO:0042221,GO:0042493,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903785,GO:1903825,GO:1905039										iE2348C_1286.E2348C_2947,iECABU_c1320.ECABU_c29490,iECED1_1282.ECED1_3137,iECH74115_1262.ECH74115_3927,iECP_1309.ECP_2648,iECSF_1327.ECSF_2479,iECSP_1301.ECSP_3630,iECs_1301.ECs3545,iEcE24377_1341.EcE24377A_2966,iG2583_1286.G2583_3330,iLF82_1304.LF82_3128,iNRG857_1313.NRG857_13140,iSDY_1059.SDY_2878,iSFV_1184.SFV_2821,iSF_1195.SF2710,iSFxv_1172.SFxv_2973,iS_1188.S2897,ic_1306.c3236	Bacteria	1N2MP@1224,1S9C1@1236,2C11C@1,32WP6@2,3XPT9@561	NA|NA|NA	S	L-valine transmembrane transporter activity
C1_00452	199310.c3235	4.6e-129	467.2	Escherichia	ygaZ	GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015175,GO:0015179,GO:0015238,GO:0015318,GO:0015562,GO:0015658,GO:0015711,GO:0015803,GO:0015804,GO:0015807,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0022857,GO:0034220,GO:0042221,GO:0042493,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903785,GO:1903825,GO:1905039										iE2348C_1286.E2348C_2946,iEC042_1314.EC042_2879,iEC55989_1330.EC55989_2949,iECABU_c1320.ECABU_c29480,iECED1_1282.ECED1_3136,iECIAI1_1343.ECIAI1_2777,iECIAI39_1322.ECIAI39_2871,iECO111_1330.ECO111_3405,iECO26_1355.ECO26_3750,iECP_1309.ECP_2647,iECSE_1348.ECSE_2935,iECSF_1327.ECSF_2478,iECSP_1301.ECSP_3629,iECW_1372.ECW_m2878,iECs_1301.ECs3544,iEKO11_1354.EKO11_1090,iETEC_1333.ETEC_2878,iEcE24377_1341.EcE24377A_2965,iG2583_1286.G2583_3329,iLF82_1304.LF82_3135,iNRG857_1313.NRG857_13135,iSFV_1184.SFV_2822,iSSON_1240.SSON_2826,iWFL_1372.ECW_m2878,iZ_1308.Z3983,ic_1306.c3235	Bacteria	1P6U3@1224,1RRMC@1236,3XNS1@561,COG1296@1,COG1296@2	NA|NA|NA	E	L-valine transmembrane transporter activity
C1_00453	469008.B21_02500	1.1e-204	719.2	Escherichia	ygaY												Bacteria	1MVVW@1224,1RMXR@1236,3XNFB@561,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
C1_00454	469008.B21_02499	9.4e-194	682.6	Escherichia	proX	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0009628,GO:0015695,GO:0015696,GO:0015697,GO:0015838,GO:0030288,GO:0030313,GO:0031460,GO:0031975,GO:0042597,GO:0044464,GO:0050896,GO:0050997,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0072337		ko:K02001,ko:K02002	ko02010,map02010	M00208			ko00000,ko00001,ko00002,ko02000	3.A.1.12		iB21_1397.B21_02499,iEC55989_1330.EC55989_2947,iECBD_1354.ECBD_1040,iECB_1328.ECB_02535,iECD_1391.ECD_02535,iECO103_1326.ECO103_3220,iECO111_1330.ECO111_3403,iECO26_1355.ECO26_3748,iECW_1372.ECW_m2876,iEKO11_1354.EKO11_1092,iEcHS_1320.EcHS_A2815,iEcolC_1368.EcolC_1027,iUMNK88_1353.UMNK88_3348,iWFL_1372.ECW_m2876	Bacteria	1MWZU@1224,1RNDF@1236,3XP4T@561,COG2113@1,COG2113@2	NA|NA|NA	E	Part of the ProU ABC transporter complex involved in glycine betaine and proline betaine uptake. Binds glycine betaine and proline betaine with high affinity
C1_00455	155864.EDL933_3844	1.5e-189	668.7	Escherichia	proW	GO:0003674,GO:0005215,GO:0005275,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006836,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0009628,GO:0015695,GO:0015696,GO:0015697,GO:0015837,GO:0015838,GO:0015871,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0031460,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351		ko:K02001,ko:K02002	ko02010,map02010	M00208			ko00000,ko00001,ko00002,ko02000	3.A.1.12		iEcSMS35_1347.EcSMS35_2800	Bacteria	1MUM4@1224,1RPQS@1236,3XM5A@561,COG4176@1,COG4176@2	NA|NA|NA	P	glycine betaine
C1_00456	316407.1800065	6.4e-221	773.1	Escherichia	proV	GO:0000166,GO:0003674,GO:0004888,GO:0005034,GO:0005215,GO:0005275,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006950,GO:0006970,GO:0006972,GO:0007154,GO:0007165,GO:0008144,GO:0008150,GO:0009628,GO:0009987,GO:0015695,GO:0015696,GO:0015697,GO:0015837,GO:0015838,GO:0016020,GO:0016021,GO:0017076,GO:0022857,GO:0023052,GO:0030554,GO:0031224,GO:0031460,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0038023,GO:0043167,GO:0043168,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0060089,GO:0065007,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0097159,GO:0097367,GO:0098533,GO:0098796,GO:0098797,GO:1901265,GO:1901363,GO:1902494,GO:1902495,GO:1904949,GO:1990351	3.6.3.32	ko:K02000	ko02010,map02010	M00208			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.12		iAF1260.b2677,iB21_1397.B21_02497,iBWG_1329.BWG_2420,iEC042_1314.EC042_2875,iEC55989_1330.EC55989_2945,iECBD_1354.ECBD_1042,iECB_1328.ECB_02533,iECDH1ME8569_1439.ECDH1ME8569_2593,iECD_1391.ECD_02533,iECED1_1282.ECED1_3132,iECIAI1_1343.ECIAI1_2773,iECO103_1326.ECO103_3218,iECO111_1330.ECO111_3401,iECO26_1355.ECO26_3746,iECSE_1348.ECSE_2930,iECW_1372.ECW_m2874,iEKO11_1354.EKO11_1094,iETEC_1333.ETEC_2874,iEcDH1_1363.EcDH1_1006,iEcE24377_1341.EcE24377A_2958,iEcolC_1368.EcolC_1029,iG2583_1286.G2583_3325,iJO1366.b2677,iJR904.b2677,iPC815.YPO2647,iSBO_1134.SBO_2839,iSbBS512_1146.SbBS512_E3202,iUMNK88_1353.UMNK88_3346,iWFL_1372.ECW_m2874,iY75_1357.Y75_RS13940,iYL1228.KPN_03008	Bacteria	1MU86@1224,1RN2R@1236,3XMCF@561,COG4175@1,COG4175@2	NA|NA|NA	P	glycine, betaine
C1_00457	316407.1800064	2.1e-182	644.8	Escherichia	nrdF	GO:0003674,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0015949,GO:0018130,GO:0019438,GO:0019637,GO:0030145,GO:0032991,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0090304,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990204	1.17.4.1	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400			iAPECO1_1312.APECO1_4325,iECNA114_1301.ECNA114_2708,iECSF_1327.ECSF_2473,iSFV_1184.SFV_2827,iSF_1195.SF2704,iSFxv_1172.SFxv_2966,iS_1188.S2890	Bacteria	1MWUS@1224,1RN2N@1236,3XNJX@561,COG0208@1,COG0208@2	NA|NA|NA	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1_00458	469008.B21_02495	0.0	1413.7	Escherichia	nrdE	GO:0000166,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005971,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0015949,GO:0016020,GO:0016491,GO:0016725,GO:0016728,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0051063,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0071944,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990204	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400			iAPECO1_1312.APECO1_3846,iYO844.BSU17380	Bacteria	1MUJ8@1224,1RQQ6@1236,3XM5G@561,COG0209@1,COG0209@2	NA|NA|NA	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1_00459	155864.EDL933_3840	1.7e-72	278.5	Escherichia	nrdI	GO:0000166,GO:0003674,GO:0005488,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0010181,GO:0019538,GO:0032553,GO:0036094,GO:0036211,GO:0042221,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0048037,GO:0050662,GO:0050896,GO:0051716,GO:0070887,GO:0071241,GO:0071248,GO:0071281,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564		ko:K03647					ko00000				Bacteria	1RGYF@1224,1S3ZY@1236,3XPJI@561,COG1780@1,COG1780@2	NA|NA|NA	F	Probably involved in ribonucleotide reductase function
C1_00460	155864.EDL933_3839	1.1e-39	168.7	Escherichia	nrdH	GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009893,GO:0009987,GO:0016491,GO:0019222,GO:0019725,GO:0022900,GO:0042592,GO:0043085,GO:0044093,GO:0044237,GO:0045454,GO:0048518,GO:0050789,GO:0050790,GO:0050794,GO:0051341,GO:0051353,GO:0055114,GO:0065007,GO:0065008,GO:0065009		ko:K06191					ko00000				Bacteria	1N7YD@1224,1SCFR@1236,3XQ1Y@561,COG0695@1,COG0695@2	NA|NA|NA	O	Electron transport system for the ribonucleotide reductase system NrdEF
C1_00461	155864.EDL933_3836	2e-52	211.5	Escherichia	ygaM	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K05594,ko:K07184					ko00000				Bacteria	1RI01@1224,1S88Q@1236,3XPQJ@561,COG4575@1,COG4575@2	NA|NA|NA	S	ribosome binding
C1_00462	155864.EDL933_3835	3.1e-59	234.2	Escherichia	ygaC												Bacteria	1REJU@1224,1S4HA@1236,2DF7E@1,2ZQRR@2,3XPQW@561	NA|NA|NA	S	Protein of unknown function (DUF2002)
C1_00463	155864.EDL933_3834	2.5e-77	294.7	Escherichia	alaE	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015077,GO:0015078,GO:0015171,GO:0015179,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015562,GO:0015672,GO:0015711,GO:0015804,GO:0015807,GO:0015808,GO:0015849,GO:0016020,GO:0022804,GO:0022857,GO:0022890,GO:0032328,GO:0034220,GO:0034639,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:1902475,GO:1902600,GO:1903825,GO:1905039											Bacteria	1RF8A@1224,1RZCB@1236,2940Y@1,2ZRFS@2,3XP5F@561	NA|NA|NA	U	L-alanine exporter AlaE
C1_00464	155864.EDL933_3832	1.3e-61	242.3	Escherichia	stpA	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:1901363		ko:K03746,ko:K11685,ko:K20552	ko02020,ko02024,map02020,map02024				ko00000,ko00001,ko03036,ko03400				Bacteria	1RE55@1224,1S6P8@1236,3XPN4@561,COG2916@1,COG2916@2	NA|NA|NA	K	Hha and Cnu (YdgT) increases the number of genes DNA bound by H-NS StpA and may also modulate the oligomerization of the H-NS StpA-complex. Repression can be inhibited by dominant-negative mutants of StpA or H-NS
C1_00465	198214.SF2696	1.8e-90	338.6	Gammaproteobacteria	ygaP	GO:0003674,GO:0003824,GO:0004792,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0016740,GO:0016782,GO:0016783,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944											Bacteria	1RDIR@1224,1S3VJ@1236,COG0607@1,COG0607@2	NA|NA|NA	P	SMART Rhodanese domain protein
C1_00466	316407.1800053	1.4e-44	185.3	Escherichia	ygaV	GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0044212,GO:0097159,GO:1901363											Bacteria	1N72Q@1224,1SCH5@1236,3XPXI@561,COG0640@1,COG0640@2	NA|NA|NA	K	Transcriptional regulator
C1_00467	155864.EDL933_3829	1.5e-21	107.8	Escherichia	yqaE	GO:0008150,GO:0042221,GO:0046677,GO:0050896											Bacteria	1N7K3@1224,1SCD8@1236,3XQ3S@561,COG0401@1,COG0401@2	NA|NA|NA	S	Proteolipid membrane potential modulator
C1_00468	155864.EDL933_3828	5.5e-77	293.5	Escherichia	ygaU	GO:0003674,GO:0005488,GO:0005575,GO:0005576,GO:0008150,GO:0009892,GO:0009893,GO:0010035,GO:0010038,GO:0010468,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019222,GO:0030955,GO:0031420,GO:0035864,GO:0040008,GO:0040009,GO:0040010,GO:0042221,GO:0043167,GO:0043169,GO:0045927,GO:0046872,GO:0048518,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007		ko:K21687,ko:K21688,ko:K21689,ko:K21690,ko:K21691					ko00000		GH23		Bacteria	1RD8K@1224,1S4CB@1236,3XPJS@561,COG1652@1,COG1652@2	NA|NA|NA	S	response to potassium ion
C1_00469	155864.EDL933_3827	5.1e-119	433.7	Escherichia	csiR	GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141		ko:K15735					ko00000,ko03000				Bacteria	1Q85H@1224,1RZ0B@1236,3XNYQ@561,COG1802@1,COG1802@2	NA|NA|NA	K	Modulates expression of csiD and lhgO in a temporal manner during entry into stationary phase or during the first few hours of carbon starvation
C1_00470	316407.1800049	1.8e-254	884.8	Escherichia	gabP	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0033554,GO:0044464,GO:0050896,GO:0051716,GO:0071944		ko:K11735					ko00000,ko02000	2.A.3.1.4,2.A.3.1.5		iAPECO1_1312.APECO1_3857,iECABU_c1320.ECABU_c29260,iLF82_1304.LF82_0783,iNRG857_1313.NRG857_13035,iUTI89_1310.UTI89_C3018	Bacteria	1MUPS@1224,1RP97@1236,3XPEK@561,COG1113@1,COG1113@2	NA|NA|NA	E	4-amino butyrate transport carrier
C1_00471	155864.EDL933_3825	7.7e-241	839.3	Escherichia	gabT	GO:0001505,GO:0003674,GO:0003824,GO:0003867,GO:0003992,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009084,GO:0009448,GO:0009450,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016769,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0036094,GO:0042133,GO:0042135,GO:0042450,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0070279,GO:0071704,GO:0072329,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901607	2.6.1.19,2.6.1.22,2.6.1.48	ko:K00823,ko:K07250,ko:K14268	ko00250,ko00280,ko00310,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00310,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R02274,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007			iEC55989_1330.EC55989_2930,iECIAI1_1343.ECIAI1_2758,iECO111_1330.ECO111_3386,iECO26_1355.ECO26_3731,iSFxv_1172.SFxv_1480,iS_1188.S1389	Bacteria	1MWY6@1224,1RMP0@1236,3XNUA@561,COG0160@1,COG0160@2	NA|NA|NA	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C1_00472	155864.EDL933_3824	1.9e-272	944.5	Escherichia	gabD	GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0004777,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006105,GO:0006520,GO:0006536,GO:0006538,GO:0006540,GO:0006807,GO:0008150,GO:0008152,GO:0009013,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009448,GO:0009450,GO:0009987,GO:0016054,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0019752,GO:0032787,GO:0036094,GO:0042133,GO:0042135,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000			iECIAI39_1322.ECIAI39_2847,iYL1228.KPN_00256	Bacteria	1MU1V@1224,1RMBQ@1236,3XN8N@561,COG1012@1,COG1012@2	NA|NA|NA	C	Belongs to the aldehyde dehydrogenase family
C1_00473	155864.EDL933_3823	6.9e-242	842.8	Escherichia	lhgO	GO:0000166,GO:0003674,GO:0003824,GO:0003973,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016614,GO:0016899,GO:0034419,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071944,GO:0097159,GO:1901265,GO:1901363		ko:K15736					ko00000,ko01000				Bacteria	1N0QB@1224,1RN24@1236,3XPBR@561,COG0579@1,COG0579@2	NA|NA|NA	C	L-2-hydroxyglutarate oxidase LhgO
C1_00474	469008.B21_02479	2.9e-187	661.0	Escherichia	csiD	GO:0003674,GO:0005488,GO:0005506,GO:0005515,GO:0006950,GO:0008150,GO:0009605,GO:0009987,GO:0009991,GO:0016043,GO:0022607,GO:0031667,GO:0042594,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0046872,GO:0046914,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071840,GO:0090549		ko:K15737					ko00000				Bacteria	1MVXD@1224,1RQ5B@1236,2CG84@1,2Z8GB@2,3XQA6@561	NA|NA|NA	C	May be involved in the control of utilization of gamma- aminobutyric acid
C1_00475	481805.EcolC_1048	5.2e-107	394.4	Escherichia	dexB		2.4.1.7,3.2.1.20,3.2.1.51,3.2.1.70,3.2.1.93,3.2.1.97	ko:K00690,ko:K01187,ko:K01206,ko:K01215,ko:K01226,ko:K17624	ko00052,ko00500,ko00511,ko01100,map00052,map00500,map00511,map01100		R00028,R00801,R00802,R00803,R00837,R06087,R06088,R06113	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000,ko04147		GH101,GH13,GH29,GH31		Bacteria	1QFX7@1224,1TD8F@1236,3XQ81@561,COG0366@1,COG0366@2	NA|NA|NA	G	Alpha amylase, catalytic domain
C1_00476	1440052.EAKF1_ch3017c	4.5e-43	180.3	Escherichia		GO:0005575,GO:0005623,GO:0008150,GO:0009279,GO:0009405,GO:0016020,GO:0019867,GO:0030260,GO:0030312,GO:0030313,GO:0031975,GO:0044403,GO:0044409,GO:0044419,GO:0044462,GO:0044464,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0071944		ko:K07483					ko00000				Bacteria	1RHBZ@1224,1S69Y@1236,3XR2P@561,COG2963@1,COG2963@2	NA|NA|NA	L	transposase activity
C1_00477	1440052.EAKF1_ch3016c	3.7e-170	604.0	Escherichia				ko:K07497					ko00000				Bacteria	1MVXQ@1224,1RR4F@1236,3XQVK@561,COG2801@1,COG2801@2	NA|NA|NA	L	DDE domain
C1_00478	1073999.BN137_450	6.2e-278	963.0	Gammaproteobacteria	mutL	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	2.1.1.37,2.7.13.3	ko:K00558,ko:K03572,ko:K07637,ko:K07638,ko:K07717	ko00270,ko01100,ko01503,ko02020,ko02026,ko03430,ko05206,map00270,map01100,map01503,map02020,map02026,map03430,map05206	M00035,M00444,M00445,M00518,M00709,M00721,M00723,M00724,M00742,M00743,M00744	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022,ko02048,ko03032,ko03036,ko03400				Bacteria	1ND4X@1224,1RQA7@1236,COG0323@1,COG0323@2,COG4191@1,COG4191@2	NA|NA|NA	T	Histidine kinase
C1_00479	1073999.BN137_451	1.6e-249	868.6	Gammaproteobacteria													Bacteria	1PW2A@1224,1RZGH@1236,2A068@1,2ZBEM@2	NA|NA|NA		
C1_00480	1524467.IV04_21715	5.3e-58	230.3	Gammaproteobacteria													Bacteria	1NPBJ@1224,1SNNX@1236,2EQBM@1,33HXR@2	NA|NA|NA		
C1_00481	7213.XP_004532437.1	3.5e-214	750.7	Bilateria													Metazoa	2S871@2759,3AK9M@33154,3C03N@33208,3DG8M@33213,COG0582@1	NA|NA|NA	L	Arm DNA-binding domain
C1_00482	1323663.AROI01000005_gene3031	1.5e-44	187.6	Proteobacteria													Bacteria	1NDAD@1224,2BVNY@1,331B6@2	NA|NA|NA		
C1_00483	929814.E5G6L0_9CAUD	2.4e-189	667.9	Myoviridae		GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0015074,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:1901360											Viruses	4QAQE@10239,4QI35@10662,4QPDM@28883,4QUYF@35237	NA|NA|NA	S	DNA integration
C1_00484	220341.16505415	3.6e-66	258.1	Salmonella													Bacteria	1NDB9@1224,1RNJS@1236,3ZMPB@590,COG2932@1,COG2932@2	NA|NA|NA	K	Bacteriophage CI repressor C-terminal domain
C1_00485	1344012.ATMI01000051_gene1863	2.1e-22	111.3	Gammaproteobacteria													Bacteria	1NQ28@1224,1SJ63@1236,2DTF9@1,33K3P@2	NA|NA|NA		
C1_00486	929814.E5G6L3_9CAUD	1.2e-83	315.8	Myoviridae													Viruses	4QEAI@10239,4QJ4H@10662,4QS2J@28883,4QWIK@35237	NA|NA|NA	S	Phage regulatory protein CII (CP76)
C1_00487	199310.c0937	1.6e-31	141.4	Escherichia	fil												Bacteria	1N6WX@1224,1SDBV@1236,2E6E1@1,3311I@2,3XR7J@561	NA|NA|NA	S	Protein of unknown function (DUF2724)
C1_00488	220341.16504542	3.5e-55	220.7	Salmonella													Bacteria	1N9S6@1224,1SCSZ@1236,2ECF0@1,336D7@2,3ZNBW@590	NA|NA|NA	S	Family of unknown function (DUF5347)
C1_00489	199310.c0939	4.3e-33	146.7	Escherichia													Bacteria	1N59Y@1224,1SBKX@1236,2DI2J@1,32UA9@2,3XR35@561	NA|NA|NA	S	Protein of unknown function (DUF2732)
C1_00490	220341.16504544	5.9e-35	152.9	Salmonella				ko:K06204	ko02026,map02026				ko00000,ko00001,ko03000,ko03009,ko03021				Bacteria	1N7Q0@1224,1SDQT@1236,3ZMPK@590,COG1734@1,COG1734@2	NA|NA|NA	T	Prokaryotic dksA/traR C4-type zinc finger
C1_00491	929814.E5G6L8_9CAUD	7.7e-160	569.7	Myoviridae													Viruses	4QAXN@10239,4QI6Z@10662,4QPV1@28883,4QVNW@35237	NA|NA|NA	S	D12 class N6 adenine-specific DNA methyltransferase
C1_00492	929814.E5G6L9_9CAUD	0.0	1592.4	Myoviridae													Viruses	4QHQH@10239,4QK1N@10662,4QSJF@28883,4QY3V@35237	NA|NA|NA	L	Bacteriophage replication gene A protein (GPA)
C1_00493	481805.EcolC_2783	7e-26	122.5	Gammaproteobacteria													Bacteria	1NB8Q@1224,1SENK@1236,2EDXD@1,337SC@2	NA|NA|NA		
C1_00494	716541.ECL_04432	2.3e-34	151.0	Gammaproteobacteria				ko:K12149					ko00000,ko03400				Bacteria	1N4F6@1224,1SA0U@1236,2C6FZ@1,32S0J@2	NA|NA|NA	S	DinI-like family
C1_00495	371042.NG99_16035	2.7e-23	114.4	Gammaproteobacteria													Bacteria	1N6SI@1224,1SD4X@1236,2C59U@1,32Y4E@2	NA|NA|NA		
C1_00497	266265.Bxe_A2440	4.5e-57	228.0	Betaproteobacteria													Bacteria	1NF7Z@1224,2DNVB@1,2VYIG@28216,32ZBF@2	NA|NA|NA	S	Domain of unknown function (DUF4145)
C1_00498	220341.16504552	3.6e-188	664.1	Salmonella													Bacteria	1MWA5@1224,1RPXY@1236,3ZK9Z@590,COG4695@1,COG4695@2	NA|NA|NA	S	Phage portal protein
C1_00499	220341.16504553	0.0	1204.1	Salmonella													Bacteria	1MXYV@1224,1RMCC@1236,3ZM3I@590,COG4373@1,COG4373@2	NA|NA|NA	S	Terminase RNaseH-like domain
C1_00500	754331.AEME01000001_gene3569	6.3e-135	486.9	Escherichia													Bacteria	1RAGI@1224,1RYPG@1236,2CAV1@1,2ZBY8@2,3XQS3@561	NA|NA|NA	S	Phage capsid scaffolding protein (GPO) serine peptidase
C1_00501	754331.AEME01000001_gene3570	2.6e-194	684.5	Escherichia	N												Bacteria	1MUWR@1224,1RPKI@1236,2CCQ9@1,2Z7HY@2,3XQM7@561	NA|NA|NA	S	Major capsid protein
C1_00502	481805.EcolC_2774	2.8e-114	417.9	Escherichia													Bacteria	1RDUB@1224,1RRN1@1236,2DKUP@1,30DH1@2,3XQTS@561	NA|NA|NA	S	Phage small terminase subunit
C1_00503	754331.AEME01000001_gene3572	5.3e-83	313.5	Escherichia	L												Bacteria	1N0DS@1224,1S9D3@1236,2CM6Y@1,32SDV@2,3XQUN@561	NA|NA|NA	S	Phage head completion protein (GPL)
C1_00504	199310.c0955	8.4e-33	145.6	Gammaproteobacteria	X												Bacteria	1N81H@1224,1SCK4@1236,COG5004@1,COG5004@2	NA|NA|NA	S	tail protein x
C1_00505	220341.16504559	7.5e-32	142.5	Gammaproteobacteria													Bacteria	1N27K@1224,1SE5W@1236,2DZJ9@1,32VC7@2	NA|NA|NA	S	Bacteriophage holin family HP1
C1_00506	481805.EcolC_2770	7.5e-94	349.7	Gammaproteobacteria	nucD		3.2.1.17	ko:K01185					ko00000,ko01000				Bacteria	1MZJD@1224,1S2FS@1236,COG3772@1,COG3772@2	NA|NA|NA	G	lysozyme
C1_00507	481805.EcolC_2769	3e-64	251.1	Proteobacteria	lysB												Bacteria	1RCJI@1224,2DRCZ@1,33B9B@2	NA|NA|NA	S	regulatory protein
C1_00508	220341.16504563	1e-75	289.3	Salmonella													Bacteria	1MZ82@1224,1S5DY@1236,2CBI4@1,32RTF@2,3ZMP1@590	NA|NA|NA	S	P2 phage tail completion protein R (GpR)
C1_00509	220341.16504564	1.6e-60	238.8	Salmonella													Bacteria	1MZCV@1224,1S4IA@1236,3ZMM8@590,COG5005@1,COG5005@2	NA|NA|NA	S	Phage virion morphogenesis family
C1_00511	199310.c0963	4e-105	387.5	Escherichia													Bacteria	1N2WK@1224,1RRER@1236,3XQFM@561,COG4540@1,COG4540@2	NA|NA|NA	S	Type VI secretion system, phage-baseplate injector
C1_00512	754331.AEME01000001_gene3581	3e-57	227.6	Escherichia	w3			ko:K06903					ko00000				Bacteria	1N7WS@1224,1SCD1@1236,3XQY7@561,COG3628@1,COG3628@2	NA|NA|NA	S	Gene 25-like lysozyme
C1_00513	469008.B21_00849	1.2e-158	565.8	Escherichia													Bacteria	1MUFF@1224,1RNBJ@1236,3XQVU@561,COG3948@1,COG3948@2	NA|NA|NA	S	Baseplate J-like protein
C1_00514	481805.EcolC_2762	2.6e-114	417.9	Escherichia	gpI												Bacteria	1NZST@1224,1RQRK@1236,3XQQ5@561,COG4385@1,COG4385@2	NA|NA|NA	S	Phage tail protein (Tail_P2_I)
C1_00515	481805.EcolC_2761	4.5e-186	657.5	Escherichia													Bacteria	1MWNN@1224,1RR74@1236,3XQD4@561,COG5301@1,COG5301@2	NA|NA|NA	S	Phage tail-collar fibre protein
C1_00516	1407493.U5P0S4_9CAUD	1.3e-24	119.4	Myoviridae													Viruses	4QAIQ@10239,4QHZ2@10662,4QQA2@28883,4QWCG@35237	NA|NA|NA	S	Caudovirales tail fibre assembly protein
C1_00517	155864.EDL933_0286	1.3e-78	298.9	Escherichia	yfdK	GO:0006950,GO:0006979,GO:0008150,GO:0050896											Bacteria	1N14T@1224,1SB31@1236,2DMUG@1,32TR7@2,3XREF@561	NA|NA|NA	S	response to oxidative stress
C1_00518	220341.16503856	1.4e-98	365.5	Salmonella	pin												Bacteria	1MXXT@1224,1S08N@1236,3ZMPS@590,COG1961@1,COG1961@2	NA|NA|NA	L	Resolvase, N terminal domain
C1_00519	220341.16503855	5.3e-220	770.0	Salmonella				ko:K06907					ko00000				Bacteria	1MW1V@1224,1RNUT@1236,3ZJI0@590,COG3497@1,COG3497@2	NA|NA|NA	S	Phage tail sheath C-terminal domain
C1_00520	199310.c0972	2e-91	341.7	Escherichia	FII			ko:K06908					ko00000				Bacteria	1Q8HB@1224,1RPNF@1236,3XQR8@561,COG3498@1,COG3498@2	NA|NA|NA	S	Phage tail tube protein FII
C1_00521	199310.c0974	1.9e-44	184.9	Escherichia													Bacteria	1N720@1224,1SCI4@1236,2E3XV@1,32YUV@2,3XR14@561	NA|NA|NA	S	Phage tail assembly chaperone proteins, E, or 41 or 14
C1_00522	754331.AEME01000001_gene1667	0.0	1681.8	Escherichia													Bacteria	1NFKU@1224,1RP2D@1236,3XQPK@561,COG5283@1,COG5283@2	NA|NA|NA	S	Phage tail tape measure protein, TP901 family
C1_00523	481805.EcolC_2752	2.5e-83	314.7	Escherichia	gpU			ko:K06906					ko00000				Bacteria	1MZJ7@1224,1S3NI@1236,3XQ7W@561,COG3499@1,COG3499@2	NA|NA|NA	S	Phage P2 GpU
C1_00524	1440052.EAKF1_ch3372	8.8e-201	706.1	Escherichia				ko:K06905					ko00000				Bacteria	1MXT8@1224,1RMKC@1236,3XQGT@561,COG3500@1,COG3500@2	NA|NA|NA	S	Phage late control gene D protein (GPD)
C1_00526	1440052.EAKF1_ch3373c	3.1e-86	324.3	Gammaproteobacteria	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430		R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400				Bacteria	1R145@1224,1SDFQ@1236,COG0272@1,COG0272@2	NA|NA|NA	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C1_00529	1440052.EAKF1_ch3375c	2e-85	321.6	Escherichia	smpB	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0070930,GO:0071704,GO:0097159,GO:1901363,GO:1901564		ko:K03664					ko00000				Bacteria	1RDFP@1224,1S3PT@1236,3XN6W@561,COG0691@1,COG0691@2	NA|NA|NA	J	the nascent peptide is terminated with the tag peptide encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans- translation
C1_00530	155864.EDL933_3780	3.9e-81	307.4	Escherichia	ratA	GO:0003674,GO:0005488,GO:0006417,GO:0006446,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044877,GO:0045947,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:2000112,GO:2000113		ko:K18588					ko00000				Bacteria	1RGUH@1224,1S61C@1236,3XNWI@561,COG2867@1,COG2867@2	NA|NA|NA	I	Toxic component of a type II toxin-antitoxin (TA) system. Binds to 50S ribosomal subunits, preventing them from associating with 30S subunits to form 70S ribosomes and reducing polysomes. It does not cause ribosomes to dissociate however. The antibiotic paromomycin blocks the anti-association activity of RatA. Overexpression results in inhibition of growth in liquid cultures, and in a decrease in protein translation. The other gene of this operon, ratB, is not the cognate antitoxin in this strain
C1_00531	316407.1800023	6.1e-45	186.4	Escherichia	rnfH			ko:K03154,ko:K09801	ko04122,map04122				ko00000,ko00001				Bacteria	1MZCH@1224,1SCHG@1236,3XPXJ@561,COG2914@1,COG2914@2	NA|NA|NA	S	RnfH family Ubiquitin
C1_00532	1440052.EAKF1_ch3378c	8.2e-57	226.1	Escherichia	bamE	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0030674,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0042221,GO:0042802,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045203,GO:0045229,GO:0046677,GO:0050896,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0060090,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063		ko:K06186					ko00000,ko02000	1.B.33.1			Bacteria	1N6YW@1224,1SCTT@1236,3XPQ8@561,COG2913@1,COG2913@2	NA|NA|NA	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1_00533	316407.1800021	1.6e-307	1061.2	Escherichia	recN	GO:0000724,GO:0000725,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009295,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360		ko:K03631					ko00000,ko03400				Bacteria	1MUNP@1224,1RNPZ@1236,3XM2H@561,COG0497@1,COG0497@2	NA|NA|NA	L	May be involved in recombinational repair of damaged DNA
C1_00534	198214.SF2674	5.1e-167	593.6	Gammaproteobacteria	nadK	GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100		R00104	RC00002,RC00078	ko00000,ko00001,ko01000			iEcSMS35_1347.EcSMS35_2767,iHN637.CLJU_RS05480,iLJ478.TM1733,iSB619.SA_RS04895	Bacteria	1MUBC@1224,1RP84@1236,COG0061@1,COG0061@2	NA|NA|NA	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C1_00535	155864.EDL933_3774	2.2e-97	361.7	Escherichia	grpE	GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0007154,GO:0008150,GO:0009266,GO:0009267,GO:0009408,GO:0009605,GO:0009628,GO:0009986,GO:0009987,GO:0009991,GO:0016043,GO:0017076,GO:0019904,GO:0022607,GO:0030234,GO:0030246,GO:0030247,GO:0030312,GO:0030554,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0033554,GO:0036094,GO:0040007,GO:0042594,GO:0042802,GO:0042803,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0050790,GO:0050896,GO:0051082,GO:0051716,GO:0060589,GO:0060590,GO:0065003,GO:0065007,GO:0065009,GO:0071496,GO:0071840,GO:0071944,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065		ko:K03687					ko00000,ko03029,ko03110				Bacteria	1RH8T@1224,1S5W5@1236,3XM4I@561,COG0576@1,COG0576@2	NA|NA|NA	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C1_00536	481805.EcolC_1071	1.6e-222	778.5	Escherichia	yfjD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03699					ko00000,ko02042				Bacteria	1NZ99@1224,1RNCE@1236,3XMRP@561,COG4536@1,COG4536@2	NA|NA|NA	P	flavin adenine dinucleotide binding
C1_00537	155864.EDL933_3772	5.4e-153	547.0	Escherichia	ypjD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1R3YD@1224,1RPUQ@1236,3XP10@561,COG4137@1,COG4137@2	NA|NA|NA	S	cytochrome complex assembly
C1_00538	155864.EDL933_3771	4.5e-247	860.1	Escherichia	ffh	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006605,GO:0006612,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0030312,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0040007,GO:0042886,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046907,GO:0048500,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0071944,GO:0072657,GO:0090150,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1990904	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9			Bacteria	1MVIA@1224,1RMU9@1236,3XNYY@561,COG0541@1,COG0541@2	NA|NA|NA	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components
C1_00539	1440052.EAKF1_ch3387	4.8e-38	163.3	Escherichia	rpsP	GO:0000028,GO:0000217,GO:0000400,GO:0003674,GO:0003676,GO:0003677,GO:0003735,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006259,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016787,GO:0016788,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02959	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011,ko03029				Bacteria	1MZCT@1224,1S8RT@1236,3XPX7@561,COG0228@1,COG0228@2	NA|NA|NA	J	In addition to being a ribosomal protein, S16 also has a cation-dependent endonuclease activity
C1_00540	155864.EDL933_3769	2.3e-101	374.8	Escherichia	rimM	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360		ko:K02860					ko00000,ko03009				Bacteria	1MWQR@1224,1RNJ2@1236,3XNNP@561,COG0806@1,COG0806@2	NA|NA|NA	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C1_00541	155864.EDL933_3768	4e-144	517.3	Escherichia	trmD	GO:0000287,GO:0001510,GO:0002939,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050518,GO:0052906,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228,4.6.1.12	ko:K00554,ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R00597,R05637	RC00002,RC00003,RC00334,RC01440	ko00000,ko00001,ko00002,ko01000,ko03016				Bacteria	1MUN1@1224,1RMWC@1236,3XM2W@561,COG0336@1,COG0336@2	NA|NA|NA	J	Belongs to the RNA methyltransferase TrmD family
C1_00542	155864.EDL933_3767	2.1e-55	221.5	Escherichia	rplS	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02884	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1RH3A@1224,1S5XX@1236,3XPQX@561,COG0335@1,COG0335@2	NA|NA|NA	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
C1_00543	469008.B21_02458	3.5e-85	320.9	Escherichia	yfiB			ko:K03286					ko00000,ko02000	1.B.6			Bacteria	1RJ05@1224,1S695@1236,3XNC2@561,COG2885@1,COG2885@2	NA|NA|NA	M	Belongs to the ompA family
C1_00544	316407.85675478	6.1e-227	793.1	Escherichia	yfiN	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0032153,GO:0032879,GO:0033554,GO:0036460,GO:0040012,GO:0040013,GO:0042802,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051270,GO:0051271,GO:0051716,GO:0052621,GO:0065007,GO:0071944,GO:1902021,GO:1902201,GO:2000145,GO:2000146	2.7.7.65	ko:K21021	ko02025,map02025				ko00000,ko00001,ko01000				Bacteria	1MXY1@1224,1RXYD@1236,3XMQ6@561,COG2199@1,COG2199@2	NA|NA|NA	T	cellular response to cell envelope stress
C1_00545	155864.EDL933_3764	6e-91	340.1	Escherichia	yfiR	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588											Bacteria	1N04T@1224,1S4KR@1236,2BSVP@1,32MZ8@2,3XPY8@561	NA|NA|NA	S	bacterial-type flagellum-dependent swarming motility
C1_00546	316407.1800008	5.7e-64	250.0	Escherichia	yfiL												Bacteria	1N2Z7@1224,1SEVD@1236,2ED5M@1,3372C@2,3XPR7@561	NA|NA|NA	S	Protein of unknown function (DUF2799)
C1_00547	199310.c3122	2.9e-201	707.6	Escherichia	aroF	GO:0003674,GO:0003824,GO:0003849,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019438,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_2375,iAPECO1_1312.APECO1_3932,iECOK1_1307.ECOK1_2946,iECS88_1305.ECS88_2787,iLF82_1304.LF82_0146,iNRG857_1313.NRG857_03335,iSbBS512_1146.SbBS512_E1908,iUMN146_1321.UM146_03705,iUTI89_1310.UTI89_C2934	Bacteria	1MU5Q@1224,1RMAA@1236,3XMUR@561,COG0722@1,COG0722@2	NA|NA|NA	E	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1_00548	469008.B21_02453	6.8e-209	733.0	Escherichia	tyrA	GO:0000166,GO:0003674,GO:0003824,GO:0004106,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008977,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0071944,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223	1.3.1.12,1.3.1.13,1.3.1.43,5.4.99.5	ko:K00210,ko:K00211,ko:K00220,ko:K04092,ko:K04093,ko:K04517,ko:K14187	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00024,M00025,M00040	R00732,R01715,R01728,R01730	RC00125,RC03116	ko00000,ko00001,ko00002,ko01000			iECUMN_1333.ECUMN_2925	Bacteria	1MVUT@1224,1RQB3@1236,3XNQD@561,COG0287@1,COG0287@2,COG1605@1,COG1605@2	NA|NA|NA	E	T-protein
C1_00549	155864.EDL933_3760	5.6e-214	750.0	Escherichia	pheA	GO:0003674,GO:0003824,GO:0004106,GO:0004664,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223	1.3.1.12,2.3.1.79,2.5.1.54,4.2.1.51,5.4.99.5	ko:K00661,ko:K03856,ko:K04092,ko:K04093,ko:K04516,ko:K04518,ko:K14170,ko:K14187	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00022,M00024,M00025	R00691,R01373,R01715,R01728,R01826	RC00125,RC00360,RC00435,RC03116	ko00000,ko00001,ko00002,ko01000			iECNA114_1301.ECNA114_2667	Bacteria	1MU60@1224,1RNRD@1236,3XNP0@561,COG0077@1,COG0077@2,COG1605@1,COG1605@2	NA|NA|NA	E	Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation dehydration of prephenate to phenylpyruvate
C1_00550	1440052.EAKF1_ch3398c	2.6e-55	221.1	Escherichia	hpf	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006446,GO:0006448,GO:0006950,GO:0008150,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0045947,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113		ko:K05808,ko:K05809					ko00000,ko03009				Bacteria	1RD2Y@1224,1S6GT@1236,3XPTC@561,COG1544@1,COG1544@2	NA|NA|NA	J	During stationary phase prevents 70S dimer formation, probably in order to regulate translation efficiency during transition between the exponential and the stationary phases. During environmental stress such as cold shock or excessive cell density at stationary phase, stabilizes the 70S ribosome against dissociation, inhibits translation elongation and increases translation accuracy. When normal growth conditions are restored, is quickly released from the ribosome. Has been suggested to inhibit translation elongation by blocking the A-site (aminoacyl-tRNA site). Has also been suggested to inhibit translation initiation by blocking the A-site and P-site (peptidyl-tRNA site) of the ribosome. At 15 degrees Celsius binds 30S subunits and stimulates their association with 50S subunits into idle 70S ribosomes. Crystallization with T.thermophilus 70S ribosomes shows it binds in the channel between the head and body of the 30S subunit, where mRNA, tRNAs, initiation factors IF1 and IF3 and elongation factor G would bind
C1_00551	155864.EDL933_3758	8.7e-136	489.6	Escherichia	bamD	GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063		ko:K05807,ko:K08309					ko00000,ko01000,ko01011,ko02000	1.B.33.1	GH23		Bacteria	1MVS5@1224,1RSE6@1236,3XN5M@561,COG4105@1,COG4105@2	NA|NA|NA	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamA, the core component of the assembly machinery
C1_00552	198214.SF2653	3.9e-184	650.6	Gammaproteobacteria	rluD	GO:0000027,GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022607,GO:0022613,GO:0022618,GO:0031118,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360	5.4.99.23,5.4.99.28,5.4.99.29	ko:K06177,ko:K06180					ko00000,ko01000,ko03009,ko03016			iE2348C_1286.E2348C_2868,iECED1_1282.ECED1_3035,iECSF_1327.ECSF_2432	Bacteria	1MUBN@1224,1RN7F@1236,COG0564@1,COG0564@2	NA|NA|NA	J	Responsible for synthesis of pseudouridine from uracil
C1_00553	199310.c3115	3.7e-139	500.7	Escherichia	yfiH	GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016679,GO:0016682,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0046983,GO:0055114		ko:K05810					ko00000,ko01000				Bacteria	1MW2H@1224,1RNV4@1236,3XPG0@561,COG1496@1,COG1496@2	NA|NA|NA	S	Belongs to the multicopper oxidase YfiH RL5 family
C1_00554	155864.EDL933_3755	0.0	1636.3	Escherichia	clpB	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0010033,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0035966,GO:0042221,GO:0042623,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896		ko:K03694,ko:K03695	ko04213,map04213				ko00000,ko00001,ko03110				Bacteria	1MURH@1224,1RN55@1236,3XN3I@561,COG0542@1,COG0542@2	NA|NA|NA	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
C1_00559	198214.SF2649	3.3e-239	833.9	Gammaproteobacteria	kgtP	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0016020,GO:0022804,GO:0022857,GO:0022890,GO:0034220,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098655		ko:K02625,ko:K03761,ko:K03762,ko:K08173					ko00000,ko02000	2.A.1.6,2.A.1.6.2,2.A.1.6.3,2.A.1.6.4		e_coli_core.b2587,iAF1260.b2587,iB21_1397.B21_02445,iBWG_1329.BWG_2351,iEC55989_1330.EC55989_2877,iECBD_1354.ECBD_1093,iECB_1328.ECB_02481,iECDH10B_1368.ECDH10B_2755,iECDH1ME8569_1439.ECDH1ME8569_2514,iECD_1391.ECD_02481,iECIAI1_1343.ECIAI1_2705,iECIAI39_1322.ECIAI39_2795,iECO103_1326.ECO103_3166,iECO111_1330.ECO111_3313,iECO26_1355.ECO26_3634,iECW_1372.ECW_m2816,iEKO11_1354.EKO11_1146,iETEC_1333.ETEC_2800,iEcDH1_1363.EcDH1_1081,iEcE24377_1341.EcE24377A_2873,iEcolC_1368.EcolC_1090,iJO1366.b2587,iJR904.b2587,iSBO_1134.SBO_2619,iSDY_1059.SDY_2830,iSF_1195.SF2649,iSFxv_1172.SFxv_2906,iS_1188.S2822,iUMNK88_1353.UMNK88_3239,iUTI89_1310.UTI89_C4705,iWFL_1372.ECW_m2816,iY75_1357.Y75_RS13520,iYL1228.KPN_02910,ic_1306.c5116	Bacteria	1MVZG@1224,1RS8V@1236,COG0477@1,COG0477@2	NA|NA|NA	EGP	transporter
C1_00560	316407.1799989	6.8e-46	189.5	Escherichia	yfiM			ko:K05811					ko00000				Bacteria	1N1EG@1224,1S9DQ@1236,3XPUA@561,COG5544@1,COG5544@2	NA|NA|NA	S	Predicted periplasmic lipoprotein (DUF2279)
C1_00561	155864.EDL933_3750	3.8e-262	910.2	Escherichia	pssA	GO:0003674,GO:0003824,GO:0003882,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.7.8.8	ko:K00998,ko:K06131,ko:K06132	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800,R07390,R11062	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000			iECED1_1282.ECED1_0754,iECH74115_1262.ECH74115_3822,iECSP_1301.ECSP_3532,iSDY_1059.SDY_1307,iYL1228.KPN_02908	Bacteria	1MVPU@1224,1RN1V@1236,3XP42@561,COG1502@1,COG1502@2	NA|NA|NA	I	CDP-diacylglycerol-serine O-phosphatidyltransferase activity
C1_00562	316407.85675472	0.0	1739.2	Escherichia	yfiQ	GO:0003674,GO:0003824,GO:0006464,GO:0006473,GO:0006475,GO:0006807,GO:0006950,GO:0006979,GO:0008080,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0018193,GO:0018205,GO:0018393,GO:0018394,GO:0019538,GO:0022607,GO:0032459,GO:0032462,GO:0034212,GO:0036211,GO:0043170,GO:0043254,GO:0043412,GO:0043543,GO:0043933,GO:0044085,GO:0044087,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0052858,GO:0061733,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:1901564	6.2.1.13	ko:K01905,ko:K09181,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120		R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004				Bacteria	1MW98@1224,1RPXX@1236,3XPBY@561,COG0045@1,COG0045@2,COG1042@1,COG1042@2,COG1670@1,COG1670@2	NA|NA|NA	CJ	Acetylates RNase R in exponential phase cells. Also required for the glucose-dependent acetylation on multiple lysines of alpha, beta and beta' RNAP subunits. May acetylate Acs and inhibit its activity
C1_00563	155864.EDL933_3748	1.8e-127	461.8	Escherichia	yfiP			ko:K05812					ko00000				Bacteria	1N8XY@1224,1RS6H@1236,3XMFX@561,COG3148@1,COG3148@2	NA|NA|NA	S	DTW
C1_00564	155864.EDL933_3747	2.3e-77	294.7	Escherichia	trxC	GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008270,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0046872,GO:0046914,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.8.1.8	ko:K03672					ko00000,ko01000,ko03110			iAF1260.b2582,iAPECO1_1312.APECO1_3950,iB21_1397.B21_02440,iBWG_1329.BWG_2346,iE2348C_1286.E2348C_2859,iEC55989_1330.EC55989_2872,iECABU_c1320.ECABU_c28840,iECBD_1354.ECBD_1098,iECB_1328.ECB_02476,iECDH10B_1368.ECDH10B_2750,iECDH1ME8569_1439.ECDH1ME8569_2509,iECD_1391.ECD_02476,iECH74115_1262.ECH74115_3819,iECIAI1_1343.ECIAI1_2700,iECIAI39_1322.ECIAI39_2790,iECO103_1326.ECO103_3161,iECO111_1330.ECO111_3308,iECO26_1355.ECO26_3629,iECOK1_1307.ECOK1_2926,iECP_1309.ECP_2584,iECS88_1305.ECS88_2757,iECSE_1348.ECSE_2871,iECSF_1327.ECSF_2421,iECSP_1301.ECSP_3529,iECW_1372.ECW_m2811,iECs_1301.ECs3448,iEKO11_1354.EKO11_1151,iEcDH1_1363.EcDH1_1086,iEcE24377_1341.EcE24377A_2869,iEcHS_1320.EcHS_A2739,iEcSMS35_1347.EcSMS35_2735,iEcolC_1368.EcolC_1095,iG2583_1286.G2583_3165,iJO1366.b2582,iLF82_1304.LF82_2324,iNRG857_1313.NRG857_12825,iSDY_1059.SDY_2825,iSFV_1184.SFV_2645,iSF_1195.SF2644,iSFxv_1172.SFxv_2901,iSSON_1240.SSON_2708,iS_1188.S2817,iSbBS512_1146.SbBS512_E2954,iUMN146_1321.UM146_03805,iUMNK88_1353.UMNK88_3235,iUTI89_1310.UTI89_C2905,iWFL_1372.ECW_m2811,iY75_1357.Y75_RS13495,iZ_1308.Z3867,ic_1306.c3107	Bacteria	1RHUA@1224,1S64W@1236,3XP1C@561,COG3118@1,COG3118@2	NA|NA|NA	O	Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin
C1_00565	155864.EDL933_3746	7.3e-197	693.0	Escherichia	yfiF	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.185,2.1.1.34	ko:K00556,ko:K03214,ko:K03218					ko00000,ko01000,ko03009,ko03016				Bacteria	1MXGV@1224,1RNWQ@1236,3XP5W@561,COG0566@1,COG0566@2	NA|NA|NA	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1_00566	316407.1799984	4.9e-133	480.3	Escherichia	ung	GO:0003674,GO:0003824,GO:0004844,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0097510,GO:0140097,GO:1901360	3.2.2.27	ko:K03648	ko03410,ko05340,map03410,map05340				ko00000,ko00001,ko01000,ko03400				Bacteria	1MV80@1224,1RPDH@1236,3XMVQ@561,COG0692@1,COG0692@2	NA|NA|NA	L	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C1_00567	155864.EDL933_3744	3.5e-64	250.8	Escherichia	grcA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006566,GO:0006567,GO:0006807,GO:0008150,GO:0008152,GO:0008861,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009987,GO:0016054,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.14.13.236	ko:K06866,ko:K15763,ko:K22361	ko00623,ko00625,ko01100,ko01120,ko01220,map00623,map00625,map01100,map01120,map01220	M00538	R02550,R03562,R05444,R05666,R11901	RC00269,RC00490,RC01383	ko00000,ko00001,ko00002,ko01000			iSF_1195.SF2641,iSFxv_1172.SFxv_2898,iS_1188.S2814	Bacteria	1RDRB@1224,1S45G@1236,3XPJB@561,COG3445@1,COG3445@2	NA|NA|NA	S	Acts as a radical domain for damaged PFL and possibly other radical proteins
C1_00568	316407.1799982	2.5e-101	374.8	Escherichia	eamB	GO:0000099,GO:0000101,GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015175,GO:0015318,GO:0015711,GO:0015804,GO:0015849,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0032973,GO:0033228,GO:0033229,GO:0034220,GO:0042883,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0098655,GO:0098656,GO:0140115,GO:1901682,GO:1903712,GO:1903825,GO:1905039		ko:K11249					ko00000,ko02000	2.A.76.1.4		iSFV_1184.SFV_2641,iSF_1195.SF2640,iS_1188.S2813	Bacteria	1RCFI@1224,1T02N@1236,3XQ56@561,COG1280@1,COG1280@2	NA|NA|NA	U	Cysteine O-acetylserine efflux protein
C1_00569	316407.85675468	9.3e-161	572.8	Escherichia	yfiE	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576											Bacteria	1P8X0@1224,1RPH4@1236,3XQM4@561,COG0583@1,COG0583@2	NA|NA|NA	K	Transcriptional regulator
C1_00570	637910.ROD_00481	2.1e-161	575.1	Gammaproteobacteria	piv			ko:K07486					ko00000				Bacteria	1MXKJ@1224,1RSCP@1236,COG3547@1,COG3547@2	NA|NA|NA	L	Transposase
C1_00571	155864.EDL933_3741	1.7e-235	821.6	Escherichia	srmB	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003724,GO:0003725,GO:0003727,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008104,GO:0008143,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0033036,GO:0033592,GO:0034622,GO:0034641,GO:0035770,GO:0036464,GO:0042254,GO:0042255,GO:0042273,GO:0042623,GO:0043170,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0046483,GO:0051179,GO:0060293,GO:0065003,GO:0070035,GO:0070717,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:0097617,GO:0140098,GO:1901360,GO:1901363,GO:1990904	3.6.4.13	ko:K05590,ko:K11927	ko03018,map03018				ko00000,ko00001,ko01000,ko03009,ko03019				Bacteria	1MU49@1224,1RMWA@1236,3XNKW@561,COG0513@1,COG0513@2	NA|NA|NA	F	DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit at low temperature. Exhibits RNA-stimulated ATP hydrolysis and RNA unwinding activity
C1_00572	198214.SF2637	2.4e-138	498.0	Gammaproteobacteria	yfiC	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016426,GO:0016430,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.223,2.1.1.72	ko:K00571,ko:K15460					ko00000,ko01000,ko02048,ko03016				Bacteria	1PC8R@1224,1RM8S@1236,COG4123@1,COG4123@2	NA|NA|NA	J	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C1_00573	316407.85675465	0.0	1097.8	Escherichia	nadB	GO:0000166,GO:0001716,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008734,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0015922,GO:0016491,GO:0016638,GO:0016641,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044318,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605	1.3.5.4,1.4.3.16	ko:K00244,ko:K00278	ko00020,ko00190,ko00250,ko00620,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00250,map00620,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00115,M00150,M00173	R00357,R00481,R02164	RC00006,RC00045,RC02566	ko00000,ko00001,ko00002,ko01000			iAF1260.b2574,iBWG_1329.BWG_2338,iECDH10B_1368.ECDH10B_2742,iECDH1ME8569_1439.ECDH1ME8569_2501,iETEC_1333.ETEC_2787,iEcDH1_1363.EcDH1_1094,iJN678.nadB,iJO1366.b2574,iJR904.b2574,iLF82_1304.LF82_1433,iNRG857_1313.NRG857_12785,iSbBS512_1146.nadB,iY75_1357.Y75_RS13445,iYL1228.KPN_02899	Bacteria	1RBQW@1224,1RMMD@1236,3XMYY@561,COG0029@1,COG0029@2	NA|NA|NA	H	Catalyzes the oxidation of L-aspartate to iminoaspartate
C1_00574	1440052.EAKF1_ch3429	7.8e-100	369.8	Escherichia	rpoE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0006950,GO:0006970,GO:0008150,GO:0009266,GO:0009628,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141		ko:K03088					ko00000,ko03021				Bacteria	1MX7T@1224,1RN64@1236,3XNWB@561,COG1595@1,COG1595@2	NA|NA|NA	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase (RNAP) to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma-E controls the envelope stress response, responding to periplasmic protein stress, increased levels of periplasmic lipopolysaccharide (LPS) as well as heat shock and oxidative stress
C1_00575	199310.c3096	4.1e-105	387.5	Escherichia	rseA	GO:0000988,GO:0000989,GO:0003674,GO:0008150,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141		ko:K03597					ko00000,ko03021				Bacteria	1R4U0@1224,1RN98@1236,3XMZ1@561,COG3073@1,COG3073@2	NA|NA|NA	T	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
C1_00576	155864.EDL933_3736	9.4e-175	619.4	Escherichia	rseB	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0044464,GO:0045152		ko:K03598					ko00000,ko03021				Bacteria	1MUQ8@1224,1RNF3@1236,3XN4S@561,COG3026@1,COG3026@2	NA|NA|NA	T	Negatively modulates the activity of sigma-E (RpoE) by stabilizing RseA under non-stress conditions. Although not essential for association of sigma-E with Rsea it increases their affinity 2- to 3-fold. When bound to RseA it prevents proteolysis by DegS, which is probably relieved by lipopolysaccharide binding (LPS)
C1_00577	155864.EDL933_3735	2.3e-81	308.1	Escherichia	rseC	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0016020,GO:0044464,GO:0050896,GO:0071944		ko:K03803					ko00000,ko03021				Bacteria	1N6QS@1224,1SCTM@1236,3XPGD@561,COG3086@1,COG3086@2	NA|NA|NA	T	Sigma-E factor regulatory protein RseC
C1_00578	155864.EDL933_3734	0.0	1182.2	Escherichia	lepA	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0006950,GO:0006970,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009268,GO:0009409,GO:0009628,GO:0009651,GO:0009987,GO:0010467,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0042802,GO:0043021,GO:0043023,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0050896,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576		ko:K03596	ko05134,map05134				ko00000,ko00001				Bacteria	1MVZA@1224,1RPFB@1236,3XNWA@561,COG0481@1,COG0481@2	NA|NA|NA	J	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
C1_00579	155864.EDL933_3733	8.9e-189	666.0	Escherichia	lepB	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006465,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009987,GO:0010467,GO:0015643,GO:0016020,GO:0016021,GO:0016485,GO:0016787,GO:0017171,GO:0019538,GO:0031224,GO:0031226,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0051604,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060				ko00000,ko00001,ko01000,ko01002				Bacteria	1MXUF@1224,1RMHI@1236,3XM5W@561,COG0681@1,COG0681@2	NA|NA|NA	U	Belongs to the peptidase S26 family
C1_00580	155864.EDL933_3732	1.7e-122	445.3	Escherichia	rnc	GO:0000287,GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016072,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019899,GO:0022613,GO:0032296,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205				ko00000,ko00001,ko01000,ko03009,ko03019,ko03036				Bacteria	1MUQ6@1224,1RN0C@1236,3XNWX@561,COG0571@1,COG0571@2	NA|NA|NA	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
C1_00581	199310.c3090	3.1e-167	594.3	Escherichia	era	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009898,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0019843,GO:0019897,GO:0019898,GO:0022613,GO:0031234,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0036211,GO:0042254,GO:0042274,GO:0043021,GO:0043024,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044877,GO:0046777,GO:0070181,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363,GO:1901564		ko:K03595					ko00000,ko03009,ko03029				Bacteria	1MUKT@1224,1RN3A@1236,3XNW1@561,COG1159@1,COG1159@2	NA|NA|NA	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C1_00582	155864.EDL933_3730	1.8e-133	481.9	Escherichia	recO	GO:0008150,GO:0009314,GO:0009628,GO:0050896	2.6.99.2	ko:K03474,ko:K03584	ko00750,ko01100,ko03440,map00750,map01100,map03440	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000,ko03400				Bacteria	1RHIC@1224,1RN8Y@1236,3XMYF@561,COG1381@1,COG1381@2	NA|NA|NA	L	Involved in DNA repair and RecF pathway recombination
C1_00583	1440052.EAKF1_ch3438	1.1e-130	472.6	Escherichia	pdxJ	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000			iAF1260.b2564,iAF987.Gmet_1885,iB21_1397.B21_02422,iBWG_1329.BWG_2328,iEC55989_1330.EC55989_2852,iECBD_1354.ECBD_1117,iECB_1328.ECB_02458,iECDH10B_1368.ECDH10B_2732,iECDH1ME8569_1439.ECDH1ME8569_2491,iECD_1391.ECD_02458,iECH74115_1262.ECH74115_3800,iECIAI1_1343.ECIAI1_2675,iECO103_1326.ECO103_3142,iECO111_1330.ECO111_3290,iECO26_1355.ECO26_3611,iECSE_1348.ECSE_2852,iECSP_1301.ECSP_3509,iECW_1372.ECW_m2792,iECs_1301.ECs3430,iEKO11_1354.EKO11_1169,iEcDH1_1363.EcDH1_1104,iEcE24377_1341.EcE24377A_2850,iEcHS_1320.EcHS_A2719,iEcolC_1368.EcolC_1113,iG2583_1286.G2583_3145,iJO1366.b2564,iJR904.b2564,iWFL_1372.ECW_m2792,iY75_1357.Y75_RS13390	Bacteria	1MU9W@1224,1RMS5@1236,3XP85@561,COG0854@1,COG0854@2	NA|NA|NA	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C1_00584	198214.SF2625	4.5e-64	250.4	Gammaproteobacteria	acpS	GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008897,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016780,GO:0018070,GO:0018193,GO:0018209,GO:0018215,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901576	2.7.8.7,3.2.1.52	ko:K00997,ko:K01207	ko00520,ko00531,ko00770,ko01100,ko01501,map00520,map00531,map00770,map01100,map01501	M00628	R00022,R01625,R05963,R07809,R07810,R10831	RC00002,RC00049	ko00000,ko00001,ko00002,ko01000				Bacteria	1MZBF@1224,1S98P@1236,COG0736@1,COG0736@2	NA|NA|NA	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
C1_00585	316407.85675453	1.3e-46	191.8	Escherichia	yfhL			ko:K03522,ko:K05337					ko00000,ko04147				Bacteria	1MZ6H@1224,1S8ZV@1236,3XQ28@561,COG1145@1,COG1145@2	NA|NA|NA	C	4 iron, 4 sulfur cluster binding
C1_00586	155864.EDL933_3726	6e-149	533.5	Escherichia	yfhH	GO:0003674,GO:0003700,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141		ko:K15835,ko:K19337					ko00000,ko03000				Bacteria	1ND5W@1224,1RNCI@1236,3XNB2@561,COG1737@1,COG1737@2	NA|NA|NA	K	Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator
C1_00587	316407.85675451	1.7e-119	435.3	Escherichia	yfhB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008962,GO:0009058,GO:0009987,GO:0016020,GO:0016021,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0031224,GO:0031226,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576	3.1.3.27	ko:K18697	ko00564,map00564		R02029	RC00017	ko00000,ko00001,ko01000				Bacteria	1MWA9@1224,1RXX9@1236,3XM5U@561,COG0560@1,COG0560@2	NA|NA|NA	E	phosphatidylglycerophosphatase activity
C1_00588	469008.B21_02417	2.6e-91	341.3	Escherichia	tadA	GO:0002097,GO:0002100,GO:0003674,GO:0003824,GO:0004000,GO:0005488,GO:0006139,GO:0006382,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008251,GO:0008270,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016553,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0034470,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0052717,GO:0071704,GO:0090304,GO:1901360	3.4.17.13,3.5.4.1,3.5.4.3,3.5.4.33,3.8.1.5	ko:K01297,ko:K01485,ko:K01487,ko:K01563,ko:K11991	ko00230,ko00240,ko00330,ko00361,ko00625,ko01100,ko01120,map00230,map00240,map00330,map00361,map00625,map01100,map01120		R00974,R01411,R01676,R02922,R05284,R05367,R05368,R05369,R05370,R07669,R07670,R10223	RC00074,RC00204,RC00477,RC00514,RC00809,RC01317,RC01340,RC01341,RC02013	ko00000,ko00001,ko01000,ko01002,ko01011,ko03016				Bacteria	1RGU0@1224,1S60Z@1236,3XPNE@561,COG0590@1,COG0590@2	NA|NA|NA	F	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
C1_00589	362663.ECP_2560	2.7e-296	1023.8	Escherichia	mltF	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008933,GO:0009056,GO:0009057,GO:0009253,GO:0009279,GO:0016020,GO:0016740,GO:0016757,GO:0019867,GO:0030203,GO:0030312,GO:0030313,GO:0031975,GO:0043170,GO:0044462,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575		ko:K18691					ko00000,ko01000,ko01011			iBWG_1329.BWG_2322,iEC042_1314.EC042_2762,iECDH1ME8569_1439.ECDH1ME8569_2485,iECNA114_1301.ECNA114_2631,iECP_1309.ECP_2560,iECSF_1327.ECSF_2397,iECW_1372.ECW_m2786,iEKO11_1354.EKO11_1175,iEcDH1_1363.EcDH1_1110,iEcHS_1320.EcHS_A2711,iEcolC_1368.EcolC_1119,iG2583_1286.G2583_3089,iJO1366.b2558,iSFxv_1172.SFxv_2861,iUMN146_1321.UM146_03930,iUMNK88_1353.UMNK88_3212,iUTI89_1310.UTI89_C2878,iWFL_1372.ECW_m2786,iY75_1357.Y75_RS13345	Bacteria	1MWDS@1224,1RM8W@1236,3XMKR@561,COG4623@1,COG4623@2	NA|NA|NA	M	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella
C1_00590	155864.EDL933_3722	0.0	2582.4	Escherichia	purL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006520,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016884,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000			iECH74115_1262.ECH74115_3792,iECO111_1330.ECO111_3283,iECSP_1301.ECSP_3501,iECs_1301.ECs3423,iG2583_1286.G2583_3088,iJN746.PP_1037,ic_1306.c3080	Bacteria	1MYN4@1224,1RMRN@1236,3XP1B@561,COG0046@1,COG0046@2,COG0047@1,COG0047@2	NA|NA|NA	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate
C1_00591	199310.c3079	2.2e-241	841.3	Escherichia													Bacteria	1N58A@1224,1RP34@1236,3XPCT@561,COG0642@1,COG2205@2	NA|NA|NA	T	PhoQ Sensor
C1_00592	198214.SF2602	5.8e-129	466.8	Gammaproteobacteria	yfhG			ko:K02487,ko:K18138	ko01501,ko01503,ko02020,map01501,map01503,map02020	M00507,M00647,M00699,M00718			ko00000,ko00001,ko00002,ko01504,ko02000,ko02022,ko02035	2.A.6.2			Bacteria	1RDX1@1224,1S4CU@1236,COG3170@1,COG3170@2	NA|NA|NA	NU	YfhG lipoprotein
C1_00593	155864.EDL933_3719	9.8e-247	859.0	Escherichia	yfhA	GO:0000156,GO:0000160,GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001130,GO:0001150,GO:0001151,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0023052,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035326,GO:0035556,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060089,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141		ko:K07715	ko02020,ko02024,map02020,map02024	M00502			ko00000,ko00001,ko00002,ko02022				Bacteria	1MU0N@1224,1RMCK@1236,3XNKS@561,COG2204@1,COG2204@2	NA|NA|NA	K	Member of the two-component regulatory system GlrR GlrK that up-regulates transcription of the glmY sRNA when cells enter the stationary growth phase. Regulates glmY transcription by binding to three conserved sites in the purL-glmY intergenic region
C1_00594	1197719.A464_2673	7.6e-55	219.5	Salmonella	glnB	GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006808,GO:0008144,GO:0008150,GO:0009889,GO:0010565,GO:0017076,GO:0019216,GO:0019217,GO:0019222,GO:0030234,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042304,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0046890,GO:0050789,GO:0050790,GO:0050794,GO:0062012,GO:0065007,GO:0065009,GO:0080090,GO:0097159,GO:0097367,GO:0098772,GO:1901265,GO:1901363		ko:K04751,ko:K04752	ko02020,map02020				ko00000,ko00001				Bacteria	1RGWK@1224,1S67I@1236,3ZMCB@590,COG0347@1,COG0347@2	NA|NA|NA	K	Nitrogen regulatory protein P-II
C1_00595	155864.EDL933_3717	1.2e-232	812.0	Escherichia	hmp	GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0004155,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0008150,GO:0008152,GO:0008289,GO:0008941,GO:0009056,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016667,GO:0016671,GO:0016705,GO:0016708,GO:0017144,GO:0019725,GO:0020037,GO:0030003,GO:0031406,GO:0032843,GO:0033293,GO:0033554,GO:0034641,GO:0036094,GO:0042133,GO:0042135,GO:0042592,GO:0042737,GO:0043167,GO:0043168,GO:0043177,GO:0044237,GO:0044248,GO:0044270,GO:0044424,GO:0044464,GO:0046209,GO:0046210,GO:0046906,GO:0046916,GO:0048037,GO:0048878,GO:0050660,GO:0050662,GO:0050801,GO:0050896,GO:0051213,GO:0051409,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0071500,GO:0071949,GO:0072593,GO:0097159,GO:0098771,GO:1901265,GO:1901363,GO:2001057	1.14.12.17	ko:K05916	ko05132,map05132				ko00000,ko00001,ko01000			iECP_1309.ECP_2554	Bacteria	1MV41@1224,1RMPJ@1236,3XPAT@561,COG1017@1,COG1017@2,COG1018@1,COG1018@2	NA|NA|NA	C	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1_00596	1440052.EAKF1_ch3453	1.9e-239	834.7	Escherichia	glyA	GO:0001505,GO:0003674,GO:0003824,GO:0004372,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006546,GO:0006563,GO:0006565,GO:0006730,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009069,GO:0009070,GO:0009071,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016741,GO:0016742,GO:0017144,GO:0019264,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042133,GO:0042135,GO:0042136,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000			iG2583_1286.G2583_3081,iIT341.HP0183	Bacteria	1MUIS@1224,1RMHQ@1236,3XN0E@561,COG0112@1,COG0112@2	NA|NA|NA	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C1_00597	316407.85675445	8.5e-234	815.8	Escherichia	yphH		2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000				Bacteria	1NFKM@1224,1RMWQ@1236,3XPFW@561,COG1940@1,COG1940@2	NA|NA|NA	K	ROK family
C1_00598	316407.85675444	0.0	2255.3	Escherichia													Bacteria	1Q3TC@1224,1RRC8@1236,3XP8A@561,COG0457@1,COG0457@2	NA|NA|NA	S	Domain of unknown function (DUF5107)
C1_00599	155864.EDL933_3712	2.7e-177	627.9	Escherichia	yphF			ko:K02058,ko:K10439	ko02010,ko02030,map02010,map02030	M00212,M00221			ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19			Bacteria	1PCD4@1224,1RPZE@1236,3XNDR@561,COG1879@1,COG1879@2	NA|NA|NA	G	ABC transporter
C1_00600	316407.1799964	1.9e-278	964.5	Escherichia	yphE		3.6.3.17	ko:K02056,ko:K10441	ko02010,map02010	M00212,M00221			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19			Bacteria	1MU22@1224,1S1ND@1236,3XNWJ@561,COG1129@1,COG1129@2	NA|NA|NA	P	ABC transporter, ATP-binding protein
C1_00601	481805.EcolC_1131	1e-155	556.2	Gammaproteobacteria	yphD	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015749,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034219,GO:0044425,GO:0044459,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944		ko:K02057,ko:K10440	ko02010,map02010	M00212,M00221			ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19			Bacteria	1PSTG@1224,1RSQZ@1236,COG1172@1,COG1172@2	NA|NA|NA	G	the binding-protein-dependent transport system
C1_00602	481805.EcolC_1132	3.6e-207	727.2	Escherichia	yphC		1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220		R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000			iECW_1372.ECW_m2771,iWFL_1372.ECW_m2771	Bacteria	1MV9A@1224,1S0CK@1236,3XPEW@561,COG1063@1,COG1063@2	NA|NA|NA	E	zinc ion binding
C1_00603	316407.85675442	6.3e-178	629.8	Escherichia	yphB	GO:0003674,GO:0003824,GO:0004034,GO:0005975,GO:0005996,GO:0006006,GO:0006012,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019318,GO:0019320,GO:0019388,GO:0033499,GO:0033554,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0050896,GO:0051716,GO:0071704,GO:1901575	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000				Bacteria	1RAQE@1224,1S03U@1236,3XP7P@561,COG2017@1,COG2017@2	NA|NA|NA	G	aldose 1-epimerase activity
C1_00604	198214.SF2590	8e-70	269.6	Gammaproteobacteria	yphA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K15977					ko00000				Bacteria	1RBM0@1224,1T00T@1236,COG2259@1,COG2259@2	NA|NA|NA	S	SURF4 family
C1_00605	316407.1799960	2.1e-227	794.7	Gammaproteobacteria	hcaD	GO:0000166,GO:0000302,GO:0001505,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006725,GO:0006805,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009410,GO:0009987,GO:0010035,GO:0015044,GO:0016054,GO:0016491,GO:0016730,GO:0016731,GO:0016999,GO:0017001,GO:0017144,GO:0018962,GO:0019380,GO:0019439,GO:0019752,GO:0032787,GO:0033554,GO:0034599,GO:0034614,GO:0034641,GO:0035690,GO:0036094,GO:0042133,GO:0042135,GO:0042178,GO:0042221,GO:0042493,GO:0042537,GO:0042737,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046209,GO:0046210,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071241,GO:0071466,GO:0071704,GO:0071731,GO:0071732,GO:0072329,GO:0072593,GO:0097159,GO:0097366,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:2001057	1.18.1.3,1.7.1.15	ko:K00362,ko:K00529,ko:K12265	ko00071,ko00360,ko00910,ko01120,ko01220,ko05132,map00071,map00360,map00910,map01120,map01220,map05132	M00530,M00545	R00787,R02000,R06782,R06783	RC00098,RC00176	br01602,ko00000,ko00001,ko00002,ko01000			iECSP_1301.ECSP_3486,iECs_1301.ECs3408,iEcHS_1320.EcHS_A2847,iSFxv_1172.SFxv_2845,iZ_1308.Z3814	Bacteria	1NR3M@1224,1RN6P@1236,COG0446@1,COG0446@2	NA|NA|NA	P	pyridine nucleotide-disulphide oxidoreductase
C1_00606	469008.B21_02397	5.2e-150	537.0	Gammaproteobacteria													Bacteria	1N32I@1224,1RRJG@1236,COG1028@1,COG1028@2	NA|NA|NA	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family
C1_00607	198214.SF2587	5.9e-57	226.5	Gammaproteobacteria	hcaC	GO:0003674,GO:0005488,GO:0006082,GO:0006725,GO:0006805,GO:0008150,GO:0008152,GO:0009056,GO:0009410,GO:0009987,GO:0016054,GO:0016999,GO:0017001,GO:0017144,GO:0018962,GO:0019380,GO:0019439,GO:0019752,GO:0032787,GO:0042178,GO:0042221,GO:0042537,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050896,GO:0051536,GO:0051537,GO:0051540,GO:0051716,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:1901360,GO:1901361,GO:1901575	1.7.1.15	ko:K00363,ko:K05710	ko00360,ko00910,ko01120,ko01220,map00360,map00910,map01120,map01220	M00530,M00545	R00787,R06782,R06783	RC00098,RC00176	br01602,ko00000,ko00001,ko00002,ko01000			iEC55989_1330.EC55989_3772	Bacteria	1N8PE@1224,1S6B0@1236,COG2146@1,COG2146@2	NA|NA|NA	P	Part of the multicomponent 3-phenylpropionate dioxygenase, that converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP- dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively. This protein seems to be a 2Fe-2S ferredoxin
C1_00608	316407.1799957	1.2e-94	352.4	Gammaproteobacteria	hcaF	GO:0006082,GO:0006725,GO:0006805,GO:0008150,GO:0008152,GO:0009056,GO:0009410,GO:0009987,GO:0016054,GO:0016999,GO:0017001,GO:0017144,GO:0018962,GO:0019380,GO:0019439,GO:0019752,GO:0032787,GO:0042178,GO:0042221,GO:0042537,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0050896,GO:0051716,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:1901360,GO:1901361,GO:1901575	1.14.12.19	ko:K05709	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002,ko01000			iEC042_1314.EC042_2743	Bacteria	1RANS@1224,1T1EB@1236,COG5517@1,COG5517@2	NA|NA|NA	Q	Part of the multicomponent 3-phenylpropionate dioxygenase. Converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively
C1_00609	155864.EDL933_3701	1.3e-278	964.9	Gammaproteobacteria	hcaE	GO:0006082,GO:0006725,GO:0006805,GO:0008150,GO:0008152,GO:0009056,GO:0009410,GO:0009987,GO:0016054,GO:0016999,GO:0017001,GO:0017144,GO:0018962,GO:0019380,GO:0019439,GO:0019752,GO:0032787,GO:0042178,GO:0042221,GO:0042537,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0050896,GO:0051716,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:1901360,GO:1901361,GO:1901575	1.14.12.19	ko:K05708	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002,ko01000			iSFV_1184.SFV_2586	Bacteria	1N6MJ@1224,1RNCN@1236,COG4638@1,COG4638@2	NA|NA|NA	P	Part of the multicomponent 3-phenylpropionate dioxygenase. Converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively
C1_00610	155864.EDL933_3700	5e-162	577.0	Escherichia	hcaR	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141		ko:K05817					ko00000,ko03000				Bacteria	1Q8UG@1224,1S05A@1236,3XRJD@561,COG0583@1,COG0583@2	NA|NA|NA	K	transcriptional activator of
C1_00611	316407.1799945	2.7e-205	721.1	Escherichia	hcaT	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015893,GO:0016020,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944	1.5.1.2	ko:K00286,ko:K05820,ko:K08161	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.1.2.20,2.A.1.27		iECIAI39_1322.ECIAI39_2737,iEcSMS35_1347.EcSMS35_2688,iSFV_1184.SFV_2584,iSF_1195.SF2583,iS_1188.S2755	Bacteria	1MVZI@1224,1RPBT@1236,3XMD3@561,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
C1_00612	199310.c3061	1.5e-244	851.7	Escherichia	csiE												Bacteria	1NFZH@1224,1RN8B@1236,3XMR7@561,COG3711@1,COG3711@2	NA|NA|NA	K	regulation of nucleic acid-templated transcription
C1_00613	469008.B21_02390	1.5e-163	582.0	Escherichia	yfhR			ko:K06889					ko00000				Bacteria	1RFAF@1224,1S2YT@1236,3XPC6@561,COG1073@1,COG1073@2	NA|NA|NA	S	Prolyl oligopeptidase family
C1_00614	155864.EDL933_3696	2.2e-148	531.6	Escherichia	suhB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0031403,GO:0031420,GO:0042578,GO:0043167,GO:0043169,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0046872,GO:0047954,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000			iECP_1309.ECP_2538,iPC815.YPO2899	Bacteria	1MUQT@1224,1RNME@1236,3XNR1@561,COG0483@1,COG0483@2	NA|NA|NA	G	inositol metabolic process
C1_00615	155864.EDL933_3695	7.3e-135	486.5	Escherichia	trmJ	GO:0001510,GO:0002128,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.200,3.5.1.19,6.1.1.16	ko:K01883,ko:K02533,ko:K08281,ko:K15396	ko00760,ko00970,ko01100,map00760,map00970,map01100	M00359,M00360	R01268,R03650	RC00055,RC00100,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016				Bacteria	1N47Y@1224,1RPD3@1236,3XN2I@561,COG0565@1,COG0565@2	NA|NA|NA	J	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C1_00616	481805.EcolC_1146	1e-84	319.3	Escherichia	iscR	GO:0003674,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141	2.8.1.7	ko:K04487,ko:K13643	ko00730,ko01100,ko04122,map00730,map01100,map04122		R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03000,ko03016,ko03029				Bacteria	1RDA4@1224,1S3RW@1236,3XPCG@561,COG1959@1,COG1959@2	NA|NA|NA	K	Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins
C1_00617	1440052.EAKF1_ch3469	5.8e-230	803.1	Escherichia	iscS	GO:0001522,GO:0003674,GO:0003824,GO:0004123,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006790,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009000,GO:0009058,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016226,GO:0016740,GO:0016769,GO:0016782,GO:0016783,GO:0016829,GO:0016846,GO:0018130,GO:0018131,GO:0019842,GO:0022607,GO:0030170,GO:0031071,GO:0031119,GO:0031163,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046484,GO:0048037,GO:0050662,GO:0051186,GO:0070279,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097163,GO:0140104,GO:1901360,GO:1901363	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122		R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029			iPC815.YPO2896,iYL1228.KPN_02862	Bacteria	1MU1C@1224,1RNCD@1236,3XMZ0@561,COG1104@1,COG1104@2	NA|NA|NA	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. Also functions as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate
C1_00618	155864.EDL933_3692	1.9e-65	255.0	Escherichia	iscU	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016043,GO:0016226,GO:0016740,GO:0016782,GO:0019538,GO:0019725,GO:0022607,GO:0030003,GO:0031163,GO:0036455,GO:0042592,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0071840,GO:0097428,GO:0098771,GO:1901564		ko:K04488					ko00000			iAPECO1_1312.APECO1_3996,iB21_1397.B21_02385,iBWG_1329.BWG_2293,iE2348C_1286.E2348C_2812,iEC042_1314.EC042_2733,iEC55989_1330.EC55989_2814,iECABU_c1320.ECABU_c28350,iECBD_1354.ECBD_1155,iECB_1328.ECB_02421,iECDH10B_1368.ECDH10B_2696,iECDH1ME8569_1439.ECDH1ME8569_2456,iECD_1391.ECD_02421,iECED1_1282.ECED1_2960,iECH74115_1262.ECH74115_3761,iECIAI1_1343.ECIAI1_2581,iECIAI39_1322.ECIAI39_2730,iECNA114_1301.ECNA114_2608,iECO103_1326.ECO103_3046,iECO111_1330.ECO111_3253,iECO26_1355.ECO26_3576,iECOK1_1307.ECOK1_2878,iECP_1309.ECP_2534,iECS88_1305.ECS88_2705,iECSE_1348.ECSE_2815,iECSF_1327.ECSF_2373,iECSP_1301.ECSP_3473,iECUMN_1333.ECUMN_2849,iECW_1372.ECW_m2755,iECs_1301.ECs3395,iEKO11_1354.EKO11_1204,iETEC_1333.ETEC_2686,iEcDH1_1363.EcDH1_1139,iEcE24377_1341.EcE24377A_2814,iEcHS_1320.EcHS_A2680,iEcSMS35_1347.EcSMS35_2682,iEcolC_1368.EcolC_1148,iG2583_1286.G2583_3059,iJO1366.b2529,iSDY_1059.SDY_2725,iSFV_1184.SFV_2577,iSF_1195.SF2576,iSFxv_1172.SFxv_2832,iSSON_1240.SSON_2611,iS_1188.S2748,iUMN146_1321.UM146_04055,iUMNK88_1353.UMNK88_3182,iUTI89_1310.UTI89_C2851,iWFL_1372.ECW_m2755,iY75_1357.Y75_RS13200,iZ_1308.Z3796,ic_1306.c3055	Bacteria	1RD5K@1224,1S3P1@1236,3XPIY@561,COG0822@1,COG0822@2	NA|NA|NA	C	It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters
C1_00619	1440052.EAKF1_ch3471	5.6e-55	219.9	Escherichia	iscA	GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016043,GO:0016226,GO:0016530,GO:0019538,GO:0022607,GO:0031163,GO:0034986,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051540,GO:0051604,GO:0071704,GO:0071840,GO:0097428,GO:0140104,GO:1901564		ko:K05997,ko:K13628					ko00000,ko03016			iAPECO1_1312.APECO1_3997,iB21_1397.B21_02384,iBWG_1329.BWG_2292,iE2348C_1286.E2348C_2811,iEC042_1314.EC042_2732,iEC55989_1330.EC55989_2813,iECABU_c1320.ECABU_c28340,iECBD_1354.ECBD_1156,iECB_1328.ECB_02420,iECDH10B_1368.ECDH10B_2695,iECD_1391.ECD_02420,iECED1_1282.ECED1_2959,iECIAI1_1343.ECIAI1_2580,iECIAI39_1322.ECIAI39_2729,iECNA114_1301.ECNA114_2607,iECO103_1326.ECO103_3045,iECO111_1330.ECO111_3252,iECO26_1355.ECO26_3575,iECOK1_1307.ECOK1_2877,iECP_1309.ECP_2533,iECS88_1305.ECS88_2704,iECSE_1348.ECSE_2814,iECSF_1327.ECSF_2372,iECSP_1301.ECSP_3472,iECUMN_1333.ECUMN_2848,iECW_1372.ECW_m2754,iECs_1301.ECs3394,iEKO11_1354.EKO11_1205,iETEC_1333.ETEC_2685,iEcDH1_1363.EcDH1_1140,iEcSMS35_1347.EcSMS35_2681,iEcolC_1368.EcolC_1149,iG2583_1286.G2583_3058,iJO1366.b2528,iLF82_1304.LF82_1120,iNRG857_1313.NRG857_12580,iSBO_1134.SBO_2552,iSDY_1059.SDY_2724,iSF_1195.SF2575,iSSON_1240.SSON_2610,iS_1188.S2747,iUMN146_1321.UM146_04060,iUMNK88_1353.UMNK88_3181,iWFL_1372.ECW_m2754,iY75_1357.Y75_RS13195,iZ_1308.Z3795,ic_1306.c3053	Bacteria	1RH6T@1224,1S5XD@1236,3XPP7@561,COG0316@1,COG0316@2	NA|NA|NA	S	Is able to transfer iron-sulfur clusters to apo- ferredoxin. Multiple cycles of 2Fe2S cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA TrxB
C1_00620	155864.EDL933_3689	6.1e-88	330.1	Escherichia	hscB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051604,GO:0071704,GO:0097428,GO:1901564,GO:1902494,GO:1990230,GO:1990234		ko:K04082,ko:K05801					ko00000,ko03029,ko03110				Bacteria	1RHZX@1224,1S9YH@1236,3XMB5@561,COG1076@1,COG1076@2	NA|NA|NA	O	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C1_00621	155864.EDL933_3688	0.0	1156.4	Escherichia	hscA	GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006807,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010467,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0019538,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051604,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070417,GO:0070887,GO:0071310,GO:0071704,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0097428,GO:0140110,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1903506,GO:1990230,GO:1990234,GO:2001141		ko:K04043,ko:K04044	ko03018,ko04212,ko05152,map03018,map04212,map05152				ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33,1.A.33.1			Bacteria	1MVQI@1224,1RN74@1236,3XMUN@561,COG0443@1,COG0443@2	NA|NA|NA	O	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU
C1_00622	155864.EDL933_3687	8.6e-59	232.6	Escherichia	fdx	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006790,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016043,GO:0016226,GO:0016491,GO:0022607,GO:0022900,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051540,GO:0055114,GO:0071840		ko:K04755					ko00000				Bacteria	1RHDC@1224,1S5XW@1236,3XPTK@561,COG0633@1,COG0633@2	NA|NA|NA	C	that it has a role as a cellular electron transfer protein. Involved in the in vivo assembly of the Fe-S clusters in a wide variety of iron- sulfur proteins
C1_00623	155864.EDL933_3686	7e-32	142.5	Escherichia	iscX	GO:0003674,GO:0004857,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0030234,GO:0031163,GO:0043086,GO:0043167,GO:0043169,GO:0044085,GO:0044092,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050790,GO:0051186,GO:0065007,GO:0065009,GO:0071840,GO:0098772											Bacteria	1N7C1@1224,1SC9F@1236,3XPZ5@561,COG2975@1,COG2975@2	NA|NA|NA	S	May function as iron donor in the assembly of iron- sulfur clusters
C1_00624	469008.B21_02379	1.2e-246	858.6	Escherichia	pepB	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009056,GO:0009987,GO:0016787,GO:0019538,GO:0034641,GO:0042802,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575	3.4.11.1,3.4.11.23	ko:K01255,ko:K07751	ko00480,ko01100,map00480,map01100		R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002			iAF1260.b2523,iBWG_1329.BWG_2287,iECDH10B_1368.ECDH10B_2690,iECDH1ME8569_1439.ECDH1ME8569_2450,iEcDH1_1363.EcDH1_1145,iJO1366.b2523,iY75_1357.Y75_RS13170	Bacteria	1MUIN@1224,1RNFI@1236,3XPE7@561,COG0260@1,COG0260@2	NA|NA|NA	E	Probably plays an important role in intracellular peptide degradation
C1_00625	198214.SF2569	5.5e-141	506.9	Gammaproteobacteria	sseB												Bacteria	1R4DR@1224,1RRDT@1236,28I6Y@1,2Z89T@2	NA|NA|NA	S	enhanced serine sensitivity protein SseB
C1_00626	316407.85675438	4.7e-162	577.0	Escherichia	sseA	GO:0003674,GO:0003824,GO:0004792,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009605,GO:0009987,GO:0009991,GO:0016740,GO:0016782,GO:0016783,GO:0016784,GO:0031668,GO:0033554,GO:0034641,GO:0042221,GO:0042262,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122		R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000			iECs_1301.ECs3387,iZ_1308.Z3788	Bacteria	1MW4B@1224,1RSQ3@1236,3XMB1@561,COG2897@1,COG2897@2	NA|NA|NA	P	Its participation in detoxification of cyanide may be small. May be involved in the enhancement of serine sensitivity
C1_00627	316407.85675437	0.0	3250.3	Escherichia	yfhM	GO:0003674,GO:0004857,GO:0004866,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009892,GO:0009897,GO:0009986,GO:0010466,GO:0010605,GO:0010951,GO:0016020,GO:0019222,GO:0030162,GO:0030234,GO:0030414,GO:0031224,GO:0031225,GO:0031226,GO:0031233,GO:0031323,GO:0031324,GO:0031362,GO:0032268,GO:0032269,GO:0043086,GO:0044092,GO:0044425,GO:0044459,GO:0044464,GO:0045861,GO:0046658,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051336,GO:0051346,GO:0052547,GO:0052548,GO:0060255,GO:0061134,GO:0061135,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0098552,GO:0098772		ko:K06894					ko00000				Bacteria	1MV7J@1224,1RNRY@1236,3XN1J@561,COG2373@1,COG2373@2	NA|NA|NA	S	peptidase regulator activity
C1_00628	316407.85675436	0.0	1570.4	Escherichia	pbpC	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0008144,GO:0008150,GO:0008658,GO:0008955,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0031224,GO:0031406,GO:0033218,GO:0033293,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0044425,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051302,GO:0051781,GO:0065007,GO:0097159,GO:1901363,GO:1901681	2.4.1.129	ko:K05367	ko00550,map00550				ko00000,ko00001,ko01000,ko01003,ko01011		GT51	iE2348C_1286.E2348C_2802,iECO111_1330.ECO111_3243,iSF_1195.SF2565	Bacteria	1MUA9@1224,1RMBV@1236,3XMHY@561,COG4953@1,COG4953@2	NA|NA|NA	M	penicillin-binding protein 1C
C1_00629	155864.EDL933_3675	1.1e-74	285.8	Escherichia	ndk	GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131				Bacteria	1R9ZA@1224,1S1Z3@1236,3XPKC@561,COG0105@1,COG0105@2	NA|NA|NA	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
C1_00630	316407.1799916	5.2e-220	770.0	Escherichia	rlmN	GO:0000049,GO:0000154,GO:0001510,GO:0002935,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016426,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0070040,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:0140102,GO:1901360,GO:1901363	2.1.1.192	ko:K06941					ko00000,ko01000,ko03009				Bacteria	1MUYK@1224,1RMUI@1236,3XMG3@561,COG0820@1,COG0820@2	NA|NA|NA	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
C1_00631	198214.SF2562	5e-142	510.8	Gammaproteobacteria	rodZ	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008360,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944		ko:K15539					ko00000				Bacteria	1N240@1224,1RQMV@1236,COG1426@1,COG1426@2	NA|NA|NA	S	Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis
C1_00632	155864.EDL933_3672	7.3e-203	713.0	Escherichia	ispG	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009055,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0022900,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046429,GO:0046490,GO:0046872,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000			iAF1260.b2515,iAPECO1_1312.APECO1_4009,iB21_1397.B21_02369,iBWG_1329.BWG_2279,iE2348C_1286.E2348C_2798,iEC55989_1330.EC55989_2800,iECABU_c1320.ECABU_c28200,iECBD_1354.ECBD_1171,iECB_1328.ECB_02407,iECDH10B_1368.ECDH10B_2681,iECDH1ME8569_1439.ECDH1ME8569_2442,iECDH1ME8569_1439.EcDH1_1153,iECD_1391.ECD_02407,iECED1_1282.ECED1_2946,iECH74115_1262.ECH74115_3740,iECIAI39_1322.ECIAI39_2716,iECNA114_1301.ECNA114_2593,iECO103_1326.ECO103_3032,iECO111_1330.ECO111_3239,iECO26_1355.ECO26_3562,iECOK1_1307.ECOK1_2863,iECP_1309.ECP_2520,iECS88_1305.ECS88_2691,iECSE_1348.ECSE_2801,iECSF_1327.ECSF_2359,iECSP_1301.ECSP_3455,iECW_1372.ECW_m2740,iECs_1301.ECs3377,iEKO11_1354.EKO11_1218,iETEC_1333.ETEC_2672,iEcDH1_1363.EcDH1_1153,iEcE24377_1341.EcE24377A_2799,iEcolC_1368.EcolC_1162,iHN637.CLJU_RS06430,iIT341.HP0625,iJN678.gcpE,iJO1366.b2515,iJR904.b2515,iLF82_1304.LF82_1130,iNRG857_1313.NRG857_12515,iUMN146_1321.UM146_04130,iUMNK88_1353.UMNK88_3165,iUTI89_1310.UTI89_C2836,iWFL_1372.ECW_m2740,iY75_1357.Y75_RS13130,iYL1228.KPN_02845,iZ_1308.Z3778,ic_1306.c3037	Bacteria	1MUAX@1224,1RMXZ@1236,3XPHC@561,COG0821@1,COG0821@2	NA|NA|NA	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C1_00633	155864.EDL933_3671	3.3e-244	850.5	Escherichia	hisS	GO:0003674,GO:0003824,GO:0004812,GO:0004821,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006427,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iE2348C_1286.E2348C_2797,iECNA114_1301.ECNA114_2592,iECSF_1327.ECSF_2358	Bacteria	1MV2K@1224,1RPHI@1236,3XMFB@561,COG0124@1,COG0124@2	NA|NA|NA	J	histidyl-tRNA aminoacylation
C1_00634	316407.85675434	4.6e-106	390.6	Escherichia	yfgM	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031233,GO:0044425,GO:0044459,GO:0044464,GO:0071575,GO:0071944,GO:0098552											Bacteria	1N117@1224,1S95P@1236,3XMCB@561,COG2976@1,COG2976@2	NA|NA|NA	S	Tetratricopeptide repeat-like domain
C1_00635	469008.B21_02366	2.9e-202	711.1	Escherichia	bamB	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0008152,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0016491,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0042802,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0055114,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063		ko:K17713					ko00000,ko02000	1.B.33.1			Bacteria	1MXIJ@1224,1RN4V@1236,3XN9I@561,COG1520@1,COG1520@2	NA|NA|NA	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1_00636	155864.EDL933_3668	3.8e-276	956.8	Escherichia	der	GO:0000027,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022607,GO:0022613,GO:0022618,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032794,GO:0034622,GO:0035639,GO:0036094,GO:0042254,GO:0042255,GO:0042273,GO:0043021,GO:0043022,GO:0043023,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363		ko:K03977					ko00000,ko03009				Bacteria	1MU9S@1224,1RMSF@1236,3XPBZ@561,COG1160@1,COG1160@2	NA|NA|NA	J	GTPase that plays an essential role in the late steps of ribosome biogenesis
C1_00637	198214.SF2556	3.3e-35	153.7	Gammaproteobacteria	yfgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588											Bacteria	1N9D9@1224,1SCH3@1236,COG1645@1,COG1645@2	NA|NA|NA	S	bacterial-type flagellum-dependent swarming motility
C1_00638	316407.1805569	3.3e-213	747.7	Escherichia	xseA	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494	3.1.11.6	ko:K03601	ko03430,map03430				ko00000,ko00001,ko01000,ko03400				Bacteria	1MUA4@1224,1RNAZ@1236,3XM63@561,COG1570@1,COG1570@2	NA|NA|NA	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
C1_00639	1440052.EAKF1_ch3495c	2.7e-266	924.1	Escherichia	guaB	GO:0003674,GO:0003824,GO:0003938,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147			iAPECO1_1312.APECO1_4018,iECABU_c1320.ECABU_c28100,iECP_1309.ECP_2510,iECSF_1327.ECSF_2349,iUTI89_1310.UTI89_C2826,ic_1306.c3027	Bacteria	1MUJM@1224,1RMT8@1236,3XNH9@561,COG0516@1,COG0516@2,COG0517@1,COG0517@2	NA|NA|NA	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
C1_00640	155864.EDL933_3664	1.7e-309	1067.8	Escherichia	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002			iJN746.PP_1032,iLJ478.TM1820,iSF_1195.SF2553,iSFxv_1172.SFxv_2808,iS_1188.S2725,iYL1228.KPN_02833	Bacteria	1MU2A@1224,1RP81@1236,3XNP3@561,COG0518@1,COG0518@2,COG0519@1,COG0519@2	NA|NA|NA	F	Catalyzes the synthesis of GMP from XMP
C1_00641	155864.EDL933_3663	1.3e-69	269.2	Escherichia	yfgI	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716											Bacteria	1RJM9@1224,1S7QM@1236,2AQ7C@1,31FD2@2,3XNKB@561	NA|NA|NA	S	cellular response to DNA damage stimulus
C1_00642	155864.EDL933_3662	1.6e-64	252.3	Escherichia	yfgH	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944		ko:K06077					ko00000				Bacteria	1RFYG@1224,1S4YR@1236,3XNPC@561,COG3133@1,COG3133@2	NA|NA|NA	M	Glycine zipper
C1_00643	1440052.EAKF1_ch3511c	5.1e-23	112.8	Escherichia	yfgG												Bacteria	1N7D5@1224,1SDVM@1236,2E49W@1,32Z5K@2,3XR8T@561	NA|NA|NA	S	Protein of unknown function (DUF2633)
C1_00645	316407.1805566	0.0	1458.7	Escherichia	yfgF	GO:0000302,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008081,GO:0008150,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0016020,GO:0016021,GO:0016787,GO:0016788,GO:0031224,GO:0033554,GO:0034059,GO:0034599,GO:0034614,GO:0035690,GO:0036293,GO:0036294,GO:0042221,GO:0042493,GO:0042542,GO:0042578,GO:0043900,GO:0044425,GO:0044464,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070301,GO:0070482,GO:0070887,GO:0071111,GO:0071236,GO:0071453,GO:0071454,GO:0071944,GO:0097237,GO:1900190,GO:1901700,GO:1901701											Bacteria	1N299@1224,1RN30@1236,3XMW8@561,COG2200@1,COG2200@2	NA|NA|NA	T	Truncated proteins consisting of the GGDEF EAL domains (residues 319-747) or of the EAL domain alone (481-747) have c-di- GMP phosphodiesterase activity. They do not have diguanylate cyclase activity. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria
C1_00646	155864.EDL933_3658	2.5e-294	1017.3	Escherichia	ppx	GO:0003674,GO:0003824,GO:0004309,GO:0005488,GO:0005515,GO:0006082,GO:0006793,GO:0006797,GO:0006798,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0042802,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0071704,GO:1901575	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230		R03409	RC00002	ko00000,ko00001,ko01000			iECABU_c1320.ECABU_c42590,iECED1_1282.ECED1_4463,iECIAI39_1322.ECIAI39_2643	Bacteria	1MV35@1224,1RN3V@1236,3XNC4@561,COG0248@1,COG0248@2	NA|NA|NA	FP	Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain
C1_00647	155864.EDL933_3657	0.0	1366.7	Escherichia	ppk	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006082,GO:0006091,GO:0006139,GO:0006163,GO:0006165,GO:0006464,GO:0006468,GO:0006725,GO:0006753,GO:0006757,GO:0006793,GO:0006796,GO:0006797,GO:0006799,GO:0006807,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009117,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009179,GO:0009185,GO:0009199,GO:0009205,GO:0009259,GO:0009279,GO:0009358,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016778,GO:0017144,GO:0019538,GO:0019637,GO:0019693,GO:0019867,GO:0030312,GO:0030313,GO:0031241,GO:0031975,GO:0032991,GO:0034641,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0043751,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044425,GO:0044462,GO:0044464,GO:0046031,GO:0046034,GO:0046483,GO:0046777,GO:0046939,GO:0055086,GO:0061695,GO:0071704,GO:0071944,GO:0072521,GO:0098552,GO:1901135,GO:1901360,GO:1901564,GO:1901576,GO:1902494,GO:1990234	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018				ko00000,ko00001,ko01000,ko03019			iSbBS512_1146.SbBS512_E2875	Bacteria	1MUM3@1224,1RNRX@1236,3XN1S@561,COG0855@1,COG0855@2	NA|NA|NA	F	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C1_00648	198214.SF2544	8.6e-116	422.9	Gammaproteobacteria	purN	GO:0003674,GO:0003824,GO:0004644,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000			iAF1260.b2500,iBWG_1329.BWG_2264,iECDH10B_1368.ECDH10B_2666,iECDH1ME8569_1439.ECDH1ME8569_2426,iEcDH1_1363.EcDH1_1169,iJO1366.b2500,iJR904.b2500,iY75_1357.Y75_RS13050	Bacteria	1MWN1@1224,1RMHS@1236,COG0299@1,COG0299@2	NA|NA|NA	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C1_00649	199310.c3017	6.6e-198	696.4	Escherichia	purM	GO:0003674,GO:0003824,GO:0004641,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.3.1,6.3.4.13	ko:K01933,ko:K11788	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04208	RC00090,RC00166,RC01100	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_1844,iECSF_1327.ECSF_2340	Bacteria	1MURG@1224,1RNZZ@1236,3XP9U@561,COG0150@1,COG0150@2	NA|NA|NA	F	Phosphoribosylformylglycinamidine cyclo-ligase
C1_00650	1440052.EAKF1_ch3521	2.6e-109	401.4	Escherichia	upp	GO:0003674,GO:0003824,GO:0004845,GO:0004849,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016763,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0042802,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100		R00966	RC00063	ko00000,ko00001,ko01000			iAF1260.b2498,iAPECO1_1312.APECO1_4071,iB21_1397.B21_02352,iBWG_1329.BWG_2262,iE2348C_1286.E2348C_2723,iEC042_1314.EC042_2699,iEC55989_1330.EC55989_2783,iECABU_c1320.ECABU_c27980,iECBD_1354.ECBD_1190,iECB_1328.ECB_02390,iECDH10B_1368.ECDH10B_2664,iECDH1ME8569_1439.ECDH1ME8569_2424,iECD_1391.ECD_02390,iECED1_1282.ECED1_2921,iECH74115_1262.ECH74115_3720,iECIAI1_1343.ECIAI1_2550,iECIAI39_1322.ECIAI39_2639,iECNA114_1301.ECNA114_2571,iECO103_1326.ECO103_3015,iECO111_1330.ECO111_3222,iECO26_1355.ECO26_3545,iECOK1_1307.ECOK1_2794,iECP_1309.ECP_2500,iECS88_1305.ECS88_2669,iECSE_1348.ECSE_2784,iECSF_1327.ECSF_2339,iECSP_1301.ECSP_3437,iECUMN_1333.ECUMN_2811,iECW_1372.ECW_m2721,iEKO11_1354.EKO11_1236,iETEC_1333.ETEC_2603,iEcDH1_1363.EcDH1_1171,iEcE24377_1341.EcE24377A_2781,iEcHS_1320.EcHS_A2633,iEcSMS35_1347.EcSMS35_2645,iEcolC_1368.EcolC_1178,iG2583_1286.G2583_3021,iJN746.PP_0746,iJO1366.b2498,iJR904.b2498,iLF82_1304.LF82_2383,iNRG857_1313.NRG857_12410,iSFV_1184.SFV_2543,iSF_1195.SF2542,iS_1188.S2691,iSbBS512_1146.SbBS512_E2872,iUMN146_1321.UM146_04235,iUMNK88_1353.UMNK88_3094,iWFL_1372.ECW_m2721,iY75_1357.Y75_RS13040,ic_1306.c3015	Bacteria	1MV4N@1224,1RPBG@1236,3XMQQ@561,COG0035@1,COG0035@2	NA|NA|NA	F	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C1_00651	316407.1805557	1.2e-225	788.9	Escherichia	uraA	GO:0003674,GO:0005215,GO:0005345,GO:0005350,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006206,GO:0006208,GO:0006212,GO:0006725,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006863,GO:0008150,GO:0008152,GO:0008324,GO:0008509,GO:0008514,GO:0009056,GO:0009112,GO:0009987,GO:0015075,GO:0015143,GO:0015205,GO:0015210,GO:0015238,GO:0015711,GO:0015747,GO:0015851,GO:0015855,GO:0015857,GO:0015893,GO:0016020,GO:0016021,GO:0017144,GO:0019860,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0034641,GO:0042221,GO:0042493,GO:0042737,GO:0042906,GO:0042907,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0072527,GO:0072529,GO:0072530,GO:0072531,GO:0098655,GO:0098656,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901702,GO:1903791,GO:1904082,GO:1904823		ko:K02824,ko:K09016,ko:K16345,ko:K16346					ko00000,ko02000	2.A.40.1.1,2.A.40.1.2,2.A.40.1.3,2.A.40.4.2,2.A.40.4.3		iECO103_1326.ECO103_1052,iG2583_1286.G2583_3536,iSDY_1059.SDY_4086,iSFxv_1172.SFxv_2795,iS_1188.S2690	Bacteria	1MUN9@1224,1RRK5@1236,3XMK3@561,COG2233@1,COG2233@2	NA|NA|NA	F	permease
C1_00652	155864.EDL933_3651	6.5e-139	500.0	Escherichia	hda	GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008156,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010556,GO:0010558,GO:0010605,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030174,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090329,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:2000104,GO:2000112,GO:2000113		ko:K02313,ko:K10763	ko02020,ko04112,map02020,map04112				ko00000,ko00001,ko03032,ko03036				Bacteria	1MVW6@1224,1RPJP@1236,3XNZA@561,COG0593@1,COG0593@2	NA|NA|NA	J	Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA
C1_00653	155864.EDL933_3650	4.2e-59	233.8	Escherichia	arsC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	1.20.4.1	ko:K00537					ko00000,ko01000				Bacteria	1MZ4Z@1224,1S8XH@1236,3XPP4@561,COG1393@1,COG1393@2	NA|NA|NA	P	oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor
C1_00654	198214.SF2538	7.7e-269	932.6	Gammaproteobacteria	bepA	GO:0003674,GO:0003756,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016043,GO:0016787,GO:0016853,GO:0016860,GO:0016864,GO:0019538,GO:0022607,GO:0030163,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043163,GO:0043165,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044091,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044464,GO:0045229,GO:0046872,GO:0051603,GO:0061024,GO:0061077,GO:0070011,GO:0071704,GO:0071709,GO:0071840,GO:0140096,GO:1901564,GO:1901565,GO:1901575											Bacteria	1MVFV@1224,1RP5S@1236,COG4783@1,COG4783@2	NA|NA|NA	S	Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state
C1_00655	155864.EDL933_3648	5e-177	627.1	Escherichia	perM	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944		ko:K03548,ko:K11744					ko00000,ko02000	2.A.86.1			Bacteria	1MW0B@1224,1RPVP@1236,3XMGI@561,COG0628@1,COG0628@2	NA|NA|NA	S	transporter activity
C1_00656	481805.EcolC_1184	2.9e-151	541.2	Escherichia	focA	GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0008028,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015238,GO:0015318,GO:0015499,GO:0015711,GO:0015718,GO:0015724,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0042891,GO:0042895,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098656,GO:1903825,GO:1905039		ko:K02598,ko:K03459,ko:K06212,ko:K21990,ko:K21993					ko00000,ko02000	1.A.16.1.1,1.A.16.1.2,1.A.16.1.3,1.A.16.2,1.A.16.3,1.A.16.4		iB21_1397.B21_02346,iECBD_1354.ECBD_1196,iECB_1328.ECB_02384,iECD_1391.ECD_02384,iECIAI39_1322.ECIAI39_2632,iEcSMS35_1347.EcSMS35_2639,iSF_1195.SF0899,iS_1188.S0963	Bacteria	1MU0W@1224,1RPXB@1236,3XRIU@561,COG2116@1,COG2116@2	NA|NA|NA	P	formate transporter
C1_00657	469008.B21_02345	0.0	1316.2	Escherichia	fhlA	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141		ko:K02584,ko:K12146,ko:K12266,ko:K15836	ko02020,ko05132,map02020,map05132				ko00000,ko00001,ko03000				Bacteria	1QTT3@1224,1T1G7@1236,3XN8S@561,COG3604@1,COG3604@2	NA|NA|NA	KT	Formate hydrogen-lyase transcriptional activator
C1_00658	316407.1805549	1.9e-71	275.0	Escherichia	hyfJ			ko:K12145,ko:K15834					ko00000,ko01000			iECSP_1301.ECSP_3429	Bacteria	1RHQ7@1224,1S6TA@1236,2DBX5@1,2ZBMB@2,3XP4F@561	NA|NA|NA	E	formate hydrogenlyase maturation
C1_00659	198214.SF2533	6.8e-144	516.5	Gammaproteobacteria	hyfI	GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114		ko:K12144					ko00000,ko01000			iECSP_1301.ECSP_3428,iECs_1301.ECs3351	Bacteria	1QUBE@1224,1RNUG@1236,COG3260@1,COG3260@2	NA|NA|NA	C	NADH ubiquinone oxidoreductase, 20
C1_00660	469008.B21_02342	7.6e-97	359.8	Escherichia	hyfH			ko:K12143,ko:K15831					ko00000			iAPECO1_1312.APECO1_3805,iECABU_c1320.ECABU_c29910,iECED1_1282.ECED1_3171,iECOK1_1307.ECOK1_3094,iUMN146_1321.UM146_02980,iUTI89_1310.UTI89_C3083,ic_1306.c3280	Bacteria	1R9YT@1224,1RQB1@1236,3XMEE@561,COG1143@1,COG1143@2	NA|NA|NA	C	electron transfer protein for hydrogenase
C1_00661	316407.85675422	0.0	1122.8	Escherichia	hyfG	GO:0003674,GO:0005488,GO:0016151,GO:0043167,GO:0043169,GO:0046872,GO:0046914		ko:K12142,ko:K15830					ko00000,ko01000			iECED1_1282.ECED1_3172,iEcE24377_1341.EcE24377A_2769	Bacteria	1QUBF@1224,1RSJ4@1236,3XNB6@561,COG3261@1,COG3261@2,COG3262@1,COG3262@2	NA|NA|NA	C	nickel cation binding
C1_00662	198214.SF2529	2.3e-279	967.6	Gammaproteobacteria	hyfF	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0033554,GO:0044425,GO:0044464,GO:0050896,GO:0051716,GO:0071944		ko:K12141					ko00000,ko01000			iECIAI39_1322.ECIAI39_2625,iZ_1308.Z3746	Bacteria	1MVBA@1224,1RPB3@1236,COG0651@1,COG0651@2	NA|NA|NA	CP	PFAM NADH Ubiquinone plastoquinone
C1_00663	155864.EDL933_3640	2.1e-70	271.6	Escherichia	hyfE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K12140					ko00000,ko01000				Bacteria	1NAT8@1224,1RRYF@1236,3XQCF@561,COG4237@1,COG4237@2	NA|NA|NA	C	Hydrogenase-4 component E
C1_00664	155864.EDL933_3640	4.3e-19	99.8	Escherichia	hyfE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K12140					ko00000,ko01000				Bacteria	1NAT8@1224,1RRYF@1236,3XQCF@561,COG4237@1,COG4237@2	NA|NA|NA	C	Hydrogenase-4 component E
C1_00665	155864.EDL933_3639	1.8e-57	228.4	Escherichia	hyfD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K12139					ko00000,ko01000			iEcSMS35_1347.EcSMS35_2631	Bacteria	1MW2M@1224,1RY6H@1236,3XQNF@561,COG1009@1,COG1009@2	NA|NA|NA	CP	hydrogenase 4
C1_00666	198214.SF2527	1e-115	422.9	Gammaproteobacteria	hyfD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K12139					ko00000,ko01000			iEcSMS35_1347.EcSMS35_2631	Bacteria	1MW2M@1224,1RY6H@1236,COG1009@1,COG1009@2	NA|NA|NA	CP	hydrogenase 4
C1_00667	198214.SF2527	7.7e-09	65.1	Gammaproteobacteria	hyfD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K12139					ko00000,ko01000			iEcSMS35_1347.EcSMS35_2631	Bacteria	1MW2M@1224,1RY6H@1236,COG1009@1,COG1009@2	NA|NA|NA	CP	hydrogenase 4
C1_00668	155864.EDL933_3638	8.2e-163	579.7	Escherichia	hyfC	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0033554,GO:0044464,GO:0050896,GO:0051716,GO:0071944		ko:K12138,ko:K12139,ko:K15829					ko00000,ko01000			iSFV_1184.SFV_2781,iUMNK88_1353.UMNK88_3079	Bacteria	1MXV5@1224,1RPCY@1236,3XNSF@561,COG0650@1,COG0650@2	NA|NA|NA	C	oxidoreductase activity
C1_00669	155864.EDL933_3637	1.4e-245	855.1	Escherichia	hyfB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K12137,ko:K15828					ko00000,ko01000			iECO111_1330.ECO111_3443,iECO26_1355.ECO26_3788,iEKO11_1354.EKO11_1252	Bacteria	1MXRW@1224,1RM9Q@1236,3XMXV@561,COG0651@1,COG0651@2	NA|NA|NA	CP	Formate hydrogenlyase, subunit
C1_00670	481805.EcolC_1194	3.8e-90	337.8	Escherichia	hyfB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K12137,ko:K15828					ko00000,ko01000			iECO111_1330.ECO111_3443,iECO26_1355.ECO26_3788,iEKO11_1354.EKO11_1252	Bacteria	1MXRW@1224,1RM9Q@1236,3XMXV@561,COG0651@1,COG0651@2	NA|NA|NA	CP	Formate hydrogenlyase, subunit
C1_00671	198214.SF2524	2.4e-115	421.4	Gammaproteobacteria	hyfA			ko:K05796,ko:K12136,ko:K15827					ko00000,ko01000			iEcolC_1368.EcolC_1195,iSSON_1240.SSON_2871,iUMNK88_1353.UMNK88_3076	Bacteria	1MUHW@1224,1RQWU@1236,COG1142@1,COG1142@2	NA|NA|NA	C	Formate hydrogenlyase
C1_00672	1440052.EAKF1_ch3527c	2.1e-87	328.2	Escherichia	bcp	GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016020,GO:0016209,GO:0016491,GO:0016667,GO:0016671,GO:0016684,GO:0032843,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0070887,GO:0071944,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.11.1.15	ko:K03564					ko00000,ko01000			iPC815.YPO3064	Bacteria	1RD4R@1224,1RQ7F@1236,3XNFY@561,COG1225@1,COG1225@2	NA|NA|NA	O	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events
C1_00673	155864.EDL933_3634	3.1e-101	374.4	Escherichia	gcvR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576		ko:K03567	ko02026,map02026				ko00000,ko00001,ko03000				Bacteria	1R7W7@1224,1RSDP@1236,3XN0Y@561,COG2716@1,COG2716@2	NA|NA|NA	K	Negative transcriptional regulator of the glycine cleavage system operon (GCV). Does not autoregulate its own expression. It is not yet known how GcvR acts as a repressor. It does not seem to bind DNA. It could interact with GcvA and suppress its activatory activity
C1_00674	155864.EDL933_3633	3.4e-163	580.9	Escherichia	dapA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008840,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0019877,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.72,4.3.3.7	ko:K01714,ko:K03517	ko00261,ko00300,ko00760,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map00760,map01100,map01110,map01120,map01130,map01230	M00016,M00115,M00525,M00526,M00527	R04292,R10147	RC01119,RC03062,RC03063	ko00000,ko00001,ko00002,ko01000			iECP_1309.ECP_2492,iJN746.PP_1237,iYL1228.KPN_02812	Bacteria	1MUCM@1224,1RNH9@1236,3XNCX@561,COG0329@1,COG0329@2	NA|NA|NA	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1_00675	198214.SF2520	1.1e-189	669.1	Gammaproteobacteria	bamC	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008150,GO:0009279,GO:0009986,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0042802,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045229,GO:0061024,GO:0071709,GO:0071840,GO:0071944,GO:0098552,GO:0098796,GO:1990063		ko:K07287					ko00000,ko02000	1.B.33.1			Bacteria	1MUUK@1224,1RN2X@1236,COG3317@1,COG3317@2	NA|NA|NA	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1_00677	1440052.EAKF1_ch3531	4.3e-132	477.2	Escherichia	purC	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016874,GO:0016879,GO:0016881,GO:0044424,GO:0044444,GO:0044464	4.1.1.21,4.3.2.2,6.3.2.6	ko:K01587,ko:K01756,ko:K01923	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04209,R04559,R04591	RC00064,RC00162,RC00379,RC00444,RC00445,RC00590	ko00000,ko00001,ko00002,ko01000			iAF1260.b2476,iB21_1397.B21_02330,iBWG_1329.BWG_2240,iE2348C_1286.E2348C_2713,iEC042_1314.EC042_2677,iEC55989_1330.EC55989_2759,iECABU_c1320.ECABU_c27880,iECBD_1354.ECBD_1213,iECB_1328.ECB_02368,iECDH10B_1368.ECDH10B_2642,iECDH1ME8569_1439.ECDH1ME8569_2402,iECDH1ME8569_1439.EcDH1_1193,iECD_1391.ECD_02368,iECED1_1282.ECED1_2911,iECH74115_1262.ECH74115_3698,iECIAI1_1343.ECIAI1_2527,iECNA114_1301.ECNA114_2561,iECO103_1326.ECO103_2988,iECO111_1330.ECO111_3199,iECO26_1355.ECO26_3522,iECOK1_1307.ECOK1_2784,iECP_1309.ECP_2490,iECS88_1305.ECS88_2658,iECSE_1348.ECSE_2760,iECSF_1327.ECSF_2329,iECSP_1301.ECSP_3415,iECUMN_1333.ECUMN_2789,iECW_1372.ECW_m2698,iECs_1301.ECs3338,iEKO11_1354.EKO11_1259,iETEC_1333.ETEC_2581,iEcDH1_1363.EcDH1_1193,iEcE24377_1341.EcE24377A_2757,iEcHS_1320.EcHS_A2607,iEcSMS35_1347.EcSMS35_2623,iEcolC_1368.EcolC_1200,iG2583_1286.G2583_2999,iJN746.PP_1240,iJO1366.b2476,iJR904.b2476,iLF82_1304.LF82_1775,iNRG857_1313.NRG857_12360,iSFV_1184.SFV_2521,iSF_1195.SF2519,iSFxv_1172.SFxv_2773,iS_1188.S2669,iSbBS512_1146.SbBS512_E2848,iUMNK88_1353.UMNK88_3071,iWFL_1372.ECW_m2698,iY75_1357.Y75_RS12925,iYL1228.KPN_02810,iZ_1308.Z3735	Bacteria	1MUR9@1224,1RNNY@1236,3XMYR@561,COG0152@1,COG0152@2	NA|NA|NA	F	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C1_00678	1080067.BAZH01000041_gene2608	6.3e-29	132.9	Citrobacter	mvpT			ko:K18829					ko00000,ko02048				Bacteria	1N7E4@1224,1SC95@1236,3WZK5@544,COG4456@1,COG4456@2	NA|NA|NA	S	Antidote-toxin recognition MazE, bacterial antitoxin
C1_00679	1080067.BAZH01000041_gene2607	2.1e-64	251.5	Citrobacter	vapC			ko:K18828					ko00000,ko01000,ko02048,ko03016				Bacteria	1MZB6@1224,1S4JD@1236,3WZRE@544,COG1487@1,COG1487@2	NA|NA|NA	S	PIN domain
C1_00680	155864.EDL933_3630	5.2e-164	583.6	Escherichia	ypfJ	GO:0005575,GO:0005576		ko:K07054					ko00000				Bacteria	1MU4U@1224,1RMF8@1236,3XMEM@561,COG2321@1,COG2321@2	NA|NA|NA	S	Putative neutral zinc metallopeptidase
C1_00681	481805.EcolC_1202	0.0	1321.6	Escherichia	tmcA	GO:0000049,GO:0000154,GO:0002097,GO:0002101,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008080,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0022613,GO:0030490,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0051391,GO:0051392,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1904812,GO:1990882,GO:1990883,GO:1990884	2.3.1.193,2.3.1.57	ko:K00657,ko:K06957	ko00330,ko01100,ko04216,map00330,map01100,map04216	M00135	R01154	RC00004,RC00096	ko00000,ko00001,ko00002,ko01000,ko03016				Bacteria	1NBA4@1224,1RPAM@1236,3XNM7@561,COG1444@1,COG1444@2	NA|NA|NA	J	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP)
C1_00682	155864.EDL933_3628	1.5e-129	468.8	Escherichia	ypfH	GO:0003674,GO:0003824,GO:0016787,GO:0016788,GO:0052689		ko:K06999					ko00000				Bacteria	1RA02@1224,1RN9I@1236,3XNQ7@561,COG0400@1,COG0400@2	NA|NA|NA	S	carboxylic ester hydrolase activity
C1_00683	155864.EDL933_3627	5.9e-31	139.4	Escherichia	ypfN												Bacteria	1N76H@1224,1SCQS@1236,2C6G7@1,32YJI@2,3XPZP@561	NA|NA|NA	S	Uncharacterised protein family (UPF0370)
C1_00684	198214.SF2514	2.4e-217	761.1	Gammaproteobacteria	dapE	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009014,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0032153,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0046872,GO:0046914,GO:0050897,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000			iECP_1309.ECP_2485,iIT341.HP0212	Bacteria	1MW6G@1224,1RMNQ@1236,COG0624@1,COG0624@2	NA|NA|NA	E	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1_00685	198214.SF2513	2.8e-63	247.7	Gammaproteobacteria	yffB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	1.20.4.1	ko:K00537,ko:K16509					ko00000,ko01000				Bacteria	1MZ6S@1224,1S8TR@1236,COG1393@1,COG1393@2	NA|NA|NA	P	Belongs to the ArsC family
C1_00686	316407.1799893	0.0	1974.1	Escherichia	acrD	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006855,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015238,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015307,GO:0015318,GO:0015672,GO:0015893,GO:0016020,GO:0022804,GO:0022857,GO:0022890,GO:0034220,GO:0042221,GO:0042493,GO:0044464,GO:0046618,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600		ko:K03296,ko:K18138,ko:K18324	ko01501,ko01503,ko02020,map01501,map01503,map02020	M00646,M00647,M00699,M00718			ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2,2.A.6.2.7		iE2348C_1286.E2348C_2706	Bacteria	1MU48@1224,1RMBN@1236,3XMEX@561,COG0841@1,COG0841@2	NA|NA|NA	U	efflux pump
C1_00687	316407.1799892	0.0	1087.8	Escherichia	narQ	GO:0000155,GO:0000160,GO:0000302,GO:0001101,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0006979,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009636,GO:0009927,GO:0009987,GO:0010033,GO:0010035,GO:0010167,GO:0016020,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0033554,GO:0035556,GO:0036211,GO:0042221,GO:0042493,GO:0042542,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046677,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0070887,GO:0071229,GO:0071241,GO:0071249,GO:0071250,GO:0071310,GO:0071704,GO:0071944,GO:0080033,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170	2.7.13.3	ko:K07673,ko:K07674,ko:K07678	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	M00471,M00472,M00475			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	1MWZT@1224,1RNPP@1236,3XP39@561,COG3850@1,COG3850@2	NA|NA|NA	T	Acts as a sensor for nitrate nitrite and transduces signal of nitrate nitrite availability to the NarL NarP proteins. NarQ probably activates NarL and NarP by phosphorylation. NarQ probably negatively regulates the NarL protein by dephosphorylation
C1_00688	316407.85675416	0.0	1348.6	Escherichia	gltD	GO:0003674,GO:0003824,GO:0004355,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009055,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0022900,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045181,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14	ko:K00266,ko:K05796,ko:K12136,ko:K15827	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230		R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000			iEC042_1314.EC042_3503,iSSON_1240.SSON_2871	Bacteria	1MU2H@1224,1RMY7@1236,3XNKH@561,COG0493@1,COG0493@2,COG1142@1,COG1142@2	NA|NA|NA	C	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
C1_00689	316407.1799890	9.8e-103	379.4	Escherichia	nudK	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019144,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0047631,GO:0050896,GO:0052751	3.6.1.13	ko:K01515,ko:K12945	ko00230,map00230		R01054	RC00002	ko00000,ko00001,ko01000			iECP_1309.ECP_3126,iLF82_1304.LF82_1537,iNRG857_1313.NRG857_12310,iUTI89_1310.UTI89_C2793,ic_1306.c2994	Bacteria	1MWBQ@1224,1RPUY@1236,3XMBW@561,COG0494@1,COG0494@2	NA|NA|NA	L	GDP-mannose pyrophosphatase NudK
C1_00690	316407.85675415	7.1e-200	703.0	Escherichia	ypfG												Bacteria	1MXZW@1224,1RQEU@1236,3XMJ9@561,COG5342@1,COG5342@2	NA|NA|NA	S	Protein of unknown function (DUF1176)
C1_00691	316407.1799889	0.0	1359.4	Escherichia	tkt	GO:0000302,GO:0003674,GO:0003824,GO:0004802,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006098,GO:0006139,GO:0006355,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009635,GO:0009636,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010033,GO:0010035,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016740,GO:0016744,GO:0019219,GO:0019222,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0019842,GO:0030145,GO:0030976,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0034641,GO:0035690,GO:0036094,GO:0036245,GO:0042221,GO:0042493,GO:0042542,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0046496,GO:0046677,GO:0046872,GO:0046914,GO:0048037,GO:0048518,GO:0048522,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051156,GO:0051171,GO:0051173,GO:0051186,GO:0051252,GO:0051254,GO:0051716,GO:0055086,GO:0060255,GO:0065007,GO:0070301,GO:0070887,GO:0071236,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0072524,GO:0072747,GO:0072756,GO:0080090,GO:0097159,GO:0097237,GO:1901135,GO:1901322,GO:1901360,GO:1901363,GO:1901562,GO:1901564,GO:1901654,GO:1901655,GO:1901681,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000			iECABU_c1320.ECABU_c27750,iLF82_1304.LF82_2271,iNRG857_1313.NRG857_12300,iSDY_1059.SDY_3141,iYL1228.KPN_02799,ic_1306.c2990	Bacteria	1MUEY@1224,1RMWP@1236,3XNP4@561,COG0021@1,COG0021@2	NA|NA|NA	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C1_00692	155864.EDL933_3618	4.5e-177	627.1	Escherichia	tal	GO:0003674,GO:0003824,GO:0004801,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016744,GO:0044424,GO:0044444,GO:0044464	2.2.1.2	ko:K00616,ko:K08313,ko:K08314	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000			iEC042_1314.EC042_0914,iECH74115_1262.ECH74115_5407,iECSP_1301.ECSP_5016,iECs_1301.ECs4875,iG2583_1286.G2583_4758,iYL1228.KPN_02798,iZ_1308.Z5501	Bacteria	1MWQ8@1224,1RMS0@1236,3XMID@561,COG0176@1,COG0176@2	NA|NA|NA	F	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C1_00693	155864.EDL933_3617	0.0	1474.1	Escherichia	maeB	GO:0003674,GO:0003824,GO:0004470,GO:0004473,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0055114	1.1.1.38,1.1.1.40,2.3.1.8	ko:K00027,ko:K00029,ko:K00625,ko:K04020,ko:K13788	ko00430,ko00620,ko00640,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,ko02020,map00430,map00620,map00640,map00680,map00710,map00720,map01100,map01120,map01200,map02020	M00169,M00172,M00357,M00579	R00214,R00216,R00230,R00921	RC00004,RC00105,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_1637,iE2348C_1286.E2348C_2692,iG2583_1286.G2583_2834	Bacteria	1MU0A@1224,1RN5F@1236,3XNEY@561,COG0280@1,COG0280@2,COG0281@1,COG0281@2	NA|NA|NA	C	malate dehydrogenase (decarboxylating) (NADP+) activity
C1_00694	155864.EDL933_3616	2e-55	221.5	Escherichia	eutS	GO:0003674,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0031469,GO:0031471,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464		ko:K04031					ko00000				Bacteria	1RFDA@1224,1S595@1236,3XPRX@561,COG4810@1,COG4810@2	NA|NA|NA	E	May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place
C1_00695	155864.EDL933_3615	1.3e-84	318.9	Escherichia	eutP			ko:K04029					ko00000				Bacteria	1R8GN@1224,1RRWJ@1236,3XN68@561,COG4917@1,COG4917@2	NA|NA|NA	E	ethanolamine metabolic process
C1_00696	316407.85675411	1.4e-127	462.2	Escherichia	eutQ			ko:K04019,ko:K04030	ko00564,ko01100,map00564,map01100		R00749	RC00370	ko00000,ko00001				Bacteria	1R6MF@1224,1RRZH@1236,3XMB2@561,COG4766@1,COG4766@2	NA|NA|NA	E	ethanolamine metabolic process
C1_00697	199310.c2984	7e-147	526.6	Escherichia	eutT		2.5.1.17	ko:K04032	ko00860,ko01100,map00860,map01100		R01492	RC00533	ko00000,ko00001,ko01000				Bacteria	1R4BY@1224,1RMDG@1236,3XNP6@561,COG4812@1,COG4812@2	NA|NA|NA	F	Ethanolamine utilization cobalamin adenosyltransferase
C1_00698	316407.1799884	4.3e-186	657.1	Escherichia	pta	GO:0003674,GO:0003824,GO:0004470,GO:0004473,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006083,GO:0006084,GO:0006085,GO:0006139,GO:0006163,GO:0006164,GO:0006520,GO:0006566,GO:0006567,GO:0006629,GO:0006631,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008270,GO:0008959,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009068,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016053,GO:0016054,GO:0016407,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0016999,GO:0017000,GO:0017001,GO:0017144,GO:0018130,GO:0019413,GO:0019427,GO:0019438,GO:0019541,GO:0019637,GO:0019693,GO:0019752,GO:0030145,GO:0032787,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0042737,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045733,GO:0046390,GO:0046394,GO:0046395,GO:0046459,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0070689,GO:0071616,GO:0071704,GO:0072329,GO:0072330,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606	1.1.1.40,2.3.1.8	ko:K00029,ko:K00625,ko:K04020,ko:K13788	ko00430,ko00620,ko00640,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00710,map00720,map01100,map01120,map01200	M00169,M00172,M00357,M00579	R00216,R00230,R00921	RC00004,RC00105,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000			iE2348C_1286.E2348C_2692,iG2583_1286.G2583_2834	Bacteria	1QTS5@1224,1RMJS@1236,3XNTZ@561,COG0280@1,COG0280@2	NA|NA|NA	C	phosphate acetyltransferase activity
C1_00699	199310.c2982	7.1e-53	213.0	Escherichia	eutM	GO:0003674,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0031469,GO:0031471,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464		ko:K04027,ko:K04028					ko00000				Bacteria	1RH1U@1224,1S6YK@1236,3XR19@561,COG4577@1,COG4577@2	NA|NA|NA	CQ	May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place
C1_00700	199310.c2981	2.5e-46	191.0	Escherichia	eutN	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716		ko:K04028					ko00000				Bacteria	1RIK4@1224,1S6GW@1236,3XR0M@561,COG4576@1,COG4576@2	NA|NA|NA	CQ	May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place
C1_00701	469008.B21_02308	1.6e-252	878.2	Escherichia	eutE	GO:0003674,GO:0003824,GO:0004029,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114	1.2.1.87	ko:K04021,ko:K13922	ko00620,ko00640,ko01100,ko01120,map00620,map00640,map01100,map01120		R00228,R09097	RC00004,RC00184,RC01195	ko00000,ko00001,ko01000				Bacteria	1QUBI@1224,1RP7H@1236,3XMH5@561,COG1012@1,COG1012@2	NA|NA|NA	C	Ethanolamine utilization protein EutE
C1_00702	316407.1799880	3.7e-159	567.4	Escherichia	eutJ			ko:K04024					ko00000				Bacteria	1MVXX@1224,1S06N@1236,3XNST@561,COG4820@1,COG4820@2	NA|NA|NA	E	Ethanolamine utilization
C1_00703	469008.B21_02306	1.4e-212	745.3	Escherichia	eutG	GO:0003674,GO:0003824,GO:0004022,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0044424,GO:0044444,GO:0044464,GO:0055114		ko:K04022	ko00010,ko01100,ko01110,ko01120,ko01130,map00010,map01100,map01110,map01120,map01130		R00754	RC00088	ko00000,ko00001				Bacteria	1MVPH@1224,1RMVU@1236,3XPC0@561,COG1454@1,COG1454@2	NA|NA|NA	C	Ethanolamine utilization protein eutG
C1_00704	316407.85675408	5.2e-218	763.5	Gammaproteobacteria	eutH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K04023					ko00000			iYO844.BSU39450	Bacteria	1NPK6@1224,1S0MH@1236,COG3192@1,COG3192@2	NA|NA|NA	E	ethanolamine utilization protein
C1_00705	481805.EcolC_1226	8.2e-260	902.5	Escherichia	eutA	GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0030091,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050790,GO:0051339,GO:0051349,GO:0065007,GO:0065009,GO:0071704,GO:1901564		ko:K04019	ko00564,ko01100,map00564,map01100		R00749	RC00370	ko00000,ko00001				Bacteria	1PPGT@1224,1RYIP@1236,3XNX1@561,COG4819@1,COG4819@2	NA|NA|NA	E	ethanolamine utilization protein
C1_00706	155864.EDL933_3604	6.1e-260	902.9	Escherichia	eutB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009350,GO:0032991,GO:0044424,GO:0044444,GO:0044464,GO:1902494	4.3.1.7	ko:K03735,ko:K16785	ko00564,ko01100,ko02010,map00564,map01100,map02010	M00582	R00749	RC00370	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35		iAPECO1_1312.APECO1_4107,iECOK1_1307.ECOK1_2756,iECS88_1305.ECS88_2629,iUMN146_1321.UM146_04425,iUTI89_1310.UTI89_C2774	Bacteria	1MUR4@1224,1RPN8@1236,3XN42@561,COG4303@1,COG4303@2	NA|NA|NA	E	ethanolamine ammonia-lyase activity
C1_00707	199310.c2974	5.1e-159	567.0	Escherichia	eutC	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008144,GO:0009350,GO:0019842,GO:0031419,GO:0032991,GO:0036094,GO:0044424,GO:0044464,GO:0046906,GO:0048037,GO:0097159,GO:1901363,GO:1902494	4.3.1.7	ko:K03736	ko00564,ko01100,map00564,map01100		R00749	RC00370	ko00000,ko00001,ko01000			iECNA114_1301.ECNA114_2515,iECSF_1327.ECSF_2301	Bacteria	1MWQI@1224,1RQ2T@1236,3XNZD@561,COG4302@1,COG4302@2	NA|NA|NA	E	Belongs to the EutC family
C1_00708	198214.SF2492	1.2e-115	422.5	Gammaproteobacteria	eutL	GO:0003674,GO:0005198,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0008270,GO:0031469,GO:0031471,GO:0042802,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0046872,GO:0046914		ko:K04026					ko00000				Bacteria	1QGJB@1224,1RSFT@1236,COG4816@1,COG4816@2	NA|NA|NA	E	Carboxysome structural protein involved in ethanolamine utilization
C1_00709	316407.1799868	8e-85	319.7	Escherichia	eutK	GO:0003674,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0031469,GO:0031471,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0050896		ko:K04025					ko00000				Bacteria	1RCBV@1224,1S2HK@1236,3XP2V@561,COG4577@1,COG4577@2	NA|NA|NA	CQ	Ethanolamine utilization protein EutK
C1_00710	155864.EDL933_3600	1.3e-204	718.8	Escherichia	eutR	GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006089,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009438,GO:0009987,GO:0010467,GO:0016053,GO:0016070,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019172,GO:0019243,GO:0019249,GO:0019438,GO:0019752,GO:0032774,GO:0032787,GO:0034641,GO:0034645,GO:0034654,GO:0042180,GO:0042182,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046185,GO:0046394,GO:0046483,GO:0051596,GO:0061727,GO:0071704,GO:0072330,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901575,GO:1901576,GO:1901615,GO:1901617		ko:K04033					ko00000,ko03000				Bacteria	1Q3UX@1224,1RS88@1236,3XMYS@561,COG2207@1,COG2207@2	NA|NA|NA	K	Activates the transcription of the eut operon. Also positively regulates its own transcription. Probably binds ethanolamine and vitamin B12 as effectors (By similarity)
C1_00711	469008.B21_02298	6.3e-181	639.8	Escherichia	hemF	GO:0003674,GO:0003824,GO:0004109,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016634,GO:0018130,GO:0019438,GO:0030145,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0046872,GO:0046906,GO:0046914,GO:0046983,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.3.3.3	ko:K00228	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03220	RC00884	ko00000,ko00001,ko00002,ko01000			iAF1260.b2436,iBWG_1329.BWG_2198,iECDH10B_1368.ECDH10B_2601,iECDH1ME8569_1439.ECDH1ME8569_2370,iETEC_1333.ETEC_2549,iEcDH1_1363.EcDH1_1225,iEcHS_1320.EcHS_A2573,iEcolC_1368.EcolC_1243,iJO1366.b2436,iJR904.b2436,iY75_1357.Y75_RS12760	Bacteria	1MWMF@1224,1RMM8@1236,3XMMV@561,COG0408@1,COG0408@2	NA|NA|NA	H	Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX
C1_00712	155864.EDL933_3598	1.4e-156	558.9	Escherichia	amiA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0008270,GO:0008745,GO:0016787,GO:0016810,GO:0016811,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0061783	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036			iG2583_1286.G2583_4996,iSDY_1059.SDY_3034	Bacteria	1MUQK@1224,1RMQR@1236,3XMRY@561,COG0860@1,COG0860@2	NA|NA|NA	M	N-acetylmuramoyl-L-alanine amidase amiA
C1_00713	155864.EDL933_3597	8.9e-77	292.7	Escherichia	ypeA			ko:K03826					ko00000,ko01000				Bacteria	1RA6D@1224,1S2F2@1236,3XPJV@561,COG0454@1,COG0456@2	NA|NA|NA	K	transferase activity, transferring acyl groups other than amino-acyl groups
C1_00714	469008.B21_02295	1.8e-80	305.1	Escherichia	yfeZ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1RD7G@1224,1S4HS@1236,2C10D@1,32RZ4@2,3XPS1@561	NA|NA|NA	S	Protein of unknown function (DUF2919)
C1_00715	155864.EDL933_3595	7.3e-106	389.8	Escherichia	yfeY												Bacteria	1RB4E@1224,1RRU9@1236,28PEC@1,2ZC5Z@2,3XMY9@561	NA|NA|NA	S	Protein of unknown function (DUF1131)
C1_00716	362663.ECP_2452	2.3e-170	604.7	Escherichia	yfeX	GO:0003674,GO:0003824,GO:0004601,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0020037,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0046906,GO:0048037,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1990748		ko:K07223					ko00000				Bacteria	1MWDD@1224,1RMZJ@1236,3XM48@561,COG2837@1,COG2837@2	NA|NA|NA	P	peroxidase activity
C1_00717	316407.85675401	1.7e-251	874.8	Gammaproteobacteria	yfeW	GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008658,GO:0009002,GO:0016020,GO:0016787,GO:0017171,GO:0019538,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0070008,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0140096,GO:1901363,GO:1901564,GO:1901681	3.4.16.4	ko:K21469	ko00550,map00550				ko00000,ko00001,ko01000,ko01002,ko01011				Bacteria	1QVWF@1224,1T2KR@1236,COG1680@1,COG1680@2	NA|NA|NA	V	COG1680 Beta-lactamase class C and other penicillin binding proteins
C1_00718	316407.1799859	9.1e-267	925.6	Escherichia	murP	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0006950,GO:0006974,GO:0008150,GO:0008515,GO:0008643,GO:0008645,GO:0009401,GO:0009758,GO:0009987,GO:0015144,GO:0015154,GO:0015157,GO:0015749,GO:0015764,GO:0015766,GO:0015770,GO:0015771,GO:0015772,GO:0016020,GO:0016021,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0033554,GO:0034219,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090564,GO:0090586,GO:0090588,GO:0090589,GO:1901264,GO:1904659	2.7.1.192,2.7.1.193,2.7.1.199,2.7.1.201,2.7.1.208	ko:K02749,ko:K02752,ko:K02753,ko:K02755,ko:K02756,ko:K02757,ko:K02778,ko:K02779,ko:K02790,ko:K02791,ko:K02802,ko:K02803,ko:K02804,ko:K02818,ko:K02819,ko:K11191,ko:K11192	ko00010,ko00500,ko00520,ko02060,ko05111,map00010,map00500,map00520,map02060,map05111	M00265,M00266,M00267,M00268,M00270,M00271,M00272,M00303	R02738,R02780,R04111,R04394,R05132,R05199,R08559	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.1.1,4.A.1.1.10,4.A.1.1.15,4.A.1.1.16,4.A.1.1.2,4.A.1.1.3,4.A.1.1.4,4.A.1.1.5,4.A.1.1.7,4.A.1.1.8,4.A.1.2.11,4.A.1.2.13,4.A.1.2.2,4.A.1.2.3,4.A.1.2.4,4.A.1.2.5,4.A.1.2.6,4.A.1.2.7,4.A.1.2.8		iECABU_c1320.ECABU_c48060,iECIAI39_1322.ECIAI39_2574,iECIAI39_1322.ECIAI39_2901,iECNA114_1301.ECNA114_1668,iECNA114_1301.ECNA114_2504,iECP_1309.ECP_0691,iECSF_1327.ECSF_1482,iECSF_1327.ECSF_2291,iEcHS_1320.EcHS_A3936,ic_1306.c5339	Bacteria	1N3C1@1224,1RQMX@1236,3XNT5@561,COG1263@1,COG1263@2,COG1264@1,COG1264@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is
C1_00719	469008.B21_02289	2e-158	565.1	Escherichia	murQ	GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006040,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009254,GO:0016787,GO:0016801,GO:0016803,GO:0016829,GO:0016835,GO:0030203,GO:0043170,GO:0046348,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901575	4.2.1.126	ko:K07106	ko00520,ko01100,map00520,map01100		R08555	RC00397,RC00746	ko00000,ko00001,ko01000			iECH74115_1262.ECH74115_3658,iECSP_1301.ECSP_3375,iECs_1301.ECs3299,iG2583_1286.G2583_2959	Bacteria	1MVDR@1224,1RN3P@1236,3XNV3@561,COG2103@1,COG2103@2	NA|NA|NA	S	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C1_00720	316407.1799856	3.7e-146	524.2	Escherichia	murR	GO:0001130,GO:0001131,GO:0003674,GO:0003700,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K15835,ko:K19337					ko00000,ko03000				Bacteria	1ND5W@1224,1RNCI@1236,3XNB2@561,COG1737@1,COG1737@2	NA|NA|NA	K	Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator
C1_00721	316407.85675399	1.5e-141	508.8	Escherichia													Bacteria	1MURZ@1224,1RMUM@1236,3XMSX@561,COG1028@1,COG1028@2	NA|NA|NA	IQ	oxidoreductase activity
C1_00722	469008.B21_02286	5.6e-194	683.3	Escherichia	cysP	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006790,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008152,GO:0008272,GO:0009987,GO:0015698,GO:0015709,GO:0030288,GO:0030313,GO:0031975,GO:0036173,GO:0042597,GO:0043167,GO:0043168,GO:0043199,GO:0044237,GO:0044464,GO:0051179,GO:0051234,GO:0072348,GO:1901681		ko:K02048	ko00920,ko02010,map00920,map02010	M00185			ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3		iECIAI39_1322.ECIAI39_2570	Bacteria	1QTZY@1224,1T1JH@1236,3XM7N@561,COG4150@1,COG4150@2	NA|NA|NA	P	Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate thiosulfate import. This protein specifically binds thiosulfate and is involved in its transmembrane transport
C1_00723	316407.1799843	3.6e-146	524.2	Escherichia	cysT	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008272,GO:0015698,GO:0016020,GO:0044464,GO:0051179,GO:0051234,GO:0071944,GO:0072348		ko:K02018,ko:K02046	ko00920,ko02010,map00920,map02010	M00185,M00189			ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3,3.A.1.8		iAPECO1_1312.APECO1_4122,iE2348C_1286.E2348C_2609,iECNA114_1301.ECNA114_2500,iECOK1_1307.ECOK1_2740,iECP_1309.ECP_2447,iECS88_1305.ECS88_2613,iECSF_1327.ECSF_2287,iLF82_1304.LF82_0425,iNRG857_1313.NRG857_12150,iSDY_1059.SDY_2620,iUMN146_1321.UM146_04505,iUTI89_1310.UTI89_C2757,iYL1228.KPN_02772	Bacteria	1QTTU@1224,1RS0W@1236,3XM2P@561,COG0555@1,COG0555@2	NA|NA|NA	P	Sulfate transport system permease protein CysT
C1_00724	199310.c2957	1.6e-157	562.0	Escherichia	cysW	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02046,ko:K02047	ko00920,ko02010,map00920,map02010	M00185			ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3		iJN678.cysW,iPC815.YPO3013	Bacteria	1MV8X@1224,1RNZK@1236,3XN3S@561,COG4208@1,COG4208@2	NA|NA|NA	P	Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate thiosulfate import. Probably responsible for the translocation of the substrate across the membrane
C1_00725	316407.1799841	7.4e-208	729.6	Escherichia	cysA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008144,GO:0008150,GO:0008272,GO:0008509,GO:0015075,GO:0015103,GO:0015116,GO:0015318,GO:0015399,GO:0015405,GO:0015419,GO:0015698,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034220,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043225,GO:0043492,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0072348,GO:0097159,GO:0097367,GO:0098656,GO:0098660,GO:0098661,GO:0099133,GO:1901265,GO:1901363,GO:1901682,GO:1902358	3.6.3.25,3.6.3.29	ko:K02017,ko:K02045,ko:K10112	ko00920,ko02010,map00920,map02010	M00185,M00189,M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1,3.A.1.6.1,3.A.1.6.3,3.A.1.8		iE2348C_1286.E2348C_2607,iSSON_1240.SSON_2511	Bacteria	1QTTT@1224,1RN1B@1236,3XMNN@561,COG1118@1,COG1118@2	NA|NA|NA	P	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C1_00726	469008.B21_02282	1.3e-168	599.0	Escherichia	cysM	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.47	ko:K01738,ko:K12339	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03132,R03601,R04859	RC00020,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000			iECP_1309.ECP_2444	Bacteria	1MUBE@1224,1RN6J@1236,3XM4U@561,COG0031@1,COG0031@2	NA|NA|NA	E	Belongs to the cysteine synthase cystathionine beta- synthase family
C1_00727	199310.c2954	6.6e-60	236.5	Escherichia	yfeK												Bacteria	1NBRM@1224,1S5P3@1236,2CKE6@1,32ZEV@2,3XPSY@561	NA|NA|NA	S	Family of unknown function (DUF5329)
C1_00728	198214.SF2473	4.8e-154	550.4	Gammaproteobacteria	pdxK	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008478,GO:0008614,GO:0008615,GO:0008902,GO:0009058,GO:0009108,GO:0009110,GO:0009443,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019842,GO:0030170,GO:0030955,GO:0031420,GO:0034641,GO:0036094,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0046872,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	2.7.1.35	ko:K00868	ko00750,ko01100,map00750,map01100		R00174,R01909,R02493	RC00002,RC00017	ko00000,ko00001,ko01000			iSDY_1059.SDY_2615	Bacteria	1MVC9@1224,1RMIE@1236,COG2240@1,COG2240@2	NA|NA|NA	H	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C1_00729	198214.SF2472	9.7e-86	322.8	Gammaproteobacteria	crr	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006109,GO:0006793,GO:0006796,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0009401,GO:0009892,GO:0009898,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0019222,GO:0019897,GO:0019898,GO:0031234,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045912,GO:0048519,GO:0050789,GO:0051179,GO:0051234,GO:0065007,GO:0071702,GO:0071944,GO:0080090,GO:0098552,GO:0098562		ko:K02755,ko:K02756,ko:K02757,ko:K02777	ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111	M00265,M00266,M00268,M00270,M00271,M00272,M00303,M00806	R02738,R02780,R04111,R04394,R05132,R08559	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.1.1,4.A.1.2.11,4.A.1.2.2,4.A.1.2.5,4.A.1.2.6		e_coli_core.b2417,iAF1260.b2417,iAPECO1_1312.APECO1_4128,iB21_1397.B21_02278,iBWG_1329.BWG_2179,iE2348C_1286.E2348C_2603,iEC042_1314.EC042_2626,iEC55989_1330.EC55989_2707,iECABU_c1320.ECABU_c27380,iECBD_1354.ECBD_1264,iECB_1328.ECB_02317,iECDH10B_1368.ECDH10B_2582,iECDH1ME8569_1439.ECDH1ME8569_2351,iECD_1391.ECD_02317,iECED1_1282.ECED1_2861,iECH74115_1262.ECH74115_3648,iECIAI1_1343.ECIAI1_2475,iECIAI39_1322.ECIAI39_2563,iECNA114_1301.ECNA114_2494,iECO103_1326.ECO103_2936,iECO111_1330.ECO111_3147,iECO26_1355.ECO26_3470,iECOK1_1307.ECOK1_2734,iECS88_1305.ECS88_2607,iECSE_1348.ECSE_2708,iECSF_1327.ECSF_2281,iECSP_1301.ECSP_3365,iECUMN_1333.ECUMN_2739,iECW_1372.ECW_m2646,iEKO11_1354.EKO11_1311,iETEC_1333.ETEC_2530,iEcDH1_1363.EcDH1_1244,iEcE24377_1341.EcE24377A_2704,iEcHS_1320.EcHS_A2552,iEcSMS35_1347.EcSMS35_2572,iEcolC_1368.EcolC_1261,iG2583_1286.G2583_2949,iJO1366.b2417,iJR904.b2417,iLF82_1304.LF82_0357,iNRG857_1313.NRG857_12120,iSFV_1184.SFV_2469,iSF_1195.SF2472,iSFxv_1172.SFxv_2721,iSSON_1240.SSON_2506,iS_1188.S2618,iUMN146_1321.UM146_04535,iUMNK88_1353.UMNK88_3019,iUTI89_1310.UTI89_C2751,iWFL_1372.ECW_m2646,iY75_1357.Y75_RS12665,ic_1306.c2952	Bacteria	1MWIQ@1224,1RNE3@1236,COG2190@1,COG2190@2	NA|NA|NA	G	pts system
C1_00730	155864.EDL933_3580	0.0	1091.3	Escherichia	ptsI	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006810,GO:0008150,GO:0008643,GO:0008965,GO:0009401,GO:0016740,GO:0016772,GO:0016775,GO:0019197,GO:0032991,GO:0042802,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0051179,GO:0051234,GO:0071702	2.7.1.121,2.7.3.9	ko:K05881,ko:K08483,ko:K11189,ko:K11201	ko00561,ko02060,map00561,map02060	M00306	R01012	RC00015,RC00017	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1,8.A.7		iB21_1397.B21_02277,iE2348C_1286.E2348C_2602,iEC042_1314.EC042_2625,iECBD_1354.ECBD_1265,iECB_1328.ECB_02316,iECD_1391.ECD_02316,iECH74115_1262.ECH74115_3647,iECIAI1_1343.ECIAI1_2474,iECIAI39_1322.ECIAI39_2562,iECO103_1326.ECO103_2935,iECO111_1330.ECO111_3146,iECO26_1355.ECO26_3469,iECP_1309.ECP_2440,iECSE_1348.ECSE_2707,iECSP_1301.ECSP_3364,iECUMN_1333.ECUMN_2738,iECW_1372.ECW_m2645,iECs_1301.ECs1703,iECs_1301.ECs3288,iEKO11_1354.EKO11_1312,iEcE24377_1341.EcE24377A_2703,iEcHS_1320.EcHS_A2551,iEcSMS35_1347.EcSMS35_2571,iEcolC_1368.EcolC_1262,iLF82_1304.LF82_1770,iNRG857_1313.NRG857_12115,iSBO_1134.SBO_2440,iSDY_1059.SDY_2613,iSFV_1184.SFV_2468,iSF_1195.SF2471,iSFxv_1172.SFxv_2720,iSSON_1240.SSON_2505,iS_1188.S2617,iUMNK88_1353.UMNK88_3018,iWFL_1372.ECW_m2645,iZ_1308.Z1969,iZ_1308.Z3682	Bacteria	1MUT8@1224,1RN6R@1236,3XMY3@561,COG1080@1,COG1080@2	NA|NA|NA	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C1_00731	1028307.EAE_00365	1.1e-37	162.2	Enterobacter	ptsH	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005981,GO:0006109,GO:0006793,GO:0006796,GO:0006810,GO:0008047,GO:0008150,GO:0008152,GO:0008643,GO:0008965,GO:0008982,GO:0009401,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010604,GO:0010675,GO:0010676,GO:0010906,GO:0010907,GO:0015144,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0019197,GO:0019222,GO:0022804,GO:0022857,GO:0030234,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0032881,GO:0032991,GO:0034219,GO:0043085,GO:0043467,GO:0043470,GO:0043471,GO:0044093,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045819,GO:0045913,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0051179,GO:0051234,GO:0055085,GO:0060255,GO:0062012,GO:0062013,GO:0065007,GO:0065009,GO:0070873,GO:0070875,GO:0071702,GO:0080090,GO:0098772	2.7.1.121,2.7.1.202	ko:K02768,ko:K02784,ko:K05881,ko:K08485,ko:K11183,ko:K11189	ko00051,ko00561,ko01100,ko01120,ko02060,map00051,map00561,map01100,map01120,map02060	M00273	R01012,R03232	RC00015,RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1,8.A.8.1.1		e_coli_core.b2415,iAF1260.b2415,iB21_1397.B21_02276,iBWG_1329.BWG_2177,iE2348C_1286.E2348C_2601,iEC042_1314.EC042_2624,iEC55989_1330.EC55989_2705,iECABU_c1320.ECABU_c27360,iECBD_1354.ECBD_1266,iECB_1328.ECB_02315,iECDH10B_1368.ECDH10B_2580,iECDH1ME8569_1439.ECDH1ME8569_2349,iECDH1ME8569_1439.EcDH1_1246,iECD_1391.ECD_02315,iECED1_1282.ECED1_2859,iECH74115_1262.ECH74115_3646,iECIAI1_1343.ECIAI1_2473,iECIAI39_1322.ECIAI39_2561,iECNA114_1301.ECNA114_2492,iECO103_1326.ECO103_2934,iECO111_1330.ECO111_3145,iECO26_1355.ECO26_3468,iECOK1_1307.ECOK1_2732,iECP_1309.ECP_2439,iECS88_1305.ECS88_2605,iECSE_1348.ECSE_2706,iECSF_1327.ECSF_2279,iECSP_1301.ECSP_3363,iECUMN_1333.ECUMN_2737,iECW_1372.ECW_m2644,iECs_1301.ECs3287,iEKO11_1354.EKO11_1313,iETEC_1333.ETEC_2528,iEcDH1_1363.EcDH1_1246,iEcE24377_1341.EcE24377A_2702,iEcHS_1320.EcHS_A2550,iEcSMS35_1347.EcSMS35_2570,iEcolC_1368.EcolC_1263,iG2583_1286.G2583_2947,iJO1366.b2415,iJR904.b2415,iLF82_1304.LF82_1769,iNRG857_1313.NRG857_12110,iPC815.YPO2993,iSBO_1134.SBO_2439,iSDY_1059.SDY_2612,iSFV_1184.SFV_2467,iSF_1195.SF2470,iSFxv_1172.SFxv_2719,iSSON_1240.SSON_2504,iS_1188.S2616,iSbBS512_1146.SbBS512_E2765,iUMN146_1321.UM146_04545,iUMNK88_1353.UMNK88_3017,iUTI89_1310.UTI89_C2749,iWFL_1372.ECW_m2644,iY75_1357.Y75_RS12655,iZ_1308.Z3681,ic_1306.c2950	Bacteria	1N0CV@1224,1S9R2@1236,3X2IH@547,COG1925@1,COG1925@2	NA|NA|NA	G	PTS HPr component phosphorylation site
C1_00732	155864.EDL933_3577	3.5e-177	627.5	Escherichia	cysK	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009333,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000			iAF1260.b2414,iAPECO1_1312.APECO1_4131,iB21_1397.B21_02275,iBWG_1329.BWG_2176,iE2348C_1286.E2348C_2600,iEC042_1314.EC042_2623,iEC55989_1330.EC55989_2704,iECABU_c1320.ECABU_c27350,iECBD_1354.ECBD_1267,iECB_1328.ECB_02314,iECDH10B_1368.ECDH10B_2579,iECDH1ME8569_1439.ECDH1ME8569_2348,iECD_1391.ECD_02314,iECED1_1282.ECED1_2858,iECH74115_1262.ECH74115_3645,iECIAI1_1343.ECIAI1_2472,iECNA114_1301.ECNA114_2491,iECO103_1326.ECO103_2933,iECO111_1330.ECO111_3144,iECO26_1355.ECO26_3467,iECOK1_1307.ECOK1_2731,iECP_1309.ECP_2438,iECS88_1305.ECS88_2604,iECSE_1348.ECSE_2705,iECSF_1327.ECSF_2278,iECSP_1301.ECSP_3362,iECUMN_1333.ECUMN_2736,iECW_1372.ECW_m2643,iECs_1301.ECs3286,iEKO11_1354.EKO11_1314,iETEC_1333.ETEC_2527,iEcDH1_1363.EcDH1_1247,iEcHS_1320.EcHS_A2549,iEcSMS35_1347.EcSMS35_2569,iEcolC_1368.EcolC_1264,iG2583_1286.G2583_2946,iJO1366.b2414,iJR904.b2414,iLF82_1304.LF82_0418,iNRG857_1313.NRG857_12105,iSSON_1240.SSON_2503,iSbBS512_1146.SbBS512_E2766,iUMN146_1321.UM146_04550,iUMNK88_1353.UMNK88_3016,iUTI89_1310.UTI89_C2747,iWFL_1372.ECW_m2643,iY75_1357.Y75_RS12650,iZ_1308.Z3680	Bacteria	1MUBE@1224,1RN6J@1236,3XNFV@561,COG0031@1,COG0031@2	NA|NA|NA	E	stimulation does not require O-acetylserine sulfhydrylase activity. CdiA is the toxic component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion (experiments done in strains BW25113 and X90, both K12 derivatives). This protein is not required for CDI of strain EC93, whose toxin may function by forming inner cell membrane pores
C1_00733	155864.EDL933_3576	1.8e-144	518.5	Escherichia	cysZ	GO:0000096,GO:0000097,GO:0000103,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0008150,GO:0008152,GO:0008271,GO:0008272,GO:0008324,GO:0008509,GO:0008512,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009675,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015103,GO:0015116,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015296,GO:0015318,GO:0015672,GO:0015698,GO:0016020,GO:0016021,GO:0016053,GO:0019344,GO:0019752,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044425,GO:0044459,GO:0044464,GO:0046394,GO:0051179,GO:0051234,GO:0055085,GO:0071704,GO:0071944,GO:0072348,GO:0098655,GO:0098656,GO:0098660,GO:0098661,GO:0098662,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901682,GO:1902358,GO:1902600		ko:K06203					ko00000			iJR904.b2413,iYL1228.KPN_02760	Bacteria	1MVFT@1224,1RMQT@1236,3XP0T@561,COG2981@1,COG2981@2	NA|NA|NA	E	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
C1_00734	316407.1799827	3.3e-146	524.6	Escherichia	zipA	GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0022402,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032506,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047		ko:K03528					ko00000,ko03036				Bacteria	1MVHR@1224,1RMDB@1236,3XMQT@561,COG3115@1,COG3115@2	NA|NA|NA	D	Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of
C1_00735	316407.85675396	0.0	1306.2	Escherichia	ligA	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050662,GO:0050896,GO:0051103,GO:0051287,GO:0051716,GO:0070403,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901265,GO:1901360,GO:1901363	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430		R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400			iEC55989_1330.EC55989_2701,iECABU_c1320.ECABU_c27320,iECIAI1_1343.ECIAI1_2469,iECO103_1326.ECO103_2930,iECO111_1330.ECO111_3141,iECO26_1355.ECO26_3464,iECSE_1348.ECSE_2702,iECW_1372.ECW_m2640,iEKO11_1354.EKO11_1317,iEcE24377_1341.EcE24377A_2698,iEcSMS35_1347.EcSMS35_2566,iWFL_1372.ECW_m2640,iYL1228.KPN_02758,ic_1306.c2945	Bacteria	1MV3R@1224,1RPAV@1236,3XMQY@561,COG0272@1,COG0272@2	NA|NA|NA	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C1_00736	155864.EDL933_3573	1.8e-33	147.9	Escherichia	ypeB		2.7.7.7	ko:K02342,ko:K09954,ko:K10857	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Bacteria	1N7GT@1224,1SCBX@1236,3XQ26@561,COG3530@1,COG3530@2	NA|NA|NA	S	Putative quorum-sensing-regulated virulence factor
C1_00737	155864.EDL933_3572	2.4e-181	641.3	Escherichia	yfeH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K14347					ko00000,ko02000,ko04147	2.A.93.1			Bacteria	1MUMM@1224,1RN2S@1236,3XM62@561,COG0385@1,COG0385@2	NA|NA|NA	S	symporter activity
C1_00738	198214.SF2464	2.6e-169	601.3	Gammaproteobacteria	yfeR	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1990837											Bacteria	1MUWX@1224,1RNZB@1236,COG0583@1,COG0583@2	NA|NA|NA	K	transcriptional regulator
C1_00739	469008.B21_02268	2.2e-09	68.6	Escherichia	flxA												Bacteria	1N9XP@1224,1SCAQ@1236,2DNW6@1,32ZGK@2,3XQ2I@561	NA|NA|NA	S	FlxA-like protein
C1_00744	316407.1799814	4.6e-279	966.5	Escherichia	gltX	GO:0003674,GO:0003824,GO:0004812,GO:0004818,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006424,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.17,6.1.1.24	ko:K01885,ko:K09698	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R03651,R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016			iEC042_1314.EC042_2616,iIT341.HP0476	Bacteria	1MUCR@1224,1RN3R@1236,3XMCH@561,COG0008@1,COG0008@2	NA|NA|NA	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1_00745	316407.1799813	4.4e-64	250.4	Escherichia	yfeD												Bacteria	1MYR7@1224,1S85P@1236,3XPIZ@561,COG3415@1,COG3415@2	NA|NA|NA	L	sequence-specific DNA binding
C1_00746	199310.c2934	2.6e-61	241.1	Escherichia	yfeC												Bacteria	1RGU5@1224,1S6VV@1236,3XPQD@561,COG3415@1,COG3415@2	NA|NA|NA	L	Putative transcription regulator (DUF1323)
C1_00749	316407.85675392	0.0	1436.0	Escherichia	yfeA	GO:0000302,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008081,GO:0008150,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0016020,GO:0016021,GO:0016787,GO:0016788,GO:0031224,GO:0033554,GO:0034059,GO:0034599,GO:0034614,GO:0035690,GO:0036293,GO:0036294,GO:0042221,GO:0042493,GO:0042542,GO:0042578,GO:0043900,GO:0044425,GO:0044464,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070301,GO:0070482,GO:0070887,GO:0071111,GO:0071236,GO:0071453,GO:0071454,GO:0071944,GO:0097237,GO:1900190,GO:1901700,GO:1901701											Bacteria	1RGCV@1224,1T1U0@1236,3XNQ0@561,COG2199@1,COG2199@2,COG2200@1,COG2200@2	NA|NA|NA	T	cyclic-guanylate-specific phosphodiesterase activity
C1_00750	199310.c2932	2e-206	724.9	Escherichia	nupC	GO:0003674,GO:0005215,GO:0005337,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015212,GO:0015213,GO:0015214,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015506,GO:0015672,GO:0015858,GO:0015861,GO:0015862,GO:0015864,GO:0015931,GO:0015932,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072531,GO:0098655,GO:0098660,GO:0098662,GO:1901264,GO:1901505,GO:1901642,GO:1902600		ko:K03317,ko:K11535					ko00000,ko02000	2.A.41,2.A.41.1		iECOK1_1307.ECOK1_2708	Bacteria	1MXXX@1224,1RMBX@1236,3XM5K@561,COG1972@1,COG1972@2	NA|NA|NA	U	Transports nucleosides with a high affinity except guanosine and deoxyguanosine. Driven by a proton motive force
C1_00751	199310.c2931	7.3e-220	769.6	Escherichia	mntH	GO:0000041,GO:0003674,GO:0005215,GO:0005384,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0006826,GO:0006828,GO:0006829,GO:0008150,GO:0008324,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0015075,GO:0015077,GO:0015078,GO:0015086,GO:0015291,GO:0015292,GO:0015293,GO:0015318,GO:0015672,GO:0015684,GO:0015691,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0034220,GO:0034755,GO:0042221,GO:0044425,GO:0044464,GO:0046873,GO:0046915,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0070574,GO:0070838,GO:0070887,GO:0071241,GO:0071248,GO:0071281,GO:0071421,GO:0071577,GO:0071578,GO:0071944,GO:0072511,GO:0098655,GO:0098657,GO:0098659,GO:0098660,GO:0098662,GO:0098739,GO:0099587,GO:1902600		ko:K03322					ko00000,ko02000	2.A.55.2.6,2.A.55.3		iSF_1195.SF2457,iYO844.BSU04360	Bacteria	1MW6X@1224,1RNA2@1236,3XMY0@561,COG1914@1,COG1914@2	NA|NA|NA	P	H( )-stimulated, divalent metal cation uptake system
C1_00752	155864.EDL933_3559	7.6e-44	183.0	Escherichia	ypeC												Bacteria	1RHG1@1224,1S60N@1236,2B58A@1,31Y28@2,3XPSE@561	NA|NA|NA	S	Protein of unknown function (DUF2502)
C1_00753	155864.EDL933_3558	9e-226	789.3	Escherichia	yfeO	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03281					ko00000	2.A.49			Bacteria	1MUBJ@1224,1RR1R@1236,3XM3B@561,COG0038@1,COG0038@2	NA|NA|NA	P	ion-transport protein YfeO
C1_00754	155864.EDL933_3557	9.5e-183	646.0	Escherichia	glk	GO:0003674,GO:0003824,GO:0004340,GO:0004396,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019200,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046835,GO:0046939,GO:0051156,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000			iNRG857_1313.NRG857_12000	Bacteria	1MVFI@1224,1RNUY@1236,3XP7Q@561,COG0837@1,COG0837@2	NA|NA|NA	F	Not highly important in E.coli as glucose is transported into the cell by the PTS system already as glucose 6-phosphate
C1_00755	155864.EDL933_3556	1.2e-49	202.2	Escherichia	fryB	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090582	2.7.1.202	ko:K02768,ko:K02769,ko:K02770,ko:K11202,ko:K11203	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273,M00306	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1			Bacteria	1REBG@1224,1S587@1236,3XPNP@561,COG1445@1,COG1445@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FryABC PTS system is involved in fructose transport
C1_00756	155864.EDL933_3555	1.2e-225	788.9	Escherichia	fryC	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563	2.7.1.195,2.7.1.202	ko:K02768,ko:K02769,ko:K02770,ko:K11198,ko:K11199,ko:K11200,ko:K11203	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273,M00305,M00306	R03232,R11169	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1,4.A.2.1.3			Bacteria	1R4ND@1224,1RZX0@1236,3XPEA@561,COG1299@1,COG1299@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
C1_00757	481805.EcolC_1284	3.9e-201	707.2	Escherichia	pepP	GO:0003674,GO:0003824,GO:0004177,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271,ko:K08326					ko00000,ko01000,ko01002				Bacteria	1MUZS@1224,1RYKI@1236,3XNJ0@561,COG0006@1,COG0006@2	NA|NA|NA	E	Hydrolyzes the N-terminal methionine when the next amino acid is alanine, proline or serine. The substrate preference for methionyl aminopeptidase activity is Pro Ala Ser. Also able to hydrolyze the Xaa-Pro peptide bond when the first amino acid is alanine, asparagine or methionine
C1_00758	316407.1799795	1e-190	672.5	Escherichia	ypdE	GO:0003674,GO:0003824,GO:0004177,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008238,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564		ko:K18530,ko:K20609					ko00000,ko01000,ko01002				Bacteria	1MXEU@1224,1RYRZ@1236,3XN5P@561,COG1363@1,COG1363@2	NA|NA|NA	G	Has a broad aminopeptidase activity on non-blocked peptides by progressively cleaving amino acids off the peptide substrate. Aminopeptidase activity stops at the residue before the first proline in the peptide. Cannot cleave when proline is the first N-terminal residue
C1_00759	198214.SF2449	0.0	1620.5	Gammaproteobacteria	fryA		2.7.1.121,2.7.1.194,2.7.1.195,2.7.1.200,2.7.1.202,2.7.3.9	ko:K02768,ko:K02769,ko:K02770,ko:K02773,ko:K02784,ko:K02806,ko:K02821,ko:K05881,ko:K08483,ko:K08485,ko:K11183,ko:K11184,ko:K11189,ko:K11198,ko:K11199,ko:K11200,ko:K11201	ko00051,ko00052,ko00053,ko00561,ko01100,ko01120,ko02060,map00051,map00052,map00053,map00561,map01100,map01120,map02060	M00273,M00279,M00283,M00305,M00306,M00550	R01012,R03232,R05570,R07671,R11169	RC00015,RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1,4.A.2.1.3,4.A.5.1,4.A.7.1,8.A.7,8.A.8.1.1		e_coli_core.b2415,iAF1260.b2415,iB21_1397.B21_02276,iB21_1397.B21_02277,iBWG_1329.BWG_2177,iE2348C_1286.E2348C_2601,iE2348C_1286.E2348C_2602,iEC042_1314.EC042_2624,iEC042_1314.EC042_2625,iEC55989_1330.EC55989_2705,iECABU_c1320.ECABU_c27360,iECBD_1354.ECBD_1265,iECBD_1354.ECBD_1266,iECB_1328.ECB_02315,iECB_1328.ECB_02316,iECDH10B_1368.ECDH10B_2580,iECDH1ME8569_1439.ECDH1ME8569_2349,iECDH1ME8569_1439.EcDH1_1246,iECD_1391.ECD_02315,iECD_1391.ECD_02316,iECED1_1282.ECED1_2859,iECH74115_1262.ECH74115_3646,iECH74115_1262.ECH74115_3647,iECIAI1_1343.ECIAI1_2473,iECIAI1_1343.ECIAI1_2474,iECIAI39_1322.ECIAI39_0923,iECIAI39_1322.ECIAI39_2561,iECIAI39_1322.ECIAI39_2562,iECNA114_1301.ECNA114_2492,iECO103_1326.ECO103_2934,iECO103_1326.ECO103_2935,iECO111_1330.ECO111_3145,iECO111_1330.ECO111_3146,iECO26_1355.ECO26_3468,iECO26_1355.ECO26_3469,iECOK1_1307.ECOK1_2732,iECP_1309.ECP_2439,iECP_1309.ECP_2440,iECS88_1305.ECS88_2605,iECSE_1348.ECSE_2706,iECSE_1348.ECSE_2707,iECSF_1327.ECSF_2279,iECSP_1301.ECSP_3363,iECSP_1301.ECSP_3364,iECUMN_1333.ECUMN_2737,iECUMN_1333.ECUMN_2738,iECW_1372.ECW_m2644,iECW_1372.ECW_m2645,iECs_1301.ECs3287,iECs_1301.ECs3288,iEKO11_1354.EKO11_1312,iEKO11_1354.EKO11_1313,iETEC_1333.ETEC_2528,iEcDH1_1363.EcDH1_1246,iEcE24377_1341.EcE24377A_2702,iEcE24377_1341.EcE24377A_2703,iEcHS_1320.EcHS_A2550,iEcHS_1320.EcHS_A2551,iEcSMS35_1347.EcSMS35_2570,iEcSMS35_1347.EcSMS35_2571,iEcolC_1368.EcolC_1262,iEcolC_1368.EcolC_1263,iG2583_1286.G2583_2947,iJO1366.b2415,iJR904.b2415,iLF82_1304.LF82_1769,iLF82_1304.LF82_1770,iNRG857_1313.NRG857_12110,iNRG857_1313.NRG857_12115,iSBO_1134.SBO_2155,iSBO_1134.SBO_2439,iSBO_1134.SBO_2440,iSDY_1059.SDY_2612,iSDY_1059.SDY_2613,iSFV_1184.SFV_2467,iSFV_1184.SFV_2468,iSF_1195.SF1201,iSF_1195.SF2470,iSF_1195.SF2471,iSFxv_1172.SFxv_2719,iSFxv_1172.SFxv_2720,iSSON_1240.SSON_2504,iSSON_1240.SSON_2505,iS_1188.S1285,iS_1188.S2616,iS_1188.S2617,iSbBS512_1146.SbBS512_E0794,iSbBS512_1146.SbBS512_E2765,iSbBS512_1146.SbBS512_E4725,iUMN146_1321.UM146_04545,iUMNK88_1353.UMNK88_3017,iUMNK88_1353.UMNK88_3018,iUTI89_1310.UTI89_C2749,iWFL_1372.ECW_m2644,iWFL_1372.ECW_m2645,iY75_1357.Y75_RS12655,iZ_1308.Z3681,iZ_1308.Z3682,ic_1306.c2950	Bacteria	1MUT8@1224,1RN6R@1236,COG1080@1,COG1080@2,COG1762@1,COG1762@2,COG1925@1,COG1925@2	NA|NA|NA	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C1_00760	469008.B21_02253	6.1e-165	586.6	Escherichia	ypdC	GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141											Bacteria	1R55C@1224,1S0MA@1236,3XNAV@561,COG2207@1,COG2207@2	NA|NA|NA	K	Transcriptional regulator
C1_00761	155864.EDL933_3550	3.9e-136	490.7	Escherichia	ypdB	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141		ko:K02477,ko:K07705	ko02020,map02020	M00492			ko00000,ko00001,ko00002,ko02022				Bacteria	1MVJI@1224,1RQ5T@1236,3XMRB@561,COG3279@1,COG3279@2	NA|NA|NA	K	Member of the two-component regulatory system YpdA YpdB, which is part of a nutrient-sensing regulatory network composed of YpdA YpdB, the high-affinity pyruvate signaling system BtsS BtsR and their respective target proteins, YhjX and YjiY. YpdB regulates expression of yhjX by binding to its promoter region. Activation of the YpdA YpdB signaling cascade also promotes BtsS BtsR-mediated yjiY expression
C1_00762	316407.85675386	0.0	1102.4	Escherichia	ypdA	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031224,GO:0031226,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0035556,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070887,GO:0071496,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.7.13.3	ko:K02478,ko:K07704	ko02020,map02020	M00492			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022			iECW_1372.ECW_m2327,iWFL_1372.ECW_m2327	Bacteria	1QUB1@1224,1T1RX@1236,3XNEW@561,COG3275@1,COG3275@2	NA|NA|NA	T	Member of the two-component regulatory system YpdA YpdB, which is part of a nutrient-sensing regulatory network composed of YpdA YpdB, the high-affinity pyruvate signaling system BtsS BtsR and their respective target proteins, YhjX and YjiY. YpdA activates YpdB by phosphorylation in response to high concentrations of extracellular pyruvate. Activation of the YpdA YpdB signaling cascade also promotes BtsS BtsR-mediated yjiY expression
C1_00763	316407.1799790	1.8e-239	834.7	Escherichia	yfdZ	GO:0003674,GO:0003824,GO:0004021,GO:0006082,GO:0006090,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009078,GO:0009079,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019272,GO:0019752,GO:0030632,GO:0032787,GO:0042851,GO:0042852,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0047635,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.83	ko:K10206,ko:K14261	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007			iEcSMS35_1347.EcSMS35_2531,iSBO_1134.SBO_2405	Bacteria	1MWS8@1224,1RQBM@1236,3XMF2@561,COG0436@1,COG0436@2	NA|NA|NA	E	Aminotransferase
C1_00764	155864.EDL933_3546	2.7e-179	634.4	Escherichia	lpxL	GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008951,GO:0009058,GO:0009247,GO:0009266,GO:0009311,GO:0009312,GO:0009409,GO:0009628,GO:0009987,GO:0016051,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0019752,GO:0036103,GO:0036104,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0046467,GO:0050896,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.3.1.241,2.3.1.242,2.3.1.243	ko:K02517,ko:K02560,ko:K12974	ko00540,ko01100,map00540,map01100	M00060	R05075,R05146,R10906	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005			iEC042_1314.EC042_2597,iECIAI39_1322.ECIAI39_1194,iSF_1195.SF1061,iS_1188.S1138	Bacteria	1MVNI@1224,1RMZ5@1236,3XMPR@561,COG1560@1,COG1560@2	NA|NA|NA	M	Catalyzes the transfer of palmitoleate from palmitoleoyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(palmitoleoyl)-lipid IV(A)
C1_00765	198214.SF2443	3.7e-35	153.7	Gammaproteobacteria	yfdY												Bacteria	1NFE4@1224,1SEI2@1236,2C7SD@1,330JG@2	NA|NA|NA	S	Protein of unknown function (DUF2545)
C1_00767	469008.B21_02246	8e-106	389.8	Gammaproteobacteria	yfdX												Bacteria	1RGE3@1224,1S5F4@1236,28JAR@1,2Z95M@2	NA|NA|NA	S	YfdX protein
C1_00768	198214.SF2441	1.5e-244	851.7	Gammaproteobacteria	frc	GO:0003674,GO:0003824,GO:0008150,GO:0008410,GO:0009268,GO:0009628,GO:0009987,GO:0010447,GO:0016740,GO:0016782,GO:0033608,GO:0050896,GO:0051716,GO:0071214,GO:0071467,GO:0071468,GO:0104004	2.8.3.16,2.8.3.19	ko:K07749,ko:K18702					ko00000,ko01000			iUMNK88_1353.UMNK88_2972	Bacteria	1MU2K@1224,1RNB5@1236,COG1804@1,COG1804@2	NA|NA|NA	C	acyl-CoA transferases carnitine dehydratase
C1_00769	481805.EcolC_1296	0.0	1109.0	Escherichia	oxc	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0008150,GO:0008152,GO:0008949,GO:0009056,GO:0009268,GO:0009628,GO:0009987,GO:0010447,GO:0016054,GO:0016829,GO:0016830,GO:0016831,GO:0017076,GO:0019752,GO:0019842,GO:0030554,GO:0030976,GO:0032553,GO:0032555,GO:0032559,GO:0033609,GO:0033611,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043531,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0046872,GO:0048037,GO:0050662,GO:0050896,GO:0051716,GO:0071214,GO:0071467,GO:0071468,GO:0071704,GO:0097159,GO:0097367,GO:0104004,GO:1901265,GO:1901363,GO:1901575,GO:1901681	4.1.1.8	ko:K01577	ko00630,ko01100,map00630,map01100		R01908	RC00620	ko00000,ko00001,ko01000			iEcSMS35_1347.EcSMS35_2523,iNJ661.Rv0118c	Bacteria	1MXDW@1224,1RR5B@1236,3XRIZ@561,COG0028@1,COG0028@2	NA|NA|NA	EH	Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the decarboxylation of oxalyl-CoA to yield carbon dioxide and formyl-CoA
C1_00770	155864.EDL933_3541	7.9e-166	589.7	Escherichia	yfdV	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K07088					ko00000			iECW_1372.ECW_m2605,iWFL_1372.ECW_m2605	Bacteria	1R71W@1224,1T9HF@1236,3XQ6G@561,COG0679@1,COG0679@2	NA|NA|NA	U	transmembrane transport
C1_00771	316407.1799782	8.5e-223	779.2	Escherichia	yfdE	GO:0003674,GO:0003824,GO:0008150,GO:0008410,GO:0009268,GO:0009628,GO:0009987,GO:0010447,GO:0016740,GO:0016782,GO:0033608,GO:0036412,GO:0050896,GO:0051716,GO:0071214,GO:0071467,GO:0071468,GO:0104004	2.8.3.16,2.8.3.19	ko:K07749,ko:K18702					ko00000,ko01000				Bacteria	1MU2K@1224,1RNB5@1236,3XQJV@561,COG1804@1,COG1804@2	NA|NA|NA	C	Involved in the catabolism of oxalate and in the adapatation to low pH. ACOCT serves to prime the oxalate-induced acid tolerance response (ATR) cycle by producing substrate for oxalyl-CoA decarboxylase (OXC) and formyl-coenzyme A transferase (FCOCT). Catalyzes the reversible conversion of acetyl-CoA and oxalate to oxalyl-CoA and acetate. It can also use formyl-CoA and oxalate to produce oxalyl-CoA and formate with significantly reduced specific activity
C1_00772	198214.SF2437	0.0	2371.7	Proteobacteria	evgS	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009268,GO:0009628,GO:0009927,GO:0009987,GO:0010447,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0071704,GO:0140096,GO:1901564	2.7.13.3	ko:K02486,ko:K07677,ko:K07679	ko02020,ko02026,ko05133,map02020,map02026,map05133	M00474,M00477			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	1NRP8@1224,COG0642@1,COG0784@1,COG0784@2,COG0834@1,COG0834@2,COG2198@1,COG2198@2,COG2205@2	NA|NA|NA	T	PhoQ Sensor
C1_00773	155864.EDL933_3537	4.4e-109	400.6	Gammaproteobacteria	evgA	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043565,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	3.1.4.52	ko:K02282,ko:K07686,ko:K07687,ko:K07688,ko:K07689,ko:K07690,ko:K13246,ko:K20264	ko02020,ko02024,ko02025,ko02026,ko05111,ko05133,map02020,map02024,map02025,map02026,map05111,map05133	M00473,M00474,M00475,M00477,M00697,M00818	R08991	RC00296	ko00000,ko00001,ko00002,ko01000,ko01504,ko02022,ko02035,ko02044				Bacteria	1R5PI@1224,1RP5B@1236,COG2197@1,COG2197@2	NA|NA|NA	K	response regulator
C1_00774	316407.85675380	2.4e-212	744.6	Escherichia	emrA	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0033554,GO:0042221,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071944,GO:0098552,GO:0098567		ko:K03543,ko:K07797	ko02020,map02020	M00701			ko00000,ko00001,ko00002,ko02000	8.A.1,8.A.1.1			Bacteria	1MU7I@1224,1RMAD@1236,3XP2J@561,COG1566@1,COG1566@2	NA|NA|NA	V	Multidrug resistance protein
C1_00775	316407.1799769	1.4e-284	984.9	Escherichia	emrY	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0033554,GO:0042221,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071944		ko:K03446,ko:K07786	ko02020,map02020	M00701			ko00000,ko00001,ko00002,ko02000	2.A.1.3,2.A.1.3.36			Bacteria	1RGPN@1224,1T1M7@1236,3XRN3@561,COG0477@1,COG0477@2	NA|NA|NA	EGP	multidrug resistance
C1_00776	469008.B21_02237	9.2e-253	879.0	Escherichia	dsdA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008721,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009636,GO:0009987,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0016840,GO:0016841,GO:0017144,GO:0019478,GO:0019752,GO:0019842,GO:0030170,GO:0033554,GO:0036088,GO:0036094,GO:0042221,GO:0042737,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046416,GO:0048037,GO:0050662,GO:0050896,GO:0051410,GO:0051716,GO:0070178,GO:0070279,GO:0071704,GO:0097159,GO:0098754,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901698	4.3.1.18	ko:K01753	ko00260,map00260		R00221	RC02600	ko00000,ko00001,ko01000			iECED1_1282.ECED1_2813,iLF82_1304.LF82_0525,iNRG857_1313.NRG857_11890	Bacteria	1MUJS@1224,1RNBW@1236,3XNRT@561,COG3048@1,COG3048@2	NA|NA|NA	E	D-serine dehydratase
C1_00777	362663.ECP_4591	1.6e-233	815.1	Escherichia	dsdX	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0006950,GO:0006974,GO:0008028,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0008643,GO:0009987,GO:0015075,GO:0015128,GO:0015144,GO:0015171,GO:0015175,GO:0015238,GO:0015318,GO:0015711,GO:0015718,GO:0015804,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0022889,GO:0031224,GO:0031226,GO:0032329,GO:0033554,GO:0034219,GO:0034220,GO:0035429,GO:0042221,GO:0042493,GO:0042873,GO:0042879,GO:0042940,GO:0042942,GO:0042943,GO:0042945,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1903825,GO:1905039		ko:K03299,ko:K06155,ko:K06157,ko:K13629					ko00000,ko02000	2.A.8,2.A.8.1.2,2.A.8.1.4,2.A.8.1.5		iSSON_1240.SSON_3547	Bacteria	1MUFG@1224,1RNGE@1236,3XQG5@561,COG2610@1,COG2610@2	NA|NA|NA	P	A D-serine-specific transporter, may function as a H( ) symporter
C1_00778	469008.B21_02235	2.1e-179	634.8	Escherichia	dsdC	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141		ko:K13636					ko00000,ko03000				Bacteria	1MWY0@1224,1RNMN@1236,3XQ94@561,COG0583@1,COG0583@2	NA|NA|NA	K	Transcriptional
C1_00779	198214.SF2998	6e-62	243.4	Gammaproteobacteria	yeeU			ko:K18838					ko00000,ko02048				Bacteria	1RI9Y@1224,1S8EC@1236,2BMAS@1,32FUR@2	NA|NA|NA	S	CbeA_antitoxin, type IV, cytoskeleton bundling-enhancing factor A
C1_00780	155864.EDL933_3073	1.2e-35	155.2	Escherichia	yeeT												Bacteria	1N89D@1224,1SFG4@1236,2CZYD@1,333DH@2,3XR4B@561	NA|NA|NA	S	Escherichia coli O157 H7 ortholog
C1_00781	502347.ESCAB7627_0703	2.5e-83	314.7	Escherichia	radC			ko:K03630					ko00000				Bacteria	1MW2D@1224,1S0RG@1236,3XQMM@561,COG2003@1,COG2003@2	NA|NA|NA	E	Belongs to the UPF0758 family
C1_00782	362663.ECP_3012	4.6e-93	347.1	Escherichia	klcA_1												Bacteria	1REBZ@1224,1S3SZ@1236,2921C@1,2ZPKK@2,3XQ53@561	NA|NA|NA	S	Escherichia coli O157 H7 ortholog z1656
C1_00783	362663.ECP_3011	1.2e-58	232.3	Escherichia													Bacteria	1MVTR@1224,1RMPH@1236,28H9R@1,2Z7MD@2,3XNIG@561	NA|NA|NA	S	Escherichia coli O157 H7 ortholog z1655
C1_00784	199310.c3668	8.4e-79	299.7	Escherichia													Bacteria	1MVTR@1224,1RMPH@1236,28H9R@1,2Z7MD@2,3XNIG@561	NA|NA|NA	S	Escherichia coli O157 H7 ortholog z1655
C1_00785	362663.ECP_3009	0.0	1374.8	Gammaproteobacteria				ko:K12687	ko02026,map02026				ko00000,ko00001,ko02000,ko02044	1.B.12.8.2			Bacteria	1QNFZ@1224,1RR10@1236,COG3468@1,COG3468@2	NA|NA|NA	MU	Adhesin of bacterial autotransporter system, probable stalk
C1_00786	637910.ROD_49751	7.8e-160	569.7	Citrobacter				ko:K06946					ko00000				Bacteria	1NG19@1224,1RPV6@1236,3WWDF@544,COG3596@1,COG3596@2	NA|NA|NA	S	50S ribosome-binding GTPase
C1_00787	637910.ROD_49761	1.8e-10	73.6	Gammaproteobacteria													Bacteria	1N1TX@1224,1SB2K@1236,2E0YC@1,32WEW@2	NA|NA|NA		
C1_00789	362663.ECP_3001	2.1e-111	408.3	Gammaproteobacteria													Bacteria	1RBZT@1224,1S22J@1236,28PZ6@1,2ZCIN@2	NA|NA|NA		
C1_00790	637910.ROD_49791	1.8e-30	137.9	Citrobacter				ko:K07733					ko00000,ko03000				Bacteria	1N6XK@1224,1SE2K@1236,3WYXI@544,COG3311@1,COG3311@2	NA|NA|NA	K	Prophage CP4-57 regulatory protein (AlpA)
C1_00791	199310.c2500	8.2e-102	376.3	Gammaproteobacteria													Bacteria	1MZGE@1224,1S91C@1236,2CZQX@1,32T6W@2	NA|NA|NA	S	Inovirus Gp2
C1_00792	637910.ROD_49841	1.7e-66	258.5	Citrobacter													Bacteria	1QNF9@1224,1TM0R@1236,2E2VY@1,31QW7@2,3WZM3@544	NA|NA|NA	S	Probable zinc-ribbon
C1_00793	198214.SF2980	8.7e-72	276.2	Gammaproteobacteria													Bacteria	1NSG2@1224,1SMJ6@1236,2DUUK@1,33SCF@2	NA|NA|NA	S	Probable zinc-ribbon
C1_00794	35703.DQ02_02605	6.6e-31	139.4	Gammaproteobacteria			3.4.21.53	ko:K01338	ko04112,map04112				ko00000,ko00001,ko01000,ko01002				Bacteria	1MWGE@1224,1RQKC@1236,COG4930@1,COG4930@2	NA|NA|NA	O	ATP-dependent Lon-type protease
C1_00795	198214.CP0269	2.5e-126	458.0	Gammaproteobacteria				ko:K07497					ko00000				Bacteria	1MVXQ@1224,1RPEW@1236,COG2801@1,COG2801@2	NA|NA|NA	L	Transposase and inactivated derivatives
C1_00796	316407.1742285	1.6e-216	758.4	Escherichia	insI1	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004803,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0030983,GO:0032135,GO:0032196,GO:0032991,GO:0032993,GO:0034641,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363		ko:K07482					ko00000				Bacteria	1PP49@1224,1RN7B@1236,3XQB0@561,COG2826@1,COG2826@2	NA|NA|NA	L	Transposase insI for insertion sequence element
C1_00797	469008.B21_03480	4.1e-59	233.8	Escherichia				ko:K07483					ko00000				Bacteria	1MZ5C@1224,1S9KN@1236,3XR3I@561,COG2963@1,COG2963@2	NA|NA|NA	L	Putative ATPase subunit of terminase (gpP-like)
C1_00798	469008.B21_03479	0.0	1960.7	Escherichia				ko:K07279,ko:K12678					ko00000,ko02000,ko02044	1.B.12,1.B.12.1.1,1.B.12.1.3			Bacteria	1R8WV@1224,1RPXJ@1236,3XQIF@561,COG3468@1,COG3468@2	NA|NA|NA	MU	Autotransporter beta-domain
C1_00799	155864.EDL933_0291	5.3e-26	122.9	Gammaproteobacteria				ko:K07483,ko:K07497					ko00000				Bacteria	1NZ8K@1224,1SQ2H@1236,COG2801@1,COG2801@2	NA|NA|NA	L	Integrase core domain
C1_00800	155864.EDL933_4925	2.7e-128	464.5	Gammaproteobacteria				ko:K07497					ko00000				Bacteria	1MVXQ@1224,1RPEW@1236,COG2801@1,COG2801@2	NA|NA|NA	L	Transposase and inactivated derivatives
C1_00801	469008.B21_03475	1.6e-46	191.8	Gammaproteobacteria				ko:K07483					ko00000				Bacteria	1N10J@1224,1S994@1236,COG2963@1,COG2963@2	NA|NA|NA	L	Transposase IS3 IS911 family protein
C1_00802	362663.ECP_3840	5.6e-26	123.2	Escherichia				ko:K07484					ko00000				Bacteria	1MUCX@1224,1SU06@1236,3XPCX@561,COG4372@1,COG4372@2	NA|NA|NA	S	Escherichia coli O157 H7
C1_00803	220341.16502622	3.8e-90	337.8	Salmonella				ko:K05799,ko:K13637					ko00000,ko03000				Bacteria	1QGMF@1224,1RUQH@1236,3ZJNH@590,COG2186@1,COG2186@2	NA|NA|NA	K	FCD domain
C1_00804	1080067.BAZH01000005_gene4513	5.3e-14	84.0	Citrobacter	yddV		2.7.7.65	ko:K13069			R08057		ko00000,ko01000				Bacteria	1MVCZ@1224,1RS2H@1236,3WV82@544,COG2199@1,COG3706@2	NA|NA|NA	T	Protoglobin
C1_00805	155864.EDL933_1063	1.4e-23	116.3	Gammaproteobacteria				ko:K07484					ko00000				Bacteria	1MZFT@1224,1T16B@1236,COG3436@1,COG3436@2	NA|NA|NA	L	IS66 Orf2 like protein
C1_00806	1441930.Z042_02140	5.7e-68	264.6	Serratia				ko:K07484					ko00000				Bacteria	1MUCX@1224,1SU06@1236,400BW@613,COG4372@1,COG4372@2	NA|NA|NA	S	zinc-finger binding domain of transposase IS66
C1_00807	1441930.Z042_02140	1.4e-47	196.1	Serratia				ko:K07484					ko00000				Bacteria	1MUCX@1224,1SU06@1236,400BW@613,COG4372@1,COG4372@2	NA|NA|NA	S	zinc-finger binding domain of transposase IS66
C1_00808	1441930.Z042_02140	3.9e-20	103.6	Serratia				ko:K07484					ko00000				Bacteria	1MUCX@1224,1SU06@1236,400BW@613,COG4372@1,COG4372@2	NA|NA|NA	S	zinc-finger binding domain of transposase IS66
C1_00809	371042.NG99_03210	1.5e-23	114.8	Erwinia				ko:K07493					ko00000				Bacteria	1MU4P@1224,1RNB3@1236,3X73I@551,COG3328@1,COG3328@2	NA|NA|NA	L	silverDB
C1_00810	371042.NG99_03210	5.2e-65	253.8	Erwinia				ko:K07493					ko00000				Bacteria	1MU4P@1224,1RNB3@1236,3X73I@551,COG3328@1,COG3328@2	NA|NA|NA	L	silverDB
C1_00811	155864.EDL933_1049	4.1e-20	103.2	Gammaproteobacteria				ko:K07483					ko00000				Bacteria	1NINX@1224,1SUIS@1236,COG2963@1,COG2963@2	NA|NA|NA	L	Transposase
C1_00812	316407.1742285	7e-217	759.6	Escherichia	insI1	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004803,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0030983,GO:0032135,GO:0032196,GO:0032991,GO:0032993,GO:0034641,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363		ko:K07482					ko00000				Bacteria	1PP49@1224,1RN7B@1236,3XQB0@561,COG2826@1,COG2826@2	NA|NA|NA	L	Transposase insI for insertion sequence element
C1_00813	469008.B21_04112	1.5e-152	545.4	Escherichia				ko:K07497					ko00000				Bacteria	1MVXQ@1224,1RY3S@1236,3XRKT@561,COG2801@1,COG2801@2	NA|NA|NA	L	Integrase core domain
C1_00815	220341.16502621	1.6e-164	585.5	Salmonella													Bacteria	1MWX0@1224,1RR1W@1236,3ZIS0@590,COG1063@1,COG1063@2	NA|NA|NA	E	Alcohol dehydrogenase GroES-like domain
C1_00816	90371.CY43_07860	9.3e-226	789.3	Salmonella													Bacteria	1P05X@1224,1RRNZ@1236,3ZKNP@590,COG2271@1,COG2271@2	NA|NA|NA	G	Major Facilitator Superfamily
C1_00817	199310.c2511	6.6e-47	193.0	Escherichia													Bacteria	1MWQX@1224,1RPJM@1236,3XPQ9@561,COG1484@1,COG1484@2	NA|NA|NA	L	Residues 1 to 244 of 251 are 41.60 pct identical to residues 1 to 250 of 298 from SwissProt.40 sp P55500 Y4IQ_RHISN
C1_00819	571.MC52_00025	0.0	1241.5	Gammaproteobacteria			1.3.3.6	ko:K00232	ko00071,ko00592,ko01040,ko01100,ko01110,ko01212,ko03320,ko04024,ko04146,map00071,map00592,map01040,map01100,map01110,map01212,map03320,map04024,map04146	M00087,M00113	R01175,R01279,R03777,R03857,R03990,R04751,R04754,R07888,R07892,R07896,R07934,R07950	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000				Bacteria	1QUB7@1224,1T1S1@1236,COG3793@1,COG3793@2	NA|NA|NA	P	TerB-C domain
C1_00820	371042.NG99_02560	1.2e-239	835.5	Gammaproteobacteria													Bacteria	1N323@1224,1RR2E@1236,COG1135@1,COG1135@2	NA|NA|NA	P	P-loop Domain of unknown function (DUF2791)
C1_00821	371042.NG99_02565	0.0	1310.8	Gammaproteobacteria	lhr			ko:K03724					ko00000,ko01000,ko03400				Bacteria	1MUSW@1224,1RSNV@1236,COG1201@1,COG1201@2	NA|NA|NA	L	helicase
C1_00822	207954.MED92_03563	3.6e-15	89.4	Oceanospirillales													Bacteria	1NF2S@1224,1SE4Z@1236,1XMWC@135619,2EA4V@1,3349S@2	NA|NA|NA		
C1_00823	1346791.M529_14175	2.5e-120	439.9	Bacteria													Bacteria	2CWVW@1,32T0E@2	NA|NA|NA		
C1_00824	198214.SF3703	3.3e-41	174.1	Gammaproteobacteria				ko:K07483					ko00000				Bacteria	1RHBZ@1224,1S69Y@1236,COG2963@1,COG2963@2	NA|NA|NA	L	Transposase
C1_00825	198214.SF3702	8.6e-47	193.0	Gammaproteobacteria				ko:K07497					ko00000				Bacteria	1MVXQ@1224,1RR4F@1236,COG2801@1,COG2801@2	NA|NA|NA	L	COG2801 Transposase and inactivated derivatives
C1_00826	362663.ECP_0283	2.3e-80	304.7	Escherichia				ko:K07497					ko00000				Bacteria	1MVXQ@1224,1RR4F@1236,3XR46@561,COG2801@1,COG2801@2	NA|NA|NA	L	Integrase core domain
C1_00828	521000.PROVRETT_05962	5.3e-175	620.5	Providencia													Bacteria	1MU23@1224,1RMJ1@1236,3Z8AA@586,COG0582@1,COG0582@2	NA|NA|NA	L	Belongs to the 'phage' integrase family
C1_00830	155864.EDL933_3517	3.5e-166	590.9	Escherichia	yfdC	GO:0003674,GO:0005215,GO:0005342,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0008028,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015238,GO:0015318,GO:0015499,GO:0015711,GO:0015718,GO:0015724,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0042802,GO:0042891,GO:0042895,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098656,GO:1903825,GO:1905039		ko:K02598,ko:K03459,ko:K06212,ko:K21990,ko:K21993					ko00000,ko02000	1.A.16.1.1,1.A.16.1.2,1.A.16.1.3,1.A.16.2,1.A.16.3,1.A.16.4		iECIAI39_1322.ECIAI39_2632,iEcSMS35_1347.EcSMS35_2639,iSF_1195.SF0899,iS_1188.S0963	Bacteria	1N8YM@1224,1RPJ0@1236,3XN9Y@561,COG2116@1,COG2116@2	NA|NA|NA	P	formate transmembrane transporter activity
C1_00831	155864.EDL933_3515	1.9e-146	525.0	Escherichia	vacJ	GO:0006810,GO:0006811,GO:0006820,GO:0006869,GO:0008150,GO:0009987,GO:0010876,GO:0015711,GO:0015748,GO:0015914,GO:0016043,GO:0033036,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071840,GO:0120009,GO:0120010		ko:K04754					ko00000				Bacteria	1MVX0@1224,1RNPS@1236,3XPDN@561,COG2853@1,COG2853@2	NA|NA|NA	M	Actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane
C1_00832	481805.EcolC_1308	1.3e-196	692.2	Gammaproteobacteria													Bacteria	1NT0J@1224,1SJK0@1236,2DU94@1,33PFH@2	NA|NA|NA		
C1_00833	481805.EcolC_1309	1.6e-260	904.8	Escherichia	fadL	GO:0003674,GO:0005215,GO:0005319,GO:0005324,GO:0005342,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0006869,GO:0008028,GO:0008150,GO:0008509,GO:0008514,GO:0009279,GO:0010876,GO:0015075,GO:0015245,GO:0015267,GO:0015288,GO:0015318,GO:0015483,GO:0015711,GO:0015718,GO:0015849,GO:0015908,GO:0015909,GO:0016020,GO:0019867,GO:0022803,GO:0022829,GO:0022834,GO:0022836,GO:0022857,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0034220,GO:0044462,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098656,GO:1903825,GO:1905039		ko:K06076					ko00000,ko02000	1.B.9		iECs_1301.ECs3227,iG2583_1286.G2583_2880,iZ_1308.Z3608	Bacteria	1MUU4@1224,1RQZJ@1236,3XNI3@561,COG2067@1,COG2067@2	NA|NA|NA	M	Involved in translocation of long-chain fatty acids across the outer membrane
C1_00834	1440052.EAKF1_ch3629	2.1e-45	188.0	Escherichia	yfcZ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Bacteria	1N0DI@1224,1S91T@1236,3XPUF@561,COG3691@1,COG3691@2	NA|NA|NA	S	Protein of unknown function (DUF406)
C1_00835	316407.85675365	9.7e-239	832.4	Escherichia	fadI	GO:0003674,GO:0003824,GO:0003857,GO:0003988,GO:0004300,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0033542,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	2.3.1.16	ko:K00632	ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212	M00087,M00113	R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000			iECO103_1326.ECO103_2806,iEcHS_1320.EcHS_A2493	Bacteria	1MU5G@1224,1RNGU@1236,3XMTM@561,COG0183@1,COG0183@2	NA|NA|NA	I	Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed
C1_00836	155864.EDL933_3509	0.0	1387.1	Escherichia	fadJ	GO:0003674,GO:0003824,GO:0003857,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0008692,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016856,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8	ko:K01782,ko:K01825	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R04756,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01078,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000			iECABU_c1320.ECABU_c26730,iETEC_1333.ETEC_2476,iEcE24377_1341.EcE24377A_2637,iLF82_1304.LF82_0614,iNRG857_1313.NRG857_19200,ic_1306.c2886	Bacteria	1MU9P@1224,1RMZ8@1236,3XMJZ@561,COG1024@1,COG1024@2,COG1250@1,COG1250@2	NA|NA|NA	I	Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities
C1_00837	316407.85675364	5.4e-86	323.6	Escherichia	sixA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0071704,GO:1901564		ko:K08296					ko00000,ko01000				Bacteria	1NAAE@1224,1SD0B@1236,3XMMS@561,COG2062@1,COG2062@2	NA|NA|NA	T	Phosphohistidine phosphatase sixA
C1_00838	198214.SF2415	4.6e-97	360.5	Gammaproteobacteria	yfcV	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0007155,GO:0008150,GO:0009279,GO:0009297,GO:0009987,GO:0015267,GO:0015288,GO:0015473,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0022610,GO:0022803,GO:0022829,GO:0022857,GO:0030030,GO:0030031,GO:0030312,GO:0030313,GO:0031975,GO:0043711,GO:0044085,GO:0044462,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071840,GO:0071944		ko:K07345	ko05133,map05133				ko00000,ko00001,ko02035,ko02044				Bacteria	1NDMB@1224,1SCDX@1236,COG3539@1,COG3539@2	NA|NA|NA	NU	Part of the yfcOPQRSUV fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes
C1_00839	481805.EcolC_1315	0.0	1761.5	Escherichia	yfcU	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0009279,GO:0009297,GO:0009987,GO:0015267,GO:0015288,GO:0015473,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0022803,GO:0022829,GO:0022857,GO:0030030,GO:0030031,GO:0030312,GO:0030313,GO:0031975,GO:0043711,GO:0044085,GO:0044462,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071840,GO:0071944											Bacteria	1P744@1224,1RN8Z@1236,3XMH0@561,COG3188@1,COG3188@2	NA|NA|NA	NU	outer membrane usher protein
C1_00840	316407.1799727	2.4e-125	454.9	Escherichia	yfcS	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006457,GO:0006950,GO:0006974,GO:0007155,GO:0008150,GO:0009987,GO:0016043,GO:0022610,GO:0030030,GO:0030288,GO:0030313,GO:0031975,GO:0033554,GO:0042597,GO:0043711,GO:0044183,GO:0044464,GO:0050896,GO:0051716,GO:0061077,GO:0071840		ko:K07346,ko:K07353,ko:K15540					ko00000,ko02035,ko02044,ko03110				Bacteria	1NSX3@1224,1SKBU@1236,3XQKN@561,COG3121@1,COG3121@2	NA|NA|NA	M	Part of the yfcOPQRSUV fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes
C1_00841	198214.SF2411	1.6e-88	332.0	Gammaproteobacteria	yfcR	GO:0007155,GO:0008150,GO:0022610											Bacteria	1MZDF@1224,1SBTB@1236,COG3539@1,COG3539@2	NA|NA|NA	NU	Fimbrial protein
C1_00842	198214.SF2410	7.1e-83	313.2	Gammaproteobacteria	yfcQ	GO:0007155,GO:0008150,GO:0022610											Bacteria	1REAV@1224,1S7WR@1236,COG3539@1,COG3539@2	NA|NA|NA	NU	Fimbrial
C1_00843	198214.SF2409	4.8e-80	303.9	Gammaproteobacteria	yfcP	GO:0005575,GO:0005623,GO:0007155,GO:0008150,GO:0009289,GO:0022610,GO:0042995,GO:0044464											Bacteria	1RIHS@1224,1SBX8@1236,COG3539@1,COG3539@2	NA|NA|NA	NU	Part of the yfcOPQRSUV fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes
C1_00844	198214.SF2408	4.8e-145	520.4	Gammaproteobacteria	yfcO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Bacteria	1RDMI@1224,1S4XD@1236,29J73@1,3064I@2	NA|NA|NA	S	Protein of unknown function (DUF2544)
C1_00845	198214.SF2406	6.8e-101	373.2	Gammaproteobacteria	yfcN												Bacteria	1MVS6@1224,1RPXD@1236,COG2840@1,COG2840@2	NA|NA|NA	S	Belongs to the UPF0115 family
C1_00846	469008.B21_02215	7.2e-180	636.3	Escherichia	prmB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006304,GO:0006305,GO:0006306,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009007,GO:0009008,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0032775,GO:0034641,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0044728,GO:0046483,GO:0071704,GO:0090304,GO:0140096,GO:0140097,GO:1901360,GO:1901564	2.1.1.297,2.1.1.298	ko:K02493,ko:K07320			R10806	RC00003,RC03279	ko00000,ko01000,ko03009,ko03012				Bacteria	1MX8Q@1224,1RPHQ@1236,3XNMW@561,COG2890@1,COG2890@2	NA|NA|NA	J	Specifically methylates the 50S ribosomal protein L3 on
C1_00847	155864.EDL933_3497	6.9e-206	723.0	Escherichia	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000			iE2348C_1286.E2348C_2469,iEC55989_1330.EC55989_2573,iECO103_1326.ECO103_2794,iECO111_1330.ECO111_3077,iECO26_1355.ECO26_3317,iECSE_1348.ECSE_2638,iECW_1372.ECW_m2518,iEKO11_1354.EKO11_1436,iIT341.HP0663,iSSON_1240.SSON_2387,iUMNK88_1353.UMNK88_2882,iWFL_1372.ECW_m2518	Bacteria	1MU98@1224,1RMQS@1236,3XNA3@561,COG0082@1,COG0082@2	NA|NA|NA	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C1_00848	481805.EcolC_1324	6.9e-158	563.1	Escherichia	mepA	GO:0000270,GO:0003674,GO:0003824,GO:0004175,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016787,GO:0019538,GO:0030203,GO:0034645,GO:0042221,GO:0042493,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0050896,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576		ko:K07261					ko00000,ko01000,ko01002,ko01011			iAPECO1_1312.APECO1_4236,iE2348C_1286.E2348C_2468,iECABU_c1320.ECABU_c26610,iECED1_1282.ECED1_2792,iECIAI39_1322.ECIAI39_2477,iECOK1_1307.ECOK1_2610,iECS88_1305.ECS88_2476,iEcSMS35_1347.EcSMS35_2485,iLF82_1304.LF82_1316,iNRG857_1313.NRG857_11790,iUMN146_1321.UM146_05170,iUTI89_1310.UTI89_C2613,ic_1306.c2874	Bacteria	1MU9I@1224,1RMJK@1236,3XMNR@561,COG3770@1,COG3770@2	NA|NA|NA	M	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
C1_00849	155864.EDL933_3495	1.3e-140	505.8	Escherichia	yfcA	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016020,GO:0044464,GO:0050896,GO:0071944		ko:K07090,ko:K11312					ko00000				Bacteria	1MXNM@1224,1RRH4@1236,3XN7S@561,COG0730@1,COG0730@2	NA|NA|NA	S	membrane transporter protein
C1_00850	481805.EcolC_1326	4.3e-108	397.1	Escherichia	yfcM	GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016705,GO:0016709,GO:0017185,GO:0018126,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0055114,GO:0071704,GO:0072580,GO:1901260,GO:1901564		ko:K09906					ko00000,ko01000,ko03012				Bacteria	1MWTG@1224,1RNHD@1236,3XNI5@561,COG3101@1,COG3101@2	NA|NA|NA	S	Is involved in the final hydroxylation step of the post- translational modification of translation elongation factor P (EF- P) on 'Lys-34'. Acts after beta-lysylation of 'Lys-34' by EpmA and EpmB. EpmC adds an oxygen atom to the C5 position of 'Lys-34' and does not modify the added beta-lysine
C1_00851	155864.EDL933_3493	4.2e-43	180.3	Escherichia	yfcL	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Bacteria	1N0DT@1224,1S9BA@1236,2CJ8F@1,32SAV@2,3XPZB@561	NA|NA|NA	S	YfcL protein
C1_00852	316407.85675355	0.0	1370.9	Escherichia	mnmC	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0004808,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016491,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0071949,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363	2.1.1.61,2.1.1.72,2.4.2.29,4.2.1.151	ko:K00773,ko:K07319,ko:K11782,ko:K15461	ko00130,ko01110,map00130,map01110		R00601,R03789,R08702,R10209,R10666	RC00003,RC00053,RC00060,RC00063,RC01483,RC03232	ko00000,ko00001,ko01000,ko02048,ko03016				Bacteria	1MZW5@1224,1RMTE@1236,3XMNY@561,COG0665@1,COG0665@2,COG4121@1,COG4121@2	NA|NA|NA	J	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C1_00853	155864.EDL933_3490	6.1e-227	793.1	Escherichia	fabB	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.41	ko:K00647	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004			iAF1260.b2323,iAPECO1_1312.APECO1_4241,iB21_1397.B21_02208,iBWG_1329.BWG_2097,iE2348C_1286.E2348C_2463,iEC042_1314.EC042_2564,iEC55989_1330.EC55989_2567,iECABU_c1320.ECABU_c26560,iECBD_1354.ECBD_1336,iECB_1328.ECB_02248,iECDH10B_1368.ECDH10B_2485,iECDH1ME8569_1439.ECDH1ME8569_2261,iECD_1391.ECD_02248,iECED1_1282.ECED1_2787,iECIAI1_1343.ECIAI1_2400,iECIAI39_1322.ECIAI39_2472,iECNA114_1301.ECNA114_2414,iECO103_1326.ECO103_2787,iECO111_1330.ECO111_3071,iECO26_1355.ECO26_3311,iECOK1_1307.ECOK1_2605,iECP_1309.ECP_2362,iECS88_1305.ECS88_2471,iECSE_1348.ECSE_2632,iECSF_1327.ECSF_2200,iECUMN_1333.ECUMN_2663,iECW_1372.ECW_m2512,iEKO11_1354.EKO11_1442,iETEC_1333.ETEC_2459,iEcDH1_1363.EcDH1_1333,iEcHS_1320.EcHS_A2474,iEcSMS35_1347.EcSMS35_2480,iEcolC_1368.EcolC_1329,iJO1366.b2323,iJR904.b2323,iLF82_1304.LF82_0605,iNRG857_1313.NRG857_11765,iSBO_1134.SBO_2360,iUMN146_1321.UM146_05195,iUTI89_1310.UTI89_C2608,iWFL_1372.ECW_m2512,iY75_1357.Y75_RS12180,ic_1306.c2869	Bacteria	1MU1X@1224,1RMDE@1236,3XMTP@561,COG0304@1,COG0304@2	NA|NA|NA	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids
C1_00854	469008.B21_02207	2.4e-212	744.6	Escherichia	yfcJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1MXYJ@1224,1RPQJ@1236,3XN13@561,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
C1_00855	362663.ECP_2360	1.6e-177	628.6	Escherichia	flk												Bacteria	1R3XT@1224,1RRUR@1236,2BXIF@1,2Z805@2,3XNYF@561	NA|NA|NA	N	Acts as a regulator of flagellar gene expression by modulating the protein level of the anti sigma factor FlgM upon sensing ring completion or hook elongation. Flk could inhibit FlgM secretion by acting as a braking system for the flagellar- associated type III secretion
C1_00856	199310.c2865	2.9e-215	754.2	Escherichia	pdxB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0033711,GO:0034641,GO:0036001,GO:0036094,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	1.1.1.290	ko:K03473	ko00750,ko01100,map00750,map01100	M00124	R04210	RC00084	ko00000,ko00001,ko00002,ko01000			iZ_1308.Z3582	Bacteria	1N5TD@1224,1RMFW@1236,3XNMJ@561,COG0111@1,COG0111@2	NA|NA|NA	H	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate
C1_00857	198214.SF2395	1.8e-184	651.7	Gammaproteobacteria	asd	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004073,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006553,GO:0006555,GO:0006566,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009081,GO:0009082,GO:0009085,GO:0009086,GO:0009088,GO:0009089,GO:0009097,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000			iECP_1309.ECP_3527	Bacteria	1MUHG@1224,1RNB6@1236,COG0136@1,COG0136@2	NA|NA|NA	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C1_00858	155864.EDL933_3484	6.4e-156	556.6	Escherichia	truA	GO:0000049,GO:0001522,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0030312,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363	5.4.99.12	ko:K06173					ko00000,ko01000,ko03016				Bacteria	1MUYI@1224,1RMK2@1236,3XNAY@561,COG0101@1,COG0101@2	NA|NA|NA	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
C1_00859	199310.c2862	1.4e-113	415.6	Escherichia	dedA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03975					ko00000				Bacteria	1MX4M@1224,1RPB1@1236,3XMPI@561,COG0586@1,COG0586@2	NA|NA|NA	S	SNARE associated Golgi protein
C1_00860	155864.EDL933_3482	1.2e-166	592.4	Escherichia	accD	GO:0001676,GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0003729,GO:0003824,GO:0003989,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006417,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0009058,GO:0009317,GO:0009329,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0017148,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032787,GO:0032991,GO:0034248,GO:0034249,GO:0042759,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:0097159,GO:1901363,GO:1901576,GO:1902494,GO:1990234,GO:2000112,GO:2000113	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000			iJN678.accD,iPC815.YPO2768,iUTI89_1310.UTI89_C2601	Bacteria	1MW8G@1224,1RNDS@1236,3XMCZ@561,COG0777@1,COG0777@2	NA|NA|NA	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C1_00861	199310.c2860	1.3e-240	838.6	Escherichia	folC	GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_2475,iJN746.PP_1997,iSDY_1059.SDY_2514	Bacteria	1MVCH@1224,1RMB0@1236,3XPHJ@561,COG0285@1,COG0285@2	NA|NA|NA	H	Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives
C1_00862	316407.85675354	6.4e-98	363.6	Escherichia	dedD	GO:0000910,GO:0003674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0007049,GO:0008150,GO:0009987,GO:0022402,GO:0030428,GO:0032153,GO:0032506,GO:0042834,GO:0044464,GO:0051301,GO:0097367		ko:K02453,ko:K03749	ko03070,ko05111,map03070,map05111	M00331			ko00000,ko00001,ko00002,ko02044	3.A.15			Bacteria	1MXHQ@1224,1RRKM@1236,3XMJM@561,COG3147@1,COG3147@2	NA|NA|NA	D	Non-essential cell division protein that could be required for efficient cell constriction
C1_00863	1440052.EAKF1_ch3660	1.1e-81	309.3	Escherichia	cvpA	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009403,GO:0009404,GO:0009987,GO:0016020,GO:0019748,GO:0044237,GO:0044249,GO:0044464,GO:0044550,GO:0071944		ko:K03558					ko00000				Bacteria	1NF4G@1224,1RQ58@1236,3XNHX@561,COG1286@1,COG1286@2	NA|NA|NA	S	colicin V production
C1_00864	198214.SF2388	4.5e-288	996.5	Gammaproteobacteria	purF	GO:0003674,GO:0003824,GO:0004044,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006520,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009117,GO:0009165,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019752,GO:0034641,GO:0034654,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002			iAF1260.b2312,iB21_1397.B21_02197,iBWG_1329.BWG_2086,iECBD_1354.ECBD_1347,iECB_1328.ECB_02237,iECDH10B_1368.ECDH10B_2474,iECDH1ME8569_1439.ECDH1ME8569_2250,iECD_1391.ECD_02237,iECIAI1_1343.ECIAI1_2389,iECO103_1326.ECO103_2776,iECO111_1330.ECO111_3060,iECO26_1355.ECO26_3300,iECW_1372.ECW_m2501,iEKO11_1354.EKO11_1453,iETEC_1333.ETEC_2448,iEcDH1_1363.EcDH1_1344,iEcE24377_1341.EcE24377A_2606,iEcolC_1368.EcolC_1340,iJO1366.b2312,iJR904.b2312,iSF_1195.SF2388,iSFxv_1172.SFxv_2633,iSSON_1240.SSON_2370,iS_1188.S2523,iSbBS512_1146.SbBS512_E2690,iUMNK88_1353.UMNK88_2863,iWFL_1372.ECW_m2501,iY75_1357.Y75_RS12125	Bacteria	1MU0V@1224,1RMYA@1236,COG0034@1,COG0034@2	NA|NA|NA	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C1_00865	155864.EDL933_3477	1.5e-98	365.5	Escherichia	ubiX	GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000			iAF1260.b2311,iAPECO1_1312.APECO1_4253,iB21_1397.B21_02196,iBWG_1329.BWG_2085,iE2348C_1286.E2348C_2451,iEC55989_1330.EC55989_2555,iECBD_1354.ECBD_1348,iECB_1328.ECB_02236,iECDH10B_1368.ECDH10B_2473,iECDH1ME8569_1439.ECDH1ME8569_2249,iECD_1391.ECD_02236,iECED1_1282.ECED1_2775,iECH74115_1262.ECH74115_3451,iECIAI39_1322.ECIAI39_2460,iECNA114_1301.ECNA114_2401,iECO103_1326.ECO103_2775,iECOK1_1307.ECOK1_2544,iECP_1309.ECP_2350,iECS88_1305.ECS88_2458,iECSE_1348.ECSE_2620,iECSF_1327.ECSF_2187,iECSP_1301.ECSP_3186,iECs_1301.ECs3195,iETEC_1333.ETEC_2447,iEcDH1_1363.EcDH1_1345,iEcE24377_1341.EcE24377A_2605,iEcHS_1320.EcHS_A2462,iEcSMS35_1347.EcSMS35_2467,iG2583_1286.G2583_2848,iJO1366.b2311,iJR904.b2311,iLF82_1304.LF82_2354,iNRG857_1313.NRG857_11705,iSDY_1059.SDY_2510,iUMN146_1321.UM146_05255,iUMNK88_1353.UMNK88_2862,iUTI89_1310.UTI89_C2595,iY75_1357.Y75_RS12120,iZ_1308.Z3573	Bacteria	1RA0P@1224,1RPN1@1236,3XMA5@561,COG0163@1,COG0163@2	NA|NA|NA	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN
C1_00866	155864.EDL933_3476	1.4e-139	502.3	Escherichia	argT	GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0006950,GO:0006995,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010035,GO:0010038,GO:0010043,GO:0015711,GO:0015807,GO:0015822,GO:0015849,GO:0015893,GO:0030288,GO:0030313,GO:0031667,GO:0031668,GO:0031669,GO:0031975,GO:0033554,GO:0042221,GO:0042493,GO:0042594,GO:0042597,GO:0043562,GO:0044464,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0070887,GO:0071241,GO:0071248,GO:0071294,GO:0071496,GO:0071702,GO:0071705,GO:1902022		ko:K10013,ko:K10014	ko02010,map02010	M00225,M00226			ko00000,ko00001,ko00002,ko02000	3.A.1.3.1		iEC042_1314.EC042_2551,iSDY_1059.SDY_2508	Bacteria	1NT2J@1224,1RRYR@1236,3XNBB@561,COG0834@1,COG0834@2	NA|NA|NA	ET	belongs to the bacterial solute-binding protein 3 family
C1_00867	155864.EDL933_3475	6.6e-142	510.0	Escherichia	hisJ	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0016597,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0043177,GO:0044464		ko:K10013,ko:K10014	ko02010,map02010	M00225,M00226			ko00000,ko00001,ko00002,ko02000	3.A.1.3.1		iEC042_1314.EC042_2551,iSDY_1059.SDY_2508	Bacteria	1NT2J@1224,1RRYR@1236,3XNFP@561,COG0834@1,COG0834@2	NA|NA|NA	ET	Part of the histidine permease ABC transporter. Binds histidine. Interacts with HisQMP and stimulates ATPase activity of HisP, which results in histidine translocation (By similarity)
C1_00868	199310.c2850	3.1e-119	434.5	Escherichia	hisQ	GO:0003333,GO:0003674,GO:0005215,GO:0005287,GO:0005290,GO:0005291,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015174,GO:0015179,GO:0015238,GO:0015318,GO:0015711,GO:0015802,GO:0015807,GO:0015849,GO:0015893,GO:0016020,GO:0022857,GO:0034220,GO:0042221,GO:0042493,GO:0043090,GO:0044464,GO:0045117,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0089709,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098739,GO:1901474,GO:1902475,GO:1903810,GO:1903825,GO:1905039,GO:1990822		ko:K10016,ko:K10024	ko02010,map02010	M00225,M00226,M00235			ko00000,ko00001,ko00002,ko02000	3.A.1.3.1,3.A.1.3.11		iSbBS512_1146.SbBS512_E2686	Bacteria	1MY2N@1224,1RNYD@1236,3XPAJ@561,COG4215@1,COG4215@2	NA|NA|NA	P	Part of the histidine permease ABC transporter. Also part of a lysine arginine ornithine transporter. Probably responsible for the translocation of the substrate across the membrane. Required to relay the ATPase-inducing signal from the solute-binding protein to HisP (By similarity)
C1_00869	155864.EDL933_3473	2.9e-128	464.5	Escherichia	hisM	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0015711,GO:0015849,GO:0016020,GO:0044464,GO:0046942,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944		ko:K10015	ko02010,map02010	M00225,M00226			ko00000,ko00001,ko00002,ko02000	3.A.1.3.1		iAF1260.b2307,iAPECO1_1312.APECO1_4257,iB21_1397.B21_02192,iBWG_1329.BWG_2081,iE2348C_1286.E2348C_2447,iEC55989_1330.EC55989_2551,iECABU_c1320.ECABU_c26390,iECBD_1354.ECBD_1352,iECB_1328.ECB_02232,iECDH10B_1368.ECDH10B_2469,iECDH1ME8569_1439.ECDH1ME8569_2245,iECD_1391.ECD_02232,iECED1_1282.ECED1_2771,iECH74115_1262.ECH74115_3447,iECIAI1_1343.ECIAI1_2383,iECIAI39_1322.ECIAI39_2456,iECNA114_1301.ECNA114_2397,iECO103_1326.ECO103_2771,iECO111_1330.ECO111_3055,iECO26_1355.ECO26_3295,iECOK1_1307.ECOK1_2540,iECP_1309.ECP_2346,iECS88_1305.ECS88_2454,iECSE_1348.ECSE_2616,iECSF_1327.ECSF_2183,iECSP_1301.ECSP_3182,iECW_1372.ECW_m2496,iECs_1301.ECs3191,iEKO11_1354.EKO11_1458,iETEC_1333.ETEC_2443,iEcDH1_1363.EcDH1_1349,iEcE24377_1341.EcE24377A_2601,iEcSMS35_1347.EcSMS35_2463,iEcolC_1368.EcolC_1345,iG2583_1286.G2583_2844,iJO1366.b2307,iJR904.b2307,iLF82_1304.LF82_1007,iNRG857_1313.NRG857_11685,iSDY_1059.SDY_2506,iSFV_1184.SFV_2374,iSF_1195.SF2383,iSFxv_1172.SFxv_2628,iSSON_1240.SSON_2365,iS_1188.S2518,iSbBS512_1146.SbBS512_E2685,iUMN146_1321.UM146_05275,iUMNK88_1353.UMNK88_2858,iUTI89_1310.UTI89_C2591,iWFL_1372.ECW_m2496,iY75_1357.Y75_RS12100,ic_1306.c2849	Bacteria	1MWI6@1224,1RPT1@1236,3XN40@561,COG4160@1,COG4160@2	NA|NA|NA	E	Part of the histidine permease ABC transporter. Also part of a lysine arginine ornithine transporter. Probably responsible for the translocation of the substrate across the membrane. Required to relay the ATPase-inducing signal from the solute-binding protein to HisP (By similarity)
C1_00870	155864.EDL933_3472	3.9e-139	500.7	Escherichia	hisP	GO:0000166,GO:0003333,GO:0003674,GO:0005215,GO:0005287,GO:0005290,GO:0005291,GO:0005342,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008144,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015174,GO:0015179,GO:0015238,GO:0015318,GO:0015711,GO:0015802,GO:0015807,GO:0015817,GO:0015849,GO:0015893,GO:0016020,GO:0017076,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034220,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0043090,GO:0043167,GO:0043168,GO:0044464,GO:0045117,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0089709,GO:0089718,GO:0097159,GO:0097367,GO:0098655,GO:0098656,GO:0098657,GO:0098739,GO:1901265,GO:1901363,GO:1901474,GO:1902475,GO:1903810,GO:1903825,GO:1905039,GO:1990822	3.6.3.21	ko:K10017	ko02010,map02010	M00225,M00226			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3.1		iECIAI39_1322.ECIAI39_2455,iPC815.YPO2777,iYL1228.KPN_02696,iZ_1308.Z3568	Bacteria	1QTS2@1224,1RQYN@1236,3XP2U@561,COG4598@1,COG4598@2	NA|NA|NA	E	AAA domain, putative AbiEii toxin, Type IV TA system
C1_00871	469008.B21_02190	1.1e-164	585.9	Escherichia	yfcI	GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:1901360											Bacteria	1MUSP@1224,1RNUW@1236,3XM9B@561,COG5464@1,COG5464@2	NA|NA|NA	S	Upon expression enhances RecA-independent DNA recombination 19-fold, concomitantly reducing viability by 98 and inducing DNA damage as measured by induction of the SOS repair response
C1_00872	316407.1799675	1e-170	605.9	Escherichia	yfcH			ko:K07071					ko00000				Bacteria	1MUB4@1224,1RN6A@1236,3XNPS@561,COG1090@1,COG1090@2	NA|NA|NA	S	coenzyme binding
C1_00873	155864.EDL933_3468	1e-60	239.2	Escherichia	folX	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008719,GO:0009987,GO:0016853,GO:0019752,GO:0034641,GO:0042558,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0071704,GO:1901360,GO:1901564	1.13.11.81,4.1.2.25,5.1.99.7,5.1.99.8	ko:K01633,ko:K07589	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073,R11082	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000			iECDH1ME8569_1439.ECDH1ME8569_2955,iECSE_1348.ECSE_3338,iSBO_1134.SBO_2914,iSDY_1059.SDY_3241,iSFxv_1172.SFxv_3403,iUTI89_1310.UTI89_C3494,ic_1306.c3808	Bacteria	1RDHQ@1224,1S4Q3@1236,3XPQY@561,COG1539@1,COG1539@2	NA|NA|NA	H	Catalyzes the epimerization of carbon 2' of the side chain of 7,8-dihydroneopterin triphosphate (H2NTP) to form 7,8- dihydromonapterin triphosphate (H2MTP). Is required for tetrahydromonapterin biosynthesis
C1_00874	316407.1799673	2.3e-124	451.4	Escherichia	yfcG	GO:0003674,GO:0003824,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0015036,GO:0016491,GO:0016667,GO:0050896,GO:0055114		ko:K11209					ko00000,ko01000				Bacteria	1MUN3@1224,1RMF7@1236,3XMUA@561,COG0625@1,COG0625@2	NA|NA|NA	O	Belongs to the GST superfamily
C1_00875	316407.1799672	3.2e-118	431.0	Escherichia	yfcF	GO:0000302,GO:0003674,GO:0003824,GO:0004364,GO:0006950,GO:0006979,GO:0008150,GO:0009636,GO:0010035,GO:0016740,GO:0016765,GO:0042221,GO:0042493,GO:0042542,GO:0046677,GO:0050896,GO:1901700	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418		R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2		iECW_1372.ECW_m2490,iWFL_1372.ECW_m2490	Bacteria	1NX28@1224,1RQUP@1236,3XNIX@561,COG0625@1,COG0625@2	NA|NA|NA	O	however this activity is as low as 1 of that of GstA. Also displays a GSH-dependent peroxidase activity toward cumene hydroperoxide. Is involved in defense against oxidative stress, probably via its peroxidase activity
C1_00876	155864.EDL933_3465	5.2e-101	373.6	Escherichia	yfcE	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008081,GO:0008150,GO:0009987,GO:0016043,GO:0016787,GO:0016788,GO:0022607,GO:0030145,GO:0042578,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071840		ko:K07095					ko00000				Bacteria	1R3Y7@1224,1RY3X@1236,3XMZI@561,COG0622@1,COG0622@2	NA|NA|NA	S	Shows phosphodiesterase activity, hydrolyzing phosphodiesters bonds in the artificial chromogenic substrates bis-p-nitrophenyl phosphate (bis-pNPP), and less efficiently thymidine 5'-monophosphate p-nitrophenyl ester (pNP-TMP) and p- nitrophenylphosphorylcholine (pNPPC). The physiological substrate is
C1_00877	155864.EDL933_3464	2.4e-98	364.8	Escherichia	yfcD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.7.6.2,5.3.3.2	ko:K00949,ko:K01823	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R00619,R01123	RC00002,RC00017,RC00455	ko00000,ko00001,ko00002,ko01000			iJN746.PP_0565	Bacteria	1P8AM@1224,1RQA3@1236,3XNZF@561,COG1443@1,COG1443@2	NA|NA|NA	I	Nudix hydrolase
C1_00878	316407.1799671	3.1e-281	973.8	Escherichia	yfcC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1MY1J@1224,1RS2M@1236,3XQGN@561,COG1288@1,COG1288@2	NA|NA|NA	S	antiporter activity
C1_00879	198214.SF2373	0.0	1370.9	Gammaproteobacteria	pta	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006083,GO:0006084,GO:0006085,GO:0006091,GO:0006113,GO:0006139,GO:0006163,GO:0006164,GO:0006520,GO:0006566,GO:0006567,GO:0006629,GO:0006631,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008959,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009068,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015980,GO:0016053,GO:0016054,GO:0016407,GO:0016740,GO:0016746,GO:0016747,GO:0016999,GO:0017000,GO:0017001,GO:0017144,GO:0018130,GO:0019413,GO:0019427,GO:0019438,GO:0019541,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0042737,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045733,GO:0046390,GO:0046394,GO:0046395,GO:0046459,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0070689,GO:0071616,GO:0071704,GO:0072329,GO:0072330,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606	1.1.1.40,2.3.1.8	ko:K00029,ko:K13788	ko00430,ko00620,ko00640,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00710,map00720,map01100,map01120,map01200	M00169,M00172,M00357,M00579	R00216,R00230,R00921	RC00004,RC00105,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000			iG2583_1286.G2583_2834,iYL1228.KPN_02688	Bacteria	1QTS5@1224,1RMJS@1236,COG0280@1,COG0280@2,COG0857@1,COG0857@2	NA|NA|NA	C	belongs to the CobB CobQ family
C1_00880	155864.EDL933_3461	3e-226	790.8	Escherichia	ackA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006083,GO:0006091,GO:0006113,GO:0006629,GO:0006631,GO:0006633,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0008776,GO:0009058,GO:0009987,GO:0015980,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0016999,GO:0017000,GO:0017144,GO:0019413,GO:0019541,GO:0019542,GO:0019752,GO:0032787,GO:0042710,GO:0043167,GO:0043169,GO:0043436,GO:0044010,GO:0044011,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0046394,GO:0046459,GO:0046872,GO:0046914,GO:0051703,GO:0051704,GO:0051790,GO:0055114,GO:0071704,GO:0072330,GO:0090605,GO:0090609,GO:1901576	2.7.2.1,2.7.2.15	ko:K00925,ko:K00932	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_3309,iECS88_1305.ECS88_3508,iLF82_1304.LF82_2233,iSDY_1059.SDY_2492,iUTI89_1310.UTI89_C3550,iYL1228.KPN_02687	Bacteria	1MW61@1224,1RMKB@1236,3XNFM@561,COG0282@1,COG0282@2	NA|NA|NA	F	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C1_00881	155864.EDL933_3459	2e-82	311.6	Escherichia	yfbV	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0010639,GO:0016020,GO:0033043,GO:0033044,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0065007,GO:0071944,GO:2001251		ko:K09899					ko00000				Bacteria	1N172@1224,1S2QC@1236,3XNMA@561,COG3092@1,COG3092@2	NA|NA|NA	S	UPF0208 membrane protein YfbV
C1_00882	155864.EDL933_3458	3.1e-89	334.3	Escherichia	yfbU	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716		ko:K09161					ko00000				Bacteria	1QWV8@1224,1RME1@1236,3XNF4@561,COG3013@1,COG3013@2	NA|NA|NA	S	Belongs to the UPF0304 family
C1_00883	199310.c2834	7.2e-118	429.9	Escherichia	yfbT	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0030145,GO:0042578,GO:0043136,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050084,GO:0050286,GO:0050308,GO:0050897	3.1.3.23	ko:K19270					ko00000,ko01000				Bacteria	1MX3R@1224,1RPX2@1236,3XNSX@561,COG0637@1,COG0637@2	NA|NA|NA	S	Sugar-phosphate phosphohydrolase that appears to contribute to butanol tolerance. Catalyzes the dephosphorylation of D-mannitol 1-phosphate and D-sorbitol 6- phosphate. Is also able to dephosphorylate other sugar phosphates in vitro including ribose-5-phosphate (Rib5P), 2- deoxyribose-5-phosphate, fructose-1-phosphate (Fru1P), fructose-6- phosphate (Fru6P), and glucose-6-phosphate (Glu6P). Selectively hydrolyzes beta-D-glucose-1- phosphate (bGlu1P) and has no activity with the alpha form
C1_00884	155864.EDL933_3456	0.0	1132.5	Escherichia	yfbS	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03319,ko:K09477,ko:K11106	ko02020,map02020				ko00000,ko00001,ko02000	2.A.47,2.A.47.3.2,2.A.47.3.3		iAF1260.b3063,iBWG_1329.BWG_2774,iECDH10B_1368.ECDH10B_3238,iECDH1ME8569_1439.ECDH1ME8569_2959,iECIAI1_1343.ECIAI1_3211,iETEC_1333.ETEC_3334,iEcDH1_1363.EcDH1_0637,iEcolC_1368.EcolC_0636,iJO1366.b3063,iJR904.b3063,iSSON_1240.SSON_0564,iUMNK88_1353.UMNK88_3815,iY75_1357.Y75_RS15915	Bacteria	1MU0K@1224,1RMI1@1236,3XNMZ@561,COG0471@1,COG0471@2,COG0490@1,COG0490@2	NA|NA|NA	P	potassium ion transport
C1_00885	155864.EDL933_3455	9e-107	392.9	Escherichia	yfbR	GO:0002953,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009157,GO:0009162,GO:0009165,GO:0009176,GO:0009177,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0010139,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019637,GO:0019692,GO:0032262,GO:0034641,GO:0034654,GO:0042578,GO:0042802,GO:0043094,GO:0043167,GO:0043169,GO:0043173,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046078,GO:0046385,GO:0046483,GO:0046872,GO:0046914,GO:0050897,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.1.3.89	ko:K08722	ko00240,ko01100,map00240,map01100		R01569,R01664,R01968,R02088,R02102,R10776	RC00017	ko00000,ko00001,ko01000			iB21_1397.B21_02176,iEC55989_1330.EC55989_2535,iECBD_1354.ECBD_1368,iECB_1328.ECB_02216,iECD_1391.ECD_02216,iECH74115_1262.ECH74115_3430,iECIAI1_1343.ECIAI1_2365,iECIAI39_1322.ECIAI39_2438,iECO111_1330.ECO111_3039,iECO26_1355.ECO26_3279,iECSE_1348.ECSE_2548,iECSP_1301.ECSP_3165,iECUMN_1333.ECUMN_2630,iECs_1301.ECs3175,iEcHS_1320.EcHS_A2440,iEcSMS35_1347.EcSMS35_2446,iEcolC_1368.EcolC_1361,iG2583_1286.G2583_2828,iSFV_1184.SFV_2358,iSF_1195.SF2367,iSFxv_1172.SFxv_2612,iS_1188.S2502,iYL1228.KPN_02681,iZ_1308.Z3552	Bacteria	1MVGJ@1224,1RSED@1236,3XPD7@561,COG1896@1,COG1896@2	NA|NA|NA	F	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
C1_00886	198214.SF2366	1.1e-236	825.5	Gammaproteobacteria	alaA	GO:0003674,GO:0003824,GO:0004021,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006090,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009078,GO:0009079,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016769,GO:0019272,GO:0019752,GO:0019842,GO:0030170,GO:0030632,GO:0032787,GO:0033554,GO:0036094,GO:0040007,GO:0042221,GO:0042851,GO:0042852,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0046677,GO:0047635,GO:0048037,GO:0050662,GO:0050896,GO:0051716,GO:0070279,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.2,2.6.1.66	ko:K00814,ko:K14260	ko00220,ko00250,ko00290,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00220,map00250,map00290,map00710,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00171	R00258,R01215	RC00006,RC00008,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007			iNJ661.Rv0337c	Bacteria	1MW0Z@1224,1RN5B@1236,COG0436@1,COG0436@2	NA|NA|NA	E	in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor'
C1_00887	316407.85675346	1.9e-172	611.7	Escherichia	lrhA	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141											Bacteria	1PR6U@1224,1RQ7J@1236,3XMQ1@561,COG0583@1,COG0583@2	NA|NA|NA	K	Not known, does not seem to act on the proton translocating NADH dehydrogenase genes (nuoA-N) which are part of the lrhA operon
C1_00889	155864.EDL933_3451	6.7e-75	286.6	Escherichia	nuoA	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1		e_coli_core.b2288,iAF1260.b2288,iAPECO1_1312.APECO1_4277,iB21_1397.B21_02173,iBWG_1329.BWG_2062,iE2348C_1286.E2348C_2428,iEC042_1314.EC042_2529,iEC55989_1330.EC55989_2532,iECABU_c1320.ECABU_c26200,iECBD_1354.ECBD_1373,iECB_1328.ECB_02213,iECDH10B_1368.ECDH10B_2450,iECDH1ME8569_1439.ECDH1ME8569_2225,iECD_1391.ECD_02213,iECED1_1282.ECED1_2752,iECH74115_1262.ECH74115_3427,iECIAI1_1343.ECIAI1_2362,iECIAI39_1322.ECIAI39_2435,iECO103_1326.ECO103_2752,iECO26_1355.ECO26_3276,iECOK1_1307.ECOK1_2521,iECP_1309.ECP_2327,iECS88_1305.ECS88_2435,iECSE_1348.ECSE_2545,iECSP_1301.ECSP_3162,iECUMN_1333.ECUMN_2627,iECW_1372.ECW_m2476,iECs_1301.ECs3172,iEKO11_1354.EKO11_1479,iETEC_1333.ETEC_2423,iEcDH1_1363.EcDH1_1369,iEcE24377_1341.EcE24377A_2581,iEcHS_1320.EcHS_A2437,iEcSMS35_1347.EcSMS35_2442,iEcolC_1368.EcolC_1364,iG2583_1286.G2583_2825,iJN746.PP_4119,iJO1366.b2288,iJR904.b2288,iLF82_1304.LF82_1539,iNRG857_1313.NRG857_11585,iSBO_1134.SBO_2321,iSDY_1059.SDY_2484,iSFV_1184.SFV_2355,iSF_1195.SF2364,iSFxv_1172.SFxv_2608,iSSON_1240.SSON_2345,iS_1188.S2499,iSbBS512_1146.SbBS512_E2664,iUMN146_1321.UM146_05375,iUTI89_1310.UTI89_C2568,iWFL_1372.ECW_m2476,iY75_1357.Y75_RS11995,ic_1306.c2829	Bacteria	1RGUT@1224,1S644@1236,3XPK3@561,COG0838@1,COG0838@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1_00890	1440052.EAKF1_ch3694	5.6e-126	456.8	Escherichia	nuoB	GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008137,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034220,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0048037,GO:0050136,GO:0051179,GO:0051234,GO:0051536,GO:0051539,GO:0051540,GO:0055085,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1902600,GO:1990204	1.6.5.3	ko:K00331,ko:K13380	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1		iYL1228.KPN_02677	Bacteria	1MUI2@1224,1RP4R@1236,3XMPW@561,COG0377@1,COG0377@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1_00891	198214.SF2362	0.0	1235.7	Gammaproteobacteria	nuoC	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204	1.6.5.3	ko:K00332,ko:K00333,ko:K13378,ko:K13380	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1		iECDH10B_1368.ECDH10B_2448,iECDH1ME8569_1439.ECDH1ME8569_2223,iETEC_1333.ETEC_2421,iEcDH1_1363.EcDH1_1371,iPC815.YPO2553,iUMNK88_1353.UMNK88_2836	Bacteria	1MVIN@1224,1RM98@1236,COG0649@1,COG0649@2,COG0852@1,COG0852@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1_00892	1440052.EAKF1_ch3696	3e-92	344.4	Escherichia	nuoE	GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0048037,GO:0050136,GO:0051536,GO:0051537,GO:0051540,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1		iYL1228.KPN_02675	Bacteria	1MWS2@1224,1RN4C@1236,3XND0@561,COG1905@1,COG1905@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1_00893	1440052.EAKF1_ch3697	1.6e-265	921.4	Escherichia	nuoF	GO:0000166,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0010181,GO:0015980,GO:0016020,GO:0030964,GO:0032553,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0048037,GO:0050662,GO:0051287,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	1MV8F@1224,1RMUD@1236,3XNXF@561,COG1894@1,COG1894@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C1_00894	155864.EDL933_3446	0.0	1837.0	Escherichia	nuoG	GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0048037,GO:0050136,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1		iECs_1301.ECs3167,iG2583_1286.G2583_2820,iZ_1308.Z3542	Bacteria	1P8MN@1224,1RMUH@1236,3XM7D@561,COG1034@1,COG1034@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1_00895	155864.EDL933_3445	9.9e-180	636.0	Escherichia	nuoH	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Bacteria	1MU2R@1224,1RQE9@1236,3XNZP@561,COG1005@1,COG1005@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C1_00896	1440052.EAKF1_ch3700	3.3e-92	344.4	Escherichia	nuoI	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0030964,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1		e_coli_core.b2281,iAF1260.b2281,iAPECO1_1312.APECO1_4284,iB21_1397.B21_02166,iBWG_1329.BWG_2055,iE2348C_1286.E2348C_2421,iEC042_1314.EC042_2522,iEC55989_1330.EC55989_2525,iECABU_c1320.ECABU_c26130,iECBD_1354.ECBD_1380,iECB_1328.ECB_02206,iECDH10B_1368.ECDH10B_2443,iECDH1ME8569_1439.ECDH1ME8569_2218,iECD_1391.ECD_02206,iECED1_1282.ECED1_2745,iECH74115_1262.ECH74115_3420,iECIAI1_1343.ECIAI1_2355,iECIAI39_1322.ECIAI39_2428,iECNA114_1301.ECNA114_2371,iECO103_1326.ECO103_2745,iECO111_1330.ECO111_3029,iECO26_1355.ECO26_3269,iECOK1_1307.ECOK1_2514,iECP_1309.ECP_2320,iECS88_1305.ECS88_2428,iECSE_1348.ECSE_2538,iECSF_1327.ECSF_2158,iECSP_1301.ECSP_3155,iECUMN_1333.ECUMN_2620,iECW_1372.ECW_m2469,iECs_1301.ECs3165,iEKO11_1354.EKO11_1486,iETEC_1333.ETEC_2416,iEcDH1_1363.EcDH1_1376,iEcE24377_1341.EcE24377A_2574,iEcHS_1320.EcHS_A2430,iEcSMS35_1347.EcSMS35_2435,iEcolC_1368.EcolC_1371,iG2583_1286.G2583_2818,iJO1366.b2281,iJR904.b2281,iLF82_1304.LF82_1546,iNRG857_1313.NRG857_11550,iPC815.YPO2548,iSBO_1134.SBO_2314,iSFV_1184.SFV_2348,iSF_1195.SF2357,iSFxv_1172.SFxv_2601,iS_1188.S2492,iSbBS512_1146.SbBS512_E2657,iUMN146_1321.UM146_05410,iUMNK88_1353.UMNK88_2831,iUTI89_1310.UTI89_C2561,iWFL_1372.ECW_m2469,iY75_1357.Y75_RS11960,iZ_1308.Z3540,ic_1306.c2822	Bacteria	1MV90@1224,1RN32@1236,3XMP4@561,COG1143@1,COG1143@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1_00897	155864.EDL933_3443	4.6e-89	334.0	Escherichia	nuoJ	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1		e_coli_core.b2280,iAF1260.b2280,iAPECO1_1312.APECO1_4285,iB21_1397.B21_02165,iBWG_1329.BWG_2054,iE2348C_1286.E2348C_2420,iEC042_1314.EC042_2521,iEC55989_1330.EC55989_2524,iECABU_c1320.ECABU_c26120,iECBD_1354.ECBD_1381,iECB_1328.ECB_02205,iECDH10B_1368.ECDH10B_2442,iECDH1ME8569_1439.ECDH1ME8569_2217,iECD_1391.ECD_02205,iECED1_1282.ECED1_2744,iECH74115_1262.ECH74115_3419,iECIAI1_1343.ECIAI1_2354,iECIAI39_1322.ECIAI39_2427,iECNA114_1301.ECNA114_2370,iECO103_1326.ECO103_2744,iECO111_1330.ECO111_3028,iECO26_1355.ECO26_3268,iECOK1_1307.ECOK1_2513,iECP_1309.ECP_2319,iECS88_1305.ECS88_2427,iECSE_1348.ECSE_2537,iECSF_1327.ECSF_2157,iECSP_1301.ECSP_3154,iECUMN_1333.ECUMN_2619,iECW_1372.ECW_m2468,iECs_1301.ECs3164,iEKO11_1354.EKO11_1487,iETEC_1333.ETEC_2415,iEcDH1_1363.EcDH1_1377,iEcE24377_1341.EcE24377A_2573,iEcHS_1320.EcHS_A2429,iEcSMS35_1347.EcSMS35_2434,iEcolC_1368.EcolC_1372,iJO1366.b2280,iJR904.b2280,iLF82_1304.LF82_1547,iNRG857_1313.NRG857_11545,iSBO_1134.SBO_2313,iSDY_1059.SDY_2476,iSFV_1184.SFV_2347,iSF_1195.SF2356,iSFxv_1172.SFxv_2600,iSSON_1240.SSON_2337,iS_1188.S2491,iSbBS512_1146.SbBS512_E2656,iUMN146_1321.UM146_05415,iUMNK88_1353.UMNK88_2830,iUTI89_1310.UTI89_C2560,iWFL_1372.ECW_m2468,iY75_1357.Y75_RS11955,iZ_1308.Z3539,ic_1306.c2821	Bacteria	1MWJV@1224,1S65T@1236,3XMGS@561,COG0839@1,COG0839@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1_00898	1080067.BAZH01000028_gene1119	1.3e-42	178.7	Citrobacter	nuoK	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1		iIT341.HP1270	Bacteria	1RH0S@1224,1S6FN@1236,3WYKT@544,COG0713@1,COG0713@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1_00899	199310.c2819	0.0	1180.6	Escherichia	nuoL	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015672,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0051179,GO:0051234,GO:0055085,GO:0070469,GO:0070470,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1902600,GO:1990204	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1		e_coli_core.b2278,iAF1260.b2278,iBWG_1329.BWG_2052,iECDH10B_1368.ECDH10B_2440,iECDH1ME8569_1439.ECDH1ME8569_2215,iEcDH1_1363.EcDH1_1379,iJN746.PP_4129,iJO1366.b2278,iJR904.b2278,iY75_1357.Y75_RS11945	Bacteria	1MW2M@1224,1RNKN@1236,3XNJM@561,COG1009@1,COG1009@2	NA|NA|NA	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus
C1_00900	155864.EDL933_3440	1.1e-286	991.9	Escherichia	nuoM	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0048037,GO:0048038,GO:0048039,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1902600,GO:1990204	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1		iSDY_1059.SDY_2473	Bacteria	1MV7V@1224,1RNI4@1236,3XMB8@561,COG1008@1,COG1008@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1_00901	155864.EDL933_3439	2e-261	907.9	Escherichia	nuoN	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008137,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1902600,GO:1990204	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1		iEC042_1314.EC042_2517,iSbBS512_1146.SbBS512_E2652	Bacteria	1MV56@1224,1RPJB@1236,3XN8H@561,COG1007@1,COG1007@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1_00902	469008.B21_02158	5.4e-89	333.6	Escherichia	yfbM												Bacteria	1NADM@1224,1SFMG@1236,29094@1,2ZMYT@2,3XNXP@561	NA|NA|NA	S	Domain of unknown function (DUF1877)
C1_00903	469008.B21_02155	5e-213	746.9	Gammaproteobacteria	elaD	GO:0003674,GO:0003824,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008234,GO:0009987,GO:0016579,GO:0016787,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0070011,GO:0070646,GO:0070647,GO:0071704,GO:0140096,GO:1901564		ko:K18015,ko:K18879	ko04626,map04626				ko00000,ko00001,ko01000,ko01002				Bacteria	1N09I@1224,1SC0W@1236,COG5160@1,COG5160@2	NA|NA|NA	O	Protease that can act as an efficient and specific deubiquitinating enzyme in vitro. Does not possess desumoylating and deneddylating activities. The physiological substrate is
C1_00904	198214.SF2347	1.6e-176	625.2	Gammaproteobacteria	rnz	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004527,GO:0004532,GO:0004540,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016891,GO:0016893,GO:0016896,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0042779,GO:0042780,GO:0042781,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0090503,GO:0140098,GO:1901360,GO:1905267	3.1.26.11	ko:K00784	ko03013,map03013				ko00000,ko00001,ko01000,ko03016				Bacteria	1Q4PW@1224,1RR5K@1236,COG1234@1,COG1234@2	NA|NA|NA	S	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
C1_00905	198214.SF2346	4.3e-85	320.5	Gammaproteobacteria	elaA	GO:0003674,GO:0003824,GO:0006464,GO:0006473,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564		ko:K02348					ko00000				Bacteria	1MZHA@1224,1S9IF@1236,COG2153@1,COG2153@2	NA|NA|NA	S	Acyltransferase
C1_00906	155864.EDL933_3432	1.6e-48	198.4	Escherichia	elaB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033554,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0071944		ko:K05594,ko:K07184					ko00000				Bacteria	1RIDP@1224,1S68F@1236,3XPV9@561,COG4575@1,COG4575@2	NA|NA|NA	S	ribosome binding
C1_00907	316407.1799622	1.2e-249	868.6	Escherichia	menF	GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004049,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008909,GO:0009058,GO:0009072,GO:0009073,GO:0009108,GO:0009233,GO:0009234,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016833,GO:0016853,GO:0016866,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042180,GO:0042181,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0046872,GO:0050486,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901661,GO:1901663,GO:1902494	5.4.4.2	ko:K02361,ko:K02552	ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130	M00116	R01717	RC00588	ko00000,ko00001,ko00002,ko01000			iECABU_c1320.ECABU_c26010,iECIAI39_1322.ECIAI39_2413,iSF_1195.SF2344,iS_1188.S2478,ic_1306.c2809	Bacteria	1MVB7@1224,1RNSR@1236,3XPGQ@561,COG1169@1,COG1169@2	NA|NA|NA	H	Catalyzes the conversion of chorismate to isochorismate
C1_00908	198214.SF2343	0.0	1119.8	Gammaproteobacteria	menD	GO:0003674,GO:0003824,GO:0005488,GO:0006732,GO:0008150,GO:0008152,GO:0008683,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016833,GO:0019842,GO:0030976,GO:0036094,GO:0042180,GO:0042181,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070204,GO:0071704,GO:0097159,GO:1901363,GO:1901576,GO:1901661,GO:1901663,GO:1901681	2.2.1.9	ko:K02551	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08165	RC02186	ko00000,ko00001,ko00002,ko01000			iSBO_1134.SBO_2301	Bacteria	1MVMZ@1224,1RNRS@1236,COG1165@1,COG1165@2	NA|NA|NA	H	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C1_00909	316407.85675331	2.2e-142	511.5	Escherichia	menH	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016787,GO:0016829,GO:0016835,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0070205,GO:0071704,GO:1901576,GO:1901661,GO:1901663	4.2.99.20	ko:K08680	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08166	RC02148,RC02475	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_4298,iEC55989_1330.EC55989_2511,iECO103_1326.ECO103_2730,iECOK1_1307.ECOK1_2500,iECS88_1305.ECS88_2414,iETEC_1333.ETEC_2398,iEcE24377_1341.EcE24377A_2559,iSBO_1134.SBO_2300,iUMN146_1321.UM146_05480,iUTI89_1310.UTI89_C2547	Bacteria	1R3WK@1224,1RQHH@1236,3XNH0@561,COG0596@1,COG0596@2	NA|NA|NA	H	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC)
C1_00910	199310.c2805	5.5e-166	590.1	Escherichia	menB	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0008150,GO:0008152,GO:0008935,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0042180,GO:0042181,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:0071890,GO:1901576,GO:1901661,GO:1901663	4.1.3.36	ko:K01661	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R07263	RC01923	ko00000,ko00001,ko00002,ko01000			iJN678.menB,iYL1228.KPN_02660	Bacteria	1QTZ2@1224,1T1TZ@1236,3XMUF@561,COG0447@1,COG0447@2	NA|NA|NA	H	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C1_00911	155864.EDL933_3427	2.7e-182	644.4	Escherichia	menC	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	4.2.1.113	ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04031	RC01053	ko00000,ko00001,ko00002,ko01000			iE2348C_1286.E2348C_2406,iSbBS512_1146.SbBS512_E2640	Bacteria	1MV33@1224,1RRC0@1236,3XNDA@561,COG1441@1,COG1441@2	NA|NA|NA	H	Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)
C1_00912	481805.EcolC_1388	2.9e-262	910.6	Escherichia	menE	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006732,GO:0008150,GO:0008152,GO:0008756,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016043,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0022607,GO:0042180,GO:0042181,GO:0042802,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901576,GO:1901661,GO:1901663	4.2.1.113,6.2.1.26	ko:K01911,ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04030,R04031	RC00004,RC00014,RC01053	ko00000,ko00001,ko00002,ko01000			iECNA114_1301.ECNA114_2354,iECSF_1327.ECSF_2141,iEcE24377_1341.EcE24377A_2556,iEcHS_1320.EcHS_A2406,iJN678.menE,iLF82_1304.LF82_1314,iNRG857_1313.NRG857_11465	Bacteria	1MW0Y@1224,1RN35@1236,3XNGV@561,COG0318@1,COG0318@2	NA|NA|NA	H	Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily
C1_00913	316407.85675329	5.3e-43	179.9	Escherichia	pmrD			ko:K19238	ko01503,map01503				ko00000,ko00001				Bacteria	1NBZ4@1224,1SDH3@1236,2EDNI@1,337I9@2,3XR5G@561	NA|NA|NA	S	Interacts with phosphorylated BasR protein to mediate transcriptional induction of BasR-activated genes to induce polymyxin resistance in some natural isolates
C1_00914	155864.EDL933_3424	8.7e-63	246.1	Escherichia	arnF	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0010035,GO:0010038,GO:0010039,GO:0010041,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0042221,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944		ko:K12962,ko:K12963	ko01503,map01503	M00721			ko00000,ko00001,ko00002,ko01005,ko02000	2.A.7,2.A.7.22		iEC55989_1330.EC55989_2505,iECUMN_1333.ECUMN_2601,iSF_1195.SF2337,iS_1188.S2471	Bacteria	1N7ZX@1224,1SCDW@1236,3XPPS@561,COG2076@1,COG2076@2	NA|NA|NA	P	Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane
C1_00915	316407.85675327	2e-55	221.5	Escherichia	arnE	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0010035,GO:0010038,GO:0010039,GO:0010041,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0042221,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944		ko:K03297,ko:K12962,ko:K12963	ko01503,map01503	M00721			ko00000,ko00001,ko00002,ko01005,ko02000	2.A.7,2.A.7.1,2.A.7.22		iEC55989_1330.EC55989_2505,iECABU_c1320.ECABU_c25920,iECUMN_1333.ECUMN_2601,iLF82_1304.LF82_3058,iNRG857_1313.NRG857_11450,ic_1306.c2800	Bacteria	1MY82@1224,1SYBA@1236,3XPW7@561,COG2076@1,COG2076@2	NA|NA|NA	P	Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane
C1_00916	316407.85675326	0.0	1093.2	Escherichia	arnT	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0010041,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016763,GO:0033692,GO:0034637,GO:0034645,GO:0042221,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0050896,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.2.43	ko:K07264	ko01503,map01503	M00721	R09773,R09774,R09781	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005			iEcHS_1320.EcHS_A2402	Bacteria	1NMIZ@1224,1RMA2@1236,3XN53@561,COG1807@1,COG1807@2	NA|NA|NA	I	Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides
C1_00917	316407.85675325	6.7e-175	619.8	Escherichia	arnD	GO:0005575,GO:0008150,GO:0010035,GO:0010038,GO:0010039,GO:0010041,GO:0016020,GO:0042221,GO:0050896		ko:K13014	ko00520,ko01503,map00520,map01503	M00721,M00761	R07662	RC00323,RC01575	ko00000,ko00001,ko00002,ko01000,ko01005			iAF987.Gmet_0882,iB21_1397.B21_02141,iBWG_1329.BWG_2029,iEC042_1314.EC042_2499,iECBD_1354.ECBD_1403,iECB_1328.ECB_02182,iECDH10B_1368.ECDH10B_2416,iECDH1ME8569_1439.ECDH1ME8569_2192,iECD_1391.ECD_02182,iECO103_1326.ECO103_2722,iECO111_1330.ECO111_3006,iECO26_1355.ECO26_3246,iECUMN_1333.ECUMN_2597,iECW_1372.ECW_m2447,iEKO11_1354.EKO11_1508,iETEC_1333.ETEC_2390,iEcDH1_1363.EcDH1_1402,iEcHS_1320.EcHS_A2401,iEcolC_1368.EcolC_1393,iJO1366.b2256,iSFV_1184.SFV_2326,iSSON_1240.SSON_2317,iUMNK88_1353.UMNK88_2808,iWFL_1372.ECW_m2447,iY75_1357.Y75_RS11830	Bacteria	1N8Q4@1224,1RQ0R@1236,3XPB4@561,COG0726@1,COG0726@2	NA|NA|NA	G	Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides
C1_00918	155864.EDL933_3420	0.0	1358.6	Escherichia	arnA	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006040,GO:0006139,GO:0006725,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016741,GO:0016742,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0022607,GO:0033319,GO:0033320,GO:0034214,GO:0034641,GO:0034654,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046349,GO:0046483,GO:0046677,GO:0048037,GO:0048040,GO:0050662,GO:0050896,GO:0051259,GO:0051287,GO:0055086,GO:0055114,GO:0065003,GO:0070403,GO:0071704,GO:0071840,GO:0097159,GO:0099618,GO:0099619,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:2001313,GO:2001315	1.1.1.305,2.1.2.13,2.1.2.9,5.1.3.2	ko:K00604,ko:K01784,ko:K10011,ko:K12449,ko:K21332	ko00052,ko00520,ko00523,ko00670,ko00970,ko01100,ko01130,ko01503,map00052,map00520,map00523,map00670,map00970,map01100,map01130,map01503	M00361,M00362,M00632,M00721,M00761	R00291,R01384,R01386,R02984,R03940,R07658,R07660,R11472	RC00026,RC00165,RC00289,RC00508,RC01575,RC01811,RC01812	ko00000,ko00001,ko00002,ko01000,ko01005			iPC815.YPO2420,iSFV_1184.SFV_2325	Bacteria	1MXKV@1224,1RNJD@1236,3XPGM@561,COG0223@1,COG0223@2,COG0451@1,COG0451@2	NA|NA|NA	I	Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides
C1_00919	316407.1799606	7e-178	629.8	Escherichia	arnC	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0044464,GO:0071944,GO:0099621	2.4.2.53	ko:K10012	ko00520,ko01503,map00520,map01503	M00721,M00761	R07661	RC00005,RC02954	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.2.1.8	GT2	iAPECO1_1312.APECO1_4307,iE2348C_1286.E2348C_2398,iECABU_c1320.ECABU_c25880,iECED1_1282.ECED1_2720,iECOK1_1307.ECOK1_2490,iECP_1309.ECP_2297,iECS88_1305.ECS88_2403,iLF82_1304.LF82_0138,iNRG857_1313.NRG857_11430,iUMN146_1321.UM146_05530,iUTI89_1310.UTI89_C2536,ic_1306.c2796	Bacteria	1MWE5@1224,1RPCE@1236,3XPBE@561,COG0463@1,COG0463@2	NA|NA|NA	I	Catalyzes the transfer of 4-deoxy-4-formamido-L- arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides
C1_00920	316407.85675324	4.6e-216	756.9	Escherichia	arnB	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008144,GO:0008483,GO:0016740,GO:0016769,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:0099620,GO:1901363	2.6.1.87	ko:K07806	ko00520,ko01503,ko02020,map00520,map01503,map02020	M00721,M00761	R07659	RC00006,RC01514	ko00000,ko00001,ko00002,ko01000,ko01005,ko01007			iSFxv_1172.SFxv_2574	Bacteria	1MUPN@1224,1RMCS@1236,3XMQ3@561,COG0399@1,COG0399@2	NA|NA|NA	M	Catalyzes the conversion of UDP-4-keto-arabinose (UDP- Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides
C1_00921	199310.c2794	2.3e-110	404.8	Escherichia	ais		5.4.2.12	ko:K15634	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000				Bacteria	1R8NR@1224,1S1BP@1236,3XNTM@561,COG0406@1,COG0406@2	NA|NA|NA	M	Catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core
C1_00922	316407.1799603	3.8e-75	287.3	Escherichia	nudI	GO:0003674,GO:0003824,GO:0004170,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0047429,GO:0047840		ko:K12944					ko00000,ko01000			iECABU_c1320.ECABU_c25850,iECED1_1282.ECED1_2717,iECP_1309.ECP_2294,iECSF_1327.ECSF_2131,ic_1306.c2793	Bacteria	1R9WD@1224,1S3YH@1236,3XPRF@561,COG0494@1,COG0494@2	NA|NA|NA	L	Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP)
C1_00923	316407.85675323	3.4e-97	360.9	Escherichia	yfaZ	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944											Bacteria	1RDW5@1224,1S3Q0@1236,29PXB@1,30AVP@2,3XMZE@561	NA|NA|NA	S	YfaZ precursor
C1_00924	316407.1799602	4.6e-227	793.5	Escherichia	cinA	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	3.5.1.42	ko:K03742	ko00760,map00760		R02322	RC00100	ko00000,ko00001,ko01000				Bacteria	1QUB2@1224,1RNXG@1236,3XN9H@561,COG1058@1,COG1058@2	NA|NA|NA	S	Probable molybdopterin binding domain
C1_00925	199310.c2790	4.5e-21	107.1	Escherichia	rhmR	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K10973,ko:K13641,ko:K19333					ko00000,ko03000				Bacteria	1R5G3@1224,1RSB1@1236,3XP94@561,COG1414@1,COG1414@2	NA|NA|NA	K	Transcriptional regulator
C1_00926	471874.PROSTU_00611	3.3e-71	274.2	Providencia				ko:K07491					ko00000				Bacteria	1RDD7@1224,1S4R2@1236,3ZAC3@586,COG1943@1,COG1943@2	NA|NA|NA	L	COG1943 Transposase and inactivated derivatives
C1_00927	61647.LG71_25300	8.2e-205	719.5	Gammaproteobacteria				ko:K07496					ko00000				Bacteria	1MUU0@1224,1RS1J@1236,COG0675@1,COG0675@2	NA|NA|NA	L	Transposase
C1_00928	316407.1799601	4.5e-50	203.8	Escherichia	rhmR	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032774,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K10973,ko:K13641,ko:K19333					ko00000,ko03000				Bacteria	1R5G3@1224,1RSB1@1236,3XP94@561,COG1414@1,COG1414@2	NA|NA|NA	K	Transcriptional regulator
C1_00929	199310.c2788	2.1e-191	674.9	Escherichia	rhmT	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944										iAPECO1_1312.APECO1_4315,iUTI89_1310.UTI89_C2528,ic_1306.c2788	Bacteria	1MUEK@1224,1RMB4@1236,3XNKV@561,COG2271@1,COG2271@2	NA|NA|NA	P	transmembrane transport
C1_00930	199310.c2787	6.3e-148	530.0	Escherichia	rhmA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0016151,GO:0016829,GO:0016830,GO:0016832,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0071704	4.1.2.20,4.1.2.52,4.1.2.53	ko:K01630,ko:K02510,ko:K12660	ko00051,ko00053,ko00350,ko01120,map00051,map00053,map00350,map01120		R01645,R01647,R02261,R02754,R03277	RC00307,RC00435,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_3301,iE2348C_1286.E2348C_3412,iEC042_1314.EC042_3416,iEC55989_1330.EC55989_3544,iECIAI1_1343.ECIAI1_3274,iECIAI39_1322.ECIAI39_3625,iECNA114_1301.ECNA114_3207,iECO103_1326.ECO103_3871,iECO26_1355.ECO26_4229,iECOK1_1307.ECOK1_3549,iECP_1309.ECP_3216,iECS88_1305.ECS88_3514,iECSE_1348.ECSE_3410,iECSF_1327.ECSF_2962,iECUMN_1333.ECUMN_3608,iECW_1372.ECW_m3394,iECs_1301.ECs4004,iEKO11_1354.EKO11_0593,iEcE24377_1341.EcE24377A_3604,iEcSMS35_1347.EcSMS35_3421,iG2583_1286.G2583_3848,iLF82_1304.LF82_0805,iNRG857_1313.NRG857_15525,iSBO_1134.SBO_2049,iSBO_1134.SBO_2991,iUMN146_1321.UM146_00720,iUTI89_1310.UTI89_C3557,iWFL_1372.ECW_m3394,iZ_1308.Z4478	Bacteria	1MUSG@1224,1RMWJ@1236,3XNDD@561,COG3836@1,COG3836@2	NA|NA|NA	H	Catalyzes the reversible retro-aldol cleavage of 2-keto- 3-deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde
C1_00931	199310.c2786	7.1e-21	105.9	Escherichia	yfaD												Bacteria	1MUSP@1224,1RNUW@1236,3XNSZ@561,COG5464@1,COG5464@2	NA|NA|NA	S	Putative transposase, YhgA-like
C1_00932	481805.EcolC_1406	6.4e-163	580.1	Escherichia	yfaD												Bacteria	1MUSP@1224,1RNUW@1236,3XNSZ@561,COG5464@1,COG5464@2	NA|NA|NA	S	Putative transposase, YhgA-like
C1_00933	362663.ECP_2285	1.5e-225	788.5	Escherichia	glpC	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0045333,GO:0046872,GO:0048037,GO:0051536,GO:0051540,GO:0055114,GO:0071944	1.1.5.3	ko:K00113	ko00564,ko01110,map00564,map01110		R00848	RC00029	ko00000,ko00001,ko01000				Bacteria	1MWTK@1224,1RQ9M@1236,3XP8B@561,COG0247@1,COG0247@2	NA|NA|NA	C	Anaerobic glycerol-3-phosphate dehydrogenase subunit C
C1_00934	199310.c2783	1.1e-239	835.5	Escherichia	glpB	GO:0000166,GO:0003674,GO:0003824,GO:0004368,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006072,GO:0006091,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009061,GO:0009987,GO:0010181,GO:0015980,GO:0016020,GO:0016491,GO:0016614,GO:0016901,GO:0019637,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046168,GO:0046434,GO:0048037,GO:0050662,GO:0052646,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:1901135,GO:1901136,GO:1901265,GO:1901363,GO:1901575	1.1.5.3	ko:K00112	ko00564,ko01110,map00564,map01110		R00848	RC00029	ko00000,ko00001,ko01000			iB21_1397.B21_02127,iEC042_1314.EC042_2485,iECBD_1354.ECBD_1418,iECB_1328.ECB_02168,iECD_1391.ECD_02168,iECUMN_1333.ECUMN_2582,iEcHS_1320.EcHS_A2383,iUMNK88_1353.UMNK88_2792	Bacteria	1MU3K@1224,1RP77@1236,3XN7A@561,COG3075@1,COG3075@2	NA|NA|NA	C	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
C1_00935	155864.EDL933_3405	0.0	1081.2	Escherichia	glpA	GO:0000166,GO:0003674,GO:0003824,GO:0004368,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006072,GO:0006091,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016614,GO:0016901,GO:0019637,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046168,GO:0046434,GO:0048037,GO:0050660,GO:0050662,GO:0052646,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:1901135,GO:1901136,GO:1901265,GO:1901363,GO:1901575	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110		R00848	RC00029	ko00000,ko00001,ko01000			iSDY_1059.SDY_2436	Bacteria	1MUMY@1224,1RUEK@1236,3XMZ8@561,COG0578@1,COG0578@2	NA|NA|NA	C	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
C1_00936	155864.EDL933_3404	8.4e-262	909.1	Escherichia	glpT	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0008509,GO:0008643,GO:0015075,GO:0015103,GO:0015114,GO:0015144,GO:0015166,GO:0015168,GO:0015291,GO:0015297,GO:0015301,GO:0015315,GO:0015318,GO:0015527,GO:0015698,GO:0015711,GO:0015748,GO:0015791,GO:0015793,GO:0015794,GO:0015850,GO:0016020,GO:0022804,GO:0022857,GO:0034219,GO:0034220,GO:0035435,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:0099516,GO:1901264,GO:1901618		ko:K02445					ko00000,ko02000	2.A.1.4.3		iECH74115_1262.ECH74115_3377,iECIAI39_1322.ECIAI39_2383,iECSP_1301.ECSP_3115,iECs_1301.ECs3125,iEcSMS35_1347.EcSMS35_2392,iG2583_1286.G2583_2780,iSFV_1184.SFV_2312,iZ_1308.Z3498	Bacteria	1MX4V@1224,1RMB3@1236,3XNBI@561,COG2271@1,COG2271@2	NA|NA|NA	P	glycerol-phosphate:inorganic phosphate antiporter activity
C1_00937	155864.EDL933_3403	1.9e-208	731.5	Escherichia	glpQ	GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0008081,GO:0008889,GO:0009279,GO:0016020,GO:0016787,GO:0016788,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0042578,GO:0042597,GO:0043167,GO:0043169,GO:0044462,GO:0044464,GO:0046872,GO:0071944	3.1.4.46	ko:K01126	ko00564,map00564		R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000			iECNA114_1301.ECNA114_2331,iECSF_1327.ECSF_2119	Bacteria	1MVWZ@1224,1RRBP@1236,3XP14@561,COG0584@1,COG0584@2	NA|NA|NA	C	glycerophosphoryl diester phosphodiesterase
C1_00938	155864.EDL933_3400	2.5e-134	485.0	Gammaproteobacteria	yfaH												Bacteria	1R5RF@1224,1RYQ5@1236,COG0583@1,COG0583@2	NA|NA|NA	K	transcriptional regulator
C1_00939	155864.EDL933_3399	3.9e-213	747.3	Gammaproteobacteria													Bacteria	1RB5E@1224,1RYS9@1236,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
C1_00940	155864.EDL933_3398	5.3e-121	440.3	Escherichia	inaA		2.7.11.1,3.6.1.27	ko:K02848,ko:K07178,ko:K19302	ko00540,ko00550,ko01100,ko03008,map00540,map00550,map01100,map03008	M00080	R05627	RC00002	ko00000,ko00001,ko00002,ko01000,ko01001,ko01005,ko01011,ko03009				Bacteria	1N21R@1224,1RYF7@1236,3XQEJ@561,COG3642@1,COG3642@2	NA|NA|NA	T	May be an environmental sensor responsive to several stimuli, including internal pH, proton motive force, temperature, and possibly other
C1_00941	199310.c2778	1.7e-43	181.4	Escherichia	yfaE	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006091,GO:0006124,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0019538,GO:0022900,GO:0030091,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0048037,GO:0051536,GO:0051537,GO:0051540,GO:0055114,GO:0071704,GO:1901564		ko:K11107					ko00000				Bacteria	1N6XY@1224,1SC8M@1236,3XPYF@561,COG1018@1,COG1018@2	NA|NA|NA	C	ferredoxin metabolic process
C1_00942	155864.EDL933_3396	4.5e-216	756.9	Escherichia	nrdB	GO:0003674,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0015949,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0034654,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990204	1.17.4.1	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400			iAPECO1_1312.APECO1_4325,iSFV_1184.SFV_2827,iSF_1195.SF2704,iSFxv_1172.SFxv_2966,iS_1188.S2890	Bacteria	1MWUS@1224,1RMJC@1236,3XMHI@561,COG0208@1,COG0208@2	NA|NA|NA	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R2 contains the tyrosyl radical required for catalysis
C1_00943	316407.1799581	0.0	1436.0	Escherichia	nrdA	GO:0000166,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0015949,GO:0016491,GO:0016725,GO:0016728,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990204	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400			iSDY_1059.SDY_2428	Bacteria	1MUJ8@1224,1RMPV@1236,3XP46@561,COG0209@1,COG0209@2	NA|NA|NA	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1_00944	316407.85675321	0.0	2152.5	Escherichia	yfaL	GO:0005575,GO:0005576,GO:0005623,GO:0007155,GO:0008150,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009986,GO:0009987,GO:0022610,GO:0031589,GO:0042597,GO:0042710,GO:0043708,GO:0043709,GO:0044010,GO:0044464,GO:0044764,GO:0050896,GO:0051704,GO:0090605,GO:0090609		ko:K07279					ko00000,ko02000,ko02044	1.B.12			Bacteria	1R9B8@1224,1S1YA@1236,3XQFF@561,COG3468@1,COG3468@2	NA|NA|NA	MU	cell adhesion involved in single-species biofilm formation
C1_00945	316407.1799576	1.9e-135	488.4	Escherichia	ubiG	GO:0003674,GO:0003824,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008289,GO:0008689,GO:0008757,GO:0009058,GO:0009108,GO:0009628,GO:0009651,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0042180,GO:0042181,GO:0042538,GO:0043167,GO:0043168,GO:0043431,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0051188,GO:0061542,GO:0071704,GO:1901576,GO:1901611,GO:1901661,GO:1901663	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000			iE2348C_1286.E2348C_2376	Bacteria	1MU89@1224,1RMV7@1236,3XMKY@561,COG2227@1,COG2227@2	NA|NA|NA	H	O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway
C1_00946	198214.SF2311	0.0	1602.8	Gammaproteobacteria	gyrA	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0018130,GO:0019438,GO:0032774,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042493,GO:0042623,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097659,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576	5.99.1.3	ko:K02469,ko:K02621					ko00000,ko01000,ko02048,ko03032,ko03036,ko03400				Bacteria	1MUGG@1224,1RN03@1236,COG0188@1,COG0188@2	NA|NA|NA	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C1_00947	316407.1799574	0.0	1086.6	Escherichia	yfaA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Bacteria	1MY31@1224,1S1N1@1236,3XNSJ@561,COG4685@1,COG4685@2	NA|NA|NA	S	Uncharacterized protein conserved in bacteria (DUF2138)
C1_00948	155864.EDL933_3390	3.6e-119	434.1	Escherichia	yfaT			ko:K09934					ko00000				Bacteria	1R6VA@1224,1RXXS@1236,3XNZE@561,COG3234@1,COG3234@2	NA|NA|NA	S	Protein of unknown function (DUF1175)
C1_00949	362663.ECP_2271	0.0	2841.6	Escherichia	yfaS			ko:K06894					ko00000				Bacteria	1MV7J@1224,1S1TU@1236,3XMWZ@561,COG2373@1,COG2373@2	NA|NA|NA	S	Alpha-2-Macroglobulin
C1_00950	198214.SF2304	0.0	1082.4	Gammaproteobacteria	yfaQ												Bacteria	1QBHH@1224,1S0FA@1236,COG5445@1,COG5445@2	NA|NA|NA	S	Stage II sporulation protein
C1_00951	155864.EDL933_3386	7e-144	516.5	Escherichia	yfaP												Bacteria	1R801@1224,1SYU2@1236,3XRI7@561,COG4676@1,COG4676@2	NA|NA|NA	S	Uncharacterized protein conserved in bacteria (DUF2135)
C1_00953	481805.EcolC_1432	0.0	1853.6	Escherichia	rcsC	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006970,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009628,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0033554,GO:0035556,GO:0036211,GO:0042710,GO:0043170,GO:0043412,GO:0044010,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0044764,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051716,GO:0065007,GO:0071214,GO:0071470,GO:0071704,GO:0071944,GO:0104004,GO:0140096,GO:1901564	2.7.13.3	ko:K07677,ko:K07679	ko02020,ko02026,ko05133,map02020,map02026,map05133	M00474,M00477			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	1NRP8@1224,1RQCU@1236,3XMTU@561,COG0642@1,COG0784@1,COG0784@2,COG2205@2	NA|NA|NA	T	PhoQ Sensor
C1_00954	1114922.CIFAM_02_01580	6.3e-114	416.8	Citrobacter	rcsB	GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001141,GO:0001216,GO:0001217,GO:0003674,GO:0003700,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031344,GO:0031346,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042710,GO:0043170,GO:0044010,GO:0044011,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0046677,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051703,GO:0051704,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090605,GO:0090609,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141		ko:K02282,ko:K07686,ko:K07687,ko:K07689,ko:K07690,ko:K20264	ko02020,ko02024,ko02025,ko02026,ko05111,ko05133,map02020,map02024,map02025,map02026,map05111,map05133	M00473,M00474,M00475,M00477,M00697,M00818			ko00000,ko00001,ko00002,ko01504,ko02022,ko02035,ko02044				Bacteria	1MW84@1224,1RNK3@1236,3WXP4@544,COG2197@1,COG2197@2	NA|NA|NA	K	Component of the Rcs signaling system, which controls transcription of numerous genes. RcsB is the response regulator that binds to regulatory DNA regions
C1_00955	155864.EDL933_3383	0.0	1722.6	Escherichia	rcsD	GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009927,GO:0009987,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0031224,GO:0031226,GO:0035556,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.7.13.3,4.6.1.1	ko:K01768,ko:K07676,ko:K07687,ko:K10715,ko:K20976	ko00230,ko02020,ko02024,ko02025,ko02026,ko04113,ko04213,map00230,map02020,map02024,map02025,map02026,map04113,map04213	M00474,M00517,M00695,M00820	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	1MXQG@1224,1RQ18@1236,3XNSS@561,COG0642@1,COG0642@2,COG2198@1,COG2198@2	NA|NA|NA	T	Component of the Rcs signaling system, which controls transcription of numerous genes. RcsD is a phosphotransfer intermediate between the sensor kinase RcsC and the response regulator RcsB. It acquires a phosphoryl group from RcsC and transfers it to RcsB
C1_00956	481805.EcolC_1435	6.4e-207	726.5	Escherichia	ompC	GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0006869,GO:0006950,GO:0006974,GO:0008150,GO:0009279,GO:0009987,GO:0010876,GO:0015711,GO:0015748,GO:0015914,GO:0016020,GO:0016021,GO:0019867,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031975,GO:0033036,GO:0033554,GO:0044425,GO:0044462,GO:0044464,GO:0045203,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0071702,GO:0071944		ko:K09475	ko01501,ko02020,map01501,map02020				ko00000,ko00001,ko02000	1.B.1.1.3		iEC042_1314.EC042_2456,iUMNK88_1353.UMNK88_2764	Bacteria	1MVRY@1224,1RNBS@1236,3XPDX@561,COG3203@1,COG3203@2	NA|NA|NA	M	Forms pores that allow passive diffusion of small molecules across the outer membrane
C1_00957	198214.SF2298	3.3e-197	694.1	Gammaproteobacteria	apbE	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016740,GO:0017013,GO:0019538,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0031975,GO:0036094,GO:0036211,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0071944,GO:0071949,GO:0097159,GO:0098552,GO:0098567,GO:1901265,GO:1901363,GO:1901564	2.7.1.180	ko:K03734					ko00000,ko01000				Bacteria	1MW6K@1224,1RNMZ@1236,COG1477@1,COG1477@2	NA|NA|NA	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
C1_00958	198214.SF2297	1.3e-201	708.8	Gammaproteobacteria	ada	GO:0001130,GO:0003674,GO:0003700,GO:0003824,GO:0003908,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006355,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016740,GO:0016741,GO:0018125,GO:0018193,GO:0018198,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044728,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0046872,GO:0046914,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070988,GO:0071704,GO:0080090,GO:0080111,GO:0090304,GO:0140110,GO:1901360,GO:1901564,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141	2.1.1.63,3.2.2.21	ko:K00567,ko:K10778,ko:K13529,ko:K13530,ko:K15051	ko03410,map03410				ko00000,ko00001,ko01000,ko03000,ko03400				Bacteria	1N2YQ@1224,1RPR3@1236,COG0350@1,COG0350@2,COG2169@1,COG2169@2	NA|NA|NA	FL	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C1_00959	155864.EDL933_3378	5.1e-124	450.3	Escherichia	alkB	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008198,GO:0009451,GO:0009987,GO:0016070,GO:0016491,GO:0016705,GO:0016706,GO:0032451,GO:0033554,GO:0034641,GO:0035510,GO:0035511,GO:0035513,GO:0035515,GO:0035552,GO:0035553,GO:0042245,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043734,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0044728,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051213,GO:0051716,GO:0055114,GO:0070579,GO:0070988,GO:0070989,GO:0071704,GO:0080111,GO:0090304,GO:0140098,GO:1901360	1.14.11.33	ko:K03919					ko00000,ko01000,ko03400				Bacteria	1N5HB@1224,1S23P@1236,3XN90@561,COG3145@1,COG3145@2	NA|NA|NA	L	Dioxygenase that repairs alkylated DNA and RNA containing 3-methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing ethenoadenine, and no detectable activity towards 1-methylguanine or 3-methylthymine. Accepts double-stranded and single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron. Provides extensive resistance to alkylating agents such as MMS and DMS (SN2 agents), but not to MMNG and MNU (SN1 agents)
C1_00960	481805.EcolC_1439	9.4e-308	1062.0	Escherichia	yojI	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0006810,GO:0008144,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0016021,GO:0017076,GO:0030554,GO:0031224,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042884,GO:0042886,GO:0042891,GO:0043167,GO:0043168,GO:0044425,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K06159,ko:K06160	ko02010,map02010				ko00000,ko00001,ko02000	3.A.1.113.2,3.A.1.113.3			Bacteria	1MVIC@1224,1RMYK@1236,3XMBM@561,COG4615@1,COG4615@2	NA|NA|NA	P	ATP-binding
C1_00961	469008.B21_02096	1.7e-309	1067.8	Escherichia	mqo	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0008924,GO:0009898,GO:0016020,GO:0016491,GO:0016614,GO:0016615,GO:0016901,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071944,GO:0097159,GO:0098552,GO:0098562,GO:1901265,GO:1901363	1.1.5.4	ko:K00116	ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00009,M00011	R00360,R00361,R01257	RC00031	ko00000,ko00001,ko00002,ko01000			iE2348C_1286.E2348C_2355,iEC55989_1330.EC55989_2465,iJN746.PP_1251,iSB619.SA_RS12375	Bacteria	1MUCC@1224,1RRBV@1236,3XPAI@561,COG0579@1,COG0579@2	NA|NA|NA	C	malate dehydrogenase (menaquinone) activity
C1_00962	316407.1736850	8.4e-87	326.2	Escherichia	eco	GO:0003674,GO:0004857,GO:0004866,GO:0004867,GO:0005575,GO:0005623,GO:0006807,GO:0008150,GO:0008152,GO:0009892,GO:0010466,GO:0010605,GO:0010951,GO:0019222,GO:0019538,GO:0030162,GO:0030234,GO:0030288,GO:0030313,GO:0030414,GO:0031323,GO:0031324,GO:0031975,GO:0032268,GO:0032269,GO:0042597,GO:0043086,GO:0043170,GO:0044092,GO:0044238,GO:0044464,GO:0045861,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051336,GO:0051346,GO:0052547,GO:0052548,GO:0060255,GO:0061134,GO:0061135,GO:0065007,GO:0065009,GO:0071704,GO:0080090,GO:0098772,GO:1901564		ko:K08276					ko00000				Bacteria	1MZEN@1224,1S6Y9@1236,3XP1A@561,COG4574@1,COG4574@2	NA|NA|NA	M	General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases
C1_00964	481805.EcolC_1442	9e-97	359.4	Escherichia	napF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0044424,GO:0044464,GO:0050896		ko:K02572					ko00000				Bacteria	1N09Y@1224,1S4EB@1236,3XMR9@561,COG1145@1,COG1145@2,COG1149@1,COG1149@2	NA|NA|NA	C	ferredoxin-type protein NapF
C1_00965	155864.EDL933_3372	2.7e-39	167.5	Escherichia	napD	GO:0003674,GO:0005048,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0032879,GO:0032880,GO:0033218,GO:0042277,GO:0044424,GO:0044464,GO:0048519,GO:0050789,GO:0051049,GO:0051051,GO:0051223,GO:0051224,GO:0065007,GO:0070201,GO:0090087,GO:1904950		ko:K02570					ko00000				Bacteria	1N6UA@1224,1SCSX@1236,3XQ4H@561,COG3062@1,COG3062@2	NA|NA|NA	P	Plays a role in the correct assembly of subunits of the periplasmic NapAB enzyme
C1_00966	316407.85675313	0.0	1711.4	Escherichia	napA	GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005623,GO:0006091,GO:0008150,GO:0008152,GO:0008940,GO:0009061,GO:0009325,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016661,GO:0030151,GO:0030288,GO:0030313,GO:0031975,GO:0032991,GO:0042597,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0045333,GO:0046872,GO:0046914,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:1902494		ko:K02567	ko00910,ko01120,map00910,map01120	M00529,M00530	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000			iEC042_1314.EC042_2447,iECABU_c1320.ECABU_c25400,iECO103_1326.ECO103_2681,iECSE_1348.ECSE_2474,iECSF_1327.ECSF_2087,iECUMN_1333.ECUMN_2541,iEcHS_1320.EcHS_A2344,iEcolC_1368.EcolC_1444,iPC815.YPO3038,iSSON_1240.SSON_2264,ic_1306.c2745	Bacteria	1NS3T@1224,1RMWN@1236,3XNH6@561,COG0243@1,COG0243@2	NA|NA|NA	C	nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC
C1_00967	198214.SF2289	1.3e-130	472.2	Gammaproteobacteria	napG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02573					ko00000				Bacteria	1N9WY@1224,1RNHT@1236,COG0437@1,COG0437@2	NA|NA|NA	C	Ferredoxin-type protein
C1_00968	316407.85675311	4.2e-166	590.5	Escherichia	napH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02574					ko00000			iEcSMS35_1347.EcSMS35_2352	Bacteria	1MWR5@1224,1RQ1I@1236,3XNDP@561,COG0348@1,COG0348@2	NA|NA|NA	C	ferredoxin-type protein, NapH
C1_00969	1440052.EAKF1_ch3785	1.4e-83	315.5	Escherichia	napB	GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0044237,GO:0045333,GO:0055114		ko:K02568	ko00910,ko01120,map00910,map01120	M00529,M00530	R00798	RC02812	ko00000,ko00001,ko00002			iAF1260.b2203,iBWG_1329.BWG_1976,iE2348C_1286.E2348C_2347,iECDH10B_1368.ECDH10B_2360,iECDH1ME8569_1439.ECDH1ME8569_2138,iECED1_1282.ECED1_2668,iECH74115_1262.ECH74115_3340,iECIAI39_1322.ECIAI39_2341,iECNA114_1301.ECNA114_2295,iECOK1_1307.ECOK1_2437,iECP_1309.ECP_2244,iECS88_1305.ECS88_2350,iECSF_1327.ECSF_2084,iECSP_1301.ECSP_3082,iECUMN_1333.ECUMN_2538,iETEC_1333.ETEC_2337,iEcDH1_1363.EcDH1_1456,iEcolC_1368.EcolC_1447,iG2583_1286.G2583_2744,iJO1366.b2203,iLF82_1304.LF82_1453,iNRG857_1313.NRG857_11180,iSFV_1184.SFV_2279,iSF_1195.SF2287,iSFxv_1172.SFxv_2521,iS_1188.S2417,iUMN146_1321.UM146_05790,iY75_1357.Y75_RS11525	Bacteria	1RHGD@1224,1S84V@1236,3XQKT@561,COG3043@1,COG3043@2	NA|NA|NA	C	Electron transfer subunit of the periplasmic nitrate reductase complex NapAB
C1_00970	155864.EDL933_3367	3e-118	431.0	Escherichia	napC	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0044464,GO:0045333,GO:0055114,GO:0071944		ko:K02569,ko:K03532,ko:K07821	ko02020,map02020				ko00000,ko00001,ko02000	5.A.3.4		iEC042_1314.EC042_1072,iEcolC_1368.EcolC_1448	Bacteria	1MWV2@1224,1RQ9A@1236,3XNSB@561,COG3005@1,COG3005@2	NA|NA|NA	C	Mediates electron flow from quinones to the NapAB complex
C1_00971	316407.85675308	6.6e-113	413.3	Escherichia	ccmA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0009898,GO:0015232,GO:0015886,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019897,GO:0019898,GO:0022857,GO:0031224,GO:0031234,GO:0032991,GO:0042623,GO:0043190,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098533,GO:0098552,GO:0098562,GO:0098796,GO:0098797,GO:1901678,GO:1902494,GO:1902495,GO:1904949,GO:1990351	3.6.3.41	ko:K02193	ko02010,map02010	M00259			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107		iAPECO1_1312.APECO1_4358,iECED1_1282.ECED1_2666,iECS88_1305.ECS88_2348,iECUMN_1333.ECUMN_2536,iLF82_1304.LF82_0273,iNRG857_1313.NRG857_11170,iUMN146_1321.UM146_05800,iUTI89_1310.UTI89_C2479	Bacteria	1MZPC@1224,1S3R2@1236,3XPCV@561,COG4133@1,COG4133@2	NA|NA|NA	O	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system
C1_00972	155864.EDL933_3365	1.8e-92	345.5	Escherichia	ccmB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0031224,GO:0031226,GO:0032991,GO:0042623,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351	3.6.3.41	ko:K02193,ko:K02194	ko02010,map02010	M00259			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107		iECO111_1330.ECO111_2936	Bacteria	1NJB0@1224,1RRFJ@1236,3XMNW@561,COG2386@1,COG2386@2	NA|NA|NA	O	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1_00973	155864.EDL933_3364	3.2e-138	497.7	Escherichia	ccmC	GO:0001539,GO:0002048,GO:0002049,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006518,GO:0006629,GO:0006643,GO:0006664,GO:0006807,GO:0006810,GO:0006928,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009237,GO:0009247,GO:0009636,GO:0009987,GO:0015886,GO:0016020,GO:0016021,GO:0016209,GO:0016491,GO:0016684,GO:0019184,GO:0019290,GO:0019748,GO:0031224,GO:0031226,GO:0034641,GO:0040011,GO:0042221,GO:0043043,GO:0043107,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044425,GO:0044459,GO:0044464,GO:0044550,GO:0046467,GO:0048870,GO:0050896,GO:0051179,GO:0051181,GO:0051186,GO:0051188,GO:0051234,GO:0051674,GO:0051716,GO:0055114,GO:0070887,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0071973,GO:0071975,GO:0071977,GO:0071978,GO:0097237,GO:0097588,GO:0098754,GO:0098869,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1901678,GO:1903509,GO:1990748		ko:K02195	ko02010,map02010	M00259			ko00000,ko00001,ko00002,ko02000	3.A.1.107		iECDH1ME8569_1439.ECDH1ME8569_2134,iSFV_1184.SFV_2275,iSFxv_1172.SFxv_2517,iUTI89_1310.UTI89_C2477,ic_1306.c2736	Bacteria	1MU61@1224,1RP3R@1236,3XMMH@561,COG0755@1,COG0755@2	NA|NA|NA	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1_00974	155864.EDL933_3363	7.8e-26	122.5	Escherichia	ccmD	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0009898,GO:0015886,GO:0016020,GO:0031224,GO:0031226,GO:0031235,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0098552,GO:0098562,GO:1901678		ko:K02196	ko02010,map02010				ko00000,ko00001,ko02000	3.A.1.107		iB21_1397.B21_02084,iBWG_1329.BWG_1971,iE2348C_1286.E2348C_2342,iEC042_1314.EC042_2439,iEC55989_1330.EC55989_2451,iECABU_c1320.ECABU_c25320,iECBD_1354.ECBD_1462,iECB_1328.ECB_02125,iECDH10B_1368.ECDH10B_2355,iECDH1ME8569_1439.ECDH1ME8569_2133,iECD_1391.ECD_02125,iECED1_1282.ECED1_2663,iECH74115_1262.ECH74115_3335,iECIAI1_1343.ECIAI1_2280,iECIAI39_1322.ECIAI39_2336,iECNA114_1301.ECNA114_2290,iECO103_1326.ECO103_2673,iECO111_1330.ECO111_2934,iECO26_1355.ECO26_3124,iECOK1_1307.ECOK1_2432,iECP_1309.ECP_2238,iECS88_1305.ECS88_2345,iECSE_1348.ECSE_2466,iECSF_1327.ECSF_2079,iECSP_1301.ECSP_3077,iECUMN_1333.ECUMN_2533,iECs_1301.ECs3087,iEKO11_1354.EKO11_1558,iETEC_1333.ETEC_2332,iEcDH1_1363.EcDH1_1461,iEcE24377_1341.EcE24377A_2497,iEcHS_1320.EcHS_A2336,iEcSMS35_1347.EcSMS35_2346,iEcolC_1368.EcolC_1452,iJO1366.b2198,iLF82_1304.LF82_0276,iNRG857_1313.NRG857_11155,iSDY_1059.SDY_0880,iSFV_1184.SFV_2274,iSF_1195.SF2282,iSSON_1240.SSON_2256,iS_1188.S2412,iUMN146_1321.UM146_05815,iUMNK88_1353.UMNK88_2745,iUTI89_1310.UTI89_C2476,iY75_1357.Y75_RS11500,iZ_1308.Z3455,ic_1306.c2735	Bacteria	1NGBM@1224,1SGGH@1236,3XPYN@561,COG3114@1,COG3114@2	NA|NA|NA	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1_00975	155864.EDL933_3362	5e-84	317.0	Escherichia	ccmE	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006807,GO:0006810,GO:0008150,GO:0008152,GO:0009897,GO:0009986,GO:0009987,GO:0015886,GO:0016020,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0019538,GO:0020037,GO:0022607,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0051179,GO:0051181,GO:0051234,GO:0065003,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0097159,GO:0098552,GO:0098567,GO:1901363,GO:1901564,GO:1901678		ko:K02197					ko00000			iSSON_1240.SSON_2255	Bacteria	1RHN5@1224,1S5VA@1236,3XPHZ@561,COG2332@1,COG2332@2	NA|NA|NA	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C1_00976	316407.85675303	0.0	1263.1	Escherichia	ccmF	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0018193,GO:0018198,GO:0018378,GO:0019538,GO:0020037,GO:0022607,GO:0031224,GO:0031226,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564		ko:K02198,ko:K04016			R05712	RC00176	ko00000,ko02000	9.B.14.1			Bacteria	1MUQS@1224,1RMY5@1236,3XMDT@561,COG1138@1,COG1138@2	NA|NA|NA	O	Cytochrome c-type biogenesis protein
C1_00977	155864.EDL933_3360	1.9e-103	381.7	Escherichia	dsbE	GO:0003674,GO:0003756,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009897,GO:0009986,GO:0009987,GO:0015036,GO:0016020,GO:0016043,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0017004,GO:0022607,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0034622,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0055114,GO:0065003,GO:0071840,GO:0071944,GO:0098552,GO:0098567,GO:0140096		ko:K02199					ko00000,ko03110				Bacteria	1RI3N@1224,1S5YV@1236,3XN48@561,COG0526@1,COG0526@2	NA|NA|NA	O	Involved in disulfide bond formation. Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme
C1_00978	469008.B21_02080	3.2e-192	677.6	Escherichia	ccmH	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009897,GO:0009986,GO:0009987,GO:0015035,GO:0015036,GO:0016020,GO:0016043,GO:0016491,GO:0016667,GO:0017004,GO:0022607,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0034622,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0055114,GO:0065003,GO:0071840,GO:0071944,GO:0098552,GO:0098567		ko:K02198,ko:K02200,ko:K04017,ko:K04018					ko00000,ko02000	9.B.14.1			Bacteria	1MZZ5@1224,1S9DV@1236,3XP5K@561,COG3088@1,COG3088@2,COG4235@1,COG4235@2	NA|NA|NA	P	subunit of a heme lyase
C1_00979	469008.B21_02079	1.9e-110	405.2	Escherichia	narP	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141		ko:K07684,ko:K07685	ko02020,map02020	M00471,M00472			ko00000,ko00001,ko00002,ko02022				Bacteria	1Q7GF@1224,1RWWU@1236,3XM7A@561,COG2197@1,COG2197@2	NA|NA|NA	K	Nitrate nitrite response regulator
C1_00980	481805.EcolC_1458	0.0	1316.6	Escherichia	yejO												Bacteria	1R9A8@1224,1RS0C@1236,3XQGW@561,COG3468@1,COG3468@2	NA|NA|NA	MU	Pertactin
C1_00982	155864.EDL933_3356	0.0	1168.3	Escherichia	yejM	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K07014					ko00000				Bacteria	1MX6X@1224,1RPAU@1236,3XP9R@561,COG3083@1,COG3083@2	NA|NA|NA	S	sulfuric ester hydrolase activity
C1_00983	1440052.EAKF1_ch3798c	6.1e-32	142.9	Escherichia	yejL	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K09904					ko00000				Bacteria	1MZ9I@1224,1S8XQ@1236,3XQ2C@561,COG3082@1,COG3082@2	NA|NA|NA	S	Belongs to the UPF0352 family
C1_00984	155864.EDL933_3353	1.2e-183	649.0	Escherichia	ndpA	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003723,GO:0003727,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0009295,GO:0042802,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044424,GO:0044464,GO:0097159,GO:1901363		ko:K06899					ko00000,ko03036				Bacteria	1NXJU@1224,1RP8N@1236,3XP37@561,COG3081@1,COG3081@2	NA|NA|NA	S	nucleoid-associated protein
C1_00985	198214.SF2272	5.4e-46	189.9	Gammaproteobacteria	rplY	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016043,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113		ko:K02897	ko03010,map03010	M00178			ko00000,ko00001,ko00002,ko03011				Bacteria	1RDH0@1224,1S46A@1236,COG1825@1,COG1825@2	NA|NA|NA	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C1_00986	198214.SF2271	0.0	1198.3	Gammaproteobacteria	yejH	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042221,GO:0042493,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051301,GO:0051716,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360		ko:K19789					ko00000,ko03400				Bacteria	1MV9F@1224,1RNAN@1236,COG1061@1,COG1061@2	NA|NA|NA	L	Type III restriction protein res subunit
C1_00987	155864.EDL933_3350	7.2e-132	476.5	Escherichia	rsuA	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.19,5.4.99.20,5.4.99.22	ko:K06178,ko:K06181,ko:K06183					ko00000,ko01000,ko03009				Bacteria	1MU6M@1224,1RQA9@1236,3XNTC@561,COG1187@1,COG1187@2	NA|NA|NA	J	Responsible for synthesis of pseudouridine from uracil- 516 in 16S ribosomal RNA
C1_00988	316407.85675291	1.2e-214	752.3	Escherichia	bcr	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008150,GO:0015833,GO:0016020,GO:0022857,GO:0035442,GO:0035672,GO:0035673,GO:0042886,GO:0042887,GO:0042938,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071916,GO:0071944,GO:1904680		ko:K07552					ko00000,ko02000	2.A.1.2			Bacteria	1MW19@1224,1RMSZ@1236,3XM69@561,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
C1_00989	198214.SF2268	9.5e-61	239.2	Gammaproteobacteria	yejG												Bacteria	1RHRA@1224,1S625@1236,2ATGA@1,31IZZ@2	NA|NA|NA	S	YejG-like protein
C1_00990	316407.85675289	3.2e-292	1010.4	Escherichia	yejF	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008144,GO:0008150,GO:0015399,GO:0015405,GO:0015833,GO:0015893,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0035672,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042884,GO:0042886,GO:0042891,GO:0043167,GO:0043168,GO:0043492,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K13896	ko02010,map02010	M00349			ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24			Bacteria	1MU09@1224,1RMEI@1236,3XP6C@561,COG1123@1,COG4172@2	NA|NA|NA	P	Belongs to the ABC transporter superfamily
C1_00991	198214.SF2266	9.6e-197	692.6	Gammaproteobacteria	yejE	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0035672,GO:0042221,GO:0042493,GO:0042884,GO:0042886,GO:0042891,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944		ko:K02034,ko:K13895	ko02010,ko02024,map02010,map02024	M00239,M00349			ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.21,3.A.1.5.24			Bacteria	1MUM5@1224,1RNUH@1236,COG4239@1,COG4239@2	NA|NA|NA	P	ABC transporter (Permease
C1_00992	155864.EDL933_3345	1.3e-199	702.2	Escherichia	yejB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0022857,GO:0035672,GO:0042221,GO:0042493,GO:0042884,GO:0042886,GO:0042891,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944		ko:K02033,ko:K13894	ko02010,ko02024,map02010,map02024	M00239,M00349			ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.21,3.A.1.5.24			Bacteria	1MVKE@1224,1RMH8@1236,3XNSP@561,COG4174@1,COG4174@2	NA|NA|NA	P	ABC transporter permease
C1_00993	362663.ECP_2218	0.0	1235.3	Escherichia	yejA	GO:0005575,GO:0005623,GO:0006810,GO:0006857,GO:0008150,GO:0015833,GO:0015893,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042493,GO:0042597,GO:0042884,GO:0042886,GO:0042891,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071705		ko:K02035,ko:K13893	ko02010,ko02024,map02010,map02024	M00239,M00349			ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.21,3.A.1.5.24			Bacteria	1MUVU@1224,1RMA1@1236,3XMVP@561,COG4166@1,COG4166@2	NA|NA|NA	E	microcin transport
C1_00994	316407.1736841	1.4e-300	1038.1	Escherichia	rtn	GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016787,GO:0016788,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033554,GO:0042578,GO:0043565,GO:0044212,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071111,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141	3.1.4.52	ko:K13244,ko:K21090	ko02026,map02026		R08991	RC00296	ko00000,ko00001,ko01000				Bacteria	1NJQD@1224,1RNEP@1236,3XM4Z@561,COG2200@1,COG2200@2	NA|NA|NA	T	cyclic-guanylate-specific phosphodiesterase activity
C1_00995	155864.EDL933_3342	4.5e-100	370.5	Escherichia	spr	GO:0000270,GO:0003674,GO:0003824,GO:0004175,GO:0006022,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009254,GO:0016787,GO:0019538,GO:0030203,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901135,GO:1901564	3.4.17.13	ko:K13694,ko:K13695,ko:K19303					ko00000,ko01000,ko01002,ko01011				Bacteria	1N0EE@1224,1RR2X@1236,3XMFK@561,COG0791@1,COG0791@2	NA|NA|NA	M	A murein DD-endopeptidase with specificity for D-Ala- meso-diaminopimelic acid (mDAP) cross-links. Its role is probably to cleave D-Ala-mDAP cross-links to allow insertion of new glycans and thus cell wall expansion. Functionally redundant with MepM and MepH. Also has weak LD-carboxypeptidase activity on L-mDAP-D-Ala peptide bonds
C1_00996	155864.EDL933_3341	3.2e-127	461.1	Escherichia	lpxT	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016740,GO:0016772,GO:0016776,GO:0016787,GO:0016817,GO:0016818,GO:0022607,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044464,GO:0045229,GO:0050380,GO:0061024,GO:0071709,GO:0071840,GO:0071944	2.7.4.29	ko:K19803			R11186	RC00002	ko00000,ko01000,ko01005			iAPECO1_1312.APECO1_4380,iSBO_1134.SBO_2150	Bacteria	1MW7A@1224,1RPKF@1236,3XM6N@561,COG0671@1,COG0671@2	NA|NA|NA	I	Involved in the modification of the lipid A domain of lipopolysaccharides (LPS). Transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1- diphosphate. Contributes to the recycling of undecaprenyl phosphate (C55-P)
C1_00997	198214.SF2260	2.6e-188	664.5	Gammaproteobacteria	yeiR	GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0008270,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0043167,GO:0043169,GO:0046872,GO:0046914		ko:K07089					ko00000				Bacteria	1MVZV@1224,1RPKP@1236,COG0523@1,COG0523@2	NA|NA|NA	S	cobalamin synthesis protein, P47K
C1_00998	316407.85675285	9.4e-283	978.8	Escherichia	mtlK	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006063,GO:0006064,GO:0006082,GO:0008150,GO:0008152,GO:0008866,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019585,GO:0019586,GO:0019698,GO:0019752,GO:0032787,GO:0036094,GO:0042839,GO:0042840,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046395,GO:0046396,GO:0046397,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575	1.1.1.17,1.1.1.289,1.1.1.57,1.1.1.58,1.1.1.67,2.7.1.17	ko:K00009,ko:K00040,ko:K00041,ko:K00045,ko:K00854,ko:K19633	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014,M00061,M00631	R00868,R01639,R02454,R02555,R02703,R07346	RC00002,RC00085,RC00102,RC00538	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_2108,iECABU_c1320.ECABU_c17480,iECOK1_1307.ECOK1_4822,iUMN146_1321.UM146_22300,iUTI89_1310.UTI89_C5019	Bacteria	1MVZ7@1224,1RNIZ@1236,3XMJP@561,COG0246@1,COG0246@2	NA|NA|NA	G	Belongs to the mannitol dehydrogenase family
C1_00999	155864.EDL933_3338	2e-103	381.7	Escherichia	efp	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576		ko:K02356					ko00000,ko03012				Bacteria	1NWY9@1224,1RQ0N@1236,3XNJG@561,COG0231@1,COG0231@2	NA|NA|NA	J	translation elongation factor activity
C1_01000	316407.85675283	1.3e-43	181.8	Escherichia	yeiW			ko:K06940					ko00000				Bacteria	1MZCU@1224,1SCG7@1236,32S46@2,3XQ19@561,COG0727@1	NA|NA|NA	S	Putative zinc- or iron-chelating domain
C1_01001	155864.EDL933_3335	1.7e-213	748.4	Escherichia	setB	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0007059,GO:0008150,GO:0008643,GO:0009987,GO:0015766,GO:0015767,GO:0015772,GO:0016020,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071944		ko:K03291					ko00000,ko02000	2.A.1.20		iEC042_1314.EC042_2403	Bacteria	1MWWU@1224,1RN2I@1236,3XMT3@561,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
C1_01002	155864.EDL933_3333	4.5e-200	703.7	Escherichia	fruB	GO:0003674,GO:0003824,GO:0005215,GO:0005353,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0008645,GO:0008982,GO:0009401,GO:0015144,GO:0015145,GO:0015149,GO:0015749,GO:0015755,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0019897,GO:0019898,GO:0022804,GO:0022857,GO:0022877,GO:0032445,GO:0034219,GO:0044425,GO:0044459,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563	2.7.1.121,2.7.1.202,2.7.3.9	ko:K02768,ko:K02784,ko:K05881,ko:K08483,ko:K08485,ko:K11183,ko:K11189,ko:K11201	ko00051,ko00561,ko01100,ko01120,ko02060,map00051,map00561,map01100,map01120,map02060	M00273,M00306	R01012,R03232	RC00015,RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1,8.A.7,8.A.8.1.1		e_coli_core.b2415,iAF1260.b2415,iB21_1397.B21_02276,iBWG_1329.BWG_2177,iE2348C_1286.E2348C_2601,iEC042_1314.EC042_2624,iEC55989_1330.EC55989_2705,iECABU_c1320.ECABU_c27360,iECBD_1354.ECBD_1266,iECB_1328.ECB_02315,iECDH10B_1368.ECDH10B_2580,iECDH1ME8569_1439.ECDH1ME8569_2349,iECDH1ME8569_1439.EcDH1_1246,iECD_1391.ECD_02315,iECED1_1282.ECED1_2859,iECH74115_1262.ECH74115_3646,iECIAI1_1343.ECIAI1_2473,iECIAI39_1322.ECIAI39_2561,iECNA114_1301.ECNA114_2492,iECO103_1326.ECO103_2934,iECO111_1330.ECO111_3145,iECO26_1355.ECO26_3468,iECOK1_1307.ECOK1_2732,iECP_1309.ECP_2439,iECS88_1305.ECS88_2605,iECSE_1348.ECSE_2706,iECSF_1327.ECSF_2279,iECSP_1301.ECSP_3363,iECUMN_1333.ECUMN_2737,iECW_1372.ECW_m2644,iECs_1301.ECs1703,iECs_1301.ECs3287,iEKO11_1354.EKO11_1313,iETEC_1333.ETEC_2528,iEcDH1_1363.EcDH1_1246,iEcE24377_1341.EcE24377A_2702,iEcHS_1320.EcHS_A2550,iEcSMS35_1347.EcSMS35_2570,iEcolC_1368.EcolC_1263,iG2583_1286.G2583_2947,iJO1366.b2415,iJR904.b2415,iLF82_1304.LF82_1769,iNRG857_1313.NRG857_12110,iSBO_1134.SBO_2155,iSBO_1134.SBO_2439,iSDY_1059.SDY_2612,iSFV_1184.SFV_2467,iSF_1195.SF2470,iSFxv_1172.SFxv_2719,iSSON_1240.SSON_2504,iS_1188.S2616,iSbBS512_1146.SbBS512_E0794,iSbBS512_1146.SbBS512_E2765,iUMN146_1321.UM146_04545,iUMNK88_1353.UMNK88_3017,iUTI89_1310.UTI89_C2749,iWFL_1372.ECW_m2644,iY75_1357.Y75_RS12655,iZ_1308.Z1969,iZ_1308.Z3681,ic_1306.c2950	Bacteria	1MVP6@1224,1RQP4@1236,3XMPF@561,COG1925@1,COG1925@2,COG4668@1,COG4668@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FruAB PTS system is involved in fructose transport
C1_01003	155864.EDL933_3332	4.9e-176	623.6	Escherichia	fruK	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006000,GO:0006001,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008443,GO:0008662,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019318,GO:0019320,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046835,GO:0071704,GO:1901575	2.7.1.11,2.7.1.56	ko:K00882,ko:K16370	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00345	R00756,R02071,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000			iAF1260.b2168,iAPECO1_1312.APECO1_4386,iAPECO1_1312.APECO1_793,iB21_1397.B21_02056,iEC042_1314.EC042_2401,iEC55989_1330.EC55989_2421,iECABU_c1320.ECABU_c24990,iECBD_1354.ECBD_1490,iECB_1328.ECB_02097,iECDH10B_1368.ECDH10B_2325,iECDH1ME8569_1439.ECDH1ME8569_2104,iECD_1391.ECD_02097,iECED1_1282.ECED1_2616,iECH74115_1262.ECH74115_3304,iECIAI1_1343.ECIAI1_2248,iECIAI39_1322.ECIAI39_2308,iECNA114_1301.ECNA114_2259,iECO103_1326.ECO103_2643,iECO111_1330.ECO111_2886,iECO26_1355.ECO26_3080,iECOK1_1307.ECOK1_2400,iECP_1309.ECP_2208,iECS88_1305.ECS88_2316,iECSE_1348.ECSE_2436,iECSF_1327.ECSF_2049,iECSP_1301.ECSP_3046,iECUMN_1333.ECUMN_2504,iECW_1372.ECW_m2369,iECs_1301.ECs3060,iEKO11_1354.EKO11_1586,iETEC_1333.ETEC_2303,iEcDH1_1363.EcDH1_1490,iEcHS_1320.EcHS_A2305,iEcSMS35_1347.EcSMS35_2315,iEcolC_1368.EcolC_1480,iG2583_1286.G2583_2711,iJO1366.b2168,iJR904.b2168,iLF82_1304.LF82_0744,iNRG857_1313.NRG857_11005,iPC815.YPO1299,iSBO_1134.SBO_2156,iSDY_1059.SDY_2316,iSFV_1184.SFV_2243,iSF_1195.SF2253,iSFxv_1172.SFxv_2486,iS_1188.S2382,iUMN146_1321.UM146_05955,iUMNK88_1353.UMNK88_2713,iUTI89_1310.UTI89_C1916,iUTI89_1310.UTI89_C2443,iWFL_1372.ECW_m2369,iY75_1357.Y75_RS11345,iZ_1308.Z3426,ic_1306.c2703	Bacteria	1MVNW@1224,1RP6K@1236,3XMTQ@561,COG1105@1,COG1105@2	NA|NA|NA	F	Belongs to the carbohydrate kinase PfkB family
C1_01004	469008.B21_02055	1.3e-283	981.9	Escherichia	fruA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090582	2.7.1.202	ko:K02768,ko:K02769,ko:K02770,ko:K11202	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273,M00306	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1		iEcSMS35_1347.EcSMS35_2314,iJN746.PP_0795,iSbBS512_1146.SbBS512_E0796	Bacteria	1MXFN@1224,1RMZC@1236,3XN1D@561,COG1299@1,COG1299@2,COG1445@1,COG1445@2,COG3925@1,COG3925@2	NA|NA|NA	G	Pts system fructose-specific
C1_01005	469008.B21_02054	1.3e-176	625.5	Escherichia	psuK	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050225	2.7.1.15,2.7.1.45,2.7.1.83	ko:K00852,ko:K00874,ko:K16328	ko00030,ko00240,ko01100,ko01120,ko01200,map00030,map00240,map01100,map01120,map01200	M00061,M00308,M00631	R01051,R01541,R02750,R03315	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000				Bacteria	1MXSY@1224,1RQKG@1236,3XQEA@561,COG0524@1,COG0524@2	NA|NA|NA	G	pseudouridine kinase activity
C1_01006	362663.ECP_2205	2.3e-165	588.2	Escherichia	psuG	GO:0001522,GO:0003674,GO:0003824,GO:0004730,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006139,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0016043,GO:0016070,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016787,GO:0016798,GO:0016829,GO:0016835,GO:0016836,GO:0019200,GO:0022607,GO:0030145,GO:0034641,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046835,GO:0046872,GO:0046914,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0090304,GO:1901360	4.2.1.70	ko:K16329	ko00240,map00240		R01055	RC00432,RC00433	ko00000,ko00001,ko01000				Bacteria	1MUQU@1224,1RQJH@1236,3XQK2@561,COG2313@1,COG2313@2	NA|NA|NA	Q	Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway
C1_01007	199310.c2698	4.8e-211	740.3	Escherichia	yeiM	GO:0003674,GO:0005215,GO:0005337,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0015858,GO:0015931,GO:0015932,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:1901264,GO:1901505,GO:1901642		ko:K03317,ko:K16324					ko00000,ko02000	2.A.41,2.A.41.2.9			Bacteria	1MXXX@1224,1RMBX@1236,3XQ7K@561,COG1972@1,COG1972@2	NA|NA|NA	F	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C1_01008	155864.EDL933_3327	1.1e-127	462.6	Escherichia	yeiL	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576		ko:K16326					ko00000,ko03000				Bacteria	1R53A@1224,1RYMX@1236,3XQKG@561,COG0664@1,COG0664@2	NA|NA|NA	K	Cyclic nucleotide-monophosphate binding domain
C1_01009	481805.EcolC_1486	4.6e-182	643.7	Escherichia	rihB	GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006152,GO:0006213,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008477,GO:0009056,GO:0009116,GO:0009119,GO:0009164,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019439,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042454,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0045437,GO:0046131,GO:0046133,GO:0046135,GO:0046483,GO:0046700,GO:0046872,GO:0050263,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658	3.2.2.1,3.2.2.8	ko:K01239,ko:K01250,ko:K10213	ko00230,ko00240,ko00760,ko01100,map00230,map00240,map00760,map01100		R01245,R01273,R01677,R01770,R02137,R02143	RC00033,RC00063,RC00122,RC00318,RC00485	ko00000,ko00001,ko01000			iECH74115_1262.ECH74115_3298,iECSP_1301.ECSP_3040,iECs_1301.ECs3054,iSFV_1184.SFV_2237,iSF_1195.SF2247,iSFxv_1172.SFxv_2480,iS_1188.S2376,iSbBS512_1146.SbBS512_E0598,iZ_1308.Z3419	Bacteria	1MUIW@1224,1RQ1V@1236,3XQBU@561,COG1957@1,COG1957@2	NA|NA|NA	F	Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively. Has a clear preference for cytidine over uridine. Strictly specific for ribonucleosides
C1_01010	316407.85675275	1.9e-207	728.4	Escherichia	nupX	GO:0003674,GO:0005215,GO:0005337,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0015858,GO:0015931,GO:0015932,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:1901264,GO:1901505,GO:1901642		ko:K03317,ko:K16324,ko:K16325					ko00000,ko02000	2.A.41,2.A.41.2.10,2.A.41.2.9			Bacteria	1MXXX@1224,1RMBX@1236,3XQ7K@561,COG1972@1,COG1972@2	NA|NA|NA	F	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C1_01011	469008.B21_02048	2.4e-203	714.5	Escherichia	yeiI		2.7.1.15,2.7.1.45,2.7.1.83	ko:K00852,ko:K00874,ko:K16328	ko00030,ko00240,ko01100,ko01120,ko01200,map00030,map00240,map01100,map01120,map01200	M00061,M00308,M00631	R01051,R01541,R02750,R03315	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000				Bacteria	1MXSY@1224,1RQKG@1236,3XQ9B@561,COG0524@1,COG0524@2,COG1522@1,COG1522@2	NA|NA|NA	G	phosphotransferase activity, alcohol group as acceptor
C1_01012	481805.EcolC_1489	2.2e-162	578.2	Escherichia	nfo	GO:0000726,GO:0003674,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0008833,GO:0009987,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	3.1.21.2	ko:K01151	ko03410,map03410				ko00000,ko00001,ko01000,ko03400				Bacteria	1MX4Y@1224,1RQ60@1236,3XNSH@561,COG0648@1,COG0648@2	NA|NA|NA	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C1_01013	155864.EDL933_3322	7.1e-184	649.8	Escherichia	yeiH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1MVIP@1224,1RPSG@1236,3XNYN@561,COG2855@1,COG2855@2	NA|NA|NA	S	Conserved hypothetical protein 698
C1_01014	199310.c2692	1.7e-162	578.6	Escherichia	yeiE	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576											Bacteria	1MWVU@1224,1RPT8@1236,3XNEX@561,COG0583@1,COG0583@2	NA|NA|NA	K	DNA-binding transcription factor activity
C1_01015	316407.85675270	1.7e-279	968.0	Escherichia	lysP	GO:0000096,GO:0000097,GO:0000100,GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008152,GO:0008509,GO:0008514,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0015075,GO:0015171,GO:0015318,GO:0015711,GO:0015806,GO:0015849,GO:0016020,GO:0016021,GO:0016043,GO:0016053,GO:0019752,GO:0022607,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042802,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044425,GO:0044459,GO:0044464,GO:0046394,GO:0046942,GO:0046943,GO:0046982,GO:0046983,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0072337,GO:0072348,GO:0072349,GO:0098656,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901682,GO:1903825,GO:1905039		ko:K03293,ko:K11733,ko:K16235					ko00000,ko02000	2.A.3.1,2.A.3.1.10,2.A.3.1.2		iSBO_1134.SBO_2171,iYL1228.KPN_02594	Bacteria	1QTSM@1224,1RNI2@1236,3XP8G@561,COG0833@1,COG0833@2	NA|NA|NA	E	Lysine-specific permease
C1_01016	316407.85675269	0.0	1362.1	Escherichia	cirA	GO:0000041,GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006826,GO:0006855,GO:0006873,GO:0006875,GO:0006879,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009279,GO:0009987,GO:0015031,GO:0015238,GO:0015267,GO:0015343,GO:0015399,GO:0015405,GO:0015450,GO:0015620,GO:0015682,GO:0015685,GO:0015688,GO:0015711,GO:0015833,GO:0015850,GO:0015891,GO:0015893,GO:0016020,GO:0016021,GO:0019725,GO:0019867,GO:0019904,GO:0022803,GO:0022804,GO:0022834,GO:0022836,GO:0022857,GO:0022884,GO:0022885,GO:0030001,GO:0030003,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031975,GO:0033036,GO:0033212,GO:0033214,GO:0042221,GO:0042493,GO:0042592,GO:0042886,GO:0042887,GO:0042891,GO:0042895,GO:0042912,GO:0042914,GO:0042930,GO:0043213,GO:0044425,GO:0044462,GO:0044464,GO:0044718,GO:0045184,GO:0045203,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0072512,GO:0098771,GO:1901678,GO:1904680		ko:K16089,ko:K19611	ko02020,map02020				ko00000,ko00001,ko02000	1.B.14.1,1.B.14.1.22,1.B.14.1.3,1.B.14.1.5,1.B.14.10		iECO103_1326.ECO103_2630,iSDY_1059.SDY_0512	Bacteria	1MUC1@1224,1RNHR@1236,3XM4N@561,COG1629@1,COG4771@2	NA|NA|NA	P	Colicin I receptor
C1_01017	199310.c2689	2.9e-164	584.3	Escherichia	yeiG	GO:0003674,GO:0003824,GO:0004416,GO:0005488,GO:0005515,GO:0006081,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010033,GO:0016043,GO:0016787,GO:0016788,GO:0016790,GO:0016999,GO:0017001,GO:0017144,GO:0018738,GO:0022607,GO:0042221,GO:0042802,GO:0043933,GO:0044085,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046185,GO:0046292,GO:0046294,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051716,GO:0065003,GO:0070887,GO:0071704,GO:0071840,GO:0097237,GO:0098754,GO:0110095,GO:0110096,GO:1901575,GO:1901700,GO:1901701,GO:1990748	3.1.2.12	ko:K01070,ko:K09795	ko00680,ko01120,ko01200,map00680,map01120,map01200		R00527	RC00167,RC00320	ko00000,ko00001,ko01000		CE1	iE2348C_1286.E2348C_2300	Bacteria	1MUID@1224,1RMR3@1236,3XP8I@561,COG0627@1,COG0627@2	NA|NA|NA	S	Serine hydrolase involved in the detoxification of formaldehyde
C1_01018	155864.EDL933_3316	5.1e-119	433.7	Escherichia	folE	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006082,GO:0006139,GO:0006575,GO:0006725,GO:0006729,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008616,GO:0009058,GO:0009108,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0019752,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0042455,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901657,GO:1901659	2.7.6.3,3.5.4.16	ko:K00950,ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R03503,R04639,R05046,R05048	RC00002,RC00017,RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000			iNJ661.Rv3609c	Bacteria	1MY3N@1224,1RMQM@1236,3XMJH@561,COG0302@1,COG0302@2	NA|NA|NA	F	GTP cyclohydrolase
C1_01019	469008.B21_02040	4.1e-217	760.4	Escherichia	yeiB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K07148					ko00000				Bacteria	1MWHW@1224,1RQ08@1236,3XMAP@561,COG2311@1,COG2311@2	NA|NA|NA	S	Protein of unknown function (DUF418)
C1_01020	198214.SF2236	1.1e-189	669.1	Gammaproteobacteria	galS	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141		ko:K02529,ko:K03487					ko00000,ko03000				Bacteria	1MU1G@1224,1RMSP@1236,COG1609@1,COG1609@2	NA|NA|NA	K	transcriptional regulator
C1_01021	198214.SF2235	1e-184	652.5	Gammaproteobacteria	mglB	GO:0005575,GO:0005623,GO:0006810,GO:0006935,GO:0008150,GO:0008643,GO:0008645,GO:0009605,GO:0015749,GO:0015757,GO:0015765,GO:0030288,GO:0030313,GO:0031975,GO:0034219,GO:0040011,GO:0042221,GO:0042330,GO:0042597,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:1901264,GO:1901656		ko:K10439,ko:K10540	ko02010,ko02030,map02010,map02030	M00212,M00214			ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.3		iPC815.YPO1507	Bacteria	1MWGU@1224,1RPE9@1236,COG1879@1,COG1879@2	NA|NA|NA	G	Wtih MglAC is involved in the transport of beta-methylgalactoside
C1_01022	198214.SF2234	3.2e-286	990.3	Gammaproteobacteria	mglA	GO:0000166,GO:0003674,GO:0005215,GO:0005354,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008643,GO:0008645,GO:0009987,GO:0015144,GO:0015145,GO:0015149,GO:0015592,GO:0015749,GO:0015757,GO:0015765,GO:0016020,GO:0017076,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034219,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0050896,GO:0051119,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071702,GO:0071944,GO:0097159,GO:0097367,GO:1901264,GO:1901265,GO:1901363,GO:1901505,GO:1901656	3.6.3.17	ko:K10542	ko02010,map02010	M00214			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.3		iECH74115_1262.ECH74115_3282,iECSP_1301.ECSP_3027	Bacteria	1MU22@1224,1RMCH@1236,COG1129@1,COG1129@2	NA|NA|NA	P	import. Responsible for energy coupling to the transport system
C1_01023	316407.85675262	5.8e-175	620.2	Escherichia	mglC	GO:0003674,GO:0005215,GO:0005354,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006950,GO:0006974,GO:0008150,GO:0008643,GO:0008645,GO:0009987,GO:0015144,GO:0015145,GO:0015149,GO:0015592,GO:0015749,GO:0015757,GO:0015765,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0033554,GO:0034219,GO:0044425,GO:0044464,GO:0050896,GO:0051119,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071702,GO:0071944,GO:1901264,GO:1901505,GO:1901656		ko:K10541	ko02010,map02010	M00214			ko00000,ko00001,ko00002,ko02000	3.A.1.2.3		iECABU_c1320.ECABU_c24780,iECNA114_1301.ECNA114_2239,iECP_1309.ECP_2187,iECSF_1327.ECSF_2030,iLF82_1304.LF82_1340,iNRG857_1313.NRG857_10910,ic_1306.c2682	Bacteria	1N621@1224,1RP8Q@1236,3XNHK@561,COG4211@1,COG4211@2	NA|NA|NA	G	the binding-protein-dependent transport system
C1_01024	155864.EDL933_3308	5.9e-238	829.7	Escherichia	preA	GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0006139,GO:0006206,GO:0006208,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016491,GO:0016651,GO:0034641,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0046113,GO:0046483,GO:0046700,GO:0048037,GO:0051536,GO:0051540,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	1.3.1.1	ko:K02572,ko:K02573,ko:K17723	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	M00046	R00977,R01414,R11026	RC00072,RC00123	ko00000,ko00001,ko00002,ko01000			iE2348C_1286.E2348C_2293	Bacteria	1MXER@1224,1RRTA@1236,3XNY7@561,COG0167@1,COG0167@2,COG1146@1,COG1146@2	NA|NA|NA	CF	Involved in pyrimidine base degradation. Catalyzes physiologically the reduction of uracil to 5,6-dihydrouracil (DHU) by using NADH as a specific cosubstrate. It also catalyzes the reverse reaction and the reduction of thymine to 5,6- dihydrothymine (DHT)
C1_01025	316407.85675260	1.2e-230	805.4	Escherichia	preT	GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006208,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016491,GO:0016651,GO:0034641,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0048037,GO:0051536,GO:0051540,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	1.3.1.1	ko:K17722	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	M00046	R00977,R01414,R11026	RC00072,RC00123	ko00000,ko00001,ko00002,ko01000			iECED1_1282.ECED1_2593,iECO103_1326.ECO103_2621,iLF82_1304.LF82_3021	Bacteria	1MU2H@1224,1RS6R@1236,3XMQ4@561,COG0493@1,COG0493@2	NA|NA|NA	C	Involved in pyrimidine base degradation. Catalyzes physiologically the reduction of uracil to 5,6-dihydrouracil (DHU) by using NADH as a specific cosubstrate. It also catalyzes the reverse reaction and the reduction of thymine to 5,6- dihydrothymine (DHT)
C1_01026	155864.EDL933_3306	1.7e-37	161.4	Escherichia	yeiS												Bacteria	1NA12@1224,1SFRD@1236,2EAMC@1,334PZ@2,3XQ2A@561	NA|NA|NA	S	Protein of unknown function (DUF2542)
C1_01027	155864.EDL933_3305	2.6e-129	468.0	Escherichia	sanA	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0042221,GO:0042493,GO:0044425,GO:0044464,GO:0050896,GO:0071944		ko:K03748					ko00000				Bacteria	1MURW@1224,1RMG7@1236,3XPEI@561,COG2949@1,COG2949@2	NA|NA|NA	S	Participates in the barrier function of the cell envelope
C1_01028	198214.SF2228	2.1e-165	588.2	Gammaproteobacteria	cdd	GO:0001882,GO:0001884,GO:0003674,GO:0003824,GO:0004126,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006216,GO:0006217,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008655,GO:0009056,GO:0009058,GO:0009116,GO:0009119,GO:0009120,GO:0009164,GO:0009972,GO:0009987,GO:0015949,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0036094,GO:0042454,GO:0042802,GO:0043094,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046087,GO:0046092,GO:0046121,GO:0046125,GO:0046127,GO:0046131,GO:0046133,GO:0046135,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0047844,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0097159,GO:0097367,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100		R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000			iECO103_1326.ECO103_2618	Bacteria	1MY2R@1224,1RMRX@1236,COG0295@1,COG0295@2	NA|NA|NA	F	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
C1_01029	198214.SF2227	1.9e-116	425.2	Gammaproteobacteria	yohK	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1MV81@1224,1RS5C@1236,COG1346@1,COG1346@2	NA|NA|NA	M	effector of murein hydrolase
C1_01030	198214.SF2226	1.8e-63	248.4	Gammaproteobacteria	lrgA	GO:0000270,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0006810,GO:0008104,GO:0008150,GO:0008152,GO:0008565,GO:0009056,GO:0009057,GO:0009253,GO:0015031,GO:0015833,GO:0016020,GO:0030203,GO:0033036,GO:0042886,GO:0043170,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575		ko:K05338,ko:K06518	ko02020,map02020				ko00000,ko00001,ko02000	1.E.14.1,1.E.14.2			Bacteria	1NAY3@1224,1SD5V@1236,COG1380@1,COG1380@2	NA|NA|NA	S	UPF0299 membrane protein
C1_01031	199310.c2672	5.7e-180	636.7	Escherichia	dusC	GO:0000049,GO:0000166,GO:0002943,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010181,GO:0010467,GO:0016070,GO:0016491,GO:0016627,GO:0017150,GO:0032553,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0048037,GO:0050662,GO:0055114,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363		ko:K05541					ko00000,ko01000,ko03016				Bacteria	1MUSM@1224,1RMMM@1236,3XNQI@561,COG0042@1,COG0042@2	NA|NA|NA	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C1_01032	199310.c2671	8.3e-282	975.7	Escherichia	mdtQ	GO:0008150,GO:0042221,GO:0046677,GO:0050896		ko:K15550					ko00000,ko02000	1.B.17.3.9			Bacteria	1MUZZ@1224,1RQEP@1236,3XMP8@561,COG1538@1,COG1538@2	NA|NA|NA	MU	Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride
C1_01033	481805.EcolC_1510	6.6e-139	500.0	Escherichia													Bacteria	1Q7EW@1224,1RPFV@1236,3XMUI@561,COG1028@1,COG1028@2	NA|NA|NA	IQ	oxidoreductase activity
C1_01034	316407.85675250	5.1e-107	393.7	Escherichia	yohD	GO:0000003,GO:0000910,GO:0005575,GO:0005623,GO:0005886,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0032505,GO:0043093,GO:0044464,GO:0051301,GO:0071944											Bacteria	1R5SJ@1224,1S274@1236,3XMGA@561,COG0586@1,COG0586@2	NA|NA|NA	S	reproductive process
C1_01035	155864.EDL933_3290	2.8e-105	387.9	Escherichia	yohC	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0033554,GO:0044464,GO:0050896,GO:0051716,GO:0071944											Bacteria	1MW9T@1224,1RQV1@1236,28H8Z@1,2Z7KS@2,3XP9F@561	NA|NA|NA	S	cellular response to DNA damage stimulus
C1_01036	1440052.EAKF1_ch3865	8.6e-165	586.3	Escherichia	pbpG	GO:0000003,GO:0000270,GO:0000910,GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0006022,GO:0006508,GO:0006807,GO:0007049,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016043,GO:0016787,GO:0019538,GO:0019954,GO:0022402,GO:0022414,GO:0030203,GO:0032505,GO:0042221,GO:0042493,GO:0042597,GO:0043093,GO:0043170,GO:0044238,GO:0044464,GO:0045229,GO:0050896,GO:0051301,GO:0070011,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0140096,GO:1901135,GO:1901564	3.4.16.4	ko:K07258,ko:K07262	ko00550,ko01100,map00550,map01100				ko00000,ko00001,ko01000,ko01002,ko01011			iECO103_1326.ECO103_2610,iYL1228.KPN_02573	Bacteria	1MWZA@1224,1RQBF@1236,3XMMC@561,COG1686@1,COG1686@2	NA|NA|NA	M	Belongs to the peptidase S11 family
C1_01037	199310.c2664	0.0	1164.1	Escherichia	dld	GO:0000166,GO:0003674,GO:0003824,GO:0004457,GO:0004458,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006089,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009898,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016614,GO:0016898,GO:0016901,GO:0019516,GO:0019752,GO:0019897,GO:0019898,GO:0022900,GO:0022904,GO:0031234,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0048037,GO:0050660,GO:0050662,GO:0051990,GO:0055114,GO:0071704,GO:0071944,GO:0071949,GO:0097159,GO:0098552,GO:0098562,GO:1901265,GO:1901363,GO:1901615	1.1.5.12	ko:K03777	ko00620,ko01120,map00620,map01120		R00704,R11591	RC00044	ko00000,ko00001,ko01000			iEcHS_1320.EcHS_A2268,iPC815.YPO1177	Bacteria	1MVG7@1224,1RN5V@1236,3XNSW@561,COG0277@1,COG0277@2	NA|NA|NA	C	Catalyzes the oxidation of D-lactate to pyruvate
C1_01038	469008.B21_02020	0.0	1489.2	Escherichia	bglX	GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0008422,GO:0009056,GO:0009057,GO:0009251,GO:0015926,GO:0016020,GO:0016052,GO:0016787,GO:0016798,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044042,GO:0044238,GO:0044464,GO:0071704,GO:0071944,GO:1901575	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110		R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000		GH3	iECOK1_1307.ECOK1_2363,iECS88_1305.ECS88_2276,iSF_1195.SF2217,iSFxv_1172.SFxv_2448,iS_1188.S2346,iUMN146_1321.UM146_06125,iUTI89_1310.UTI89_C2406	Bacteria	1MVIV@1224,1RMA0@1236,3XN99@561,COG1472@1,COG1472@2	NA|NA|NA	G	Belongs to the glycosyl hydrolase 3 family
C1_01039	316407.85675245	7.2e-164	583.2	Escherichia	yehZ	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0009628,GO:0009987,GO:0015695,GO:0015696,GO:0015697,GO:0015838,GO:0016020,GO:0031460,GO:0033554,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0071214,GO:0071470,GO:0071474,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0104004		ko:K05845	ko02010,map02010	M00209			ko00000,ko00001,ko00002,ko02000	3.A.1.12		iE2348C_1286.E2348C_2278,iEC55989_1330.EC55989_2381,iECIAI39_1322.ECIAI39_0865,iECO103_1326.ECO103_2607,iECSE_1348.ECSE_2399	Bacteria	1MV9N@1224,1RN72@1236,3XM88@561,COG1732@1,COG1732@2	NA|NA|NA	M	Part of an ABC transporter complex involved in low- affinity glycine betaine uptake. Binds glycine betaine with low affinity
C1_01040	469008.B21_02018	8.4e-202	709.5	Escherichia	yehY	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015697,GO:0015838,GO:0016020,GO:0031460,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0072337		ko:K05846	ko02010,map02010	M00209			ko00000,ko00001,ko00002,ko02000	3.A.1.12		iECNA114_1301.ECNA114_2219,iECSF_1327.ECSF_2012,iETEC_1333.ETEC_2266	Bacteria	1MXA1@1224,1RQDV@1236,3XN5U@561,COG1174@1,COG1174@2	NA|NA|NA	P	Permease protein
C1_01041	198214.SF2214	3.7e-168	597.4	Gammaproteobacteria	yehX	GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015697,GO:0015838,GO:0031460,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0072337		ko:K05847	ko02010,map02010	M00209			ko00000,ko00001,ko00002,ko02000	3.A.1.12		iECED1_1282.ECED1_2573,iEcE24377_1341.EcE24377A_2418,iPC815.YPO1198	Bacteria	1QTUC@1224,1RQWQ@1236,COG1125@1,COG1125@2	NA|NA|NA	E	abc transporter atp-binding protein
C1_01042	155864.EDL933_3281	7.8e-121	439.9	Escherichia	yehW	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015697,GO:0015838,GO:0016020,GO:0031460,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0072337		ko:K05846	ko02010,map02010	M00209			ko00000,ko00001,ko00002,ko02000	3.A.1.12		iEC042_1314.EC042_2361,iECUMN_1333.ECUMN_2462	Bacteria	1MX8D@1224,1RSDR@1236,3XMU1@561,COG1174@1,COG1174@2	NA|NA|NA	P	Permease protein
C1_01043	316407.85675241	9.8e-09	64.7	Escherichia	yohO												Bacteria	1QNAB@1224,1TKTR@1236,2BT6J@1,32NBR@2,3XRE6@561	NA|NA|NA		
C1_01044	316407.85675240	2.9e-139	501.1	Escherichia	mlrA	GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K21089,ko:K21972,ko:K22491	ko02026,map02026				ko00000,ko00001,ko03000				Bacteria	1R9SN@1224,1S967@1236,3XNCJ@561,COG0789@1,COG0789@2	NA|NA|NA	K	transcriptional regulator
C1_01045	198214.SF2198	0.0	1078.5	Gammaproteobacteria	yehU	GO:0000160,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016310,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023052,GO:0031224,GO:0031226,GO:0035556,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0071944,GO:1901564	2.7.13.3	ko:K02478,ko:K07704	ko02020,map02020	M00492			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022			iECW_1372.ECW_m2327,iWFL_1372.ECW_m2327	Bacteria	1QUB1@1224,1T1RX@1236,COG3275@1,COG3275@2	NA|NA|NA	T	Histidine kinase
C1_01046	155864.EDL933_3202	5.3e-130	470.3	Escherichia	yehT	GO:0000160,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0023052,GO:0031323,GO:0031326,GO:0035556,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141		ko:K02477					ko00000,ko02022				Bacteria	1MUE8@1224,1RMJJ@1236,3XMQB@561,COG3279@1,COG3279@2	NA|NA|NA	K	Member of the two-component regulatory system BtsS BtsR, which is part of a nutrient-sensing regulatory network composed of BtsS BtsR, the low-affinity pyruvate signaling system YpdA YpdB and their respective target proteins, YjiY and YhjX. Responds to depletion of nutrients, specifically serine, and the concomitant presence of extracellular pyruvate. BtsR regulates expression of yjiY by binding to its promoter region. Activation of the BtsS BtsR signaling cascade also suppresses YpdA YpdB-mediated yhjX induction
C1_01047	316407.85675237	3.3e-80	304.3	Escherichia	yehS												Bacteria	1RD33@1224,1S3ZU@1236,3XPFU@561,COG4807@1,COG4807@2	NA|NA|NA	S	Protein of unknown function (DUF1456)
C1_01048	155864.EDL933_3200	1.7e-76	292.0	Escherichia	yehR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464										iECW_1372.ECW_m2324,iWFL_1372.ECW_m2324	Bacteria	1RG9F@1224,1S537@1236,3XPYC@561,COG4808@1,COG4808@2	NA|NA|NA	S	Protein of unknown function (DUF1307)
C1_01049	469008.B21_02009	0.0	1308.1	Escherichia	yehQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Bacteria	1R7Q0@1224,1S927@1236,3XNHR@561,COG4715@1,COG4715@2	NA|NA|NA	S	SWIM zinc finger
C1_01050	469008.B21_02008	2.4e-209	734.6	Escherichia	yehP												Bacteria	1QW9Y@1224,1T2TG@1236,3XNYJ@561,COG3552@1,COG3552@2	NA|NA|NA	S	VWA domain containing CoxE-like protein
C1_01051	469008.B21_02007	0.0	1500.0	Escherichia	yehM	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Bacteria	1QV44@1224,1T27M@1236,3XP4U@561,COG2425@1,COG2425@2	NA|NA|NA	S	protein containing a von Willebrand factor type A (vWA) domain
C1_01052	155864.EDL933_3194	2.3e-201	708.0	Escherichia	yehL			ko:K03924					ko00000,ko01000				Bacteria	1QDUZ@1224,1RQGT@1236,3XN4P@561,COG0714@1,COG0714@2	NA|NA|NA	S	ATPase activity
C1_01053	316407.85675231	3.9e-53	213.8	Gammaproteobacteria	yehK												Bacteria	1NWZ7@1224,1SP51@1236,2F5M5@1,33Y6A@2	NA|NA|NA		
C1_01054	316407.85675230	0.0	2326.2	Escherichia	yehI												Bacteria	1QWC3@1224,1S9SY@1236,3XNKN@561,COG3831@1,COG3831@2	NA|NA|NA	S	Domain of unknown function (DUF4132)
C1_01055	481805.EcolC_1532	0.0	2493.0	Escherichia	JD73_20480												Bacteria	1QWC3@1224,1S9SY@1236,3XNVN@561,COG3831@1,COG3831@2	NA|NA|NA	S	Proposed nucleic acid binding domain
C1_01056	155864.EDL933_3186	0.0	1380.9	Escherichia	metG	GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.10,6.1.1.20	ko:K01874,ko:K01890,ko:K06878	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R03660,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iEC042_1314.EC042_2346,iECUMN_1333.ECUMN_2446	Bacteria	1MUBY@1224,1RMYM@1236,3XN5R@561,COG0073@1,COG0073@2,COG0143@1,COG0143@2	NA|NA|NA	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1_01057	155864.EDL933_3185	6.8e-209	733.0	Escherichia	mrp	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K03593					ko00000,ko03029,ko03036				Bacteria	1MU7R@1224,1RMJF@1236,3XM4T@561,COG0489@1,COG0489@2	NA|NA|NA	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP
C1_01058	316407.85675227	2.4e-46	191.0	Escherichia	yehE												Bacteria	1NDQB@1224,1SEHZ@1236,2E71U@1,331KG@2,3XR50@561	NA|NA|NA	S	Protein of unknown function (DUF2574)
C1_01059	316407.85675226	2.3e-93	348.2	Escherichia	yehD	GO:0005575,GO:0005623,GO:0007155,GO:0008150,GO:0009289,GO:0009987,GO:0022610,GO:0031589,GO:0042710,GO:0042995,GO:0043708,GO:0043709,GO:0044010,GO:0044464,GO:0044764,GO:0051704,GO:0090605,GO:0090609											Bacteria	1N9MK@1224,1SFKQ@1236,3XQ6D@561,COG3539@1,COG3539@2	NA|NA|NA	NU	Part of the yehABCD fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches
C1_01060	316407.85675225	3.2e-121	441.0	Escherichia	yehC	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006457,GO:0006950,GO:0006974,GO:0007155,GO:0008150,GO:0009987,GO:0016043,GO:0022610,GO:0030030,GO:0030288,GO:0030313,GO:0031975,GO:0033554,GO:0042597,GO:0043711,GO:0044183,GO:0044464,GO:0050896,GO:0051716,GO:0061077,GO:0071840		ko:K07346,ko:K07353,ko:K15540					ko00000,ko02035,ko02044,ko03110				Bacteria	1R6JB@1224,1RRS0@1236,3XNUS@561,COG3121@1,COG3121@2	NA|NA|NA	NU	fimbrial chaperone
C1_01061	316407.85675224	0.0	1658.3	Escherichia	yehB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0006950,GO:0006974,GO:0008150,GO:0009279,GO:0009297,GO:0009987,GO:0015267,GO:0015288,GO:0015473,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0022803,GO:0022829,GO:0022857,GO:0030030,GO:0030031,GO:0030312,GO:0030313,GO:0031975,GO:0033554,GO:0043711,GO:0044085,GO:0044462,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071840,GO:0071944		ko:K07347	ko05133,map05133				ko00000,ko00001,ko02000,ko02035,ko02044	1.B.11.3			Bacteria	1MUHE@1224,1RMPU@1236,3XN71@561,COG3188@1,COG3188@2	NA|NA|NA	NU	outer membrane usher protein
C1_01062	316407.1736830	2.5e-181	641.3	Escherichia	yehA	GO:0005575,GO:0005623,GO:0007155,GO:0008150,GO:0009289,GO:0009987,GO:0022610,GO:0031589,GO:0042710,GO:0042995,GO:0043708,GO:0043709,GO:0044010,GO:0044464,GO:0044764,GO:0051704,GO:0090605,GO:0090609											Bacteria	1RAR0@1224,1S25S@1236,3XQ9J@561,COG3539@1,COG3539@2	NA|NA|NA	NU	Part of the yehABCD fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches
C1_01063	198214.SF2169	8.7e-59	232.6	Proteobacteria	yohN	GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0010033,GO:0010035,GO:0010038,GO:0010045,GO:0010243,GO:0030288,GO:0030313,GO:0031975,GO:0032025,GO:0033554,GO:0042221,GO:0042597,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:1901652,GO:1901698,GO:1901700											Bacteria	1RI8X@1224,COG5455@1,COG5455@2	NA|NA|NA	S	Nickel cobalt homeostasis protein RcnB
C1_01064	316407.1736829	5.5e-123	447.2	Escherichia	rcnA	GO:0000041,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0010035,GO:0010038,GO:0010045,GO:0015075,GO:0015099,GO:0015318,GO:0015562,GO:0015675,GO:0016020,GO:0016021,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0032025,GO:0034220,GO:0035444,GO:0042221,GO:0044425,GO:0044459,GO:0044464,GO:0046583,GO:0046873,GO:0046915,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098655,GO:0098660,GO:0098662		ko:K08970					ko00000,ko02000	2.A.52.2			Bacteria	1QDA1@1224,1RPK1@1236,3XQ5V@561,COG2215@1,COG2215@2	NA|NA|NA	U	Efflux system for nickel and cobalt
C1_01065	155864.EDL933_3177	1.3e-41	175.3	Escherichia	rcnR	GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K21600					ko00000,ko03000				Bacteria	1N6ZN@1224,1S75M@1236,3XR30@561,COG1937@1,COG1937@2	NA|NA|NA	K	Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter
C1_01066	316407.1736828	8.1e-140	503.1	Escherichia	thiM	GO:0003674,GO:0003824,GO:0004417,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0034654,GO:0036172,GO:0042364,GO:0042723,GO:0042724,GO:0042802,GO:0043094,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.50	ko:K00878	ko00730,ko01100,map00730,map01100	M00127	R04448	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000			iECABU_c1320.ECABU_c24340,iLF82_1304.LF82_2255,iNRG857_1313.NRG857_10680,iSFV_1184.SFV_2159,iSF_1195.SF2166,iSFxv_1172.SFxv_2394,iS_1188.S2291,ic_1306.c2631	Bacteria	1MVES@1224,1RRAE@1236,3XNG3@561,COG2145@1,COG2145@2	NA|NA|NA	F	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C1_01067	316407.1736827	3.4e-146	524.2	Escherichia	thiD	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008902,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009229,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0042357,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000			iG2583_1286.G2583_2635	Bacteria	1MU9J@1224,1RNFP@1236,3XP7H@561,COG0351@1,COG0351@2	NA|NA|NA	H	Phosphomethylpyrimidine kinase
C1_01068	316407.85675221	1.7e-153	548.5	Escherichia	yegX			ko:K07273					ko00000				Bacteria	1N792@1224,1SC72@1236,3XMFS@561,COG3757@1,COG3757@2	NA|NA|NA	M	lysozyme activity
C1_01069	155864.EDL933_3170	5.1e-136	490.3	Escherichia	yegW			ko:K03710,ko:K11922					ko00000,ko03000				Bacteria	1P6ZJ@1224,1RPDA@1236,3XN07@561,COG2188@1,COG2188@2	NA|NA|NA	K	Transcriptional regulator
C1_01070	155864.EDL933_3169	8e-182	642.9	Escherichia	yegV	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0019200,GO:0044237,GO:0044238,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046835,GO:0071704											Bacteria	1PDS9@1224,1RQE5@1236,3XNQU@561,COG0524@1,COG0524@2	NA|NA|NA	G	belongs to the carbohydrate kinase PfkB family
C1_01071	316407.85675219	1.2e-185	655.6	Escherichia	yegU												Bacteria	1NTUR@1224,1RMPE@1236,3XP4M@561,COG1397@1,COG1397@2	NA|NA|NA	O	hydrolase activity
C1_01072	469008.B21_01990	9.4e-239	832.4	Escherichia	yegT	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03289,ko:K03301,ko:K08218	ko01501,map01501	M00628			ko00000,ko00001,ko00002,ko02000	2.A.1.10.1,2.A.1.25,2.A.12		iECW_1372.ECW_m2299,iEcSMS35_1347.EcSMS35_3108,iWFL_1372.ECW_m2299	Bacteria	1MWI9@1224,1RMU5@1236,3XNA7@561,COG2211@1,COG2211@2	NA|NA|NA	P	nucleoside transporter
C1_01073	155864.EDL933_3166	6.7e-198	696.4	Escherichia	fbaB	GO:0003674,GO:0003824,GO:0004332,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016829,GO:0016830,GO:0016832,GO:0042802,GO:0044424,GO:0044444,GO:0044464	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000			iETEC_1333.ETEC_2236,iSBO_1134.SBO_0918,iUMNK88_1353.UMNK88_2640	Bacteria	1MW9N@1224,1RQHJ@1236,3XP5V@561,COG1830@1,COG1830@2	NA|NA|NA	F	fructose-bisphosphate aldolase activity
C1_01074	155864.EDL933_3165	6e-157	560.1	Escherichia	gatY	GO:0003674,GO:0003824,GO:0009025,GO:0016829,GO:0016830,GO:0016832	4.1.2.40	ko:K08302	ko00052,ko01100,map00052,map01100		R01069	RC00438,RC00439	ko00000,ko00001,ko01000			iAF1260.b3137,iAPECO1_1312.APECO1_3290,iB21_1397.B21_02955,iBWG_1329.BWG_2841,iEC042_1314.EC042_3431,iEC55989_1330.EC55989_3557,iECABU_c1320.ECABU_c35530,iECBD_1354.ECBD_0603,iECB_1328.ECB_03004,iECDH10B_1368.ECDH10B_3310,iECDH1ME8569_1439.ECDH1ME8569_3028,iECD_1391.ECD_03004,iECED1_1282.ECED1_3801,iECH74115_1262.ECH74115_4454,iECIAI1_1343.ECIAI1_3287,iECO103_1326.ECO103_3884,iECO111_1330.ECO111_3961,iECO26_1355.ECO26_4242,iECOK1_1307.ECOK1_3561,iECP_1309.ECP_3229,iECS88_1305.ECS88_3525,iECSE_1348.ECSE_3423,iECSP_1301.ECSP_4111,iECW_1372.ECW_m3407,iECs_1301.ECs4017,iEKO11_1354.EKO11_0580,iETEC_1333.ETEC_3404,iEcDH1_1363.EcDH1_0568,iEcE24377_1341.EcE24377A_3619,iEcHS_1320.EcHS_A3329,iEcolC_1368.EcolC_0561,iG2583_1286.G2583_2628,iG2583_1286.G2583_3861,iJO1366.b3137,iJR904.b3137,iLF82_1304.LF82_1138,iNRG857_1313.NRG857_15590,iUMN146_1321.UM146_00665,iUMNK88_1353.UMNK88_3896,iUTI89_1310.UTI89_C3568,iWFL_1372.ECW_m3407,iY75_1357.Y75_RS16275,iYL1228.KPN_03543,iZ_1308.Z4491,ic_1306.c3894	Bacteria	1MURX@1224,1RQUC@1236,3XPA4@561,COG0191@1,COG0191@2	NA|NA|NA	F	which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6- bisphosphate (TBP). Requires
C1_01075	316407.1736821	3.1e-242	844.0	Escherichia	gatZ	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034219,GO:0044425,GO:0044459,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944	5.1.3.40	ko:K02775,ko:K16371,ko:K21622	ko00052,ko01100,ko02060,map00052,map01100,map02060	M00279	R01069,R05570,R11623	RC00017,RC00438,RC00439,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.5.1		iE2348C_1286.E2348C_2240,iECIAI1_1343.ECIAI1_3280,iECO111_1330.ECO111_2811,iECO26_1355.ECO26_3004,iYL1228.KPN_03547	Bacteria	1MW3Q@1224,1RQAU@1236,3XNDM@561,COG4573@1,COG4573@2	NA|NA|NA	G	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
C1_01076	155864.EDL933_3163	5.6e-77	293.5	Gammaproteobacteria	gatA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0015791,GO:0015796,GO:0015850,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044424,GO:0044444,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090584	2.7.1.194,2.7.1.197,2.7.1.200,2.7.1.202,2.7.3.9	ko:K02768,ko:K02769,ko:K02770,ko:K02773,ko:K02798,ko:K02806,ko:K02821,ko:K08483,ko:K11189,ko:K11201,ko:K18531	ko00051,ko00052,ko00053,ko01100,ko01120,ko02060,map00051,map00052,map00053,map01100,map01120,map02060	M00273,M00274,M00279,M00283,M00306,M00550	R02704,R03232,R05570,R07671	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1,4.A.2.1.12,4.A.2.1.2,4.A.2.1.24,4.A.2.1.5,4.A.5.1,4.A.7.1,8.A.7		iECABU_c1320.ECABU_c47530,iECIAI39_1322.ECIAI39_0923,iECUMN_1333.ECUMN_4728,iEcSMS35_1347.EcSMS35_4666,ic_1306.c5284	Bacteria	1RDXB@1224,1S5QX@1236,COG1762@1,COG1762@2	NA|NA|NA	G	Phosphoenolpyruvate-dependent sugar phosphotransferase system
C1_01077	316407.1736810	1.1e-46	192.2	Gammaproteobacteria	gatB	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0015711,GO:0015749,GO:0015791,GO:0015796,GO:0015849,GO:0015850,GO:0015882,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0034220,GO:0035461,GO:0044424,GO:0044444,GO:0044464,GO:0046942,GO:0051179,GO:0051180,GO:0051181,GO:0051182,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090584,GO:0090585,GO:0098656,GO:1903825,GO:1905039	2.7.1.194,2.7.1.200	ko:K02774,ko:K02822	ko00052,ko00053,ko01100,ko01120,ko02060,map00052,map00053,map01100,map01120,map02060	M00279,M00283,M00550	R05570,R07671	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.5.1,4.A.7.1		iB21_1397.B21_01985,iECABU_c1320.ECABU_c24230,iECBD_1354.ECBD_1564,iECB_1328.ECB_02019,iECD_1391.ECD_02019,iECH74115_1262.ECH74115_3072,iECSP_1301.ECSP_2888,iECW_1372.ECW_m2294,iECs_1301.ECs2896,iEKO11_1354.EKO11_1661,iEcSMS35_1347.EcSMS35_0971,iSDY_1059.SDY_4363,iSF_1195.SF2155,iSFxv_1172.SFxv_2384,iS_1188.S2281,iWFL_1372.ECW_m2294,iZ_1308.Z3256,ic_1306.c2618	Bacteria	1RHBP@1224,1S5Y7@1236,COG3414@1,COG3414@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. The enzyme II complex composed of GatA, GatB and GatC is involved in galactitol transport
C1_01078	155864.EDL933_3161	5.1e-251	873.2	Gammaproteobacteria	gatC	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0015791,GO:0015796,GO:0015850,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090584		ko:K02775	ko00052,ko01100,ko02060,map00052,map01100,map02060	M00279	R05570	RC00017,RC03206	ko00000,ko00001,ko00002,ko02000	4.A.5.1		iEcolC_1368.EcolC_1555,iYL1228.KPN_03550	Bacteria	1MVRC@1224,1RQ76@1236,COG3775@1,COG3775@2	NA|NA|NA	G	system Galactitol-specific IIC component
C1_01079	155864.EDL933_3160	6.8e-195	686.4	Escherichia	gatD	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006059,GO:0006066,GO:0008150,GO:0008152,GO:0008270,GO:0008868,GO:0009056,GO:0009987,GO:0016052,GO:0016491,GO:0016614,GO:0016616,GO:0019400,GO:0019402,GO:0019404,GO:0019405,GO:0019407,GO:0019751,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046164,GO:0046174,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:1901575,GO:1901615,GO:1901616	1.1.1.14,1.1.1.251	ko:K00008,ko:K00094	ko00040,ko00051,ko00052,ko01100,map00040,map00051,map00052,map01100	M00014	R00875,R01896,R05571	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000			iEC55989_1330.EC55989_2345,iECNA114_1301.ECNA114_2182,iECSF_1327.ECSF_1973,iYL1228.KPN_03551	Bacteria	1MXTX@1224,1RN1R@1236,3XQPB@561,COG1063@1,COG1063@2	NA|NA|NA	E	5-dehydrogenase
C1_01080	198214.SF2150	2.7e-135	488.0	Gammaproteobacteria	gatR			ko:K02081,ko:K02436,ko:K02468					ko00000,ko03000				Bacteria	1MUJT@1224,1SZXU@1236,COG1349@1,COG1349@2	NA|NA|NA	K	Transcriptional
C1_01081	155864.EDL933_3158	1.1e-169	602.4	Escherichia	yegS	GO:0001727,GO:0003674,GO:0003824,GO:0004143,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0030258,GO:0044237,GO:0044238,GO:0044255,GO:0046834,GO:0071704	2.7.1.107	ko:K07029	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110		R02240	RC00002,RC00017	ko00000,ko00001,ko01000				Bacteria	1MY37@1224,1RMX9@1236,3XMZW@561,COG1597@1,COG1597@2	NA|NA|NA	F	the in vivo substrate is
C1_01082	198214.SF2148	1.8e-50	204.9	Gammaproteobacteria	yegR												Bacteria	1N9FT@1224,1SEIA@1236,2E6XX@1,331H8@2	NA|NA|NA		
C1_01083	316407.1736789	4.6e-268	929.9	Escherichia	yegQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K08303	ko05120,map05120				ko00000,ko00001,ko01000,ko01002				Bacteria	1MUQG@1224,1RNPY@1236,3XNIC@561,COG0826@1,COG0826@2	NA|NA|NA	O	peptidase activity
C1_01084	90371.CY43_15415	3.8e-34	150.6	Salmonella				ko:K19092					ko00000,ko02048				Bacteria	1QN9Z@1224,1SG0Y@1236,3ZNCN@590,COG3668@1,COG3668@2	NA|NA|NA	S	ParE toxin of type II toxin-antitoxin system, parDE
C1_01085	1114922.CIFAM_22_00530	6.7e-32	142.9	Citrobacter		GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007,GO:0097351		ko:K07746					ko00000,ko02048				Bacteria	1PDAC@1224,1SB7I@1236,3WYQZ@544,COG3609@1,COG3609@2	NA|NA|NA	K	Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH
C1_01086	198214.SF2145	5e-51	206.8	Gammaproteobacteria	yegP	GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360		ko:K09946					ko00000				Bacteria	1N0S6@1224,1S8R7@1236,COG3422@1,COG3422@2	NA|NA|NA	S	double-strand break repair
C1_01087	199310.c2605	1.1e-132	479.2	Escherichia													Bacteria	1MVCB@1224,1RMD0@1236,3XMHX@561,COG0745@1,COG0745@2	NA|NA|NA	K	Member of the two-component regulatory system BaeS BaeR which responds to envelope stress. Activates expression of periplasmic chaperone spy in response to spheroplast formation, indole and P pili protein PapG overexpression. Activates the mdtABCD and probably the CRISPR-Cas casABCDE-ygbT-ygbF operon
C1_01088	155864.EDL933_3153	3.4e-266	923.7	Escherichia													Bacteria	1N17V@1224,1RNI8@1236,3XMXB@561,COG0642@1,COG2205@2	NA|NA|NA	T	PhoQ Sensor
C1_01089	198214.SF2142	9.1e-251	872.5	Gammaproteobacteria	mdtD	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944		ko:K18326	ko02020,map02020				ko00000,ko00001,ko02000	2.A.1.3.26			Bacteria	1MUDA@1224,1RP1M@1236,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
C1_01090	469008.B21_01973	0.0	1912.5	Escherichia	mdtC	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006855,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015238,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015307,GO:0015318,GO:0015672,GO:0015893,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046618,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600		ko:K03296,ko:K07788,ko:K07789	ko02020,map02020	M00648			ko00000,ko00001,ko00002,ko02000	2.A.6.2			Bacteria	1MU48@1224,1RMBN@1236,3XNUD@561,COG0841@1,COG0841@2	NA|NA|NA	V	The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate
C1_01091	155864.EDL933_3150	0.0	1909.8	Escherichia	mdtB	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K03296,ko:K07788,ko:K07789	ko02020,map02020	M00648			ko00000,ko00001,ko00002,ko02000	2.A.6.2			Bacteria	1MU48@1224,1RMBN@1236,3XNGJ@561,COG0841@1,COG0841@2	NA|NA|NA	V	The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate
C1_01092	362663.ECP_2114	1.2e-217	762.3	Escherichia	mdtA	GO:0008150,GO:0008219,GO:0009987,GO:0012501		ko:K07799	ko02020,map02020	M00648			ko00000,ko00001,ko00002,ko02000	8.A.1			Bacteria	1MW65@1224,1RQ67@1236,3XM7P@561,COG0845@1,COG0845@2	NA|NA|NA	M	The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate
C1_01094	199310.c2599	1e-119	436.0	Escherichia	yegL												Bacteria	1MVUE@1224,1RZUX@1236,3XQ97@561,COG4245@1,COG4245@2	NA|NA|NA	S	von Willebrand factor type A domain
C1_01095	198214.SF2136	2.3e-122	444.9	Gammaproteobacteria	yegK												Bacteria	1RIEE@1224,1S8N0@1236,COG0631@1,COG0631@2	NA|NA|NA	T	Protein phosphatase 2C
C1_01096	469008.B21_01965	0.0	1258.4	Escherichia	yegI												Bacteria	1MWZX@1224,1S1BZ@1236,3XQX7@561,COG4248@1,COG4248@2	NA|NA|NA	S	protein kinase activity
C1_01097	155864.EDL933_3145	2.2e-254	884.4	Escherichia	yegD			ko:K04046,ko:K18640					ko00000,ko03110,ko04812	1.A.33			Bacteria	1MXBT@1224,1RN4U@1236,3XNI2@561,COG0443@1,COG0443@2	NA|NA|NA	O	ATP binding
C1_01098	316407.1736778	4.5e-160	570.5	Escherichia	alkA	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003824,GO:0003905,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006304,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008725,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0032131,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0035510,GO:0043170,GO:0043412,GO:0043733,GO:0043916,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	3.2.2.21	ko:K01247,ko:K13529	ko03410,map03410				ko00000,ko00001,ko01000,ko03000,ko03400				Bacteria	1N4N4@1224,1T1FZ@1236,3XMCS@561,COG0122@1,COG0122@2	NA|NA|NA	L	Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, 3-methylguanine, 7-methylguanine, O2- methylthymine, and O2-methylcytosine from the damaged DNA polymer formed by alkylation lesions
C1_01099	316407.1736771	0.0	2128.6	Escherichia	yegE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.1.1.80,2.7.13.3,2.7.7.65,3.1.1.61	ko:K07636,ko:K07716,ko:K13924,ko:K21084	ko02020,ko02026,ko02030,ko04112,map02020,map02026,map02030,map04112	M00434,M00506,M00511			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035				Bacteria	1MU2C@1224,1T2TF@1236,3XNYH@561,COG3447@1,COG3447@2,COG5001@1,COG5001@2,COG5002@1,COG5002@2	NA|NA|NA	T	diguanylate cyclase activity
C1_01100	155864.EDL933_3141	3.3e-115	421.0	Escherichia	udk	GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009224,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0043771,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046035,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100		R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000			iSBO_1134.SBO_0893	Bacteria	1MWCH@1224,1RNZG@1236,3XNQP@561,COG0572@1,COG0572@2	NA|NA|NA	F	CTP salvage
C1_01101	198214.SF2129	8.7e-107	392.9	Gammaproteobacteria	dcd	GO:0003674,GO:0003824,GO:0004170,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006244,GO:0006253,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008829,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009166,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009223,GO:0009262,GO:0009264,GO:0009314,GO:0009394,GO:0009628,GO:0009987,GO:0015949,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0033973,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046065,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0050896,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000			iPC815.YPO1525	Bacteria	1MV2J@1224,1RMCD@1236,COG0717@1,COG0717@2	NA|NA|NA	F	Belongs to the dCTP deaminase family
C1_01102	316407.1736768	0.0	1206.4	Escherichia	asmA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0032386,GO:0032879,GO:0032880,GO:0033157,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0051049,GO:0051223,GO:0060341,GO:0065007,GO:0070201,GO:0071944,GO:0090087,GO:0090313,GO:1903533,GO:1903827,GO:1905475		ko:K07289,ko:K07290					ko00000	9.B.121			Bacteria	1NVUY@1224,1RPFM@1236,3XMB9@561,COG2982@1,COG2982@2	NA|NA|NA	M	Involved in the inhibition of assembly of mutant ompF proteins. In general, could be involved in the assembly of outer membrane proteins
C1_01103	155864.EDL933_3136	1.8e-287	994.6	Escherichia	yegH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03699					ko00000,ko02042				Bacteria	1QTUN@1224,1RMTY@1236,3XN66@561,COG1253@1,COG1253@2	NA|NA|NA	P	flavin adenine dinucleotide binding
C1_01104	316407.85675205	2.2e-215	754.6	Escherichia	wza	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K01991,ko:K02237	ko02026,map02026	M00429			ko00000,ko00001,ko00002,ko02000,ko02044	1.B.18,3.A.11.1,3.A.11.2			Bacteria	1N7GP@1224,1RQSM@1236,3XNQG@561,COG1596@1,COG1596@2	NA|NA|NA	M	polysaccharide export protein
C1_01105	155864.EDL933_3134	1.5e-79	302.0	Escherichia	wzb	GO:0000271,GO:0003674,GO:0003824,GO:0004721,GO:0004725,GO:0005975,GO:0005976,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009242,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0033692,GO:0034637,GO:0034645,GO:0035335,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0046377,GO:0071704,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901576	3.1.3.48	ko:K01104					ko00000,ko01000				Bacteria	1N0DZ@1224,1S92S@1236,3XPM0@561,COG0394@1,COG0394@2	NA|NA|NA	T	low molecular weight
C1_01106	481805.EcolC_1581	0.0	1365.5	Escherichia	wzc	GO:0000271,GO:0003674,GO:0003824,GO:0004672,GO:0004713,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0005975,GO:0005976,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009242,GO:0009987,GO:0016020,GO:0016021,GO:0016051,GO:0016301,GO:0016310,GO:0016462,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0018108,GO:0018193,GO:0018212,GO:0019538,GO:0031224,GO:0031226,GO:0033692,GO:0034637,GO:0034645,GO:0036211,GO:0038083,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046377,GO:0046777,GO:0071704,GO:0071944,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901576		ko:K16692					ko00000,ko01000,ko01001				Bacteria	1MVI9@1224,1RNB0@1236,3XN7H@561,COG0489@1,COG0489@2,COG3206@1,COG3206@2	NA|NA|NA	DM	Tyrosine-protein kinase
C1_01107	155864.EDL933_3132	1.4e-161	575.5	Escherichia	wcaA	GO:0003674,GO:0003824,GO:0016740,GO:0016757											Bacteria	1QV3I@1224,1RY93@1236,3XN3F@561,COG0463@1,COG0463@2	NA|NA|NA	M	slime layer organization
C1_01108	155864.EDL933_3131	3.3e-83	314.3	Escherichia	wcaB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009001,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016407,GO:0016412,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.30	ko:K00640,ko:K03819	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000			iECW_1372.ECW_m2215,iWFL_1372.ECW_m2215	Bacteria	1MZSE@1224,1RRT1@1236,3XNK4@561,COG1045@1,COG1045@2	NA|NA|NA	E	serine O-acetyltransferase activity
C1_01109	155864.EDL933_3130	1.2e-235	822.0	Escherichia	wcaC	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008378,GO:0008610,GO:0008653,GO:0008921,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035250,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509		ko:K00754,ko:K13684					ko00000,ko01000,ko01003		GT4		Bacteria	1MWYH@1224,1S01S@1236,3XNNM@561,COG0438@1,COG0438@2	NA|NA|NA	M	lipopolysaccharide-1,6-galactosyltransferase activity
C1_01110	316407.85675202	1.1e-217	762.3	Escherichia	wcaD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K13620					ko00000				Bacteria	1R6FP@1224,1RQGA@1236,28KKV@1,2ZA5M@2,3XNAH@561	NA|NA|NA	S	slime layer organization
C1_01111	316407.85675201	1.9e-138	498.4	Escherichia	wcaE	GO:0003674,GO:0003824,GO:0016740,GO:0016757		ko:K13683					ko00000,ko01000,ko01003		GT2		Bacteria	1RB30@1224,1RPV7@1236,3XMBU@561,COG1216@1,COG1216@2	NA|NA|NA	S	colanic acid biosynthesis glycosyl transferase
C1_01112	198214.SF2117	1.2e-102	379.0	Gammaproteobacteria	wcaF	GO:0003674,GO:0003824,GO:0008374,GO:0016740,GO:0016746,GO:0016747	2.3.1.79	ko:K00661,ko:K03818					ko00000,ko01000				Bacteria	1R6A3@1224,1RQXV@1236,COG0110@1,COG0110@2	NA|NA|NA	S	colanic acid biosynthesis acetyltransferase wcaF
C1_01113	155864.EDL933_3126	1.4e-214	751.9	Escherichia	gmd	GO:0003674,GO:0003824,GO:0008446,GO:0016829,GO:0016835,GO:0016836	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100		R00888	RC00402	ko00000,ko00001,ko01000				Bacteria	1MUX0@1224,1RMIY@1236,3XMI8@561,COG1089@1,COG1089@2	NA|NA|NA	F	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
C1_01114	481805.EcolC_1589	9.5e-183	646.0	Escherichia	fcl	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0034641,GO:0034654,GO:0042350,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046368,GO:0046483,GO:0050577,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901576	1.1.1.271,4.2.1.47	ko:K01711,ko:K02377,ko:K16554	ko00051,ko00520,ko01100,ko05111,map00051,map00520,map01100,map05111		R00888,R05692	RC00402,RC01014	ko00000,ko00001,ko01000,ko02000	8.A.3.1		iECP_1309.ECP_2092,iLF82_1304.LF82_0626,iNRG857_1313.NRG857_10435,iUMNK88_1353.UMNK88_2597	Bacteria	1MUGT@1224,1RMPQ@1236,3XMRE@561,COG0451@1,COG0451@2	NA|NA|NA	GM	Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction
C1_01115	155864.EDL933_3124	4.1e-86	323.9	Escherichia	gmm	GO:0000287,GO:0003674,GO:0003824,GO:0004553,GO:0005488,GO:0015926,GO:0016787,GO:0016798,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0047917	3.6.1.55	ko:K03207,ko:K03574					ko00000,ko01000,ko03400			iECBD_1354.ECBD_1604	Bacteria	1MZDA@1224,1S6M4@1236,3XPJG@561,COG1051@1,COG1051@2	NA|NA|NA	F	Belongs to the Nudix hydrolase family
C1_01116	155864.EDL933_3123	6.7e-234	816.2	Escherichia	wcaI	GO:0003674,GO:0003824,GO:0016740,GO:0016757	2.4.1.14	ko:K00696,ko:K00754,ko:K03208	ko00500,ko01100,map00500,map01100		R00766	RC00005,RC00028,RC02748	ko00000,ko00001,ko01000		GT4		Bacteria	1QV3H@1224,1T26X@1236,3XNR0@561,COG0297@1,COG0297@2	NA|NA|NA	G	slime layer organization
C1_01117	199310.c2575	1.4e-275	954.9	Escherichia	cpsB	GO:0000271,GO:0003674,GO:0003824,GO:0004475,GO:0005975,GO:0005976,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0008152,GO:0008905,GO:0008928,GO:0009058,GO:0009059,GO:0009242,GO:0009628,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016772,GO:0016779,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0046377,GO:0050896,GO:0070568,GO:0071704,GO:1901135,GO:1901137,GO:1901576	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000			iE2348C_1286.E2348C_2191,iEC042_1314.EC042_2286,iECIAI1_1343.ECIAI1_2124,iECO26_1355.ECO26_2960,iECSE_1348.ECSE_2323,iECW_1372.ECW_m2206,iEKO11_1354.EKO11_1746,iEcE24377_1341.EcE24377A_2342,iLF82_1304.LF82_0345,iNRG857_1313.NRG857_10420,iWFL_1372.ECW_m2206	Bacteria	1MV39@1224,1RNQI@1236,3XMD8@561,COG0662@1,COG0662@2,COG0836@1,COG0836@2	NA|NA|NA	GM	mannose-1-phosphate guanylyltransferase
C1_01118	316407.85675199	3.7e-265	920.2	Escherichia	manB	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	5.4.2.2,5.4.2.8	ko:K01840,ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000			iECS88_1305.ECS88_2145,iECUMN_1333.ECUMN_2384,iUTI89_1310.UTI89_C2321	Bacteria	1MUA5@1224,1RMU8@1236,3XN19@561,COG1109@1,COG1109@2	NA|NA|NA	F	Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS
C1_01119	469008.B21_01942	1.2e-268	931.8	Escherichia	wcaJ	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009242,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016772,GO:0016780,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046377,GO:0071704,GO:0071944,GO:0089702,GO:1901135,GO:1901137,GO:1901576		ko:K03606	ko05111,map05111				ko00000,ko00001				Bacteria	1MV6W@1224,1RMMN@1236,3XMRD@561,COG2148@1,COG2148@2	NA|NA|NA	M	Is the initiating enzyme for colanic acid (CA) synthesis. Catalyzes the transfer of the glucose-1-phosphate moiety from UDP-Glc onto the carrier lipid undecaprenyl phosphate (C55-P), forming a phosphoanhydride bond yielding to glucosyl- pyrophosphoryl-undecaprenol (Glc-PP-C55). Also possesses a weak galactose-1-P transferase activity
C1_01120	199310.c2571	3.7e-255	887.1	Escherichia	wzxC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03328,ko:K16694,ko:K16695					ko00000,ko02000	2.A.66.2,2.A.66.2.6,2.A.66.2.7		iYO844.BSU35600	Bacteria	1R9I0@1224,1RP3V@1236,3XPF6@561,COG2244@1,COG2244@2	NA|NA|NA	S	lipopolysaccharide biosynthetic process
C1_01121	316407.85675198	7.7e-241	839.3	Escherichia	wcaK			ko:K16710					ko00000			iECSF_1327.ECSF_1934,iSBO_1134.SBO_0872	Bacteria	1MXWP@1224,1RRDB@1236,3XMBT@561,COG2327@1,COG2327@2	NA|NA|NA	S	slime layer organization
C1_01122	316407.1736747	6.5e-229	799.7	Escherichia	wcaL	GO:0003674,GO:0003824,GO:0016740,GO:0016757		ko:K16703					ko00000,ko01000,ko01003		GT4		Bacteria	1MVKK@1224,1RQ8J@1236,3XNDB@561,COG0438@1,COG0438@2	NA|NA|NA	M	colanic acid biosynthesis glycosyl transferase
C1_01123	481805.EcolC_1598	6e-263	912.9	Escherichia	wcaM			ko:K16711					ko00000				Bacteria	1R6F2@1224,1RZKI@1236,2C3PH@1,2Z7QB@2,3XMQI@561	NA|NA|NA	M	slime layer organization
C1_01124	155864.EDL933_3114	1.2e-188	665.6	Escherichia	gne	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016020,GO:0016051,GO:0016853,GO:0016854,GO:0016857,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	5.1.3.26	ko:K19997					ko00000,ko01000				Bacteria	1MX2J@1224,1RPHW@1236,3XMKU@561,COG0451@1,COG0451@2	NA|NA|NA	M	Polysaccharide biosynthesis protein
C1_01125	155864.EDL933_3113	1e-162	579.3	Escherichia	galU	GO:0003674,GO:0003824,GO:0003983,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016772,GO:0016779,GO:0044424,GO:0044444,GO:0044464,GO:0051748,GO:0070569	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000			iECIAI39_1322.ECIAI39_1571	Bacteria	1MV5F@1224,1RMHB@1236,3XNJT@561,COG1210@1,COG1210@2	NA|NA|NA	M	UTP:glucose-1-phosphate uridylyltransferase activity
C1_01126	1408473.JHXO01000009_gene3476	1.2e-59	237.7	Bacteroidia													Bacteria	2FNUG@200643,4NEGZ@976,COG2244@1,COG2244@2	NA|NA|NA	S	Psort location CytoplasmicMembrane, score 10.00
C1_01127	385682.AFSL01000054_gene444	4.6e-106	391.7	Marinilabiliaceae			1.12.98.1	ko:K00441	ko00680,ko01100,ko01120,map00680,map01100,map01120		R03025	RC02628	ko00000,ko00001,ko01000				Bacteria	2G1CB@200643,3XKTG@558415,4NJHS@976,COG1035@1,COG1035@2	NA|NA|NA	C	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term
C1_01128	1131812.JQMS01000001_gene301	2.3e-79	302.8	Flavobacterium			2.2.1.9	ko:K02551	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08165	RC02186	ko00000,ko00001,ko00002,ko01000				Bacteria	1I1AW@117743,2NY5E@237,4NEMD@976,COG2327@1,COG2327@2	NA|NA|NA	S	Polysaccharide pyruvyl transferase
C1_01129	1141662.OOA_18049	2.7e-55	222.6	Gammaproteobacteria													Bacteria	1N72Z@1224,1RRQJ@1236,COG1216@1,COG1216@2	NA|NA|NA	M	Glycosyltransferases involved in cell wall biogenesis
C1_01130	1002367.HMPREF0673_01187	1.4e-59	236.5	Bacteroidia													Bacteria	2FSNZ@200643,4NJH2@976,COG3774@1,COG3774@2	NA|NA|NA	M	glycosyltransferase K00754
C1_01132	502347.ESCAB7627_2262	3.3e-168	597.8	Gammaproteobacteria			2.7.8.12	ko:K09809,ko:K19354					ko00000,ko01000,ko01003,ko01005		GT2		Bacteria	1QXS8@1224,1T3HW@1236,COG1216@1,COG1216@2	NA|NA|NA	S	Glycosyltransferase like family 2
C1_01133	502347.ESCAB7627_2263	1.8e-201	708.4	Escherichia	glf	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008767,GO:0009273,GO:0009987,GO:0016020,GO:0016853,GO:0016866,GO:0030312,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0071554,GO:0071766,GO:0071840,GO:0071944,GO:0097159,GO:1901265,GO:1901363	5.4.99.9	ko:K01854	ko00052,ko00520,map00052,map00520		R00505,R09009	RC00317,RC02396	ko00000,ko00001,ko01000			iNJ661.Rv3809c	Bacteria	1MV4H@1224,1RPMY@1236,3XQDU@561,COG0562@1,COG0562@2	NA|NA|NA	J	Catalyzes the interconversion through a 2-keto intermediate of uridine diphosphogalactopyranose (UDP-GalP) into uridine diphosphogalactofuranose (UDP-GalF)
C1_01134	502347.ESCAB7627_2264	5.1e-162	577.0	Gammaproteobacteria	glfT1	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0008378,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016740,GO:0016757,GO:0016758,GO:0034645,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0045229,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:1901576	2.4.1.287	ko:K16649					ko00000,ko01000,ko01003		GT2		Bacteria	1NE2P@1224,1RYPV@1236,COG1216@1,COG1216@2	NA|NA|NA	S	Glycosyl Transferase
C1_01135	199310.c2556	4.2e-264	916.8	Escherichia	gnd	GO:0003674,GO:0003824,GO:0004616,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006081,GO:0006082,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019362,GO:0019520,GO:0019521,GO:0019637,GO:0019682,GO:0019693,GO:0019752,GO:0032787,GO:0034641,GO:0042802,GO:0042803,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046176,GO:0046177,GO:0046395,GO:0046483,GO:0046496,GO:0046983,GO:0051156,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072329,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000			iECS88_1305.ECS88_2128,iECW_1372.ECW_m2189,iEKO11_1354.EKO11_1765,iPC815.YPO1541,iWFL_1372.ECW_m2189	Bacteria	1MVV8@1224,1RM7P@1236,3XN7J@561,COG0362@1,COG0362@2	NA|NA|NA	F	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C1_01136	199310.c2555	1.6e-213	748.4	Escherichia	ugd	GO:0000271,GO:0003674,GO:0003824,GO:0003979,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009242,GO:0009987,GO:0016051,GO:0016491,GO:0016614,GO:0016616,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0046377,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901576	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000			iEC55989_1330.EC55989_2287	Bacteria	1MW5U@1224,1RMVW@1236,3XMFE@561,COG1004@1,COG1004@2	NA|NA|NA	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C1_01137	199310.c2554	4.8e-158	563.9	Escherichia	wzzB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K05789,ko:K05790					ko00000,ko01005			iAF1260.b3785,iB21_1397.B21_03612,iBWG_1329.BWG_3467,iECBD_1354.ECBD_4254,iECB_1328.ECB_03663,iECDH10B_1368.ECDH10B_3974,iECDH1ME8569_1439.ECDH1ME8569_3667,iECD_1391.ECD_03663,iECH74115_1262.ECH74115_5218,iECIAI1_1343.ECIAI1_3972,iECSP_1301.ECSP_4833,iECUMN_1333.ECUMN_4310,iETEC_1333.ETEC_4067,iEcDH1_1363.EcDH1_4191,iEcE24377_1341.EcE24377A_4296,iEcHS_1320.EcHS_A4002,iJO1366.b3785,iSF_1195.SF3859,iS_1188.S3901,iSbBS512_1146.SbBS512_E4136,iUMNK88_1353.UMNK88_4594,iY75_1357.Y75_RS18155	Bacteria	1MVM1@1224,1RNAU@1236,3XPAY@561,COG3765@1,COG3765@2	NA|NA|NA	M	Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules
C1_01138	155864.EDL933_3098	2.1e-111	408.3	Escherichia	hisI	GO:0000105,GO:0000287,GO:0003674,GO:0003824,GO:0004635,GO:0004636,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0043167,GO:0043169,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052803,GO:0071704,GO:0071944,GO:0075136,GO:0075139,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.5.4.19,3.5.4.25,3.6.1.31,5.3.1.16	ko:K01496,ko:K01497,ko:K01523,ko:K01814,ko:K11755	ko00340,ko00740,ko00790,ko01100,ko01110,ko01230,ko02024,map00340,map00740,map00790,map01100,map01110,map01230,map02024	M00026,M00125	R00425,R04035,R04037,R04640	RC00002,RC00293,RC00945,RC01055,RC02504	ko00000,ko00001,ko00002,ko01000			iECNA114_1301.ECNA114_0880,iECW_1372.ECW_m2186,iEKO11_1354.EKO11_1768,iHN637.CLJU_RS05760,iSB619.SA_RS14110,iUMN146_1321.UM146_06665,iWFL_1372.ECW_m2186	Bacteria	1MW67@1224,1RMV4@1236,3XNZI@561,COG0139@1,COG0139@2,COG0140@1,COG0140@2	NA|NA|NA	F	Histidine biosynthesis bifunctional protein HisIE
C1_01139	481805.EcolC_1617	2.8e-145	521.2	Escherichia	hisF	GO:0000105,GO:0000107,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009382,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234	3.5.4.19,3.6.1.31	ko:K01663,ko:K02500,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037,R04558	RC00002,RC00010,RC01055,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000			iECO111_1330.ECO111_2749,iEcolC_1368.EcolC_1617,iHN637.CLJU_RS05755,iLJ478.TM1036,iSB619.SA_RS14115,iYL1228.KPN_02481	Bacteria	1MUS0@1224,1RPJQ@1236,3XNNT@561,COG0107@1,COG0107@2	NA|NA|NA	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
C1_01140	469008.B21_01912	2.4e-133	481.5	Escherichia	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0033554,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0050896,GO:0051716,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000			iSBO_1134.SBO_0850,iSDY_1059.SDY_2217	Bacteria	1MW6S@1224,1RN3M@1236,3XNGK@561,COG0106@1,COG0106@2	NA|NA|NA	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C1_01141	199310.c2550	1.3e-110	405.6	Escherichia	hisH	GO:0000105,GO:0000107,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009382,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234		ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000			iECED1_1282.ECED1_2372,iPC815.YPO1545,iYL1228.KPN_02479	Bacteria	1MU4X@1224,1RRP3@1236,3XNQK@561,COG0118@1,COG0118@2	NA|NA|NA	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C1_01142	469008.B21_01910	7.2e-208	729.6	Escherichia	hisB	GO:0000105,GO:0000287,GO:0003674,GO:0003824,GO:0004401,GO:0004424,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034200,GO:0034641,GO:0040007,GO:0042578,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23,2.6.1.9,3.1.3.15,3.1.3.82,3.1.3.83,4.2.1.19	ko:K00013,ko:K00817,ko:K01089,ko:K01693,ko:K03273	ko00340,ko00350,ko00360,ko00400,ko00401,ko00540,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00540,map00960,map01100,map01110,map01130,map01230	M00026,M00064	R00694,R00734,R01158,R01163,R03012,R03013,R03243,R03457,R05647,R09771	RC00006,RC00017,RC00099,RC00242,RC00463,RC00888,RC00932	ko00000,ko00001,ko00002,ko01000,ko01005,ko01007			iECO111_1330.ECO111_2746,iECS88_1305.ECS88_2121,iETEC_1333.ETEC_0196,iJN746.PP_0289,iLJ478.TM1039,iSB619.SA_RS14130,iUMNK88_1353.UMNK88_2570	Bacteria	1MWBS@1224,1RPA9@1236,3XMA4@561,COG0131@1,COG0131@2,COG0241@1,COG0241@2	NA|NA|NA	E	Histidine biosynthesis bifunctional protein HisB
C1_01143	316407.1736699	1.2e-199	702.2	Escherichia	hisC	GO:0000105,GO:0003674,GO:0003824,GO:0004400,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23,2.6.1.9	ko:K00013,ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R01158,R01163,R03012,R03243	RC00006,RC00099,RC00242,RC00463,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007			iECO111_1330.ECO111_2745,iSDY_1059.SDY_2220,iSSON_1240.SSON_2092	Bacteria	1MW7I@1224,1RP4T@1236,3XN8C@561,COG0079@1,COG0079@2	NA|NA|NA	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C1_01144	199310.c2547	2.5e-234	817.8	Escherichia	hisD	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23,1.1.1.308	ko:K00013,ko:K15509	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000			iECUMN_1333.ECUMN_2362,iG2583_1286.G2583_2541,iUTI89_1310.UTI89_C2293,ic_1306.c2547	Bacteria	1MUUF@1224,1RMZD@1236,3XMXY@561,COG0141@1,COG0141@2	NA|NA|NA	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C1_01145	199310.c2546	6.6e-162	576.6	Escherichia	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000			iECSF_1327.ECSF_1909	Bacteria	1MUCY@1224,1RNAX@1236,3XNIV@561,COG0040@1,COG0040@2	NA|NA|NA	F	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
C1_01146	198214.SF2079	1.1e-37	162.2	Gammaproteobacteria	yefM	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0015643,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042710,GO:0043565,GO:0044010,GO:0044764,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051704,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	2.3.1.15	ko:K08591,ko:K19159	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004,ko02048				Bacteria	1N6X6@1224,1SDQ0@1236,COG2161@1,COG2161@2	NA|NA|NA	D	Antitoxin component of a toxin-antitoxin (TA) module
C1_01147	198214.SF2076	1.3e-43	181.8	Gammaproteobacteria	yoeB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0006139,GO:0006379,GO:0006401,GO:0006402,GO:0006417,GO:0006446,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016071,GO:0016458,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0017148,GO:0019222,GO:0019439,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0034655,GO:0042710,GO:0043021,GO:0043024,GO:0043170,GO:0044010,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044764,GO:0044877,GO:0045947,GO:0046483,GO:0046700,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051704,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0098795,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:2000112,GO:2000113		ko:K19158					ko00000,ko01000,ko02048				Bacteria	1MZBP@1224,1S99Z@1236,COG4115@1,COG4115@2	NA|NA|NA	S	Addiction module toxin, Txe YoeB
C1_01148	155864.EDL933_3090	3.2e-155	554.3	Escherichia	yeeZ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Bacteria	1MWVJ@1224,1RNDT@1236,3XMI9@561,COG0451@1,COG0451@2	NA|NA|NA	GM	coenzyme binding
C1_01149	199310.c2542	2.4e-178	631.3	Escherichia	yeeY	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576		ko:K10972					ko00000,ko03000				Bacteria	1MZTA@1224,1RQT0@1236,3XN23@561,COG0583@1,COG0583@2	NA|NA|NA	K	transcriptional regulator
C1_01150	155864.EDL933_3087	2e-250	871.3	Escherichia	yeeF	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006928,GO:0008150,GO:0008324,GO:0008519,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015101,GO:0015203,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015489,GO:0015672,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0016020,GO:0022804,GO:0022857,GO:0022890,GO:0034220,GO:0040011,GO:0044464,GO:0048870,GO:0051179,GO:0051234,GO:0051674,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072488,GO:0098655,GO:0098660,GO:0098662,GO:1902047,GO:1902600		ko:K14052					ko00000,ko02000	2.A.3.1.13		iSBO_1134.SBO_1766	Bacteria	1MXNJ@1224,1RMKV@1236,3XN4G@561,COG0531@1,COG0531@2	NA|NA|NA	E	putrescine transmembrane transporter activity
C1_01151	481805.EcolC_1627	8.3e-182	642.9	Gammaproteobacteria	yeeE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K07112					ko00000				Bacteria	1MWWP@1224,1RR58@1236,COG2391@1,COG2391@2	NA|NA|NA	S	Inner membrane protein PRK11099
C1_01152	155864.EDL933_3085	1.3e-34	151.8	Gammaproteobacteria	yeeD	GO:0008150,GO:0009987,GO:0019725,GO:0042592,GO:0048878,GO:0055082,GO:0065007,GO:0065008		ko:K04085,ko:K07112	ko04122,map04122				ko00000,ko00001,ko01000,ko03016				Bacteria	1N4X7@1224,1SCWW@1236,COG0425@1,COG0425@2	NA|NA|NA	O	Sulfurtransferase TusA
C1_01153	316407.1736685	3.7e-284	983.4	Escherichia	sbcB	GO:0000175,GO:0000287,GO:0000738,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004532,GO:0004536,GO:0004540,GO:0005488,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0008852,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016829,GO:0016835,GO:0016895,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0046872,GO:0051575,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0140097,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575	3.1.11.1	ko:K01141	ko03430,map03430				ko00000,ko00001,ko01000,ko03400				Bacteria	1MV0U@1224,1RM85@1236,3XMEP@561,COG2925@1,COG2925@2	NA|NA|NA	L	Degrades single-stranded DNA (ssDNA) in a highly processive manner. Also functions as a DNA deoxyribophosphodiesterase that releases deoxyribose-phosphate moieties following the cleavage of DNA at an apurinic apyrimidinic (AP) site by either an AP endonuclease or AP lyase
C1_01154	362663.ECP_2054	4.8e-221	773.5	Escherichia	dacC	GO:0000270,GO:0003674,GO:0003824,GO:0004175,GO:0004180,GO:0005488,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008360,GO:0008658,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016787,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100				ko00000,ko00001,ko01000,ko01002,ko01011			iEC55989_1330.EC55989_2269,iSFV_1184.SFV_0694,iSbBS512_1146.SbBS512_E2506	Bacteria	1MUU7@1224,1RMJA@1236,3XP01@561,COG1686@1,COG1686@2	NA|NA|NA	M	Belongs to the peptidase S11 family
C1_01155	155864.EDL933_3081	1.3e-89	335.5	Escherichia	sbmC	GO:0003674,GO:0004857,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006275,GO:0006950,GO:0006974,GO:0008150,GO:0008156,GO:0008657,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010556,GO:0010558,GO:0010605,GO:0010911,GO:0019219,GO:0019222,GO:0019899,GO:0030234,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032780,GO:0033554,GO:0042030,GO:0043086,GO:0043462,GO:0044092,GO:0044424,GO:0044464,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051336,GO:0051346,GO:0051716,GO:0060255,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0072586,GO:0080090,GO:0090329,GO:0098772,GO:2000104,GO:2000112,GO:2000113,GO:2000371,GO:2000372		ko:K07470,ko:K13652					ko00000,ko03000				Bacteria	1RG5K@1224,1S4HI@1236,3XMF6@561,COG3449@1,COG3449@2	NA|NA|NA	L	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
C1_01156	316407.1736674	8.8e-198	696.0	Escherichia	yeeA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1MUWE@1224,1RNFT@1236,3XM9R@561,COG1289@1,COG1289@2	NA|NA|NA	S	transmembrane transporter activity
C1_01157	155864.EDL933_3079	3.2e-50	204.1	Escherichia	yeeX	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K09802					ko00000				Bacteria	1RH0U@1224,1S6XT@1236,3XPNT@561,COG2926@1,COG2926@2	NA|NA|NA	S	Belongs to the UPF0265 family
C1_01158	199310.c4577	4.1e-21	106.7	Gammaproteobacteria													Bacteria	1N76M@1224,1SFFA@1236,2C6P3@1,32ZZF@2	NA|NA|NA	S	Enterobacterial protein of unknown function (DUF957)
C1_01159	199310.c2532	2.6e-64	251.1	Gammaproteobacteria	cbtA	GO:0003674,GO:0005488,GO:0005515,GO:0008092,GO:0008150,GO:0008219,GO:0009987,GO:0012501		ko:K18837					ko00000,ko02048				Bacteria	1REKF@1224,1S4ED@1236,2C4I5@1,30KUQ@2	NA|NA|NA	S	inhibits FtsZ GTP-dependent polymerization and GTPase activity as well as MreB ATP-dependent polymerization. Binds to both the N- and C-terminus of FtsZ, likely blocking its polymerization. Overexpression results in inhibition of growth in liquid cultures and decrease in colony formation
C1_01160	155864.EDL933_3074	2.3e-40	171.0	Gammaproteobacteria	yeeU			ko:K18838					ko00000,ko02048				Bacteria	1RI9Y@1224,1S8EC@1236,2BMAS@1,32FUR@2	NA|NA|NA	S	CbeA_antitoxin, type IV, cytoskeleton bundling-enhancing factor A
C1_01161	199310.c3673	2e-35	154.5	Escherichia													Bacteria	1N89D@1224,1SFG4@1236,2CZYD@1,333DH@2,3XR4B@561	NA|NA|NA	S	Escherichia coli O157 H7 ortholog
C1_01162	362663.ECP_3013	3.2e-83	314.3	Escherichia	radC			ko:K03630					ko00000				Bacteria	1MW2D@1224,1S0RG@1236,3XQMM@561,COG2003@1,COG2003@2	NA|NA|NA	E	Belongs to the UPF0758 family
C1_01163	362663.ECP_3012	4.2e-83	313.9	Escherichia	klcA_1												Bacteria	1REBZ@1224,1S3SZ@1236,2921C@1,2ZPKK@2,3XQ53@561	NA|NA|NA	S	Escherichia coli O157 H7 ortholog z1656
C1_01164	199310.c3668	5.4e-155	553.5	Escherichia													Bacteria	1MVTR@1224,1RMPH@1236,28H9R@1,2Z7MD@2,3XNIG@561	NA|NA|NA	S	Escherichia coli O157 H7 ortholog z1655
C1_01165	199310.c3666	4.3e-33	146.7	Escherichia	ykfF												Bacteria	1NAPS@1224,1SE5M@1236,2DPNE@1,332RS@2,3XRDY@561	NA|NA|NA	S	Escherichia coli K-12 ortholog b0249
C1_01166	199310.c1275	4.9e-81	307.0	Gammaproteobacteria													Bacteria	1RJ9M@1224,1S62B@1236,2AU4N@1,31JRB@2	NA|NA|NA		
C1_01167	199310.c3664	0.0	1549.3	Escherichia	yeeR	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.3.1.71,2.1.1.334	ko:K00223,ko:K21310	ko00100,ko00920,ko01100,ko01130,map00100,map00920,map01100,map01130	M00102	R05641,R11546	RC00237,RC02653	ko00000,ko00001,ko00002,ko01000				Bacteria	1R7V9@1224,1S79P@1236,3XQBV@561,COG2020@1,COG2020@2	NA|NA|NA	O	methyltransferase activity
C1_01168	316407.85675183	0.0	1352.8	Gammaproteobacteria	flu	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944		ko:K12687	ko02026,map02026				ko00000,ko00001,ko02000,ko02044	1.B.12.8.2			Bacteria	1QNFZ@1224,1RR10@1236,COG3468@1,COG3468@2	NA|NA|NA	MU	Adhesin of bacterial autotransporter system, probable stalk
C1_01169	198214.SF2990	2.1e-160	571.6	Gammaproteobacteria				ko:K06946					ko00000				Bacteria	1NG19@1224,1RPV6@1236,COG3596@1,COG3596@2	NA|NA|NA	S	GTP-binding protein
C1_01170	199310.c3652	1.3e-242	845.5	Gammaproteobacteria	yfjI	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Bacteria	1N636@1224,1RZVN@1236,COG4983@1,COG4983@2	NA|NA|NA	T	Protein of unknown function (DUF3987)
C1_01171	362663.ECP_3001	3.1e-107	394.4	Gammaproteobacteria													Bacteria	1RBZT@1224,1S22J@1236,28PZ6@1,2ZCIN@2	NA|NA|NA		
C1_01172	362663.ECP_3000	3.3e-29	133.7	Gammaproteobacteria				ko:K07733					ko00000,ko03000				Bacteria	1N6XK@1224,1SE2K@1236,COG3311@1,COG3311@2	NA|NA|NA	K	transcriptional regulator
C1_01173	199310.c2500	2.9e-107	394.4	Gammaproteobacteria													Bacteria	1MZGE@1224,1S91C@1236,2CZQX@1,32T6W@2	NA|NA|NA	S	Inovirus Gp2
C1_01174	199310.c3647	1.2e-62	245.7	Gammaproteobacteria													Bacteria	1N0KW@1224,1S8UK@1236,2E2VY@1,32XXE@2	NA|NA|NA	S	Probable zinc-ribbon
C1_01176	571.MC52_00735	1.4e-62	245.7	Gammaproteobacteria	Z012_08285			ko:K07486					ko00000				Bacteria	1MXKJ@1224,1RSCP@1236,COG3547@1,COG3547@2	NA|NA|NA	L	Transposase
C1_01177	199310.c2498	9.1e-71	272.7	Gammaproteobacteria													Bacteria	1NISC@1224,1SHVY@1236,2E2VY@1,33CH0@2	NA|NA|NA	S	Probable zinc-ribbon
C1_01178	155864.EDL933_1049	8.5e-49	199.5	Gammaproteobacteria				ko:K07483					ko00000				Bacteria	1NINX@1224,1SUIS@1236,COG2963@1,COG2963@2	NA|NA|NA	L	Transposase
C1_01179	316407.1742285	7e-217	759.6	Escherichia	insI1	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004803,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0030983,GO:0032135,GO:0032196,GO:0032991,GO:0032993,GO:0034641,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363		ko:K07482					ko00000				Bacteria	1PP49@1224,1RN7B@1236,3XQB0@561,COG2826@1,COG2826@2	NA|NA|NA	L	Transposase insI for insertion sequence element
C1_01180	481805.EcolC_3407	6.4e-60	236.5	Escherichia				ko:K07483					ko00000				Bacteria	1MZ5C@1224,1S9KN@1236,3XR3I@561,COG2963@1,COG2963@2	NA|NA|NA	L	Putative ATPase subunit of terminase (gpP-like)
C1_01181	178901.AmDm5_3104	5.6e-177	626.7	Alphaproteobacteria				ko:K07483,ko:K07497					ko00000				Bacteria	1MY62@1224,2U0GY@28211,COG2801@1,COG2801@2	NA|NA|NA	L	COG2801 Transposase and inactivated derivatives
C1_01182	1440052.EAKF1_ch0283	5.5e-59	233.4	Escherichia	insC			ko:K07483					ko00000				Bacteria	1N0V0@1224,1S7WV@1236,3XRHH@561,COG2963@1,COG2963@2	NA|NA|NA	L	transposase activity
C1_01183	155864.EDL933_3064	2e-97	361.7	Escherichia	cobU	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008819,GO:0008820,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016779,GO:0033554,GO:0044237,GO:0050896,GO:0051716,GO:0070568	2.7.1.156,2.7.7.62,6.3.5.10	ko:K02231,ko:K02232	ko00860,ko01100,map00860,map01100	M00122	R05221,R05222,R05225,R06558	RC00002,RC00010,RC00428,RC01302	ko00000,ko00001,ko00002,ko01000			iECIAI1_1343.ECIAI1_2074,iECSE_1348.ECSE_2277,iECW_1372.ECW_m2165,iETEC_1333.ETEC_2103,iEcE24377_1341.EcE24377A_2275,iEcSMS35_1347.EcSMS35_1131,iEcolC_1368.EcolC_1635,iLF82_1304.LF82_0337,iSDY_1059.SDY_2240,iWFL_1372.ECW_m2165	Bacteria	1RH0A@1224,1S42M@1236,3XPK4@561,COG2087@1,COG2087@2	NA|NA|NA	H	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
C1_01184	316407.1736653	6.7e-128	463.4	Escherichia	cobS	GO:0005575,GO:0005623,GO:0005886,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016020,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000			iECH74115_1262.ECH74115_2837,iECO103_1326.ECO103_2453,iECSP_1301.ECSP_2657,iECs_1301.ECs2787,iG2583_1286.G2583_2502,iUTI89_1310.UTI89_C2230,iZ_1308.Z3152,ic_1306.c2478	Bacteria	1RHCC@1224,1S4TE@1236,3XN3V@561,COG0368@1,COG0368@2	NA|NA|NA	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C1_01185	316407.1736652	2.9e-196	691.0	Escherichia	cobT	GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.4.2.21,6.3.5.11,6.3.5.9	ko:K00768,ko:K02224	ko00860,ko01100,ko01120,map00860,map01100,map01120	M00122	R04148,R05224,R05815	RC00010,RC00033,RC00063,RC01301	ko00000,ko00001,ko00002,ko01000			iSDY_1059.SDY_2242,iSF_1195.SF2059,iSFxv_1172.SFxv_2293,iS_1188.S2169	Bacteria	1MVAM@1224,1RNPV@1236,3XNPP@561,COG2038@1,COG2038@2	NA|NA|NA	F	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)
C1_01186	155864.EDL933_3061	1.9e-175	621.7	Escherichia	erfK	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008234,GO:0008236,GO:0008238,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016746,GO:0016755,GO:0016787,GO:0016807,GO:0017171,GO:0018104,GO:0019538,GO:0030203,GO:0034645,GO:0042546,GO:0043164,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0070004,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071972,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576		ko:K16291,ko:K19234,ko:K19235,ko:K19236	ko01503,map01503				ko00000,ko00001,ko01002,ko01011				Bacteria	1P95A@1224,1RME2@1236,3XMNG@561,COG1376@1,COG1376@2	NA|NA|NA	M	Responsible, at least in part, for anchoring of the major outer membrane lipoprotein (Lpp, also known as the Braun lipoprotein) to the peptidoglycan via a meso-diaminopimelyl-L- Lys- bond on the terminal residue of Lpp
C1_01188	155864.EDL933_3059	1.3e-160	572.4	Escherichia	nac	GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141		ko:K19338					ko00000,ko03000				Bacteria	1MXR1@1224,1RPF3@1236,3XM4K@561,COG0583@1,COG0583@2	NA|NA|NA	K	Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation. Negative regulator of its own expression (By similarity)
C1_01189	316407.1736649	5.5e-175	620.2	Escherichia	cbl	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006792,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0045883,GO:0048518,GO:0050789,GO:0050896,GO:0065007,GO:0097159,GO:1901363		ko:K13634,ko:K13635					ko00000,ko03000				Bacteria	1MU8N@1224,1RN7T@1236,3XM98@561,COG0583@1,COG0583@2	NA|NA|NA	K	Transcriptional regulator
C1_01191	316407.85675181	5.3e-270	936.4	Escherichia	yeeO	GO:0000302,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0006857,GO:0006862,GO:0006950,GO:0006979,GO:0008150,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015215,GO:0015230,GO:0015238,GO:0015605,GO:0015711,GO:0015748,GO:0015833,GO:0015893,GO:0015931,GO:0015932,GO:0016020,GO:0022857,GO:0033554,GO:0034220,GO:0034599,GO:0034614,GO:0035350,GO:0035442,GO:0035672,GO:0035673,GO:0042221,GO:0042493,GO:0042886,GO:0042887,GO:0042891,GO:0042895,GO:0042938,GO:0044464,GO:0044610,GO:0046677,GO:0050896,GO:0051179,GO:0051181,GO:0051182,GO:0051184,GO:0051185,GO:0051234,GO:0051716,GO:0055085,GO:0070887,GO:0071702,GO:0071705,GO:0071916,GO:0071944,GO:0098656,GO:1901264,GO:1901505,GO:1901679,GO:1901700,GO:1901701,GO:1904680		ko:K03327					ko00000,ko02000	2.A.66.1			Bacteria	1MVRV@1224,1RNQ7@1236,3XMYX@561,COG0534@1,COG0534@2	NA|NA|NA	U	A transporter able to export peptides and flavins. When overexpressed allows cells deleted for multiple peptidases (pepA, pepB, pepD and pepN) to grow in the presence of dipeptides Ala-Gln or Gly-Tyr which otherwise inhibit growth. Cells overexpressing this protein have decreased intracellular levels of Ala-Gln dipeptide, and in a system that produces the Ala-Gln dipeptide, overproduction of this protein increases its export. When overexpressed increases secretion of FMN and FAD but not riboflavin
C1_01193	199310.c2445	1.9e-127	461.8	Escherichia	yeeN	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Bacteria	1MW3X@1224,1RP5N@1236,3XQQV@561,COG0217@1,COG0217@2	NA|NA|NA	K	transcriptional regulatory protein YeeN
C1_01194	155864.EDL933_3052	4e-286	989.9	Escherichia	amn	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008714,GO:0016787,GO:0016798,GO:0016799,GO:0044424,GO:0044444,GO:0044464	3.2.2.4	ko:K01241	ko00230,map00230		R00182	RC00063,RC00318	ko00000,ko00001,ko01000			iECABU_c1320.ECABU_c22520,iECOK1_1307.ECOK1_2159,iECP_1309.ECP_1955,iETEC_1333.ETEC_2095,iNRG857_1313.NRG857_09950,iUMN146_1321.UM146_07225,ic_1306.c2444	Bacteria	1MUMQ@1224,1RNZ4@1236,3XP6V@561,COG0775@1,COG0775@2	NA|NA|NA	F	Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations
C1_01195	481805.EcolC_1662	1.3e-246	858.6	Escherichia	shiA	GO:0000271,GO:0003674,GO:0003824,GO:0005215,GO:0005342,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0006810,GO:0006811,GO:0006820,GO:0008028,GO:0008150,GO:0008152,GO:0008509,GO:0008514,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0015075,GO:0015318,GO:0015530,GO:0015711,GO:0015718,GO:0015733,GO:0015849,GO:0015850,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0022857,GO:0033692,GO:0034220,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704,GO:0071944,GO:0098656,GO:1901135,GO:1901137,GO:1901576,GO:1901618,GO:1903509,GO:1903825,GO:1905039		ko:K03761,ko:K03762,ko:K08172,ko:K08173					ko00000,ko02000	2.A.1.6,2.A.1.6.2,2.A.1.6.4,2.A.1.6.6		e_coli_core.b2587,iAF1260.b2587,iAPECO1_1312.APECO1_1067,iB21_1397.B21_02445,iBWG_1329.BWG_2351,iEC55989_1330.EC55989_2218,iEC55989_1330.EC55989_2877,iECBD_1354.ECBD_1093,iECB_1328.ECB_02481,iECDH10B_1368.ECDH10B_2755,iECDH1ME8569_1439.ECDH1ME8569_2514,iECD_1391.ECD_02481,iECIAI1_1343.ECIAI1_2705,iECIAI39_1322.ECIAI39_2795,iECNA114_1301.ECNA114_2055,iECO103_1326.ECO103_3166,iECO111_1330.ECO111_3313,iECO26_1355.ECO26_3634,iECS88_1305.ECS88_2049,iECW_1372.ECW_m2816,iEKO11_1354.EKO11_1146,iETEC_1333.ETEC_2800,iEcDH1_1363.EcDH1_1081,iEcE24377_1341.EcE24377A_2873,iEcolC_1368.EcolC_1090,iJO1366.b2587,iJR904.b2587,iLF82_1304.LF82_2131,iNRG857_1313.NRG857_09945,iSBO_1134.SBO_2619,iSDY_1059.SDY_2830,iSF_1195.SF2649,iSFxv_1172.SFxv_2906,iSSON_1240.SSON_4052,iS_1188.S2822,iUMNK88_1353.UMNK88_3239,iUTI89_1310.UTI89_C4705,iWFL_1372.ECW_m2816,iY75_1357.Y75_RS13520,ic_1306.c5116	Bacteria	1MU46@1224,1RMF0@1236,3XNBS@561,COG0477@1,COG0477@2	NA|NA|NA	P	Shikimate transporter
C1_01196	481805.EcolC_1663	1.8e-190	671.8	Escherichia	rfaF												Bacteria	1R66F@1224,1S0J4@1236,3XQRZ@561,COG0859@1,COG0859@2	NA|NA|NA	M	Glycosyltransferase family 9 (heptosyltransferase)
C1_01197	316407.85675179	0.0	4367.0	Escherichia	lppY	GO:0005575,GO:0005623,GO:0007155,GO:0008150,GO:0009279,GO:0009405,GO:0009987,GO:0016020,GO:0019867,GO:0022610,GO:0030260,GO:0030312,GO:0030313,GO:0031589,GO:0031975,GO:0042710,GO:0043708,GO:0044403,GO:0044409,GO:0044419,GO:0044462,GO:0044464,GO:0044764,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0071944,GO:0090605		ko:K13735	ko05100,map05100				ko00000,ko00001				Bacteria	1MX9S@1224,1RPK7@1236,3XN7T@561,COG1388@1,COG1388@2,COG1470@1,COG1470@2	NA|NA|NA	M	cell adhesion
C1_01200	481805.EcolC_1670	7.1e-152	543.1	Escherichia	mtfA	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006508,GO:0006807,GO:0008134,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009889,GO:0010468,GO:0010556,GO:0016787,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031326,GO:0043170,GO:0043433,GO:0044092,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0048519,GO:0050789,GO:0050794,GO:0051090,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0065009,GO:0070011,GO:0071704,GO:0080090,GO:0140096,GO:1901564,GO:1903506,GO:2000112,GO:2001141		ko:K09933					ko00000,ko01002				Bacteria	1RAHF@1224,1RZQU@1236,3XMFJ@561,COG3228@1,COG3228@2	NA|NA|NA	S	Involved in the regulation of ptsG expression by binding and inactivating Mlc
C1_01202	316407.85675177	1.5e-97	362.1	Escherichia	yodB	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0020037,GO:0044464,GO:0046906,GO:0048037,GO:0071944,GO:0097159,GO:1901363		ko:K12262					ko00000				Bacteria	1RBP8@1224,1S563@1236,3XRMF@561,COG3038@1,COG3038@2	NA|NA|NA	C	respiratory electron transport chain
C1_01203	481805.EcolC_1672	6.7e-127	459.9	Escherichia	adcA	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0007154,GO:0008150,GO:0008270,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010035,GO:0010038,GO:0030288,GO:0030313,GO:0031667,GO:0031668,GO:0031669,GO:0031975,GO:0033554,GO:0034224,GO:0042221,GO:0042594,GO:0042597,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046686,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071496,GO:0120127		ko:K09815	ko02010,map02010	M00242			ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5			Bacteria	1MXFK@1224,1RPWU@1236,3XN2U@561,COG3443@1,COG3443@2	NA|NA|NA	S	May function as a periplasmic zinc chaperone or mediate direct transport of zinc from the periplasm to the cytoplasm under zinc-limited conditions. Binds zinc with high affinity, and can also bind cadmium, mercury or nickel. Preferentially binds Zn(2 ) over Cd(2 ). Contains one high affinity metal binding site, and can bind additional metal ions at other sites
C1_01204	316407.85675175	2.3e-113	414.8	Escherichia	msrQ	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010181,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0019538,GO:0020037,GO:0030091,GO:0031224,GO:0031226,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0050662,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564		ko:K17247					ko00000				Bacteria	1RDUP@1224,1RS9K@1236,3XMFR@561,COG2717@1,COG2717@2	NA|NA|NA	C	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C1_01205	155864.EDL933_2980	1.8e-186	658.3	Escherichia	msrP	GO:0000302,GO:0001101,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0016491,GO:0016667,GO:0016672,GO:0016675,GO:0019538,GO:0030091,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0043170,GO:0043546,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0048037,GO:0050662,GO:0050896,GO:0055114,GO:0071704,GO:0097159,GO:1901363,GO:1901530,GO:1901564,GO:1901700		ko:K07147					ko00000,ko01000				Bacteria	1MUW0@1224,1RQ2J@1236,3XN0Z@561,COG2041@1,COG2041@2	NA|NA|NA	C	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C1_01206	198214.SF2017	2.4e-71	274.6	Gammaproteobacteria	hiuH	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006144,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0033971,GO:0034641,GO:0042802,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:1901360,GO:1901564	3.5.2.17,4.1.1.97	ko:K07127,ko:K13485	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R06601,R06604	RC01551,RC03393	ko00000,ko00001,ko00002,ko01000,ko02000	9.B.35.1.2,9.B.35.2			Bacteria	1RH84@1224,1S6D3@1236,COG2351@1,COG2351@2	NA|NA|NA	S	Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily
C1_01207	155864.EDL933_2978	3.9e-142	510.8	Escherichia													Bacteria	1MU67@1224,1RNWH@1236,3XPAK@561,COG0745@1,COG0745@2	NA|NA|NA	K	transcriptional regulatory protein YedW
C1_01208	316407.1736637	1e-246	859.0	Escherichia													Bacteria	1MW8M@1224,1RNDA@1236,3XMWP@561,COG0642@1,COG2205@2	NA|NA|NA	T	PhoQ Sensor
C1_01209	316407.85675171	2.3e-164	584.7	Escherichia	hchA	GO:0003674,GO:0003700,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006089,GO:0006139,GO:0006259,GO:0006281,GO:0006355,GO:0006457,GO:0006464,GO:0006517,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009100,GO:0009266,GO:0009268,GO:0009314,GO:0009408,GO:0009411,GO:0009416,GO:0009438,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010447,GO:0010468,GO:0010556,GO:0016053,GO:0016070,GO:0016829,GO:0016835,GO:0016836,GO:0019172,GO:0019219,GO:0019222,GO:0019243,GO:0019249,GO:0019538,GO:0019752,GO:0022613,GO:0030091,GO:0031323,GO:0031326,GO:0032787,GO:0033554,GO:0034599,GO:0034641,GO:0036211,GO:0036524,GO:0036525,GO:0042026,GO:0042180,GO:0042182,GO:0042221,GO:0042245,GO:0042254,GO:0042802,GO:0043170,GO:0043412,GO:0043436,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0046394,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051595,GO:0051596,GO:0051716,GO:0060255,GO:0061727,GO:0065007,GO:0070887,GO:0071704,GO:0071840,GO:0072330,GO:0080090,GO:0090304,GO:0140096,GO:0140110,GO:1901135,GO:1901360,GO:1901564,GO:1901575,GO:1901576,GO:1901615,GO:1901617,GO:1901654,GO:1901700,GO:1903506,GO:2000112,GO:2001141	3.5.1.124,4.2.1.130,5.3.1.6	ko:K01807,ko:K03152,ko:K05520,ko:K05523	ko00030,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00620,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056,R09796	RC00434,RC02658	ko00000,ko00001,ko00002,ko01000,ko01002				Bacteria	1R41H@1224,1RR9T@1236,3XNHU@561,COG0693@1,COG0693@2	NA|NA|NA	J	Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of Schiff bases and advanced glycation endproducts (AGE). Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair. Plays an important role in protecting cells from carbonyl stress
C1_01210	502347.ESCAB7627_3518	7.3e-193	679.9	Escherichia	ompS1												Bacteria	1MVRY@1224,1RNBS@1236,3XN4M@561,COG3203@1,COG3203@2	NA|NA|NA	M	Outer membrane protein N
C1_01212	316407.85675170	3.7e-53	213.8	Escherichia	yedR	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1N08R@1224,1SA7X@1236,2DZQZ@1,32VGN@2,3XPU8@561	NA|NA|NA		
C1_01213	362663.ECP_1895	7.2e-124	449.9	Escherichia	yedJ			ko:K06950					ko00000				Bacteria	1RB2W@1224,1RR38@1236,3XM7Y@561,COG1418@1,COG1418@2	NA|NA|NA	S	Metal dependent phosphohydrolases with conserved 'HD' motif.
C1_01214	155864.EDL933_2969	5.7e-277	959.5	Escherichia	dcm	GO:0003674,GO:0003824,GO:0003886,GO:0006139,GO:0006259,GO:0006304,GO:0006305,GO:0006306,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009008,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0032776,GO:0034641,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044728,GO:0046483,GO:0071704,GO:0090116,GO:0090304,GO:0140097,GO:1901360	2.1.1.37	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036				Bacteria	1MV9H@1224,1RPM4@1236,3XPAF@561,COG0270@1,COG0270@2	NA|NA|NA	L	This methylase recognizes the double-stranded sequence CCWGG, causes specific methylation on C-2 on both strands
C1_01215	481805.EcolC_1683	1.8e-86	325.1	Escherichia	vsr	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0043170,GO:0043765,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363		ko:K07458					ko00000,ko01000,ko03400			iB21_1397.ECBD_1686,iECD_1391.ECBD_1686	Bacteria	1RH1C@1224,1S2V3@1236,3XME9@561,COG3727@1,COG3727@2	NA|NA|NA	L	May nick specific sequences that contain T G mispairs resulting from m5C-deamination
C1_01216	155864.EDL933_2967	3.8e-157	560.8	Escherichia	yedA	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944											Bacteria	1MXX1@1224,1RPRZ@1236,3XMGK@561,COG0697@1,COG0697@2	NA|NA|NA	EG	inner membrane transporter YedA
C1_01217	481805.EcolC_1685	2.1e-155	555.1	Escherichia	yedI	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K09781					ko00000				Bacteria	1MVYU@1224,1RMUZ@1236,3XMZD@561,COG2354@1,COG2354@2	NA|NA|NA	S	Protein of unknown function (DUF808)
C1_01218	481805.EcolC_1686	2.1e-27	127.5	Escherichia	yodC												Bacteria	1N81T@1224,1SD0R@1236,3XQ38@561,COG5475@1,COG5475@2	NA|NA|NA	S	Uncharacterized small protein (DUF2158)
C1_01219	316407.1736626	0.0	1116.3	Escherichia	yedQ	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0032879,GO:0040012,GO:0040013,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051270,GO:0051271,GO:0052621,GO:0065007,GO:0071944,GO:1902021,GO:1902201,GO:2000145,GO:2000146	2.7.7.65	ko:K21085	ko02026,map02026				ko00000,ko00001,ko01000			iLF82_1304.LF82_2957,iSbBS512_1146.SbBS512_E1077	Bacteria	1MZV7@1224,1RSJI@1236,3XN3P@561,COG2199@1,COG3706@2	NA|NA|NA	T	in the regulation of cellulose production
C1_01220	316407.85675168	5.4e-155	553.5	Escherichia	yedP	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050897	2.7.1.31,3.1.3.70	ko:K07026,ko:K15918	ko00051,ko00260,ko00561,ko00630,ko01100,ko01110,ko01130,ko01200,map00051,map00260,map00561,map00630,map01100,map01110,map01130,map01200	M00532	R01514,R05790	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000				Bacteria	1NFV5@1224,1RR9R@1236,3XM3H@561,COG3769@1,COG3769@2	NA|NA|NA	S	glycoside biosynthetic process
C1_01221	155864.EDL933_2961	4.2e-33	146.7	Escherichia	yodD	GO:0000302,GO:0006950,GO:0006979,GO:0008150,GO:0009268,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0010447,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042710,GO:0044010,GO:0044011,GO:0044764,GO:0046677,GO:0050896,GO:0051703,GO:0051704,GO:0051716,GO:0070301,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071468,GO:0090605,GO:0090609,GO:0097237,GO:0104004,GO:1901700,GO:1901701											Bacteria	1NC7W@1224,1SBI7@1236,2E0QC@1,32W92@2,3XQ40@561	NA|NA|NA	S	cellular response to acidic pH
C1_01222	1440052.EAKF1_ch4087	1.5e-28	131.3	Escherichia	dsrB												Bacteria	1N7NE@1224,1SD23@1236,2E52Z@1,32ZW5@2,3XQ2F@561	NA|NA|NA	S	Belongs to the DsrB family
C1_01223	198214.SF1996	1.2e-109	402.5	Gammaproteobacteria	rcsA	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576		ko:K07688,ko:K07781	ko02020,ko02024,ko02026,map02020,map02024,map02026				ko00000,ko00001,ko02022,ko03000				Bacteria	1MWHX@1224,1RRK0@1236,COG2197@1,COG2197@2	NA|NA|NA	K	Component of the Rcs signaling system, which controls transcription of numerous genes. Binds to DNA to regulate expression of genes
C1_01224	155864.EDL933_2958	4e-131	474.2	Escherichia	fliR	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02421	ko02040,map02040				ko00000,ko00001,ko02035,ko02044	3.A.6.2			Bacteria	1NIF4@1224,1RMYW@1236,3XN5S@561,COG1684@1,COG1684@2	NA|NA|NA	N	Role in flagellar biosynthesis
C1_01225	155864.EDL933_2957	9.7e-37	159.1	Escherichia	fliQ			ko:K02420	ko02040,map02040				ko00000,ko00001,ko02035,ko02044	3.A.6.2			Bacteria	1N73W@1224,1SCBG@1236,3XPW6@561,COG1987@1,COG1987@2	NA|NA|NA	N	Flagellar biosynthetic protein FliQ
C1_01226	155864.EDL933_2956	2.1e-126	458.4	Escherichia	fliP	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02419,ko:K03226	ko02040,ko03070,map02040,map03070	M00332,M00542,M00660			ko00000,ko00001,ko00002,ko02035,ko02044	3.A.6.1,3.A.6.2,3.A.6.3			Bacteria	1MVBU@1224,1RMYH@1236,3XM6F@561,COG1338@1,COG1338@2	NA|NA|NA	N	Plays a role in the flagellum-specific transport system
C1_01227	155864.EDL933_2955	3.7e-55	220.7	Escherichia	fliO			ko:K02418	ko02040,map02040				ko00000,ko00001,ko02035,ko02044	3.A.6.2			Bacteria	1N79Z@1224,1SCKP@1236,3XPVU@561,COG3190@1,COG3190@2	NA|NA|NA	N	bacterial-type flagellum organization
C1_01228	155864.EDL933_2954	4e-66	257.3	Escherichia	fliN	GO:0005575,GO:0005623,GO:0005886,GO:0009288,GO:0009425,GO:0016020,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0071944		ko:K02417	ko02030,ko02040,map02030,map02040				ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3			Bacteria	1RGWT@1224,1S5YE@1236,3XPJF@561,COG1886@1,COG1886@2	NA|NA|NA	N	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C1_01229	155864.EDL933_2953	3.2e-189	667.5	Escherichia	fliM	GO:0005575,GO:0005623,GO:0005886,GO:0006935,GO:0008150,GO:0009288,GO:0009425,GO:0009605,GO:0016020,GO:0040011,GO:0042221,GO:0042330,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0050896,GO:0050918,GO:0071944		ko:K02416	ko02030,ko02040,map02030,map02040				ko00000,ko00001,ko02035				Bacteria	1MX01@1224,1RQ8M@1236,3XNNG@561,COG1868@1,COG1868@2	NA|NA|NA	N	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C1_01230	155864.EDL933_2952	1.6e-79	302.0	Escherichia	fliL	GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009425,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588		ko:K02415					ko00000,ko02035				Bacteria	1RARK@1224,1S2F1@1236,3XMI3@561,COG1580@1,COG1580@2	NA|NA|NA	N	Controls the rotational direction of flagella during chemotaxis
C1_01231	199310.c2360	4.6e-189	667.2	Escherichia	fliK	GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009424,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588		ko:K02414	ko02040,map02040				ko00000,ko00001,ko02035				Bacteria	1N7XT@1224,1SCA6@1236,3XNRK@561,COG3144@1,COG3144@2	NA|NA|NA	N	Flagellar hook-length control protein
C1_01232	155864.EDL933_2950	1.8e-72	278.5	Escherichia	fliJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02413	ko02040,map02040				ko00000,ko00001,ko02035				Bacteria	1RHFM@1224,1S76M@1236,3XPK5@561,COG2882@1,COG2882@2	NA|NA|NA	N	Flagellar protein that affects chemotactic events
C1_01233	155864.EDL933_2949	2.9e-254	884.0	Escherichia	fliI	GO:0003674,GO:0005488,GO:0005515,GO:0042802	3.6.3.14	ko:K02412	ko02040,map02040				ko00000,ko00001,ko01000,ko02035,ko02044	3.A.6.2,3.A.6.3			Bacteria	1MUH6@1224,1RM9W@1236,3XN8K@561,COG1157@1,COG1157@2	NA|NA|NA	NU	catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum. May be involved in a specialized protein export pathway that proceeds without signal peptide cleavage
C1_01234	481805.EcolC_1702	1.4e-100	372.5	Escherichia	fliH	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K02411	ko02040,map02040				ko00000,ko00001,ko02035,ko02044	3.A.6.2			Bacteria	1NMQE@1224,1RR8H@1236,3XMIR@561,COG1317@1,COG1317@2	NA|NA|NA	N	Flagellar assembly protein fliH
C1_01235	155864.EDL933_2947	1.3e-174	619.0	Escherichia	fliG	GO:0001539,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006928,GO:0006996,GO:0008150,GO:0009288,GO:0009425,GO:0009987,GO:0016020,GO:0016043,GO:0022607,GO:0030030,GO:0030031,GO:0040011,GO:0042802,GO:0042803,GO:0042995,GO:0043226,GO:0043228,GO:0044085,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0044780,GO:0044781,GO:0046982,GO:0046983,GO:0048870,GO:0051179,GO:0051674,GO:0070925,GO:0071840,GO:0071944,GO:0071973,GO:0071978,GO:0097588		ko:K02410	ko02030,ko02040,map02030,map02040				ko00000,ko00001,ko02035				Bacteria	1MV9X@1224,1RM9B@1236,3XMFG@561,COG1536@1,COG1536@2	NA|NA|NA	N	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C1_01236	316407.1736604	8.6e-301	1038.9	Escherichia	fliF			ko:K02409	ko02040,map02040				ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3			Bacteria	1MUQR@1224,1RN6T@1236,3XNC5@561,COG1766@1,COG1766@2	NA|NA|NA	N	The M ring may be actively involved in energy transduction
C1_01237	155864.EDL933_2944	6e-46	189.9	Escherichia	fliE			ko:K02408	ko02040,map02040				ko00000,ko00001,ko02035				Bacteria	1N6RZ@1224,1SD52@1236,3XPVX@561,COG1677@1,COG1677@2	NA|NA|NA	N	Flagellar hook-basal body complex protein FliE
C1_01238	155864.EDL933_2943	4.8e-146	524.2	Gammaproteobacteria				ko:K07126,ko:K09973					ko00000				Bacteria	1NF73@1224,1RXVA@1236,COG4886@1,COG4886@2	NA|NA|NA	S	COG4886 Leucine-rich repeat (LRR) protein
C1_01239	316407.85675164	2.2e-87	328.2	Gammaproteobacteria	yedL	GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031248,GO:0031365,GO:0032991,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564,GO:1902493,GO:1902494,GO:1990234		ko:K03829					ko00000,ko01000				Bacteria	1QUHE@1224,1T1Z5@1236,COG0454@1,COG0454@2	NA|NA|NA	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
C1_01240	155864.EDL933_2939	2.4e-129	468.0	Escherichia	yedK												Bacteria	1RER4@1224,1RSBH@1236,3XMZS@561,COG2135@1,COG2135@2	NA|NA|NA	E	Belongs to the SOS response-associated peptidase family
C1_01241	1080067.BAZH01000024_gene3535	1e-37	162.2	Citrobacter	yedF	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0019725,GO:0033554,GO:0042592,GO:0048878,GO:0050896,GO:0051716,GO:0055082,GO:0065007,GO:0065008											Bacteria	1N0EX@1224,1S9V5@1236,3WYUJ@544,COG0425@1,COG0425@2	NA|NA|NA	O	Sulfurtransferase TusA
C1_01242	316407.1736597	1.2e-235	822.0	Escherichia	yedE	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K07112					ko00000				Bacteria	1PF9B@1224,1RNE8@1236,3XN3Y@561,COG2391@1,COG2391@2	NA|NA|NA	S	Sulphur transport
C1_01243	155864.EDL933_2936	2.2e-72	278.1	Escherichia	yedD												Bacteria	1RDMY@1224,1S41Z@1236,2C08M@1,2ZQUD@2,3XPN0@561	NA|NA|NA	M	YedD-like protein
C1_01244	199310.c2342	9.8e-304	1048.5	Escherichia	amyA	GO:0003674,GO:0003824,GO:0004553,GO:0004556,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016160,GO:0016787,GO:0016798,GO:0044424,GO:0044464	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973		R02108,R02112,R11262		ko00000,ko00001,ko01000		GH13	iECH74115_1262.ECH74115_2702,iECSP_1301.ECSP_2532,iECs_1301.ECs2666,iG2583_1286.G2583_2378,iSF_1195.SF1970	Bacteria	1MX9V@1224,1RP7Z@1236,3XN4K@561,COG0366@1,COG0366@2	NA|NA|NA	G	alpha-amylase activity
C1_01245	155864.EDL933_2934	4.2e-59	233.8	Escherichia	fliT	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588		ko:K02423	ko02040,map02040				ko00000,ko00001,ko02035				Bacteria	1NC88@1224,1SCME@1236,2DNZ7@1,32ZV7@2,3XPTB@561	NA|NA|NA	K	it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus
C1_01246	199310.c2340	2.4e-63	248.1	Escherichia	fliS	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588		ko:K02422	ko02040,map02040				ko00000,ko00001,ko02035				Bacteria	1MZ3G@1224,1S8TQ@1236,3XPKU@561,COG1516@1,COG1516@2	NA|NA|NA	N	bacterial-type flagellum assembly
C1_01247	481805.EcolC_1715	6.1e-223	780.0	Escherichia	fliD	GO:0001539,GO:0005575,GO:0005576,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009420,GO:0009421,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588		ko:K02407	ko02040,map02040				ko00000,ko00001,ko02035				Bacteria	1MUVP@1224,1RS2S@1236,3XMUS@561,COG1345@1,COG1345@2	NA|NA|NA	N	morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C1_01248	517433.PanABDRAFT_3960	2.2e-198	698.7	Pantoea	fliC	GO:0005575,GO:0005576,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464		ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134				ko00000,ko00001,ko02035				Bacteria	1MV1N@1224,1RN0Y@1236,3VZRA@53335,COG1344@1,COG1344@2	NA|NA|NA	N	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C1_01249	199310.c2337	2.7e-126	458.0	Escherichia	fliA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111				ko00000,ko00001,ko02035,ko03021				Bacteria	1MWEU@1224,1RMKJ@1236,3XMN3@561,COG1191@1,COG1191@2	NA|NA|NA	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes
C1_01250	155864.EDL933_2928	8.5e-104	382.9	Escherichia	fliZ	GO:0000988,GO:0000989,GO:0001047,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0008150,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032879,GO:0040012,GO:0044212,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0051270,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902021,GO:1903506,GO:2000145,GO:2001141		ko:K02425	ko02026,map02026				ko00000,ko00001,ko02035			iB21_1397.fliZ,iECD_1391.fliZ	Bacteria	1P3KM@1224,1RRB7@1236,2DBMG@1,2Z9YQ@2,3XMC2@561	NA|NA|NA	K	During the post-exponential growth phase transiently interferes with RpoS (sigma S) activity without affecting expression of RpoS itself. It is probably not an anti-sigma factor as its overexpression is detrimental in rapidly growing cells where there is almost no sigma S factor. There is a strong overlap between Crl-activated genes and FliZ-down-regulated genes. FliZ acts as a timing device for expression of the genes for the adhesive curli fimbriae by indirectly decreasing expression of the curli regulator CsgD
C1_01251	199310.c2335	3.9e-156	557.4	Escherichia	fliY	GO:0000099,GO:0000101,GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005488,GO:0005575,GO:0005623,GO:0006791,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015179,GO:0015184,GO:0015318,GO:0015711,GO:0015804,GO:0015807,GO:0015811,GO:0015849,GO:0016597,GO:0022857,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0034220,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0043177,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0072337,GO:0072348,GO:0072349,GO:0098656,GO:1901682,GO:1902475,GO:1903825,GO:1905039		ko:K02424	ko02010,map02010	M00234			ko00000,ko00001,ko00002,ko02000,ko02035	3.A.1.3.10,3.A.1.3.14			Bacteria	1MXME@1224,1RPQ4@1236,3XRF1@561,COG0834@1,COG0834@2	NA|NA|NA	ET	Ligated ion channel L-glutamate- and glycine-binding site
C1_01252	316407.85675161	2.8e-182	644.4	Escherichia	dcyD	GO:0000096,GO:0000098,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006790,GO:0006791,GO:0006807,GO:0006950,GO:0007154,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009093,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010438,GO:0016054,GO:0016829,GO:0016846,GO:0016848,GO:0019148,GO:0019149,GO:0019447,GO:0019478,GO:0019752,GO:0019842,GO:0030170,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036094,GO:0042594,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046416,GO:0046438,GO:0048037,GO:0050662,GO:0050896,GO:0051716,GO:0070279,GO:0071496,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	4.4.1.15	ko:K05396	ko00270,map00270		R01874	RC00382	ko00000,ko00001,ko01000			iSFV_1184.SFV_1963,iSF_1195.SF1962,iSFxv_1172.SFxv_2191,iS_1188.S2058	Bacteria	1MVYF@1224,1RMYP@1236,3XND5@561,COG2515@1,COG2515@2	NA|NA|NA	E	Catalyzes the alpha,beta-elimination reaction of D- cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine
C1_01253	198214.SF1961	1.5e-115	422.2	Gammaproteobacteria	yecS	GO:0000099,GO:0000101,GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006791,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015179,GO:0015184,GO:0015318,GO:0015711,GO:0015804,GO:0015807,GO:0015811,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0072348,GO:0072349,GO:0098656,GO:1901682,GO:1902475,GO:1903825,GO:1905039		ko:K10009	ko02010,map02010	M00234			ko00000,ko00001,ko00002,ko02000	3.A.1.3.10,3.A.1.3.14		iJN746.PP_0226	Bacteria	1QN80@1224,1RR3B@1236,COG0765@1,COG0765@2	NA|NA|NA	P	amino acid ABC transporter
C1_01254	316407.1736576	2.3e-131	474.9	Escherichia	yecC	GO:0000099,GO:0000101,GO:0000166,GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008144,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015179,GO:0015184,GO:0015318,GO:0015711,GO:0015804,GO:0015807,GO:0015811,GO:0015849,GO:0016020,GO:0017076,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034220,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0072348,GO:0072349,GO:0097159,GO:0097367,GO:0098656,GO:1901265,GO:1901363,GO:1901682,GO:1902475,GO:1903825,GO:1905039	3.6.3.21	ko:K02028,ko:K10010	ko02010,map02010	M00234,M00236			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3,3.A.1.3.10,3.A.1.3.14			Bacteria	1MU9Q@1224,1RMX1@1236,3XMSB@561,COG1126@1,COG1126@2	NA|NA|NA	P	Part of the ABC transporter complex FliY-YecC-YecS involved in L-cystine transport. The system can probably also transport L-cysteine, and it mediates accumulation of the toxic compounds L-selenaproline (SCA) and L-selenocystine (SeCys). Probably responsible for energy coupling to the transport system
C1_01255	155864.EDL933_2923	2.3e-133	481.5	Escherichia	sdiA	GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010564,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032465,GO:0032467,GO:0043254,GO:0044087,GO:0044089,GO:0045787,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051302,GO:0051726,GO:0051781,GO:0060255,GO:0065007,GO:0080090,GO:0090068,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2000142,GO:2000144,GO:2001141		ko:K07782,ko:K15852,ko:K19666	ko02020,ko02024,ko02026,map02020,map02024,map02026				ko00000,ko00001,ko03000				Bacteria	1R4TP@1224,1RR98@1236,3XPEZ@561,COG2197@1,COG2197@2	NA|NA|NA	K	Activates cell division by specifically increasing transcription from one of the two promoters that lie immediately upstream of the ftsQAZ gene cluster. Activates ydiV expression in response to extracellular autoinducer AI-1 (Vibrio fischeri autoinducer oxoC6)
C1_01256	1440052.EAKF1_ch4120c	1.1e-30	138.7	Escherichia	yecF												Bacteria	1N71V@1224,1SCS7@1236,2E5U3@1,330IE@2,3XPZQ@561	NA|NA|NA	S	Protein of unknown function (DUF2594)
C1_01257	155864.EDL933_2919	2.2e-114	418.3	Escherichia	uvrY	GO:0000156,GO:0000160,GO:0003674,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0023052,GO:0035556,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007		ko:K02282,ko:K07686,ko:K07687,ko:K07688,ko:K07689,ko:K07690,ko:K20264	ko02020,ko02024,ko02025,ko02026,ko05111,ko05133,map02020,map02024,map02025,map02026,map05111,map05133	M00473,M00474,M00475,M00477,M00697,M00818			ko00000,ko00001,ko00002,ko01504,ko02022,ko02035,ko02044				Bacteria	1MWGM@1224,1RQ1J@1236,3XN63@561,COG2197@1,COG2197@2	NA|NA|NA	K	Member of the two-component regulatory system UvrY BarA involved in the regulation of carbon metabolism via the CsrA CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the effects of CsrA on csrB RNA by BarA-dependent and BarA-independent mechanisms
C1_01258	155864.EDL933_2918	0.0	1204.5	Escherichia	uvrC	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016787,GO:0016788,GO:0030312,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1902494,GO:1905347,GO:1905348,GO:1990391		ko:K03703	ko03420,map03420				ko00000,ko00001,ko03400				Bacteria	1MV38@1224,1RNGV@1236,3XNGD@561,COG0322@1,COG0322@2	NA|NA|NA	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
C1_01259	1440052.EAKF1_ch4123	3.5e-97	360.9	Escherichia	pgsA	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0031224,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100		R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000			iAF1260.b1912,iAPECO1_1312.APECO1_954,iB21_1397.B21_01866,iBWG_1329.BWG_1721,iE2348C_1286.E2348C_2030,iEC042_1314.EC042_2073,iEC55989_1330.EC55989_2132,iECABU_c1320.ECABU_c21710,iECBD_1354.ECBD_1731,iECB_1328.ECB_01877,iECDH10B_1368.ECDH10B_2053,iECDH1ME8569_1439.ECDH1ME8569_1852,iECD_1391.ECD_01877,iECED1_1282.ECED1_2177,iECH74115_1262.ECH74115_2684,iECIAI1_1343.ECIAI1_1996,iECIAI39_1322.ECIAI39_1143,iECNA114_1301.ECNA114_2003,iECO103_1326.ECO103_2168,iECO111_1330.ECO111_2492,iECO26_1355.ECO26_2804,iECOK1_1307.ECOK1_2029,iECP_1309.ECP_1852,iECS88_1305.ECS88_1966,iECSF_1327.ECSF_1764,iECSP_1301.ECSP_2516,iECUMN_1333.ECUMN_2204,iECs_1301.ECs2650,iETEC_1333.ETEC_2020,iEcDH1_1363.EcDH1_1734,iEcE24377_1341.EcE24377A_2145,iEcHS_1320.EcHS_A2010,iEcSMS35_1347.EcSMS35_1271,iEcolC_1368.EcolC_1727,iG2583_1286.G2583_2363,iJO1366.b1912,iJR904.b1912,iLF82_1304.LF82_1635,iNRG857_1313.NRG857_09550,iSDY_1059.SDY_1106,iSSON_1240.SSON_1206,iSbBS512_1146.SbBS512_E1039,iUMN146_1321.UM146_07620,iUMNK88_1353.UMNK88_2386,iUTI89_1310.UTI89_C2113,iY75_1357.Y75_RS10025,iYL1228.KPN_02410,iZ_1308.Z3000,ic_1306.c2325	Bacteria	1RCZ7@1224,1S465@1236,3XM7U@561,COG0558@1,COG0558@2	NA|NA|NA	I	This protein catalyzes the committed step to the synthesis of the acidic phospholipids
C1_01263	155864.EDL933_2885	1.1e-126	459.1	Escherichia	yecA			ko:K07039					ko00000				Bacteria	1R4KR@1224,1RRDM@1236,3XMQH@561,COG3012@1,COG3012@2,COG3318@1,COG3318@2	NA|NA|NA	S	Belongs to the UPF0149 family
C1_01264	469008.B21_01864	7.4e-217	759.6	Escherichia	tyrP	GO:0003333,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0015291,GO:0015293,GO:0015711,GO:0015849,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:1903825,GO:1905039		ko:K03834,ko:K03835,ko:K03836,ko:K03837,ko:K03838					ko00000,ko02000	2.A.42.1.1,2.A.42.1.2,2.A.42.1.3,2.A.42.2.1,2.A.42.2.2		iAPECO1_1312.APECO1_3308,iE2348C_1286.E2348C_3406,iEC55989_1330.EC55989_3533,iEC55989_1330.EC55989_3581,iECABU_c1320.ECABU_c35330,iECED1_1282.ECED1_3781,iECIAI1_1343.ECIAI1_3265,iECNA114_1301.ECNA114_4343,iECO103_1326.ECO103_3863,iECO103_1326.ECO103_3910,iECO111_1330.ECO111_3985,iECO26_1355.ECO26_4221,iECO26_1355.ECO26_4267,iECOK1_1307.ECOK1_3543,iECP_1309.ECP_3209,iECSE_1348.ECSE_3400,iECSE_1348.ECSE_3447,iECSF_1327.ECSF_2956,iECUMN_1333.ECUMN_2202,iECW_1372.ECW_m3385,iEKO11_1354.EKO11_0601,iEcE24377_1341.EcE24377A_3643,iLF82_1304.LF82_2232,iNRG857_1313.NRG857_15495,iSBO_1134.SBO_2981,iSDY_1059.SDY_3013,iSFV_1184.SFV_3804,iSFxv_1172.SFxv_4080,iSSON_1240.SSON_3307,iS_1188.S4018,iSbBS512_1146.SbBS512_E3241,iUMN146_1321.UM146_00750,iUTI89_1310.UTI89_C3551,iWFL_1372.ECW_m3385,ic_1306.c3874	Bacteria	1N35H@1224,1RNNC@1236,3XN6H@561,COG0814@1,COG0814@2	NA|NA|NA	E	Tyrosine-specific transport protein
C1_01265	155864.EDL933_2882	3e-37	160.6	Escherichia	yecH												Bacteria	1N09N@1224,1SA8V@1236,2E9BS@1,333JI@2,3XQ13@561	NA|NA|NA	S	Protein of unknown function (DUF2492)
C1_01266	1440052.EAKF1_ch4138c	7e-89	333.2	Escherichia	ftnA	GO:0003674,GO:0003824,GO:0004322,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0008152,GO:0008199,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0016491,GO:0016722,GO:0016724,GO:0019725,GO:0030003,GO:0033554,GO:0042221,GO:0042592,GO:0042802,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071241,GO:0071248,GO:0071281,GO:0097577,GO:0098771	1.16.3.2	ko:K02217,ko:K02255					ko00000,ko01000				Bacteria	1R9ZC@1224,1RYVB@1236,3XPF1@561,COG1528@1,COG1528@2	NA|NA|NA	P	Iron-storage protein
C1_01267	198214.SF1950	1.4e-53	215.3	Gammaproteobacteria	yecR												Bacteria	1N47Q@1224,1SA54@1236,2DX6P@1,32V2W@2	NA|NA|NA	S	YecR-like lipoprotein
C1_01268	199310.c2316	2e-36	157.9	Escherichia	yecJ												Bacteria	1MZGJ@1224,1S9UW@1236,2CJJE@1,32SA5@2,3XPYA@561	NA|NA|NA	S	Protein of unknown function (DUF2766)
C1_01269	155864.EDL933_2875	4.3e-86	323.9	Escherichia	ftnA	GO:0003674,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0008150,GO:0009987,GO:0019725,GO:0030003,GO:0042592,GO:0042802,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0097577,GO:0098771	1.16.3.2	ko:K02217,ko:K02255					ko00000,ko01000				Bacteria	1RDH6@1224,1S4UV@1236,3XPDA@561,COG1528@1,COG1528@2	NA|NA|NA	P	Iron-storage protein
C1_01270	155864.EDL933_2874	1.4e-184	652.1	Escherichia	araF	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015399,GO:0015405,GO:0015407,GO:0015749,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0030246,GO:0030288,GO:0030313,GO:0031975,GO:0034219,GO:0036094,GO:0042597,GO:0042623,GO:0042626,GO:0043211,GO:0043492,GO:0044464,GO:0048029,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702		ko:K10537	ko02010,map02010	M00213			ko00000,ko00001,ko00002,ko02000	3.A.1.2.2		iECIAI39_1322.ECIAI39_1152,iECOK1_1307.ECOK1_2016,iECP_1309.ECP_1842,iECS88_1305.ECS88_1956,iECSE_1348.ECSE_2133,iLF82_1304.LF82_0110,iNRG857_1313.NRG857_09510,iUMN146_1321.UM146_07665	Bacteria	1MVDG@1224,1RMBR@1236,3XNEH@561,COG1879@1,COG1879@2	NA|NA|NA	G	L-arabinose-binding periplasmic protein
C1_01271	199310.c2313	5.5e-286	989.6	Escherichia	araG	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044444,GO:0044464,GO:0071944	3.6.3.17	ko:K10539	ko02010,map02010	M00213			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.2		iSSON_1240.SSON_1218	Bacteria	1MU22@1224,1RSMB@1236,3XMD4@561,COG1129@1,COG1129@2	NA|NA|NA	P	Part of the ABC transporter complex AraFGH involved in arabinose import. Responsible for energy coupling to the transport system
C1_01272	198214.SF1945	1.1e-165	589.3	Gammaproteobacteria	araH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016021,GO:0031224,GO:0044425,GO:0044464,GO:0071944		ko:K10538,ko:K17214	ko02010,map02010	M00213,M00593			ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.2		iUMNK88_1353.UMNK88_2369	Bacteria	1MVN9@1224,1RPYE@1236,COG1172@1,COG1172@2	NA|NA|NA	G	Belongs to the binding-protein-dependent transport system permease family
C1_01273	155864.EDL933_2870	2.2e-148	531.6	Escherichia	otsB	GO:0000287,GO:0003674,GO:0003824,GO:0004805,GO:0005488,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0009058,GO:0009266,GO:0009311,GO:0009312,GO:0009409,GO:0009628,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0033554,GO:0034637,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0046351,GO:0046872,GO:0050896,GO:0051716,GO:0070413,GO:0070415,GO:0070417,GO:0071704,GO:1901576	2.4.1.15,2.4.1.347,3.1.3.12	ko:K00697,ko:K01087,ko:K16055	ko00500,ko01100,map00500,map01100		R02737,R02778	RC00005,RC00017,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003		GT20	iE2348C_1286.E2348C_2018,iECED1_1282.ECED1_2163,iECIAI39_1322.ECIAI39_1155,iECS88_1305.ECS88_1952,iLF82_1304.LF82_1582,iNRG857_1313.NRG857_09495	Bacteria	1RGY2@1224,1RNIQ@1236,3XMM7@561,COG1877@1,COG1877@2	NA|NA|NA	G	Removes the phosphate from trehalose 6-phosphate to produce free trehalose
C1_01274	316407.85675158	3e-278	963.8	Escherichia	otsA	GO:0003674,GO:0003824,GO:0003825,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0006970,GO:0006974,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009266,GO:0009311,GO:0009312,GO:0009409,GO:0009628,GO:0009987,GO:0016051,GO:0016311,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0016788,GO:0016791,GO:0033554,GO:0034637,GO:0035251,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046527,GO:0050896,GO:0051716,GO:0070413,GO:0070415,GO:0070417,GO:0071704,GO:1901576	2.4.1.15,2.4.1.347	ko:K00697	ko00500,ko01100,map00500,map01100		R02737	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003		GT20	iECs_1301.ECs2604,iZ_1308.Z2949	Bacteria	1MUIY@1224,1RNG7@1236,3XPDP@561,COG0380@1,COG0380@2	NA|NA|NA	G	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
C1_01275	155864.EDL933_2868	1.1e-71	275.8	Escherichia	uspC	GO:0003674,GO:0005198,GO:0005488,GO:0005515,GO:0006950,GO:0006970,GO:0007154,GO:0008150,GO:0009267,GO:0009314,GO:0009411,GO:0009416,GO:0009605,GO:0009628,GO:0009651,GO:0009987,GO:0009991,GO:0031667,GO:0031668,GO:0031669,GO:0032947,GO:0033554,GO:0034644,GO:0042594,GO:0050896,GO:0051716,GO:0071214,GO:0071478,GO:0071482,GO:0071496,GO:0104004		ko:K06149,ko:K14064,ko:K14065					ko00000				Bacteria	1N4C6@1224,1S41H@1236,3XPJE@561,COG0589@1,COG0589@2	NA|NA|NA	T	Required for resistance to DNA-damaging agents
C1_01276	199310.c2308	1.2e-55	222.2	Escherichia	flhD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576		ko:K02403	ko02020,ko02024,ko02026,ko02040,map02020,map02024,map02026,map02040				ko00000,ko00001,ko02035				Bacteria	1N25K@1224,1S6JK@1236,2AX91@1,31P80@2,3XPQG@561	NA|NA|NA	K	Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways
C1_01277	155864.EDL933_2866	2.8e-105	387.9	Escherichia	flhC	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051302,GO:0051782,GO:0065007,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576		ko:K02402	ko02020,ko02024,ko02026,ko02040,map02020,map02024,map02026,map02040				ko00000,ko00001,ko02035				Bacteria	1N7I6@1224,1RNUP@1236,2DBG4@1,2Z927@2,3XMRH@561	NA|NA|NA	K	Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways
C1_01278	155864.EDL933_2865	9.4e-153	546.2	Escherichia	motA	GO:0001539,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006928,GO:0008150,GO:0009288,GO:0009425,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044425,GO:0044459,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071944,GO:0071973,GO:0071978,GO:0097588,GO:0120100,GO:0120101		ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040				ko00000,ko00001,ko02000,ko02035	1.A.30.1			Bacteria	1MXK3@1224,1RNTF@1236,3XPC5@561,COG1291@1,COG1291@2	NA|NA|NA	N	transmembrane proton channel. Overexpression of MotA, with or without MotB, restores motility in a yhjH disruption, (a c-di-GMP phosphodiesterase) suggesting there is an interaction (direct or indirect) between the c-di-GMP-binding flagellar brake protein YcgR and the flagellar stator
C1_01279	155864.EDL933_2864	1.6e-166	592.0	Escherichia	motB	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0009288,GO:0009425,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044425,GO:0044459,GO:0044461,GO:0044463,GO:0044464,GO:0071944,GO:0120100,GO:0120101		ko:K02557	ko02030,ko02040,map02030,map02040				ko00000,ko00001,ko02000,ko02035	1.A.30.1			Bacteria	1MW1Y@1224,1RPQ9@1236,3XNZZ@561,COG1360@1,COG1360@2	NA|NA|NA	N	MotA and MotB comprise the stator element of the flagellar motor complex. Required for the rotation of the flagellar motor. Probably a linker that fastens the torque- generating machinery to the cell wall. Overexpression of this protein with MotA improves motility in a yhjH disruption, (a c-di- GMP phosphodiesterase) suggesting there is an interaction (direct or indirect) between the c-di-GMP-binding flagellar brake protein YcgR and the flagellar stator
C1_01280	481805.EcolC_1744	0.0	1228.0	Escherichia	cheA	GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006935,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009892,GO:0009893,GO:0009987,GO:0010562,GO:0010604,GO:0010605,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019220,GO:0019222,GO:0019538,GO:0019904,GO:0023014,GO:0023052,GO:0031323,GO:0031324,GO:0031325,GO:0031399,GO:0031400,GO:0031401,GO:0032101,GO:0032268,GO:0032269,GO:0032270,GO:0032879,GO:0032991,GO:0035303,GO:0035304,GO:0035306,GO:0035307,GO:0035556,GO:0036211,GO:0040011,GO:0040012,GO:0042221,GO:0042330,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0045937,GO:0046777,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0050920,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051179,GO:0051234,GO:0051246,GO:0051247,GO:0051248,GO:0051270,GO:0051641,GO:0051649,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0098561,GO:0140096,GO:1901564,GO:1901873,GO:1901875,GO:1902021,GO:2000145	2.7.13.3	ko:K02487,ko:K03407,ko:K06596	ko02020,ko02025,ko02030,map02020,map02025,map02030	M00506,M00507			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035				Bacteria	1MUAG@1224,1RMS6@1236,3XM5T@561,COG0643@1,COG0643@2,COG2198@1,COG2198@2	NA|NA|NA	NT	Chemotaxis protein cheA
C1_01281	155864.EDL933_2862	8.4e-82	309.7	Escherichia	cheW	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006935,GO:0007154,GO:0007165,GO:0008150,GO:0009605,GO:0009893,GO:0009987,GO:0010604,GO:0016020,GO:0019222,GO:0019904,GO:0023052,GO:0031323,GO:0031325,GO:0031399,GO:0031401,GO:0032268,GO:0032270,GO:0032991,GO:0040011,GO:0042221,GO:0042330,GO:0044424,GO:0044444,GO:0044464,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051179,GO:0051234,GO:0051246,GO:0051247,GO:0051641,GO:0051649,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0098561,GO:1901873,GO:1901875		ko:K03408	ko02020,ko02030,map02020,map02030				ko00000,ko00001,ko02035				Bacteria	1RD1W@1224,1S26J@1236,3XNC7@561,COG0835@1,COG0835@2	NA|NA|NA	NT	Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. It physically bridges CheA to the MCPs (methyl-accepting chemotaxis proteins) to allow regulated phosphotransfer to CheY and CheB
C1_01282	199310.c2301	1.7e-251	875.2	Escherichia	tar	GO:0001101,GO:0003674,GO:0004888,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006935,GO:0007154,GO:0007165,GO:0007172,GO:0008150,GO:0009593,GO:0009605,GO:0009719,GO:0009893,GO:0009966,GO:0009987,GO:0010033,GO:0010243,GO:0010604,GO:0010646,GO:0016020,GO:0016021,GO:0016043,GO:0019222,GO:0019899,GO:0019900,GO:0019901,GO:0022607,GO:0023051,GO:0023052,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031399,GO:0031401,GO:0032101,GO:0032268,GO:0032270,GO:0032991,GO:0034622,GO:0038023,GO:0040011,GO:0040012,GO:0042221,GO:0042330,GO:0042802,GO:0042803,GO:0043200,GO:0043424,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0046983,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0050920,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051259,GO:0051260,GO:0051606,GO:0051716,GO:0060089,GO:0060255,GO:0065003,GO:0065007,GO:0070887,GO:0071229,GO:0071230,GO:0071310,GO:0071417,GO:0071495,GO:0071840,GO:0071944,GO:0080090,GO:0098561,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1901873,GO:1901875		ko:K03406,ko:K05874,ko:K05875	ko02020,ko02030,map02020,map02030				ko00000,ko00001,ko02035				Bacteria	1MU9B@1224,1RMH0@1236,3XMD1@561,COG0840@1,COG0840@2	NA|NA|NA	NT	Methyl-accepting chemotaxis protein II
C1_01283	155864.EDL933_2860	2.2e-248	864.8	Escherichia	tap	GO:0003674,GO:0004888,GO:0005575,GO:0005623,GO:0005886,GO:0006935,GO:0007154,GO:0007165,GO:0008150,GO:0009605,GO:0009987,GO:0016020,GO:0023052,GO:0038023,GO:0040011,GO:0042221,GO:0042330,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0071944		ko:K03406,ko:K05874,ko:K05875,ko:K05876,ko:K05877	ko02020,ko02030,map02020,map02030				ko00000,ko00001,ko02035				Bacteria	1MU9B@1224,1RMH0@1236,3XNE9@561,COG0840@1,COG0840@2	NA|NA|NA	NT	Methyl-accepting chemotaxis protein
C1_01284	481805.EcolC_1748	1.7e-162	578.6	Escherichia	cheR	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006479,GO:0006807,GO:0006935,GO:0008022,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0008983,GO:0009605,GO:0009987,GO:0010340,GO:0016020,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0032991,GO:0036211,GO:0040011,GO:0042221,GO:0042330,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051998,GO:0071704,GO:0071944,GO:0098561,GO:0140096,GO:1901564	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030				ko00000,ko00001,ko01000,ko02035				Bacteria	1MU6W@1224,1RMFK@1236,3XN86@561,COG1352@1,COG1352@2	NA|NA|NA	J	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C1_01285	199310.c2298	3.3e-189	667.5	Escherichia	cheB	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006482,GO:0006807,GO:0006935,GO:0008150,GO:0008152,GO:0008214,GO:0008984,GO:0009605,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0018277,GO:0019538,GO:0019899,GO:0036211,GO:0040011,GO:0042221,GO:0042330,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051723,GO:0052689,GO:0070988,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1990827	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506			ko00000,ko00001,ko00002,ko01000,ko02022,ko02035				Bacteria	1MWCN@1224,1RN67@1236,3XNVQ@561,COG2201@1,COG2201@2	NA|NA|NA	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR
C1_01286	155864.EDL933_2857	4.7e-64	250.4	Escherichia													Bacteria	1RDNP@1224,1S47I@1236,3XPJY@561,COG0745@1,COG0745@2	NA|NA|NA	KT	Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. In its active (phosphorylated or acetylated) form, CheY exhibits enhanced binding to a switch component, FliM, at the flagellar motor which induces a change from counterclockwise to clockwise flagellar rotation
C1_01287	199310.c2296	2.5e-110	404.8	Escherichia	cheZ	GO:0001539,GO:0003674,GO:0003824,GO:0004721,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0006928,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0032991,GO:0036211,GO:0040011,GO:0042578,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071704,GO:0071944,GO:0071973,GO:0071975,GO:0071977,GO:0097588,GO:0098561,GO:0140096,GO:1901564		ko:K03414	ko02030,map02030				ko00000,ko00001,ko02035				Bacteria	1NIV6@1224,1RNG2@1236,3XM8Y@561,COG3143@1,COG3143@2	NA|NA|NA	J	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C1_01288	316407.1736533	7.8e-208	729.6	Escherichia	flhB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02401,ko:K02556,ko:K03229,ko:K04061,ko:K13820	ko02020,ko02030,ko02040,ko03070,map02020,map02030,map02040,map03070	M00332,M00542,M00660			ko00000,ko00001,ko00002,ko02000,ko02035,ko02044	1.A.30.1,3.A.6.1,3.A.6.2,3.A.6.3			Bacteria	1MUWI@1224,1RMHA@1236,3XPDI@561,COG1377@1,COG1377@2	NA|NA|NA	N	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C1_01289	199310.c2293	0.0	1290.8	Escherichia	flhA	GO:0005575,GO:0005623,GO:0005886,GO:0006996,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0022607,GO:0030030,GO:0030031,GO:0044085,GO:0044464,GO:0044780,GO:0044781,GO:0070925,GO:0071840,GO:0071944		ko:K02400	ko02040,map02040				ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3			Bacteria	1MUF3@1224,1RMSM@1236,3XMV8@561,COG1298@1,COG1298@2	NA|NA|NA	N	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C1_01290	316407.1736523	7.7e-67	259.6	Escherichia	flhE	GO:0005575,GO:0005623,GO:0006996,GO:0008150,GO:0009288,GO:0009987,GO:0016043,GO:0030030,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0044781,GO:0071840		ko:K03516					ko00000,ko02035				Bacteria	1RF8K@1224,1S3YK@1236,294I9@1,2ZRXW@2,3XPT0@561	NA|NA|NA	N	Flagellar protein flhE
C1_01291	316407.85675156	2.2e-87	328.2	Gammaproteobacteria	yecT												Bacteria	1NQ0A@1224,1SIE2@1236,COG3755@1,COG3755@2	NA|NA|NA	S	Lysozyme inhibitor LprI
C1_01292	199310.c2291	0.0	1143.3	Escherichia	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029			iECABU_c1320.ECABU_c21380,iECNA114_1301.ECNA114_1940,iECSE_1348.ECSE_2111,iECSF_1327.ECSF_1736,iEcolC_1368.EcolC_1756,iJN746.PP_5089,iLF82_1304.LF82_0128,iNRG857_1313.NRG857_09405,iUMNK88_1353.UMNK88_2348,ic_1306.c2291	Bacteria	1MU4J@1224,1RPRC@1236,3XNTV@561,COG0018@1,COG0018@2	NA|NA|NA	J	arginyl-tRNA aminoacylation
C1_01293	469008.B21_01835	6.5e-107	393.3	Escherichia	yecM	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K09907					ko00000				Bacteria	1RB98@1224,1RYG4@1236,3XP38@561,COG3102@1,COG3102@2	NA|NA|NA	S	YecM protein
C1_01294	481805.EcolC_1758	1.2e-137	495.7	Escherichia	cutC	GO:0006873,GO:0006875,GO:0006878,GO:0008150,GO:0009987,GO:0010035,GO:0010038,GO:0019725,GO:0030003,GO:0042221,GO:0042592,GO:0046688,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0055065,GO:0055070,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0098771		ko:K06201					ko00000				Bacteria	1MV5W@1224,1RMC1@1236,3XP58@561,COG3142@1,COG3142@2	NA|NA|NA	P	Participates in the control of copper homeostasis
C1_01295	481805.EcolC_1759	9.7e-208	729.2	Escherichia	torY	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0020037,GO:0022900,GO:0031224,GO:0031226,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0071944,GO:0097159,GO:1901363		ko:K02569,ko:K03532,ko:K07821	ko02020,map02020				ko00000,ko00001,ko02000	5.A.3.4		iEC042_1314.EC042_1072,iEcolC_1368.EcolC_1448	Bacteria	1MWV2@1224,1RQ52@1236,3XP3J@561,COG3005@1,COG3005@2	NA|NA|NA	C	Part of the anaerobic respiratory chain of trimethylamine-N-oxide reductase TorZ. Required for electron transfer to the TorZ terminal enzyme
C1_01296	469008.B21_01831	0.0	1630.9	Escherichia	torZ	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016661,GO:0016662,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0050626,GO:0055114	1.7.2.3,1.8.5.3	ko:K07306,ko:K07811,ko:K07812,ko:K08351	ko00780,ko00920,ko01100,ko02020,map00780,map00920,map01100,map02020		R09501,R10127	RC02555,RC03056	ko00000,ko00001,ko01000,ko02000	5.A.3.3,5.A.3.4		iEC042_1314.EC042_1073,iEcHS_1320.EcHS_A3752,iEcolC_1368.EcolC_0165,iNRG857_1313.NRG857_09385	Bacteria	1NR6J@1224,1RMVE@1236,3XNTP@561,COG0243@1,COG0243@2	NA|NA|NA	C	an anaerobic reaction coupled to energy-yielding reactions. Can also reduce other N- and S-oxide compounds such as 4-methylmorpholine-N-oxide and biotin sulfoxide (BSO), but with a lower catalytic efficiency
C1_01297	198214.SF1912	7.3e-191	672.9	Gammaproteobacteria	cmoB	GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016740,GO:0016741,GO:0016765,GO:0022607,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:0090304,GO:1901360		ko:K15257					ko00000,ko01000,ko03016				Bacteria	1MVSK@1224,1RMQY@1236,COG0500@1,COG0500@2	NA|NA|NA	J	Catalyzes carboxymethyl transfer from carboxy-S- adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs
C1_01298	155864.EDL933_2844	6.5e-139	500.0	Escherichia	cmoA	GO:0002097,GO:0002098,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360		ko:K15256					ko00000,ko01000,ko03016				Bacteria	1MV4M@1224,1RMWY@1236,3XPCC@561,COG0500@1,COG2226@2	NA|NA|NA	J	Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM)
C1_01299	155864.EDL933_2843	1.3e-66	258.8	Escherichia	yecN	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K07136					ko00000				Bacteria	1RDHP@1224,1S3PN@1236,3XPIH@561,COG3788@1,COG3788@2	NA|NA|NA	S	MAPEG family
C1_01300	316407.85675153	3e-161	574.3	Escherichia	yecE												Bacteria	1MU7F@1224,1RSAG@1236,3XN7Z@561,COG1801@1,COG1801@2	NA|NA|NA	S	Protein of unknown function DUF72
C1_01301	155864.EDL933_2841	6.3e-102	376.7	Escherichia	yecD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Bacteria	1QK2B@1224,1RYRR@1236,3XMT8@561,COG1335@1,COG1335@2	NA|NA|NA	Q	hydrolase activity
C1_01302	481805.EcolC_1766	0.0	1168.7	Escherichia	aspS	GO:0003674,GO:0003824,GO:0004812,GO:0004815,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006422,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029			iJN678.aspS,iSFV_1184.SFV_1868	Bacteria	1MUXB@1224,1RNMI@1236,3XMSA@561,COG0173@1,COG0173@2	NA|NA|NA	J	Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)
C1_01303	481805.EcolC_1767	1.7e-90	338.6	Escherichia	nudB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008828,GO:0009058,GO:0009108,GO:0009110,GO:0009396,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017144,GO:0018130,GO:0019177,GO:0019438,GO:0019752,GO:0034641,GO:0042364,GO:0042398,GO:0042558,GO:0042559,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046655,GO:0046656,GO:0046872,GO:0047429,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.3.1.181,3.6.1.13,3.6.1.55,3.6.1.67	ko:K01515,ko:K03574,ko:K03801,ko:K08310	ko00230,ko00785,ko00790,ko01100,map00230,map00785,map00790,map01100	M00126	R01054,R04638,R07766,R07769	RC00002,RC00039,RC00992,RC02867	ko00000,ko00001,ko00002,ko01000,ko03400			iSFV_1184.SFV_1867,iSF_1195.SF1875,iSFxv_1172.SFxv_2099,iS_1188.S1941,iY75_1357.Y75_RS09795,iYL1228.KPN_02379	Bacteria	1RH6N@1224,1S20Q@1236,3XPM6@561,COG0494@1,COG0494@2	NA|NA|NA	L	Catalyzes the hydrolysis of dihydroneopterin triphosphate to dihydroneopterin monophosphate and pyrophosphate. Required for efficient folate biosynthesis. Can also hydrolyze nucleoside triphosphates with a preference for dATP
C1_01304	155864.EDL933_2838	3.7e-134	484.2	Escherichia	yebC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0044424,GO:0044444,GO:0044464,GO:0050896											Bacteria	1MW3X@1224,1RP5N@1236,3XN2B@561,COG0217@1,COG0217@2	NA|NA|NA	K	transcriptional regulatory protein YebC
C1_01305	1440052.EAKF1_ch4174	9.6e-89	332.8	Escherichia	ruvC	GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576	3.1.22.4	ko:K01159	ko03440,map03440				ko00000,ko00001,ko01000,ko03400				Bacteria	1MUJI@1224,1RQPJ@1236,3XM8U@561,COG0817@1,COG0817@2	NA|NA|NA	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C1_01306	481805.EcolC_1770	2.4e-112	411.4	Escherichia	yebB												Bacteria	1PUT6@1224,1RYQC@1236,28IT1@1,2Z8S1@2,3XM6R@561	NA|NA|NA	S	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
C1_01307	155864.EDL933_2835	2.3e-105	388.3	Escherichia	ruvA	GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494	3.6.4.12	ko:K03550	ko03440,map03440				ko00000,ko00001,ko01000,ko03400				Bacteria	1MWJR@1224,1RMET@1236,3XMI2@561,COG0632@1,COG0632@2	NA|NA|NA	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
C1_01308	155864.EDL933_2834	1.7e-187	661.8	Escherichia	ruvB	GO:0000725,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360	3.6.4.12	ko:K03551	ko03440,map03440				ko00000,ko00001,ko01000,ko03400				Bacteria	1MU38@1224,1RNWY@1236,3XMBC@561,COG2255@1,COG2255@2	NA|NA|NA	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
C1_01309	362663.ECP_1803	8.1e-124	449.9	Escherichia	znuB	GO:0000006,GO:0000041,GO:0003674,GO:0005215,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008150,GO:0008324,GO:0010035,GO:0010038,GO:0010043,GO:0015075,GO:0015318,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0042221,GO:0044464,GO:0046873,GO:0046915,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662		ko:K02075,ko:K09816	ko02010,map02010	M00242,M00244			ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5		iEC042_1314.EC042_2026,iECABU_c1320.ECABU_c21210,iECED1_1282.ECED1_2064,iECNA114_1301.ECNA114_1921,iECSF_1327.ECSF_1717,iECUMN_1333.ECUMN_2157,iEcSMS35_1347.EcSMS35_1327,iG2583_1286.G2583_2311,iSSON_1240.SSON_1282,iYL1228.KPN_02374,ic_1306.c2273	Bacteria	1MVC2@1224,1RPYF@1236,3XMDE@561,COG1108@1,COG1108@2	NA|NA|NA	P	High-affinity zinc uptake system membrane protein ZnuB
C1_01310	155864.EDL933_2832	4.5e-140	503.8	Escherichia	znuC	GO:0000041,GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005385,GO:0005488,GO:0005524,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008144,GO:0008150,GO:0008324,GO:0015075,GO:0015318,GO:0015399,GO:0015405,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043492,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0072509,GO:0072511,GO:0097159,GO:0097367,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901363		ko:K02074,ko:K09817	ko02010,map02010	M00242,M00244			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5		iSFV_1184.SFV_1859,iSF_1195.SF1867,iSFxv_1172.SFxv_2092,iS_1188.S1934	Bacteria	1MUDW@1224,1RPJT@1236,3XNTN@561,COG1121@1,COG1121@2	NA|NA|NA	P	Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system
C1_01311	198214.SF1868	5e-179	633.6	Gammaproteobacteria	znuA	GO:0000041,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008150,GO:0008270,GO:0030001,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0051179,GO:0051234,GO:0070838,GO:0072511		ko:K09815	ko02010,map02010	M00242			ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5		iECs_1301.ECs2567,iEcSMS35_1347.EcSMS35_1329,iPC815.YPO2061,iZ_1308.Z2909	Bacteria	1QTTI@1224,1RMRJ@1236,COG4531@1,COG4531@2	NA|NA|NA	P	ABC-type Zn2 transport system, periplasmic component surface adhesin
C1_01312	155864.EDL933_2830	1.8e-248	864.8	Escherichia	yebA	GO:0000270,GO:0000920,GO:0001896,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0006022,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008219,GO:0008233,GO:0008237,GO:0009987,GO:0012501,GO:0016787,GO:0019538,GO:0030203,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0140096,GO:1901135,GO:1901564		ko:K19304,ko:K21472					ko00000,ko01000,ko01002,ko01011				Bacteria	1MVTF@1224,1RM7S@1236,3XP5M@561,COG0739@1,COG0739@2	NA|NA|NA	M	A murein DD-endopeptidase with specificity for D-Ala- meso-diaminopimelic acid (mDAP) cross-links. Its role is probably to cleave D-Ala-mDAP cross-links to allow insertion of new glycans and thus cell wall expansion. Functionally redundant with MepM and MepH
C1_01313	316407.1736498	1.6e-190	671.8	Escherichia	lpxM	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006082,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008951,GO:0009058,GO:0009245,GO:0009247,GO:0009266,GO:0009311,GO:0009312,GO:0009409,GO:0009628,GO:0009987,GO:0016020,GO:0016051,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0019752,GO:0036103,GO:0036104,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046467,GO:0046493,GO:0050896,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.3.1.241,2.3.1.242,2.3.1.243	ko:K02517,ko:K02560,ko:K12974	ko00540,ko01100,map00540,map01100	M00060	R05075,R05146,R10906	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005			iEC042_1314.EC042_2597,iECABU_c1320.ECABU_c21170,iECIAI39_1322.ECIAI39_1194,iSF_1195.SF1061,iS_1188.S1138,ic_1306.c2269	Bacteria	1N9ZJ@1224,1RRI7@1236,3XND2@561,COG1560@1,COG1560@2	NA|NA|NA	M	Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)-lipid A
C1_01314	316407.1736497	6.2e-263	912.9	Escherichia	pyk	GO:0003674,GO:0003824,GO:0004743,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016020,GO:0016043,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042802,GO:0042866,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147			e_coli_core.b1854,iAF1260.b1854,iB21_1397.B21_01813,iBWG_1329.BWG_1668,iEC042_1314.EC042_2021,iECBD_1354.ECBD_1784,iECB_1328.ECB_01825,iECDH10B_1368.ECDH10B_1995,iECDH1ME8569_1439.ECDH1ME8569_1801,iECD_1391.ECD_01825,iECO103_1326.ECO103_1819,iECO103_1326.ECO103_2044,iECO111_1330.ECO111_2362,iECO26_1355.ECO26_2692,iECUMN_1333.ECUMN_2152,iETEC_1333.ETEC_1887,iEcDH1_1363.EcDH1_1786,iEcE24377_1341.EcE24377A_2084,iEcHS_1320.EcHS_A1947,iEcSMS35_1347.EcSMS35_1332,iEcolC_1368.EcolC_1778,iG2583_1286.G2583_2306,iJO1366.b1854,iJR904.b1854,iSBO_1134.SBO_1162,iSSON_1240.SSON_1294,iSbBS512_1146.SbBS512_E2130,iUMNK88_1353.UMNK88_2326,iY75_1357.Y75_RS09740	Bacteria	1MU21@1224,1RMW3@1236,3XPGP@561,COG0469@1,COG0469@2	NA|NA|NA	F	Belongs to the pyruvate kinase family
C1_01315	155864.EDL933_2827	1.7e-154	552.0	Escherichia	hexR	GO:0000976,GO:0001067,GO:0001130,GO:0001131,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0033554,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K15835,ko:K19337					ko00000,ko03000				Bacteria	1MV3U@1224,1RNC4@1236,3XM9I@561,COG1737@1,COG1737@2	NA|NA|NA	K	transcription factor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding
C1_01317	199310.c2265	2.6e-288	997.3	Escherichia	zwf	GO:0003674,GO:0003824,GO:0004345,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007267,GO:0008150,GO:0008152,GO:0009117,GO:0009372,GO:0009987,GO:0010699,GO:0016491,GO:0016614,GO:0016616,GO:0019318,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0023052,GO:0034641,GO:0042802,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0051704,GO:0055086,GO:0055114,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147			e_coli_core.b1852,iAF1260.b1852,iBWG_1329.BWG_1666,iE2348C_1286.E2348C_1977,iEC042_1314.EC042_2019,iECABU_c1320.ECABU_c21130,iECDH10B_1368.ECDH10B_1993,iECDH1ME8569_1439.ECDH1ME8569_1798,iECED1_1282.ECED1_2057,iECIAI39_1322.ECIAI39_1198,iECNA114_1301.ECNA114_1899,iECO26_1355.ECO26_2690,iECP_1309.ECP_1796,iECSF_1327.ECSF_1710,iECUMN_1333.ECUMN_2149,iECW_1372.ECW_m2026,iEKO11_1354.EKO11_1918,iEcDH1_1363.EcDH1_1789,iEcE24377_1341.EcE24377A_2082,iEcHS_1320.EcHS_A1944,iEcSMS35_1347.EcSMS35_1335,iEcolC_1368.EcolC_1780,iG2583_1286.G2583_2304,iJO1366.b1852,iJR904.b1852,iLF82_1304.LF82_3733,iNRG857_1313.NRG857_09280,iSDY_1059.SDY_1138,iWFL_1372.ECW_m2026,iY75_1357.Y75_RS09725,iYL1228.KPN_02367,ic_1306.c2265	Bacteria	1MUN0@1224,1RN76@1236,3XNAE@561,COG0364@1,COG0364@2	NA|NA|NA	F	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C1_01318	155864.EDL933_2824	0.0	1200.3	Escherichia	edd	GO:0003674,GO:0003824,GO:0004456,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019520,GO:0019521,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046177,GO:0046395,GO:0071704,GO:0072329,GO:1901575	4.2.1.12	ko:K01690	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00008	R02036	RC00543	ko00000,ko00001,ko00002,ko01000			iEcolC_1368.EcolC_1781,iJN746.PP_1010,iPC815.YPO2533,iYL1228.KPN_02366	Bacteria	1MU3T@1224,1RMNA@1236,3XMWD@561,COG0129@1,COG0129@2	NA|NA|NA	EG	Belongs to the IlvD Edd family
C1_01319	1440052.EAKF1_ch4190	1.8e-113	415.2	Escherichia	eda	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008675,GO:0008700,GO:0008948,GO:0016829,GO:0016830,GO:0016831,GO:0016832,GO:0016833,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0106009	4.1.2.14,4.1.3.42	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	M00008,M00061,M00308,M00631	R00470,R05605	RC00307,RC00308,RC00435	ko00000,ko00001,ko00002,ko01000			iECOK1_1307.ECOK1_1968,iYL1228.KPN_02365	Bacteria	1MUVJ@1224,1RPDF@1236,3XNXS@561,COG0800@1,COG0800@2	NA|NA|NA	G	Involved in the degradation of glucose via the Entner- Doudoroff pathway. Catalyzes the reversible, stereospecific retro- aldol cleavage of 2-Keto-3-deoxy-6-phosphogluconate (KDPG) to pyruvate and D-glyceraldehyde-3-phosphate. In the synthetic direction, it catalyzes the addition of pyruvate to electrophilic aldehydes with si-facial selectivity. It accepts some nucleophiles other than pyruvate, including 2-oxobutanoate, phenylpyruvate, and fluorobutanoate. It has a preference for the S-configuration at C2 of the electrophile
C1_01320	469008.B21_01808	3.8e-218	763.8	Escherichia	purT	GO:0003674,GO:0003824,GO:0004644,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008776,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016741,GO:0016742,GO:0016772,GO:0016774,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.2.2	ko:K08289	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000			iNJ661.Rv0389,iSDY_1059.SDY_1135	Bacteria	1N3KA@1224,1RNTW@1236,3XMXH@561,COG0027@1,COG0027@2	NA|NA|NA	F	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C1_01321	155864.EDL933_2821	1.4e-44	185.3	Escherichia	yebG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0010165,GO:0010212,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360		ko:K09918					ko00000				Bacteria	1N6RQ@1224,1SCDB@1236,3XPUH@561,COG3141@1,COG3141@2	NA|NA|NA	S	response to X-ray
C1_01322	155864.EDL933_2820	7.5e-61	239.6	Escherichia	yebF												Bacteria	1RIMG@1224,1S6EJ@1236,2DM3Z@1,31MN2@2,3XPTU@561	NA|NA|NA	S	YebF-like protein
C1_01325	469008.B21_01805	1.1e-113	416.0	Escherichia	yebE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1R95E@1224,1S2WZ@1236,3XPA7@561,COG2979@1,COG2979@2	NA|NA|NA	S	Protein of unknown function (DUF533)
C1_01326	469008.B21_01804	0.0	1412.1	Escherichia	ptrB	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0070011,GO:0070012,GO:0071704,GO:0140096,GO:1901564	3.4.21.83	ko:K01354	ko05142,ko05143,map05142,map05143				ko00000,ko00001,ko01000,ko01002				Bacteria	1MUED@1224,1RMSV@1236,3XPAW@561,COG1770@1,COG1770@2	NA|NA|NA	E	oligopeptidase activity
C1_01327	199310.c2254	5.1e-127	460.3	Escherichia	exoX	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:1901360		ko:K10857	ko03430,map03430				ko00000,ko00001,ko01000,ko03400				Bacteria	1PDD1@1224,1RNSI@1236,3XNFX@561,COG0847@1,COG0847@2	NA|NA|NA	L	Capable of degrading both single-strand and double- strand DNA with 3' to 5' polarity. Has higher affinity for ssDNA ends than for dsDNA
C1_01328	316407.85675147	5.2e-124	450.3	Escherichia	yobB		6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000				Bacteria	1RESJ@1224,1S5NI@1236,3XPIU@561,COG0388@1,COG0388@2	NA|NA|NA	S	nitrogen compound metabolic process
C1_01329	155864.EDL933_2815	1.7e-34	151.4	Escherichia	holE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009360,GO:0032991,GO:0042575,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0061695,GO:1902494,GO:1990234	2.7.7.7	ko:K02345	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Bacteria	1MZTI@1224,1S8YF@1236,2CFYS@1,32S2T@2,3XPYS@561	NA|NA|NA	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C1_01330	198214.SF1852	2.2e-63	248.1	Gammaproteobacteria	yobA	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464		ko:K07156					ko00000,ko02000	9.B.62.2			Bacteria	1N8SS@1224,1S9EF@1236,COG2372@1,COG2372@2	NA|NA|NA	S	Resistance protein
C1_01331	481805.EcolC_1792	2.5e-158	564.7	Escherichia	yebZ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K07245					ko00000,ko02000	9.B.62.1			Bacteria	1P1D5@1224,1RYS7@1236,3XMS8@561,COG1276@1,COG1276@2	NA|NA|NA	P	copper ion transport
C1_01332	469008.B21_01798	2.6e-55	221.1	Escherichia	yebY	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Bacteria	1N3F9@1224,1SAPJ@1236,2DMVD@1,32TXR@2,3XPPC@561	NA|NA|NA	S	Protein of unknown function (DUF2511)
C1_01333	481805.EcolC_1794	2.2e-130	471.5	Escherichia	pphA	GO:0003674,GO:0003824,GO:0004721,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008138,GO:0008150,GO:0008152,GO:0009266,GO:0009628,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0071704,GO:0140096,GO:1901564	3.1.3.16	ko:K07313					ko00000,ko01000				Bacteria	1N106@1224,1S9QJ@1236,3XNX2@561,COG0639@1,COG0639@2	NA|NA|NA	T	Plays a key role in signaling protein misfolding via the CpxR CPXA transducing system. It also modulates the phosphorylated status of many phosphoproteins in E.coli, some of which acting as major chaperones. Has been shown, in vitro, to act on Ser, Thr and Tyr-phosphorylated substrates
C1_01334	198214.SF1388	2.7e-50	204.1	Gammaproteobacteria	yebW												Bacteria	1N7FC@1224,1SCUH@1236,2E3KM@1,32YIX@2	NA|NA|NA	S	Protein of unknown function (DUF1482)
C1_01335	155864.EDL933_2809	8.2e-40	169.1	Escherichia	yebV												Bacteria	1N1QN@1224,1S96J@1236,2D1TW@1,32TBC@2,3XQ0D@561	NA|NA|NA	S	Protein of unknown function (DUF1480)
C1_01336	469008.B21_01794	2.1e-282	977.6	Escherichia	rsmF	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.176,2.1.1.178	ko:K03500,ko:K11392,ko:K22446					ko00000,ko01000,ko03009,ko03016				Bacteria	1NAY1@1224,1RP74@1236,3XP8F@561,COG0144@1,COG0144@2,COG3270@1,COG3270@2	NA|NA|NA	J	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
C1_01337	469008.B21_01793	0.0	1716.4	Escherichia	yebT	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006869,GO:0008150,GO:0009987,GO:0010876,GO:0016020,GO:0016021,GO:0016043,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0033036,GO:0042597,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071840,GO:0071944,GO:0120009		ko:K06192					ko00000				Bacteria	1MU1T@1224,1RN89@1236,3XNTJ@561,COG3008@1,COG3008@2	NA|NA|NA	Q	intermembrane lipid transfer
C1_01338	469008.B21_01792	4.1e-242	843.6	Escherichia	yebS	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0071944		ko:K03808					ko00000				Bacteria	1MWG1@1224,1RM9Z@1236,3XM56@561,COG2995@1,COG2995@2	NA|NA|NA	S	response to heat
C1_01339	469008.B21_01791	1.3e-99	369.0	Escherichia	yebR	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016667,GO:0016671,GO:0033745,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.8.4.14	ko:K08968	ko00270,map00270		R02025	RC00639	ko00000,ko00001,ko01000				Bacteria	1RDBM@1224,1S6QU@1236,3XN26@561,COG1956@1,COG1956@2	NA|NA|NA	T	L-methionine-(R)-S-oxide reductase activity
C1_01340	198214.SF1394	3.6e-115	421.0	Gammaproteobacteria	proQ	GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003727,GO:0003729,GO:0003730,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006970,GO:0006972,GO:0006974,GO:0007154,GO:0007165,GO:0007231,GO:0008150,GO:0009628,GO:0009651,GO:0009987,GO:0010468,GO:0010608,GO:0010958,GO:0019222,GO:0023052,GO:0032879,GO:0032890,GO:0032892,GO:0033554,GO:0033592,GO:0034057,GO:0034762,GO:0034764,GO:0034765,GO:0034767,GO:0042538,GO:0042710,GO:0043269,GO:0043270,GO:0044010,GO:0044070,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0048518,GO:0050789,GO:0050794,GO:0050896,GO:0051049,GO:0051050,GO:0051704,GO:0051716,GO:0051952,GO:0051954,GO:0051955,GO:0051957,GO:0060255,GO:0065007,GO:0070881,GO:0071214,GO:0071470,GO:0071472,GO:0071474,GO:0071475,GO:0097159,GO:0097617,GO:0104004,GO:1901363,GO:1902834,GO:1902836,GO:1903789,GO:1903793,GO:1903959,GO:1903961,GO:1904062,GO:1904064		ko:K03607					ko00000				Bacteria	1N68T@1224,1RP4S@1236,COG3109@1,COG3109@2	NA|NA|NA	T	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
C1_01341	469008.B21_01789	0.0	1323.5	Escherichia	prc	GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0023052,GO:0030163,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575	3.4.21.102	ko:K03797					ko00000,ko01000,ko01002				Bacteria	1MU39@1224,1RMSR@1236,3XN0R@561,COG0793@1,COG0793@2	NA|NA|NA	M	Belongs to the peptidase S41A family
C1_01342	155864.EDL933_2802	1.9e-153	548.5	Escherichia	htpX	GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0016020,GO:0016021,GO:0016787,GO:0019538,GO:0031224,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044425,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564		ko:K03799		M00743			ko00000,ko00002,ko01000,ko01002				Bacteria	1MUV4@1224,1RMN0@1236,3XPBP@561,COG0501@1,COG0501@2	NA|NA|NA	O	Heat shock protein HtpX
C1_01343	316407.1736469	2.2e-241	841.3	Escherichia	yebQ	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944		ko:K08169					ko00000,ko02000	2.A.1.3.17			Bacteria	1QUAS@1224,1RPFC@1236,3XP7S@561,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
C1_01344	155864.EDL933_2800	4.8e-140	503.8	Escherichia	kdgR	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K19333					ko00000,ko03000				Bacteria	1MUNW@1224,1RR06@1236,3XP0S@561,COG1414@1,COG1414@2	NA|NA|NA	K	Transcriptional regulator
C1_01345	199310.c2235	5.6e-36	156.4	Escherichia	yobH												Bacteria	1N493@1224,1S97R@1236,2CYZ3@1,32T57@2,3XQ3X@561	NA|NA|NA	S	YobH-like protein
C1_01346	199310.c2233	8.5e-39	166.0	Escherichia	yebO												Bacteria	1N0RQ@1224,1S9E7@1236,2CGCJ@1,32S3N@2,3XPY1@561	NA|NA|NA	S	YebO-like protein
C1_01347	1005994.GTGU_00244	2.5e-32	144.1	Gammaproteobacteria	cspC	GO:0001072,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006950,GO:0008150,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031554,GO:0031564,GO:0043242,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051087,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0060567,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K03704					ko00000,ko03000			iECW_1372.ECW_m0678,iWFL_1372.ECW_m0678	Bacteria	1N6Q5@1224,1SCA7@1236,COG1278@1,COG1278@2	NA|NA|NA	K	Cold shock
C1_01348	198214.SF1404	2.7e-154	551.2	Gammaproteobacteria	rrmA	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008270,GO:0008649,GO:0008757,GO:0008989,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0052912,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.187	ko:K00563			R07233	RC00003	ko00000,ko01000,ko03009				Bacteria	1MXDY@1224,1RMU7@1236,COG0500@1,COG2226@2	NA|NA|NA	Q	Methyl-transferase
C1_01349	155864.EDL933_2793	3.8e-99	367.5	Escherichia	mntP	GO:0000041,GO:0003674,GO:0005215,GO:0005384,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006828,GO:0008150,GO:0008324,GO:0010035,GO:0010038,GO:0010042,GO:0015075,GO:0015318,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0042221,GO:0044464,GO:0046873,GO:0046915,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071421,GO:0071944,GO:0098655,GO:0098660,GO:0098662											Bacteria	1NWBY@1224,1RR6R@1236,3XMT7@561,COG1971@1,COG1971@2	NA|NA|NA	P	Probably functions as a manganese efflux pump
C1_01351	199310.c2227	1.5e-74	285.4	Escherichia	yobD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1RDEQ@1224,1S3UZ@1236,3XMU3@561,COG4811@1,COG4811@2	NA|NA|NA	S	UPF0266 membrane protein YobD
C1_01352	155864.EDL933_2789	7.4e-155	553.1	Escherichia	manZ	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0008645,GO:0008982,GO:0009401,GO:0015144,GO:0015145,GO:0015149,GO:0015578,GO:0015749,GO:0015761,GO:0016020,GO:0016021,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0022870,GO:0031224,GO:0031226,GO:0034219,GO:0044425,GO:0044459,GO:0044464,GO:0046323,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098657,GO:0098704,GO:0098708,GO:0098739,GO:1904659		ko:K02747,ko:K02796,ko:K02815,ko:K10986	ko00051,ko00052,ko00520,ko01100,ko02060,map00051,map00052,map00520,map01100,map02060	M00276,M00277,M00278,M00287	R02630,R04076,R08366,R08367	RC00017,RC01069,RC03206	ko00000,ko00001,ko00002,ko02000	4.A.6.1,4.A.6.1.3,4.A.6.1.4,4.A.6.1.5		iECIAI1_1343.ECIAI1_1888,iECO103_1326.ECO103_3880,iECO111_1330.ECO103_3880,iECP_1309.ECP_1762,iSBO_1134.SBO_1231,iSF_1195.SF1409,iSFxv_1172.SFxv_1596,iS_1188.S1524,iUTI89_1310.UTI89_C3571,ic_1306.c3897	Bacteria	1MWTZ@1224,1RNSD@1236,3XNSC@561,COG3716@1,COG3716@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ManXYZ PTS system is involved in mannose transport. Also functions as a receptor for bacterial chemotaxis and is required for infection of the cell by bacteriophage lambda where it most likely functions as a pore for penetration of lambda DNA
C1_01353	155864.EDL933_2788	4.4e-133	480.7	Escherichia	manY	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0008645,GO:0008982,GO:0009401,GO:0015144,GO:0015145,GO:0015149,GO:0015578,GO:0015749,GO:0015761,GO:0016020,GO:0016021,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0022870,GO:0031224,GO:0031226,GO:0034219,GO:0044425,GO:0044459,GO:0044464,GO:0046323,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098657,GO:0098704,GO:0098708,GO:0098739,GO:1904659		ko:K02795,ko:K02796,ko:K02814	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	M00276,M00278	R02630,R04076	RC00017,RC01069,RC03206	ko00000,ko00001,ko00002,ko02000	4.A.6.1,4.A.6.1.3		e_coli_core.b1818,iAF1260.b1818,iAPECO1_1312.APECO1_875,iB21_1397.B21_01776,iBWG_1329.BWG_1631,iE2348C_1286.E2348C_1942,iEC55989_1330.EC55989_1991,iECABU_c1320.ECABU_c20770,iECBD_1354.ECBD_1823,iECB_1328.ECB_01788,iECDH10B_1368.ECDH10B_1956,iECDH1ME8569_1439.ECDH1ME8569_1763,iECD_1391.ECD_01788,iECED1_1282.ECED1_2021,iECH74115_1262.ECH74115_2547,iECIAI1_1343.ECIAI1_1887,iECIAI39_1322.ECIAI39_1234,iECNA114_1301.ECNA114_1863,iECO103_1326.ECO103_2008,iECO111_1330.ECO111_2325,iECO26_1355.ECO26_2588,iECOK1_1307.ECOK1_1935,iECP_1309.ECP_1761,iECS88_1305.ECS88_1870,iECSE_1348.ECSE_1992,iECSF_1327.ECSF_1674,iECSP_1301.ECSP_2391,iECUMN_1333.ECUMN_2110,iECW_1372.ECW_m1988,iECs_1301.ECs2528,iEKO11_1354.EKO11_1954,iETEC_1333.ETEC_1850,iEcDH1_1363.EcDH1_1825,iEcHS_1320.EcHS_A1908,iEcSMS35_1347.EcSMS35_1370,iEcolC_1368.EcolC_1814,iG2583_1286.G2583_2267,iJO1366.b1818,iJR904.b1818,iLF82_1304.LF82_1272,iNRG857_1313.NRG857_09090,iSBO_1134.SBO_1230,iSFV_1184.SFV_1411,iSF_1195.SF1410,iSFxv_1172.SFxv_1597,iSSON_1240.SSON_1342,iS_1188.S1525,iSbBS512_1146.SbBS512_E2084,iUMN146_1321.UM146_08080,iUMNK88_1353.UMNK88_2288,iUTI89_1310.UTI89_C2015,iWFL_1372.ECW_m1988,iY75_1357.Y75_RS09530,iYL1228.KPN_02334,iZ_1308.Z2861,ic_1306.c2224	Bacteria	1MWFP@1224,1RN34@1236,3XM9G@561,COG3715@1,COG3715@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ManXYZ PTS system is involved in mannose transport. Also functions as a receptor for bacterial chemotaxis and is required for infection of the cell by bacteriophage lambda where it most likely functions as a pore for penetration of lambda DNA
C1_01354	155864.EDL933_2787	1.6e-174	618.6	Escherichia	manX	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006793,GO:0006796,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0008645,GO:0008982,GO:0009401,GO:0009987,GO:0015144,GO:0015145,GO:0015149,GO:0015578,GO:0015749,GO:0015761,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0022870,GO:0031224,GO:0031226,GO:0034219,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046323,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098657,GO:0098704,GO:0098708,GO:0098739,GO:1904659	2.7.1.191,2.7.1.206	ko:K02793,ko:K02794,ko:K02812,ko:K02813	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	M00276,M00278	R02630,R04076	RC00017,RC01069,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.6.1,4.A.6.1.3		iAPECO1_1312.APECO1_874,iECOK1_1307.ECOK1_1934,iECS88_1305.ECS88_1869,iPC815.YPO1758,iUMN146_1321.UM146_08085,iUTI89_1310.UTI89_C2014	Bacteria	1RHH7@1224,1RNAT@1236,3XMS9@561,COG2893@1,COG2893@2,COG3444@1,COG3444@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ManXYZ PTS system is involved in mannose transport. Also functions as a receptor for bacterial chemotaxis and is required for infection of the cell by bacteriophage lambda where it most likely functions as a pore for penetration of lambda DNA
C1_01356	155864.EDL933_2786	7.6e-283	979.2	Escherichia	yoaE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03699					ko00000,ko02042				Bacteria	1QTUN@1224,1RMTY@1236,3XNWV@561,COG1253@1,COG1253@2	NA|NA|NA	P	UPF0053 inner membrane protein YoaE
C1_01357	316407.1736452	4.3e-305	1053.1	Escherichia	yoaD	GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016787,GO:0016788,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033554,GO:0042578,GO:0043565,GO:0044212,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071111,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141	3.1.4.52	ko:K13244,ko:K21090	ko02026,map02026		R08991	RC00296	ko00000,ko00001,ko01000				Bacteria	1QUCV@1224,1T1TN@1236,3XNZ2@561,COG2200@1,COG2200@2	NA|NA|NA	T	overexpression inhibits cell aggregation in strains able to produce adhesive curli fimbriae. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria
C1_01358	316407.1736451	1.9e-261	907.9	Escherichia	sdaA	GO:0003674,GO:0003824,GO:0003941,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006563,GO:0006565,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016829,GO:0016840,GO:0016841,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	4.3.1.17	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230		R00220,R00590	RC00331,RC02600	ko00000,ko00001,ko01000			iECSP_1301.ECSP_4084,iECUMN_1333.ECUMN_2106	Bacteria	1MUZN@1224,1RMJZ@1236,3XN8Q@561,COG1760@1,COG1760@2	NA|NA|NA	E	L-serine dehydratase 1
C1_01359	155864.EDL933_2783	2.2e-102	378.3	Escherichia	nudL	GO:0003674,GO:0003824,GO:0016787,GO:0016817,GO:0016818											Bacteria	1RD2C@1224,1SA4Q@1236,3XMZ7@561,COG0494@1,COG0494@2	NA|NA|NA	F	Probably mediates the hydrolysis of some nucleoside diphosphate derivatives
C1_01360	469008.B21_01770	1.9e-261	907.9	Escherichia	pabB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046820,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.6.1.85	ko:K01665,ko:K13950	ko00790,map00790		R01716	RC00010,RC01418	ko00000,ko00001,ko01000			iEC042_1314.EC042_1977	Bacteria	1MVBJ@1224,1RMSE@1236,3XMTG@561,COG0147@1,COG0147@2	NA|NA|NA	EH	Part of a heterodimeric complex that catalyzes the two- step biosynthesis of 4-amino-4-deoxychorismate (ADC), a precursor of p-aminobenzoate (PABA) and tetrahydrofolate. In the first step, a glutamine amidotransferase (PabA) generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by aminodeoxychorismate synthase (PabB) to produce ADC. PabB, in the absence of PabA, can catalyze the formation of ADC in the presence of exogenous ammonia
C1_01361	1440052.EAKF1_ch4240	9.1e-23	112.1	Escherichia	yoaH			ko:K09917					ko00000				Bacteria	1N89H@1224,1SCHP@1236,3XQ2T@561,COG3140@1,COG3140@2	NA|NA|NA	S	Belongs to the UPF0181 family
C1_01362	362663.ECP_1753	1.2e-48	198.7	Escherichia	yoaC												Bacteria	1MZA9@1224,1SAKQ@1236,2DMW3@1,32UHS@2,3XQ17@561	NA|NA|NA	S	Domain of unknown function (DUF1889)
C1_01363	198214.SF1419	4.4e-58	230.3	Gammaproteobacteria	yoaB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Bacteria	1MZ5K@1224,1S5WM@1236,COG0251@1,COG0251@2	NA|NA|NA	J	Translation Initiation Inhibitor YjgF Family
C1_01364	155864.EDL933_2776	0.0	1255.7	Escherichia	dinG	GO:0003674,GO:0003824,GO:0004386,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008026,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:1901360	3.6.4.12	ko:K03722					ko00000,ko01000,ko03400				Bacteria	1MVCU@1224,1RMNX@1236,3XN9U@561,COG1199@1,COG1199@2	NA|NA|NA	KL	postreplication repair
C1_01365	362663.ECP_1750	6.1e-131	473.4	Escherichia	yeaZ	GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0071944,GO:0090304,GO:0140096,GO:1901360,GO:1901564	2.3.1.234	ko:K01409,ko:K14742			R10648	RC00070,RC00416	ko00000,ko01000,ko03016				Bacteria	1MXPH@1224,1RPYX@1236,3XMQ9@561,COG1214@1,COG1214@2	NA|NA|NA	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaE. TsaB seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD. In fact, can act as a protease that specifically degrades TsaD in vitro
C1_01366	199310.c2210	1.1e-106	392.5	Escherichia	yeaY			ko:K07285					ko00000				Bacteria	1MZ8C@1224,1S9UB@1236,3XPCY@561,COG3065@1,COG3065@2	NA|NA|NA	M	Outer membrane lipoprotein Slp family
C1_01367	481805.EcolC_1828	0.0	1161.4	Escherichia	fadD	GO:0001676,GO:0003674,GO:0003824,GO:0004467,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006635,GO:0006637,GO:0006644,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009056,GO:0009058,GO:0009062,GO:0009117,GO:0009150,GO:0009259,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009898,GO:0009987,GO:0015645,GO:0016020,GO:0016042,GO:0016054,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0019395,GO:0019637,GO:0019693,GO:0019752,GO:0030258,GO:0031406,GO:0032787,GO:0033293,GO:0033865,GO:0033875,GO:0034032,GO:0034440,GO:0034641,GO:0035383,GO:0036041,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046395,GO:0046483,GO:0050896,GO:0051186,GO:0055086,GO:0055114,GO:0070538,GO:0071704,GO:0071944,GO:0072329,GO:0072521,GO:0090407,GO:0098552,GO:0098562,GO:1901135,GO:1901360,GO:1901564,GO:1901575,GO:1901576	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1		iSF_1195.SF1423,iSFxv_1172.SFxv_1611,iS_1188.S1538	Bacteria	1MU6G@1224,1RMQ4@1236,3XMU8@561,COG0318@1,COG0318@2	NA|NA|NA	IQ	Catalyzes the esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids
C1_01368	155864.EDL933_2772	1.1e-214	752.3	Escherichia	rnd	GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0033890,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360	3.1.13.5	ko:K03684					ko00000,ko01000,ko03016				Bacteria	1MURV@1224,1RPBP@1236,3XM58@561,COG0349@1,COG0349@2	NA|NA|NA	J	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C1_01369	481805.EcolC_1830	3.6e-182	644.0	Escherichia	yeaX		1.14.13.238,1.14.13.239	ko:K22343,ko:K22444					ko00000,ko01000				Bacteria	1MU6E@1224,1RNA4@1236,3XQNN@561,COG1018@1,COG1018@2	NA|NA|NA	C	Converts carnitine to trimethylamine and malic semialdehyde. Can also use gamma-butyrobetaine, choline and betaine as substrates
C1_01370	155864.EDL933_2770	1.3e-184	652.1	Escherichia	yeaW	GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0042802,GO:0043933,GO:0044085,GO:0048037,GO:0051259,GO:0051260,GO:0051536,GO:0051537,GO:0051540,GO:0065003,GO:0070206,GO:0070207,GO:0071840	1.14.13.239	ko:K22443					ko00000,ko01000				Bacteria	1MWXW@1224,1RYN7@1236,3XQJJ@561,COG4638@1,COG4638@2	NA|NA|NA	P	Belongs to the bacterial ring-hydroxylating dioxygenase alpha subunit family. CntA subfamily
C1_01371	155864.EDL933_2770	2.3e-18	97.4	Escherichia	yeaW	GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0042802,GO:0043933,GO:0044085,GO:0048037,GO:0051259,GO:0051260,GO:0051536,GO:0051537,GO:0051540,GO:0065003,GO:0070206,GO:0070207,GO:0071840	1.14.13.239	ko:K22443					ko00000,ko01000				Bacteria	1MWXW@1224,1RYN7@1236,3XQJJ@561,COG4638@1,COG4638@2	NA|NA|NA	P	Belongs to the bacterial ring-hydroxylating dioxygenase alpha subunit family. CntA subfamily
C1_01372	155864.EDL933_2769	6.5e-63	246.5	Escherichia	yeaV	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0016020,GO:0044464,GO:0051179,GO:0051234,GO:0071705,GO:0071944		ko:K03451					ko00000	2.A.15		iEcSMS35_1347.EcSMS35_1387	Bacteria	1MV0K@1224,1RP3E@1236,3XQSW@561,COG1292@1,COG1292@2	NA|NA|NA	M	nitrogen compound transport
C1_01373	155864.EDL933_2769	3.2e-228	797.3	Escherichia	yeaV	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0016020,GO:0044464,GO:0051179,GO:0051234,GO:0071705,GO:0071944		ko:K03451					ko00000	2.A.15		iEcSMS35_1347.EcSMS35_1387	Bacteria	1MV0K@1224,1RP3E@1236,3XQSW@561,COG1292@1,COG1292@2	NA|NA|NA	M	nitrogen compound transport
C1_01374	316407.1736423	2.4e-214	751.1	Escherichia	dmlA	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003862,GO:0005488,GO:0006082,GO:0006108,GO:0008150,GO:0008152,GO:0009027,GO:0009987,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0019752,GO:0036094,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044281,GO:0046553,GO:0046872,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363	1.1.1.83,1.1.1.93,4.1.1.73	ko:K07246	ko00630,ko00650,map00630,map00650		R00215,R01751,R02545,R06180	RC00084,RC00105,RC00594	ko00000,ko00001,ko01000			iSBO_1134.SBO_1288,ic_1306.c2207	Bacteria	1MUH4@1224,1RRPI@1236,3XQKY@561,COG0473@1,COG0473@2	NA|NA|NA	C	Catalyzes the NAD( )-dependent oxidative decarboxylation of D-malate into pyruvate. Is essential for aerobic growth on D- malate as the sole carbon source. But is not required for anaerobic D-malate utilization, although DmlA is expressed and active in those conditions. Appears to be not able to use L- tartrate as a substrate for dehydrogenation instead of D-malate
C1_01375	155864.EDL933_2767	8.5e-173	612.8	Escherichia	dmlR	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006082,GO:0006108,GO:0006355,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043436,GO:0043565,GO:0043648,GO:0044237,GO:0044281,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141		ko:K16135,ko:K21742					ko00000,ko03000				Bacteria	1MVJ7@1224,1RMNJ@1236,3XPY5@561,COG0583@1,COG0583@2	NA|NA|NA	K	transcriptional regulator
C1_01376	469008.B21_01756	1.6e-109	402.1	Escherichia	leuE	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015175,GO:0015179,GO:0015190,GO:0015318,GO:0015658,GO:0015711,GO:0015803,GO:0015804,GO:0015807,GO:0015820,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0042968,GO:0042970,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903825,GO:1905039		ko:K11250					ko00000,ko02000	2.A.76.1.5			Bacteria	1RA1G@1224,1RSYH@1236,3XPDM@561,COG1280@1,COG1280@2	NA|NA|NA	E	efflux protein
C1_01377	155864.EDL933_2764	2.3e-65	254.6	Escherichia	yeaR												Bacteria	1RFYQ@1224,1S3XP@1236,3XPKQ@561,COG3615@1,COG3615@2	NA|NA|NA	P	Domain of unknown function (DUF1971)
C1_01378	155864.EDL933_2763	1.7e-16	91.3	Escherichia	yoaG												Bacteria	1RJTW@1224,1SAQ5@1236,2BFDU@1,32979@2,3XQ3U@561	NA|NA|NA	S	Domain of unknown function (DUF1869)
C1_01379	155864.EDL933_3566	2.3e-72	278.1	Escherichia				ko:K07491					ko00000				Bacteria	1RDD7@1224,1S4R2@1236,3XRGX@561,COG1943@1,COG1943@2	NA|NA|NA	L	Transposase IS200 like
C1_01380	155864.EDL933_3565	4.4e-211	740.3	Escherichia	Z012_11195			ko:K07496					ko00000				Bacteria	1MUU0@1224,1RS1J@1236,3XPN5@561,COG0675@1,COG0675@2	NA|NA|NA	L	Transposase
C1_01381	155864.EDL933_2762	4e-37	160.2	Escherichia	yeaQ												Bacteria	1N72W@1224,1S8YP@1236,3XR58@561,COG2261@1,COG2261@2	NA|NA|NA	S	Transglycosylase associated protein
C1_01382	481805.EcolC_1839	3.8e-190	670.6	Escherichia	yeaP	GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0052621	2.7.7.65	ko:K13069			R08057		ko00000,ko01000				Bacteria	1MVSA@1224,1RP1K@1236,3XMBK@561,COG2199@1,COG2199@2,COG2203@1,COG2203@2	NA|NA|NA	T	diguanylate cyclase activity
C1_01383	481805.EcolC_1840	5.6e-42	176.4	Escherichia	yoaF			ko:K09712					ko00000				Bacteria	1N8JF@1224,1SCRE@1236,3XPZN@561,COG3042@1,COG3042@2	NA|NA|NA	S	Domain of unknown function (DUF333)
C1_01384	469008.B21_01749	8.1e-60	236.1	Escherichia	yeaO												Bacteria	1MZ7H@1224,1S9PQ@1236,3XPSR@561,COG3189@1,COG3189@2	NA|NA|NA	S	Protein of unknown function, DUF488
C1_01385	155864.EDL933_2755	4.1e-212	743.8	Escherichia	yeaN	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0042221,GO:0044464,GO:0046677,GO:0050896,GO:0071944		ko:K03449					ko00000,ko02000	2.A.1.17			Bacteria	1MXGT@1224,1RNWA@1236,3XMU7@561,COG2807@1,COG2807@2	NA|NA|NA	P	response to antibiotic
C1_01386	316407.85675122	1.3e-153	548.9	Escherichia	yeaM	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006089,GO:0006355,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009438,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019172,GO:0019219,GO:0019222,GO:0019243,GO:0019249,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0044237,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0045892,GO:0045934,GO:0046185,GO:0046394,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051596,GO:0060255,GO:0061727,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:0097159,GO:1901363,GO:1901575,GO:1901576,GO:1901615,GO:1901617,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141											Bacteria	1NETZ@1224,1RQ20@1236,3XQW1@561,COG2207@1,COG2207@2	NA|NA|NA	K	Negatively regulates expression of the nimT operon and its own expression. Acts by binding to the nimR-nimT intergenic region
C1_01387	198214.SF1435	1.5e-69	268.9	Gammaproteobacteria	yeaL	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1RA7I@1224,1S2D6@1236,COG2707@1,COG2707@2	NA|NA|NA	S	UPF0756 membrane protein
C1_01388	469008.B21_01744	5.6e-86	323.6	Escherichia	yeaK	GO:0002161,GO:0002196,GO:0003674,GO:0003824,GO:0006139,GO:0006399,GO:0006417,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016787,GO:0016788,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0045727,GO:0045903,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:2000112		ko:K03976,ko:K19055					ko00000,ko01000,ko03016				Bacteria	1R9YR@1224,1S27F@1236,3XMST@561,COG2606@1,COG2606@2	NA|NA|NA	S	Ser-tRNA(Ala) hydrolase activity
C1_01389	316407.85675119	2.9e-279	967.2	Escherichia	yeaJ	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0032879,GO:0040012,GO:0040013,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051270,GO:0051271,GO:0065007,GO:0071944,GO:1902021,GO:1902201,GO:2000145,GO:2000146	2.7.7.65	ko:K18968	ko02026,map02026				ko00000,ko00001,ko01000,ko02000	9.B.34.1.2			Bacteria	1P3SE@1224,1SSZV@1236,3XMW0@561,COG2199@1,COG2199@2	NA|NA|NA	T	negative regulation of cell motility
C1_01390	316407.1736413	1.2e-269	935.3	Escherichia	yeaI	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0032879,GO:0040012,GO:0040013,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051270,GO:0051271,GO:0065007,GO:0071944,GO:1902021,GO:1902201,GO:2000145,GO:2000146										iAPECO1_1312.APECO1_853	Bacteria	1RGCV@1224,1T2TE@1236,3XPCJ@561,COG2199@1,COG2199@2	NA|NA|NA	T	negative regulation of cell motility
C1_01391	155864.EDL933_2748	1.7e-232	811.6	Escherichia	yhbH			ko:K09786					ko00000				Bacteria	1MWQM@1224,1RQWC@1236,3XPFD@561,COG2718@1,COG2718@2	NA|NA|NA	S	Belongs to the UPF0229 family
C1_01392	1440052.EAKF1_ch4267c	0.0	1293.9	Escherichia	prkA	GO:0003674,GO:0003824,GO:0004672,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006995,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036211,GO:0042594,GO:0043170,GO:0043412,GO:0043562,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0140096,GO:1901564		ko:K07180					ko00000				Bacteria	1MVW7@1224,1RNFJ@1236,3XNP5@561,COG2766@1,COG2766@2	NA|NA|NA	T	cellular response to nitrogen levels
C1_01393	198214.SF1441	9.3e-146	522.7	Gammaproteobacteria	mipA	GO:0000270,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0030203,GO:0030312,GO:0030313,GO:0030674,GO:0031975,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044462,GO:0044464,GO:0060090,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576		ko:K07274					ko00000,ko02000	9.B.99.1			Bacteria	1MWQN@1224,1RQTM@1236,COG3713@1,COG3713@2	NA|NA|NA	M	MltA-interacting protein
C1_01394	316407.85675118	5.1e-156	557.0	Escherichia	yeaE	GO:0003674,GO:0003824,GO:0006081,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016491,GO:0042180,GO:0042182,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046185,GO:0051596,GO:0055114,GO:0071704,GO:1901575	1.1.1.21	ko:K00011	ko00040,ko00051,ko00052,ko00561,ko00790,ko01100,map00040,map00051,map00052,map00561,map00790,map01100		R01036,R01041,R01093,R01095,R01431,R01758,R01759,R01787,R02531,R02577,R04285,R11764	RC00099,RC00108,RC00133,RC00205,RC00670	ko00000,ko00001,ko01000			iAF1260.b1781,iB21_1397.B21_01738,iBWG_1329.BWG_1594,iECBD_1354.ECBD_1863,iECB_1328.ECB_01750,iECDH10B_1368.ECDH10B_1919,iECDH1ME8569_1439.ECDH1ME8569_1725,iECD_1391.ECD_01750,iEcDH1_1363.EcDH1_1861,iEcHS_1320.EcHS_A1866,iEcolC_1368.EcolC_1851,iJO1366.b1781,iY75_1357.Y75_RS09335	Bacteria	1MUH2@1224,1RMK5@1236,3XNVM@561,COG0656@1,COG0656@2	NA|NA|NA	S	methylglyoxal catabolic process
C1_01395	198214.SF1443	1.2e-168	599.0	Gammaproteobacteria	yeaD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716	4.2.1.9,5.1.3.15	ko:K01687,ko:K01792	ko00010,ko00290,ko00770,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00010,map00290,map00770,map01100,map01110,map01120,map01130,map01210,map01230	M00019,M00570	R01209,R02739,R04441,R05070	RC00468,RC00563,RC01714	ko00000,ko00001,ko00002,ko01000				Bacteria	1Q7VN@1224,1RQK0@1236,COG0676@1,COG0676@2	NA|NA|NA	G	Belongs to the glucose-6-phosphate 1-epimerase family
C1_01396	155864.EDL933_2743	8.5e-187	659.4	Escherichia	gapA	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0042866,GO:0043436,GO:0043891,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576	1.2.1.12,1.2.1.72	ko:K00134,ko:K03472	ko00010,ko00710,ko00750,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map00750,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00124,M00165,M00166,M00308,M00552	R01061,R01825	RC00149,RC00242	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147			iAPECO1_1312.APECO1_847,iJR904.b1416,iJR904.b1417,iPC815.YPO2157,iUTI89_1310.UTI89_C1975,ic_1306.c2184	Bacteria	1MU93@1224,1RMBM@1236,3XNHT@561,COG0057@1,COG0057@2	NA|NA|NA	F	Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG
C1_01397	155864.EDL933_2742	3.2e-79	300.8	Escherichia	msrB	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016491,GO:0016667,GO:0016671,GO:0019538,GO:0030091,GO:0033743,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:1901564	1.8.4.12	ko:K07305					ko00000,ko01000			iAF1260.b1778,iB21_1397.B21_01735,iBWG_1329.BWG_1591,iE2348C_1286.E2348C_1905,iEC042_1314.EC042_1944,iEC55989_1330.EC55989_1947,iECBD_1354.ECBD_1866,iECB_1328.ECB_01747,iECDH10B_1368.ECDH10B_1916,iECDH1ME8569_1439.ECDH1ME8569_1722,iECD_1391.ECD_01747,iECH74115_1262.ECH74115_2502,iECIAI39_1322.ECIAI39_1275,iECNA114_1301.ECNA114_1824,iECO103_1326.ECO103_1964,iECP_1309.ECP_1726,iECSE_1348.ECSE_1949,iECSF_1327.ECSF_1639,iECSP_1301.ECSP_2350,iECUMN_1333.ECUMN_2067,iECW_1372.ECW_m1947,iECs_1301.ECs2487,iEKO11_1354.EKO11_1997,iETEC_1333.ETEC_1810,iEcDH1_1363.EcDH1_1864,iEcE24377_1341.EcE24377A_2002,iEcSMS35_1347.EcSMS35_1413,iG2583_1286.G2583_2225,iJO1366.b1778,iLF82_1304.LF82_1402,iNRG857_1313.NRG857_08905,iPC815.YPO2158,iSSON_1240.SSON_1385,iWFL_1372.ECW_m1947,iY75_1357.Y75_RS09320,iYL1228.KPN_01198,iZ_1308.Z2817	Bacteria	1RGWC@1224,1S5WI@1236,3XM35@561,COG0229@1,COG0229@2	NA|NA|NA	O	peptide-methionine (R)-S-oxide reductase activity
C1_01398	198214.SF1446	3.7e-44	183.7	Gammaproteobacteria	yeaC			ko:K09916					ko00000				Bacteria	1N6T3@1224,1SCFV@1236,COG3139@1,COG3139@2	NA|NA|NA	S	protein conserved in bacteria
C1_01399	155864.EDL933_2740	1.3e-209	735.3	Escherichia	gutB		1.1.1.1,1.1.1.14	ko:K00001,ko:K00008	ko00010,ko00040,ko00051,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00040,map00051,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	M00014	R00623,R00754,R00875,R01896,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00085,RC00087,RC00088,RC00099,RC00102,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko00002,ko01000				Bacteria	1R73D@1224,1RQIW@1236,3XRI5@561,COG1063@1,COG1063@2	NA|NA|NA	C	zinc ion binding
C1_01400	481805.EcolC_1857	8e-252	875.9	Escherichia	ydjK	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K08369					ko00000,ko02000	2.A.1			Bacteria	1QUCH@1224,1T1T9@1236,3XR4D@561,COG2271@1,COG2271@2	NA|NA|NA	P	transmembrane transporter activity
C1_01401	481805.EcolC_1858	2.1e-199	701.4	Escherichia	ydjJ		1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000				Bacteria	1MV9A@1224,1RMNY@1236,3XPEF@561,COG1063@1,COG1063@2	NA|NA|NA	E	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate
C1_01402	316407.1742884	1e-156	559.3	Escherichia	ydjI											iAPECO1_1312.APECO1_842,iB21_1397.B21_01730,iECBD_1354.ECBD_1871,iECB_1328.ECB_01742,iECD_1391.ECD_01742,iECH74115_1262.ECH74115_2497,iECOK1_1307.ECOK1_1892,iECS88_1305.ECS88_1825,iECSP_1301.ECSP_2345,iECs_1301.ECs2482,iG2583_1286.G2583_2220,iUMN146_1321.UM146_08280,iUTI89_1310.UTI89_C1969,iZ_1308.Z2811	Bacteria	1Q2AF@1224,1RSPE@1236,3XM6U@561,COG0191@1,COG0191@2	NA|NA|NA	G	aldehyde-lyase activity
C1_01403	316407.85675114	6.7e-173	613.2	Escherichia	ydjH		2.7.1.15	ko:K00852	ko00030,map00030		R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000				Bacteria	1MV6I@1224,1RSHQ@1236,3XQ2Z@561,COG0524@1,COG0524@2	NA|NA|NA	G	phosphotransferase activity, alcohol group as acceptor
C1_01404	316407.1742882	7.1e-186	656.4	Escherichia	ydjG	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0019170,GO:0055114		ko:K18471	ko00640,map00640		R10718	RC00739	ko00000,ko00001,ko01000				Bacteria	1MVEH@1224,1RZSW@1236,3XRJ3@561,COG0667@1,COG0667@2	NA|NA|NA	C	Catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It is not known if this activity has physiological significance. Cannot use NADPH as a cosubstrate. Seems to play some role in intestinal colonization
C1_01405	316407.1742881	5.8e-135	486.9	Gammaproteobacteria	ydjF												Bacteria	1R7X3@1224,1S09E@1236,COG1349@1,COG1349@2	NA|NA|NA	K	transcriptional regulator
C1_01406	316407.1742880	9.4e-245	852.4	Gammaproteobacteria	ydjE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K08369					ko00000,ko02000	2.A.1			Bacteria	1QUAJ@1224,1S18U@1236,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
C1_01407	155864.EDL933_2729	7.3e-123	446.4	Escherichia	pncA	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008936,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0018130,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0030145,GO:0034641,GO:0034654,GO:0043094,GO:0043167,GO:0043169,GO:0043173,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.11.1,3.5.1.19	ko:K08281,ko:K12132	ko00760,ko01100,map00760,map01100		R01268	RC00100	ko00000,ko00001,ko01000,ko01001			iE2348C_1286.E2348C_1895,iECs_1301.ECs2475,iZ_1308.Z2802	Bacteria	1MUGW@1224,1RZBF@1236,3XNAR@561,COG1335@1,COG1335@2	NA|NA|NA	Q	nicotinamidase activity
C1_01408	316407.1742878	3.4e-191	674.1	Escherichia	ansA	GO:0003674,GO:0003824,GO:0004067,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006528,GO:0006530,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009066,GO:0009068,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0032787,GO:0033345,GO:0034641,GO:0042802,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:0072329,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110		R00485	RC00010,RC02798	ko00000,ko00001,ko01000			iECO103_1326.ECO103_1961,iSF_1195.SF1456,iS_1188.S1571,iYL1228.KPN_01203	Bacteria	1MWIR@1224,1RMUB@1236,3XP19@561,COG0252@1,COG0252@2	NA|NA|NA	EJ	asparagine catabolic process via L-aspartate
C1_01409	481805.EcolC_1866	0.0	1209.9	Escherichia	sppA	GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006465,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0010467,GO:0016020,GO:0016021,GO:0016485,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0051604,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564		ko:K04773,ko:K04774,ko:K21511					ko00000,ko01000,ko01002				Bacteria	1MUXE@1224,1RNYW@1236,3XP8X@561,COG0616@1,COG0616@2	NA|NA|NA	OU	signal peptide peptidase
C1_01410	155864.EDL933_2725	2.6e-100	371.3	Escherichia	ydjA	GO:0000166,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0010181,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0097159,GO:0097367,GO:1901265,GO:1901363											Bacteria	1PKUV@1224,1RNQG@1236,3XNE4@561,COG0778@1,COG0778@2	NA|NA|NA	C	FMN binding
C1_01411	198214.SF1459	3.3e-197	694.1	Gammaproteobacteria	selD	GO:0000287,GO:0001887,GO:0003674,GO:0003824,GO:0004756,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009451,GO:0009987,GO:0010467,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016781,GO:0019752,GO:0034470,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0070329,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100		R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016			iPC815.YPO2164,iSFV_1184.SFV_1453,iSF_1195.SF1459,iSFxv_1172.SFxv_1645,iS_1188.S1574	Bacteria	1MWFG@1224,1RQ5Q@1236,COG0709@1,COG0709@2	NA|NA|NA	F	Synthesizes selenophosphate from selenide and ATP
C1_01412	198214.SF1460	0.0	1310.0	Gammaproteobacteria	topB	GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0007049,GO:0007059,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0022402,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0051304,GO:0071704,GO:0090304,GO:0140097,GO:1901360	5.99.1.2	ko:K03169					ko00000,ko01000,ko03032				Bacteria	1MUFZ@1224,1RN4X@1236,COG0550@1,COG0550@2	NA|NA|NA	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C1_01413	316407.85675112	2.5e-18	97.4	Gammaproteobacteria	ynjI	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1R9IQ@1224,1S1XT@1236,2BUS6@1,32Q3H@2	NA|NA|NA	S	Protein of unknown function (DUF1266)
C1_01414	198214.SF1461	1.8e-172	611.7	Gammaproteobacteria	ynjI	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1R9IQ@1224,1S1XT@1236,2BUS6@1,32Q3H@2	NA|NA|NA	S	Protein of unknown function (DUF1266)
C1_01415	155864.EDL933_2721	2.4e-253	880.9	Escherichia	gdhA	GO:0003674,GO:0003824,GO:0004353,GO:0004354,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.4	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100		R00248	RC00006,RC02799	ko00000,ko00001,ko01000			iECH74115_1262.ECH74115_2481,iECSP_1301.ECSP_2329,iECs_1301.ECs2467,iG2583_1286.G2583_2207,iPC815.YPO3971,iSDY_1059.SDY_1514,iYL1228.KPN_01210,iZ_1308.Z2793	Bacteria	1MUMF@1224,1RPUZ@1236,3XMVU@561,COG0334@1,COG0334@2	NA|NA|NA	E	Belongs to the Glu Leu Phe Val dehydrogenases family
C1_01416	198214.SF1465	2.6e-45	187.6	Gammaproteobacteria	ynjH												Bacteria	1NB7M@1224,1SCHX@1236,2E3JA@1,32YHQ@2	NA|NA|NA	S	Protein of unknown function (DUF1496)
C1_01417	198214.SF1466	4.7e-67	260.4	Gammaproteobacteria	nudG	GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	3.6.1.55,3.6.1.65	ko:K03574,ko:K08320					ko00000,ko01000,ko03400			iE2348C_1286.E2348C_1887,iECP_1309.ECP_1705,iLF82_1304.LF82_1533,iNRG857_1313.NRG857_08815,iPC815.YPO2167,iSDY_1059.SDY_0129,iSSON_1240.SSON_1397	Bacteria	1RCZM@1224,1S67W@1236,COG0494@1,COG0494@2	NA|NA|NA	L	belongs to the nudix hydrolase family
C1_01418	316407.85675110	9e-110	402.9	Escherichia	ynjF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100		R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000				Bacteria	1RD5Y@1224,1RZ4Q@1236,3XNG1@561,COG0558@1,COG0558@2	NA|NA|NA	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C1_01419	481805.EcolC_1875	5.5e-258	896.3	Escherichia	ynjE	GO:0003674,GO:0003824,GO:0016740,GO:0016782,GO:0016783	2.8.1.11	ko:K21028	ko04122,map04122		R07461		ko00000,ko00001,ko01000				Bacteria	1MW4B@1224,1RQX7@1236,3XPET@561,COG2897@1,COG2897@2	NA|NA|NA	M	thiosulfate sulfurtransferase activity
C1_01420	198214.SF1469	1.6e-112	412.1	Gammaproteobacteria	ynjD			ko:K05779		M00192			ko00000,ko00002,ko02000				Bacteria	1RA88@1224,1S207@1236,COG4136@1,COG4136@2	NA|NA|NA	S	ABC transporter
C1_01421	481805.EcolC_1877	2.6e-275	954.1	Escherichia	ynjC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02053,ko:K05778	ko02024,map02024	M00192,M00193			ko00000,ko00001,ko00002,ko02000	3.A.1.11			Bacteria	1MV6R@1224,1RR4B@1236,3XNN0@561,COG4135@1,COG4135@2	NA|NA|NA	P	ABC transporter permease
C1_01422	316407.85675106	3.3e-222	777.3	Escherichia	ynjB			ko:K02055,ko:K05777	ko02024,map02024	M00192,M00193			ko00000,ko00001,ko00002,ko02000	3.A.1.11			Bacteria	1MWJ7@1224,1RQ0I@1236,3XNDY@561,COG4134@1,COG4134@2	NA|NA|NA	S	Bacterial extracellular solute-binding protein
C1_01423	155864.EDL933_2713	6.3e-99	366.7	Escherichia	ynjA			ko:K07486					ko00000				Bacteria	1RC52@1224,1S2A0@1236,3XQ7H@561,COG2128@1,COG2128@2	NA|NA|NA	S	peroxiredoxin activity
C1_01424	469008.B21_01709	1.2e-123	449.1	Escherichia	ydjZ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1RDZ2@1224,1RYPP@1236,3XPQ3@561,COG0398@1,COG0398@2	NA|NA|NA	S	SNARE associated Golgi protein
C1_01425	481805.EcolC_1881	1.3e-125	455.7	Escherichia	ydjY	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Bacteria	1NZYD@1224,1S1F4@1236,28JAM@1,2Z95F@2,3XNDZ@561	NA|NA|NA		
C1_01426	199310.c2151	5.2e-122	443.7	Escherichia	ydjX	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1MVF3@1224,1RSK1@1236,3XMYD@561,COG0398@1,COG0398@2	NA|NA|NA	S	SNARE associated Golgi protein
C1_01427	316407.1742858	2e-157	561.6	Escherichia	xthA	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008853,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	3.1.11.2	ko:K01142	ko03410,map03410				ko00000,ko00001,ko01000,ko03400				Bacteria	1MVII@1224,1RN4H@1236,3XPFE@561,COG0708@1,COG0708@2	NA|NA|NA	L	Major apurinic-apyrimidinic endonuclease of E.coli. It removes the damaged DNA at cytosines and guanines by cleaving on the 3'-side of the AP site by a beta-elimination reaction. It exhibits 3'-5'-exonuclease, 3'-phosphomonoesterase, 3'-repair diesterase and ribonuclease H activities
C1_01428	316407.1742857	2.5e-236	824.3	Escherichia	argD	GO:0003674,GO:0003824,GO:0003992,GO:0005488,GO:0005515,GO:0006082,GO:0006105,GO:0006520,GO:0006525,GO:0006526,GO:0006527,GO:0006553,GO:0006591,GO:0006593,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009016,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009065,GO:0009066,GO:0009067,GO:0009084,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016769,GO:0017144,GO:0019545,GO:0019752,GO:0019842,GO:0030170,GO:0033359,GO:0036094,GO:0042450,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043825,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0046451,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	2.6.1.11,2.6.1.17,2.6.1.81	ko:K00821,ko:K00840	ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04217,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007			iAPECO1_1312.APECO1_817,iEC55989_1330.EC55989_1916,iECABU_c1320.ECABU_c20050,iECED1_1282.ECED1_1950,iECOK1_1307.ECOK1_1868,iECP_1309.ECP_1694,iECS88_1305.ECS88_1800,iEcSMS35_1347.EcSMS35_1443,iSFV_1184.SFV_3365,iSF_1195.SF3378,iSFxv_1172.SFxv_3689,iS_1188.S4385,iUMN146_1321.UM146_08405,iUTI89_1310.UTI89_C1943,ic_1306.c2148	Bacteria	1MV3C@1224,1RMV1@1236,3XNAC@561,COG4992@1,COG4992@2	NA|NA|NA	E	Catalyzes the transamination of N(2)-succinylornithine and alpha-ketoglutarate into N(2)-succinylglutamate semialdehyde and glutamate. Can also act as an acetylornithine aminotransferase
C1_01429	155864.EDL933_2706	3.8e-198	697.2	Escherichia	astA		1.2.1.71,2.3.1.109	ko:K00673,ko:K06447	ko00330,ko01100,map00330,map01100		R00832,R05049	RC00004,RC00064,RC00080	ko00000,ko00001,ko01000			iE2348C_1286.E2348C_1875	Bacteria	1MWHC@1224,1RMXG@1236,3XMJ6@561,COG3138@1,COG3138@2	NA|NA|NA	E	Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine
C1_01430	469008.B21_01703	1.5e-280	971.5	Escherichia	astD	GO:0003674,GO:0003824,GO:0004029,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114	1.2.1.71	ko:K06447	ko00330,ko01100,map00330,map01100		R05049	RC00080	ko00000,ko00001,ko01000			iECABU_c1320.ECABU_c20030,iEcHS_1320.EcHS_A1829,ic_1306.c2146	Bacteria	1MV2I@1224,1RPQW@1236,3XMV0@561,COG1012@1,COG1012@2	NA|NA|NA	C	Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate
C1_01431	469008.B21_01702	3.8e-254	883.6	Escherichia	astB	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006807,GO:0008150,GO:0008152,GO:0009015,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016813,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	3.5.3.23	ko:K01484	ko00330,ko01100,map00330,map01100		R04189	RC00024	ko00000,ko00001,ko01000			iECH74115_1262.ECH74115_2463,iECSP_1301.ECSP_2313,iECs_1301.ECs2451,iG2583_1286.G2583_2191	Bacteria	1MUJV@1224,1RNSS@1236,3XMGR@561,COG3724@1,COG3724@2	NA|NA|NA	E	Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2)
C1_01432	316407.85675099	3.6e-190	670.6	Escherichia	astE	GO:0003674,GO:0003824,GO:0009017,GO:0016787,GO:0016810,GO:0016811	3.5.1.96	ko:K05526	ko00330,ko01100,map00330,map01100		R00411	RC00064,RC00090	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_813,iECABU_c1320.ECABU_c20010,iECED1_1282.ECED1_1946,iECOK1_1307.ECOK1_1864,iECS88_1305.ECS88_1796,iUMN146_1321.UM146_08430,iUTI89_1310.UTI89_C1939,ic_1306.c2144	Bacteria	1MW1T@1224,1RQPG@1236,3XNVD@561,COG2988@1,COG2988@2	NA|NA|NA	E	Belongs to the AspA AstE family. Succinylglutamate desuccinylase subfamily
C1_01433	155864.EDL933_2702	5.2e-81	307.0	Escherichia	spy	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006457,GO:0008150,GO:0009987,GO:0010033,GO:0014070,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0044464,GO:0050896,GO:0051082,GO:0061077,GO:1990507		ko:K06006					ko00000,ko03110				Bacteria	1RBDH@1224,1S2DT@1236,3XPA1@561,COG3678@1,COG3678@2	NA|NA|NA	NPTU	An ATP-independent periplasmic chaperone, decreases protein aggregation and helps protein refolding. Binds substrate over a large region
C1_01434	316407.1742847	6.6e-107	393.3	Escherichia	ves			ko:K09975					ko00000				Bacteria	1MXSD@1224,1RMHD@1236,3XP6F@561,COG3758@1,COG3758@2	NA|NA|NA	S	Belongs to the Ves family
C1_01435	316407.85675098	9.3e-169	599.4	Escherichia	cho	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006289,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009380,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016787,GO:0016788,GO:0030312,GO:0031668,GO:0032991,GO:0033554,GO:0033683,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1902494,GO:1905347,GO:1905348,GO:1990391	2.7.7.7	ko:K02342,ko:K03703,ko:K05984	ko00230,ko00240,ko01100,ko03030,ko03420,ko03430,ko03440,map00230,map00240,map01100,map03030,map03420,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Bacteria	1QU1K@1224,1RMJM@1236,3XNBR@561,COG0322@1,COG0322@2	NA|NA|NA	L	When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair
C1_01436	199310.c2139	1.1e-152	545.8	Escherichia	nadE	GO:0003674,GO:0003824,GO:0003952,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0016884,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0033554,GO:0034355,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043094,GO:0043173,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000			iECSE_1348.ECSE_1910,iECW_1372.ECW_m1909,iEKO11_1354.EKO11_2035,iETEC_1333.ETEC_1772,iEcE24377_1341.EcE24377A_1961,iSFV_1184.SFV_1480,iSF_1195.SF1486,iSFxv_1172.SFxv_1676,iSSON_1240.SSON_1418,iS_1188.S1603,iWFL_1372.ECW_m1909	Bacteria	1QHZ4@1224,1SZSC@1236,3XRM7@561,COG0171@1,COG0171@2	NA|NA|NA	F	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
C1_01437	155864.EDL933_2698	6.3e-57	226.5	Escherichia	osmE	GO:0006950,GO:0006970,GO:0008150,GO:0009628,GO:0050896		ko:K04064,ko:K06186					ko00000,ko02000	1.B.33.1			Bacteria	1RD8V@1224,1S48R@1236,3XPRB@561,COG2913@1,COG2913@2	NA|NA|NA	M	response to osmotic stress
C1_01438	1440052.EAKF1_ch4313	1.8e-50	204.9	Escherichia	chbB	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044424,GO:0044444,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0090563,GO:0090566,GO:1901264,GO:1902815	2.7.1.196,2.7.1.205	ko:K02760	ko00500,ko02060,map00500,map02060	M00275	R11170,R11172	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.3.2		iSbBS512_1146.SbBS512_E1982	Bacteria	1RITP@1224,1S632@1236,3XR15@561,COG1440@1,COG1440@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ChbABC PTS system is involved in the transport of the chitin disaccharide N,N'-diacetylchitobiose (GlcNAc2)
C1_01439	316407.85675097	7.7e-239	832.8	Escherichia	celB	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0016020,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071944,GO:1901264,GO:1902815		ko:K02761	ko00500,ko02060,map00500,map02060	M00275	R11170,R11172	RC00017,RC03206	ko00000,ko00001,ko00002,ko02000	4.A.3.2		iECABU_c1320.ECABU_c19930	Bacteria	1PF2A@1224,1SYHD@1236,3XMPB@561,COG1455@1,COG1455@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
C1_01440	198214.SF1490	3.3e-53	214.2	Gammaproteobacteria	celC	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0009987,GO:0015144,GO:0016043,GO:0016740,GO:0016772,GO:0016773,GO:0022607,GO:0022804,GO:0022857,GO:0034219,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0071702,GO:0071840,GO:0090563,GO:0090566,GO:1901264,GO:1902815	2.7.1.196,2.7.1.205	ko:K02759	ko00500,ko02060,map00500,map02060	M00275	R11170,R11172	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.3.2		iECUMN_1333.ECUMN_2025	Bacteria	1RI0T@1224,1S75F@1236,COG1447@1,COG1447@2	NA|NA|NA	G	Phosphotransferase System
C1_01441	155864.EDL933_2694	3.3e-155	554.3	Escherichia	chbR	GO:0001047,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	2.1.1.63,3.1.31.1,3.2.2.21	ko:K01174,ko:K03490,ko:K10778,ko:K13529,ko:K15051	ko03410,map03410				ko00000,ko00001,ko01000,ko03000,ko03400				Bacteria	1MXV1@1224,1RQRD@1236,3XMCY@561,COG1917@1,COG1917@2,COG2169@1,COG2169@2	NA|NA|NA	K	Dual-function repressor activator of the chbBCARFG operon. In the absence of the inducing sugar chitobiose, together with NagC, represses the chbBCARFG operon for the uptake and metabolism of chitobiose. In association with Crp, and probably in the presence of chitobiose 6-phosphate, induces the transcription of the chbBCARFG operon
C1_01442	481805.EcolC_1898	1.8e-259	901.4	Escherichia	chbF	GO:0003674,GO:0003824,GO:0004553,GO:0005488,GO:0005515,GO:0008422,GO:0008706,GO:0015926,GO:0016787,GO:0016798,GO:0042802	3.2.1.86	ko:K01222	ko00010,ko00500,map00010,map00500		R00839,R05133,R05134	RC00049,RC00171,RC00714	ko00000,ko00001,ko01000		GT4	iECH74115_1262.ECH74115_2452,iECSP_1301.ECSP_2302	Bacteria	1NI6G@1224,1RPG8@1236,3XP95@561,COG1486@1,COG1486@2	NA|NA|NA	G	methyl beta-D-glucoside 6-phosphate glucohydrolase activity
C1_01443	155864.EDL933_2692	7.3e-138	496.5	Escherichia	chbG	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009056,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0036311,GO:0052777,GO:0052778,GO:0052779,GO:0052782,GO:0071704,GO:1901135,GO:1901136,GO:1901575	2.7.1.196,2.7.1.205,3.5.1.105	ko:K02759,ko:K03478	ko00500,ko02060,map00500,map02060	M00275	R11170,R11172	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.3.2			Bacteria	1MX3P@1224,1RRC4@1236,3XPHH@561,COG3394@1,COG3394@2	NA|NA|NA	G	Involved in the degradation of chitin. ChbG is essential for growth on the acetylated chitooligosaccharides chitobiose and chitotriose but is dispensable for growth on cellobiose and chitosan dimer, the deacetylated form of chitobiose. Deacetylation of chitobiose-6-P and chitotriose-6-P is necessary for both the activation of the chb promoter by the regulatory protein ChbR and the hydrolysis of phosphorylated beta-glucosides by the phospho- beta-glucosidase ChbF. Catalyzes the removal of only one acetyl group from chitobiose-6-P to yield monoacetylchitobiose-6-P, the inducer of ChbR and the substrate of ChbF
C1_01444	316407.1742829	0.0	1514.2	Escherichia	katE	GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006970,GO:0006972,GO:0006974,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009628,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0042221,GO:0042737,GO:0042743,GO:0042744,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044248,GO:0044424,GO:0044464,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070887,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1990748	1.11.1.6	ko:K03781	ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014	M00532	R00009,R00602,R02670	RC00034,RC00767,RC02141,RC02755	ko00000,ko00001,ko00002,ko01000			iECO26_1355.ECO26_2506	Bacteria	1MUXZ@1224,1RNE7@1236,3XM73@561,COG0753@1,COG0753@2	NA|NA|NA	P	serves to protect cells from the toxic effects of hydrogen peroxide
C1_01445	155864.EDL933_2690	1.8e-37	161.4	Escherichia	cedA	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0008150,GO:0050789,GO:0050794,GO:0051302,GO:0065007,GO:0097159,GO:1901363		ko:K15722					ko00000				Bacteria	1N1CP@1224,1S8XC@1236,2CFPH@1,32S26@2,3XPYW@561	NA|NA|NA	D	Activates the cell division inhibited by chromosomal DNA over-replication
C1_01446	198214.SF1498	4.9e-60	236.9	Gammaproteobacteria	ydjO												Bacteria	1NR3K@1224,1SMQV@1236,2EW0H@1,33PDX@2	NA|NA|NA		
C1_01447	316407.85675095	6.1e-53	213.4	Escherichia	ydjO												Bacteria	1NR3K@1224,1SMQV@1236,2EW0H@1,33PDX@2,3XR75@561	NA|NA|NA		
C1_01448	316407.1742823	8.1e-244	849.4	Escherichia	ydjN	GO:0000099,GO:0000101,GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006791,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015179,GO:0015184,GO:0015318,GO:0015711,GO:0015804,GO:0015807,GO:0015811,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0072348,GO:0072349,GO:0098656,GO:1901682,GO:1902475,GO:1903825,GO:1905039		ko:K06956					ko00000				Bacteria	1R3F8@1224,1RMHV@1236,3XNSQ@561,COG1823@1,COG1823@2	NA|NA|NA	U	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
C1_01449	198214.SF1502	2.6e-114	417.9	Gammaproteobacteria	ydjM	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0031668,GO:0033554,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:0071944		ko:K07038					ko00000				Bacteria	1Q0WR@1224,1RU1K@1236,COG1988@1,COG1988@2	NA|NA|NA	S	membrane-bound metal-dependent
C1_01450	155864.EDL933_2686	2.5e-118	431.4	Escherichia	yniC	GO:0000287,GO:0003674,GO:0003824,GO:0003850,GO:0004346,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0050084,GO:0050286,GO:0050308,GO:0050309	3.1.3.23	ko:K19270					ko00000,ko01000				Bacteria	1NF90@1224,1RNP8@1236,3XMXW@561,COG0637@1,COG0637@2	NA|NA|NA	S	this is a biologically important activity in vivo since it contributes to the elimination of this toxic compound and plays an important role in the resistance of E.coli to 2-deoxyglucose
C1_01451	469008.B21_01683	3.9e-93	347.4	Escherichia	yniB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1QISB@1224,1RP93@1236,28IJC@1,2Z8K9@2,3XNS4@561	NA|NA|NA	S	YniB-like protein
C1_01452	481805.EcolC_1907	1.8e-169	601.7	Escherichia	yniA	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0044237											Bacteria	1MVHX@1224,1RRC5@1236,3XP3H@561,COG3001@1,COG3001@2	NA|NA|NA	G	kinase activity
C1_01453	155864.EDL933_2683	3.8e-47	193.7	Escherichia	ydiZ	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716											Bacteria	1N13Q@1224,1S9QK@1236,2CY9P@1,32T3T@2,3XPVV@561	NA|NA|NA	S	endoribonuclease activity
C1_01454	155864.EDL933_2682	2.4e-167	594.7	Escherichia	pfkB	GO:0000287,GO:0003674,GO:0003824,GO:0003872,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008443,GO:0009024,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019200,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046835,GO:0046872,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0055086,GO:0061615,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.1.11,2.7.1.56	ko:K00882,ko:K16370	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00345	R00756,R02071,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_793,iUMNK88_1353.UMNK88_2713,iUTI89_1310.UTI89_C1916	Bacteria	1MVNW@1224,1RS3Y@1236,3XPFP@561,COG1105@1,COG1105@2	NA|NA|NA	F	Belongs to the carbohydrate kinase PfkB family
C1_01455	155864.EDL933_2681	8.3e-142	509.6	Escherichia	ydiY			ko:K07283					ko00000				Bacteria	1MWI4@1224,1RN4J@1236,3XP5N@561,COG3137@1,COG3137@2	NA|NA|NA	M	Protein of unknown function, DUF481
C1_01456	155864.EDL933_2680	5.6e-12	75.5	Escherichia													Bacteria	1NH6A@1224,1SH66@1236,2DSBC@1,33FD2@2,3XQ5X@561	NA|NA|NA		
C1_01457	155864.EDL933_2679	4.3e-236	823.9	Gammaproteobacteria				ko:K06867					ko00000				Bacteria	1QWC1@1224,1T2TD@1236,32YAJ@2,COG0666@1	NA|NA|NA	S	Corresponds to locus_tag
C1_01458	481805.EcolC_1913	0.0	1322.4	Escherichia	thrS	GO:0000166,GO:0000900,GO:0002161,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004812,GO:0004829,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006435,GO:0006446,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0017076,GO:0017148,GO:0019222,GO:0019538,GO:0019752,GO:0030371,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032553,GO:0032555,GO:0032559,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045182,GO:0045947,GO:0046483,GO:0046872,GO:0046914,GO:0048027,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090079,GO:0090304,GO:0097159,GO:0097367,GO:0106074,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112,GO:2000113	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iPC815.YPO2433,iSDY_1059.SDY_1814	Bacteria	1MUP2@1224,1RMYE@1236,3XNZY@561,COG0441@1,COG0441@2	NA|NA|NA	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C1_01459	199310.c2115	8.8e-72	276.2	Escherichia	infC	GO:0000049,GO:0001731,GO:0002181,GO:0002183,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006417,GO:0006446,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016020,GO:0016043,GO:0019222,GO:0019538,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032268,GO:0032270,GO:0032790,GO:0032984,GO:0032988,GO:0032991,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043254,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045727,GO:0045948,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065003,GO:0065007,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901193,GO:1901195,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:1904688,GO:1904690,GO:1990856,GO:1990904,GO:2000112,GO:2000765,GO:2000767		ko:K02520					ko00000,ko03012,ko03029				Bacteria	1RDD2@1224,1S4E6@1236,3XMQM@561,COG0290@1,COG0290@2	NA|NA|NA	J	binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C1_01460	1005994.GTGU_00408	2.7e-28	130.6	Gammaproteobacteria	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904		ko:K02916	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1N6V4@1224,1SCHI@1236,COG0291@1,COG0291@2	NA|NA|NA	J	Belongs to the bacterial ribosomal protein bL35 family
C1_01461	1006000.GKAS_03624	1.2e-53	215.7	Gammaproteobacteria	rplT	GO:0000027,GO:0000900,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0060255,GO:0065003,GO:0065007,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090079,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2000113,GO:2001141		ko:K02887	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1RGU2@1224,1S3P3@1236,COG0292@1,COG0292@2	NA|NA|NA	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C1_01462	316407.85675086	1.3e-184	652.1	Escherichia	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iJN746.PP_2469,iSSON_1240.SSON_1444,iYL1228.KPN_02176	Bacteria	1MVD7@1224,1RN22@1236,3XNIZ@561,COG0016@1,COG0016@2	NA|NA|NA	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C1_01463	316407.1742793	0.0	1569.3	Escherichia	pheT	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iG2583_1286.G2583_2160,iPC815.YPO2428	Bacteria	1MWKS@1224,1RMIH@1236,3XMDP@561,COG0072@1,COG0072@2,COG0073@1,COG0073@2	NA|NA|NA	J	phenylalanine-tRNA ligase activity
C1_01464	1006004.GBAG_1585	1.6e-48	198.4	Gammaproteobacteria	himA	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141		ko:K04764					ko00000,ko03032,ko03036,ko03400				Bacteria	1RH5Z@1224,1S61Z@1236,COG0776@1,COG0776@2	NA|NA|NA	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control
C1_01465	316407.1742791	2.1e-174	618.2	Escherichia	btuC	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0008150,GO:0015238,GO:0015399,GO:0015405,GO:0015420,GO:0015889,GO:0015893,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0032991,GO:0035461,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042802,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051180,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0090482,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351		ko:K06073	ko02010,map02010	M00241			ko00000,ko00001,ko00002,ko02000	3.A.1.13		iECO103_1326.ECO103_1855,iECO111_1330.ECO111_2181,iECO26_1355.ECO26_2440,iECW_1372.ECW_m1880,iEKO11_1354.EKO11_2064,iEcHS_1320.EcHS_A1791,iEcolC_1368.EcolC_1920,iWFL_1372.ECW_m1880	Bacteria	1R34H@1224,1RR7W@1236,3XNA9@561,COG4139@1,COG4139@2	NA|NA|NA	U	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane
C1_01466	155864.EDL933_2669	6.8e-101	373.2	Escherichia	btuE	GO:0003674,GO:0003824,GO:0004601,GO:0004602,GO:0005575,GO:0005623,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0033194,GO:0042221,GO:0042597,GO:0044464,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1990748	1.11.1.9	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918		R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000			iE2348C_1286.E2348C_1795,iEC55989_1330.EC55989_1878,iECABU_c1320.ECABU_c19650,iEcHS_1320.EcHS_A1790,iLF82_1304.LF82_0251,iNRG857_1313.NRG857_08570,iSFV_1184.SFV_1513,ic_1306.c2106	Bacteria	1RD1R@1224,1S425@1236,3XMQZ@561,COG0386@1,COG0386@2	NA|NA|NA	O	Non-specific peroxidase that can use thioredoxin or glutathione as a reducing agent
C1_01467	198214.SF1522	4e-136	490.7	Gammaproteobacteria	btuD	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008144,GO:0008150,GO:0015238,GO:0015399,GO:0015405,GO:0015420,GO:0015889,GO:0015893,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019898,GO:0022804,GO:0022857,GO:0030554,GO:0031224,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035461,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051180,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0090482,GO:0097159,GO:0097367,GO:0098533,GO:0098796,GO:0098797,GO:1901265,GO:1901363,GO:1902494,GO:1902495,GO:1904949,GO:1990351	3.6.3.33	ko:K06074	ko02010,map02010	M00241			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.13		iEC042_1314.EC042_1876,iEC55989_1330.EC55989_1877,iECIAI1_1343.ECIAI1_1765,iECIAI39_1322.ECIAI39_1344,iECSE_1348.ECSE_1834,iECUMN_1333.ECUMN_2000,iECW_1372.ECW_m1878,iEKO11_1354.EKO11_2066,iETEC_1333.ETEC_1742,iEcE24377_1341.EcE24377A_1928,iEcHS_1320.EcHS_A1789,iEcSMS35_1347.EcSMS35_1481,iEcolC_1368.EcolC_1922,iSDY_1059.SDY_1804,iSFV_1184.SFV_1514,iSF_1195.SF1522,iSFxv_1172.SFxv_1705,iSSON_1240.SSON_1449,iS_1188.S1639,iUMNK88_1353.UMNK88_2172,iWFL_1372.ECW_m1878	Bacteria	1NXS9@1224,1RRMD@1236,COG4138@1,COG4138@2	NA|NA|NA	P	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
C1_01468	155864.EDL933_2667	1.4e-86	325.5	Escherichia	nlpC		3.4.17.13	ko:K13694,ko:K13695,ko:K19303					ko00000,ko01000,ko01002,ko01011				Bacteria	1N0EE@1224,1RR2X@1236,3XMZY@561,COG0791@1,COG0791@2	NA|NA|NA	M	cysteine-type peptidase activity
C1_01469	316407.85675085	2.1e-134	485.0	Escherichia	ydiV	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006355,GO:0008081,GO:0008134,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016787,GO:0016788,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032879,GO:0040012,GO:0040013,GO:0042578,GO:0043392,GO:0043433,GO:0044092,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051090,GO:0051098,GO:0051100,GO:0051101,GO:0051171,GO:0051252,GO:0051270,GO:0051271,GO:0060255,GO:0065007,GO:0065009,GO:0071111,GO:0080090,GO:1902021,GO:1902201,GO:1903506,GO:2000112,GO:2000145,GO:2000146,GO:2000677,GO:2000678,GO:2001141	3.1.4.52	ko:K21086	ko02026,map02026				ko00000,ko00001,ko01000				Bacteria	1RAZ1@1224,1S1MP@1236,3XPNQ@561,COG2200@1,COG2200@2	NA|NA|NA	K	Upon overexpression acts as a novel anti-FlhC(2)FlhD(4) factor, decreasing its DNA-binding activity, able to negatively regulate expression of flagellar class II operons including FliC
C1_01470	316407.1742787	9.2e-275	952.2	Escherichia	ydiU			ko:K08997					ko00000				Bacteria	1MVK3@1224,1RNCS@1236,3XMWI@561,COG0397@1,COG0397@2	NA|NA|NA	S	Belongs to the UPF0061 (SELO) family
C1_01471	155864.EDL933_2664	3.4e-28	130.2	Bacteria	hemP												Bacteria	COG4256@1,COG4256@2	NA|NA|NA	P	Hemin uptake protein
C1_01472	199310.c2100	4.9e-201	706.8	Escherichia	aroH	GO:0003674,GO:0003824,GO:0003849,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019438,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000			iLF82_1304.LF82_0146,iNRG857_1313.NRG857_03335,iSbBS512_1146.SbBS512_E1908,iUTI89_1310.UTI89_C2934	Bacteria	1MU5Q@1224,1RMAA@1236,3XMMD@561,COG0722@1,COG0722@2	NA|NA|NA	E	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1_01473	155864.EDL933_2662	4.4e-152	543.9	Escherichia	ydiA	GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030234,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0065007,GO:0065009,GO:0098772	2.7.11.33,2.7.4.28	ko:K09773					ko00000,ko01000				Bacteria	1MUHU@1224,1RPHX@1236,3XN7K@561,COG1806@1,COG1806@2	NA|NA|NA	F	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation
C1_01474	316407.1742783	0.0	1557.0	Escherichia	ppsA	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008986,GO:0009058,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016781,GO:0019318,GO:0019319,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0071704,GO:1901576	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000			iEcE24377_1341.EcE24377A_1919,iYL1228.KPN_02160	Bacteria	1MU0R@1224,1RP3T@1236,3XMCT@561,COG0574@1,COG0574@2,COG1080@1,COG1080@2	NA|NA|NA	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate
C1_01475	481805.EcolC_1930	0.0	1109.0	Escherichia	fadK	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0015645,GO:0016020,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0031956,GO:0044464,GO:0071944		ko:K12507					ko00000,ko01000,ko01004			iECIAI1_1343.ECIAI1_1755	Bacteria	1MU6G@1224,1RMQ4@1236,3XMA2@561,COG0318@1,COG0318@2	NA|NA|NA	IQ	Catalyzes the esterification, concomitant with transport, of exogenous fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. Is maximally active on C6 0, C8 0 and C12 0 fatty acids, while has a low activity on C14-C18 chain length fatty acids. Is involved in the anaerobic beta-oxidative degradation of fatty acids, which allows anaerobic growth of E.coli on fatty acids as a sole carbon and energy source in the presence of nitrate or fumarate as a terminal electron acceptor. Can functionally replace FadD under anaerobic conditions
C1_01476	155864.EDL933_2658	2.8e-53	214.2	Escherichia	ydiT			ko:K03855					ko00000				Bacteria	1RHTX@1224,1S6ZD@1236,3XPQH@561,COG2440@1,COG2440@2	NA|NA|NA	C	Could be a 3Fe-4S cluster-containing protein
C1_01477	316407.1742778	5.6e-239	833.2	Escherichia	ydiS	GO:0006575,GO:0006577,GO:0006807,GO:0008150,GO:0008152,GO:0009437,GO:0009987,GO:0034641,GO:0044237,GO:0071704,GO:0097164,GO:1901564		ko:K00313					ko00000,ko01000				Bacteria	1MVU6@1224,1RNY5@1236,3XNRE@561,COG0644@1,COG0644@2	NA|NA|NA	C	electron transfer flavoprotein-quinone oxidoreductase ydiS
C1_01478	469008.B21_01656	3.3e-172	610.9	Escherichia	ydiR	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0019395,GO:0019752,GO:0022900,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575	1.3.8.1	ko:K00248,ko:K03522	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212		R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000,ko04147				Bacteria	1MUFI@1224,1RMK7@1236,3XM9A@561,COG2025@1,COG2025@2	NA|NA|NA	C	Electron transfer flavoprotein
C1_01479	316407.85675082	1.7e-134	485.3	Escherichia	ydiQ	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006575,GO:0006577,GO:0006579,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009437,GO:0009987,GO:0016491,GO:0022900,GO:0033554,GO:0034641,GO:0042219,GO:0042413,GO:0044237,GO:0044248,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0097164,GO:1901564,GO:1901565,GO:1901575		ko:K03521					ko00000				Bacteria	1MVH6@1224,1RZU6@1236,3XPHD@561,COG2086@1,COG2086@2	NA|NA|NA	C	Electron transfer flavoprotein
C1_01481	316407.1742775	5.3e-175	620.2	Escherichia	ydiP	GO:0003674,GO:0003700,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141											Bacteria	1MXC6@1224,1RZKV@1236,3XNJU@561,COG1917@1,COG1917@2,COG2207@1,COG2207@2	NA|NA|NA	K	Transcriptional regulator
C1_01482	155864.EDL933_2652	6.1e-221	773.1	Escherichia	ydiO	GO:0003674,GO:0003824,GO:0006066,GO:0008150,GO:0008152,GO:0009058,GO:0016491,GO:0016627,GO:0034308,GO:0034309,GO:0044281,GO:0044283,GO:0046165,GO:0052890,GO:0055114,GO:0071270,GO:0071271,GO:0071704,GO:1901576,GO:1901615,GO:1901617	1.3.8.13	ko:K08297					ko00000,ko01000				Bacteria	1MUDR@1224,1RMMJ@1236,3XP3K@561,COG1960@1,COG1960@2	NA|NA|NA	I	Acyl-coa dehydrogenase
C1_01483	155864.EDL933_2651	8.9e-303	1045.4	Escherichia	ydiF	GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008410,GO:0008775,GO:0009987,GO:0016043,GO:0016740,GO:0016782,GO:0019752,GO:0022607,GO:0032787,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0046459,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840	2.8.3.1,2.8.3.8	ko:K01026,ko:K19709	ko00620,ko00627,ko00640,ko00643,ko00650,ko01100,ko01120,map00620,map00627,map00640,map00643,map00650,map01100,map01120		R00928,R01179,R01359,R01449,R05508,R07832	RC00012,RC00014,RC00137	ko00000,ko00001,ko01000				Bacteria	1MUJW@1224,1RP80@1236,3XM2K@561,COG4670@1,COG4670@2	NA|NA|NA	I	CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons
C1_01484	155864.EDL933_2650	7.3e-130	469.9	Escherichia	aroD	GO:0000166,GO:0003674,GO:0003824,GO:0003855,GO:0004764,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006725,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009712,GO:0009713,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018958,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0042537,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046189,GO:0046278,GO:0046279,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1901615,GO:1901617	1.1.1.25,4.2.1.10	ko:K03785,ko:K13832	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413,R03084	RC00206,RC00848	ko00000,ko00001,ko00002,ko01000			iEC042_1314.EC042_1860	Bacteria	1NG0G@1224,1RYZ4@1236,3XNW3@561,COG0710@1,COG0710@2	NA|NA|NA	E	Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate
C1_01485	199310.c2087	1.8e-161	575.1	Escherichia	aroE	GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0030266,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0051287,GO:0052734,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615	1.1.1.25,1.1.1.282,1.3.5.4	ko:K00014,ko:K00244,ko:K05887	ko00020,ko00190,ko00400,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko02020,map00020,map00190,map00400,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map01230,map02020	M00009,M00011,M00022,M00150,M00173	R01872,R02164,R02413,R06846,R06847	RC00045,RC00154,RC00206	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_3165,iECOK1_1307.ECOK1_3701,iECS88_1305.ECS88_3669,iECUMN_1333.ECUMN_3755,iHN637.CLJU_RS14185,iSFxv_1172.SFxv_1929,iS_1188.S1854,iUMN146_1321.UM146_16315,iUTI89_1310.UTI89_C3726	Bacteria	1MVH4@1224,1RS73@1236,3XNUP@561,COG0169@1,COG0169@2	NA|NA|NA	E	The actual biological function of YdiB remains unclear, nor is it known whether 3-dehydroshikimate or quinate represents the natural substrate. Catalyzes the reversible NAD-dependent reduction of both 3-dehydroshikimate (DHSA) and 3-dehydroquinate to yield shikimate (SA) and quinate, respectively. It can use both NAD or NADP for catalysis, however it has higher catalytic efficiency with NAD
C1_01486	155864.EDL933_2648	3.5e-225	787.3	Escherichia	ydiN			ko:K03762					ko00000,ko02000	2.A.1.6.4			Bacteria	1R5EA@1224,1RQ30@1236,3XM5V@561,COG0477@1,COG0477@2	NA|NA|NA	EGP	Major Facilitator Superfamily
C1_01487	481805.EcolC_1941	1.7e-221	775.0	Escherichia	ydiM	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02429,ko:K06141					ko00000,ko02000	2.A.1,2.A.1.7			Bacteria	1PMZX@1224,1RZE0@1236,3XNRY@561,COG0738@1,COG0738@2	NA|NA|NA	P	transporter activity
C1_01488	316407.85675077	7.3e-64	249.6	Escherichia	ydiL												Bacteria	1MYSY@1224,1S6TE@1236,2C13B@1,32R81@2,3XQZG@561	NA|NA|NA	S	DNA binding
C1_01489	198214.SF1718	1.7e-196	691.8	Gammaproteobacteria	ydiK	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944		ko:K03548,ko:K11744					ko00000,ko02000	2.A.86.1			Bacteria	1MVX7@1224,1RNN1@1236,COG0628@1,COG0628@2	NA|NA|NA	S	ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated
C1_01490	199310.c2082	0.0	2041.5	Escherichia	ydiJ	GO:0000166,GO:0003674,GO:0005488,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050662,GO:0051536,GO:0051539,GO:0051540,GO:0097159,GO:1901265,GO:1901363											Bacteria	1MU6Y@1224,1RQX2@1236,3XM9Z@561,COG0247@1,COG0247@2,COG0277@1,COG0277@2	NA|NA|NA	C	flavin adenine dinucleotide binding
C1_01491	316407.1742761	9.9e-73	279.3	Escherichia	menI	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006725,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009237,GO:0009238,GO:0009239,GO:0009712,GO:0009713,GO:0009987,GO:0016289,GO:0016787,GO:0016788,GO:0016790,GO:0018130,GO:0018958,GO:0019184,GO:0019290,GO:0019438,GO:0019540,GO:0019748,GO:0034641,GO:0042180,GO:0042181,GO:0042802,GO:0043043,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0046189,GO:0046483,GO:0051186,GO:0051188,GO:0061522,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663	3.1.2.28	ko:K19222	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R07262	RC00004,RC00174	ko00000,ko00001,ko00002,ko01000				Bacteria	1RGVP@1224,1S5WY@1236,3XPMU@561,COG2050@1,COG2050@2	NA|NA|NA	Q	Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl- CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA)
C1_01492	198214.SF1715	1.2e-25	121.7	Gammaproteobacteria	ydiH												Bacteria	1N8X4@1224,1SCDQ@1236,2E58W@1,3301A@2	NA|NA|NA	S	Domain of unknown function
C1_01493	316407.1742762	1.6e-66	258.5	Escherichia	sufA	GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016043,GO:0016226,GO:0016530,GO:0019538,GO:0022607,GO:0031163,GO:0034986,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0050896,GO:0051186,GO:0051536,GO:0051537,GO:0051540,GO:0051604,GO:0071704,GO:0071840,GO:0097428,GO:0140104,GO:1901564		ko:K05997,ko:K13628					ko00000,ko03016			iAPECO1_1312.APECO1_3997,iB21_1397.B21_02384,iBWG_1329.BWG_2292,iE2348C_1286.E2348C_2811,iEC042_1314.EC042_2732,iEC55989_1330.EC55989_2813,iECABU_c1320.ECABU_c28340,iECBD_1354.ECBD_1156,iECB_1328.ECB_02420,iECDH10B_1368.ECDH10B_2695,iECD_1391.ECD_02420,iECED1_1282.ECED1_2959,iECIAI1_1343.ECIAI1_2580,iECIAI39_1322.ECIAI39_2729,iECNA114_1301.ECNA114_2607,iECO103_1326.ECO103_3045,iECO111_1330.ECO111_3252,iECO26_1355.ECO26_3575,iECOK1_1307.ECOK1_2877,iECP_1309.ECP_2533,iECS88_1305.ECS88_2704,iECSE_1348.ECSE_2814,iECSF_1327.ECSF_2372,iECSP_1301.ECSP_3472,iECUMN_1333.ECUMN_2848,iECW_1372.ECW_m2754,iECs_1301.ECs3394,iEKO11_1354.EKO11_1205,iETEC_1333.ETEC_2685,iEcDH1_1363.EcDH1_1140,iEcSMS35_1347.EcSMS35_2681,iEcolC_1368.EcolC_1149,iG2583_1286.G2583_3058,iJO1366.b2528,iLF82_1304.LF82_1120,iNRG857_1313.NRG857_12580,iSBO_1134.SBO_2552,iSDY_1059.SDY_2724,iSF_1195.SF2575,iSSON_1240.SSON_2610,iS_1188.S2747,iUMN146_1321.UM146_04060,iUMNK88_1353.UMNK88_3181,iWFL_1372.ECW_m2754,iY75_1357.Y75_RS13195,iZ_1308.Z3795,ic_1306.c3053	Bacteria	1RH6T@1224,1S5XD@1236,3XPKS@561,COG0316@1,COG0316@2	NA|NA|NA	S	Belongs to the HesB IscA family
C1_01494	316407.85675075	5e-292	1009.6	Escherichia	sufB	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006790,GO:0008150,GO:0008152,GO:0009536,GO:0009842,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0071840		ko:K07033,ko:K09014					ko00000			iAPECO1_1312.APECO1_760,iECH74115_1262.ECH74115_2397,iECSF_1327.ECSF_1543,iECSP_1301.ECSP_2250,iUTI89_1310.UTI89_C1875,ic_1306.c2078	Bacteria	1MVKY@1224,1RQ65@1236,3XND6@561,COG0719@1,COG0719@2	NA|NA|NA	O	The SufBCD complex acts synergistically with SufE to stimulate the cysteine desulfurase activity of SufS. The SufBCD complex contributes to the assembly or repair of oxygen-labile iron-sulfur clusters under oxidative stress. May facilitate iron uptake from extracellular iron chelators under iron limitation
C1_01495	155864.EDL933_2639	2.2e-134	485.0	Escherichia	sufC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0071840		ko:K09013					ko00000,ko02000			iECH74115_1262.ECH74115_2396,iECIAI1_1343.ECIAI1_1734,iECIAI39_1322.ECIAI39_1376,iECSP_1301.ECSP_2249,iECs_1301.ECs2389,iEcSMS35_1347.EcSMS35_1514,iG2583_1286.G2583_2077,iSFV_1184.SFV_1705,iSFxv_1172.SFxv_1919,iSSON_1240.SSON_1474,iS_1188.S1844,iZ_1308.Z2710	Bacteria	1MUGK@1224,1RPFE@1236,3XNS8@561,COG0396@1,COG0396@2	NA|NA|NA	P	Has low ATPase activity. The SufBCD complex acts synergistically with SufE to stimulate the cysteine desulfurase activity of SufS. The SufBCD complex contributes to the assembly or repair of oxygen-labile iron-sulfur clusters under oxidative stress. May facilitate iron uptake from extracellular iron chelators under iron limitation
C1_01496	469008.B21_01640	1.1e-239	835.5	Escherichia	sufD	GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0040007,GO:0043207,GO:0044085,GO:0044237,GO:0044403,GO:0044419,GO:0050896,GO:0051186,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071840,GO:0075136		ko:K07033,ko:K09015					ko00000			iB21_1397.B21_01640,iECBD_1354.ECBD_1964,iECB_1328.ECB_01650,iECD_1391.ECD_01650,iUMNK88_1353.UMNK88_2144	Bacteria	1MVK0@1224,1RP2A@1236,3XM2Q@561,COG0719@1,COG0719@2	NA|NA|NA	O	The SufBCD complex acts synergistically with SufE to stimulate the cysteine desulfurase activity of SufS. The SufBCD complex contributes to the assembly or repair of oxygen-labile iron-sulfur clusters under oxidative stress. May facilitate iron uptake from extracellular iron chelators under iron limitation. Required for the stability of the FhuF protein
C1_01497	155864.EDL933_2637	1.3e-234	818.5	Escherichia	sufS	GO:0001887,GO:0003674,GO:0003824,GO:0005488,GO:0006464,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009000,GO:0009987,GO:0016043,GO:0016226,GO:0016740,GO:0016782,GO:0016783,GO:0016829,GO:0016846,GO:0019538,GO:0019842,GO:0022607,GO:0030170,GO:0031071,GO:0031162,GO:0031163,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0048037,GO:0050662,GO:0051186,GO:0070279,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564	2.8.1.7,4.4.1.16	ko:K01766,ko:K11717	ko00450,ko01100,map00450,map01100		R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_3722,iAPECO1_1312.APECO1_757,iEC55989_1330.EC55989_1847,iECED1_1282.ECED1_1879,iECO111_1330.ECO111_2149,iECO26_1355.ECO26_2408,iECOK1_1307.ECOK1_1800,iECS88_1305.ECS88_1730,iECS88_1305.ECS88_3079,iECW_1372.ECW_m1847,iEKO11_1354.EKO11_2095,iUMN146_1321.UM146_08755,iUTI89_1310.UTI89_C1872,iWFL_1372.ECW_m1847	Bacteria	1MUPD@1224,1RNIY@1236,3XMA9@561,COG0520@1,COG0520@2	NA|NA|NA	H	Cysteine desulfurases mobilize the sulfur from L- cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L-selenocysteine. Selenocysteine lyase activity is however unsure in vivo
C1_01498	316407.85675074	1.6e-70	271.9	Escherichia	sufE	GO:0003674,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006464,GO:0006725,GO:0006790,GO:0006807,GO:0006950,GO:0006979,GO:0008033,GO:0008047,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0019538,GO:0022607,GO:0030234,GO:0031162,GO:0031163,GO:0034470,GO:0034641,GO:0034660,GO:0036211,GO:0043085,GO:0043170,GO:0043412,GO:0044085,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046483,GO:0050790,GO:0050896,GO:0061504,GO:0065007,GO:0065009,GO:0071704,GO:0071840,GO:0090304,GO:0097163,GO:0098772,GO:0140104,GO:1901360,GO:1901564	2.8.1.7,4.4.1.16	ko:K02426,ko:K11717	ko00450,ko01100,map00450,map01100		R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000			iSBO_1134.SBO_1451,iSFV_1184.SFV_1702,iSF_1195.SF1708,iSFxv_1172.SFxv_1916,iS_1188.S1841,iSbBS512_1146.SbBS512_E1880	Bacteria	1RI8F@1224,1S65C@1236,3XPKR@561,COG2166@1,COG2166@2	NA|NA|NA	S	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process
C1_01499	198214.SF1707	1.5e-186	658.7	Gammaproteobacteria	ycfS	GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008234,GO:0008236,GO:0008238,GO:0009273,GO:0009987,GO:0016740,GO:0016746,GO:0016755,GO:0016787,GO:0016807,GO:0017171,GO:0019538,GO:0042546,GO:0043164,GO:0043170,GO:0044036,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0070004,GO:0070008,GO:0070011,GO:0071554,GO:0071704,GO:0071840,GO:0071972,GO:0140096,GO:1901564		ko:K16291,ko:K19234,ko:K19235,ko:K19236	ko01503,map01503				ko00000,ko00001,ko01002,ko01011				Bacteria	1MVYT@1224,1RMNC@1236,COG1376@1,COG1376@2	NA|NA|NA	M	ErfK YbiS YcfS YnhG family protein
C1_01500	1440052.EAKF1_ch4375c	6.6e-21	106.3	Escherichia	lpp	GO:0003674,GO:0005488,GO:0005515,GO:0005539,GO:0005575,GO:0005623,GO:0006629,GO:0008150,GO:0008152,GO:0008289,GO:0009279,GO:0009987,GO:0016020,GO:0016021,GO:0019867,GO:0030258,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031975,GO:0042802,GO:0042834,GO:0044237,GO:0044238,GO:0044255,GO:0044425,GO:0044462,GO:0044464,GO:0045203,GO:0071704,GO:0071944,GO:0097367		ko:K06078					ko00000,ko01011				Bacteria	1MZCW@1224,1S8YB@1236,3XQ0U@561,COG4238@1,COG4238@2	NA|NA|NA	M	Lipoprotein leucine-zipper
C1_01501	155864.EDL933_2633	2.2e-260	904.4	Escherichia	pyk	GO:0001871,GO:0003674,GO:0003824,GO:0004743,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006116,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009266,GO:0009408,GO:0009628,GO:0009986,GO:0009987,GO:0016043,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0019693,GO:0019752,GO:0022607,GO:0030246,GO:0030247,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:2001065	2.7.1.40,2.7.7.4	ko:K00873,ko:K00958	ko00010,ko00230,ko00261,ko00450,ko00620,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00261,map00450,map00620,map00920,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050,M00176,M00596	R00200,R00430,R00529,R01138,R01858,R02320,R04929	RC00002,RC00015,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147			iECO103_1326.ECO103_1819,iEcE24377_1341.EcE24377A_2084,iPC815.YPO2393	Bacteria	1MU21@1224,1RMW3@1236,3XMTB@561,COG0469@1,COG0469@2	NA|NA|NA	F	Pyruvate kinase
C1_01502	198214.SF1703	5.2e-30	136.3	Gammaproteobacteria	ydhZ	GO:0003674,GO:0003824,GO:0004333,GO:0016829,GO:0016835,GO:0016836											Bacteria	1N1HX@1224,1SDWM@1236,2D4UA@1,32THM@2	NA|NA|NA	S	fumarate hydratase activity
C1_01503	155864.EDL933_2630	4.3e-112	410.6	Escherichia	ydhY												Bacteria	1MUIE@1224,1RZEF@1236,3XQFQ@561,COG0437@1,COG0437@2	NA|NA|NA	C	4 iron, 4 sulfur cluster binding
C1_01504	481805.EcolC_1958	0.0	1457.2	Escherichia	ydhV	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016614,GO:0030151,GO:0033719,GO:0043167,GO:0043169,GO:0043546,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071944,GO:0097159,GO:1901363	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000				Bacteria	1MWBB@1224,1RSCT@1236,3XQTC@561,COG2414@1,COG2414@2	NA|NA|NA	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor
C1_01505	481805.EcolC_1959	3e-116	424.5	Escherichia	ydhW												Bacteria	1RBE4@1224,1S3H4@1236,28VFF@1,2ZHI0@2,3XQRK@561	NA|NA|NA		
C1_01506	481805.EcolC_1960	9e-132	476.1	Escherichia	ydhX	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464		ko:K04014,ko:K08353,ko:K08358	ko00920,ko01120,ko02020,map00920,map01120,map02020		R10149,R10150	RC02823,RC03109	ko00000,ko00001,ko02000	5.A.3.10,5.A.3.5		iUMNK88_1353.UMNK88_4933	Bacteria	1R5IV@1224,1RR1Z@1236,3XQ9N@561,COG0437@1,COG0437@2	NA|NA|NA	C	4 iron, 4 sulfur cluster binding
C1_01507	198214.SF1698	5.6e-149	533.5	Gammaproteobacteria	ydhU	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03620,ko:K08354	ko00920,ko01120,ko02020,map00920,map01120,map02020		R10149	RC02823	ko00000,ko00001,ko02000	5.A.3.5			Bacteria	1R4HB@1224,1RSIU@1236,COG4117@1,COG4117@2	NA|NA|NA	C	Thiosulfate reductase cytochrome b subunit
C1_01508	481805.EcolC_1962	2.3e-62	245.7	Gammaproteobacteria													Bacteria	1R0GE@1224,1T4GZ@1236,2DPK0@1,332FP@2	NA|NA|NA		
C1_01509	481805.EcolC_1963	1.6e-307	1061.2	Escherichia	ydhS												Bacteria	1N8CF@1224,1RS86@1236,3XP0H@561,COG4529@1,COG4529@2	NA|NA|NA	S	FAD-NAD(P)-binding
C1_01510	198214.SF1695	6e-51	206.5	Gammaproteobacteria	ydhR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Bacteria	1MZC2@1224,1S98Z@1236,2C948@1,32SAI@2	NA|NA|NA	S	monooxygenase
C1_01513	481805.EcolC_1965	7.5e-188	663.3	Escherichia	ydhQ	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716	2.7.11.1	ko:K12132					ko00000,ko01000,ko01001				Bacteria	1NQVP@1224,1SMRB@1236,3XNU0@561,COG3468@1,COG3468@2	NA|NA|NA	MU	cellular response to DNA damage stimulus
C1_01514	316407.1742737	3.2e-248	864.0	Escherichia	mdtK	GO:0000302,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0006857,GO:0006862,GO:0006950,GO:0006979,GO:0008150,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015215,GO:0015230,GO:0015238,GO:0015605,GO:0015711,GO:0015748,GO:0015833,GO:0015893,GO:0015931,GO:0015932,GO:0016020,GO:0022857,GO:0033554,GO:0034220,GO:0034599,GO:0034614,GO:0035350,GO:0035442,GO:0035672,GO:0035673,GO:0042221,GO:0042493,GO:0042886,GO:0042887,GO:0042891,GO:0042895,GO:0042938,GO:0044464,GO:0044610,GO:0046677,GO:0050896,GO:0051179,GO:0051181,GO:0051182,GO:0051184,GO:0051185,GO:0051234,GO:0051716,GO:0055085,GO:0070887,GO:0071702,GO:0071705,GO:0071916,GO:0071944,GO:0098656,GO:1901264,GO:1901505,GO:1901679,GO:1901700,GO:1901701,GO:1904680		ko:K03327					ko00000,ko02000	2.A.66.1			Bacteria	1MUAM@1224,1RP5M@1236,3XMVX@561,COG0534@1,COG0534@2	NA|NA|NA	P	Multidrug efflux pump that functions probably as a Na( ) drug antiporter
C1_01515	198214.SF1690	7.1e-118	429.9	Gammaproteobacteria	ribE	GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000			iECABU_c1320.ECABU_c19160,iECP_1309.ECP_1609,ic_1306.c2056	Bacteria	1MUMB@1224,1RMSY@1236,COG0307@1,COG0307@2	NA|NA|NA	H	Riboflavin synthase
C1_01516	199310.c2055	1.8e-228	798.1	Escherichia	cfa	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0008825,GO:0009987,GO:0016740,GO:0016741,GO:0030258,GO:0032259,GO:0044237,GO:0044238,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0071704	2.1.1.317,2.1.1.79	ko:K00574,ko:K20238					ko00000,ko01000			iEC55989_1330.EC55989_1829,iECIAI1_1343.ECIAI1_1713,iECO103_1326.ECO103_1803,iECSE_1348.ECSE_1785,iEcE24377_1341.EcE24377A_1875	Bacteria	1MX3U@1224,1RNID@1236,3XMDR@561,COG2230@1,COG2230@2	NA|NA|NA	M	Transfers a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge
C1_01517	469008.B21_01620	1.7e-221	775.0	Escherichia	ydhC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1N196@1224,1RPMD@1236,3XMDG@561,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
C1_01518	155864.EDL933_2617	5.4e-183	646.7	Escherichia	ydhB			ko:K10972					ko00000,ko03000				Bacteria	1P293@1224,1RPK0@1236,3XMPY@561,COG0583@1,COG0583@2	NA|NA|NA	K	DNA-binding transcription factor activity
C1_01519	155864.EDL933_2616	1.3e-193	682.2	Escherichia	purR	GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0002054,GO:0002057,GO:0002060,GO:0003674,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006140,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010563,GO:0010605,GO:0010629,GO:0019219,GO:0019220,GO:0019222,GO:0030808,GO:0030809,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036094,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0045936,GO:0045980,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051174,GO:0051252,GO:0051253,GO:0060255,GO:0062012,GO:0062014,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1900371,GO:1900372,GO:1900542,GO:1900543,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K02529,ko:K03604					ko00000,ko03000				Bacteria	1MVUR@1224,1RN2K@1236,3XNMI@561,COG1609@1,COG1609@2	NA|NA|NA	K	Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression
C1_01521	316407.1742730	5.9e-203	713.4	Escherichia	ydhP	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K08156,ko:K19577					ko00000,ko02000	2.A.1.2.14,2.A.1.2.65			Bacteria	1MU9G@1224,1RM9G@1236,3XM7H@561,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
C1_01522	155864.EDL933_2613	3.2e-109	401.0	Escherichia	sodB	GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748	1.15.1.1,3.1.11.6	ko:K03601,ko:K04564	ko03430,ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map03430,map04013,map04068,map04146,map04211,map04212,map04213,map05016				ko00000,ko00001,ko01000,ko03400			iAF1260.b1656,iAPECO1_1312.APECO1_736,iB21_1397.B21_01616,iBWG_1329.BWG_1471,iE2348C_1286.E2348C_1742,iE2348C_1286.E2348C_4213,iEC042_1314.EC042_1825,iEC55989_1330.EC55989_1824,iECABU_c1320.ECABU_c19090,iECBD_1354.ECBD_1987,iECB_1328.ECB_01626,iECDH10B_1368.ECDH10B_1790,iECDH1ME8569_1439.ECDH1ME8569_1601,iECD_1391.ECD_01626,iECED1_1282.ECED1_1855,iECH74115_1262.ECH74115_2368,iECIAI1_1343.ECIAI1_1708,iECO103_1326.ECO103_1797,iECO111_1330.ECO111_2126,iECO26_1355.ECO26_2385,iECOK1_1307.ECOK1_1775,iECP_1309.ECP_1601,iECS88_1305.ECS88_1705,iECSE_1348.ECSE_1780,iECSF_1327.ECSF_3769,iECSP_1301.ECSP_2222,iECUMN_1333.ECUMN_1946,iECW_1372.ECW_m1823,iECs_1301.ECs2365,iEKO11_1354.EKO11_2118,iETEC_1333.ETEC_1691,iEcDH1_1363.EcDH1_1984,iEcE24377_1341.EcE24377A_1869,iEcHS_1320.EcHS_A1735,iEcSMS35_1347.EcSMS35_1542,iEcolC_1368.EcolC_1973,iG2583_1286.G2583_2051,iJO1366.b1656,iJR904.b1656,iLF82_1304.LF82_2148,iNRG857_1313.NRG857_08300,iSBO_1134.SBO_1475,iSDY_1059.SDY_1882,iSFV_1184.SFV_1678,iSF_1195.SF1684,iSFxv_1172.SFxv_1892,iSSON_1240.SSON_1500,iS_1188.S1816,iSbBS512_1146.SbBS512_E1853,iUMN146_1321.UM146_08870,iUMNK88_1353.UMNK88_2117,iUTI89_1310.UTI89_C1847,iWFL_1372.ECW_m1823,iY75_1357.Y75_RS08680,iZ_1308.Z2678,ic_1306.c2050	Bacteria	1MVW2@1224,1RP7X@1236,3XN20@561,COG0605@1,COG0605@2	NA|NA|NA	C	radicals which are normally produced within the cells and which are toxic to biological systems
C1_01523	316407.85675064	1.7e-132	478.8	Escherichia	ydhO	GO:0000270,GO:0003674,GO:0003824,GO:0004175,GO:0006022,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009254,GO:0016787,GO:0019538,GO:0030203,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901135,GO:1901564	3.2.1.14,3.4.17.13	ko:K01183,ko:K13694,ko:K13695,ko:K19303,ko:K21471	ko00520,ko01100,map00520,map01100		R01206,R02334	RC00467	ko00000,ko00001,ko01000,ko01002,ko01011		GH18		Bacteria	1N0EE@1224,1RP3P@1236,3XN56@561,COG0791@1,COG0791@2	NA|NA|NA	M	A murein DD-endopeptidase with specificity for D-Ala- meso-diaminopimelic acid (mDAP) cross-links. Its role is probably to cleave D-Ala-mDAP cross-links to allow insertion of new glycans and thus cell wall expansion. Functionally redundant with MepM and MepH. Partially suppresses an mepS disruption mutant
C1_01524	1440052.EAKF1_ch4396	1.8e-59	235.0	Escherichia	grxD	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051536,GO:0051537,GO:0051540		ko:K07390					ko00000,ko03029,ko03110			iPC815.YPO2383,iYL1228.KPN_01992	Bacteria	1MZ4V@1224,1S640@1236,3XPRG@561,COG0278@1,COG0278@2	NA|NA|NA	O	Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters
C1_01525	469008.B21_01613	0.0	2979.1	Escherichia	lhr	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360		ko:K03724					ko00000,ko01000,ko03400				Bacteria	1MUSW@1224,1RSNV@1236,3XQ5E@561,COG1201@1,COG1201@2	NA|NA|NA	L	RNA secondary structure unwinding
C1_01526	155864.EDL933_2609	1.8e-121	441.8	Escherichia	rnt	GO:0000287,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0031123,GO:0034470,GO:0034641,GO:0034660,GO:0042780,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360		ko:K03683					ko00000,ko01000,ko03016				Bacteria	1MUPK@1224,1RMMH@1236,3XPFQ@561,COG0847@1,COG0847@2	NA|NA|NA	J	Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis
C1_01527	155864.EDL933_2608	4.1e-71	273.9	Escherichia	gloA	GO:0003674,GO:0003824,GO:0004462,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006089,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016151,GO:0016829,GO:0016846,GO:0019243,GO:0019752,GO:0032787,GO:0034641,GO:0042180,GO:0042182,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0046872,GO:0046914,GO:0051186,GO:0051596,GO:0061727,GO:0071704,GO:1901564,GO:1901575,GO:1901615	4.4.1.5	ko:K01759	ko00620,map00620		R02530	RC00004,RC00740	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_733,iECABU_c1320.ECABU_c19040,iECED1_1282.ECED1_1851,iECNA114_1301.ECNA114_1699,iECOK1_1307.ECOK1_1770,iECP_1309.ECP_1597,iECS88_1305.ECS88_1700,iECSF_1327.ECSF_1514,iLF82_1304.LF82_0861,iNRG857_1313.NRG857_08275,iUMN146_1321.UM146_08895,iUTI89_1310.UTI89_C1842,ic_1306.c2044	Bacteria	1RCYX@1224,1S1Z9@1236,3XPJX@561,COG0346@1,COG0346@2	NA|NA|NA	E	Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione
C1_01528	316407.85675061	1.1e-208	732.3	Escherichia	nemA	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006805,GO:0006807,GO:0008150,GO:0008152,GO:0008748,GO:0009056,GO:0009410,GO:0009987,GO:0010181,GO:0016491,GO:0016627,GO:0016628,GO:0016661,GO:0017144,GO:0018937,GO:0018973,GO:0018974,GO:0019326,GO:0019439,GO:0032553,GO:0034567,GO:0036094,GO:0042221,GO:0042537,GO:0043167,GO:0043168,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046256,GO:0046260,GO:0046263,GO:0046857,GO:0048037,GO:0050662,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071466,GO:0071704,GO:0072490,GO:0072491,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575		ko:K10680	ko00633,ko01120,map00633,map01120		R08014,R08017,R08042	RC00250	ko00000,ko00001,ko01000				Bacteria	1MVIX@1224,1RMFI@1236,3XMN8@561,COG1902@1,COG1902@2	NA|NA|NA	C	N-ethylmaleimide reductase activity
C1_01529	199310.c2042	1.3e-108	399.1	Escherichia	nemR	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K16137					ko00000,ko03000				Bacteria	1RA4T@1224,1RNQH@1236,3XP6H@561,COG1309@1,COG1309@2	NA|NA|NA	K	Represses the transcription of the nemRA operon by binding to the nemR box
C1_01530	316407.85675059	1.6e-38	164.9	Escherichia	ydhL			ko:K06938					ko00000				Bacteria	1NGD5@1224,1SCBM@1236,3XPYQ@561,COG3313@1,COG3313@2	NA|NA|NA	S	Protein of unknown function (DUF1289)
C1_01531	316407.85675058	3.8e-170	604.0	Escherichia	ydhF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Bacteria	1MY3G@1224,1RRIC@1236,3XNH4@561,COG4989@1,COG4989@2	NA|NA|NA	S	oxidoreductase activity
C1_01532	155864.EDL933_2602	1.2e-91	342.4	Escherichia	sodC	GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0005488,GO:0005507,GO:0005575,GO:0005576,GO:0005615,GO:0005623,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008270,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0030288,GO:0030313,GO:0031975,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0042597,GO:0043167,GO:0043169,GO:0044237,GO:0044421,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748	1.15.1.1	ko:K04565	ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020				ko00000,ko00001,ko01000			iEcolC_1368.EcolC_1983	Bacteria	1RGV4@1224,1S6KW@1236,3XPCR@561,COG2032@1,COG2032@2	NA|NA|NA	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C1_01533	469008.B21_01605	0.0	1300.8	Escherichia	ydhK	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1MX9H@1224,1RMJ4@1236,3XNU5@561,COG1289@1,COG1289@2	NA|NA|NA	S	transmembrane transporter activity
C1_01534	469008.B21_01604	8.7e-139	499.6	Escherichia	ydhJ	GO:0003674,GO:0005215,GO:0006810,GO:0006855,GO:0008150,GO:0015238,GO:0015546,GO:0015893,GO:0015906,GO:0022857,GO:0042221,GO:0042493,GO:0042886,GO:0042887,GO:0042891,GO:0042895,GO:0042908,GO:0042910,GO:0045117,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0072348,GO:1901474,GO:1901682,GO:1902599		ko:K03543,ko:K15548,ko:K15549		M00701			ko00000,ko00002,ko02000	8.A.1.1,8.A.1.1.3,8.A.1.7.1			Bacteria	1MWG0@1224,1RRE3@1236,3XNR4@561,COG1566@1,COG1566@2	NA|NA|NA	V	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1_01535	155864.EDL933_2599	3.8e-37	160.2	Escherichia	ydhI												Bacteria	1NCAP@1224,1SD9Z@1236,2E3ZD@1,32YWB@2,3XQ01@561	NA|NA|NA	S	Protein of unknown function (DUF1656)
C1_01536	155864.EDL933_2598	1.4e-72	278.9	Escherichia	slyA	GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031333,GO:0031334,GO:0043254,GO:0044087,GO:0044089,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051130,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2000144,GO:2001141		ko:K06075					ko00000,ko03000				Bacteria	1N78T@1224,1S26B@1236,3XPIP@561,COG1846@1,COG1846@2	NA|NA|NA	K	Transcription regulator that can specifically activate or repress expression of target genes
C1_01537	155864.EDL933_2597	2.5e-56	224.9	Escherichia	slyB	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944		ko:K06077					ko00000				Bacteria	1RA1D@1224,1S202@1236,3XPJ7@561,COG3133@1,COG3133@2	NA|NA|NA	M	Outer membrane lipoprotein slyB
C1_01538	469008.B21_01600	2.7e-213	747.7	Escherichia	anmK	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0044237	2.7.1.170,4.2.1.126	ko:K07106,ko:K09001	ko00520,ko01100,map00520,map01100		R08555	RC00397,RC00746	ko00000,ko00001,ko01000			iECABU_c1320.ECABU_c18930,iECED1_1282.ECED1_1841,ic_1306.c2032	Bacteria	1MV4E@1224,1RNTZ@1236,3XNN7@561,COG2377@1,COG2377@2	NA|NA|NA	F	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C1_01539	199310.c2031	5.2e-53	213.4	Escherichia	mliC	GO:0003674,GO:0004857,GO:0005575,GO:0005623,GO:0008150,GO:0009279,GO:0016020,GO:0019867,GO:0030234,GO:0030312,GO:0030313,GO:0031975,GO:0043086,GO:0044092,GO:0044462,GO:0044464,GO:0050790,GO:0060241,GO:0065007,GO:0065009,GO:0071944,GO:0098772											Bacteria	1N4BY@1224,1S3XI@1236,3XPRD@561,COG3895@1,COG3895@2	NA|NA|NA	S	Membrane-bound lysozyme-inhibitor of c-type lysozyme
C1_01540	198214.SF1663	1.2e-123	449.1	Gammaproteobacteria	pdxH	GO:0000166,GO:0003674,GO:0003824,GO:0004733,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009108,GO:0009110,GO:0009443,GO:0009987,GO:0010181,GO:0016491,GO:0016638,GO:0016641,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019842,GO:0032553,GO:0032991,GO:0034641,GO:0036094,GO:0042301,GO:0042364,GO:0042802,GO:0042803,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043094,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902444	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000				Bacteria	1NZUU@1224,1RMQ2@1236,COG0259@1,COG0259@2	NA|NA|NA	H	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)
C1_01541	155864.EDL933_2593	1.6e-246	858.2	Escherichia	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006437,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029			iAF1260.b1637,iBWG_1329.BWG_1452,iECDH10B_1368.ECDH10B_1771,iECDH1ME8569_1439.ECDH1ME8569_1581,iECH74115_1262.ECH74115_2349,iECIAI39_1322.ECIAI39_1418,iECNA114_1301.ECNA114_1685,iECO103_1326.ECO103_1778,iECO111_1330.ECO111_2107,iECO26_1355.ECO26_2366,iECSE_1348.ECSE_1760,iECSF_1327.ECSF_1500,iECSP_1301.ECSP_2202,iECUMN_1333.ECUMN_1928,iECW_1372.ECW_m1805,iECs_1301.ECs2346,iEKO11_1354.EKO11_2137,iETEC_1333.ETEC_1672,iEcDH1_1363.EcDH1_2003,iEcE24377_1341.EcE24377A_1847,iEcHS_1320.EcHS_A1713,iEcSMS35_1347.EcSMS35_1562,iEcolC_1368.EcolC_1992,iJO1366.b1637,iSFV_1184.SFV_1654,iSF_1195.SF1662,iSSON_1240.SSON_1519,iSbBS512_1146.SbBS512_E1829,iUMNK88_1353.UMNK88_2097,iWFL_1372.ECW_m1805,iY75_1357.Y75_RS08585	Bacteria	1MVUQ@1224,1RPKC@1236,3XM5P@561,COG0162@1,COG0162@2	NA|NA|NA	J	to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C1_01542	316407.1742702	9.1e-161	572.8	Escherichia	pdxY	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008478,GO:0009058,GO:0009108,GO:0009110,GO:0009443,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0042364,GO:0042802,GO:0042816,GO:0042817,GO:0042819,GO:0042822,GO:0042823,GO:0043094,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	2.7.1.35	ko:K00868	ko00750,ko01100,map00750,map01100		R00174,R01909,R02493	RC00002,RC00017	ko00000,ko00001,ko01000			iE2348C_1286.E2348C_1723	Bacteria	1MVC9@1224,1RMIE@1236,3XMBR@561,COG2240@1,COG2240@2	NA|NA|NA	H	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C1_01543	155864.EDL933_2591	1.6e-111	408.7	Escherichia	gst	GO:0000302,GO:0003674,GO:0003824,GO:0004364,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0009636,GO:0010035,GO:0016740,GO:0016765,GO:0042221,GO:0042493,GO:0042542,GO:0044424,GO:0044464,GO:0046677,GO:0050896,GO:1901700	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418		R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2			Bacteria	1MY47@1224,1RRI3@1236,3XMJY@561,COG0625@1,COG0625@2	NA|NA|NA	O	Catalyzes the conjugation of reduced glutathione (GSH) to a wide number of exogenous and endogenous hydrophobic electrophiles. Shows activity toward 1-chloro-2,4-dinitrobenzene (CDNB) and ethacrynic acid. Also possesses thiol disulfide oxidoreductase activity, using GSH to reduce bis-(2-hydroxyethyl) disulfide (HEDS). Has a low level of glutathione-dependent peroxidase activity toward cumene hydroperoxide. Is important for defense against oxidative stress, probably via its peroxidase activity
C1_01544	316407.1742700	1.8e-276	958.0	Escherichia	dtpA	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006855,GO:0006857,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015238,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015333,GO:0015672,GO:0015833,GO:0015893,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0035442,GO:0035443,GO:0035672,GO:0035673,GO:0042221,GO:0042493,GO:0042886,GO:0042887,GO:0042891,GO:0042895,GO:0042937,GO:0042938,GO:0042939,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071916,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600,GO:1904680		ko:K03305					ko00000	2.A.17		iB21_1397.B21_01594,iBWG_1329.BWG_1449,iEC042_1314.EC042_1803,iECBD_1354.ECBD_2009,iECB_1328.ECB_01604,iECDH10B_1368.ECDH10B_1768,iECDH1ME8569_1439.ECDH1ME8569_1578,iECD_1391.ECD_01604,iECH74115_1262.ECH74115_4843,iECSP_1301.ECSP_4476,iECUMN_1333.ECUMN_1925,iECs_1301.ECs4368,iETEC_1333.ETEC_1669,iEcDH1_1363.EcDH1_2006,iEcSMS35_1347.EcSMS35_1565,iEcolC_1368.EcolC_1995,iJO1366.b1634,iUMNK88_1353.UMNK88_2094,iY75_1357.Y75_RS08570,iZ_1308.Z4896	Bacteria	1MW6W@1224,1RM8P@1236,3XMRM@561,COG3104@1,COG3104@2	NA|NA|NA	U	Proton-dependent permease that transports di- and tripeptides
C1_01546	199310.c2025	1.7e-116	425.2	Escherichia	nth	GO:0000702,GO:0000703,GO:0003674,GO:0003824,GO:0003906,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0034644,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071214,GO:0071478,GO:0071482,GO:0071704,GO:0090304,GO:0104004,GO:0140097,GO:1901360	4.2.99.18	ko:K10773	ko03410,map03410				ko00000,ko00001,ko01000,ko03400				Bacteria	1MUYQ@1224,1RMHU@1236,3XNCU@561,COG0177@1,COG0177@2	NA|NA|NA	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C1_01547	316407.1742690	3.1e-119	434.5	Escherichia	rnfE	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0044464,GO:0055114,GO:0071944	2.3.1.243,4.2.99.18	ko:K02560,ko:K03613,ko:K10773	ko00540,ko01100,ko03410,map00540,map01100,map03410	M00060	R05075	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005,ko03400			iHN637.CLJU_RS05585	Bacteria	1MW6N@1224,1RMEH@1236,3XN79@561,COG4660@1,COG4660@2	NA|NA|NA	C	Part of a membrane complex involved in electron transport. Required to maintain the reduced state of SoxR
C1_01548	316407.1742689	4.8e-111	407.1	Escherichia	rnfG	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009279,GO:0016020,GO:0016491,GO:0016651,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0055114,GO:0071944		ko:K03612,ko:K03613					ko00000				Bacteria	1RDEP@1224,1RPAD@1236,3XM3D@561,COG4659@1,COG4659@2	NA|NA|NA	C	Part of a membrane complex involved in electron transport. Required to maintain the reduced state of SoxR
C1_01549	469008.B21_01590	1.8e-198	698.4	Escherichia	rnfD	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0044464,GO:0055114,GO:0071944	1.6.5.8	ko:K00347,ko:K03614					ko00000,ko01000				Bacteria	1MVY6@1224,1RMEU@1236,3XP8K@561,COG4658@1,COG4658@2	NA|NA|NA	C	Part of a membrane complex involved in electron transport. Required to maintain the reduced state of SoxR
C1_01550	481805.EcolC_2000	0.0	1082.8	Escherichia	rnfC	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0055114		ko:K03615					ko00000				Bacteria	1QTUI@1224,1RMIM@1236,3XPF3@561,COG4656@1,COG4656@2	NA|NA|NA	C	Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily
C1_01551	155864.EDL933_2583	3e-99	367.9	Escherichia	rnfB	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0055114	1.12.98.1	ko:K00441,ko:K03616	ko00680,ko01100,ko01120,map00680,map01100,map01120		R03025	RC02628	ko00000,ko00001,ko01000				Bacteria	1MUWU@1224,1RNSJ@1236,3XPHR@561,COG2878@1,COG2878@2	NA|NA|NA	C	Part of a membrane complex involved in electron transport. Required to maintain the reduced state of SoxR
C1_01552	1440052.EAKF1_ch4424c	2.5e-93	348.2	Escherichia	rnfA	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0044464,GO:0055114,GO:0071944		ko:K03617					ko00000				Bacteria	1MU8X@1224,1RQDN@1236,3XMS7@561,COG4657@1,COG4657@2	NA|NA|NA	C	Part of a membrane complex involved in electron transport. Required to maintain the reduced state of SoxR
C1_01553	199310.c2018	1.4e-72	278.9	Escherichia	ydgK	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1RCYV@1224,1S3X8@1236,29D1G@1,2ZZZI@2,3XPNB@561	NA|NA|NA	S	Protein of unknown function (DUF2569)
C1_01554	155864.EDL933_2580	5.2e-33	146.4	Escherichia	cnu	GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031554,GO:0043243,GO:0043244,GO:0043900,GO:0043901,GO:0045893,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0060566,GO:0065007,GO:0080090,GO:1900190,GO:1900191,GO:1900231,GO:1900232,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141											Bacteria	1MZM3@1224,1S9B1@1236,2CN5N@1,32S5U@2,3XPYY@561	NA|NA|NA	K	Hha and Cnu (YdgT) increase the number of genes bound by H-NS StpA and may also modulate the oligomerization of the H-NS StpA-complex on DNA. The complex formed with H-NS binds to the specific 26-bp cnb site in the origin of replication oriC
C1_01555	155864.EDL933_2578	5.4e-200	703.4	Escherichia	ydgJ		1.1.1.371	ko:K16044	ko00562,ko01120,map00562,map01120		R09954	RC00182	ko00000,ko00001,ko01000				Bacteria	1MU8F@1224,1RNKY@1236,3XPCD@561,COG0673@1,COG0673@2	NA|NA|NA	S	oxidoreductase activity
C1_01556	316407.1742677	4.3e-186	657.1	Escherichia	add	GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009156,GO:0009161,GO:0009163,GO:0009164,GO:0009165,GO:0009167,GO:0009168,GO:0009987,GO:0015949,GO:0015950,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0019637,GO:0032261,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0043173,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340		R01560,R02556	RC00477	ko00000,ko00001,ko01000			iSFV_1184.SFV_1640,iSF_1195.SF1648,iSFxv_1172.SFxv_1849,iS_1188.S1780	Bacteria	1MWBV@1224,1RNVI@1236,3XMUY@561,COG1816@1,COG1816@2	NA|NA|NA	F	Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily
C1_01557	316407.1742676	2.8e-229	800.8	Escherichia	malY	GO:0003674,GO:0003824,GO:0004121,GO:0005488,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016829,GO:0016846,GO:0019219,GO:0019222,GO:0019842,GO:0030170,GO:0031323,GO:0031326,GO:0036094,GO:0043167,GO:0043168,GO:0043433,GO:0044092,GO:0048037,GO:0048519,GO:0050662,GO:0050789,GO:0050794,GO:0051090,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0065009,GO:0070279,GO:0080090,GO:0080146,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	4.4.1.8	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230		R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007			iEC042_1314.EC042_1790,iECIAI1_1343.ECIAI1_1673,iECO103_1326.ECO103_1762,iECSE_1348.ECSE_1743,iECW_1372.ECW_m1788,iEKO11_1354.EKO11_2154,iEcE24377_1341.EcE24377A_1830,iWFL_1372.ECW_m1788	Bacteria	1MY33@1224,1RP58@1236,3XNTB@561,COG1168@1,COG1168@2	NA|NA|NA	E	maltose regulon
C1_01558	199310.c2013	5e-298	1029.6	Escherichia	malX	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009758,GO:0016020,GO:0044464,GO:0071944	2.7.1.192,2.7.1.193,2.7.1.199,2.7.1.201,2.7.1.208	ko:K02755,ko:K02756,ko:K02757,ko:K02778,ko:K02779,ko:K02790,ko:K02791,ko:K02802,ko:K02803,ko:K02804,ko:K02818,ko:K02819,ko:K11191,ko:K11192,ko:K20117,ko:K20118	ko00010,ko00500,ko00520,ko02060,ko05111,map00010,map00500,map00520,map02060,map05111	M00265,M00266,M00267,M00270,M00271,M00303,M00809	R02738,R02780,R04111,R05199,R08559	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.1.1,4.A.1.1.13,4.A.1.1.14,4.A.1.1.15,4.A.1.1.2,4.A.1.1.3,4.A.1.1.5,4.A.1.1.7,4.A.1.1.9,4.A.1.2.11,4.A.1.2.13,4.A.1.2.2,4.A.1.2.4,4.A.1.2.5,4.A.1.2.6,4.A.1.2.7,4.A.1.2.8		iECABU_c1320.ECABU_c48060,iECIAI39_1322.ECIAI39_2574,iECNA114_1301.ECNA114_1668,iECP_1309.ECP_0691,iECSF_1327.ECSF_1482,ic_1306.c5339	Bacteria	1MU2P@1224,1RNF4@1236,3XPA9@561,COG1263@1,COG1263@2,COG1264@1,COG1264@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in maltose transport. MalX can also recognize and transport glucose even though this sugar may not represent the natural substrate of the system
C1_01559	155864.EDL933_2574	3.4e-186	657.5	Escherichia	malI	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K02529,ko:K16136					ko00000,ko03000				Bacteria	1MXUS@1224,1RQFT@1236,3XMGE@561,COG1609@1,COG1609@2	NA|NA|NA	K	Maltose regulon Regulatory protein malI
C1_01560	155864.EDL933_2573	2.1e-137	495.0	Escherichia													Bacteria	1MUFX@1224,1RSP4@1236,3XPH9@561,COG1028@1,COG1028@2	NA|NA|NA	IQ	7-alpha-dehydroxylation of cholic acid, yielding deoxycholic acid and lithocholic acid, respectively. Highest affinity with taurochenodeoxycholic acid
C1_01561	155864.EDL933_2572	3.9e-99	367.5	Escherichia	uidR	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K16138					ko00000,ko03000				Bacteria	1RARJ@1224,1SXZ7@1236,3XQ9Q@561,COG1309@1,COG1309@2	NA|NA|NA	K	HTH-type transcriptional regulator UidR
C1_01562	316407.1742671	0.0	1264.6	Escherichia	uidA	GO:0003674,GO:0003824,GO:0004553,GO:0004566,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016043,GO:0016052,GO:0016054,GO:0016137,GO:0016139,GO:0016787,GO:0016798,GO:0019389,GO:0019391,GO:0019752,GO:0022607,GO:0042802,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901135,GO:1901136,GO:1901575,GO:1901657,GO:1901658	3.2.1.31	ko:K01195	ko00040,ko00531,ko00860,ko00944,ko00983,ko01100,ko01110,ko04142,map00040,map00531,map00860,map00944,map00983,map01100,map01110,map04142	M00014,M00076,M00077,M00078,M00129	R01478,R04979,R07818,R08127,R08260,R10830	RC00055,RC00171,RC00529,RC00530,RC00714,RC01251	ko00000,ko00001,ko00002,ko01000				Bacteria	1MVBN@1224,1RMER@1236,3XQ7T@561,COG3250@1,COG3250@2	NA|NA|NA	G	Belongs to the glycosyl hydrolase 2 family
C1_01563	155864.EDL933_2569	1.4e-251	875.2	Escherichia	uidB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03292,ko:K11104,ko:K16139					ko00000,ko02000	2.A.2,2.A.2.1		iBWG_1329.BWG_3833,iECDH10B_1368.ECDH10B_4312,iECDH1ME8569_1439.ECDH1ME8569_3979,iEKO11_1354.EKO11_4199,iEcDH1_1363.EcDH1_3872	Bacteria	1MVUM@1224,1RP5J@1236,3XQ9K@561,COG2211@1,COG2211@2	NA|NA|NA	G	MFS/sugar transport protein
C1_01564	316407.85675043	1.8e-242	844.7	Escherichia	uidC	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944		ko:K16140					ko00000,ko02000	1.B.25.1.5			Bacteria	1MY6H@1224,1RRGX@1236,2DBSC@1,2ZARH@2,3XQPN@561	NA|NA|NA	M	Enhances the activity of the UidB (GusB) glucuronide transporter, on its own however it has no transport activity. Glucuronide transport does not occur in strain K12 due to a variant at position 100 of the UidB (GusB, AC P0CE44, AC P0CE45) protein
C1_01565	481805.EcolC_2016	2.9e-279	967.2	Escherichia	ydgA	GO:0003674,GO:0005488,GO:0005515,GO:0042802											Bacteria	1MYKE@1224,1RRAU@1236,3XM7K@561,COG5339@1,COG5339@2	NA|NA|NA	S	identical protein binding
C1_01566	481805.EcolC_2017	3.1e-220	770.8	Escherichia	manA	GO:0000032,GO:0000271,GO:0003674,GO:0003824,GO:0004476,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005996,GO:0006013,GO:0006056,GO:0006057,GO:0006139,GO:0006464,GO:0006486,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009226,GO:0009242,GO:0009298,GO:0009987,GO:0016051,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019309,GO:0019318,GO:0019320,GO:0019438,GO:0019538,GO:0019673,GO:0031506,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0036211,GO:0042546,GO:0043170,GO:0043412,GO:0043413,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046377,GO:0046483,GO:0055086,GO:0070085,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	1.14.13.81,5.3.1.8,5.4.2.8	ko:K01809,ko:K01840,ko:K04035	ko00051,ko00520,ko00860,ko01100,ko01110,ko01130,map00051,map00520,map00860,map01100,map01110,map01130	M00114	R01818,R01819,R06265,R06266,R06267,R10068	RC00376,RC00408,RC00741,RC01491,RC01492,RC03042	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_696,iECOK1_1307.ECOK1_1731,iECS88_1305.ECS88_1659,iSFV_1184.SFV_1629,iSF_1195.SF1636,iSFxv_1172.SFxv_1833,iS_1188.S1767,iUMN146_1321.UM146_09090,iUTI89_1310.UTI89_C1801	Bacteria	1MUD8@1224,1RQX8@1236,3XN57@561,COG1482@1,COG1482@2	NA|NA|NA	G	mannose-6-phosphate isomerase
C1_01567	481805.EcolC_2018	0.0	1110.5	Escherichia	fumA	GO:0003674,GO:0003824,GO:0004333,GO:0005488,GO:0005515,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016860,GO:0016862,GO:0016999,GO:0017144,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0048037,GO:0050163,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350	4.2.1.2,4.2.1.32	ko:K01676,ko:K01677,ko:K01678,ko:K03780	ko00020,ko00620,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00630,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00339,R01082	RC00443,RC01382	ko00000,ko00001,ko00002,ko01000			iEC55989_1330.EC55989_1778,iPC815.YPO3335,iSBO_1134.SBO_2920	Bacteria	1MUV9@1224,1RN8U@1236,3XNKC@561,COG1838@1,COG1838@2,COG1951@1,COG1951@2	NA|NA|NA	C	Catalyzes the reversible hydration of fumarate to (S)- malate. Functions as an aerobic enzyme in the direction of malate formation as part of the citric acid cycle. Accounts for about 80 of the fumarase activity when the bacteria grow aerobically. To a lesser extent, also displays D-tartrate dehydratase activity in vitro, but is not able to convert (R)-malate, L-tartrate or meso- tartrate. Can also catalyze the isomerization of enol- to keto- oxaloacetate
C1_01568	155864.EDL933_2563	1.7e-265	921.4	Escherichia	fumC	GO:0003674,GO:0003824,GO:0004333,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0050896,GO:0055114,GO:0071704,GO:0072350	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000				Bacteria	1MUQI@1224,1RNUS@1236,3XN3G@561,COG0114@1,COG0114@2	NA|NA|NA	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
C1_01569	198214.SF1633	4.5e-174	617.1	Gammaproteobacteria	tus	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006274,GO:0006275,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008156,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010556,GO:0010558,GO:0010605,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0034641,GO:0034645,GO:0043111,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0060255,GO:0065007,GO:0071704,GO:0071807,GO:0080090,GO:0090304,GO:0090329,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:2000104,GO:2000112,GO:2000113		ko:K10748					ko00000,ko03032				Bacteria	1NE22@1224,1RS77@1236,28I61@1,2Z895@2	NA|NA|NA	L	Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence
C1_01570	316407.1742648	1.3e-246	858.6	Escherichia													Bacteria	1N9SU@1224,1RMF5@1236,3XN6Q@561,COG0642@1,COG2205@2	NA|NA|NA	T	PhoQ Sensor
C1_01571	316407.1742647	1.1e-130	472.6	Escherichia													Bacteria	1Q2S0@1224,1RQZZ@1236,3XMQA@561,COG0745@1,COG0745@2	NA|NA|NA	K	transcriptional Regulatory protein
C1_01572	155864.EDL933_2559	1.6e-52	211.8	Escherichia	ydgC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02442					ko00000				Bacteria	1RH8C@1224,1S69X@1236,3XPPD@561,COG3136@1,COG3136@2	NA|NA|NA	S	GlpM protein
C1_01573	155864.EDL933_2558	6.1e-134	483.4	Escherichia													Bacteria	1MUUV@1224,1RPGM@1236,3XP7I@561,COG1028@1,COG1028@2	NA|NA|NA	IQ	Catalyzes the reduction of dihydromonapterin to tetrahydromonapterin. Also has lower activity with dihydrofolate
C1_01574	198214.SF1626	9.9e-250	869.0	Gammaproteobacteria	ydgI	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K03758					ko00000,ko02000	2.A.3.2		iAPECO1_1312.APECO1_688,iECOK1_1307.ECOK1_1723,iECS88_1305.ECS88_1650,iUMN146_1321.UM146_09140,iUTI89_1310.UTI89_C1793	Bacteria	1MUA2@1224,1RNND@1236,COG0531@1,COG0531@2	NA|NA|NA	E	Arginine ornithine antiporter
C1_01575	155864.EDL933_2556	9.9e-169	599.4	Escherichia	ydgH												Bacteria	1MWCS@1224,1RN42@1236,28I6Q@1,2Z89M@2,3XN7G@561	NA|NA|NA	S	Protein of unknown function (DUF1471)
C1_01576	199310.c1995	5e-279	966.5	Escherichia	pntA	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006740,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008746,GO:0008750,GO:0009117,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016652,GO:0019362,GO:0019637,GO:0031224,GO:0031226,GO:0034641,GO:0036094,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0046483,GO:0046496,GO:0046983,GO:0048037,GO:0050661,GO:0050662,GO:0051186,GO:0051287,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072524,GO:0097159,GO:1901265,GO:1901360,GO:1901363,GO:1901564	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100		R00112	RC00001	ko00000,ko00001,ko01000			iEcE24377_1341.EcE24377A_1810	Bacteria	1MVXU@1224,1RN23@1236,3XMK7@561,COG3288@1,COG3288@2	NA|NA|NA	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C1_01577	155864.EDL933_2553	3.1e-251	874.0	Escherichia	pntB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006740,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008746,GO:0008750,GO:0009117,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016652,GO:0019362,GO:0019637,GO:0031224,GO:0031226,GO:0034641,GO:0036094,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050661,GO:0050662,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072524,GO:0097159,GO:1901265,GO:1901360,GO:1901363,GO:1901564	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100		R00112	RC00001	ko00000,ko00001,ko01000			iSBO_1134.SBO_1534,iYL1228.KPN_01527	Bacteria	1MUP4@1224,1RMR4@1236,3XN49@561,COG1282@1,COG1282@2	NA|NA|NA	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C1_01578	198214.SF1622	3.1e-171	607.8	Gammaproteobacteria	tqsA	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0009372,GO:0009987,GO:0015562,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0044764,GO:0051179,GO:0051234,GO:0051704,GO:0055085,GO:0071944		ko:K03548,ko:K11744					ko00000,ko02000	2.A.86.1			Bacteria	1MXXU@1224,1RQCM@1236,COG0628@1,COG0628@2	NA|NA|NA	T	permease
C1_01579	155864.EDL933_2551	2.8e-55	221.1	Escherichia	mdtJ	GO:0003674,GO:0005215,GO:0005326,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006836,GO:0008150,GO:0008324,GO:0008519,GO:0015075,GO:0015101,GO:0015199,GO:0015203,GO:0015220,GO:0015291,GO:0015297,GO:0015606,GO:0015651,GO:0015695,GO:0015696,GO:0015697,GO:0015838,GO:0015846,GO:0015848,GO:0015871,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0031460,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0072349,GO:0072488,GO:0098655,GO:1902047,GO:1903711		ko:K11743		M00711			ko00000,ko00002,ko02000	2.A.7.1.9		iAPECO1_1312.APECO1_683,iB21_1397.B21_01559,iBWG_1329.BWG_1415,iEC042_1314.EC042_1748,iEC55989_1330.EC55989_1765,iECBD_1354.ECBD_2046,iECB_1328.ECB_01569,iECDH10B_1368.ECDH10B_1733,iECDH1ME8569_1439.ECDH1ME8569_1543,iECD_1391.ECD_01569,iECED1_1282.ECED1_1769,iECH74115_1262.ECH74115_2310,iECIAI1_1343.ECIAI1_1650,iECNA114_1301.ECNA114_1647,iECO111_1330.ECO111_2069,iECO26_1355.ECO26_2304,iECOK1_1307.ECOK1_1718,iECP_1309.ECP_1544,iECS88_1305.ECS88_1645,iECSE_1348.ECSE_1721,iECSF_1327.ECSF_1460,iECSP_1301.ECSP_2164,iECW_1372.ECW_m1765,iECs_1301.ECs2306,iEKO11_1354.EKO11_2178,iETEC_1333.ETEC_1634,iEcDH1_1363.EcDH1_2043,iEcE24377_1341.EcE24377A_1807,iEcHS_1320.EcHS_A1674,iEcSMS35_1347.EcSMS35_1599,iEcolC_1368.EcolC_2030,iG2583_1286.G2583_1994,iJO1366.b1600,iLF82_1304.LF82_1301,iNRG857_1313.NRG857_08015,iSBO_1134.SBO_1536,iSDY_1059.SDY_1553,iSFV_1184.SFV_1615,iSF_1195.SF1621,iSFxv_1172.SFxv_1817,iSSON_1240.SSON_1560,iS_1188.S1753,iSbBS512_1146.SbBS512_E1786,iUMN146_1321.UM146_09165,iUMNK88_1353.UMNK88_2059,iUTI89_1310.UTI89_C1788,iWFL_1372.ECW_m1765,iY75_1357.Y75_RS08390,iZ_1308.Z2594	Bacteria	1RJKJ@1224,1S6SR@1236,3XPT1@561,COG2076@1,COG2076@2	NA|NA|NA	P	Catalyzes the excretion of spermidine
C1_01580	155864.EDL933_2550	1.1e-50	205.7	Escherichia	mdtI	GO:0003674,GO:0005215,GO:0005326,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006836,GO:0008150,GO:0008324,GO:0008519,GO:0015075,GO:0015101,GO:0015199,GO:0015203,GO:0015220,GO:0015291,GO:0015297,GO:0015606,GO:0015651,GO:0015695,GO:0015696,GO:0015697,GO:0015838,GO:0015846,GO:0015848,GO:0015871,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0031460,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0072349,GO:0072488,GO:0098655,GO:1902047,GO:1903711		ko:K03297,ko:K11742		M00711			ko00000,ko00002,ko02000	2.A.7.1,2.A.7.1.9			Bacteria	1RIBK@1224,1S68D@1236,3XPW5@561,COG2076@1,COG2076@2	NA|NA|NA	P	Catalyzes the excretion of spermidine
C1_01581	155864.EDL933_2549	7.6e-157	559.7	Escherichia	ydgD			ko:K04775					ko00000,ko01000,ko01002				Bacteria	1PDS4@1224,1RQNX@1236,3XN03@561,COG3591@1,COG3591@2	NA|NA|NA	E	Belongs to the peptidase S1B family
C1_01582	469008.B21_01556	7.3e-28	129.8	Escherichia	asr	GO:0005575,GO:0005623,GO:0008150,GO:0010035,GO:0010038,GO:0010043,GO:0042221,GO:0042597,GO:0044464,GO:0050896											Bacteria	1MZXN@1224,1S9PA@1236,2DHUV@1,32U9T@2,3XQ0P@561	NA|NA|NA	S	Required for growth and or survival at acidic conditions
C1_01583	316407.1742630	7.9e-214	749.6	Escherichia	ynfM	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K08224					ko00000,ko02000	2.A.1.36			Bacteria	1MWFH@1224,1RPAT@1236,3XNEU@561,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
C1_01584	155864.EDL933_2546	2.8e-165	587.8	Escherichia	ynfL	GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141											Bacteria	1MXRP@1224,1RQP1@1236,3XNTE@561,COG0583@1,COG0583@2	NA|NA|NA	K	transcriptional regulator
C1_01585	155864.EDL933_2545	1.8e-226	791.6	Escherichia	mlc	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576		ko:K02565,ko:K15545					ko00000,ko03000				Bacteria	1MX6M@1224,1RNZ1@1236,3XMPM@561,COG1940@1,COG1940@2	NA|NA|NA	K	Transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. Regulates the expression of malT
C1_01586	155864.EDL933_2544	2.2e-125	454.9	Escherichia	bioD	GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.3.3	ko:K01935	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03182	RC00868	ko00000,ko00001,ko00002,ko01000				Bacteria	1NPX5@1224,1RRRI@1236,3XMEG@561,COG0132@1,COG0132@2	NA|NA|NA	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C1_01587	469008.B21_01551	4.5e-225	786.9	Escherichia	clcB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03281					ko00000	2.A.49		iECH74115_1262.ECH74115_2303,iECP_1309.ECP_1536,iECSP_1301.ECSP_2156,iECW_1372.ECW_m1757,iG2583_1286.G2583_1986,iWFL_1372.ECW_m1757	Bacteria	1MV4K@1224,1RQZQ@1236,3XN0X@561,COG0038@1,COG0038@2	NA|NA|NA	P	Probably acts as an electrical shunt for an outwardly- directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response
C1_01588	155864.EDL933_2541	1.3e-116	425.6	Escherichia	dmsD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0009898,GO:0016020,GO:0019897,GO:0019898,GO:0031234,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098552,GO:0098562											Bacteria	1RF2Y@1224,1S3Q8@1236,3XMUD@561,COG3381@1,COG3381@2	NA|NA|NA	S	Required for biogenesis assembly of DMSO reductase, but not for the interaction of the DmsA signal peptide with the Tat system. May be part of a chaperone cascade complex that facilitates a folding-maturation pathway for the substrate protein
C1_01589	316407.85675037	1.1e-153	549.3	Escherichia	dmsC	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009389,GO:0009390,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016667,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0055114,GO:0071944,GO:1902494		ko:K07308,ko:K07312	ko00920,map00920		R09501	RC02555	ko00000,ko00001,ko02000	5.A.3.3		iE2348C_1286.E2348C_1674,iECNA114_1301.ECNA114_1636,iECO103_1326.ECO103_1729,iECO111_1330.ECO111_0964,iECO26_1355.ECO26_1022,iECSF_1327.ECSF_1450	Bacteria	1PA8U@1224,1RRGH@1236,3XQCX@561,COG3302@1,COG3302@2	NA|NA|NA	S	Dmso reductase anchor subunit
C1_01590	155864.EDL933_2539	2.2e-124	451.4	Escherichia	dmsB			ko:K07307,ko:K07311	ko00920,map00920		R09501	RC02555	ko00000,ko00001,ko02000	5.A.3.3		iPC815.YPO3324	Bacteria	1MU5T@1224,1RPIC@1236,3XQV9@561,COG0437@1,COG0437@2	NA|NA|NA	C	Electron transfer subunit of the terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds
C1_01591	316407.85675036	0.0	1636.7	Gammaproteobacteria	ynfF	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009390,GO:0009897,GO:0009986,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0022900,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0032991,GO:0033797,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071944,GO:0098552,GO:0098567,GO:1902494	1.8.5.3,1.97.1.9	ko:K07306,ko:K07309,ko:K07310	ko00450,ko00920,map00450,map00920		R07229,R09501	RC02420,RC02555	ko00000,ko00001,ko01000,ko02000	5.A.3.3		iE2348C_1286.E2348C_1672,iECSE_1348.ECSE_0952,iNRG857_1313.NRG857_07945	Bacteria	1NR6J@1224,1RMVE@1236,COG0243@1,COG0243@2	NA|NA|NA	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C1_01592	316407.1742610	0.0	1630.9	Gammaproteobacteria	ynfE	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009390,GO:0009897,GO:0009986,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0022900,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0032991,GO:0033797,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071944,GO:0098552,GO:0098567,GO:1902494	1.8.5.3,1.97.1.9	ko:K07306,ko:K07309,ko:K07310	ko00450,ko00920,map00450,map00920		R07229,R09501	RC02420,RC02555	ko00000,ko00001,ko01000,ko02000	5.A.3.3		iE2348C_1286.E2348C_1672,iECSE_1348.ECSE_0952,iNRG857_1313.NRG857_07945	Bacteria	1NR6J@1224,1RMVE@1236,COG0243@1,COG0243@2	NA|NA|NA	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C1_01593	316407.85675035	1.2e-46	192.2	Escherichia	ynfD												Bacteria	1N0CU@1224,1S9NS@1236,2CTGV@1,32STG@2,3XPU3@561	NA|NA|NA	S	Protein of unknown function (DUF1161)
C1_01594	198214.SF1595	1.2e-137	495.7	Gammaproteobacteria	ynfC												Bacteria	1R524@1224,1RQH0@1236,28IUM@1,2Z8TA@2	NA|NA|NA	M	Uncharacterised protein family (UPF0257)
C1_01595	155864.EDL933_2534	3.3e-103	380.9	Escherichia	speG	GO:0000287,GO:0003674,GO:0003824,GO:0004145,GO:0005488,GO:0005515,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009056,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0022607,GO:0034641,GO:0042402,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0046872,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901564,GO:1901565,GO:1901575	2.3.1.57	ko:K00657	ko00330,ko01100,ko04216,map00330,map01100,map04216	M00135	R01154	RC00004,RC00096	ko00000,ko00001,ko00002,ko01000			iAF1260.b1584,iB21_1397.B21_01543,iBWG_1329.BWG_1398,iECBD_1354.ECBD_2062,iECB_1328.ECB_01553,iECDH10B_1368.ECDH10B_1717,iECDH1ME8569_1439.ECDH1ME8569_1527,iECD_1391.ECD_01553,iECH74115_1262.ECH74115_2293,iECIAI1_1343.ECIAI1_1634,iECO103_1326.ECO103_1723,iECO111_1330.ECO111_2051,iECSE_1348.ECSE_1705,iECSP_1301.ECSP_2148,iECW_1372.ECW_m1749,iECs_1301.ECs2290,iEKO11_1354.EKO11_2194,iETEC_1333.ETEC_1618,iEcDH1_1363.EcDH1_2059,iEcE24377_1341.EcE24377A_1791,iEcHS_1320.EcHS_A1657,iEcolC_1368.EcolC_2046,iG2583_1286.G2583_1978,iJO1366.b1584,iJR904.b1584,iWFL_1372.ECW_m1749,iY75_1357.Y75_RS08305,iZ_1308.Z2571	Bacteria	1PDMH@1224,1RPZ4@1236,3XMEZ@561,COG1670@1,COG1670@2	NA|NA|NA	J	Involved in the protection against polyamine toxicity by regulating their concentration. Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to the primary amino groups of spermidine to yield N(1)- and N(8)-acetylspermidine
C1_01596	198214.SF1593	9.1e-56	222.6	Gammaproteobacteria	ynfB	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944											Bacteria	1N0YE@1224,1S9BH@1236,2CSJ8@1,32SRB@2	NA|NA|NA	S	Belongs to the UPF0482 family
C1_01597	316407.85675031	1.8e-53	214.9	Escherichia	ynfA	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K09771					ko00000,ko02000	2.A.7.26			Bacteria	1MZI8@1224,1SA4U@1236,3XPXU@561,COG1742@1,COG1742@2	NA|NA|NA	S	Uncharacterised BCR, YnfA/UPF0060 family
C1_01598	316407.1742582	1.7e-245	854.7	Escherichia	rspA	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0008150,GO:0008152,GO:0008927,GO:0009056,GO:0016052,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043169,GO:0044238,GO:0046872,GO:0071704,GO:1901575	4.2.1.8	ko:K08323	ko00040,ko01100,map00040,map01100	M00061	R05606	RC00543	ko00000,ko00001,ko00002,ko01000				Bacteria	1MURK@1224,1RNRB@1236,3XP82@561,COG4948@1,COG4948@2	NA|NA|NA	M	Has low D-mannonate dehydratase activity (in vitro), suggesting that this is not a physiological substrate and that it has no significant role in D-mannonate degradation in vivo. Has no detectable activity with a panel of 70 other acid sugars (in vitro)
C1_01599	469008.B21_01539	6.3e-193	679.9	Escherichia	rspB		1.1.1.380	ko:K08322	ko00040,ko01100,map00040,map01100		R10848	RC00085	ko00000,ko00001,ko01000			iYO844.BSU12330	Bacteria	1MWX0@1224,1SYGT@1236,3XQPI@561,COG1063@1,COG1063@2	NA|NA|NA	C	zinc ion binding
C1_01600	481805.EcolC_2051	3.9e-12	76.3	Bacteria				ko:K18926		M00715			ko00000,ko00002,ko02000	2.A.1.3.30			Bacteria	COG0477@1,COG0477@2	NA|NA|NA	EGP	Major facilitator Superfamily
C1_01601	481805.EcolC_2052	4.7e-246	856.7	Escherichia				ko:K03733,ko:K14059					ko00000,ko03036				Bacteria	1MVZB@1224,1RP4Y@1236,3XM9F@561,COG0582@1,COG0582@2	NA|NA|NA	L	Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome (By similarity)
C1_01602	1440052.EAKF1_ch4476c	7e-39	166.0	Escherichia													Bacteria	1QR63@1224,1RU0Q@1236,2CQE5@1,31TFQ@2,3XRBM@561	NA|NA|NA	S	Putative excisionase (DUF1233)
C1_01603	481805.EcolC_2054	0.0	1596.3	Gammaproteobacteria			2.7.7.7	ko:K02342,ko:K09951,ko:K10906	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03400				Bacteria	1R9YS@1224,1S23K@1236,COG0847@1,COG0847@2	NA|NA|NA	L	3' exoribonuclease, RNase T-like
C1_01604	511145.b1576	4.2e-26	123.2	Escherichia		GO:0001906,GO:0001907,GO:0008150,GO:0016032,GO:0019048,GO:0019058,GO:0019076,GO:0031640,GO:0035821,GO:0035890,GO:0035891,GO:0039633,GO:0040011,GO:0044003,GO:0044004,GO:0044364,GO:0044403,GO:0044419,GO:0044659,GO:0044661,GO:0051701,GO:0051704,GO:0051817,GO:0051818,GO:0051883,GO:0052126,GO:0052192											Bacteria	1NIY5@1224,1SHDX@1236,2EHIM@1,33BAK@2,3XR7I@561	NA|NA|NA	S	Protein of unknown function (DUF1482)
C1_01605	316407.1742576	6.4e-27	125.9	Escherichia	dicB	GO:0008150,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051302,GO:0051782,GO:0065007		ko:K22304					ko00000				Bacteria	1QIQA@1224,1TGJM@1236,2AV4R@1,31KUY@2,3XR7H@561	NA|NA|NA	D	Division inhibition protein dicB
C1_01606	316407.1742574	4.9e-09	68.2	Escherichia													Bacteria	1QIRK@1224,1TGKY@1236,2DK2U@1,3089M@2,3XRAA@561	NA|NA|NA		
C1_01607	1440052.EAKF1_ch0488	6.2e-20	102.4	Escherichia	ydfA												Bacteria	1NCTS@1224,1SEZR@1236,2E72D@1,331M0@2,3XR6X@561	NA|NA|NA	S	Protein of unknown function (DUF1391)
C1_01608	630626.EBL_c20860	5.5e-40	170.6	Gammaproteobacteria	dicA	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576		ko:K22300					ko00000,ko03000				Bacteria	1N2U8@1224,1SBKZ@1236,COG1396@1,COG1396@2	NA|NA|NA	K	helix-turn-helix domain protein
C1_01609	155864.EDL933_1971	1.4e-23	115.2	Escherichia				ko:K22302					ko00000,ko03000				Bacteria	1N9GJ@1224,1SEUE@1236,2ECMR@1,336JR@2,3XR3B@561	NA|NA|NA	D	DNA-binding transcriptional regulator Cro
C1_01610	481805.EcolC_2060	1.2e-91	342.4	Escherichia	ydfX												Bacteria	1NA33@1224,1SG50@1236,2EE2H@1,337X7@2,3XQ92@561	NA|NA|NA	S	Putative bacterial toxin ydaT
C1_01611	469008.B21_01527	1.2e-182	645.6	Escherichia	ybl78												Bacteria	1RC7A@1224,1S388@1236,3XQJS@561,COG3935@1,COG3935@2	NA|NA|NA	L	DnaD domain protein
C1_01612	481805.EcolC_2062	2.4e-63	248.1	Gammaproteobacteria													Bacteria	1RD4K@1224,1S3VY@1236,29XZ3@1,30JRR@2	NA|NA|NA	S	Bacterial protein of unknown function (DUF977)
C1_01613	1313304.CALK_2497	1.7e-142	513.5	Bacteria													Bacteria	COG4694@1,COG4694@2	NA|NA|NA		
C1_01614	316407.1742557	9.9e-18	95.1	Escherichia	hokD	GO:0005575,GO:0008150,GO:0008219,GO:0009987,GO:0016020		ko:K18919					ko00000,ko02048				Bacteria	1ND6M@1224,1SFSG@1236,2DQ3V@1,334M8@2,3XR9G@561	NA|NA|NA	S	When overexpressed kills the cells from the inside by interfering with a vital function in the cell membrane
C1_01615	316407.1742556	8.2e-38	162.5	Escherichia	rem												Bacteria	1NYHP@1224,1SQGD@1236,2FA95@1,342HU@2,3XR76@561	NA|NA|NA		
C1_01616	481805.EcolC_2076	3.2e-200	704.1	Escherichia	ydfU												Bacteria	1N0FM@1224,1RP42@1236,3XQGJ@561,COG1403@1,COG1403@2	NA|NA|NA	V	Corresponds to locus_tag
C1_01617	316407.1742554	4.4e-143	513.8	Escherichia	quuQ												Bacteria	1QHJU@1224,1RQCY@1236,3XPWT@561,COG0484@1,COG0484@2	NA|NA|NA	K	Antitermination protein Q
C1_01618	316407.1742552	1.4e-33	148.3	Gammaproteobacteria	cspA	GO:0001072,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003723,GO:0003727,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008143,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043242,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051087,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0060567,GO:0065007,GO:0070717,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K03704					ko00000,ko03000			iECW_1372.ECW_m0678,iWFL_1372.ECW_m0678	Bacteria	1N6Q5@1224,1SCA7@1236,COG1278@1,COG1278@2	NA|NA|NA	K	Cold shock
C1_01619	316407.85675023	7.2e-32	142.5	Escherichia	essQ	GO:0001906,GO:0001907,GO:0008150,GO:0016032,GO:0019048,GO:0019058,GO:0019076,GO:0031640,GO:0035821,GO:0035890,GO:0035891,GO:0039633,GO:0040011,GO:0044003,GO:0044004,GO:0044364,GO:0044403,GO:0044419,GO:0044659,GO:0044661,GO:0051701,GO:0051704,GO:0051817,GO:0051818,GO:0051883,GO:0052126,GO:0052192											Bacteria	1NAY0@1224,1SBWM@1236,2E3SS@1,32YQ9@2,3XRH5@561	NA|NA|NA	S	Lysis protein S homolog from lambdoid prophage
C1_01620	502347.ESCAB7627_1257	2.4e-26	124.8	Escherichia	ydfR												Bacteria	1P4ZI@1224,1SUPV@1236,2DEGM@1,2ZMXP@2,3XR1P@561	NA|NA|NA	S	Protein of unknown function (DUF1327)
C1_01621	316407.85675021	1.6e-102	378.6	Escherichia	rrrQ	GO:0001906,GO:0001907,GO:0003674,GO:0003796,GO:0003824,GO:0004553,GO:0008150,GO:0016032,GO:0016787,GO:0016798,GO:0019048,GO:0019058,GO:0019076,GO:0031640,GO:0035821,GO:0035890,GO:0035891,GO:0039633,GO:0040011,GO:0044003,GO:0044004,GO:0044364,GO:0044403,GO:0044419,GO:0044659,GO:0044661,GO:0051701,GO:0051704,GO:0051817,GO:0051818,GO:0051883,GO:0052126,GO:0052192,GO:0061783	3.2.1.17	ko:K01185					ko00000,ko01000				Bacteria	1RA0W@1224,1S2XG@1236,3XQB7@561,COG3772@1,COG3772@2	NA|NA|NA	G	Corresponds to locus_tag
C1_01622	316407.85675020	4.8e-82	310.5	Gammaproteobacteria													Bacteria	1RIWH@1224,1S7QI@1236,2EDZZ@1,31C0Y@2	NA|NA|NA	S	Protein of unknown function (DUF2514)
C1_01623	199310.c3177	6.1e-34	149.4	Escherichia	cspA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006950,GO:0008150,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141		ko:K03704					ko00000,ko03000				Bacteria	1N6Q5@1224,1SCA7@1236,3XQ03@561,COG1278@1,COG1278@2	NA|NA|NA	K	Binds to and stimulates the transcription of the CCAAT- containing, cold-shock-inducible promoters of the H-NS and GyrA proteins. Binds also to the inverted repeat 5'-ATTGG-3'
C1_01624	316407.85675018	2.2e-21	107.5	Gammaproteobacteria	gnsB	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0042802,GO:0044424,GO:0044444,GO:0044464											Bacteria	1NEUJ@1224,1SFD3@1236,2BVP3@1,332DR@2	NA|NA|NA	S	Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation
C1_01625	155864.EDL933_1822	2.4e-63	248.1	Bacteria	ybcV												Bacteria	COG5562@1,COG5562@2	NA|NA|NA	E	phage envelope protein
C1_01628	343509.SG1232	1.6e-43	182.6	Gammaproteobacteria													Bacteria	1R7DT@1224,1S1TV@1236,28MTZ@1,2ZB20@2	NA|NA|NA	S	Protein of unknown function (DUF1441)
C1_01629	414970.A5LH27_9CAUD	0.0	1432.9	Siphoviridae		GO:0005575,GO:0008150,GO:0016032,GO:0018995,GO:0019058,GO:0019068,GO:0019072,GO:0019073,GO:0030430,GO:0032991,GO:0033643,GO:0033646,GO:0043493,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044403,GO:0044419,GO:0051704,GO:0098009,GO:1902494,GO:1904949											Viruses	4QAXX@10239,4QMAG@10699,4QPTB@28883,4QV9W@35237	NA|NA|NA	S	Phage terminase large subunit (GpA)
C1_01630	155864.EDL933_0870	6.3e-31	139.4	Escherichia													Bacteria	1NHBE@1224,1SHUZ@1236,2EJB8@1,33D2C@2,3XRDG@561	NA|NA|NA		
C1_01631	414970.A5LH29_9CAUD	1.3e-287	995.0	Caudovirales		GO:0005575,GO:0019012,GO:0019028,GO:0032991,GO:0044423,GO:0046798											Viruses	4QAZJ@10239,4QPFF@28883,4QX3R@35237	NA|NA|NA	S	Phage portal protein, lambda family
C1_01632	1147152.K7PGT6_9CAUD	0.0	1274.2	Siphoviridae													Viruses	4QBNM@10239,4QKV6@10699,4QPUI@28883	NA|NA|NA	S	Clp protease
C1_01633	155864.EDL933_0874	5.4e-50	203.4	Gammaproteobacteria													Bacteria	1NE9H@1224,1SDYV@1236,COG5471@1,COG5471@2	NA|NA|NA	S	Uncharacterized conserved protein (DUF2190)
C1_01634	155864.EDL933_0875	2.9e-44	184.1	Escherichia													Bacteria	1N8Z6@1224,1SDG9@1236,2E4T0@1,32ZMD@2,3XRB9@561	NA|NA|NA	S	ATP-binding sugar transporter from pro-phage
C1_01635	155864.EDL933_0876	6.6e-99	366.7	Escherichia													Bacteria	1R6UI@1224,1S10J@1236,295PD@1,2ZT0R@2,3XPQS@561	NA|NA|NA	S	prophage
C1_01636	155864.EDL933_0877	7.6e-70	269.6	Gammaproteobacteria													Bacteria	1RK18@1224,1S7AX@1236,2AFU1@1,315WD@2	NA|NA|NA	S	Phage minor tail protein U
C1_01637	155864.EDL933_0878	2.3e-128	464.9	Escherichia													Bacteria	1R7SX@1224,1RP1Q@1236,3XPJR@561,COG5492@1,COG5492@2	NA|NA|NA	N	Corresponds to locus_tag
C1_01638	155864.EDL933_0879	1.6e-64	251.9	Gammaproteobacteria													Bacteria	1N0TF@1224,1S9RH@1236,2EBXR@1,32VXR@2	NA|NA|NA	S	Bacteriophage lambda tail assembly chaperone, TAC, protein G
C1_01639	198214.SF0712	2.2e-54	218.0	Gammaproteobacteria													Bacteria	1NCN9@1224,1SCN0@1236,2E7G2@1,331YY@2	NA|NA|NA	S	phage tail assembly protein T
C1_01640	155864.EDL933_0881	0.0	1654.8	Gammaproteobacteria	sca1												Bacteria	1MU81@1224,1RS6P@1236,COG1196@1,COG1196@2,COG5281@1,COG5281@2	NA|NA|NA	D	tail length tape measure
C1_01641	155864.EDL933_0882	5.5e-58	229.9	Escherichia													Bacteria	1N8H3@1224,1SCEF@1236,3XQ54@561,COG4718@1,COG4718@2	NA|NA|NA	S	Phage minor tail protein
C1_01642	414970.A5LH40_9CAUD	5.5e-132	476.9	Siphoviridae		GO:0005575,GO:0008150,GO:0016032,GO:0018995,GO:0019012,GO:0019058,GO:0019068,GO:0030430,GO:0033643,GO:0033646,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044403,GO:0044419,GO:0051704,GO:0098003											Viruses	4QC9C@10239,4QKMD@10699,4QPG4@28883,4QW2U@35237	NA|NA|NA	S	Phage minor tail protein L
C1_01643	1147152.K7PLW1_9CAUD	7.3e-117	426.4	Siphoviridae		GO:0005575,GO:0018995,GO:0030430,GO:0033643,GO:0033646,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217											Viruses	4QAK6@10239,4QKKV@10699,4QPBY@28883,4QUP9@35237	NA|NA|NA	S	peptidoglycan catabolic process
C1_01644	1440052.EAKF1_ch0448c	2.6e-89	334.7	Escherichia													Bacteria	1RFBS@1224,1S4AY@1236,3XRHR@561,COG4723@1,COG4723@2	NA|NA|NA	S	Bacteriophage lambda tail assembly protein I
C1_01645	1147152.K7PKJ2_9CAUD	0.0	2228.0	dsDNA viruses, no RNA stage													Viruses	4QUYQ@35237	NA|NA|NA		
C1_01646	155864.EDL933_1845	9.6e-109	399.4	Gammaproteobacteria	ompX			ko:K07804,ko:K11934	ko02020,map02020				ko00000,ko00001,ko02000	1.B.6.2.1			Bacteria	1RH8M@1224,1SE1S@1236,COG3637@1,COG3637@2	NA|NA|NA	M	Corresponds to locus_tag
C1_01647	155864.EDL933_1849	6.1e-156	558.5	Escherichia	stfR												Bacteria	1RFCQ@1224,1S5SP@1236,3XQHT@561,COG5301@1,COG5301@2	NA|NA|NA	M	tail fiber protein
C1_01648	316407.1742546	1.3e-102	379.0	Escherichia	lppD	GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0008150,GO:0008428,GO:0009892,GO:0010605,GO:0016020,GO:0016787,GO:0019213,GO:0019219,GO:0019222,GO:0019899,GO:0030234,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0043086,GO:0043900,GO:0044092,GO:0044464,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060698,GO:0060699,GO:0060700,GO:0060701,GO:0060702,GO:0061463,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0098772,GO:1900190,GO:1900231											Bacteria	1MYT5@1224,1S7KD@1236,3XPJT@561,COG2110@1,COG2110@2	NA|NA|NA	S	Tail fiber assembly protein homolog from lambdoid prophage
C1_01649	199310.c3146	2.2e-102	378.3	Escherichia	pinR	GO:0000150,GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140097,GO:1901360		ko:K14060					ko00000				Bacteria	1RA0V@1224,1RPSK@1236,3XR8X@561,COG1961@1,COG1961@2	NA|NA|NA	L	recombinase activity
C1_01650	316407.85675015	1.2e-35	155.2	Gammaproteobacteria	ydfK	GO:0003674,GO:0005215,GO:0005216,GO:0005261,GO:0005267,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006950,GO:0008150,GO:0008324,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015267,GO:0015318,GO:0015672,GO:0016020,GO:0022803,GO:0022838,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0044464,GO:0046873,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098660,GO:0098662											Bacteria	1N9CF@1224,1SFBX@1236,2E5B9@1,3303D@2	NA|NA|NA	K	response to cold
C1_01651	316407.1742544	6.4e-235	819.7	Escherichia	ydfJ	GO:0003333,GO:0003674,GO:0005215,GO:0005216,GO:0005261,GO:0005267,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006820,GO:0006865,GO:0006950,GO:0006970,GO:0006972,GO:0007154,GO:0007165,GO:0007231,GO:0008028,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0008519,GO:0009628,GO:0009651,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015079,GO:0015101,GO:0015199,GO:0015267,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015530,GO:0015651,GO:0015652,GO:0015653,GO:0015672,GO:0015695,GO:0015696,GO:0015697,GO:0015711,GO:0015718,GO:0015733,GO:0015804,GO:0015824,GO:0015838,GO:0015849,GO:0015850,GO:0016020,GO:0016021,GO:0022803,GO:0022804,GO:0022838,GO:0022857,GO:0022890,GO:0023052,GO:0030001,GO:0031224,GO:0031226,GO:0031460,GO:0033554,GO:0034220,GO:0035524,GO:0042538,GO:0043090,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0046942,GO:0046943,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0065007,GO:0071214,GO:0071470,GO:0071472,GO:0071474,GO:0071475,GO:0071702,GO:0071705,GO:0071804,GO:0071805,GO:0071944,GO:0072337,GO:0072349,GO:0072488,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098660,GO:0098662,GO:0098739,GO:0104004,GO:1901618,GO:1902600,GO:1903825,GO:1905039,GO:1905647		ko:K03761,ko:K03762,ko:K08172,ko:K08173					ko00000,ko02000	2.A.1.6,2.A.1.6.2,2.A.1.6.4,2.A.1.6.6		e_coli_core.b2587,iAF1260.b2587,iAPECO1_1312.APECO1_1067,iB21_1397.B21_02445,iBWG_1329.BWG_2351,iEC55989_1330.EC55989_2218,iEC55989_1330.EC55989_2877,iECBD_1354.ECBD_1093,iECB_1328.ECB_02481,iECDH10B_1368.ECDH10B_2755,iECDH1ME8569_1439.ECDH1ME8569_2514,iECD_1391.ECD_02481,iECIAI1_1343.ECIAI1_2705,iECIAI39_1322.ECIAI39_2795,iECNA114_1301.ECNA114_2055,iECO103_1326.ECO103_3166,iECO111_1330.ECO111_3313,iECO26_1355.ECO26_3634,iECS88_1305.ECS88_2049,iECW_1372.ECW_m2816,iEKO11_1354.EKO11_1146,iETEC_1333.ETEC_2800,iEcDH1_1363.EcDH1_1081,iEcE24377_1341.EcE24377A_2873,iEcolC_1368.EcolC_1090,iJO1366.b2587,iJR904.b2587,iLF82_1304.LF82_2131,iNRG857_1313.NRG857_09945,iSBO_1134.SBO_2619,iSDY_1059.SDY_2830,iSF_1195.SF2649,iSFxv_1172.SFxv_2906,iS_1188.S2822,iUMNK88_1353.UMNK88_3239,iUTI89_1310.UTI89_C4705,iWFL_1372.ECW_m2816,iY75_1357.Y75_RS13520,ic_1306.c5116	Bacteria	1MU46@1224,1RNC9@1236,3XQW9@561,COG0477@1,COG0477@2	NA|NA|NA	P	Sugar (and other) transporter
C1_01652	198214.SF1553	3.4e-277	960.3	Gammaproteobacteria	mtlK	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0044424,GO:0044464,GO:0055114	1.1.1.17,1.1.1.289,1.1.1.57,1.1.1.58,1.1.1.67,2.7.1.17	ko:K00009,ko:K00040,ko:K00041,ko:K00045,ko:K00854,ko:K19633	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014,M00061,M00631	R00868,R01639,R02454,R02555,R02703,R07346	RC00002,RC00085,RC00102,RC00538	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_2108,iECABU_c1320.ECABU_c17480,iECOK1_1307.ECOK1_4822,iUMN146_1321.UM146_22300,iUTI89_1310.UTI89_C5019	Bacteria	1MVZ7@1224,1RNIZ@1236,COG0246@1,COG0246@2	NA|NA|NA	G	Belongs to the mannitol dehydrogenase family
C1_01653	1440052.EAKF1_ch4497c	1.9e-29	134.8	Escherichia	ydfZ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Bacteria	1NFFH@1224,1SG5K@1236,2C4ZZ@1,3308E@2,3XQ4X@561	NA|NA|NA	S	YdfZ protein
C1_01654	155864.EDL933_2093	2.1e-123	448.4	Escherichia	ydfH	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576		ko:K22293					ko00000,ko03000				Bacteria	1MWG2@1224,1RNYJ@1236,3XNRB@561,COG1802@1,COG1802@2	NA|NA|NA	K	transcriptional regulator
C1_01655	199310.c1965	5e-139	500.4	Escherichia	ydfG	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006208,GO:0006212,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0019860,GO:0031132,GO:0034641,GO:0035527,GO:0042737,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	1.1.1.381	ko:K16066	ko00240,ko00260,ko01100,map00240,map00260,map01100		R09289,R10851,R10852	RC00087,RC00525,RC03288	ko00000,ko00001,ko01000				Bacteria	1MUF8@1224,1RMKM@1236,3XNZ4@561,COG4221@1,COG4221@2	NA|NA|NA	S	NADP-dependent dehydrogenase with broad substrate specificity acting on 3-hydroxy acids. Catalyzes the NADP- dependent oxidation of L-allo-threonine to L-2-amino-3-keto- butyrate, which is spontaneously decarboxylated into aminoacetone. Also acts on D-threonine, L-serine, D-serine, D-3- hydroxyisobutyrate, L-3-hydroxyisobutyrate, D-glycerate and L- glycerate. Able to catalyze the reduction of the malonic semialdehyde to 3-hydroxypropionic acid. YdfG is apparently supplementing RutE, the presumed malonic semialdehyde reductase involved in pyrimidine degradation since both are able to detoxify malonic semialdehyde
C1_01656	155864.EDL933_2095	0.0	1363.6	Escherichia	dcp	GO:0003674,GO:0003824,GO:0004180,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0016787,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.15.5,3.4.24.70	ko:K01284,ko:K01414					ko00000,ko01000,ko01002				Bacteria	1MU1K@1224,1RMXI@1236,3XMH4@561,COG0339@1,COG0339@2	NA|NA|NA	E	metalloendopeptidase activity
C1_01657	155864.EDL933_2096	1.2e-86	325.9	Escherichia	cinA		3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760		R02322	RC00100	ko00000,ko00001,ko01000				Bacteria	1RBXS@1224,1S3AH@1236,3XRGG@561,COG1546@1,COG1546@2	NA|NA|NA	S	Competence-damaged protein
C1_01658	316407.1742519	7.7e-67	259.6	Escherichia	ydeI	GO:0000302,GO:0006950,GO:0006979,GO:0008150,GO:0009636,GO:0009987,GO:0010035,GO:0010038,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042710,GO:0044010,GO:0044011,GO:0044764,GO:0046677,GO:0046686,GO:0050896,GO:0051703,GO:0051704,GO:0051716,GO:0070301,GO:0070887,GO:0071236,GO:0071241,GO:0071248,GO:0071276,GO:0090605,GO:0090609,GO:0097237,GO:1901700,GO:1901701											Bacteria	1REUG@1224,1S54G@1236,3XQ1V@561,COG3111@1,COG3111@2	NA|NA|NA	S	single-species biofilm formation on inanimate substrate
C1_01659	316407.85675013	5.9e-171	606.7	Escherichia	ydeH	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0007155,GO:0008150,GO:0008270,GO:0009987,GO:0010639,GO:0016740,GO:0016772,GO:0016779,GO:0022610,GO:0031344,GO:0031345,GO:0031589,GO:0032879,GO:0033043,GO:0042710,GO:0042802,GO:0043167,GO:0043169,GO:0043708,GO:0043709,GO:0043900,GO:0043902,GO:0044010,GO:0044087,GO:0044464,GO:0044764,GO:0046872,GO:0046914,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051270,GO:0051271,GO:0051704,GO:0052621,GO:0060187,GO:0060491,GO:0065007,GO:0090605,GO:0090609,GO:1900190,GO:1900192,GO:1900231,GO:1900233,GO:1902115,GO:1902116,GO:1902208,GO:1902209	2.7.7.65	ko:K13069			R08057		ko00000,ko01000				Bacteria	1R7KA@1224,1RS1K@1236,3XMPS@561,COG2199@1,COG3706@2	NA|NA|NA	T	swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria
C1_01660	35703.DQ02_20540	2.3e-09	66.6	Citrobacter													Bacteria	1PKDA@1224,1TM2C@1236,2ETZ7@1,30YHR@2,3WZP9@544	NA|NA|NA		
C1_01661	469008.B21_01504	2.8e-213	747.7	Escherichia	ydeE	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008150,GO:0015833,GO:0016020,GO:0022857,GO:0035442,GO:0035672,GO:0035673,GO:0042886,GO:0042887,GO:0042938,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071916,GO:0071944,GO:1904680											Bacteria	1N0KT@1224,1RYZC@1236,3XMUC@561,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
C1_01662	199310.c1961	9.2e-156	556.2	Escherichia	eamA	GO:0000101,GO:0003333,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0008150,GO:0015562,GO:0015711,GO:0015804,GO:0015849,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0032973,GO:0033228,GO:0034220,GO:0042883,GO:0044425,GO:0044464,GO:0046942,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0098655,GO:0098656,GO:0140115,GO:1903712,GO:1903825,GO:1905039		ko:K03298,ko:K15268					ko00000,ko02000	2.A.7.3,2.A.7.3.2		iECIAI39_1322.ECIAI39_1835	Bacteria	1MVKG@1224,1RM8T@1236,3XP05@561,COG0697@1,COG0697@2	NA|NA|NA	EG	May be an export pump for cysteine and other metabolites of the cysteine pathway (such as N-acetyl-L-serine (NAS) and O- acetyl-L-serine (OAS)), and for other amino acids and their metabolites
C1_01663	199310.c1960	1.6e-126	458.8	Escherichia				ko:K03482,ko:K03710					ko00000,ko03000				Bacteria	1MUEB@1224,1RN2J@1236,3XQNX@561,COG2188@1,COG2188@2	NA|NA|NA	K	UTRA
C1_01664	199310.c1959	2.7e-46	191.0	Escherichia	gmuB_2		2.7.1.196,2.7.1.205	ko:K02760	ko00500,ko02060,map00500,map02060	M00275	R11170,R11172	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.3.2		iEC55989_1330.EC55989_1672,iECIAI1_1343.ECIAI1_1550,iECO103_1326.ECO103_1669,iECO111_1330.ECO111_1934,iECO26_1355.ECO26_2139,iECSE_1348.ECSE_1627,iECW_1372.ECW_m1666,iEKO11_1354.EKO11_2279,iWFL_1372.ECW_m1666	Bacteria	1RI62@1224,1S6QW@1236,3XQ4W@561,COG1440@1,COG1440@2	NA|NA|NA	G	PTS system, Lactose/Cellobiose specific IIB subunit
C1_01665	199310.c1958	9.8e-239	832.4	Escherichia	chbC			ko:K02761	ko00500,ko02060,map00500,map02060	M00275	R11170,R11172	RC00017,RC03206	ko00000,ko00001,ko00002,ko02000	4.A.3.2		iECABU_c1320.ECABU_c19930	Bacteria	1QR5I@1224,1RQKB@1236,3XPUU@561,COG1455@1,COG1455@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
C1_01666	199310.c1957	2.2e-48	198.0	Escherichia	celC		2.7.1.196,2.7.1.205	ko:K02759	ko00500,ko02060,map00500,map02060	M00275	R11170,R11172	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.3.2		iECABU_c1320.ECABU_c17610,iECOK1_1307.ECOK1_1683,iECUMN_1333.ECUMN_2025,iNRG857_1313.NRG857_07575,iUMN146_1321.UM146_09345	Bacteria	1N0T8@1224,1S73V@1236,3XRJY@561,COG1447@1,COG1447@2	NA|NA|NA	G	PTS system, Lactose/Cellobiose specific IIA subunit
C1_01667	199310.c1956	0.0	1075.1	Escherichia	bglH			ko:K02024,ko:K10124					ko00000,ko02000	1.B.3.1.1,1.B.3.1.3		iEC55989_1330.EC55989_1669,iEC55989_1330.EC55989_4527,iECIAI1_1343.ECIAI1_1547,iECSE_1348.ECSE_1624,iECW_1372.ECW_m1663,iEKO11_1354.EKO11_2282,iWFL_1372.ECW_m1663	Bacteria	1PNS3@1224,1RQTQ@1236,3XQB8@561,COG4580@1,COG4580@2	NA|NA|NA	G	Maltoporin periplasmic N-terminal extension
C1_01668	199310.c1955	2e-290	1004.2	Escherichia	bglA		3.2.1.86	ko:K01223	ko00010,ko00500,map00010,map00500		R00839,R05133,R05134	RC00049,RC00171,RC00714	ko00000,ko00001,ko01000		GT1	iSSON_1240.SSON_3054,iUTI89_1310.UTI89_C1752	Bacteria	1MWG6@1224,1RMM2@1236,3XMTE@561,COG2723@1,COG2723@2	NA|NA|NA	G	Glycosyl hydrolase family 1
C1_01669	481805.EcolC_2126	7.6e-32	142.5	Escherichia	marB	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464		ko:K13630					ko00000				Bacteria	1N7UE@1224,1SFHP@1236,2E68Q@1,330WV@2,3XQ6F@561	NA|NA|NA	S	response to antibiotic
C1_01670	155864.EDL933_2106	5.8e-67	260.0	Escherichia	soxS	GO:0000976,GO:0000984,GO:0000985,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0006081,GO:0006082,GO:0006089,GO:0006355,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009438,GO:0009635,GO:0009636,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010033,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019172,GO:0019219,GO:0019222,GO:0019243,GO:0019249,GO:0019752,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032787,GO:0032991,GO:0032993,GO:0035690,GO:0036245,GO:0042180,GO:0042182,GO:0042221,GO:0042493,GO:0042802,GO:0042803,GO:0043436,GO:0043565,GO:0044212,GO:0044237,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046185,GO:0046394,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051596,GO:0051716,GO:0060255,GO:0061727,GO:0065007,GO:0070887,GO:0071310,GO:0071704,GO:0072330,GO:0072756,GO:0080090,GO:0097159,GO:0097237,GO:0140110,GO:1901363,GO:1901562,GO:1901575,GO:1901576,GO:1901615,GO:1901617,GO:1901654,GO:1901655,GO:1901700,GO:1901701,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K05804,ko:K13631,ko:K13632,ko:K18325,ko:K19056	ko01503,map01503	M00647,M00746,M00767			ko00000,ko00001,ko00002,ko01504,ko03000,ko03036				Bacteria	1QWBW@1224,1T2T8@1236,3XRN2@561,COG4977@1,COG4977@2	NA|NA|NA	K	May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF
C1_01671	155864.EDL933_2107	2.9e-75	287.7	Escherichia	marR	GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042221,GO:0044212,GO:0045892,GO:0045934,GO:0046677,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0070887,GO:0071236,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K03712,ko:K15974		M00701			ko00000,ko00002,ko03000				Bacteria	1N7BV@1224,1S2AX@1236,3XMZ4@561,COG1846@1,COG1846@2	NA|NA|NA	K	Multiple antibiotic resistance protein MarR
C1_01672	198214.SF1565	3.9e-111	407.5	Gammaproteobacteria	marC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K05595					ko00000,ko02000	2.A.95.1			Bacteria	1MV1C@1224,1RPM8@1236,COG2095@1,COG2095@2	NA|NA|NA	U	UPF0056 membrane protein
C1_01673	316407.1742501	3.4e-206	724.2	Escherichia	sotB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03445,ko:K08159					ko00000,ko02000	2.A.1.2.15,2.A.1.2.18,2.A.1.2.26		iEcSMS35_1347.EcSMS35_1642,iSF_1195.SF1566	Bacteria	1MU9G@1224,1RPHV@1236,3XNX7@561,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
C1_01674	316407.85675008	1.9e-39	167.9	Escherichia	yneK												Bacteria	1NR5J@1224,1SJVZ@1236,2EWD9@1,33PRV@2,3XQHE@561	NA|NA|NA		
C1_01675	481805.EcolC_2131	5.2e-159	567.0	Escherichia	yneK												Bacteria	1NR5J@1224,1SJVZ@1236,2EWD9@1,33PRV@2,3XQHE@561	NA|NA|NA		
C1_01676	199310.c1949	5.3e-164	583.6	Escherichia	yneJ	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576											Bacteria	1N8HZ@1224,1RR4Z@1236,3XP0D@561,COG0583@1,COG0583@2	NA|NA|NA	K	Transcriptional regulator
C1_01677	316407.85675007	7.8e-263	912.5	Escherichia	sad	GO:0001505,GO:0003674,GO:0003824,GO:0004777,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008150,GO:0008152,GO:0009013,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009448,GO:0009450,GO:0009987,GO:0016054,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0032787,GO:0034641,GO:0042133,GO:0042135,GO:0042402,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:0072329,GO:0097164,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.2.1.16,1.2.1.20,1.2.1.24,1.2.1.79	ko:K00135,ko:K08324	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000			iECUMN_1333.ECUMN_1793	Bacteria	1MU1V@1224,1RMBQ@1236,3XNDH@561,COG1012@1,COG1012@2	NA|NA|NA	C	Catalyzes the NAD( )-dependent oxidation of succinate semialdehyde to succinate. It acts preferentially with NAD as cosubstrate but can also use NADP. Prevents the toxic accumulation of succinate semialdehyde (SSA) and plays an important role when arginine and putrescine are used as the sole nitrogen or carbon sources
C1_01678	155864.EDL933_2114	1.2e-171	609.0	Escherichia	glsA	GO:0003674,GO:0003824,GO:0004359,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006543,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009065,GO:0009084,GO:0009987,GO:0016053,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0040008,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0045926,GO:0046394,GO:0046395,GO:0048519,GO:0050789,GO:0065007,GO:0071704,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	3.5.1.2	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230		R00256,R01579	RC00010,RC02798	ko00000,ko00001,ko01000			iB21_1397.B21_01492,iECBD_1354.ECBD_2118,iECB_1328.ECB_01481,iECD_1391.ECD_01481,iYL1228.KPN_01636,iYO844.BSU02430	Bacteria	1MWB5@1224,1RMY9@1236,3XNTI@561,COG2066@1,COG2066@2	NA|NA|NA	E	Belongs to the glutaminase family
C1_01679	316407.85675006	7.3e-64	249.6	Escherichia	yneG												Bacteria	1RGW8@1224,1S6NK@1236,2DMJC@1,32RYJ@2,3XPTR@561	NA|NA|NA	S	Domain of unknown function (DUF4186)
C1_01680	155864.EDL933_2116	1.2e-261	908.7	Escherichia	yneF	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0032879,GO:0040012,GO:0044464,GO:0050789,GO:0050794,GO:0051270,GO:0065007,GO:0071944,GO:1902021,GO:2000145										ic_1306.c1945	Bacteria	1QU9S@1224,1T1QS@1236,3XM31@561,COG2199@1,COG2199@2	NA|NA|NA	T	diguanylate cyclase
C1_01681	316407.1742495	2.7e-282	977.2	Escherichia	uxaB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006063,GO:0006064,GO:0006082,GO:0008150,GO:0008152,GO:0008866,GO:0009026,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019585,GO:0019586,GO:0019698,GO:0019752,GO:0032787,GO:0036094,GO:0042839,GO:0042840,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046395,GO:0046396,GO:0046397,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575	1.1.1.17,1.1.1.57,1.1.1.58	ko:K00009,ko:K00040,ko:K00041	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00061,M00631	R02454,R02555,R02703	RC00085	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_2108,iECABU_c1320.ECABU_c17480,iECOK1_1307.ECOK1_4822,iUMN146_1321.UM146_22300,iUTI89_1310.UTI89_C5019	Bacteria	1MVZ7@1224,1RQX5@1236,3XM9T@561,COG0246@1,COG0246@2	NA|NA|NA	G	Belongs to the mannitol dehydrogenase family. UxaB subfamily
C1_01682	469008.B21_01488	1.8e-167	595.1	Escherichia	yneE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K08994					ko00000,ko02000	1.A.46.2			Bacteria	1MX91@1224,1S0QU@1236,3XM7T@561,COG3781@1,COG3781@2	NA|NA|NA	S	Bestrophin, RFP-TM, chloride channel
C1_01683	198214.SF1576	3.6e-145	520.8	Gammaproteobacteria	tam	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0030798,GO:0032259,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0051704	2.1.1.144,2.1.1.197	ko:K00598,ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000			iECABU_c1320.ECABU_c17460,iSDY_1059.SDY_1625,ic_1306.c1942	Bacteria	1Q2Y3@1224,1RPKV@1236,COG4106@1,COG4106@2	NA|NA|NA	S	Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate
C1_01684	155864.EDL933_2120	1.2e-48	198.7	Escherichia	lsrG	GO:0002952,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016853,GO:0044424,GO:0044444,GO:0044464,GO:0055114	5.3.1.32	ko:K11530	ko02024,map02024				ko00000,ko00001,ko01000				Bacteria	1RI7W@1224,1S61K@1236,3XR3S@561,COG1359@1,COG1359@2	NA|NA|NA	S	Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the conversion of (4S)-4-hydroxy-5- phosphonooxypentane-2,3-dione (P-DPD) to 3-hydroxy-5- phosphonooxypentane-2,4-dione (P-HPD)
C1_01685	481805.EcolC_2141	4.9e-162	577.0	Escherichia	lsrF	GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0016747	2.3.1.245,4.1.2.13	ko:K08321,ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko02024,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map02024	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000				Bacteria	1MWJW@1224,1RYC1@1236,3XQD5@561,COG1830@1,COG1830@2	NA|NA|NA	H	Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the transfer of an acetyl moiety from 3-hydroxy-5-phosphonooxypentane-2,4-dione to CoA to form glycerone phosphate and acetyl-CoA
C1_01686	155864.EDL933_2122	6.1e-188	663.3	Escherichia	lsrB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015749,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0034219,GO:0044425,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944		ko:K10555	ko02010,ko02024,map02010,map02024	M00219			ko00000,ko00001,ko00002,ko02000	3.A.1.2.8			Bacteria	1MUAT@1224,1RXX7@1236,3XPVP@561,COG1879@1,COG1879@2	NA|NA|NA	G	Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases
C1_01687	198214.SF1585	1.3e-171	609.0	Gammaproteobacteria	lsrD	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015749,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0034219,GO:0044425,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944		ko:K10557	ko02010,ko02024,map02010,map02024	M00219			ko00000,ko00001,ko00002,ko02000	3.A.1.2.8		iETEC_1333.ETEC_1585	Bacteria	1MV4F@1224,1RQ84@1236,COG1172@1,COG1172@2	NA|NA|NA	U	Belongs to the binding-protein-dependent transport system permease family
C1_01688	481805.EcolC_2144	3.2e-181	641.0	Escherichia	lsrC	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015749,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0034219,GO:0044425,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944		ko:K10556	ko02010,ko02024,map02010,map02024	M00219			ko00000,ko00001,ko00002,ko02000	3.A.1.2.8		iEKO11_1354.EKO11_2302,iPC815.YPO0411	Bacteria	1MWN4@1224,1RQFP@1236,3XQG6@561,COG1172@1,COG1172@2	NA|NA|NA	U	Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane
C1_01689	481805.EcolC_2145	2.7e-280	970.7	Escherichia	lsrA		3.6.3.17	ko:K10441,ko:K10558	ko02010,ko02024,map02010,map02024	M00212,M00219			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.8			Bacteria	1MU22@1224,1RPSU@1236,3XQS0@561,COG1129@1,COG1129@2	NA|NA|NA	G	Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Responsible for energy coupling to the transport system
C1_01690	198214.SF1582	1.4e-157	562.4	Gammaproteobacteria	lsrR	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:1990837,GO:2000112,GO:2000142,GO:2001141		ko:K11531	ko02024,ko02026,map02024,map02026				ko00000,ko00001,ko03000				Bacteria	1MWHQ@1224,1RRDZ@1236,COG2390@1,COG2390@2	NA|NA|NA	K	transcriptional regulator
C1_01691	316407.1742480	2.2e-309	1067.4	Escherichia	lsrK	GO:0000166,GO:0003674,GO:0003824,GO:0004856,GO:0005488,GO:0005524,GO:0005975,GO:0005996,GO:0005997,GO:0005998,GO:0006004,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0008737,GO:0008744,GO:0008993,GO:0009056,GO:0009372,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0019200,GO:0019299,GO:0019301,GO:0019317,GO:0019318,GO:0019320,GO:0019321,GO:0019323,GO:0019324,GO:0019566,GO:0019568,GO:0019571,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042354,GO:0042355,GO:0042710,GO:0042732,GO:0042843,GO:0043167,GO:0043168,GO:0044010,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044764,GO:0046365,GO:0046372,GO:0046835,GO:0051704,GO:0071518,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901575	2.7.1.17,2.7.1.189,2.7.1.5,2.7.1.51,2.7.1.53	ko:K00848,ko:K00854,ko:K00879,ko:K00880,ko:K11216	ko00040,ko00051,ko00053,ko01100,ko01120,ko02024,map00040,map00051,map00053,map01100,map01120,map02024	M00014	R01639,R01901,R01902,R03014,R03241,R07127,R11183	RC00002,RC00017,RC00538	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_2885,iB21_1397.B21_02615,iECB_1328.ECB_02654,iECD_1391.ECD_02654,iECOK1_1307.ECOK1_4011,iECP_1309.ECP_3667,iECS88_1305.ECS88_3982,iEcE24377_1341.EcE24377A_4435,iEcSMS35_1347.EcSMS35_3903,iUMN146_1321.UM146_17990,iUTI89_1310.UTI89_C4105	Bacteria	1MWS5@1224,1RRKR@1236,3XQXQ@561,COG1070@1,COG1070@2	NA|NA|NA	G	Catalyzes the phosphorylation of autoinducer-2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of (S)-4,5-dihydroxypentane-2,3- dione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position
C1_01692	316407.85674997	1.7e-159	568.5	Escherichia	hipA	GO:0000166,GO:0000287,GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0003824,GO:0004672,GO:0004674,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0008144,GO:0008150,GO:0008152,GO:0009279,GO:0009297,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0015267,GO:0015288,GO:0015473,GO:0016020,GO:0016043,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018105,GO:0018193,GO:0018209,GO:0019219,GO:0019222,GO:0019538,GO:0019867,GO:0022607,GO:0022611,GO:0022803,GO:0022829,GO:0022857,GO:0030030,GO:0030031,GO:0030312,GO:0030313,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031975,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0032993,GO:0035639,GO:0036094,GO:0036211,GO:0036289,GO:0042710,GO:0043086,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043565,GO:0043711,GO:0044010,GO:0044085,GO:0044092,GO:0044212,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044462,GO:0044464,GO:0044764,GO:0045892,GO:0045934,GO:0046777,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051179,GO:0051234,GO:0051252,GO:0051253,GO:0051704,GO:0055085,GO:0060255,GO:0065007,GO:0065009,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140096,GO:0140110,GO:1901265,GO:1901363,GO:1901564,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141	2.7.11.1	ko:K07154					ko00000,ko01000,ko01001,ko02048				Bacteria	1MVAB@1224,1RR5N@1236,3XQT8@561,COG3550@1,COG3550@2	NA|NA|NA	S	Toxic component of a type II toxin-antitoxin (TA) system, first identified by mutations that increase production of persister cells, a fraction of cells that are phenotypic variants not killed by antibiotics, which lead to multidrug tolerance. Persistence may be ultimately due to global remodeling of the persister cell's ribosomes. Phosphorylates Glu-tRNA-ligase (AC P04805, gltX, on 'Ser-239') in vivo. Phosphorylation of GltX prevents it from being charged, leading to an increase in uncharged tRNA(Glu). This induces amino acid starvation and the stringent response via RelA SpoT and increased (p)ppGpp levels, which inhibits replication, transcription, translation and cell wall synthesis, reducing growth and leading to persistence and multidrug resistance. Once the level of HipA exceeds a threshold cells become dormant, and the length of dormancy is determined by how much HipA levels exceed the threshold. The hipA7 mutation (a double G22S D291A mutation) leads to increased generation of persister cells (cells that survive antibiotic treatment) probably by entering into a dormant state, as well as cold-sensitivity. Wild-type cells produce persisters at a frequency of 10(-6) to 10(-5) whereas hipA7 cells produce about 100-fold more persisters. hipA7 decreases the affinity for antitoxin HipB, leading to increased HipA levels and persistence
C1_01693	155864.EDL933_2132	1.8e-93	348.6	Gammaproteobacteria	fimA			ko:K07345,ko:K07352	ko05133,map05133				ko00000,ko00001,ko02035,ko02044				Bacteria	1QI7Y@1224,1S07V@1236,COG3539@1,COG3539@2	NA|NA|NA	NU	Fimbrial protein
C1_01694	155864.EDL933_2133	2.4e-127	461.5	Gammaproteobacteria				ko:K07346,ko:K07353,ko:K15540					ko00000,ko02035,ko02044,ko03110				Bacteria	1R3T9@1224,1RS56@1236,COG3121@1,COG3121@2	NA|NA|NA	M	chaperone
C1_01695	199310.c1934	0.0	1686.8	Escherichia	ydeT	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0009279,GO:0009297,GO:0009987,GO:0015267,GO:0015288,GO:0015473,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0022803,GO:0022829,GO:0022857,GO:0030030,GO:0030031,GO:0030312,GO:0030313,GO:0031975,GO:0043711,GO:0044085,GO:0044462,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071840,GO:0071944		ko:K07347	ko05133,map05133				ko00000,ko00001,ko02000,ko02035,ko02044	1.B.11.3			Bacteria	1MUHE@1224,1RMPU@1236,3XMHU@561,COG3188@1,COG3188@2	NA|NA|NA	NU	Outer membrane usher protein fimD
C1_01696	155864.EDL933_2135	1.1e-92	345.9	Gammaproteobacteria	ydeS			ko:K07348					ko00000,ko02035,ko02044				Bacteria	1N7VK@1224,1T0XP@1236,COG3539@1,COG3539@2	NA|NA|NA	NU	Fimbrial protein
C1_01697	199310.c1932	5.6e-86	323.6	Escherichia	ydeR			ko:K07349					ko00000,ko02035,ko02044				Bacteria	1RC12@1224,1S36F@1236,3XRCJ@561,COG3539@1,COG3539@2	NA|NA|NA	NU	cell adhesion
C1_01698	155864.EDL933_2137	3.5e-171	607.4	Gammaproteobacteria	ydeQ			ko:K07350					ko00000,ko02035,ko02044				Bacteria	1RCUS@1224,1S3EA@1236,COG3539@1,COG3539@2	NA|NA|NA	NU	cell adhesion
C1_01699	316407.1742462	0.0	1518.1	Escherichia	ydeP	GO:0008150,GO:0009268,GO:0009628,GO:0010447,GO:0050896											Bacteria	1MU6B@1224,1RNXW@1236,3XNYR@561,COG0243@1,COG0243@2	NA|NA|NA	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C1_01700	1440052.EAKF1_ch0283	1.5e-59	235.3	Escherichia	insC			ko:K07483					ko00000				Bacteria	1N0V0@1224,1S7WV@1236,3XRHH@561,COG2963@1,COG2963@2	NA|NA|NA	L	transposase activity
C1_01701	199310.c3611	1.9e-172	611.7	Escherichia		GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576		ko:K07483,ko:K07497					ko00000				Bacteria	1MY62@1224,1RQSR@1236,3XQHU@561,COG2801@1,COG2801@2	NA|NA|NA	L	DNA integration
C1_01703	155864.EDL933_2140	2.7e-140	504.6	Escherichia	ydeO	GO:0003674,GO:0003700,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141		ko:K03755,ko:K11920,ko:K21905,ko:K21906					ko00000,ko03000				Bacteria	1NNF1@1224,1SI85@1236,3XR55@561,COG2207@1,COG2207@2	NA|NA|NA	K	Induces the expression of gadE and mdtEF. Could also regulate the expression of other genes involved in acid resistance
C1_01704	316407.85674993	0.0	1135.9	Escherichia	ydeN	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464		ko:K01138					ko00000,ko01000				Bacteria	1MV92@1224,1RPM3@1236,3XNAG@561,COG3119@1,COG3119@2	NA|NA|NA	P	sulfuric ester hydrolase activity
C1_01705	316407.1742455	2.1e-229	801.2	Escherichia	ydeM	GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0019538,GO:0033554,GO:0043170,GO:0044238,GO:0050896,GO:0051604,GO:0051716,GO:0071704,GO:1901564		ko:K06871					ko00000				Bacteria	1MX3M@1224,1RN4R@1236,3XP4I@561,COG0641@1,COG0641@2	NA|NA|NA	C	protein maturation
C1_01706	481805.EcolC_2161	0.0	1102.8	Escherichia	yddA	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0016021,GO:0017076,GO:0030554,GO:0031224,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044425,GO:0044464,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K02471	ko02010,map02010				ko00000,ko00001,ko02000	3.A.1.203.11,3.A.1.203.4			Bacteria	1MW09@1224,1RPQA@1236,3XQG7@561,COG4178@1,COG4178@2	NA|NA|NA	P	ATPase activity, coupled to movement of substances
C1_01707	316407.1742453	0.0	1594.7	Escherichia	yddB												Bacteria	1MXAE@1224,1RWWH@1236,3XQNT@561,COG1629@1,COG4771@2	NA|NA|NA	P	TonB-dependent Receptor Plug Domain
C1_01708	481805.EcolC_2163	0.0	1782.7	Escherichia	pqqL	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K07263					ko00000,ko01000,ko01002				Bacteria	1NAH6@1224,1RNKC@1236,3XQWU@561,COG0612@1,COG0612@2	NA|NA|NA	S	Belongs to the peptidase M16 family
C1_01709	362663.ECP_1489	2e-282	977.6	Escherichia	gadA	GO:0003674,GO:0003824,GO:0004351,GO:0006873,GO:0006885,GO:0008150,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0019725,GO:0030003,GO:0030004,GO:0030641,GO:0042592,GO:0045852,GO:0048878,GO:0050801,GO:0051453,GO:0051454,GO:0055067,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0098771	4.1.1.15	ko:K01580	ko00250,ko00410,ko00430,ko00650,ko01100,ko01110,ko01120,ko02024,ko04727,ko04940,map00250,map00410,map00430,map00650,map01100,map01110,map01120,map02024,map04727,map04940	M00027	R00261,R00489,R01682,R02466	RC00299	ko00000,ko00001,ko00002,ko01000			iAF1260.b3517,iE2348C_1286.E2348C_3759,iECDH1ME8569_1439.ECDH1ME8569_3396,iECUMN_1333.ECUMN_1747,iEcDH1_1363.EcDH1_0196,iEcolC_1368.EcolC_0200,iJO1366.b3517,iJR904.b3517,iUTI89_1310.UTI89_C1707,ic_1306.c1922	Bacteria	1MX25@1224,1RNSQ@1236,3XMMA@561,COG0076@1,COG0076@2	NA|NA|NA	E	Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria
C1_01710	198214.SF1735	2.7e-280	970.7	Gammaproteobacteria	gadC	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0006873,GO:0006885,GO:0008150,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015171,GO:0015179,GO:0015291,GO:0015297,GO:0015318,GO:0015711,GO:0015807,GO:0015849,GO:0016020,GO:0016021,GO:0019725,GO:0022804,GO:0022857,GO:0030003,GO:0030004,GO:0030641,GO:0031224,GO:0031226,GO:0034220,GO:0042592,GO:0044425,GO:0044459,GO:0044464,GO:0045852,GO:0046942,GO:0046943,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0051453,GO:0051454,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:0098771,GO:1902475,GO:1903825,GO:1905039		ko:K20265	ko02024,map02024				ko00000,ko00001,ko02000	2.A.3.7.1,2.A.3.7.3		iEC042_1314.EC042_1624	Bacteria	1MUP1@1224,1RR0V@1236,COG0531@1,COG0531@2	NA|NA|NA	E	amino acid
C1_01711	155864.EDL933_2149	3.4e-260	903.7	Escherichia	yddW			ko:K11931	ko02026,map02026				ko00000,ko00001,ko01000				Bacteria	1N99Y@1224,1RSIV@1236,3XM34@561,COG1649@1,COG1649@2	NA|NA|NA	S	catalytic activity
C1_01712	469008.B21_01461	1e-254	885.6	Escherichia	dosC	GO:0003674,GO:0003824,GO:0005488,GO:0008144,GO:0016740,GO:0016772,GO:0016779,GO:0019825,GO:0020037,GO:0036094,GO:0042165,GO:0043167,GO:0043169,GO:0046906,GO:0048037,GO:0052621,GO:0070025,GO:0097159,GO:1901363	2.7.7.65	ko:K13069			R08057		ko00000,ko01000				Bacteria	1MVCZ@1224,1RS2H@1236,3XN9P@561,COG2199@1,COG3706@2	NA|NA|NA	T	Globin-coupled heme-based oxygen sensor protein displaying diguanylate cyclase (DGC) activity in response to oxygen availability. Thus, catalyzes the synthesis of cyclic diguanylate (c-di-GMP) via the condensation of 2 GTP molecules
C1_01713	316407.1742440	0.0	1587.0	Escherichia	dosP	GO:0000287,GO:0003674,GO:0003824,GO:0004112,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008081,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009628,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019825,GO:0019826,GO:0020037,GO:0034641,GO:0034654,GO:0036094,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046390,GO:0046483,GO:0046872,GO:0046906,GO:0048037,GO:0050896,GO:0052652,GO:0052653,GO:0055086,GO:0070482,GO:0071111,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	3.1.4.52	ko:K13243			R08991	RC00296	ko00000,ko01000			iG2583_1286.G2583_1852	Bacteria	1NWNJ@1224,1T2J6@1236,3XN8P@561,COG2199@1,COG2199@2,COG2200@1,COG2200@2,COG2202@1,COG2202@2	NA|NA|NA	T	Heme-based oxygen sensor protein displaying phosphodiesterase (PDE) activity toward c-di-GMP in response to oxygen availability. Involved in the modulation of intracellular c-di-GMP levels, in association with DosC which catalyzes the biosynthesis of c-di-GMP (diguanylate cyclase activity). Cyclic- di-GMP is a second messenger which controls cell surface- associated traits in bacteria. Has very poor PDE activity on cAMP but is not active with cGMP, bis(p-nitrophenyl) phosphate or p-nitrophenyl phosphate. Via its PDE activity on c-di-GMP, DosP regulates biofilm formation through the repression of transcription of the csgBAC operon, which encodes curli structural subunits
C1_01714	155864.EDL933_2153	5.1e-37	159.8	Gammaproteobacteria	ddpX	GO:0003674,GO:0003824,GO:0004180,GO:0004181,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009046,GO:0009605,GO:0009991,GO:0016787,GO:0019538,GO:0031667,GO:0042594,GO:0043170,GO:0044238,GO:0050896,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.13.22	ko:K07282,ko:K08641	ko01502,ko02020,map01502,map02020	M00651			ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504				Bacteria	1RENK@1224,1S3SJ@1236,COG2173@1,COG2173@2	NA|NA|NA	M	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
C1_01715	316407.85674987	4e-300	1036.6	Gammaproteobacteria	ddpA	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464		ko:K02035	ko02024,map02024	M00239			ko00000,ko00001,ko00002,ko02000	3.A.1.5		iB21_1397.B21_01457,iECBD_1354.ECBD_2152,iECB_1328.ECB_01445,iECD_1391.ECD_01445	Bacteria	1MUZH@1224,1RR8J@1236,COG0747@1,COG0747@2	NA|NA|NA	E	Extracellular solute-binding protein, family 5
C1_01716	316407.1742426	9.1e-192	676.0	Escherichia	ddpB	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K02033	ko02024,map02024	M00239			ko00000,ko00001,ko00002,ko02000	3.A.1.5		iECIAI39_1322.ECIAI39_1750,iECSP_1301.ECSP_1971,iZ_1308.Z2224	Bacteria	1MU8Z@1224,1RNJ1@1236,3XMU4@561,COG0601@1,COG0601@2	NA|NA|NA	EP	probably responsible for the translocation of the substrate across the membrane
C1_01717	155864.EDL933_2156	1.4e-159	568.9	Escherichia	ddpC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K02034,ko:K12370,ko:K13891,ko:K15582,ko:K15586	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00324,M00348,M00439,M00440			ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.11,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25		iAF1260.b1245,iAF1260.b3542,iAPECO1_1312.APECO1_2906,iB21_1397.B21_01229,iB21_1397.B21_03344,iBWG_1329.BWG_3231,iE2348C_1286.E2348C_3790,iEC042_1314.EC042_3848,iEC55989_1330.EC55989_1342,iEC55989_1330.EC55989_3993,iECABU_c1320.ECABU_c08730,iECABU_c1320.ECABU_c39840,iECBD_1354.ECBD_0194,iECBD_1354.ECBD_2377,iECB_1328.ECB_01219,iECB_1328.ECB_03393,iECDH10B_1368.ECDH10B_1307,iECDH10B_1368.ECDH10B_3721,iECDH1ME8569_1439.ECDH1ME8569_1185,iECDH1ME8569_1439.ECDH1ME8569_3422,iECD_1391.ECD_01219,iECD_1391.ECD_03393,iECED1_1282.ECED1_4221,iECH74115_1262.ECH74115_4910,iECIAI1_1343.ECIAI1_1264,iECIAI1_1343.ECIAI1_3700,iECIAI39_1322.ECIAI39_4051,iECNA114_1301.ECNA114_3693,iECO103_1326.ECO103_1345,iECO103_1326.ECO103_4274,iECO111_1330.ECO111_1572,iECO111_1330.ECO111_4358,iECO26_1355.ECO26_1756,iECO26_1355.ECO26_4636,iECOK1_1307.ECOK1_3988,iECP_1309.ECP_0846,iECP_1309.ECP_3643,iECS88_1305.ECS88_3962,iECSE_1348.ECSE_1293,iECSE_1348.ECSE_3815,iECSF_1327.ECSF_3376,iECSP_1301.ECSP_1637,iECSP_1301.ECSP_4533,iECUMN_1333.ECUMN_1542,iECUMN_1333.ECUMN_4052,iECW_1372.ECW_m1337,iECW_1372.ECW_m3808,iECs_1301.ECs1745,iECs_1301.ECs4422,iEKO11_1354.EKO11_0191,iEKO11_1354.EKO11_2607,iETEC_1333.ETEC_1347,iETEC_1333.ETEC_3787,iEcDH1_1363.EcDH1_0170,iEcDH1_1363.EcDH1_2403,iEcE24377_1341.EcE24377A_1393,iEcE24377_1341.EcE24377A_4034,iEcHS_1320.EcHS_A1354,iEcHS_1320.EcHS_A3741,iEcSMS35_1347.EcSMS35_3861,iEcolC_1368.EcolC_0173,iEcolC_1368.EcolC_2383,iG2583_1286.G2583_1517,iG2583_1286.G2583_4279,iJO1366.b1245,iJO1366.b3542,iLF82_1304.LF82_0517,iNRG857_1313.NRG857_17605,iSSON_1240.SSON_1935,iSbBS512_1146.SbBS512_E3843,iUMN146_1321.UM146_17880,iUMNK88_1353.UMNK88_1565,iUMNK88_1353.UMNK88_4323,iUTI89_1310.UTI89_C4080,iWFL_1372.ECW_m1337,iWFL_1372.ECW_m3808,iY75_1357.Y75_RS06515,iY75_1357.Y75_RS19465,iZ_1308.Z2021,iZ_1308.Z4959,ic_1306.c0917,ic_1306.c4357	Bacteria	1MW3R@1224,1RSEE@1236,3XRIN@561,COG1173@1,COG1173@2	NA|NA|NA	EP	Part of the ABC transporter complex DdpABCDF, which is probably involved in D,D-dipeptide transport. Probably responsible for the translocation of the substrate across the membrane
C1_01718	481805.EcolC_2173	1.4e-184	652.1	Escherichia	ddpD		3.6.3.24	ko:K02031,ko:K02032,ko:K12371,ko:K15583,ko:K15587	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00324,M00439,M00440			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25		iECIAI1_1343.ECIAI1_1494,iECIAI39_1322.ECIAI39_3960,iEcSMS35_1347.EcSMS35_3763,iSBO_1134.SBO_1821	Bacteria	1R4KB@1224,1SMBI@1236,3XMHZ@561,COG0444@1,COG0444@2	NA|NA|NA	P	Belongs to the ABC transporter superfamily
C1_01719	316407.1742423	7.2e-172	609.8	Gammaproteobacteria	ddpF	GO:0000166,GO:0003674,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008144,GO:0008150,GO:0009314,GO:0009628,GO:0015232,GO:0015886,GO:0016020,GO:0017076,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0050896,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901678		ko:K02032,ko:K10823,ko:K12372	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00324,M00439			ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25		iAPECO1_1312.APECO1_362,iEC042_1314.EC042_1615,iECH74115_1262.ECH74115_2095,iECOK1_1307.ECOK1_1402,iECS88_1305.ECS88_1315,iECSP_1301.ECSP_1968,iECUMN_1333.ECUMN_1737,iECW_1372.ECW_m1611,iECs_1301.ECs2087,iEKO11_1354.EKO11_2337,iSF_1195.SF3575,iSFxv_1172.SFxv_3897,iS_1188.S4195,iUMN146_1321.UM146_10835,iUTI89_1310.UTI89_C1445,iWFL_1372.ECW_m1611,iZ_1308.Z2227	Bacteria	1NU4K@1224,1RRVT@1236,COG4608@1,COG4608@2	NA|NA|NA	P	Belongs to the ABC transporter superfamily
C1_01720	198214.SF1743	1.1e-74	285.8	Gammaproteobacteria	osmC	GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006970,GO:0006972,GO:0006979,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0033194,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1990748		ko:K04063					ko00000				Bacteria	1RH9U@1224,1S205@1236,COG1764@1,COG1764@2	NA|NA|NA	O	redox protein regulator of disulfide bond formation
C1_01721	155864.EDL933_2160	1.2e-32	145.2	Escherichia	bdm	GO:0008150,GO:0010638,GO:0031344,GO:0031346,GO:0033043,GO:0044087,GO:0044089,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0060491,GO:0065007,GO:1902115,GO:1902117,GO:1902208,GO:1902210											Bacteria	1N3CC@1224,1SBZ1@1236,2CPZC@1,32SK6@2,3XR4N@561	NA|NA|NA	S	positive regulation of bacterial-type flagellum assembly
C1_01722	155864.EDL933_2161	6.3e-16	89.0	Gammaproteobacteria	sra	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904		ko:K02972					ko00000,ko03009				Bacteria	1NIKN@1224,1SHIP@1236,2EN1Q@1,33FPW@2	NA|NA|NA	J	Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein
C1_01723	198214.SF1746	0.0	1132.9	Gammaproteobacteria	maeA	GO:0003674,GO:0003824,GO:0004470,GO:0004471,GO:0004473,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006094,GO:0006108,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016051,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0019318,GO:0019319,GO:0019752,GO:0032787,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0055114,GO:0071704,GO:1901576	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020		R00214	RC00105	ko00000,ko00001,ko01000			iSbBS512_1146.SbBS512_E1742	Bacteria	1MU0A@1224,1RQ11@1236,COG0281@1,COG0281@2	NA|NA|NA	C	Malic enzyme
C1_01724	155864.EDL933_2163	1e-187	662.5	Escherichia	adhP	GO:0003674,GO:0003824,GO:0004022,GO:0005488,GO:0006081,GO:0006117,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009636,GO:0009987,GO:0010033,GO:0016491,GO:0016614,GO:0016616,GO:0033554,GO:0042221,GO:0042493,GO:0043167,GO:0043169,GO:0044237,GO:0044248,GO:0045471,GO:0046185,GO:0046187,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0097305,GO:1901575,GO:1901700	1.1.1.1	ko:K00001,ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220		R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000			iECP_1309.ECP_1480	Bacteria	1MUTT@1224,1RPQC@1236,3XMXX@561,COG1064@1,COG1064@2	NA|NA|NA	C	acetaldehyde catabolic process
C1_01725	1440052.EAKF1_ch0024	6.7e-44	183.0	Escherichia	yddM			ko:K21498					ko00000,ko02048				Bacteria	1N2BD@1224,1SDXN@1236,3XPWQ@561,COG3093@1,COG3093@2	NA|NA|NA	K	sequence-specific DNA binding
C1_01726	155864.EDL933_2165	1.5e-118	432.2	Escherichia	fdnI	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009326,GO:0009987,GO:0015942,GO:0015944,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0020037,GO:0022900,GO:0031224,GO:0031226,GO:0032787,GO:0032991,GO:0036397,GO:0043436,GO:0044237,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0052738,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1902494		ko:K00127,ko:K08350	ko00630,ko00680,ko01100,ko01120,ko01200,ko02020,map00630,map00680,map01100,map01120,map01200,map02020		R00519	RC02796	ko00000,ko00001	5.A.3.2		iEC042_1314.EC042_1608,iECED1_1282.ECED1_1627,iECNA114_1301.ECNA114_3649,iECSF_1327.ECSF_1390,iECUMN_1333.ECUMN_1730,ic_1306.c1907	Bacteria	1MXFQ@1224,1RRKV@1236,3XN1G@561,COG2864@1,COG2864@2	NA|NA|NA	C	to use formate as major electron donor during anaerobic respiration, when nitrate is used as electron acceptor. Subunit gamma is the cytochrome b556 component of the formate dehydrogenase-N, and also contains a menaquinone reduction site that receives electrons from the beta subunit (FdnH), through its hemes. Formate
C1_01727	198214.SF1750	1e-175	622.5	Gammaproteobacteria	fdnH	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009326,GO:0009897,GO:0009986,GO:0009987,GO:0015942,GO:0015944,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0031224,GO:0031226,GO:0031233,GO:0032787,GO:0032991,GO:0036397,GO:0043436,GO:0044237,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0052738,GO:0055114,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:1902494		ko:K00124,ko:K08349	ko00630,ko00680,ko01100,ko01120,ko01200,ko02020,map00630,map00680,map01100,map01120,map01200,map02020		R00519	RC02796	ko00000,ko00001	5.A.3.2		iAF1260.b3893,iAPECO1_1312.APECO1_2572,iB21_1397.B21_03727,iBWG_1329.BWG_3563,iEC042_1314.EC042_4267,iEC55989_1330.EC55989_4370,iECABU_c1320.ECABU_c43980,iECBD_1354.ECBD_4132,iECB_1328.ECB_03778,iECDH10B_1368.ECDH10B_4083,iECDH1ME8569_1439.ECDH1ME8569_3764,iECD_1391.ECD_03778,iECED1_1282.ECED1_4596,iECIAI1_1343.ECIAI1_4097,iECIAI39_1322.ECIAI39_3106,iECO103_1326.ECO103_4634,iECO26_1355.ECO26_4693,iECOK1_1307.ECOK1_4361,iECP_1309.ECP_1476,iECP_1309.ECP_4105,iECS88_1305.ECS88_4341,iECSE_1348.ECSE_4179,iECUMN_1333.ECUMN_4423,iECW_1372.ECW_m4202,iEKO11_1354.EKO11_4464,iEcDH1_1363.EcDH1_4091,iEcE24377_1341.EcE24377A_4422,iEcHS_1320.EcHS_A4121,iEcSMS35_1347.EcSMS35_4279,iEcolC_1368.EcolC_4125,iJO1366.b3893,iJR904.b3893,iLF82_1304.LF82_0634,iNRG857_1313.NRG857_19435,iSBO_1134.SBO_3907,iSFV_1184.SFV_3602,iSF_1195.SF3969,iSSON_1240.SSON_4062,iS_1188.S3779,iUMN146_1321.UM146_19695,iUMNK88_1353.UMNK88_4726,iUTI89_1310.UTI89_C4480,iWFL_1372.ECW_m4202,iY75_1357.Y75_RS17605,ic_1306.c4843	Bacteria	1MU1B@1224,1RNFG@1236,COG0437@1,COG0437@2	NA|NA|NA	C	formate dehydrogenase
C1_01728	469008.B21_01444	0.0	1667.5	Escherichia	fdnG	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006082,GO:0006091,GO:0006464,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008430,GO:0009055,GO:0009061,GO:0009326,GO:0009987,GO:0015942,GO:0015944,GO:0015980,GO:0016043,GO:0016226,GO:0016491,GO:0016622,GO:0016903,GO:0016999,GO:0017144,GO:0018282,GO:0018289,GO:0018291,GO:0019538,GO:0019752,GO:0022607,GO:0022900,GO:0030151,GO:0030288,GO:0030313,GO:0031163,GO:0031975,GO:0032787,GO:0032991,GO:0036211,GO:0036397,GO:0042597,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044464,GO:0045333,GO:0046872,GO:0046914,GO:0047111,GO:0048037,GO:0051186,GO:0051536,GO:0051539,GO:0051540,GO:0052738,GO:0055114,GO:0071704,GO:0071840,GO:1901564,GO:1902494	1.17.1.9,1.17.5.3	ko:K00123,ko:K08348	ko00630,ko00680,ko01100,ko01120,ko01200,ko02020,map00630,map00680,map01100,map01120,map01200,map02020		R00519	RC02796	ko00000,ko00001,ko01000	5.A.3.2		iECW_1372.ECW_m4203,iECs_1301.ECs2078,iUMNK88_1353.UMNK88_1879,iWFL_1372.ECW_m4203,iZ_1308.Z2236	Bacteria	1MW3N@1224,1RN6N@1236,3XM6Z@561,COG0243@1,COG0243@2,COG3383@1,COG3383@2	NA|NA|NA	C	Formate dehydrogenase allows E.coli to use formate as major electron donor during anaerobic respiration, when nitrate is used as electron acceptor. The alpha subunit FdnG contains the formate oxidation site. Electrons are transferred from formate to menaquinone in the gamma subunit (FdnI), through the 4Fe-4S clusters in the beta subunit (FdnH). Formate dehydrogenase-N is part of a system that generates proton motive force, together with the dissimilatory nitrate reductase (Nar)
C1_01729	155864.EDL933_2167	1.9e-109	401.7	Escherichia	fdnG	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006082,GO:0006091,GO:0006464,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008430,GO:0009055,GO:0009061,GO:0009326,GO:0009987,GO:0015942,GO:0015944,GO:0015980,GO:0016043,GO:0016226,GO:0016491,GO:0016622,GO:0016903,GO:0016999,GO:0017144,GO:0018282,GO:0018289,GO:0018291,GO:0019538,GO:0019752,GO:0022607,GO:0022900,GO:0030151,GO:0030288,GO:0030313,GO:0031163,GO:0031975,GO:0032787,GO:0032991,GO:0036211,GO:0036397,GO:0042597,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044464,GO:0045333,GO:0046872,GO:0046914,GO:0047111,GO:0048037,GO:0051186,GO:0051536,GO:0051539,GO:0051540,GO:0052738,GO:0055114,GO:0071704,GO:0071840,GO:1901564,GO:1902494	1.17.1.9,1.17.5.3	ko:K00123,ko:K08348	ko00630,ko00680,ko01100,ko01120,ko01200,ko02020,map00630,map00680,map01100,map01120,map01200,map02020		R00519	RC02796	ko00000,ko00001,ko01000	5.A.3.2		iECW_1372.ECW_m4203,iECs_1301.ECs2078,iUMNK88_1353.UMNK88_1879,iWFL_1372.ECW_m4203,iZ_1308.Z2236	Bacteria	1MW3N@1224,1RN6N@1236,3XM6Z@561,COG0243@1,COG0243@2,COG3383@1,COG3383@2	NA|NA|NA	C	Formate dehydrogenase allows E.coli to use formate as major electron donor during anaerobic respiration, when nitrate is used as electron acceptor. The alpha subunit FdnG contains the formate oxidation site. Electrons are transferred from formate to menaquinone in the gamma subunit (FdnI), through the 4Fe-4S clusters in the beta subunit (FdnH). Formate dehydrogenase-N is part of a system that generates proton motive force, together with the dissimilatory nitrate reductase (Nar)
C1_01730	155864.EDL933_2168	1.3e-151	542.3	Escherichia	yddG	GO:0003333,GO:0003674,GO:0005215,GO:0005302,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015179,GO:0015192,GO:0015196,GO:0015238,GO:0015318,GO:0015711,GO:0015801,GO:0015807,GO:0015823,GO:0015827,GO:0015828,GO:0015849,GO:0015893,GO:0016020,GO:0022857,GO:0034220,GO:0042221,GO:0042493,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903825,GO:1905039										iBWG_1329.BWG_1294,iE2348C_1286.E2348C_1607,iECDH10B_1368.ECDH10B_1604,iECDH1ME8569_1439.ECDH1ME8569_1416,iECS88_1305.ECS88_1565,iEcDH1_1363.EcDH1_2175,iJO1366.b1473,iNRG857_1313.NRG857_07295,iSSON_1240.SSON_1651,iUMN146_1321.UM146_09675	Bacteria	1MVGC@1224,1RMXB@1236,3XPG3@561,COG0697@1,COG0697@2	NA|NA|NA	EG	L-tyrosine transmembrane transporter activity
C1_01731	316407.1742405	1.3e-47	195.3	Gammaproteobacteria	yddL			ko:K14062,ko:K16076					ko00000,ko02000	1.B.1.1,1.B.1.1.4,1.B.1.1.5			Bacteria	1MVRY@1224,1RNBS@1236,COG3203@1,COG3203@2	NA|NA|NA	M	Belongs to the Gram-negative porin family
C1_01732	481805.EcolC_2186	2.8e-206	724.5	Bacteria	yddK												Bacteria	COG4886@1,COG4886@2	NA|NA|NA	S	regulation of response to stimulus
C1_01733	481805.EcolC_2187	3.8e-257	893.6	Escherichia	narU	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K02575	ko00910,map00910	M00615			ko00000,ko00001,ko00002,ko02000	2.A.1.8		iEcolC_1368.EcolC_2187,iUTI89_1310.UTI89_C1420	Bacteria	1MU27@1224,1RMUK@1236,3XNUK@561,COG2223@1,COG2223@2	NA|NA|NA	P	Catalyzes nitrate uptake, nitrite uptake and nitrite export across the cytoplasmic membrane. May function as a nitrate H( ) and nitrite H( ) channel. Could confer a selective advantage during severe nutrient starvation or slow growth
C1_01734	316407.85674979	0.0	2607.4	Escherichia	narG	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006091,GO:0006807,GO:0008150,GO:0008152,GO:0008940,GO:0009055,GO:0009061,GO:0009325,GO:0009898,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016661,GO:0019645,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0031235,GO:0032991,GO:0042126,GO:0043436,GO:0043546,GO:0044237,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0044799,GO:0045333,GO:0048037,GO:0050662,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0097159,GO:0098552,GO:0098562,GO:0098796,GO:0098797,GO:0098803,GO:1901363,GO:1902494,GO:1990204,GO:2001057	1.7.5.1	ko:K00370,ko:K17050	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.1,5.A.3.8		iSBO_1134.SBO_1842,iUMN146_1321.UM146_09685	Bacteria	1MW9S@1224,1RQ27@1236,3XNWC@561,COG5013@1,COG5013@2	NA|NA|NA	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C1_01735	481805.EcolC_2189	0.0	1083.9	Escherichia	narH	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008940,GO:0009055,GO:0009061,GO:0009325,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016661,GO:0019645,GO:0022900,GO:0022904,GO:0032991,GO:0033554,GO:0044237,GO:0044464,GO:0045333,GO:0048037,GO:0050896,GO:0051536,GO:0051540,GO:0051716,GO:0055114,GO:0071944,GO:1902494	1.7.5.1	ko:K00371	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1		iAF987.Gmet_1021,iEcE24377_1341.EcE24377A_1376,iEcolC_1368.EcolC_2189	Bacteria	1MW9Q@1224,1RNMJ@1236,3XP9D@561,COG1140@1,COG1140@2	NA|NA|NA	C	This is a second nitrate reductase enzyme which can substitute for the NRA enzyme and allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The beta chain is an electron transfer unit containing four cysteine clusters involved in the formation of iron-sulfur centers. Electrons are transferred from the gamma chain to the molybdenum cofactor of the alpha subunit
C1_01736	316407.1742385	1.5e-126	458.8	Escherichia	narJ	GO:0001666,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009987,GO:0016043,GO:0016530,GO:0022607,GO:0034622,GO:0036293,GO:0042126,GO:0042128,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0050896,GO:0051131,GO:0065003,GO:0070482,GO:0071704,GO:0071840,GO:0071941,GO:0140104,GO:2001057	1.7.5.1	ko:K00370,ko:K00373,ko:K17052	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.1,5.A.3.8		iE2348C_1286.E2348C_1350,iECABU_c1320.ECABU_c15020,iECIAI1_1343.ECIAI1_1469,iECW_1372.ECW_m1594,iEKO11_1354.EKO11_2354,iLF82_1304.LF82_1462,iNRG857_1313.NRG857_06280,iSSON_1240.SSON_1659,iWFL_1372.ECW_m1594,iYO844.BSU37260,ic_1306.c1687	Bacteria	1MY4E@1224,1RZMN@1236,3XNWD@561,COG2180@1,COG2180@2	NA|NA|NA	C	nitrate reductase 2
C1_01737	155864.EDL933_2177	5.4e-124	450.3	Escherichia	narI	GO:0001666,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006950,GO:0008150,GO:0008152,GO:0008940,GO:0009055,GO:0009061,GO:0009628,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016661,GO:0019645,GO:0020037,GO:0022900,GO:0022904,GO:0036293,GO:0044237,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0050896,GO:0055114,GO:0070482,GO:0071944,GO:0097159,GO:1901363	1.7.5.1	ko:K00370,ko:K00374,ko:K02575	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00615,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.1.8,5.A.3.1		iEC042_1314.EC042_1594,iECABU_c1320.ECABU_c17020,iECUMN_1333.ECUMN_1718,iNJ661.Rv1164,iSF_1195.SF1230,ic_1306.c1897	Bacteria	1MXGZ@1224,1RPTD@1236,3XPBJ@561,COG2181@1,COG2181@2	NA|NA|NA	C	This is a second nitrate reductase enzyme which can substitute for the NRA enzyme and allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The gamma chain is a membrane-embedded heme-iron unit resembling cytochrome b, which transfers electrons from quinones to the beta subunit
C1_01738	316407.1742383	6.7e-167	593.2	Escherichia	yddE		5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835			ko00000,ko00001,ko00002,ko01000				Bacteria	1MUAS@1224,1S0T9@1236,3XQ51@561,COG0384@1,COG0384@2	NA|NA|NA	S	isomerase activity
C1_01739	469008.B21_01433	2.7e-165	587.8	Escherichia	nhoA	GO:0003674,GO:0003824,GO:0004060,GO:0005575,GO:0005623,GO:0005886,GO:0008080,GO:0008374,GO:0016020,GO:0016407,GO:0016410,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0044464,GO:0046990,GO:0071944	2.3.1.118,2.3.1.5	ko:K00622,ko:K00675	ko00232,ko00633,ko00983,ko01100,ko01110,ko01120,ko05204,map00232,map00633,map00983,map01100,map01110,map01120,map05204		R07940,R08036,R08248,R08250,R11902	RC00004,RC00416,RC00962,RC02961	ko00000,ko00001,ko01000			iECs_1301.ECs2066,iEcHS_1320.EcHS_A1547,iEcSMS35_1347.EcSMS35_1711,iZ_1308.Z2250	Bacteria	1RDF3@1224,1RQTF@1236,3XMHM@561,COG2162@1,COG2162@2	NA|NA|NA	Q	Catalyzes the acetyl-CoA-dependent N-acetylation of aromatic amines, and, probably, the O-acetylation of N- hydroxyarylamines. In vitro, catalyzes the N-acetylation of various arylamines such as aminobenzoic acid, aminophenol, aminotoluene, phenetidine, anisidine, aniline, isoniazid and 2- amino-fluorene. N-hydroxyarylamine O-acetyltransferase activity has not been assayed directly, however, NhoA activity is required for the mutagenicity of nitroaromatic compounds, suggesting that it also has O-acetyltransferase activity
C1_01740	469008.B21_01432	6.5e-107	393.3	Escherichia	yddH												Bacteria	1NB1B@1224,1RQU5@1236,3XNUH@561,COG1853@1,COG1853@2	NA|NA|NA	S	FMN binding
C1_01741	155864.EDL933_2183	3.4e-35	153.7	Escherichia	pptA		5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000				Bacteria	1NAGG@1224,1SDP6@1236,3XQ2H@561,COG1942@1,COG1942@2	NA|NA|NA	S	Belongs to the 4-oxalocrotonate tautomerase family. PptA subfamily
C1_01742	155864.EDL933_2185	3.5e-103	380.9	Gammaproteobacteria													Bacteria	1MXB5@1224,1RSAV@1236,COG5433@1,COG5433@2	NA|NA|NA	L	Transposase
C1_01743	155864.EDL933_2186	3.9e-26	123.2	Bacteria	ydcC												Bacteria	COG5433@1,COG5433@2	NA|NA|NA	L	transposase activity
C1_01744	155864.EDL933_2188	5.9e-22	110.5	Gammaproteobacteria													Bacteria	1P60A@1224,1SUK0@1236,2CJS2@1,2ZITP@2	NA|NA|NA		
C1_01745	155864.EDL933_2189	0.0	2441.4	Escherichia													Bacteria	1MVV1@1224,1SKYM@1236,3XQWR@561,COG3209@1,COG3209@2	NA|NA|NA	M	Rhs elements have a nonessential function. They may play an important role in the natural ecology of the cell
C1_01746	481805.EcolC_2202	0.0	1183.3	Escherichia	vgrG			ko:K11904	ko03070,map03070	M00334			ko00000,ko00001,ko00002,ko02044	3.A.23.1			Bacteria	1MU7Q@1224,1S0Z3@1236,3XRIC@561,COG3501@1,COG3501@2	NA|NA|NA	S	TIGRFAM type VI secretion system Vgr family protein
C1_01748	155864.EDL933_2193	6e-114	416.8	Escherichia	yncG		2.5.1.18	ko:K00799,ko:K11208,ko:K11209	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418		R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2			Bacteria	1RGW9@1224,1RPXA@1236,3XQZC@561,COG0625@1,COG0625@2	NA|NA|NA	O	disulfide oxidoreductase activity
C1_01749	469008.B21_01421	6.4e-279	966.1	Escherichia	ansP	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03293,ko:K11738					ko00000,ko02000	2.A.3.1,2.A.3.1.8		iAF1260.b1453,iBWG_1329.BWG_1279,iEC55989_1330.EC55989_1586,iECDH10B_1368.ECDH10B_1583,iECDH1ME8569_1439.ECDH1ME8569_1396,iECH74115_1262.ECH74115_2059,iECSP_1301.ECSP_1934,iEcDH1_1363.EcDH1_2193,iEcHS_1320.EcHS_A1540,iJO1366.b1453,iSbBS512_1146.SbBS512_E1725,iY75_1357.Y75_RS07645,iYL1228.KPN_01906	Bacteria	1MUPS@1224,1RPHF@1236,3XP2B@561,COG1113@1,COG1113@2	NA|NA|NA	E	amino acid transport
C1_01750	469008.B21_01420	3.5e-178	630.9	Escherichia	yncE	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0097159,GO:1901363											Bacteria	1PDS2@1224,1RPZQ@1236,3XMIW@561,COG3391@1,COG3391@2	NA|NA|NA	S	DNA binding
C1_01751	316407.85674971	0.0	1409.8	Escherichia	yncD			ko:K02014					ko00000,ko02000	1.B.14			Bacteria	1MUIH@1224,1RQYX@1236,3XP4X@561,COG4772@1,COG4772@2	NA|NA|NA	P	siderophore transport
C1_01752	316407.1742362	2.4e-116	424.9	Escherichia	mcbR	GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K13654					ko00000,ko03000				Bacteria	1MVXM@1224,1S2YM@1236,3XPWR@561,COG1802@1,COG1802@2	NA|NA|NA	K	Important for biofilm formation. Represses expression of McbA by binding to its promoter region, which prevents colanic acid overproduction and mucoidy
C1_01753	481805.EcolC_2210	1.5e-202	711.8	Escherichia	yncB			ko:K07119					ko00000				Bacteria	1MUC2@1224,1RNGM@1236,3XNV4@561,COG2130@1,COG2130@2	NA|NA|NA	S	Catalyzes the metal-independent reduction of curcumin to dihydrocurcumin (DHC) as an intermediate product, followed by further reduction to tetrahydrocurcumin (THC) as an end product. It also acts on 3-octene-2-one, 3-hepten-2-one, resveratrol, and trans-2-octenal
C1_01754	155864.EDL933_2201	6.2e-96	356.7	Escherichia	yncA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006473,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130		R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000				Bacteria	1RDNE@1224,1RR6A@1236,3XNM3@561,COG1247@1,COG1247@2	NA|NA|NA	M	Acyltransferase that appears to be required for E.coli optimal growth rate and yield via the formation of N-acetylated amino acids. Catalyzes the acylation of L-methionine using acetyl- CoA or propanoyl-CoA as acyl donors, and the acetylation of L- phenylglycine. Is also able to N-acylate other free L-amino acids and their derivatives using a CoA thioester as cosubstrate. Using acetyl-CoA as an acyl donor, substrate specificity is methionine sulfone methionine sulfoximine methionine sulfoxide methionine. Asparagine, lysine, glutamine, aspartate and glutamate are very poor substrates. Using methionine as a substrate, acyl donor preference is propanoyl-CoA acetyl- CoA butyryl-CoA (Ref.4). Likely plays a role in the resistance against the toxic effects of L-methionine sulfoximine (MSX), via its ability to catalyze its acetylation
C1_01755	316407.85674968	1.6e-71	275.4	Escherichia	ydcZ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K09936	ko02024,map02024				ko00000,ko00001,ko02000	2.A.7.21			Bacteria	1RACX@1224,1S218@1236,3XPJM@561,COG3238@1,COG3238@2	NA|NA|NA	S	Putative inner membrane exporter, YdcZ
C1_01756	155864.EDL933_2203	7.4e-33	146.0	Escherichia	ydcY	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Bacteria	1N4XF@1224,1S8R1@1236,2D0NU@1,32T8Y@2,3XQ20@561	NA|NA|NA	S	Protein of unknown function (DUF2526)
C1_01757	199310.c1870	6.7e-23	112.5	Escherichia	ydcX												Bacteria	1N8R7@1224,1SCPI@1236,2E4I9@1,32ZDC@2,3XQ4N@561	NA|NA|NA	S	Toxin GhoT_OrtT
C1_01758	198214.SF1773	1.4e-78	298.9	Gammaproteobacteria	vat		6.3.2.29,6.3.2.30	ko:K03802,ko:K18234					ko00000,ko01000,ko01504				Bacteria	1MUCJ@1224,1RPPT@1236,COG0110@1,COG0110@2	NA|NA|NA	S	COG0110 Acetyltransferase (isoleucine patch superfamily)
C1_01759	198214.SF1773	1.1e-54	219.2	Gammaproteobacteria	vat		6.3.2.29,6.3.2.30	ko:K03802,ko:K18234					ko00000,ko01000,ko01504				Bacteria	1MUCJ@1224,1RPPT@1236,COG0110@1,COG0110@2	NA|NA|NA	S	COG0110 Acetyltransferase (isoleucine patch superfamily)
C1_01760	469008.B21_01412	2.9e-273	947.2	Escherichia	prr	GO:0003674,GO:0003824,GO:0004029,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0019145,GO:0033737,GO:0034641,GO:0042402,GO:0042802,GO:0044106,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071704,GO:0097164,GO:1901564,GO:1901565,GO:1901575	1.2.1.19,1.2.1.3	ko:K00128,ko:K00137	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000			iAF1260.b1444,iBWG_1329.BWG_1269,iECDH10B_1368.ECDH10B_1574,iECDH1ME8569_1439.ECDH1ME8569_1387,iEcDH1_1363.EcDH1_2202,iJO1366.b1444,iY75_1357.Y75_RS07595	Bacteria	1MU1V@1224,1RMBQ@1236,3XN8Z@561,COG1012@1,COG1012@2	NA|NA|NA	C	Catalyzes the oxidation of 1-pyrroline, which is spontaneously formed from 4-aminobutanal, leading to 4- aminobutanoate (GABA)
C1_01761	155864.EDL933_2207	5.6e-141	506.9	Escherichia	ydcV	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0009290,GO:0009292,GO:0009294,GO:0009987,GO:0015931,GO:0016020,GO:0044464,GO:0044764,GO:0050657,GO:0051027,GO:0051179,GO:0051234,GO:0051704,GO:0071702,GO:0071705,GO:0071944,GO:0098657		ko:K02053,ko:K11070	ko02010,ko02024,map02010,map02024	M00193,M00299			ko00000,ko00001,ko00002,ko02000	3.A.1.11,3.A.1.11.1		iEC55989_1330.EC55989_1575,iECIAI1_1343.ECIAI1_1439,iECO111_1330.ECO111_1832,iECO26_1355.ECO26_2042,iECW_1372.ECW_m1571,iECs_1301.ECs2047,iEKO11_1354.EKO11_2376,iUMNK88_1353.UMNK88_1846,iWFL_1372.ECW_m1571,iZ_1308.Z2276,ic_1306.c1867	Bacteria	1N3TB@1224,1RP67@1236,3XMKH@561,COG1177@1,COG1177@2	NA|NA|NA	P	ABC transporter permease protein
C1_01762	469008.B21_01410	2.8e-171	607.8	Escherichia	ydcU	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02054,ko:K11071	ko02010,ko02024,map02010,map02024	M00193,M00299			ko00000,ko00001,ko00002,ko02000	3.A.1.11,3.A.1.11.1		iEcSMS35_1347.EcSMS35_1732	Bacteria	1NU6V@1224,1RZ7V@1236,3XN29@561,COG1176@1,COG1176@2	NA|NA|NA	P	ABC transporter permease
C1_01763	316407.1742349	3e-187	661.0	Escherichia	ydcT		3.6.3.31	ko:K02052,ko:K11072	ko02010,ko02024,map02010,map02024	M00193,M00299			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11,3.A.1.11.1			Bacteria	1MU3I@1224,1RNPX@1236,3XNK0@561,COG3842@1,COG3842@2	NA|NA|NA	P	Belongs to the ABC transporter superfamily
C1_01764	316407.85674965	4.7e-229	800.0	Escherichia	ydcS	GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0008152,GO:0009058,GO:0009290,GO:0009292,GO:0009294,GO:0009987,GO:0015931,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042618,GO:0042619,GO:0044464,GO:0044764,GO:0050657,GO:0051027,GO:0051179,GO:0051234,GO:0051704,GO:0071702,GO:0071704,GO:0071705,GO:0098657,GO:1901440,GO:1901441,GO:1901576		ko:K02055	ko02024,map02024	M00193			ko00000,ko00001,ko00002,ko02000	3.A.1.11		iECNA114_1301.ECNA114_1576,iECSF_1327.ECSF_1364,iEcHS_1320.EcHS_A1524	Bacteria	1NKD7@1224,1RQPF@1236,3XMXD@561,COG0687@1,COG0687@2	NA|NA|NA	P	ABC transporter
C1_01765	316407.1742348	6.9e-267	926.0	Escherichia	ydcR	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576	2.7.7.65	ko:K21023	ko02025,map02025				ko00000,ko00001,ko01000				Bacteria	1MV6F@1224,1RMQ0@1236,3XMGP@561,COG1167@1,COG1167@2	NA|NA|NA	K	Transcriptional regulator
C1_01766	469008.B21_01406	1.6e-73	282.0	Escherichia	hicB			ko:K18843					ko00000,ko02048				Bacteria	1RI8S@1224,1S7DJ@1236,3XPY0@561,COG1598@1,COG1598@2	NA|NA|NA	K	Antitoxin component of a type II toxin-antitoxin (TA) system. Functions as an mRNA interferase antitoxin
C1_01767	155864.EDL933_2213	7.8e-27	125.6	Escherichia	hicA	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016787,GO:0016788,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575		ko:K07339					ko00000,ko01000,ko02048				Bacteria	1NAEE@1224,1SCFQ@1236,3XRBG@561,COG1724@1,COG1724@2	NA|NA|NA	J	this blockage is overcome (after 90 minutes) by subsequent expression of antitoxin HicB. Overexpression causes cleavage of a number of mRNAs and tmRNA, in a translation-independent fashion, suggesting this is an mRNA interferase. mRNA interferases play a role in bacterial persistence to antibiotics
C1_01768	316407.85674962	1.6e-24	117.9	Escherichia	yncJ												Bacteria	1N3QK@1224,1SC16@1236,2DTBF@1,32UUW@2,3XQ27@561	NA|NA|NA	S	Protein of unknown function (DUF2554)
C1_01769	469008.B21_01403	0.0	1307.0	Escherichia	ydcP			ko:K08303	ko05120,map05120				ko00000,ko00001,ko01000,ko01002				Bacteria	1MUQG@1224,1RN7S@1236,3XN5V@561,COG0826@1,COG0826@2	NA|NA|NA	O	peptidase activity
C1_01770	316407.1742340	4.4e-97	360.5	Escherichia	ydcN	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043565,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141											Bacteria	1R4NU@1224,1RQG0@1236,3XPJ9@561,COG1396@1,COG1396@2	NA|NA|NA	K	Regulates the expression of 12-16 transcription units involved in various steps of sulfur utilization. Represses expression of pfkB, fliZ, cysE, ydcO and its own expression. Activates expression of ypfN. Acts by binding to SutR boxes
C1_01771	316407.85674961	8.2e-205	719.5	Escherichia	ydcO	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K05782					ko00000,ko02000	2.A.46.1			Bacteria	1MUS1@1224,1RMD5@1236,3XNV8@561,COG3135@1,COG3135@2	NA|NA|NA	Q	benzoate transport
C1_01772	316407.85674960	1e-212	745.7	Escherichia	Z012_11195			ko:K07496					ko00000				Bacteria	1MUU0@1224,1RS1J@1236,3XPN5@561,COG0675@1,COG0675@2	NA|NA|NA	L	Transposase
C1_01773	155864.EDL933_2219	6.4e-122	443.4	Escherichia	ydcL												Bacteria	1PZJF@1224,1S1AH@1236,28IHQ@1,2Z8IX@2,3XM9V@561	NA|NA|NA	M	Protein of unknown function (DUF3313)
C1_01774	316407.1742337	5.6e-109	400.2	Escherichia	tehB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0010035,GO:0016740,GO:0016741,GO:0032259,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0046690,GO:0050896	2.1.1.265	ko:K16868					ko00000,ko01000				Bacteria	1MX7K@1224,1RSD0@1236,3XNT6@561,COG0500@1,COG0500@2	NA|NA|NA	Q	Tellurite resistance
C1_01775	198214.SF1781	1.7e-182	645.2	Gammaproteobacteria	tehA	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0010035,GO:0015075,GO:0015562,GO:0016020,GO:0022857,GO:0034220,GO:0042221,GO:0042802,GO:0044464,GO:0046583,GO:0046690,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098655		ko:K03304					ko00000,ko02000	2.A.16.1			Bacteria	1MVPG@1224,1RPVM@1236,COG1275@1,COG1275@2	NA|NA|NA	P	PFAM C4-dicarboxylate transporter malic acid transport protein
C1_01776	481805.EcolC_2232	3e-168	597.8	Escherichia	ydcK			ko:K02617,ko:K08279					ko00000				Bacteria	1QWBX@1224,1T2TA@1236,3XM3M@561,COG0663@1,COG0663@2	NA|NA|NA	S	transferase activity, transferring acyl groups
C1_01777	316407.1742324	3.7e-96	357.5	Escherichia	rimL	GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008999,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0017198,GO:0018193,GO:0018209,GO:0019538,GO:0030920,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564,GO:1990189		ko:K03817					ko00000,ko01000,ko03009				Bacteria	1RGKF@1224,1S28M@1236,3XMIJ@561,COG1670@1,COG1670@2	NA|NA|NA	J	N-terminal peptidyl-serine acetylation
C1_01778	316407.85674957	2.1e-32	144.4	Escherichia	ydcH			ko:K09794					ko00000				Bacteria	1N760@1224,1SD65@1236,3XQ4I@561,COG2841@1,COG2841@2	NA|NA|NA	S	Protein of unknown function (DUF465)
C1_01779	155864.EDL933_2226	0.0	1129.4	Escherichia	mdoD	GO:0000271,GO:0005575,GO:0005623,GO:0005975,GO:0005976,GO:0006073,GO:0006109,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009311,GO:0009312,GO:0009889,GO:0009987,GO:0010556,GO:0010675,GO:0010962,GO:0016051,GO:0019222,GO:0030288,GO:0030313,GO:0031323,GO:0031326,GO:0031975,GO:0032881,GO:0032885,GO:0032950,GO:0032951,GO:0033692,GO:0034637,GO:0034645,GO:0042597,GO:0043170,GO:0043255,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0050789,GO:0050794,GO:0051273,GO:0051274,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:1901576,GO:2000112		ko:K03670					ko00000				Bacteria	1MUNX@1224,1RMEB@1236,3XNJA@561,COG3131@1,COG3131@2	NA|NA|NA	P	Probably involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans (OPGs)
C1_01780	316407.85674956	6.2e-257	892.9	Escherichia	ydcJ												Bacteria	1P16G@1224,1RR9P@1236,3XNHY@561,COG5383@1,COG5383@2	NA|NA|NA	S	DUF1338
C1_01781	481805.EcolC_2237	2.6e-169	601.3	Escherichia	pcaQ	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K02623					ko00000,ko03000				Bacteria	1MX53@1224,1RS04@1236,3XPDJ@561,COG0583@1,COG0583@2	NA|NA|NA	K	transcriptional regulator
C1_01782	316407.1742320	2.6e-225	788.1	Escherichia	trg	GO:0001101,GO:0001932,GO:0003674,GO:0004888,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006928,GO:0006935,GO:0007154,GO:0007165,GO:0007172,GO:0008104,GO:0008150,GO:0009593,GO:0009605,GO:0009719,GO:0009893,GO:0009966,GO:0009987,GO:0010033,GO:0010243,GO:0010604,GO:0010646,GO:0016020,GO:0016021,GO:0016043,GO:0019220,GO:0019222,GO:0019899,GO:0019900,GO:0019901,GO:0022607,GO:0023051,GO:0023052,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031399,GO:0031401,GO:0032101,GO:0032110,GO:0032268,GO:0032270,GO:0032879,GO:0032991,GO:0033036,GO:0034613,GO:0034622,GO:0038023,GO:0040011,GO:0040012,GO:0042221,GO:0042325,GO:0042330,GO:0042802,GO:0042803,GO:0043113,GO:0043200,GO:0043424,GO:0043549,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045859,GO:0046983,GO:0048518,GO:0048522,GO:0048583,GO:0048870,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0050920,GO:0051171,GO:0051173,GO:0051174,GO:0051179,GO:0051246,GO:0051247,GO:0051259,GO:0051260,GO:0051270,GO:0051338,GO:0051606,GO:0051641,GO:0051668,GO:0051674,GO:0051716,GO:0060089,GO:0060255,GO:0065003,GO:0065007,GO:0065009,GO:0070727,GO:0070887,GO:0071229,GO:0071230,GO:0071310,GO:0071417,GO:0071495,GO:0071840,GO:0071944,GO:0072657,GO:0080090,GO:0098561,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1901873,GO:1901875,GO:1902021,GO:2000145		ko:K03406,ko:K05874,ko:K05875,ko:K05876,ko:K05877	ko02020,ko02030,map02020,map02030				ko00000,ko00001,ko02035				Bacteria	1MU9B@1224,1RMH0@1236,3XMAQ@561,COG0840@1,COG0840@2	NA|NA|NA	NT	Mediates taxis to the sugars ribose and galactose via an interaction with the periplasmic ribose- or galactose-binding proteins
C1_01784	198214.SF1793	2.7e-24	117.1	Gammaproteobacteria	ydcA			ko:K03646					ko00000,ko02000	2.C.1.2			Bacteria	1NKD8@1224,1SGNH@1236,2DSX4@1,33HSK@2	NA|NA|NA		
C1_01785	155864.EDL933_2231	4.4e-97	360.5	Escherichia	cybB	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0020037,GO:0044464,GO:0046906,GO:0048037,GO:0071944,GO:0097159,GO:1901363		ko:K12262					ko00000				Bacteria	1MWQJ@1224,1S4DB@1236,3XMPH@561,COG3038@1,COG3038@2	NA|NA|NA	C	Cytochrome b(561)
C1_01786	469008.B21_01383	1.2e-185	655.6	Escherichia	gap	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009986,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0019362,GO:0019637,GO:0019674,GO:0022610,GO:0034641,GO:0036094,GO:0043891,GO:0044237,GO:0044238,GO:0044281,GO:0044403,GO:0044406,GO:0044419,GO:0044424,GO:0044464,GO:0044650,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051287,GO:0051704,GO:0055086,GO:0055114,GO:0071704,GO:0072524,GO:0097159,GO:0140030,GO:0140032,GO:1901265,GO:1901360,GO:1901363,GO:1901564	1.2.1.12,1.2.1.72	ko:K00134,ko:K03472	ko00010,ko00710,ko00750,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map00750,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00124,M00165,M00166,M00308,M00552	R01061,R01825	RC00149,RC00242	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147			iAPECO1_1312.APECO1_847,iJR904.b1416,iJR904.b1417,iUTI89_1310.UTI89_C1975,ic_1306.c2184	Bacteria	1MU93@1224,1RMBM@1236,3XQM0@561,COG0057@1,COG0057@2	NA|NA|NA	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
C1_01787	155864.EDL933_2233	6.2e-271	939.5	Escherichia	aldA	GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0004029,GO:0004777,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006004,GO:0006082,GO:0006105,GO:0006520,GO:0006536,GO:0006538,GO:0006540,GO:0006807,GO:0008150,GO:0008152,GO:0008911,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009448,GO:0009450,GO:0009987,GO:0016043,GO:0016052,GO:0016054,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0019299,GO:0019301,GO:0019317,GO:0019318,GO:0019320,GO:0019752,GO:0022607,GO:0032787,GO:0036094,GO:0042133,GO:0042135,GO:0042354,GO:0042355,GO:0042802,GO:0043436,GO:0043648,GO:0043649,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046395,GO:0048037,GO:0050569,GO:0050662,GO:0051259,GO:0051260,GO:0051262,GO:0051287,GO:0051289,GO:0055114,GO:0065003,GO:0065007,GO:0065008,GO:0071704,GO:0071840,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.2.1.21,1.2.1.22	ko:K07248	ko00620,ko00630,ko01120,map00620,map00630,map01120		R00203,R01333,R01446	RC00080,RC00104,RC00242	ko00000,ko00001,ko01000			iAF1260.b1415,iBWG_1329.BWG_1242,iECDH10B_1368.ECDH10B_1541,iECDH1ME8569_1439.ECDH1ME8569_1358,iEcDH1_1363.EcDH1_2230,iJO1366.b1415,iJR904.b1415,iY75_1357.Y75_RS07435	Bacteria	1MU1V@1224,1RMBQ@1236,3XMD7@561,COG1012@1,COG1012@2	NA|NA|NA	C	dehydrogenase
C1_01788	316407.1742305	5.9e-154	550.1	Escherichia	ydcF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016021,GO:0031224,GO:0044425,GO:0044464,GO:0071944											Bacteria	1N4TG@1224,1RSJ5@1236,3XP6S@561,COG1434@1,COG1434@2	NA|NA|NA	S	DUF218 domain
C1_01789	155864.EDL933_2238	0.0	2573.1	Escherichia	hrpA	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0006139,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360	3.6.4.13	ko:K03578					ko00000,ko01000				Bacteria	1MUEQ@1224,1RMU1@1236,3XN59@561,COG1643@1,COG1643@2	NA|NA|NA	L	helicase HrpA
C1_01790	316407.1742298	6.5e-105	386.7	Escherichia	azoR	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0010181,GO:0016491,GO:0016651,GO:0016655,GO:0016661,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0046857,GO:0048037,GO:0050446,GO:0050662,GO:0050896,GO:0055114,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K01118					ko00000,ko01000				Bacteria	1P59R@1224,1S337@1236,3XN1B@561,COG1182@1,COG1182@2	NA|NA|NA	I	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C1_01791	316407.85674951	2.7e-137	494.6	Escherichia	ynbD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.1.3.16	ko:K01090					ko00000,ko01000				Bacteria	1QSUD@1224,1RQAC@1236,3XQE9@561,COG0671@1,COG0671@2,COG2453@1,COG2453@2	NA|NA|NA	IT	protein tyrosine phosphatase activity
C1_01792	316407.85674949	7e-72	276.6	Escherichia	cdsA	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009273,GO:0009987,GO:0016020,GO:0042546,GO:0044085,GO:0044464,GO:0071554,GO:0071840,GO:0071944	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000				Bacteria	1MX58@1224,1RRAG@1236,3XQ6J@561,COG4589@1,COG4589@2	NA|NA|NA	S	peptidoglycan-based cell wall biogenesis
C1_01793	362663.ECP_1413	6.7e-102	376.7	Escherichia	ynbA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100		R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000				Bacteria	1RE0I@1224,1S2UQ@1236,3XR1R@561,COG0558@1,COG0558@2	NA|NA|NA	I	phosphotransferase activity, for other substituted phosphate groups
C1_01794	481805.EcolC_2251	0.0	1466.8	Escherichia	ydbD												Bacteria	1NS8J@1224,1SMS5@1236,2EWBD@1,33PQ4@2,3XQG9@561	NA|NA|NA	S	Protein of unknown function (DUF2773)
C1_01795	316407.1742295	3.6e-157	560.8	Escherichia	ydbC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	1.1.1.65	ko:K05275	ko00750,ko01100,ko01120,map00750,map01100,map01120		R01708	RC00116	ko00000,ko00001,ko01000				Bacteria	1MWGZ@1224,1RRHM@1236,3XN0D@561,COG0667@1,COG0667@2	NA|NA|NA	C	Catalyzes the NAD(P)H-dependent reduction of pyridoxal to pyridoxine in vitro. Is not able to reduce 4-pyridoxate, and to oxidize pyridoxine or pyridoxamine. Has Kemp eliminase activity towards the non-physiological substrate 5- nitrobenzisoxazole, producing 4-nitro-2-cyanophenol
C1_01796	481805.EcolC_2255	1.3e-89	335.9	Gammaproteobacteria	paaY	GO:0003674,GO:0003824,GO:0016289,GO:0016787,GO:0016788,GO:0016790		ko:K02617,ko:K08279					ko00000				Bacteria	1MVUI@1224,1RYPQ@1236,COG0663@1,COG0663@2	NA|NA|NA	S	Phenylacetic acid degradation protein PaaY
C1_01797	316407.85674946	1.5e-177	628.6	Gammaproteobacteria	paaX	GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0006082,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006805,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010124,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0010817,GO:0016054,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019439,GO:0019748,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0032774,GO:0032787,GO:0034641,GO:0034645,GO:0034654,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043170,GO:0043254,GO:0043436,GO:0043565,GO:0044087,GO:0044212,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044282,GO:0045892,GO:0045934,GO:0046395,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0098754,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901575,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141		ko:K02616					ko00000,ko03000				Bacteria	1R4IF@1224,1RR7B@1236,COG3327@1,COG3327@2	NA|NA|NA	K	phenylacetic acid degradation operon negative regulatory protein
C1_01798	316407.85674945	1.5e-255	888.3	Gammaproteobacteria	paaK	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006082,GO:0006725,GO:0006805,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016054,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0017076,GO:0019439,GO:0019748,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0047475,GO:0050896,GO:0051716,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0097159,GO:0097367,GO:0098754,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111		R02539	RC00004,RC00014	ko00000,ko00001,ko01000			iECIAI1_1343.ECIAI1_1398,iECO111_1330.ECO111_1792,iECO26_1355.ECO26_2002,iECSE_1348.ECSE_1483,iECW_1372.ECW_m1532,iEKO11_1354.EKO11_2415,iEcE24377_1341.EcE24377A_1584,iWFL_1372.ECW_m1532	Bacteria	1MV1W@1224,1RQ3D@1236,COG1541@1,COG1541@2	NA|NA|NA	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
C1_01799	481805.EcolC_2258	1.2e-219	768.8	Escherichia	paaJ	GO:0003674,GO:0003824,GO:0006082,GO:0006725,GO:0006805,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016054,GO:0016740,GO:0016746,GO:0016747,GO:0019439,GO:0019748,GO:0019752,GO:0032787,GO:0033554,GO:0033812,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0050896,GO:0051716,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0098754,GO:1901360,GO:1901361,GO:1901575	2.3.1.16,2.3.1.174,2.3.1.223,2.3.1.9	ko:K00626,ko:K00632,ko:K02615	ko00071,ko00072,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00360,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095,R09839	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955,RC03003	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	1MU5G@1224,1RM93@1236,3XM40@561,COG0183@1,COG0183@2	NA|NA|NA	I	Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed
C1_01800	316407.85674944	1e-72	279.3	Gammaproteobacteria	paaI	GO:0003674,GO:0003824,GO:0016289,GO:0016787,GO:0016788,GO:0016790		ko:K02614	ko00360,map00360		R09840	RC00004,RC00014	ko00000,ko00001,ko01000			iBWG_1329.BWG_1225,iEC55989_1330.EC55989_1532,iECDH10B_1368.ECDH10B_1521,iECDH1ME8569_1439.EcDH1_2249,iECIAI1_1343.ECIAI1_1396,iECO103_1326.ECO103_1533,iECO111_1330.ECO111_1790,iECO26_1355.ECO26_2000,iECSE_1348.ECSE_1481,iEKO11_1354.EKO11_2417,iETEC_1333.ETEC_1471,iEcDH1_1363.EcDH1_2249,iEcE24377_1341.EcE24377A_1581,iEcHS_1320.EcHS_A1483,iEcolC_1368.EcolC_2259,iUMNK88_1353.UMNK88_1803,iY75_1357.Y75_RS07340	Bacteria	1RH35@1224,1S4EZ@1236,COG2050@1,COG2050@2	NA|NA|NA	Q	phenylacetic acid degradation protein
C1_01801	316407.85674943	2.7e-255	887.5	Escherichia	paaH	GO:0003674,GO:0003824,GO:0003857,GO:0004165,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0006725,GO:0006805,GO:0008150,GO:0008152,GO:0008691,GO:0008692,GO:0009056,GO:0009062,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016042,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016856,GO:0016860,GO:0016863,GO:0019395,GO:0019439,GO:0019748,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0098754,GO:1901360,GO:1901361,GO:1901575	1.1.1.157,1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8	ko:K00074,ko:K01782,ko:K01825	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R01976,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R04756,R05066,R05305,R05576,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01078,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000			iECO103_1326.ECO103_1532,iETEC_1333.ETEC_2476,iLF82_1304.LF82_0614,iNRG857_1313.NRG857_19200	Bacteria	1MU9P@1224,1RPVB@1236,3XRJK@561,COG1250@1,COG1250@2	NA|NA|NA	I	3-hydroxyacyl-CoA dehydrogenase
C1_01802	316407.1742270	3.2e-144	517.7	Gammaproteobacteria	paaG	GO:0003674,GO:0003824,GO:0004300,GO:0005488,GO:0005515,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0006725,GO:0006805,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0019395,GO:0019439,GO:0019748,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0098754,GO:1901360,GO:1901361,GO:1901575	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120		R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000			iECO103_1326.ECO103_1531,iJN746.PP_3283,iYL1228.KPN_01475	Bacteria	1MVQN@1224,1RPE2@1236,COG1024@1,COG1024@2	NA|NA|NA	I	Enoyl-CoA hydratase
C1_01803	316407.85674942	2.8e-129	468.0	Gammaproteobacteria	paaF	GO:0003674,GO:0003824,GO:0004300,GO:0005488,GO:0005515,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0006725,GO:0006805,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019439,GO:0019748,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0098754,GO:1901360,GO:1901361,GO:1901575	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000				Bacteria	1MWZC@1224,1RPSX@1236,COG1024@1,COG1024@2	NA|NA|NA	I	Belongs to the enoyl-CoA hydratase isomerase family
C1_01804	316407.85674941	1e-198	699.1	Gammaproteobacteria	paaE	GO:0000166,GO:0003674,GO:0005488,GO:0006082,GO:0006725,GO:0006805,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016054,GO:0019439,GO:0019748,GO:0019752,GO:0032787,GO:0036094,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051536,GO:0051537,GO:0051540,GO:0051716,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0097159,GO:0098754,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575		ko:K02613	ko00360,ko01120,map00360,map01120		R09838	RC02690	ko00000,ko00001			iEcHS_1320.EcHS_A1479	Bacteria	1MY2Q@1224,1RQZ8@1236,COG1018@1,COG1018@2	NA|NA|NA	C	COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1
C1_01805	481805.EcolC_2264	2.5e-94	351.3	Gammaproteobacteria	paaD	GO:0006082,GO:0006725,GO:0006805,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016054,GO:0019439,GO:0019748,GO:0019752,GO:0032787,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0050896,GO:0051716,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0098754,GO:1901360,GO:1901361,GO:1901575		ko:K02612	ko00360,ko01120,map00360,map01120		R09838	RC02690	ko00000,ko00001			iECSE_1348.ECSE_1476	Bacteria	1RF3S@1224,1S4FY@1236,COG2151@1,COG2151@2	NA|NA|NA	L	phenylacetate-CoA oxygenase, PaaJ subunit
C1_01806	316407.85674939	1e-139	502.7	Gammaproteobacteria	paaC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006725,GO:0006805,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016054,GO:0019439,GO:0019748,GO:0019752,GO:0032787,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0050896,GO:0051716,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0098754,GO:1901360,GO:1901361,GO:1901575	1.14.13.149	ko:K02611	ko00360,ko01120,map00360,map01120		R09838	RC02690	ko00000,ko00001,ko01000			iEC55989_1330.EC55989_1526,iECO111_1330.ECO111_1784,iECSE_1348.ECSE_1475,iECW_1372.ECW_m1524,iEKO11_1354.EKO11_2423,iWFL_1372.ECW_m1524	Bacteria	1MVYQ@1224,1RRSG@1236,COG3396@1,COG3396@2	NA|NA|NA	S	Phenylacetate-CoA oxygenase, PaaI subunit
C1_01807	316407.85674938	3.1e-49	200.7	Gammaproteobacteria	paaB	GO:0006082,GO:0006725,GO:0006805,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016054,GO:0019439,GO:0019748,GO:0019752,GO:0032787,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0050896,GO:0051716,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0098754,GO:1901360,GO:1901361,GO:1901575		ko:K02610	ko00360,ko01120,map00360,map01120		R09838	RC02690	ko00000,ko00001			iEcHS_1320.EcHS_A1476,iEcolC_1368.EcolC_2266	Bacteria	1RHM5@1224,1S7F4@1236,COG3460@1,COG3460@2	NA|NA|NA	Q	Phenylacetate-CoA oxygenase
C1_01808	481805.EcolC_2267	5.5e-180	636.7	Gammaproteobacteria	paaA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006725,GO:0006805,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016054,GO:0019439,GO:0019748,GO:0019752,GO:0032787,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0050896,GO:0051716,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0098754,GO:1901360,GO:1901361,GO:1901575	1.14.13.149	ko:K02609	ko00360,ko01120,map00360,map01120		R09838	RC02690	ko00000,ko00001,ko01000			iEC55989_1330.EC55989_1524,iECO111_1330.ECO111_1782,iECO26_1355.ECO26_1992,iEcE24377_1341.EcE24377A_1573	Bacteria	1MVQ7@1224,1RNRN@1236,COG3396@1,COG3396@2	NA|NA|NA	S	Phenylacetate-CoA oxygenase
C1_01809	316407.1742267	0.0	1338.2	Gammaproteobacteria	paaN	GO:0003674,GO:0003824,GO:0004300,GO:0006082,GO:0006725,GO:0006805,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016054,GO:0016491,GO:0016725,GO:0016726,GO:0016787,GO:0016801,GO:0016803,GO:0016822,GO:0016823,GO:0016829,GO:0016835,GO:0016836,GO:0019439,GO:0019748,GO:0019752,GO:0032787,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0098754,GO:1901360,GO:1901361,GO:1901575	1.2.1.91,3.3.2.12	ko:K02618	ko00360,ko01120,map00360,map01120		R09820,R09836	RC00080,RC02667	ko00000,ko00001,ko01000			iEC55989_1330.EC55989_1523,iECO111_1330.ECO111_1781,iECO26_1355.ECO26_1991	Bacteria	1MWD4@1224,1RVX0@1236,COG1012@1,COG1012@2,COG2030@1,COG2030@2	NA|NA|NA	CI	Aldehyde dehydrogenase
C1_01810	316407.1742266	0.0	1549.3	Gammaproteobacteria	tynA	GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005509,GO:0005575,GO:0005623,GO:0006576,GO:0006807,GO:0008131,GO:0008150,GO:0008152,GO:0009056,GO:0009308,GO:0009310,GO:0009987,GO:0016491,GO:0016638,GO:0016641,GO:0019607,GO:0034641,GO:0042402,GO:0042443,GO:0042597,GO:0043167,GO:0043169,GO:0044106,GO:0044237,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0048038,GO:0055114,GO:0071704,GO:0097164,GO:1901160,GO:1901161,GO:1901564,GO:1901565,GO:1901575	1.4.3.21	ko:K00276	ko00260,ko00350,ko00360,ko00410,ko00950,ko00960,ko01100,ko01110,map00260,map00350,map00360,map00410,map00950,map00960,map01100,map01110		R02382,R02529,R02613,R03139,R04027,R04300,R06154,R06740	RC00062,RC00189,RC00676,RC01052	ko00000,ko00001,ko01000			iETEC_1333.ETEC_1461	Bacteria	1MW7W@1224,1RNPU@1236,COG3733@1,COG3733@2	NA|NA|NA	Q	amine oxidase
C1_01811	316407.85674936	2.3e-89	334.7	Gammaproteobacteria	feaB	GO:0003674,GO:0003824,GO:0004029,GO:0006139,GO:0006576,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006805,GO:0006807,GO:0008150,GO:0008152,GO:0008957,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009308,GO:0009310,GO:0009410,GO:0009435,GO:0009987,GO:0016043,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0018958,GO:0018960,GO:0019336,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019607,GO:0019637,GO:0019674,GO:0022607,GO:0034641,GO:0034654,GO:0042178,GO:0042221,GO:0042402,GO:0042443,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044271,GO:0044281,GO:0046196,GO:0046483,GO:0046496,GO:0047106,GO:0050896,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051716,GO:0055086,GO:0055114,GO:0065003,GO:0070887,GO:0071466,GO:0071704,GO:0071840,GO:0072524,GO:0072525,GO:0090407,GO:0097164,GO:1901160,GO:1901161,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	1.2.1.39	ko:K00146	ko00360,ko00643,ko01100,ko01120,map00360,map00643,map01100,map01120		R02536	RC00080	ko00000,ko00001,ko01000			iYL1228.KPN_01455	Bacteria	1MU1V@1224,1RMBQ@1236,COG1012@1,COG1012@2	NA|NA|NA	C	belongs to the aldehyde dehydrogenase family
C1_01812	316407.85674936	4.3e-183	647.1	Gammaproteobacteria	feaB	GO:0003674,GO:0003824,GO:0004029,GO:0006139,GO:0006576,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006805,GO:0006807,GO:0008150,GO:0008152,GO:0008957,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009308,GO:0009310,GO:0009410,GO:0009435,GO:0009987,GO:0016043,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0018958,GO:0018960,GO:0019336,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019607,GO:0019637,GO:0019674,GO:0022607,GO:0034641,GO:0034654,GO:0042178,GO:0042221,GO:0042402,GO:0042443,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044271,GO:0044281,GO:0046196,GO:0046483,GO:0046496,GO:0047106,GO:0050896,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051716,GO:0055086,GO:0055114,GO:0065003,GO:0070887,GO:0071466,GO:0071704,GO:0071840,GO:0072524,GO:0072525,GO:0090407,GO:0097164,GO:1901160,GO:1901161,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	1.2.1.39	ko:K00146	ko00360,ko00643,ko01100,ko01120,map00360,map00643,map01100,map01120		R02536	RC00080	ko00000,ko00001,ko01000			iYL1228.KPN_01455	Bacteria	1MU1V@1224,1RMBQ@1236,COG1012@1,COG1012@2	NA|NA|NA	C	belongs to the aldehyde dehydrogenase family
C1_01813	316407.85674935	3.4e-166	590.9	Gammaproteobacteria	feaR	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006089,GO:0006355,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009438,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019172,GO:0019219,GO:0019222,GO:0019243,GO:0019249,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0043565,GO:0044212,GO:0044237,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0045893,GO:0045935,GO:0046185,GO:0046394,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051596,GO:0060255,GO:0061727,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1901575,GO:1901576,GO:1901615,GO:1901617,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141		ko:K14063					ko00000,ko03000				Bacteria	1QUXX@1224,1RSPT@1236,COG2207@1,COG2207@2	NA|NA|NA	K	transcriptional regulator
C1_01814	316407.85674934	1e-51	209.1	Escherichia	ydbL			ko:K09978					ko00000				Bacteria	1N6R1@1224,1SC8V@1236,3XQ16@561,COG3784@1,COG3784@2	NA|NA|NA	S	Protein of unknown function (DUF1318)
C1_01815	198214.SF1816	6.5e-24	115.9	Gammaproteobacteria	ynbE												Bacteria	1N8D8@1224,1SCAF@1236,2E371@1,32Y6T@2	NA|NA|NA	S	(Lipo)protein
C1_01816	481805.EcolC_2274	0.0	1773.8	Escherichia	ydbH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K07114					ko00000,ko02000	1.A.13.2.2,1.A.13.2.3			Bacteria	1MUT7@1224,1RQ5W@1236,3XMNC@561,COG2911@1,COG2911@2	NA|NA|NA	S	Dicarboxylate transport
C1_01817	155864.EDL933_2251	5.1e-184	650.2	Escherichia	ldhA	GO:0000166,GO:0003674,GO:0003824,GO:0004457,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006067,GO:0006082,GO:0006083,GO:0006089,GO:0006090,GO:0006091,GO:0006103,GO:0006105,GO:0006113,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008720,GO:0009117,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009179,GO:0009185,GO:0009199,GO:0009205,GO:0009259,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0015942,GO:0015980,GO:0016491,GO:0016614,GO:0016616,GO:0016999,GO:0017144,GO:0019318,GO:0019362,GO:0019637,GO:0019660,GO:0019664,GO:0019666,GO:0019693,GO:0019752,GO:0032787,GO:0034308,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0050896,GO:0051186,GO:0051287,GO:0055086,GO:0055114,GO:0070404,GO:0071704,GO:0072521,GO:0072524,GO:0097159,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901615	1.1.1.28	ko:K03778	ko00620,ko01120,map00620,map01120		R00704	RC00044	ko00000,ko00001,ko01000			iPC815.YPO2329,iSFV_1184.SFV_1805,iSF_1195.SF1814,iSFxv_1172.SFxv_2031,iS_1188.S1459	Bacteria	1MVSS@1224,1RMWR@1236,3XMY4@561,COG1052@1,COG1052@2	NA|NA|NA	CH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C1_01818	199310.c1826	2.3e-69	268.1	Escherichia	hslJ	GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0050896		ko:K03668					ko00000				Bacteria	1RFSD@1224,1S6MZ@1236,3XPKD@561,COG3187@1,COG3187@2	NA|NA|NA	O	Heat shock protein HslJ
C1_01819	316407.85674932	3.5e-39	167.2	Escherichia	ydbJ			ko:K09712,ko:K14475	ko05143,map05143				ko00000,ko00001				Bacteria	1RIV0@1224,1S71D@1236,3XPUC@561,COG3042@1,COG3042@2	NA|NA|NA	S	Domain of unknown function (DUF333)
C1_01820	316407.1742250	0.0	2341.2	Escherichia	nifJ	GO:0003674,GO:0003824,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016491,GO:0016625,GO:0016903,GO:0043873,GO:0050896,GO:0055114	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000			iJN678.nifJ,iLF82_1304.LF82_2789,iNRG857_1313.NRG857_06920	Bacteria	1MVM0@1224,1RNNX@1236,3XMK9@561,COG0674@1,COG0674@2,COG1013@1,COG1013@2,COG1014@1,COG1014@2,COG1143@1,COG1143@2	NA|NA|NA	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C1_01821	469008.B21_01360	2.5e-219	767.7	Escherichia	ompN	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0008643,GO:0009279,GO:0015267,GO:0015288,GO:0016020,GO:0019867,GO:0022803,GO:0022829,GO:0022857,GO:0030312,GO:0030313,GO:0031975,GO:0034219,GO:0044462,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944		ko:K14062					ko00000,ko02000	1.B.1.1		iECO26_1355.ECO26_1980,iZ_1308.Z2333	Bacteria	1MVRY@1224,1RNBS@1236,3XN4M@561,COG3203@1,COG3203@2	NA|NA|NA	M	Outer membrane protein N
C1_01822	754331.AEME01000001_gene649	5.2e-72	276.9	Escherichia	uspF	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0006950,GO:0006979,GO:0007155,GO:0008144,GO:0008150,GO:0017076,GO:0022610,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0050896,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K11932,ko:K14061					ko00000				Bacteria	1RI97@1224,1SYU1@1236,3XRKX@561,COG0589@1,COG0589@2	NA|NA|NA	T	Universal stress protein family
C1_01823	1410653.JHVC01000004_gene3242	1.1e-08	66.6	Clostridiaceae													Bacteria	1VFIW@1239,24P4M@186801,2DPCE@1,331HP@2,36M6G@31979	NA|NA|NA		
C1_01824	1121889.AUDM01000018_gene1257	9.9e-24	117.5	Flavobacterium													Bacteria	1IDRX@117743,2BMYA@1,2NZ26@237,32GI2@2,4PD8B@976	NA|NA|NA		
C1_01825	10726.FIBL1_BPT5	2.6e-196	693.0	Siphoviridae		GO:0005575,GO:0008150,GO:0016032,GO:0019012,GO:0019058,GO:0019062,GO:0022610,GO:0039638,GO:0044403,GO:0044406,GO:0044409,GO:0044411,GO:0044419,GO:0044423,GO:0044650,GO:0051701,GO:0051704,GO:0051828,GO:0051830,GO:0085027,GO:0098015,GO:0098024											Viruses	4QAK6@10239,4QKKV@10699,4QPBY@28883,4QXAR@35237	NA|NA|NA	S	peptidoglycan catabolic process
C1_01826	481805.EcolC_2110	1.1e-104	386.0	Escherichia	ompX			ko:K11934					ko00000,ko02000	1.B.6.2.1			Bacteria	1RH8M@1224,1SE1S@1236,3XRK1@561,COG3637@1,COG3637@2	NA|NA|NA	M	Enterobacterial Ail/Lom protein
C1_01827	199310.c3154	0.0	2274.6	Gammaproteobacteria													Bacteria	1MXXZ@1224,1RNFD@1236,COG4733@1,COG4733@2	NA|NA|NA	NT	Phage-related protein, tail component
C1_01828	754331.AEME01000001_gene4013	7.6e-89	333.2	Escherichia													Bacteria	1RFBS@1224,1S4AY@1236,3XRHR@561,COG4723@1,COG4723@2	NA|NA|NA	S	Bacteriophage lambda tail assembly protein I
C1_01829	1440052.EAKF1_ch4484	5.6e-117	426.8	Escherichia	JD73_18915		3.5.1.28	ko:K01449,ko:K21471			R04112	RC00064,RC00141	ko00000,ko01000,ko01002,ko01011				Bacteria	1N05J@1224,1RPP6@1236,3XPYI@561,COG0791@1,COG0791@2,COG1310@1,COG1310@2	NA|NA|NA	M	JAB/MPN domain
C1_01830	754331.AEME01000001_gene3964	4.4e-129	467.2	Escherichia	JD73_18910												Bacteria	1N0JB@1224,1S2IE@1236,3XQ3K@561,COG4672@1,COG4672@2	NA|NA|NA	S	Phage minor tail protein L
C1_01831	1197719.A464_1009	8e-24	116.3	Salmonella													Bacteria	1N8H3@1224,1SCEF@1236,3ZMQC@590,COG4718@1,COG4718@2	NA|NA|NA	S	Phage minor tail protein
C1_01832	754331.AEME01000001_gene3965	0.0	1856.3	Escherichia	sca1												Bacteria	1MU81@1224,1RS6P@1236,3XQ8T@561,COG1196@1,COG1196@2,COG5281@1,COG5281@2	NA|NA|NA	D	Prophage tail length tape measure protein
C1_01833	754331.AEME01000001_gene3966	1e-75	289.3	Escherichia													Bacteria	1RCZC@1224,1S5R3@1236,2DKUB@1,30C1N@2,3XQZQ@561	NA|NA|NA		
C1_01834	754331.AEME01000001_gene3967	3e-141	508.1	Gammaproteobacteria													Bacteria	1MVYC@1224,1T12D@1236,COG5492@1,COG5492@2	NA|NA|NA	N	domain, Protein
C1_01835	754331.AEME01000001_gene3968	2e-59	235.0	Gammaproteobacteria													Bacteria	1RGMP@1224,1S5EK@1236,29RTM@1,30CXH@2	NA|NA|NA	S	Bacteriophage related domain of unknown function
C1_01836	754331.AEME01000001_gene3969	5.4e-65	253.4	Gammaproteobacteria													Bacteria	1N5KK@1224,1SAWM@1236,2DQJA@1,32UP8@2	NA|NA|NA		
C1_01837	754331.AEME01000001_gene3970	2.3e-63	248.1	Gammaproteobacteria													Bacteria	1N5PX@1224,1S8TT@1236,2EFF0@1,3397V@2	NA|NA|NA		
C1_01838	754331.AEME01000001_gene3970	3.3e-65	254.2	Gammaproteobacteria													Bacteria	1N5PX@1224,1S8TT@1236,2EFF0@1,3397V@2	NA|NA|NA		
C1_01839	754331.AEME01000001_gene3971	8.6e-26	122.1	Escherichia													Bacteria	1RKF4@1224,1S7TD@1236,2C2DC@1,31G95@2,3XREG@561	NA|NA|NA		
C1_01840	754331.AEME01000001_gene3972	4.2e-206	723.8	Escherichia													Bacteria	1NNYY@1224,1RMDR@1236,2C377@1,2Z7II@2,3XQST@561	NA|NA|NA	S	P22 coat protein - gene protein 5
C1_01841	754331.AEME01000001_gene3973	3.8e-134	484.2	Escherichia													Bacteria	1RC9Z@1224,1RPQ5@1236,28IY5@1,2Z8VY@2,3XQGZ@561	NA|NA|NA		
C1_01842	754331.AEME01000001_gene3974	1.7e-204	718.4	Escherichia													Bacteria	1PUNX@1224,1S0QA@1236,3XQM5@561,COG2369@1,COG2369@2	NA|NA|NA	S	Head morphogenesis protein
C1_01843	754331.AEME01000001_gene3975	6.9e-267	926.0	Escherichia													Bacteria	1NJD6@1224,1RY86@1236,28IAN@1,2Z8D8@2,3XQ80@561	NA|NA|NA	S	Domain of unknown function (DUF4055)
C1_01844	1115515.EV102420_38_00210	2.5e-234	817.8	Escherichia													Bacteria	1MWGP@1224,1RMTH@1236,3XQV7@561,COG1783@1,COG1783@2	NA|NA|NA	S	Terminase RNaseH-like domain
C1_01845	754331.AEME01000001_gene3977	4.2e-195	687.2	Escherichia				ko:K07474					ko00000				Bacteria	1R986@1224,1RYYD@1236,3XQYF@561,COG3728@1,COG3728@2	NA|NA|NA	L	Terminase small subunit
C1_01847	508419.F8J156_9CAUD	6.6e-48	198.0	Siphoviridae													Viruses	4QCFZ@10239,4QMFF@10699,4QRJS@28883,4QVRS@35237	NA|NA|NA		
C1_01848	754331.AEME01000001_gene3980	6.4e-145	520.0	Escherichia	ynaK												Bacteria	1PCSS@1224,1TKI7@1236,3XR45@561,COG1475@1,COG1475@2	NA|NA|NA	K	ParB-like nuclease domain
C1_01849	316407.1742227	3.7e-268	930.2	Escherichia	trkH	GO:0003674,GO:0005215,GO:0005216,GO:0005261,GO:0005267,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015267,GO:0015318,GO:0015672,GO:0016020,GO:0016021,GO:0022803,GO:0022838,GO:0022857,GO:0022890,GO:0030001,GO:0030955,GO:0031224,GO:0031226,GO:0031420,GO:0034220,GO:0043167,GO:0043169,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098660,GO:0098662		ko:K03498					ko00000,ko02000	2.A.38.1,2.A.38.4		iECDH1ME8569_1439.ECDH1ME8569_1308,iSFV_1184.SFV_3651	Bacteria	1MUIJ@1224,1RQNY@1236,3XNK1@561,COG0168@1,COG0168@2	NA|NA|NA	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA
C1_01850	362663.ECP_1161	2.5e-72	278.1	Escherichia	rzpD			ko:K14744					ko00000,ko01000				Bacteria	1N10F@1224,1S95X@1236,2DP4N@1,330HV@2,3XPIW@561	NA|NA|NA	S	Necessary for host cell lysis. It is believed to code for an endopeptidase that cleaves the amino-carboxyl cross-link between the diaminopimelic acid and D-alanine residues in the murein component of the bacterial cell wall (By similarity)
C1_01851	199310.c1562	5.3e-89	333.6	Escherichia	rrrD	GO:0001906,GO:0001907,GO:0003674,GO:0003796,GO:0003824,GO:0004553,GO:0008150,GO:0016032,GO:0016787,GO:0016798,GO:0019048,GO:0019058,GO:0019076,GO:0031640,GO:0035821,GO:0035890,GO:0035891,GO:0039633,GO:0040011,GO:0044003,GO:0044004,GO:0044364,GO:0044403,GO:0044419,GO:0044659,GO:0044661,GO:0051701,GO:0051704,GO:0051817,GO:0051818,GO:0051883,GO:0052126,GO:0052192,GO:0061783	3.2.1.17	ko:K01185					ko00000,ko01000				Bacteria	1MZJD@1224,1S6BA@1236,3XPV0@561,COG3772@1,COG3772@2	NA|NA|NA	G	Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity. Exhibits lytic activity against E.coli and S.typhi cell wall substrate
C1_01852	199310.c1561	2.6e-32	144.1	Escherichia	essD	GO:0001906,GO:0001907,GO:0008150,GO:0016032,GO:0019048,GO:0019058,GO:0019076,GO:0031640,GO:0035821,GO:0035890,GO:0035891,GO:0039633,GO:0040011,GO:0044003,GO:0044004,GO:0044364,GO:0044403,GO:0044419,GO:0044659,GO:0044661,GO:0051701,GO:0051704,GO:0051817,GO:0051818,GO:0051883,GO:0052126,GO:0052192											Bacteria	1NAY0@1224,1SFBJ@1236,2E3SS@1,32YQ9@2,3XQ2B@561	NA|NA|NA	S	Lysis protein S homolog from lambdoid prophage
C1_01853	155864.EDL933_p0089	8.1e-64	249.6	Gammaproteobacteria	tolA			ko:K03646					ko00000,ko02000	2.C.1.2			Bacteria	1RIWN@1224,1S8DR@1236,COG3064@1,COG3064@2	NA|NA|NA	M	TolA C-terminal
C1_01854	155864.EDL933_0819	2.7e-20	105.1	Escherichia	tolA	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0009719,GO:0009987,GO:0010033,GO:0010243,GO:0015031,GO:0015833,GO:0015893,GO:0016020,GO:0016021,GO:0016032,GO:0017038,GO:0019058,GO:0019904,GO:0030260,GO:0031224,GO:0031226,GO:0032153,GO:0033036,GO:0042221,GO:0042493,GO:0042886,GO:0042891,GO:0043213,GO:0044403,GO:0044409,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046677,GO:0046678,GO:0046718,GO:0046790,GO:0050896,GO:0051179,GO:0051234,GO:0051301,GO:0051701,GO:0051704,GO:0051716,GO:0051806,GO:0051828,GO:0070887,GO:0071236,GO:0071237,GO:0071310,GO:0071417,GO:0071495,GO:0071702,GO:0071705,GO:0071944,GO:0097718,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701		ko:K03646					ko00000,ko02000	2.C.1.2			Bacteria	1MVQS@1224,1RP2V@1236,3XNNC@561,COG3064@1,COG3064@2	NA|NA|NA	U	Involved in the TonB-independent uptake of group A colicins (colicins A, E1, E2, E3, and K). Necessary for the colicins to reach their respective targets after initial binding to the bacteria. Also involved in the translocation of bacteriophage DNA
C1_01855	198214.SF1355	5.5e-87	327.0	Gammaproteobacteria													Bacteria	1Q0BK@1224,1S10W@1236,28MFS@1,2ZAT6@2	NA|NA|NA	S	Protein of unknown function (DUF1133)
C1_01856	155864.EDL933_2301	1.1e-46	192.2	Escherichia													Bacteria	1N2ZM@1224,1S9DB@1236,2D7I9@1,32TP3@2,3XR1W@561	NA|NA|NA	S	Protein of unknown function (DUF1364)
C1_01857	155864.EDL933_2302	6e-111	406.8	Escherichia													Bacteria	1R6SC@1224,1RR2K@1236,28KZZ@1,2ZAF4@2,3XPNY@561	NA|NA|NA	S	Protein of unknown function (DUF1367)
C1_01858	10730.Q9XJM4_BP933	1.7e-20	104.8	Podoviridae													Viruses	4QE3W@10239,4QNCP@10744,4QRRS@28883,4QZNZ@35237	NA|NA|NA	S	Hok/gef family
C1_01859	575586.HMPREF0016_00213	5.9e-126	457.6	Moraxellaceae													Bacteria	1MU9G@1224,1RM9G@1236,3NIRP@468,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
C1_01860	1500897.JQNA01000002_gene3972	3.2e-55	221.9	Burkholderiaceae	chaC	GO:0001539,GO:0003674,GO:0003824,GO:0003839,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006518,GO:0006575,GO:0006749,GO:0006751,GO:0006790,GO:0006807,GO:0006928,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0034641,GO:0040011,GO:0042219,GO:0043171,GO:0043603,GO:0044237,GO:0044248,GO:0044273,GO:0044424,GO:0044464,GO:0048870,GO:0051179,GO:0051186,GO:0051187,GO:0051674,GO:0071704,GO:0071973,GO:0097588,GO:1901564,GO:1901565,GO:1901575		ko:K07232					ko00000				Bacteria	1K2D5@119060,1QA7D@1224,2VQKU@28216,COG3703@1,COG3703@2	NA|NA|NA	P	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
C1_01861	35703.DQ02_04375	1.9e-158	565.1	Gammaproteobacteria	abaB												Bacteria	1QVFF@1224,1RMUA@1236,COG0583@1,COG0583@2	NA|NA|NA	K	Transcriptional regulator
C1_01862	1006000.GKAS_03916	3.1e-213	747.7	Gammaproteobacteria		GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009405,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0051704											Bacteria	1MXTM@1224,1RNYZ@1236,COG4325@1,COG4325@2	NA|NA|NA	S	Membrane
C1_01863	716541.ECL_02496	0.0	1261.5	Enterobacter	betT			ko:K02168					ko00000,ko02000	2.A.15.1.3,2.A.15.1.4			Bacteria	1MV0K@1224,1RP3E@1236,3X07T@547,COG1292@1,COG1292@2	NA|NA|NA	P	BCCT, betaine/carnitine/choline family transporter
C1_01864	502347.ESCAB7627_3532	2.1e-65	255.0	Escherichia													Bacteria	1RD4K@1224,1S3VY@1236,29XZ3@1,30JRR@2,3XQB1@561	NA|NA|NA	S	Bacterial protein of unknown function (DUF977)
C1_01865	199310.c1412	5.2e-174	617.1	Bacteria													Bacteria	COG3756@1,COG3756@2	NA|NA|NA		
C1_01866	199310.c1411	1.9e-74	285.0	Escherichia													Bacteria	1QIFW@1224,1TGA8@1236,2BPMT@1,32IEU@2,3XQ8A@561	NA|NA|NA	S	Putative bacterial toxin ydaT
C1_01867	1453496.AT03_13400	5.4e-22	110.2	Gammaproteobacteria	croE												Bacteria	1NBCG@1224,1SIAE@1236,COG4197@1,COG4197@2	NA|NA|NA	S	Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT
C1_01868	199310.c1410	2.7e-70	271.2	Gammaproteobacteria	cI		3.4.21.88	ko:K01356		M00729			ko00000,ko00002,ko01000,ko01002,ko03400				Bacteria	1N8VW@1224,1SPWY@1236,COG1974@1,COG1974@2	NA|NA|NA	KT	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C1_01869	155864.EDL933_2317	2.2e-18	97.1	Escherichia													Bacteria	1QIS1@1224,1TGME@1236,2AWTG@1,31NQI@2,3XRB0@561	NA|NA|NA	S	UBA-like domain
C1_01870	155864.EDL933_2318	1.9e-21	107.5	Escherichia													Bacteria	1QIQB@1224,1TGJN@1236,2E72D@1,31KUZ@2,3XR7K@561	NA|NA|NA	S	Protein of unknown function (DUF1391)
C1_01872	316407.1742222	4e-36	156.8	Gammaproteobacteria	kilR	GO:0008150,GO:0042221,GO:0046677,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051302,GO:0051782,GO:0065007											Bacteria	1N15W@1224,1SC5P@1236,2D91W@1,32TSE@2	NA|NA|NA	S	Causes inhibition of cell division. At high levels of expression, can also abolish the rod shape of the cells. Division inhibition by KilR can be relieved by overexpression of the cell division protein FtsZ
C1_01873	155864.EDL933_2321	3.2e-25	120.2	Gammaproteobacteria	ydaE	GO:0003674,GO:0005488,GO:0008270,GO:0043167,GO:0043169,GO:0046872,GO:0046914											Bacteria	1PAM6@1224,1SV9M@1236,2DFM4@1,2ZS9G@2	NA|NA|NA	S	zinc ion binding
C1_01874	316407.1742220	6.4e-44	183.0	Escherichia	racC												Bacteria	1RKJN@1224,1S6PX@1236,2C72K@1,32RI9@2,3XR0H@561	NA|NA|NA		
C1_01875	316407.85674919	0.0	1744.6	Escherichia	recE	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005488,GO:0005515,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008309,GO:0008409,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0034641,GO:0035312,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0051908,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	2.7.7.7,3.6.4.12	ko:K02335,ko:K02342,ko:K03654,ko:K03722,ko:K10906	ko00230,ko00240,ko01100,ko03018,ko03030,ko03410,ko03420,ko03430,ko03440,map00230,map00240,map01100,map03018,map03030,map03410,map03420,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Bacteria	1QWC0@1224,1T2TC@1236,3XPTI@561,COG0847@1,COG0847@2	NA|NA|NA	L	Is involved in the RecE pathway of recombination. Catalyzes the degradation of double-stranded DNA. Acts progressively in a 5' to 3' direction, releasing 5'- phosphomononucleotides. Has a strong preference for linear duplex substrate DNA and appears to be unable to initiate degradation from single-stranded breaks in DNA
C1_01876	316407.1742215	1.1e-147	529.3	Escherichia	recT	GO:0000724,GO:0000725,GO:0000731,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0018130,GO:0019438,GO:0032392,GO:0032508,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043150,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071103,GO:0071704,GO:0071840,GO:0071897,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901576		ko:K07455					ko00000,ko03400				Bacteria	1R6DB@1224,1RZZ3@1236,3XN6G@561,COG3723@1,COG3723@2	NA|NA|NA	L	Binds to single-stranded DNA and also promotes the renaturation of complementary single-stranded DNA. Function in recombination. Has a function
C1_01877	316407.1742213	2.4e-30	137.5	Gammaproteobacteria	ydaC	GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:1901360		ko:K19780					ko00000,ko02048				Bacteria	1P1BF@1224,1SSR7@1236,2FGCN@1,3488V@2	NA|NA|NA	J	response to antibiotic
C1_01878	155864.EDL933_2327	3.9e-36	156.8	Escherichia	ydaQ	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0008150,GO:0016032,GO:0019042,GO:0019045,GO:0019046,GO:0032359,GO:0043565,GO:0044403,GO:0044419,GO:0051704,GO:0097159,GO:1901363,GO:1990837											Bacteria	1NC4W@1224,1SF39@1236,2E46E@1,32Z2C@2,3XR3N@561	NA|NA|NA	S	Putative excisionase (DUF1233)
C1_01879	316407.85674917	4.1e-239	833.6	Escherichia	intR			ko:K03733,ko:K14059					ko00000,ko03036				Bacteria	1MVZB@1224,1RP4Y@1236,3XM9F@561,COG0582@1,COG0582@2	NA|NA|NA	L	Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome (By similarity)
C1_01880	155864.EDL933_2329	3.1e-178	630.9	Escherichia	ttcA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0016783,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360	6.3.4.19	ko:K04075,ko:K14058			R09597	RC02633,RC02634	ko00000,ko01000,ko03016				Bacteria	1MW5Q@1224,1RN2H@1236,3XP9A@561,COG0037@1,COG0037@2	NA|NA|NA	J	Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system
C1_01881	155864.EDL933_2330	2.4e-256	891.0	Escherichia	dbpA	GO:0000027,GO:0000166,GO:0000339,GO:0003674,GO:0003676,GO:0003723,GO:0003724,GO:0003725,GO:0003729,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006412,GO:0006413,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008135,GO:0008144,GO:0008150,GO:0008152,GO:0008186,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0010468,GO:0010501,GO:0016043,GO:0016070,GO:0016281,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033677,GO:0034458,GO:0034459,GO:0034622,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0042254,GO:0042255,GO:0042273,GO:0042623,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0060255,GO:0065003,GO:0065007,GO:0070035,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:0140098,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	3.6.4.13	ko:K05591,ko:K05592	ko03018,map03018				ko00000,ko00001,ko01000,ko03009,ko03019				Bacteria	1MU49@1224,1RQ36@1236,3XNIY@561,COG0513@1,COG0513@2	NA|NA|NA	F	DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes
C1_01883	155864.EDL933_2331	1.4e-186	658.7	Escherichia	zntB	GO:0000041,GO:0003674,GO:0005215,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008150,GO:0008324,GO:0015075,GO:0015318,GO:0015562,GO:0016020,GO:0016021,GO:0022857,GO:0022883,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0046583,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662		ko:K03284,ko:K16074					ko00000,ko02000	1.A.35.1,1.A.35.3,1.A.35.4			Bacteria	1MW8W@1224,1RRTZ@1236,3XN7N@561,COG0598@1,COG0598@2	NA|NA|NA	P	Mediates efflux of zinc ions
C1_01884	155864.EDL933_2332	6.1e-235	819.7	Escherichia	ydaM	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016740,GO:0016772,GO:0016779,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042802,GO:0043900,GO:0043902,GO:0044093,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051090,GO:0051091,GO:0051171,GO:0051252,GO:0052621,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:1900190,GO:1900192,GO:1900231,GO:1900233,GO:1903506,GO:2000112,GO:2001141	2.7.7.65	ko:K21088	ko02026,map02026				ko00000,ko00001,ko01000				Bacteria	1NAG0@1224,1RPKX@1236,3XN91@561,COG2199@1,COG3706@2	NA|NA|NA	T	Part of a 2 protein system that seems to be dedicated to regulate transcription of csgD. The CsdG protein in turn regulates expression of adhesive curli fimbriae genes csgEFG, csgBAC ymaD and adrA (yaic). Activity of this protein is antagonized by the phosphodiesterase Gmr (YciR). In vitro has weak diguanylate cyclase activity. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria
C1_01885	155864.EDL933_2333	2.3e-104	384.8	Escherichia	ydaL	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363											Bacteria	1RH34@1224,1S6B5@1236,3XMKT@561,COG2840@1,COG2840@2	NA|NA|NA	L	endodeoxyribonuclease activity
C1_01886	155864.EDL933_2334	6.2e-168	596.7	Escherichia	abgR			ko:K07592,ko:K14057					ko00000,ko03000				Bacteria	1P2I1@1224,1RN0V@1236,3XRJC@561,COG0583@1,COG0583@2	NA|NA|NA	K	transcriptional regulator
C1_01887	481805.EcolC_2287	1.9e-247	861.3	Escherichia	abgA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009109,GO:0009111,GO:0009397,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0019439,GO:0019752,GO:0034641,GO:0042219,GO:0042365,GO:0042558,GO:0042560,GO:0042737,GO:0043436,GO:0043603,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0046483,GO:0046655,GO:0046657,GO:0046700,GO:0046982,GO:0046983,GO:0051186,GO:0051187,GO:0071704,GO:0071713,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575		ko:K12940,ko:K12941					ko00000,ko01002				Bacteria	1MUIV@1224,1RRJI@1236,3XRJ1@561,COG1473@1,COG1473@2	NA|NA|NA	E	Component of the p-aminobenzoyl-glutamate hydrolase multicomponent enzyme system which catalyzes the cleavage of p- aminobenzoyl-glutamate (PABA-GLU) to form p-aminobenzoate (PABA) and glutamate. AbgAB does not degrade dipeptides and the physiological role of abgABT should be clarified
C1_01888	316407.85674911	1.8e-278	964.5	Escherichia	abgB	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009109,GO:0009111,GO:0009397,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0019439,GO:0019752,GO:0034641,GO:0042219,GO:0042365,GO:0042558,GO:0042560,GO:0042737,GO:0043436,GO:0043603,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0046483,GO:0046655,GO:0046657,GO:0046700,GO:0046982,GO:0046983,GO:0051186,GO:0051187,GO:0071704,GO:0071713,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575		ko:K12940,ko:K12941					ko00000,ko01002				Bacteria	1MX6N@1224,1RP3N@1236,3XR4V@561,COG1473@1,COG1473@2	NA|NA|NA	S	Component of the p-aminobenzoyl-glutamate hydrolase multicomponent enzyme system which catalyzes the cleavage of p- aminobenzoyl-glutamate (PABA-GLU) to form p-aminobenzoate (PABA) and glutamate. AbgAB does not degrade dipeptides and the physiological role of abgABT should be clarified
C1_01889	481805.EcolC_2289	3e-276	957.2	Gammaproteobacteria	abgT	GO:0003674,GO:0005215,GO:0005310,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006857,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015291,GO:0015318,GO:0015558,GO:0015711,GO:0015814,GO:0015833,GO:0015849,GO:0016020,GO:0022804,GO:0022857,GO:0034220,GO:0035442,GO:0035672,GO:0035673,GO:0042886,GO:0042887,GO:0042938,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071916,GO:0071944,GO:0072337,GO:0072349,GO:0098656,GO:1903825,GO:1904680,GO:1905039		ko:K12942					ko00000				Bacteria	1MUJ1@1224,1RMAI@1236,COG2978@1,COG2978@2	NA|NA|NA	H	transporter
C1_01890	469008.B21_01322	1.4e-95	355.5	Escherichia	ogt	GO:0003674,GO:0003824,GO:0003908,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	2.1.1.63	ko:K00567,ko:K10778					ko00000,ko01000,ko03000,ko03400				Bacteria	1N2YQ@1224,1S68H@1236,3XMKI@561,COG0350@1,COG0350@2	NA|NA|NA	J	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C1_01891	155864.EDL933_2342	4.2e-138	497.3	Escherichia	fnr	GO:0000302,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009061,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010035,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0015980,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0042221,GO:0042493,GO:0043565,GO:0044212,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0045893,GO:0045935,GO:0048037,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0060255,GO:0065007,GO:0071731,GO:0080090,GO:0097159,GO:0097366,GO:0140110,GO:1901363,GO:1901698,GO:1901700,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141		ko:K01420					ko00000,ko03000				Bacteria	1MVGE@1224,1RPTB@1236,3XMYG@561,COG0664@1,COG0664@2	NA|NA|NA	K	Global transcription factor that controls the expression of over 100 target genes in response to anoxia. It facilitates the adaptation to anaerobic growth conditions by regulating the expression of gene products that are involved in anaerobic energy metabolism. When the terminal electron acceptor, O(2), is no longer available, it represses the synthesis of enzymes involved in aerobic respiration and increases the synthesis of enzymes required for anaerobic respiration
C1_01892	155864.EDL933_2343	1.3e-181	642.1	Escherichia	uspE	GO:0000302,GO:0001539,GO:0006928,GO:0006950,GO:0006979,GO:0008150,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0033554,GO:0034599,GO:0034614,GO:0034644,GO:0035690,GO:0040011,GO:0042221,GO:0042493,GO:0042542,GO:0042710,GO:0044010,GO:0044764,GO:0046677,GO:0048870,GO:0050896,GO:0051179,GO:0051674,GO:0051704,GO:0051716,GO:0070301,GO:0070887,GO:0071214,GO:0071236,GO:0071478,GO:0071482,GO:0071973,GO:0097237,GO:0097588,GO:0104004,GO:1901700,GO:1901701		ko:K14055					ko00000				Bacteria	1MVZS@1224,1RPAE@1236,3XPAC@561,COG0589@1,COG0589@2	NA|NA|NA	T	Required for resistance to DNA-damaging agents
C1_01893	155864.EDL933_2344	6e-36	156.4	Escherichia	ynaJ												Bacteria	1N0ZR@1224,1S9Y9@1236,3XPZ8@561,COG3182@1,COG3182@2	NA|NA|NA	S	Protein of unknown function (DUF2534)
C1_01894	155864.EDL933_2345	1.2e-188	665.6	Escherichia	ynaI	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0042802,GO:0044464,GO:0071944		ko:K16052					ko00000,ko02000	1.A.23.4			Bacteria	1MXD2@1224,1RNUB@1236,3XNAZ@561,COG0668@1,COG0668@2	NA|NA|NA	M	Belongs to the MscS (TC 1.A.23) family
C1_01895	316407.85674908	0.0	1090.1	Escherichia	mppA	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006810,GO:0006811,GO:0006820,GO:0006857,GO:0006869,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010876,GO:0015711,GO:0015718,GO:0015721,GO:0015833,GO:0015849,GO:0015850,GO:0030288,GO:0030313,GO:0031975,GO:0033036,GO:0033218,GO:0042277,GO:0042597,GO:0042886,GO:0042939,GO:0044464,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0061077,GO:0071702,GO:0071705,GO:1900750		ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439			ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25		iECNA114_1301.ECNA114_1414,iECSF_1327.ECSF_1224,iUMNK88_1353.UMNK88_1667	Bacteria	1P91R@1224,1RN57@1236,3XN8G@561,COG4166@1,COG4166@2	NA|NA|NA	E	Periplasmic murein peptide-binding protein
C1_01896	481805.EcolC_2296	7.3e-161	573.2	Escherichia	ycjZ	GO:0001539,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006928,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0040011,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0048870,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051179,GO:0051252,GO:0051253,GO:0051674,GO:0060255,GO:0065007,GO:0071704,GO:0071973,GO:0071978,GO:0080090,GO:0090304,GO:0097159,GO:0097588,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141											Bacteria	1MU2E@1224,1RQ66@1236,3XPH8@561,COG0583@1,COG0583@2	NA|NA|NA	K	Transcriptional regulator
C1_01897	316407.85674907	3.2e-172	610.9	Escherichia	ycjY	GO:0008150,GO:0009987,GO:0051301		ko:K06889					ko00000				Bacteria	1MUCD@1224,1RP4I@1236,3XPND@561,COG1073@1,COG1073@2	NA|NA|NA	S	cell division
C1_01898	82995.CR62_01095	8.1e-155	553.1	Serratia				ko:K06889					ko00000				Bacteria	1MUCD@1224,1RP4I@1236,4013F@613,COG1073@1,COG1073@2	NA|NA|NA	S	Dienelactone hydrolase family
C1_01899	362663.ECP_1380	8.2e-114	416.4	Gammaproteobacteria													Bacteria	1MVBE@1224,1RY6N@1236,COG0702@1,COG0702@2	NA|NA|NA	GM	NAD(P)H-binding
C1_01900	155864.EDL933_2353	1.2e-140	505.8	Escherichia	mpaA	GO:0000270,GO:0003674,GO:0003824,GO:0004040,GO:0004180,GO:0004181,GO:0005488,GO:0006022,GO:0006026,GO:0006027,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0009050,GO:0009056,GO:0009057,GO:0009253,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0019538,GO:0030203,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0046872,GO:0046914,GO:0061473,GO:0070011,GO:0071704,GO:0140096,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575		ko:K14054					ko00000			iEC55989_1330.EC55989_1490,iECO103_1326.ECO103_1491	Bacteria	1N9AY@1224,1RRGU@1236,3XN4D@561,COG2866@1,COG2866@2	NA|NA|NA	E	murein tripeptide carboxypeptidase activity
C1_01901	481805.EcolC_2300	2e-177	628.2	Escherichia	ycjG	GO:0003674,GO:0003824,GO:0016853,GO:0016854,GO:0016855	5.1.1.20	ko:K19802			R10938	RC03309	ko00000,ko01000			iEC042_1314.EC042_1441,iECUMN_1333.ECUMN_1620	Bacteria	1MW76@1224,1RMKS@1236,3XNFU@561,COG4948@1,COG4948@2	NA|NA|NA	M	Belongs to the mandelate racemase muconate lactonizing enzyme family
C1_01902	155864.EDL933_2355	8.7e-87	326.2	Escherichia	tpx	GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009405,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0015036,GO:0016209,GO:0016491,GO:0016667,GO:0016671,GO:0016684,GO:0019725,GO:0020012,GO:0030312,GO:0030682,GO:0032843,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0051920,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071944,GO:0075136,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.11.1.15	ko:K11065					ko00000,ko01000				Bacteria	1RAJ9@1224,1S263@1236,3XN62@561,COG2077@1,COG2077@2	NA|NA|NA	O	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C1_01903	316407.1742168	8e-293	1012.3	Escherichia	tyrR	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K03721					ko00000,ko03000				Bacteria	1QTS3@1224,1RNAI@1236,3XN47@561,COG3283@1,COG3283@2	NA|NA|NA	K	Involved in transcriptional regulation of aromatic amino acid biosynthesis and transport. Modulates the expression of at least 8 unlinked operons. Seven of these operons are regulated in response to changes in the concentration of the three aromatic amino acids (phenylalanine, tyrosine and tryptophan). These amino acids are suggested to act as co-effectors which bind to the TyrR protein to form an active regulatory protein. In most cases TyrR causes negative regulation, but positive effects on the tyrP gene have been observed at high phenylalanine concentrations
C1_01904	199310.c1794	2e-197	694.9	Escherichia	ycjF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K06883,ko:K08990					ko00000				Bacteria	1MU8S@1224,1RND9@1236,3XNN9@561,COG3768@1,COG3768@2	NA|NA|NA	S	UPF0283 membrane protein YcjF
C1_01905	155864.EDL933_2358	4e-275	953.4	Escherichia	ycjX			ko:K06918					ko00000				Bacteria	1MX6E@1224,1RQ05@1236,3XMK8@561,COG3106@1,COG3106@2	NA|NA|NA	S	ATP binding
C1_01906	316407.1742164	3.2e-181	641.0	Escherichia	ycjW	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576											Bacteria	1R608@1224,1RZY5@1236,3XQAW@561,COG1609@1,COG1609@2	NA|NA|NA	K	Transcriptional regulator
C1_01907	316407.85674903	7.3e-185	652.9	Escherichia	ompG	GO:0003674,GO:0005215,GO:0005363,GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0008643,GO:0009279,GO:0015144,GO:0015154,GO:0015157,GO:0015267,GO:0015288,GO:0015478,GO:0015481,GO:0015766,GO:0015768,GO:0015772,GO:0016020,GO:0016021,GO:0019867,GO:0022803,GO:0022829,GO:0022857,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031975,GO:0034219,GO:0044425,GO:0044462,GO:0044464,GO:0045203,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944		ko:K14053					ko00000,ko02000	1.B.21.1.1		iECNA114_1301.ECNA114_1509	Bacteria	1R636@1224,1RUMF@1236,28K0Z@1,2Z9QU@2,3XQPG@561	NA|NA|NA	M	Outer membrane protein G
C1_01908	754331.AEME01000001_gene1812	1e-201	709.1	Escherichia	msmK			ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606			ko00000,ko00001,ko00002,ko02000	3.A.1.1			Bacteria	1MU3I@1224,1RM9E@1236,3XMFP@561,COG3842@1,COG3842@2	NA|NA|NA	P	ATP-binding protein YcjV
C1_01909	316407.1742154	2e-115	421.8	Escherichia	pgmB	GO:0000287,GO:0003674,GO:0003824,GO:0004805,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008801,GO:0009058,GO:0009292,GO:0009294,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016853,GO:0016866,GO:0016868,GO:0019203,GO:0030312,GO:0033554,GO:0034637,GO:0040007,GO:0042221,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0046351,GO:0046677,GO:0046872,GO:0050896,GO:0051704,GO:0051716,GO:0071704,GO:0071944,GO:1901576	2.4.1.64,3.1.3.12,3.2.1.28,5.4.2.6	ko:K01087,ko:K01194,ko:K01838,ko:K05342	ko00500,ko01100,map00500,map01100		R00010,R02727,R02728,R02778,R11310	RC00017,RC00049,RC00408	ko00000,ko00001,ko00537,ko01000		GH37,GH65		Bacteria	1NDNW@1224,1S1Z7@1236,3XQBP@561,COG0637@1,COG0637@2	NA|NA|NA	S	Catalyzes the interconversion of D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), forming beta-D-glucose 1,6- (bis)phosphate (beta-G16P) as an intermediate. The beta- phosphoglucomutase (Beta-PGM) acts on the beta-C(1) anomer of G1P. Glucose or lactose are used in preference to maltose, which is only utilized after glucose or lactose has been exhausted. It plays a key role in the regulation of the flow of carbohydrate intermediates in glycolysis and the formation of the sugar nucleotide UDP-glucose
C1_01910	754331.AEME01000001_gene1810	0.0	1510.0	Escherichia	ycjT	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0016787,GO:0030312,GO:0044464,GO:0071944	2.4.1.230	ko:K04844,ko:K10231					ko00000,ko01000		GH65		Bacteria	1MWJE@1224,1RPN6@1236,3XPHE@561,COG1554@1,COG1554@2	NA|NA|NA	G	carbohydrate binding
C1_01911	316407.1742152	1.2e-202	712.2	Escherichia	ycjS												Bacteria	1NKUI@1224,1RU6K@1236,3XMTS@561,COG0673@1,COG0673@2	NA|NA|NA	S	oxidoreductase activity
C1_01912	316407.85674901	5.6e-149	533.5	Escherichia	ycjR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Bacteria	1MV2C@1224,1RSA5@1236,3XQ5Z@561,COG1082@1,COG1082@2	NA|NA|NA	G	isomerase activity
C1_01913	316407.85674900	2.9e-201	707.6	Escherichia	ycjQ												Bacteria	1QV3S@1224,1RRI1@1236,3XPGB@561,COG1063@1,COG1063@2	NA|NA|NA	E	oxidoreductase activity
C1_01914	155864.EDL933_2367	2.9e-76	291.2	Escherichia	ycjP	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02026		M00207			ko00000,ko00002,ko02000	3.A.1.1			Bacteria	1N4I0@1224,1SYM3@1236,3XNBN@561,COG0395@1,COG0395@2	NA|NA|NA	P	ABC transporter permease protein YcjP
C1_01915	316407.1742150	5.9e-60	236.9	Escherichia	ycjP	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02026		M00207			ko00000,ko00002,ko02000	3.A.1.1			Bacteria	1N4I0@1224,1SYM3@1236,3XNBN@561,COG0395@1,COG0395@2	NA|NA|NA	P	ABC transporter permease protein YcjP
C1_01916	198214.SF1317	1.5e-158	565.5	Gammaproteobacteria	ycjO	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K02025,ko:K02026,ko:K05814,ko:K10109,ko:K15771	ko02010,map02010	M00194,M00198,M00207,M00491			ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.1,3.A.1.1.16,3.A.1.1.2,3.A.1.1.22,3.A.1.1.3		iSFxv_1172.SFxv_3786,iZ_1308.Z5631	Bacteria	1MWB7@1224,1RYUP@1236,COG1175@1,COG1175@2	NA|NA|NA	P	transporter
C1_01917	754331.AEME01000001_gene1804	3.9e-240	837.0	Escherichia	ycjN			ko:K02027		M00207			ko00000,ko00002,ko02000	3.A.1.1			Bacteria	1MVHV@1224,1RS5U@1236,3XM39@561,COG1653@1,COG1653@2	NA|NA|NA	G	Bacterial extracellular solute-binding protein
C1_01918	469008.B21_01297	0.0	1131.7	Escherichia	ycjM		2.4.1.7	ko:K00690	ko00500,map00500		R00803	RC00028	ko00000,ko00001,ko01000		GH13		Bacteria	1MVKX@1224,1RMXP@1236,3XPEB@561,COG0366@1,COG0366@2	NA|NA|NA	G	Catalyzes the reversible phosphorolysis of glucosylglycerate into alpha-D-glucose 1-phosphate (Glc1P) and D- glycerate. May be a regulator of intracellular levels of glucosylglycerate, a compatible solute that primarily protects organisms facing salt stress and very specific nutritional constraints. Cannot catalyze the phosphorolysis of sucrose
C1_01919	316407.1742138	1.6e-51	208.4	Escherichia	pspE	GO:0003674,GO:0003824,GO:0004792,GO:0005575,GO:0005623,GO:0016740,GO:0016782,GO:0016783,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464		ko:K03972					ko00000			iE2348C_1286.E2348C_1500,iECABU_c1320.ECABU_c15910,iSDY_1059.SDY_1936,ic_1306.c1779	Bacteria	1RHVM@1224,1SD9C@1236,3XPQA@561,COG0607@1,COG0607@2	NA|NA|NA	P	The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. PspE catalyzes the sulfur- transfer reaction from thiosulfate to cyanide, to form sulfite and thiocyanate. Also able to use dithiol (dithiothreitol) as an alternate sulfur acceptor. Also possesses a very low mercaptopyruvate sulfurtransferase activity
C1_01920	155864.EDL933_2375	7.7e-32	142.5	Escherichia	pspD	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009271,GO:0009605,GO:0009607,GO:0009615,GO:0016020,GO:0043207,GO:0044464,GO:0050896,GO:0051704,GO:0051707,GO:0071944,GO:0098586		ko:K03971					ko00000				Bacteria	1N8V6@1224,1SDXE@1236,2C1SN@1,32YQQ@2,3XQ0N@561	NA|NA|NA	S	The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions
C1_01921	155864.EDL933_2376	5.6e-56	223.4	Escherichia	pspC	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010556,GO:0010557,GO:0010604,GO:0016020,GO:0019222,GO:0044464,GO:0048518,GO:0050789,GO:0060255,GO:0065007,GO:0071944		ko:K03973					ko00000,ko02048,ko03000				Bacteria	1N085@1224,1S98J@1236,3XPT7@561,COG1983@1,COG1983@2	NA|NA|NA	KT	The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. PspC is involved in transcription regulation
C1_01922	155864.EDL933_2377	2.3e-31	141.0	Escherichia	pspB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03970					ko00000,ko02048				Bacteria	1N769@1224,1SCNV@1236,2CJWQ@1,32YI2@2,3XPZZ@561	NA|NA|NA	S	The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. PspB is involved in transcription regulation
C1_01923	155864.EDL933_2378	1.3e-106	392.5	Escherichia	pspA	GO:0003674,GO:0005488,GO:0005515,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006950,GO:0008150,GO:0008289,GO:0009266,GO:0009271,GO:0009408,GO:0009605,GO:0009607,GO:0009615,GO:0009628,GO:0009889,GO:0009898,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0019897,GO:0019898,GO:0031234,GO:0031323,GO:0031326,GO:0042802,GO:0043167,GO:0043168,GO:0043207,GO:0043433,GO:0044092,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0048519,GO:0050789,GO:0050794,GO:0050896,GO:0051090,GO:0051171,GO:0051252,GO:0051704,GO:0051707,GO:0060187,GO:0060255,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0098552,GO:0098562,GO:0098586,GO:1903506,GO:2000112,GO:2001141		ko:K03969					ko00000				Bacteria	1NC7S@1224,1RS0G@1236,3XMFD@561,COG1842@1,COG1842@2	NA|NA|NA	KT	The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. PspA negatively regulates expression of the pspABCDE promoter and of pspG through negative regulation of the psp-specific transcriptional activator PspF. Is also required for membrane integrity, efficient translocation and maintenance of the proton motive force
C1_01924	155864.EDL933_2379	4.8e-182	643.7	Escherichia	pspF	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043565,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141		ko:K03974,ko:K19505					ko00000,ko03000				Bacteria	1QV3T@1224,1T278@1236,3XN9C@561,COG1221@1,COG1221@2	NA|NA|NA	K	psp operon transcriptional activator
C1_01925	316407.1742132	1.3e-235	822.0	Escherichia	gabT	GO:0001505,GO:0003674,GO:0003824,GO:0003867,GO:0003992,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006576,GO:0006591,GO:0006595,GO:0006598,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009084,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009448,GO:0009450,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016769,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042133,GO:0042135,GO:0042402,GO:0042450,GO:0043167,GO:0043168,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0070279,GO:0071704,GO:0072329,GO:0097159,GO:0097164,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901607	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007			iECIAI1_1343.ECIAI1_2758,iECO111_1330.ECO111_3386,iECO26_1355.ECO26_3731,iSFxv_1172.SFxv_1480,iS_1188.S1389	Bacteria	1MWY6@1224,1RMP0@1236,3XNUA@561,COG0160@1,COG0160@2	NA|NA|NA	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C1_01926	316407.1742131	2.9e-248	864.0	Escherichia	puuB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0044424,GO:0044464,GO:0055114		ko:K09471	ko00330,ko01100,map00330,map01100	M00136	R07415	RC00062	ko00000,ko00001,ko00002,ko01000			iSDY_1059.SDY_1943,iYL1228.KPN_01017	Bacteria	1MVGP@1224,1RNJ9@1236,3XQ8J@561,COG0665@1,COG0665@2	NA|NA|NA	E	putrescine catabolic process
C1_01927	481805.EcolC_2325	1.5e-280	971.5	Escherichia	puuC	GO:0003674,GO:0003824,GO:0004030,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0034641,GO:0042402,GO:0044106,GO:0044237,GO:0055114,GO:0071704,GO:0097164,GO:1901564,GO:1901565,GO:1901575	1.2.1.3,1.2.1.54,1.2.1.99	ko:K00128,ko:K09472,ko:K12254	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135,M00136	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03177,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R07417,R07418,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000			iAF1260.b1300,iB21_1397.B21_01288,iBWG_1329.BWG_1132,iECBD_1354.ECBD_2317,iECB_1328.ECB_01277,iECDH10B_1368.ECDH10B_1417,iECDH1ME8569_1439.ECDH1ME8569_1242,iECD_1391.ECD_01277,iECW_1372.ECW_m1396,iEKO11_1354.EKO11_2550,iETEC_1333.ETEC_1404,iEcDH1_1363.EcDH1_2346,iEcHS_1320.EcHS_A1415,iJO1366.b1300,iJR904.b1300,iUMNK88_1353.UMNK88_1636,iWFL_1372.ECW_m1396,iY75_1357.Y75_RS06830	Bacteria	1MU1V@1224,1RMBQ@1236,3XQCS@561,COG1012@1,COG1012@2	NA|NA|NA	C	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid
C1_01928	1440052.EAKF1_ch0119c	1.4e-98	365.5	Gammaproteobacteria	puuR	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576		ko:K14056					ko00000,ko03000				Bacteria	1RCYA@1224,1S4B9@1236,COG1396@1,COG1396@2,COG1917@1,COG1917@2	NA|NA|NA	K	Transcriptional regulator
C1_01929	481805.EcolC_2327	2.4e-144	518.1	Escherichia	puuD	GO:0003674,GO:0003824,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0033969,GO:0034641,GO:0042402,GO:0044106,GO:0044237,GO:0071704,GO:0097164,GO:1901564,GO:1901565,GO:1901575	3.5.1.94	ko:K07010,ko:K09473	ko00330,ko01100,map00330,map01100	M00136	R07419	RC00090,RC00096	ko00000,ko00001,ko00002,ko01000,ko01002				Bacteria	1MV8E@1224,1RS51@1236,3XQRY@561,COG2071@1,COG2071@2	NA|NA|NA	S	Involved in the breakdown of putrescine via hydrolysis of the gamma-glutamyl linkage of gamma-glutamyl-gamma- aminobutyrate
C1_01930	155864.EDL933_2386	2.2e-276	957.6	Escherichia	puuA	GO:0003674,GO:0003824,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0034024,GO:0034641,GO:0042402,GO:0044106,GO:0044237,GO:0071704,GO:0097164,GO:1901564,GO:1901565,GO:1901575	6.3.1.11,6.3.1.2	ko:K01915,ko:K09470	ko00220,ko00250,ko00330,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	M00136	R00253,R07414	RC00010,RC00090,RC00096,RC02798	ko00000,ko00001,ko00002,ko01000,ko04147			iB21_1397.B21_01285,iECBD_1354.ECBD_2320,iECB_1328.ECB_01274,iECD_1391.ECD_01274,iSF_1195.SF1302	Bacteria	1MU6V@1224,1RPNZ@1236,3XQSY@561,COG0174@1,COG0174@2	NA|NA|NA	E	Involved in the breakdown of putrescine via the biosynthesis of gamma-L-glutamylputrescine. It is able to use several diamines, spermidine and spermine. Absolutely essential to utilize putrescine as both nitrogen and carbon sources and to decrease the toxicity of putrescine, which can lead to inhibition of cell growth and protein synthesis
C1_01931	198214.SF1301	2.1e-260	904.4	Gammaproteobacteria	puuP	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008324,GO:0008519,GO:0009056,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015101,GO:0015203,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015489,GO:0015672,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0016020,GO:0022804,GO:0022857,GO:0022890,GO:0033554,GO:0034220,GO:0034641,GO:0042402,GO:0044106,GO:0044237,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0072488,GO:0097164,GO:0098655,GO:0098660,GO:0098662,GO:1901564,GO:1901565,GO:1901575,GO:1902047,GO:1902600		ko:K14052					ko00000,ko02000	2.A.3.1.13		iSBO_1134.SBO_1766	Bacteria	1MXNJ@1224,1RMKV@1236,COG0531@1,COG0531@2	NA|NA|NA	E	Amino Acid
C1_01932	198214.SF1300	1.5e-39	168.3	Gammaproteobacteria	ymjA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Bacteria	1N182@1224,1SA6U@1236,2CR1B@1,32SN7@2	NA|NA|NA	S	Protein of unknown function (DUF2543)
C1_01933	481805.EcolC_2331	0.0	1101.3	Escherichia	sapA	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464		ko:K02035,ko:K12368,ko:K19226	ko01503,ko02010,ko02024,ko02030,map01503,map02010,map02024,map02030	M00239,M00324,M00739			ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.5			Bacteria	1P91R@1224,1T1RS@1236,3XMBD@561,COG4166@1,COG4166@2	NA|NA|NA	E	to a S.typhimurium protein implicated in antimicrobial peptide resistance, but the SapBCDF operon in E.coli is implicated in putrescine export
C1_01934	155864.EDL933_2391	9.2e-178	629.4	Escherichia	sapB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0008519,GO:0015075,GO:0015101,GO:0015203,GO:0015489,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0016020,GO:0022857,GO:0034220,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072488,GO:0098655,GO:1902047		ko:K19227	ko01503,ko02010,map01503,map02010	M00739			ko00000,ko00001,ko00002,ko02000	3.A.1.5.5			Bacteria	1QUAU@1224,1T1RR@1236,3XM3Z@561,COG4168@1,COG4168@2	NA|NA|NA	V	permease protein sapB
C1_01935	198214.SF1297	7.2e-161	573.2	Gammaproteobacteria	sapC	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0008519,GO:0015075,GO:0015101,GO:0015203,GO:0015489,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0016020,GO:0022857,GO:0034220,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072488,GO:0098655,GO:1902047		ko:K19228	ko01503,ko02010,map01503,map02010	M00739			ko00000,ko00001,ko00002,ko02000	3.A.1.5.5			Bacteria	1QUAT@1224,1T1RQ@1236,COG4171@1,COG4171@2	NA|NA|NA	V	peptide transport system, permease
C1_01936	155864.EDL933_2393	6.7e-192	676.4	Escherichia	sapD	GO:0000166,GO:0003674,GO:0005215,GO:0005488,GO:0005524,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008144,GO:0008150,GO:0008324,GO:0008519,GO:0009987,GO:0015075,GO:0015101,GO:0015203,GO:0015489,GO:0015672,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0017076,GO:0022857,GO:0030001,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034220,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071804,GO:0071805,GO:0072488,GO:0097159,GO:0097367,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901363,GO:1902047		ko:K19229	ko01503,ko02010,map01503,map02010	M00739			ko00000,ko00001,ko00002,ko02000	3.A.1.5.5		iYL1228.KPN_01288	Bacteria	1MU09@1224,1RMEI@1236,3XNRN@561,COG1123@1,COG4172@2	NA|NA|NA	P	Part of a putrescine export transport system, does not play a role in resistance to antimicrobial peptides. Stimulates K( )-uptake proteins TrkG and TrkH to import K( ), may act via ATP-binding rather than ATP hydrolysis
C1_01937	198214.SF1295	3.5e-146	524.2	Gammaproteobacteria	sapF	GO:0000166,GO:0003674,GO:0005215,GO:0005488,GO:0005524,GO:0006810,GO:0006811,GO:0006812,GO:0008144,GO:0008150,GO:0008324,GO:0008519,GO:0015075,GO:0015101,GO:0015203,GO:0015489,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0017076,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034220,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0072488,GO:0097159,GO:0097367,GO:0098655,GO:1901265,GO:1901363,GO:1902047		ko:K19230	ko01503,ko02010,map01503,map02010	M00739			ko00000,ko00001,ko00002,ko02000	3.A.1.5.5			Bacteria	1MU09@1224,1RMEI@1236,COG1123@1,COG4172@2	NA|NA|NA	P	ATPase activity
C1_01938	198214.SF1294	2.8e-60	237.7	Gammaproteobacteria	ycjD			ko:K04568					ko00000,ko01000,ko03012				Bacteria	1N0QU@1224,1S8Z3@1236,COG2852@1,COG2852@2	NA|NA|NA	S	Protein of unknown function (DUF559)
C1_01939	155864.EDL933_2400	7.1e-144	516.5	Escherichia	fabI	GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0034641,GO:0042364,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004			iECUMN_1333.ECUMN_1592	Bacteria	1MV05@1224,1RNMW@1236,3XPE3@561,COG0623@1,COG0623@2	NA|NA|NA	I	Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism and in the biotin biosynthesis
C1_01940	481805.EcolC_2338	1.2e-213	748.8	Escherichia	yciW												Bacteria	1PBP5@1224,1RN1H@1236,3XMXK@561,COG2128@1,COG2128@2,COG4950@1,COG4950@2	NA|NA|NA	S	protein conserved in bacteria
C1_01941	316407.1742100	0.0	1288.1	Escherichia	rnb	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0008859,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360,GO:1901361,GO:1901575	3.1.13.1	ko:K01147					ko00000,ko01000,ko03016				Bacteria	1P563@1224,1RP5G@1236,3XN7V@561,COG4776@1,COG4776@2	NA|NA|NA	J	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
C1_01942	316407.1742099	0.0	1299.3	Escherichia	gmr	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005525,GO:0008081,GO:0008150,GO:0010468,GO:0010608,GO:0016787,GO:0016788,GO:0017076,GO:0019001,GO:0019222,GO:0031279,GO:0031280,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0042578,GO:0043086,GO:0043167,GO:0043168,GO:0044092,GO:0050789,GO:0050790,GO:0060255,GO:0065007,GO:0065009,GO:0071111,GO:0097159,GO:0097367,GO:1901265,GO:1901363	3.1.4.52	ko:K14051,ko:K20965	ko02024,ko02026,ko05111,map02024,map02026,map05111				ko00000,ko00001,ko01000				Bacteria	1MU2C@1224,1RM8A@1236,3XPH6@561,COG5001@1,COG5001@2	NA|NA|NA	T	Part of a 2 protein system that seems to be dedicated to transcription of csgD. This protein decreases csgD transcription and thus decreases expression of adhesive curli fimbriae genes csgEFG, csgBAC ymaD and adrA (yaic). Activity of this protein is antagonized by the diguanylate cyclase YdaM. In vitro has c-di-GMP phosphodiesterase activity. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria
C1_01943	199310.c1755	1.3e-23	114.8	Escherichia	yciZ												Bacteria	1ND39@1224,1SCW0@1236,2E3CA@1,32YBK@2,3XQ4C@561	NA|NA|NA	S	Belongs to the UPF0509 family
C1_01944	155864.EDL933_2405	4.8e-134	483.8	Escherichia	yciT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141											Bacteria	1MV49@1224,1RRR5@1236,3XM3W@561,COG1349@1,COG1349@2	NA|NA|NA	K	Transcriptional regulator
C1_01945	155864.EDL933_2406	2.3e-28	131.0	Escherichia	osmB			ko:K04062					ko00000				Bacteria	1N0HV@1224,1S93Y@1236,2CMW8@1,32SFP@2,3XPYH@561	NA|NA|NA	M	Provides resistance to osmotic stress. May be important for stationary-phase survival
C1_01946	316407.1742096	3.1e-53	214.2	Escherichia	yciH	GO:0001731,GO:0002181,GO:0002183,GO:0002188,GO:0002190,GO:0002192,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0110017,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K03113	ko03013,map03013				ko00000,ko00001,ko03012				Bacteria	1MZ8T@1224,1S929@1236,3XPU0@561,COG0023@1,COG0023@2	NA|NA|NA	J	cap-independent translational initiation of linear mRNA
C1_01947	155864.EDL933_2408	1.6e-140	505.4	Escherichia	pyrF	GO:0003674,GO:0003824,GO:0004590,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000			iECO103_1326.ECO103_1444,iECSF_1327.ECSF_1264,iSFV_1184.SFV_1294,iSF_1195.SF1285,iSFxv_1172.SFxv_1457,iS_1188.S1368,ic_1306.c1750	Bacteria	1MW2C@1224,1RNJR@1236,3XPD8@561,COG0284@1,COG0284@2	NA|NA|NA	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
C1_01948	155864.EDL933_2410	2.2e-218	764.6	Escherichia	lapB	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008653,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1903509		ko:K19804					ko00000				Bacteria	1MVDP@1224,1RP29@1236,3XNQF@561,COG2956@1,COG2956@2	NA|NA|NA	G	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C1_01949	198214.SF1283	5.9e-46	189.9	Gammaproteobacteria	lapA	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008653,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0043170,GO:0044237,GO:0044238,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:1901135,GO:1903509		ko:K08992					ko00000				Bacteria	1MZGX@1224,1S9X9@1236,COG3771@1,COG3771@2	NA|NA|NA	S	Involved in the assembly of lipopolysaccharide (LPS)
C1_01950	155864.EDL933_2412	5.8e-143	513.5	Escherichia	pgpB	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008962,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009279,GO:0009987,GO:0016020,GO:0016021,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0019637,GO:0019867,GO:0030203,GO:0030312,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0034645,GO:0042546,GO:0042578,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044425,GO:0044459,GO:0044462,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0050380,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	3.1.3.27,3.1.3.4,3.1.3.81,3.6.1.27	ko:K01096,ko:K19302	ko00550,ko00564,ko01100,map00550,map00564,map01100		R02029,R05627	RC00002,RC00017	ko00000,ko00001,ko01000,ko01011			iEC042_1314.EC042_1403,iECUMN_1333.ECUMN_1580	Bacteria	1MWW4@1224,1RNSB@1236,3XPD6@561,COG0671@1,COG0671@2	NA|NA|NA	I	Catalyzes the dephosphorylation of diacylglycerol diphosphate (DGPP) to phosphatidate (PA) and the subsequent dephosphorylation of PA to diacylglycerol (DAG). Also has undecaprenyl pyrophosphate phosphatase activity, required for the biosynthesis of the lipid carrier undecaprenyl phosphate. Can also use lysophosphatidic acid (LPA) and phosphatidylglycerophosphate as substrates. The pattern of activities varies according to subcellular location, PGP phosphatase activity is higher in the cytoplasmic membrane, whereas PA and LPA phosphatase activities are higher in the outer membrane. Activity is independent of a divalent cation ion and insensitive to inhibition by N- ethylmaleimide
C1_01951	155864.EDL933_2413	2.5e-109	401.4	Escherichia	ribA	GO:0003674,GO:0003824,GO:0003933,GO:0003935,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019238,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.5.4.25	ko:K01497	ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024	M00125	R00425	RC00293,RC02504	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_437,iPC815.YPO2222,iSbBS512_1146.SbBS512_E1505,iUTI89_1310.UTI89_C1548	Bacteria	1MWZR@1224,1RMFX@1236,3XM8V@561,COG0807@1,COG0807@2	NA|NA|NA	F	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate
C1_01952	316407.1742087	0.0	1785.4	Escherichia	acnA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044262,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046459,GO:0046487,GO:0046872,GO:0046914,GO:0047456,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_436,iECOK1_1307.ECOK1_1491,iECS88_1305.ECS88_1416,iJN746.PP_2112,iUMN146_1321.UM146_10390,iUTI89_1310.UTI89_C1547	Bacteria	1MU9T@1224,1RN5I@1236,3XNZ5@561,COG1048@1,COG1048@2	NA|NA|NA	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C1_01954	469008.B21_01263	1.9e-22	110.9	Escherichia													Bacteria	1NICF@1224,1SHXE@1236,2EUTS@1,33N9B@2,3XR9P@561	NA|NA|NA		
C1_01955	155864.EDL933_2416	1.5e-16	90.9	Gammaproteobacteria	ymiA												Bacteria	1NMDD@1224,1SGH3@1236,2EM1Z@1,33ERG@2	NA|NA|NA		
C1_01956	155864.EDL933_2417	4.7e-182	643.7	Escherichia	cysB	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0097159,GO:1901363		ko:K13634,ko:K13635					ko00000,ko03000				Bacteria	1MU8N@1224,1RN7T@1236,3XMHJ@561,COG0583@1,COG0583@2	NA|NA|NA	K	This protein is a positive regulator of gene expression for the cysteine regulon
C1_01957	155864.EDL933_2418	0.0	1721.1	Escherichia	topA	GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360	5.99.1.2	ko:K03168					ko00000,ko01000,ko03032,ko03400				Bacteria	1MUFZ@1224,1RNZ2@1236,3XMWC@561,COG0550@1,COG0550@2	NA|NA|NA	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C1_01958	1440052.EAKF1_ch0161	4.4e-39	166.8	Escherichia	yciN	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Bacteria	1N8PV@1224,1S938@1236,2CK10@1,32SBA@2,3XPUN@561	NA|NA|NA	S	Protein of unknown function (DUF2498)
C1_01959	198214.SF1274	1.3e-180	639.0	Gammaproteobacteria	sohB	GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0016020,GO:0019538,GO:0043170,GO:0044238,GO:0044464,GO:0071704,GO:0071944,GO:1901564		ko:K04773,ko:K04774					ko00000,ko01000,ko01002				Bacteria	1MUXE@1224,1RNN9@1236,COG0616@1,COG0616@2	NA|NA|NA	OU	peptidase
C1_01960	198214.SF1273	9.2e-141	506.1	Gammaproteobacteria													Bacteria	1MWBC@1224,1RNNV@1236,COG1028@1,COG1028@2	NA|NA|NA	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
C1_01961	199310.c1735	1.3e-105	389.0	Escherichia	cobO	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008817,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019250,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.17	ko:K16092,ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.14.3		iAF1260.b1270,iB21_1397.B21_01256,iBWG_1329.BWG_1099,iECABU_c1320.ECABU_c15500,iECBD_1354.ECBD_2352,iECB_1328.ECB_01246,iECDH10B_1368.ECDH10B_1385,iECDH1ME8569_1439.ECDH1ME8569_1209,iECD_1391.ECD_01246,iECIAI1_1343.ECIAI1_1288,iECO111_1330.ECO111_1649,iECO26_1355.ECO26_1834,iETEC_1333.ETEC_1372,iEcDH1_1363.EcDH1_2379,iEcHS_1320.EcHS_A1379,iJO1366.b1270,iJR904.b1270,iLF82_1304.LF82_0253,iNRG857_1313.NRG857_06515,iUMNK88_1353.UMNK88_1599,iY75_1357.Y75_RS06640,iYL1228.KPN_01266,ic_1306.c1735	Bacteria	1MUN6@1224,1RMH9@1236,3XMRV@561,COG2109@1,COG2109@2	NA|NA|NA	H	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
C1_01962	155864.EDL933_2423	5.4e-161	573.5	Escherichia	rluB	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.22	ko:K06178					ko00000,ko01000,ko03009				Bacteria	1MUCE@1224,1RQU0@1236,3XPCZ@561,COG1187@1,COG1187@2	NA|NA|NA	J	Responsible for synthesis of pseudouridine from uracil- 2605 in 23S ribosomal RNA
C1_01963	155864.EDL933_2425	2.7e-114	417.9	Escherichia	yciO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.7.7.87	ko:K07566			R10463	RC00745	ko00000,ko01000,ko03009,ko03016				Bacteria	1MVPM@1224,1RNU8@1236,3XNT1@561,COG0009@1,COG0009@2	NA|NA|NA	J	Belongs to the SUA5 family
C1_01964	316407.1742058	1.7e-170	605.1	Escherichia	trpH	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004532,GO:0004534,GO:0004536,GO:0004540,GO:0005488,GO:0006139,GO:0006259,GO:0006521,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008409,GO:0009987,GO:0010565,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016796,GO:0016895,GO:0016896,GO:0019222,GO:0030145,GO:0031323,GO:0033238,GO:0034641,GO:0035312,GO:0042578,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:0090357,GO:0090501,GO:0090503,GO:0097657,GO:0140097,GO:0140098,GO:1901360	3.1.3.97	ko:K07053			R00188,R11188	RC00078	ko00000,ko01000				Bacteria	1MWIH@1224,1RNCG@1236,3XNVX@561,COG0613@1,COG0613@2	NA|NA|NA	S	Efficiently catalyzes the hydrolysis of the 3'-phosphate from 3',5'-bis-phosphonucleotides as well as the successive hydrolysis of 5'-phosphomononucleotides from the 5'-end of short pieces of RNA and DNA, with no specificity toward the identity of the nucleotide base. Is more efficient at hydrolyzing RNA oligonucleotides than DNA oligonucleotides. This enzyme can also hydrolyze annealed DNA duplexes, albeit at a catalytic efficiency approximately 10-fold lower than that of the corresponding single- stranded oligonucleotides
C1_01965	155864.EDL933_2427	8.7e-295	1018.8	Escherichia	trpE	GO:0000162,GO:0003674,GO:0003824,GO:0004049,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000			iG2583_1286.G2583_1603,iIT341.HP1282	Bacteria	1MVBJ@1224,1RMSE@1236,3XP2S@561,COG0147@1,COG0147@2	NA|NA|NA	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C1_01966	316407.1742056	1.6e-299	1034.6	Escherichia	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0004048,GO:0004049,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006520,GO:0006568,GO:0006575,GO:0006576,GO:0006586,GO:0006725,GO:0006732,GO:0006753,GO:0006760,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009308,GO:0009309,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0016769,GO:0016829,GO:0016830,GO:0016833,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042398,GO:0042401,GO:0042430,GO:0042435,GO:0042451,GO:0042455,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046219,GO:0046390,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046820,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901657,GO:1901659,GO:1902494	2.4.2.18,2.6.1.85,4.1.3.27	ko:K00766,ko:K01658,ko:K01664,ko:K13497	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01073,R01716	RC00010,RC00440,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000			iIT341.HP1281,iSBO_1134.SBO_1803,iSbBS512_1146.SbBS512_E1488,iYL1228.KPN_01256	Bacteria	1MUPV@1224,1RNXV@1236,3XMT6@561,COG0512@1,COG0512@2,COG0547@1,COG0547@2	NA|NA|NA	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C1_01967	469008.B21_01246	1.3e-254	885.2	Escherichia	trpF	GO:0000162,GO:0003674,GO:0003824,GO:0004425,GO:0004640,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.1.1.48,4.2.1.160,4.2.1.20,5.3.1.24	ko:K01609,ko:K01696,ko:K01817,ko:K13498,ko:K22100	ko00260,ko00400,ko00790,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map00790,map01100,map01110,map01130,map01230	M00023,M00840	R00674,R02340,R02722,R03508,R03509,R11072	RC00209,RC00210,RC00700,RC00701,RC00944,RC00945,RC02868,RC03343	ko00000,ko00001,ko00002,ko01000			iJN678.trpF,iPC815.YPO2205,iSBO_1134.SBO_1804,iSDY_1059.SDY_1330	Bacteria	1MW5K@1224,1RNYH@1236,3XNN3@561,COG0134@1,COG0134@2,COG0135@1,COG0135@2	NA|NA|NA	E	Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain
C1_01968	198214.SF1264	4.1e-228	797.0	Gammaproteobacteria	trpB	GO:0000162,GO:0003674,GO:0003824,GO:0004834,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0019842,GO:0030170,GO:0034641,GO:0036094,GO:0042401,GO:0042430,GO:0042435,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000			iECSF_1327.ECSF_1239,iPC815.YPO2204	Bacteria	1MUS8@1224,1RP4D@1236,COG0133@1,COG0133@2	NA|NA|NA	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
C1_01969	198214.SF1263	1.2e-146	525.8	Gammaproteobacteria	trpA	GO:0000162,GO:0003674,GO:0003824,GO:0004834,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000			iECED1_1282.ECED1_1467,iECP_1309.ECP_1308	Bacteria	1MXJV@1224,1RMGN@1236,COG0159@1,COG0159@2	NA|NA|NA	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
C1_01970	155864.EDL933_2433	8.2e-08	62.4	Gammaproteobacteria	yciG	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588		ko:K06884					ko00000				Bacteria	1N767@1224,1SCA5@1236,COG3729@1,COG3729@2	NA|NA|NA	S	Stress-induced protein
C1_01971	155864.EDL933_2434	5.4e-81	307.0	Escherichia	yciF	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716											Bacteria	1REKN@1224,1S45E@1236,3XPTQ@561,COG3685@1,COG3685@2	NA|NA|NA	S	cellular response to DNA damage stimulus
C1_01972	199310.c1723	1.8e-87	328.6	Escherichia	yciE	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716											Bacteria	1R4MJ@1224,1RRW4@1236,3XPRR@561,COG3685@1,COG3685@2	NA|NA|NA	S	cellular response to DNA damage stimulus
C1_01973	198214.SF1259	6.4e-119	433.3	Gammaproteobacteria	ompW	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944		ko:K07275					ko00000				Bacteria	1NUZJ@1224,1RRRC@1236,COG3047@1,COG3047@2	NA|NA|NA	M	outer membrane protein W
C1_01974	469008.B21_01239	6.3e-118	430.3	Escherichia	yciC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1PYD0@1224,1RQC3@1236,28JC8@1,2Z96Y@2,3XM32@561	NA|NA|NA	S	Uncharacterised protein family (UPF0259)
C1_01975	155864.EDL933_1958	4.2e-87	327.4	Escherichia	ispZ	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K06190					ko00000				Bacteria	1NWIZ@1224,1RQAB@1236,3XM6E@561,COG2917@1,COG2917@2	NA|NA|NA	D	probably involved in intracellular septation
C1_01976	198214.SF1256	2.4e-68	264.6	Gammaproteobacteria	yciA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016289,GO:0016787,GO:0016788,GO:0016790,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0047617,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564		ko:K10806	ko01040,map01040				ko00000,ko00001,ko01000,ko01004				Bacteria	1MZAZ@1224,1SA9N@1236,COG1607@1,COG1607@2	NA|NA|NA	I	acyl-CoA thioester hydrolase
C1_01977	198214.SF1255	3.6e-105	387.9	Gammaproteobacteria	tonB	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0007154,GO:0007165,GO:0008150,GO:0009897,GO:0009986,GO:0009987,GO:0015688,GO:0015833,GO:0015889,GO:0015891,GO:0015893,GO:0016020,GO:0016021,GO:0016032,GO:0019058,GO:0019062,GO:0019904,GO:0022610,GO:0023052,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0031992,GO:0032991,GO:0042221,GO:0042493,GO:0042597,GO:0042886,GO:0042891,GO:0042914,GO:0043213,GO:0044403,GO:0044406,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0044650,GO:0046813,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051180,GO:0051181,GO:0051234,GO:0051704,GO:0051716,GO:0060089,GO:0065007,GO:0071575,GO:0071702,GO:0071705,GO:0071944,GO:0098002,GO:0098552,GO:0098670,GO:0098796,GO:0098797,GO:1901678		ko:K03832					ko00000,ko02000	2.C.1.1		iAPECO1_1312.APECO1_368,iEC55989_1330.EC55989_1350,iECABU_c1320.ECABU_c15340,iECNA114_1301.ECNA114_1423,iECO103_1326.ECO103_1353,iECP_1309.ECP_1300,iECSF_1327.ECSF_1233,iEcE24377_1341.EcE24377A_1410	Bacteria	1MXBE@1224,1RMI4@1236,COG0810@1,COG0810@2	NA|NA|NA	U	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
C1_01978	218491.ECA2508	1.3e-53	217.6	Pectobacterium	ybcK												Bacteria	1MTV6@122277,1N6DV@1224,1RYWS@1236,COG1961@1,COG1961@2	NA|NA|NA	L	Recombinase zinc beta ribbon domain
C1_01979	1283336.Q6KGH3_BPFO1	5.2e-70	271.2	Myoviridae													Viruses	4QH6I@10239,4QI9W@10662,4QRZC@28883,4QZ2G@35237	NA|NA|NA		
C1_01980	502347.ESCAB7627_4149	5.5e-279	966.8	Gammaproteobacteria													Bacteria	1RM44@1224,1SFIQ@1236,COG3941@1,COG3941@2	NA|NA|NA	D	tape measure
C1_01988	1121468.AUBR01000099_gene3089	1.8e-10	73.2	Clostridia													Bacteria	1V43D@1239,24KG0@186801,2CDFK@1,2Z8BH@2	NA|NA|NA	H	DNA N-6-adenine-methyltransferase
C1_01989	1051646.VITU9109_07329	3.5e-60	238.0	Vibrionales													Bacteria	1RA0V@1224,1RPSK@1236,1XUTZ@135623,COG1961@1,COG1961@2	NA|NA|NA	L	Resolvase, N terminal domain
C1_01990	155864.EDL933_1955	2.3e-47	194.5	Escherichia	yciI	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K05527,ko:K09780					ko00000,ko03000				Bacteria	1MZ9Z@1224,1S8UC@1236,3XPWC@561,COG2350@1,COG2350@2	NA|NA|NA	S	YCII-related domain
C1_01991	469008.B21_01234	2.6e-225	787.7	Escherichia	kch	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015318,GO:0015672,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042802,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055085,GO:0065003,GO:0071804,GO:0071805,GO:0071840,GO:0071944,GO:0098655,GO:0098660,GO:0098662		ko:K10716					ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6		iEC042_1314.EC042_1304,iECUMN_1333.ECUMN_1549	Bacteria	1R3QQ@1224,1RPFS@1236,3XNGG@561,COG1226@1,COG1226@2	NA|NA|NA	P	Potassium channel
C1_01992	199310.c1713	3.3e-280	970.3	Escherichia	cls	GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008808,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0019637,GO:0030572,GO:0032048,GO:0032049,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576	2.7.8.8	ko:K00998,ko:K06131,ko:K06132	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800,R07390,R11062	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000			iECED1_1282.ECED1_0754,iECH74115_1262.ECH74115_3822,iECSP_1301.ECSP_3532,iSDY_1059.SDY_1307	Bacteria	1MWUW@1224,1RPQG@1236,3XMEC@561,COG1502@1,COG1502@2	NA|NA|NA	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1_01993	155864.EDL933_1952	6.1e-57	226.5	Escherichia	yciU			ko:K09901					ko00000				Bacteria	1RE1F@1224,1S43E@1236,3XPP5@561,COG3099@1,COG3099@2	NA|NA|NA	S	Belongs to the UPF0263 family
C1_01994	155864.EDL933_1951	3.7e-190	670.6	Escherichia	oppF	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K02032,ko:K10823,ko:K12372	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00324,M00439			ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25		iAPECO1_1312.APECO1_362,iECH74115_1262.ECH74115_2095,iECOK1_1307.ECOK1_1402,iECS88_1305.ECS88_1315,iECSP_1301.ECSP_1968,iECs_1301.ECs2087,iSF_1195.SF3575,iSFxv_1172.SFxv_3897,iS_1188.S4195,iUMN146_1321.UM146_10835,iUTI89_1310.UTI89_C1445,iZ_1308.Z2227	Bacteria	1NU4K@1224,1SKPD@1236,3XP3N@561,COG4608@1,COG4608@2	NA|NA|NA	P	Belongs to the ABC transporter superfamily
C1_01995	469008.B21_01230	7.4e-186	656.4	Escherichia	oppD	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	3.6.3.24	ko:K02031,ko:K02032,ko:K02034,ko:K12371,ko:K15583,ko:K15587	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00324,M00439,M00440			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25		iECED1_1282.ECED1_1398,iECIAI1_1343.ECIAI1_1494,iECIAI39_1322.ECIAI39_3960,iEcSMS35_1347.EcSMS35_3763,iLF82_1304.LF82_1573,iSBO_1134.SBO_1821	Bacteria	1R4KB@1224,1SMBI@1236,3XMHZ@561,COG0444@1,COG0444@2	NA|NA|NA	P	Belongs to the ABC transporter superfamily
C1_01996	316407.1742034	1.6e-147	528.9	Escherichia	oppC	GO:0000041,GO:0003674,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015099,GO:0015318,GO:0015675,GO:0016020,GO:0016021,GO:0016151,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0035444,GO:0043167,GO:0043169,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0046914,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098655,GO:0098660,GO:0098662		ko:K02034,ko:K12370,ko:K13891,ko:K15582,ko:K15586	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00324,M00348,M00439,M00440			ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.11,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25		iAF1260.b1245,iAF1260.b3542,iAPECO1_1312.APECO1_2906,iB21_1397.B21_01229,iB21_1397.B21_03344,iBWG_1329.BWG_3231,iE2348C_1286.E2348C_3790,iEC042_1314.EC042_3848,iEC55989_1330.EC55989_1342,iEC55989_1330.EC55989_3993,iECABU_c1320.ECABU_c08730,iECABU_c1320.ECABU_c39840,iECBD_1354.ECBD_0194,iECBD_1354.ECBD_2377,iECB_1328.ECB_01219,iECB_1328.ECB_03393,iECDH10B_1368.ECDH10B_1307,iECDH10B_1368.ECDH10B_3721,iECDH1ME8569_1439.ECDH1ME8569_1185,iECDH1ME8569_1439.ECDH1ME8569_3422,iECD_1391.ECD_01219,iECD_1391.ECD_03393,iECED1_1282.ECED1_4221,iECH74115_1262.ECH74115_4910,iECIAI1_1343.ECIAI1_1264,iECIAI1_1343.ECIAI1_3700,iECIAI39_1322.ECIAI39_4051,iECNA114_1301.ECNA114_3693,iECO103_1326.ECO103_1345,iECO103_1326.ECO103_4274,iECO111_1330.ECO111_1572,iECO111_1330.ECO111_4358,iECO26_1355.ECO26_1756,iECO26_1355.ECO26_4636,iECOK1_1307.ECOK1_3988,iECP_1309.ECP_0846,iECP_1309.ECP_3643,iECS88_1305.ECS88_3962,iECSE_1348.ECSE_1293,iECSE_1348.ECSE_3815,iECSF_1327.ECSF_3376,iECSP_1301.ECSP_1637,iECSP_1301.ECSP_4533,iECUMN_1333.ECUMN_1542,iECUMN_1333.ECUMN_4052,iECW_1372.ECW_m1337,iECW_1372.ECW_m3808,iECs_1301.ECs1745,iECs_1301.ECs4422,iEKO11_1354.EKO11_0191,iEKO11_1354.EKO11_2607,iETEC_1333.ETEC_1347,iETEC_1333.ETEC_3787,iEcDH1_1363.EcDH1_0170,iEcDH1_1363.EcDH1_2403,iEcE24377_1341.EcE24377A_1393,iEcE24377_1341.EcE24377A_4034,iEcHS_1320.EcHS_A1354,iEcHS_1320.EcHS_A3741,iEcSMS35_1347.EcSMS35_3861,iEcolC_1368.EcolC_0173,iEcolC_1368.EcolC_2383,iG2583_1286.G2583_1517,iG2583_1286.G2583_4279,iJO1366.b1245,iJO1366.b3542,iLF82_1304.LF82_0517,iNRG857_1313.NRG857_17605,iSSON_1240.SSON_1935,iSbBS512_1146.SbBS512_E3843,iUMN146_1321.UM146_17880,iUMNK88_1353.UMNK88_1565,iUMNK88_1353.UMNK88_4323,iUTI89_1310.UTI89_C4080,iWFL_1372.ECW_m1337,iWFL_1372.ECW_m3808,iY75_1357.Y75_RS06515,iY75_1357.Y75_RS19465,iZ_1308.Z2021,iZ_1308.Z4959,ic_1306.c0917,ic_1306.c4357	Bacteria	1MU26@1224,1RND6@1236,3XMVD@561,COG1173@1,COG1173@2	NA|NA|NA	EP	Oligopeptide transport system permease protein OppC
C1_01997	155864.EDL933_1948	1.1e-156	559.3	Escherichia	oppB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944		ko:K02033,ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439			ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25			Bacteria	1MU8Z@1224,1RNJ1@1236,3XNE6@561,COG0601@1,COG0601@2	NA|NA|NA	EP	probably responsible for the translocation of the substrate across the membrane
C1_01998	155864.EDL933_1947	0.0	1140.2	Escherichia	oppA	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006810,GO:0006857,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0015833,GO:0030288,GO:0030313,GO:0031975,GO:0033218,GO:0042277,GO:0042597,GO:0042886,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0061077,GO:0071702,GO:0071705,GO:1900750		ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439			ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25		iECABU_c1320.ECABU_c15240,iECNA114_1301.ECNA114_1414,iECSF_1327.ECSF_1224,iNRG857_1313.NRG857_06385,iUMNK88_1353.UMNK88_1667	Bacteria	1P91R@1224,1RN57@1236,3XMGQ@561,COG4166@1,COG4166@2	NA|NA|NA	E	periplasmic oligopeptide-binding protein
C1_02001	316407.85674882	3.6e-109	401.0	Escherichia	ychE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K05595					ko00000,ko02000	2.A.95.1			Bacteria	1MX5T@1224,1RPZ3@1236,3XPFF@561,COG2095@1,COG2095@2	NA|NA|NA	U	Membrane
C1_02002	155864.EDL933_1943	0.0	1733.8	Escherichia	adhE	GO:0003674,GO:0003824,GO:0004022,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006067,GO:0006115,GO:0008150,GO:0008152,GO:0008774,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0016620,GO:0016903,GO:0016999,GO:0017000,GO:0017144,GO:0034308,GO:0034309,GO:0042802,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0055114,GO:0071704,GO:1901576,GO:1901615,GO:1901617	1.1.1.1,1.2.1.10	ko:K04072	ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220		R00228,R00623,R00754,R01172,R04880,R05233,R05234,R06917,R06927	RC00004,RC00050,RC00088,RC00099,RC00116,RC00184,RC00649,RC01195	ko00000,ko00001,ko01000			iEcE24377_1341.EcE24377A_1389,iYL1228.KPN_02199	Bacteria	1MVPH@1224,1RNBH@1236,3XMER@561,COG1012@1,COG1012@2,COG1454@1,COG1454@2	NA|NA|NA	C	This enzyme has three activities ADH, ACDH, and PFL- deactivase. In aerobic conditions it acts as a hydrogen peroxide scavenger. The PFL deactivase activity catalyzes the quenching of the pyruvate-formate-lyase catalyst in an iron, NAD, and CoA dependent reaction
C1_02003	637910.ROD_02711	2.2e-27	127.5	Gammaproteobacteria	insG			ko:K07495					ko00000				Bacteria	1MVRM@1224,1RRFT@1236,COG3385@1,COG3385@2	NA|NA|NA	L	COG3385 FOG Transposase and inactivated derivatives
C1_02004	637910.ROD_02711	1.4e-72	279.3	Gammaproteobacteria	insG			ko:K07495					ko00000				Bacteria	1MVRM@1224,1RRFT@1236,COG3385@1,COG3385@2	NA|NA|NA	L	COG3385 FOG Transposase and inactivated derivatives
C1_02005	316407.1651638	8.6e-113	412.9	Escherichia	tdk	GO:0003674,GO:0003824,GO:0004797,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006259,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009120,GO:0009123,GO:0009124,GO:0009157,GO:0009162,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019136,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046104,GO:0046125,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0090304,GO:0090407,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.1.21	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100		R01567,R02099,R08233	RC00002,RC00017	ko00000,ko00001,ko01000			iAF1260.b1238,iBWG_1329.BWG_1065,iECDH10B_1368.ECDH10B_1298,iECDH1ME8569_1439.ECDH1ME8569_1176,iEcDH1_1363.EcDH1_2411,iJO1366.b1238,iJR904.b1238,iPC815.YPO2176,iY75_1357.Y75_RS06470	Bacteria	1NJR4@1224,1RPCK@1236,3XPH5@561,COG1435@1,COG1435@2	NA|NA|NA	F	thymidine kinase
C1_02006	155864.EDL933_1940	2.5e-63	248.1	Escherichia	hns	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003681,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0042802,GO:0043565,GO:0043900,GO:0043901,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1900190,GO:1900191,GO:1900231,GO:1900232,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K03746,ko:K11685,ko:K20552	ko02020,ko02024,map02020,map02024				ko00000,ko00001,ko03036,ko03400				Bacteria	1R9YM@1224,1S24H@1236,3XPMF@561,COG2916@1,COG2916@2	NA|NA|NA	K	A DNA-binding protein implicated in transcriptional repression and chromosome organization and compaction. Binds nucleation sites in AT-rich DNA and bridges them, forming higher- order nucleoprotein complexes and condensing the chromosome. As many horizontally transferred genes are AT-rich, it plays a central role in silencing foreign genes. A subset of genes are repressed by H-NS in association with other proteins (By similarity)
C1_02007	155864.EDL933_1939	7.3e-169	599.7	Escherichia	galU	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0003983,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005996,GO:0006011,GO:0006012,GO:0006073,GO:0006139,GO:0006629,GO:0006725,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009056,GO:0009058,GO:0009059,GO:0009103,GO:0009225,GO:0009242,GO:0009244,GO:0009250,GO:0009311,GO:0009312,GO:0009987,GO:0016043,GO:0016051,GO:0016052,GO:0016740,GO:0016772,GO:0016779,GO:0019318,GO:0019320,GO:0019388,GO:0022607,GO:0033499,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043933,GO:0044042,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046377,GO:0046401,GO:0046483,GO:0046872,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051748,GO:0055086,GO:0065003,GO:0070569,GO:0071704,GO:0071840,GO:1900725,GO:1900727,GO:1901135,GO:1901137,GO:1901360,GO:1901575,GO:1901576,GO:1903509	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000			iECIAI39_1322.ECIAI39_1571	Bacteria	1MV5F@1224,1RNDX@1236,3XNPY@561,COG1210@1,COG1210@2	NA|NA|NA	M	May play a role in stationary phase survival
C1_02008	155864.EDL933_1938	1.6e-188	665.2	Escherichia													Bacteria	1R3UE@1224,1RRJX@1236,3XP2A@561,COG0745@1,COG0745@2	NA|NA|NA	KT	Regulates the turnover of the sigma S factor (RpoS) by promoting its proteolysis in exponentially growing cells. Acts by binding and delivering RpoS to the ClpXP protease. RssB is not co- degraded with RpoS, but is released from the complex and can initiate a new cycle of RpoS recognition and degradation
C1_02009	155864.EDL933_1937	7.6e-177	626.3	Escherichia	rssA	GO:0003674,GO:0003824,GO:0016787		ko:K07001					ko00000				Bacteria	1MUM9@1224,1RRA1@1236,3XQ8D@561,COG1752@1,COG1752@2	NA|NA|NA	S	phosphatidylcholine metabolic process
C1_02010	316407.4062802	4.5e-90	337.0	Escherichia	ychJ			ko:K09858					ko00000				Bacteria	1MZZK@1224,1S9FV@1236,3XPSS@561,COG3012@1,COG3012@2	NA|NA|NA	S	Belongs to the UPF0225 family
C1_02011	198214.SF1232	8.3e-159	566.2	Gammaproteobacteria	purU	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006753,GO:0006760,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008864,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009256,GO:0009257,GO:0009259,GO:0009260,GO:0009396,GO:0009987,GO:0016053,GO:0016787,GO:0016810,GO:0016811,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0034641,GO:0034654,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.72,3.5.1.10	ko:K00974,ko:K01433	ko00630,ko00670,ko03013,map00630,map00670,map03013		R00944,R09382,R09383,R09384,R09386	RC00026,RC00078,RC00111	ko00000,ko00001,ko01000,ko03016			iSDY_1059.SDY_1284	Bacteria	1MVCF@1224,1RN6Q@1236,COG0788@1,COG0788@2	NA|NA|NA	F	Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)
C1_02014	155864.EDL933_1934	7e-124	449.9	Escherichia	narI	GO:0001666,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006950,GO:0008150,GO:0008152,GO:0008940,GO:0009055,GO:0009061,GO:0009325,GO:0009628,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016661,GO:0019645,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0036293,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044799,GO:0045333,GO:0046906,GO:0048037,GO:0050896,GO:0055114,GO:0070469,GO:0070470,GO:0070482,GO:0071944,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901363,GO:1902494,GO:1990204	1.7.5.1	ko:K00370,ko:K00374,ko:K02575	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00615,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.1.8,5.A.3.1		iEC042_1314.EC042_1594,iECUMN_1333.ECUMN_1718,iNJ661.Rv1164,iSF_1195.SF1230	Bacteria	1MXGZ@1224,1RPTD@1236,3XM94@561,COG2181@1,COG2181@2	NA|NA|NA	C	The nitrate reductase enzyme complex allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The gamma chain is a membrane-embedded heme-iron unit resembling cytochrome b, which transfers electrons from quinones to the beta subunit
C1_02015	469008.B21_01214	1.2e-126	459.1	Escherichia	narJ	GO:0001666,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009987,GO:0016043,GO:0016530,GO:0022607,GO:0034622,GO:0036293,GO:0042126,GO:0042128,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0050896,GO:0051131,GO:0065003,GO:0070482,GO:0071704,GO:0071840,GO:0071941,GO:0140104,GO:2001057	1.7.5.1	ko:K00370,ko:K00373,ko:K17052	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.1,5.A.3.8		iE2348C_1286.E2348C_1350,iECABU_c1320.ECABU_c15020,iECIAI1_1343.ECIAI1_1469,iECO103_1326.ECO103_1331,iECO111_1330.ECO111_1557,iECW_1372.ECW_m1594,iEKO11_1354.EKO11_2354,iLF82_1304.LF82_1462,iNRG857_1313.NRG857_06280,iSSON_1240.SSON_1659,iWFL_1372.ECW_m1594,iYO844.BSU37260,ic_1306.c1687	Bacteria	1MY4E@1224,1RQ23@1236,3XMJW@561,COG2180@1,COG2180@2	NA|NA|NA	C	Chaperone required for proper molybdenum cofactor insertion and final assembly of the membrane-bound respiratory nitrate reductase 1. Required for the insertion of the molybdenum into the apo-NarG subunit, maybe by keeping NarG in an appropriate competent-open conformation for the molybdenum cofactor insertion to occur. NarJ maintains the apoNarGH complex in a soluble state. Upon insertion of the molybdenum cofactor, NarJ seems to dissociate from the activated soluble NarGH complex, before its association with the NarI subunit on the membrane
C1_02016	1440052.EAKF1_ch0214c	2.1e-311	1074.7	Escherichia	narH	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006091,GO:0006807,GO:0008150,GO:0008152,GO:0008940,GO:0009055,GO:0009061,GO:0009325,GO:0009898,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016661,GO:0022900,GO:0031224,GO:0031226,GO:0031235,GO:0032991,GO:0042126,GO:0043436,GO:0044237,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0044799,GO:0045333,GO:0048037,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204,GO:2001057	1.7.5.1	ko:K00371	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1		iAF987.Gmet_1021,iEcE24377_1341.EcE24377A_1376,iEcolC_1368.EcolC_2189	Bacteria	1MW9Q@1224,1RNMJ@1236,3XMWG@561,COG1140@1,COG1140@2	NA|NA|NA	C	The nitrate reductase enzyme complex allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The beta chain is an electron transfer unit containing four cysteine clusters involved in the formation of iron-sulfur centers. Electrons are transferred from the gamma chain to the molybdenum cofactor of the alpha subunit
C1_02017	155864.EDL933_1931	0.0	2597.0	Escherichia	narG	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006091,GO:0006807,GO:0008150,GO:0008152,GO:0008940,GO:0009055,GO:0009061,GO:0009325,GO:0009898,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016661,GO:0022900,GO:0031224,GO:0031226,GO:0031235,GO:0032991,GO:0042126,GO:0043436,GO:0043546,GO:0044237,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0044799,GO:0045333,GO:0048037,GO:0050662,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0097159,GO:0098552,GO:0098562,GO:0098796,GO:0098797,GO:0098803,GO:1901363,GO:1902494,GO:1990204,GO:2001057	1.7.5.1	ko:K00370,ko:K17050	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.1,5.A.3.8		iSBO_1134.SBO_1842,iUMN146_1321.UM146_09685	Bacteria	1MW9S@1224,1RQ27@1236,3XPE4@561,COG5013@1,COG5013@2	NA|NA|NA	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C1_02018	316407.1651617	1.6e-260	904.8	Escherichia	narK	GO:0003674,GO:0005215,GO:0005452,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656		ko:K02575	ko00910,map00910	M00615			ko00000,ko00001,ko00002,ko02000	2.A.1.8		iEcolC_1368.EcolC_2187,iUTI89_1310.UTI89_C1420	Bacteria	1MU27@1224,1RMUK@1236,3XPED@561,COG2223@1,COG2223@2	NA|NA|NA	P	Catalyzes nitrate uptake, nitrite uptake and nitrite export across the cytoplasmic membrane. Functions as a nitrate nitrite exchanger, and protons are probably not co- transported with the substrate
C1_02020	155864.EDL933_1928	0.0	1154.4	Escherichia	narX	GO:0000155,GO:0000160,GO:0001101,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010167,GO:0016020,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0033554,GO:0035556,GO:0036211,GO:0042221,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070887,GO:0071229,GO:0071241,GO:0071249,GO:0071250,GO:0071704,GO:0071944,GO:0080033,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170	2.7.13.3	ko:K07673,ko:K07674,ko:K07678	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	M00471,M00472,M00475			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	1MWZT@1224,1RNPP@1236,3XMF0@561,COG3850@1,COG3850@2	NA|NA|NA	T	Acts as a sensor for nitrate nitrite and transduces signal of nitrate availability to the NarL protein and of both nitrate nitrite to the NarP protein. NarX probably activates NarL and NarP by phosphorylation in the presence of nitrate. NarX also plays a negative role in controlling NarL activity, probably through dephosphorylation in the absence of nitrate
C1_02021	155864.EDL933_1927	1.2e-112	412.5	Escherichia	narL	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0062012,GO:0065007,GO:0080090,GO:0090352,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903314,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K07684,ko:K07685	ko02020,map02020	M00471,M00472			ko00000,ko00001,ko00002,ko02022				Bacteria	1NQH7@1224,1RNXI@1236,3XM5F@561,COG2197@1,COG2197@2	NA|NA|NA	K	This protein activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate nitrite induction signal transmitted by either the NarX or NarQ proteins
C1_02022	155864.EDL933_1926	7.1e-272	942.6	Escherichia	ychO	GO:0005575,GO:0005623,GO:0008150,GO:0009279,GO:0009405,GO:0016020,GO:0019867,GO:0030260,GO:0030312,GO:0030313,GO:0031975,GO:0044403,GO:0044409,GO:0044419,GO:0044462,GO:0044464,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0071944	3.2.1.14	ko:K01183	ko00520,ko01100,map00520,map01100		R01206,R02334	RC00467	ko00000,ko00001,ko01000		GH18		Bacteria	1QU9Z@1224,1T1R3@1236,3XN7F@561,COG4932@1,COG4932@2	NA|NA|NA	M	entry into host
C1_02023	155864.EDL933_1925	2.7e-58	231.1	Escherichia	ychN	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0034214,GO:0042802,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0051259,GO:0065003,GO:0071840		ko:K06039					ko00000				Bacteria	1RDFR@1224,1S3RB@1236,3XPQV@561,COG1553@1,COG1553@2	NA|NA|NA	P	protein hexamerization
C1_02024	198214.SF1221	3.4e-137	494.2	Gammaproteobacteria	chaC	GO:0001539,GO:0003674,GO:0003824,GO:0003839,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006518,GO:0006575,GO:0006749,GO:0006751,GO:0006790,GO:0006807,GO:0006928,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0034641,GO:0040011,GO:0042219,GO:0043171,GO:0043603,GO:0044237,GO:0044248,GO:0044273,GO:0044424,GO:0044464,GO:0048870,GO:0051179,GO:0051186,GO:0051187,GO:0051674,GO:0071704,GO:0071973,GO:0097588,GO:1901564,GO:1901565,GO:1901575		ko:K07232					ko00000				Bacteria	1QA7D@1224,1S2MT@1236,COG3703@1,COG3703@2	NA|NA|NA	P	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
C1_02025	155864.EDL933_1923	1.4e-36	158.3	Escherichia	chaB			ko:K06197					ko00000				Bacteria	1N93H@1224,1S94E@1236,3XPYK@561,COG4572@1,COG4572@2	NA|NA|NA	K	Might be a regulator of the sodium-potassium proton antiporter ChaA
C1_02026	469008.B21_01204	5.3e-190	670.2	Escherichia	chaA	GO:0003674,GO:0005215,GO:0005451,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006814,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015079,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015386,GO:0015491,GO:0015672,GO:0016020,GO:0016021,GO:0022804,GO:0022821,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0035725,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0099516,GO:1902600		ko:K07300					ko00000,ko02000	2.A.19		iB21_1397.B21_01204,iEC55989_1330.EC55989_1314,iECBD_1354.ECBD_2403,iECB_1328.ECB_01194,iECD_1391.ECD_01194,iECIAI1_1343.ECIAI1_1238,iECO103_1326.ECO103_1321,iECO111_1330.ECO111_1548,iECO26_1355.ECO26_1732,iECSE_1348.ECSE_1269,iECW_1372.ECW_m1308,iETEC_1333.ETEC_1322,iEcE24377_1341.EcE24377A_1366,iEcHS_1320.EcHS_A1324,iEcolC_1368.EcolC_2407,iSSON_1240.SSON_1961,iSbBS512_1146.SbBS512_E1383,iUMNK88_1353.UMNK88_1535,iWFL_1372.ECW_m1308	Bacteria	1MWD8@1224,1RME3@1236,3XM80@561,COG0387@1,COG0387@2	NA|NA|NA	P	proton antiporter
C1_02027	155864.EDL933_1921	4.3e-12	75.9	Escherichia				ko:K18862					ko00000,ko02048				Bacteria	1QIT0@1224,1TGNC@1236,2AWZ3@1,31NWV@2,3XRD7@561	NA|NA|NA	S	Toxin Ldr, type I toxin-antitoxin system
C1_02028	155864.EDL933_1920	4.3e-12	75.9	Escherichia													Bacteria	1QIT0@1224,1TGNC@1236,2AWZ3@1,31NWV@2,3XRD7@561	NA|NA|NA	S	Toxin Ldr, type I toxin-antitoxin system
C1_02029	155864.EDL933_1920	1.5e-12	77.4	Escherichia													Bacteria	1QIT0@1224,1TGNC@1236,2AWZ3@1,31NWV@2,3XRD7@561	NA|NA|NA	S	Toxin Ldr, type I toxin-antitoxin system
C1_02030	198214.SF1218	1.2e-157	562.4	Gammaproteobacteria	kdsA	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005996,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008676,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016043,GO:0016051,GO:0016053,GO:0016740,GO:0016765,GO:0019294,GO:0019752,GO:0022607,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046394,GO:0046400,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005				Bacteria	1MV91@1224,1RMGQ@1236,COG2877@1,COG2877@2	NA|NA|NA	M	Belongs to the KdsA family
C1_02031	155864.EDL933_1918	4.7e-151	540.4	Escherichia	ychA												Bacteria	1MVJQ@1224,1RQ7V@1236,3XP28@561,COG2912@1,COG2912@2	NA|NA|NA	S	Transglutaminase-like superfamily
C1_02032	198214.SF1216	4e-63	247.3	Gammaproteobacteria	sirB2	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1MZN6@1224,1S5WP@1236,COG3094@1,COG3094@2	NA|NA|NA	S	Invasion gene expression up-regulator SirB
C1_02033	198214.SF1215	7.7e-157	559.7	Gammaproteobacteria	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006464,GO:0006479,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0010468,GO:0016043,GO:0016740,GO:0016741,GO:0018364,GO:0019222,GO:0019538,GO:0022411,GO:0032259,GO:0032984,GO:0034641,GO:0034645,GO:0036009,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043414,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0140096,GO:1901564,GO:1901566,GO:1901576	2.1.1.297,2.1.1.298	ko:K02493,ko:K02835,ko:K07320			R10806	RC00003,RC03279	ko00000,ko01000,ko03009,ko03012				Bacteria	1MXCQ@1224,1RNGK@1236,COG2890@1,COG2890@2	NA|NA|NA	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
C1_02034	155864.EDL933_1915	4.4e-197	693.7	Escherichia	prfA	GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576		ko:K02835,ko:K15034					ko00000,ko03012				Bacteria	1MV28@1224,1RM7Q@1236,3XN9G@561,COG0216@1,COG0216@2	NA|NA|NA	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C1_02035	198214.SF1213	5.3e-226	790.0	Gammaproteobacteria	hemA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006082,GO:0006520,GO:0006536,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008883,GO:0009058,GO:0009064,GO:0009288,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0019353,GO:0019438,GO:0019752,GO:0033013,GO:0033014,GO:0033526,GO:0034641,GO:0042168,GO:0042440,GO:0042597,GO:0042802,GO:0042995,GO:0043226,GO:0043228,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0055040,GO:0055114,GO:0071704,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	1.2.1.70	ko:K02407,ko:K02492	ko00860,ko01100,ko01110,ko01120,ko02040,map00860,map01100,map01110,map01120,map02040	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000,ko02035			iECNA114_1301.ECNA114_1375,iECSF_1327.ECSF_1186,iSB619.SA_RS08420,iUTI89_1310.UTI89_C1404	Bacteria	1MU41@1224,1RNQ8@1236,COG0373@1,COG0373@2	NA|NA|NA	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C1_02036	155864.EDL933_1913	2e-117	428.3	Escherichia	lolB	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006807,GO:0008104,GO:0008150,GO:0008152,GO:0008289,GO:0009279,GO:0010876,GO:0016020,GO:0019538,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0033218,GO:0034613,GO:0042157,GO:0042277,GO:0043170,GO:0044238,GO:0044462,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0051668,GO:0070727,GO:0071704,GO:0071723,GO:0071944,GO:0072657,GO:1901564		ko:K02494					ko00000				Bacteria	1N02T@1224,1S91E@1236,3XNXQ@561,COG3017@1,COG3017@2	NA|NA|NA	M	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C1_02037	198214.SF1211	4e-161	573.9	Gammaproteobacteria	ispE	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006629,GO:0006720,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0050515,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901576	2.1.1.182,2.7.1.148	ko:K00919,ko:K02528,ko:K16924	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096,M00582	R05634,R10716	RC00002,RC00003,RC01439,RC03257	ko00000,ko00001,ko00002,ko01000,ko02000,ko03009	3.A.1.29		iEC55989_1330.EC55989_1304,iLJ478.TM1383,iYO844.BSU00460	Bacteria	1MVU3@1224,1RP23@1236,COG1947@1,COG1947@2	NA|NA|NA	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C1_02038	199310.c1665	2.1e-185	654.8	Escherichia	prs	GO:0000287,GO:0003674,GO:0003824,GO:0004749,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006015,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016772,GO:0016778,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042301,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046391,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000			iAF1260.b1207,iAPECO1_1312.APECO1_323,iB21_1397.B21_01192,iBWG_1329.BWG_1032,iE2348C_1286.E2348C_1330,iEC042_1314.EC042_1264,iEC55989_1330.EC55989_1303,iECABU_c1320.ECABU_c14780,iECBD_1354.ECBD_2414,iECB_1328.ECB_01182,iECDH10B_1368.ECDH10B_1260,iECDH1ME8569_1439.ECDH1ME8569_1146,iECD_1391.ECD_01182,iECED1_1282.ECED1_1355,iECH74115_1262.ECH74115_1688,iECIAI1_1343.ECIAI1_1228,iECIAI39_1322.ECIAI39_1543,iECNA114_1301.ECNA114_1372,iECO103_1326.ECO103_1309,iECO111_1330.ECO111_1536,iECO26_1355.ECO26_1720,iECOK1_1307.ECOK1_1360,iECP_1309.ECP_1255,iECS88_1305.ECS88_1275,iECSE_1348.ECSE_1257,iECSF_1327.ECSF_1183,iECSP_1301.ECSP_1597,iECUMN_1333.ECUMN_1504,iECW_1372.ECW_m1293,iECs_1301.ECs1712,iEKO11_1354.EKO11_2647,iETEC_1333.ETEC_1311,iEcDH1_1363.EcDH1_2440,iEcE24377_1341.EcE24377A_1355,iEcHS_1320.EcHS_A1312,iEcSMS35_1347.EcSMS35_1935,iEcolC_1368.EcolC_2419,iG2583_1286.G2583_1478,iJO1366.b1207,iJR904.b1207,iLF82_1304.LF82_1744,iLJ478.TM1628,iNRG857_1313.NRG857_06180,iSBO_1134.SBO_1860,iSDY_1059.SDY_1256,iSSON_1240.SSON_1971,iUMN146_1321.UM146_11025,iUMNK88_1353.UMNK88_1523,iUTI89_1310.UTI89_C1401,iWFL_1372.ECW_m1293,iY75_1357.Y75_RS06300,ic_1306.c1665	Bacteria	1MW21@1224,1RMUC@1236,3XP2G@561,COG0462@1,COG0462@2	NA|NA|NA	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C1_02039	155864.EDL933_1910	6.4e-288	996.1	Escherichia	sulP	GO:0003333,GO:0003674,GO:0005215,GO:0005310,GO:0005326,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0008272,GO:0008509,GO:0008514,GO:0015075,GO:0015103,GO:0015116,GO:0015138,GO:0015141,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015238,GO:0015318,GO:0015556,GO:0015698,GO:0015711,GO:0015740,GO:0015741,GO:0015744,GO:0015800,GO:0015807,GO:0015810,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070778,GO:0071422,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0098656,GO:0098660,GO:0098661,GO:1901682,GO:1902358,GO:1902475,GO:1903825,GO:1905039		ko:K03321					ko00000,ko02000	2.A.53.3		iSbBS512_1146.SbBS512_E1370	Bacteria	1MVWV@1224,1RMCN@1236,3XMAJ@561,COG0659@1,COG0659@2	NA|NA|NA	P	Responsible for the aerobic transport of succinate from the periplasm to the cytoplasm at acidic pH. Can transport other C4-dicarboxylic acids such as aspartate and fumarate. May also play a role in the regulation of C4-dicarboxylic acid metabolism at pH 7, via regulation of expression and or activity of DctA. May act as a co-sensor of DcuS
C1_02040	1440052.EAKF1_ch0242c	1.8e-46	191.4	Escherichia	ychH	GO:0000302,GO:0006950,GO:0006979,GO:0008150,GO:0009636,GO:0009987,GO:0010035,GO:0010038,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042710,GO:0044010,GO:0044011,GO:0044764,GO:0046677,GO:0046686,GO:0050896,GO:0051703,GO:0051704,GO:0051716,GO:0070301,GO:0070887,GO:0071236,GO:0071241,GO:0071248,GO:0071276,GO:0090605,GO:0090609,GO:0097237,GO:1901700,GO:1901701											Bacteria	1MZI6@1224,1S8Y3@1236,2DB54@1,32TWR@2,3XPVG@561	NA|NA|NA	S	cellular response to cadmium ion
C1_02041	155864.EDL933_1908	6e-108	396.7	Escherichia	pth	GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006515,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019538,GO:0030163,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0052689,GO:0071704,GO:0140098,GO:0140101,GO:1901564,GO:1901565,GO:1901575	3.1.1.29	ko:K01056					ko00000,ko01000,ko03012				Bacteria	1MX1P@1224,1RPK3@1236,3XNIA@561,COG0193@1,COG0193@2	NA|NA|NA	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
C1_02042	155864.EDL933_1907	1.7e-204	718.4	Escherichia	ychF	GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0043021,GO:0043022,GO:0043023,GO:0043086,GO:0044092,GO:0044424,GO:0044464,GO:0044877,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0098772		ko:K06942					ko00000,ko03009				Bacteria	1MVM4@1224,1RMBI@1236,3XNGE@561,COG0012@1,COG0012@2	NA|NA|NA	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
C1_02043	316407.85674876	0.0	1717.6	Gammaproteobacteria	ycgV	GO:0007155,GO:0008150,GO:0009987,GO:0022610,GO:0031589,GO:0042710,GO:0043708,GO:0044764,GO:0051704,GO:0090605											Bacteria	1R3VW@1224,1RSKC@1236,COG3468@1,COG3468@2	NA|NA|NA	MU	cell adhesion involved in biofilm formation
C1_02044	469008.B21_01186	0.0	1248.8	Escherichia	dhaR	GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141		ko:K05880,ko:K21405					ko00000,ko03000				Bacteria	1NRG5@1224,1RQQD@1236,3XPI9@561,COG3284@1,COG3284@2	NA|NA|NA	KQ	PTS-dependent dihydroxyacetone kinase operon regulatory protein
C1_02045	199310.c1658	1.1e-203	715.7	Escherichia	dhaK	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019637,GO:0019751,GO:0033554,GO:0034308,GO:0042180,GO:0042182,GO:0042802,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0047324,GO:0050896,GO:0051716,GO:0061610,GO:0071704,GO:1901135,GO:1901575,GO:1901615	2.7.1.121,2.7.1.28,2.7.1.29,4.6.1.15	ko:K00863,ko:K05878	ko00051,ko00561,ko00680,ko01100,ko01120,ko01200,ko04622,map00051,map00561,map00680,map01100,map01120,map01200,map04622	M00344	R01011,R01012,R01059	RC00002,RC00015,RC00017	ko00000,ko00001,ko00002,ko01000			iEcHS_1320.EcHS_A1304,iUMNK88_1353.UMNK88_1515,iYL1228.KPN_03495	Bacteria	1MVSR@1224,1RNRQ@1236,3XP0J@561,COG2376@1,COG2376@2	NA|NA|NA	G	Dihydroxyacetone binding subunit of the dihydroxyacetone kinase, which is responsible for the phosphoenolpyruvate (PEP)- dependent phosphorylation of dihydroxyacetone via a phosphoryl group transfer from DhaL-ATP. Binds covalently dihydroxyacetone in hemiaminal linkage. DhaK acts also as corepressor of the transcription activator DhaR by binding to the sensor domain of DhaR. In the presence of dihydroxyacetone, DhaL-ADP displaces DhaK and stimulates DhaR activity. In the absence of dihydroxyacetone, DhaL-ADP is converted by the PTS to DhaL-ATP, which does not bind to DhaR
C1_02046	316407.85674873	2.4e-110	404.8	Escherichia	dhaL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0047324,GO:0097159,GO:0097367,GO:1901265,GO:1901363	2.7.1.121,2.7.1.28,2.7.1.29,4.6.1.15	ko:K00863,ko:K05879	ko00051,ko00561,ko00680,ko01100,ko01120,ko01200,ko04622,map00051,map00561,map00680,map01100,map01120,map01200,map04622	M00344	R01011,R01012,R01059	RC00002,RC00015,RC00017	ko00000,ko00001,ko00002,ko01000			iECUMN_1333.ECUMN_1495	Bacteria	1MXIB@1224,1RPJ7@1236,3XMTJ@561,COG1461@1,COG1461@2	NA|NA|NA	S	ADP-binding subunit of the dihydroxyacetone kinase, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaL-ADP is converted to DhaL-ATP via a phosphoryl group transfer from DhaM and transmits it to dihydroxyacetone binds to DhaK. DhaL acts also as coactivator of the transcription activator DhaR by binding to the sensor domain of DhaR. In the presence of dihydroxyacetone, DhaL- ADP displaces DhaK and stimulates DhaR activity. In the absence of dihydroxyacetone, DhaL-ADP is converted by the PTS to DhaL-ATP, which does not bind to DhaR
C1_02047	316407.85674872	5.4e-259	899.8	Escherichia	dhaM	GO:0000287,GO:0003674,GO:0003824,GO:0005215,GO:0005353,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005981,GO:0006109,GO:0006464,GO:0006468,GO:0006476,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006950,GO:0006974,GO:0008047,GO:0008150,GO:0008152,GO:0008643,GO:0008645,GO:0008965,GO:0008982,GO:0009401,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010033,GO:0010243,GO:0010604,GO:0010675,GO:0010676,GO:0010906,GO:0010907,GO:0015144,GO:0015145,GO:0015149,GO:0015749,GO:0015755,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0018193,GO:0018205,GO:0019197,GO:0019213,GO:0019222,GO:0019538,GO:0019897,GO:0019898,GO:0022804,GO:0022857,GO:0022877,GO:0030234,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0032445,GO:0032881,GO:0032991,GO:0033554,GO:0033558,GO:0034219,GO:0034983,GO:0035601,GO:0036211,GO:0042221,GO:0042802,GO:0043085,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043467,GO:0043470,GO:0043471,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045819,GO:0045913,GO:0046872,GO:0047324,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051119,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0060255,GO:0062012,GO:0062013,GO:0065007,GO:0065009,GO:0070873,GO:0070875,GO:0071702,GO:0071704,GO:0071944,GO:0080090,GO:0090563,GO:0098732,GO:0098772,GO:0140096,GO:1901564,GO:1901698	2.7.1.121,2.7.1.202,2.7.3.9	ko:K02768,ko:K02784,ko:K05881,ko:K08483,ko:K08485,ko:K11183,ko:K11189,ko:K11201	ko00051,ko00561,ko01100,ko01120,ko02060,map00051,map00561,map01100,map01120,map02060	M00273,M00306	R01012,R03232	RC00015,RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1,8.A.7,8.A.8.1.1		e_coli_core.b2415,iAF1260.b2415,iB21_1397.B21_02276,iB21_1397.B21_02277,iBWG_1329.BWG_2177,iE2348C_1286.E2348C_2601,iE2348C_1286.E2348C_2602,iEC042_1314.EC042_2624,iEC042_1314.EC042_2625,iEC55989_1330.EC55989_2705,iECABU_c1320.ECABU_c27360,iECBD_1354.ECBD_1265,iECBD_1354.ECBD_1266,iECB_1328.ECB_02315,iECB_1328.ECB_02316,iECDH10B_1368.ECDH10B_2580,iECDH1ME8569_1439.ECDH1ME8569_2349,iECDH1ME8569_1439.EcDH1_1246,iECD_1391.ECD_02315,iECD_1391.ECD_02316,iECED1_1282.ECED1_2859,iECH74115_1262.ECH74115_3646,iECH74115_1262.ECH74115_3647,iECIAI1_1343.ECIAI1_2473,iECIAI1_1343.ECIAI1_2474,iECIAI39_1322.ECIAI39_2561,iECIAI39_1322.ECIAI39_2562,iECNA114_1301.ECNA114_2492,iECO103_1326.ECO103_2934,iECO103_1326.ECO103_2935,iECO111_1330.ECO111_3145,iECO111_1330.ECO111_3146,iECO26_1355.ECO26_3468,iECO26_1355.ECO26_3469,iECOK1_1307.ECOK1_2732,iECP_1309.ECP_2439,iECP_1309.ECP_2440,iECS88_1305.ECS88_2605,iECSE_1348.ECSE_2706,iECSE_1348.ECSE_2707,iECSF_1327.ECSF_2279,iECSP_1301.ECSP_3363,iECSP_1301.ECSP_3364,iECUMN_1333.ECUMN_2737,iECUMN_1333.ECUMN_2738,iECW_1372.ECW_m2644,iECW_1372.ECW_m2645,iECs_1301.ECs1703,iECs_1301.ECs3287,iECs_1301.ECs3288,iEKO11_1354.EKO11_1312,iEKO11_1354.EKO11_1313,iETEC_1333.ETEC_2528,iEcDH1_1363.EcDH1_1246,iEcE24377_1341.EcE24377A_2702,iEcE24377_1341.EcE24377A_2703,iEcHS_1320.EcHS_A2550,iEcHS_1320.EcHS_A2551,iEcSMS35_1347.EcSMS35_2570,iEcSMS35_1347.EcSMS35_2571,iEcolC_1368.EcolC_1262,iEcolC_1368.EcolC_1263,iG2583_1286.G2583_2947,iJO1366.b2415,iJR904.b2415,iLF82_1304.LF82_1769,iLF82_1304.LF82_1770,iNRG857_1313.NRG857_12110,iNRG857_1313.NRG857_12115,iSBO_1134.SBO_2155,iSBO_1134.SBO_2439,iSBO_1134.SBO_2440,iSDY_1059.SDY_2612,iSDY_1059.SDY_2613,iSFV_1184.SFV_2467,iSFV_1184.SFV_2468,iSF_1195.SF1201,iSF_1195.SF2470,iSF_1195.SF2471,iSFxv_1172.SFxv_2719,iSFxv_1172.SFxv_2720,iSSON_1240.SSON_2504,iSSON_1240.SSON_2505,iS_1188.S1285,iS_1188.S2616,iS_1188.S2617,iSbBS512_1146.SbBS512_E0794,iSbBS512_1146.SbBS512_E2765,iUMN146_1321.UM146_04545,iUMNK88_1353.UMNK88_3017,iUMNK88_1353.UMNK88_3018,iUTI89_1310.UTI89_C1391,iUTI89_1310.UTI89_C2749,iWFL_1372.ECW_m2644,iWFL_1372.ECW_m2645,iY75_1357.Y75_RS12655,iZ_1308.Z1969,iZ_1308.Z3681,iZ_1308.Z3682,ic_1306.c2950	Bacteria	1MUT8@1224,1RRCZ@1236,3XN0F@561,COG1080@1,COG1080@2,COG1925@1,COG1925@2,COG3412@1,COG3412@2	NA|NA|NA	G	Protein deacetylase that removes acetyl groups on specific lysine residues in target proteins. Regulates transcription by catalyzing deacetylation of 'Lys-52' and 'Lys-62' of the transcriptional repressor RutR. Is also able to deacetylate NhoA and RluC in vitro. Targets a distinct set of substrates compared to CobB
C1_02048	316407.1651595	0.0	1166.0	Escherichia	treA	GO:0003674,GO:0003824,GO:0004553,GO:0004555,GO:0005575,GO:0005623,GO:0005975,GO:0005984,GO:0005991,GO:0005993,GO:0006950,GO:0006970,GO:0006972,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009628,GO:0009987,GO:0015926,GO:0015927,GO:0016052,GO:0016787,GO:0016798,GO:0030288,GO:0030313,GO:0031975,GO:0033554,GO:0042597,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044464,GO:0046352,GO:0050896,GO:0051716,GO:0071214,GO:0071470,GO:0071474,GO:0071704,GO:0104004,GO:1901575	3.2.1.28	ko:K01194,ko:K03931	ko00500,ko01100,map00500,map01100		R00010	RC00049	ko00000,ko00001,ko00537,ko01000		GH37,GH63	iAF1260.b1197,iB21_1397.B21_01182,iBWG_1329.BWG_1022,iECBD_1354.ECBD_2425,iECB_1328.ECB_01172,iECDH10B_1368.ECDH10B_1250,iECDH1ME8569_1439.ECDH1ME8569_1136,iECD_1391.ECD_01172,iECUMN_1333.ECUMN_1493,iETEC_1333.ETEC_1301,iEcDH1_1363.EcDH1_2451,iEcHS_1320.EcHS_A1301,iEcolC_1368.EcolC_2429,iJO1366.b1197,iJR904.b1197,iSBO_1134.SBO_3518,iY75_1357.Y75_RS06245	Bacteria	1MWSM@1224,1RMFP@1236,3XMWX@561,COG1626@1,COG1626@2	NA|NA|NA	G	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
C1_02049	316407.85674871	1.1e-77	295.8	Escherichia	ycgY												Bacteria	1NWE0@1224,1SPQA@1236,2CIJV@1,33XM0@2,3XR1U@561	NA|NA|NA		
C1_02050	469008.B21_01180	2.7e-36	157.5	Escherichia	ymgE												Bacteria	1N72W@1224,1S8YP@1236,3XQ0Y@561,COG2261@1,COG2261@2	NA|NA|NA	S	Transglycosylase associated protein
C1_02051	316407.85674870	8.9e-133	479.6	Escherichia	ycgR	GO:0000166,GO:0001539,GO:0003674,GO:0005488,GO:0006928,GO:0008144,GO:0008150,GO:0009987,GO:0017076,GO:0019001,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0032879,GO:0035438,GO:0036094,GO:0040011,GO:0040012,GO:0043167,GO:0043168,GO:0048870,GO:0050789,GO:0050794,GO:0051179,GO:0051270,GO:0051674,GO:0065007,GO:0071945,GO:0071973,GO:0097159,GO:0097367,GO:0097588,GO:1901265,GO:1901363,GO:1902021,GO:2000145		ko:K21087	ko02026,map02026				ko00000,ko00001				Bacteria	1MX00@1224,1RY2F@1236,3XMYZ@561,COG5581@1,COG5581@2	NA|NA|NA	M	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C1_02052	155864.EDL933_1888	6.5e-113	413.3	Escherichia	emtA	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008932,GO:0008933,GO:0009279,GO:0016020,GO:0016740,GO:0016757,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0061783,GO:0071944		ko:K08306,ko:K08308,ko:K08309					ko00000,ko01000,ko01011		GH23	iAF1260.b1193,iB21_1397.B21_01178,iBWG_1329.BWG_1018,iECBD_1354.ECBD_2429,iECB_1328.ECB_01168,iECDH10B_1368.ECDH10B_1246,iECDH1ME8569_1439.ECDH1ME8569_1132,iECD_1391.ECD_01168,iEcDH1_1363.EcDH1_2455,iEcolC_1368.EcolC_2432,iG2583_1286.G2583_3622,iJO1366.b1193,iUMNK88_1353.UMNK88_1507,iY75_1357.Y75_RS06225	Bacteria	1MWFU@1224,1RRJC@1236,3XP3G@561,COG0741@1,COG0741@2	NA|NA|NA	M	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division. Preferentially cleaves at a distance of more than two disaccharide units from the ends of the glycan chain
C1_02053	199310.c1641	8.4e-173	612.8	Escherichia	ldcA	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009050,GO:0009056,GO:0009254,GO:0009987,GO:0016787,GO:0019538,GO:0030203,GO:0034641,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575	3.4.17.13	ko:K01297					ko00000,ko01000,ko01002,ko01011			iAPECO1_1312.APECO1_304,iECABU_c1320.ECABU_c14580,iECED1_1282.ECED1_1334,iECOK1_1307.ECOK1_1338,iECS88_1305.ECS88_1255,iLF82_1304.LF82_1171,iNRG857_1313.NRG857_06085,iSFV_1184.SFV_1201,iSFxv_1172.SFxv_1357,iS_1188.S1271,iUMN146_1321.UM146_11125,iUTI89_1310.UTI89_C1378,ic_1306.c1641	Bacteria	1MWIY@1224,1RQT8@1236,3XMJ8@561,COG1619@1,COG1619@2	NA|NA|NA	V	Releases the terminal D-alanine residue from the cytoplasmic tetrapeptide recycling product L-Ala-gamma-D-Glu-meso- Dap-D-Ala. To a lesser extent, can also cleave D-Ala from murein derivatives containing the tetrapeptide, i.e. MurNAc-tetrapeptide, UDP-MurNAc-tetrapeptide, GlcNAc-MurNAc-tetrapeptide, and GlcNAc- anhMurNAc-tetrapeptide. Does not act on murein sacculi or cross- linked muropeptides. The tripeptides produced by the LcdA reaction can then be reused as peptidoglycan building blocks
C1_02054	155864.EDL933_1886	0.0	1087.4	Escherichia	nhaP2	GO:0003674,GO:0005215,GO:0005451,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006884,GO:0008150,GO:0008324,GO:0008361,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015079,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015386,GO:0015491,GO:0015672,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022804,GO:0022821,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0032535,GO:0034220,GO:0042592,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0065007,GO:0065008,GO:0071804,GO:0071805,GO:0071840,GO:0071944,GO:0090066,GO:0098655,GO:0098660,GO:0098662,GO:0099516,GO:1902600		ko:K11105					ko00000,ko02000	2.A.36.6			Bacteria	1MVKV@1224,1RMCA@1236,3XMWT@561,COG3263@1,COG3263@2	NA|NA|NA	P	) H( ) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels
C1_02056	155864.EDL933_1884	4.8e-204	716.8	Escherichia	alr	GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0006022,GO:0006023,GO:0006024,GO:0006082,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008784,GO:0009058,GO:0009059,GO:0009078,GO:0009079,GO:0009252,GO:0009273,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0019842,GO:0030170,GO:0030203,GO:0030632,GO:0034645,GO:0036094,GO:0036361,GO:0040007,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044281,GO:0044283,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0047661,GO:0048037,GO:0050662,GO:0070279,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502		R00401	RC00285	ko00000,ko00001,ko01000,ko01011			iEC55989_1330.EC55989_1285,iECIAI39_1322.ECIAI39_1880,iECO103_1326.ECO103_1292,iECO26_1355.ECO26_1703,iECSE_1348.ECSE_1238,iECUMN_1333.ECUMN_1479,iECW_1372.ECW_m1275,iEKO11_1354.EKO11_2666,iEcE24377_1341.EcE24377A_1335,iSBO_1134.SBO_4064,iSbBS512_1146.SbBS512_E4542,iWFL_1372.ECW_m1275,iYL1228.KPN_02308	Bacteria	1MV0Q@1224,1RM8U@1236,3XP41@561,COG0787@1,COG0787@2	NA|NA|NA	E	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C1_02057	199310.c1638	3.8e-251	873.6	Escherichia	dadA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0008718,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009324,GO:0009987,GO:0016020,GO:0016054,GO:0016491,GO:0016638,GO:0019478,GO:0019480,GO:0019752,GO:0032991,GO:0042851,GO:0042853,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046144,GO:0046395,GO:0046416,GO:0046436,GO:0055114,GO:0055130,GO:0071704,GO:0071944,GO:0098796,GO:0098797,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204	1.4.5.1	ko:K00285	ko00360,map00360		R01374,R09493	RC00006,RC00025	ko00000,ko00001,ko01000			iSBO_1134.SBO_1883,iSFV_1184.SFV_1196,iSF_1195.SF1178,iSFxv_1172.SFxv_1352,iS_1188.S1266,iUMNK88_1353.UMNK88_1502,iYL1228.KPN_02309	Bacteria	1MVIZ@1224,1RQ50@1236,3XNX8@561,COG0665@1,COG0665@2	NA|NA|NA	E	Oxidative deamination of D-amino acids
C1_02058	316407.4062773	3.5e-304	1050.0	Escherichia	spoVR	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716		ko:K06415					ko00000				Bacteria	1MW6U@1224,1RPU2@1236,3XMG4@561,COG2719@1,COG2719@2	NA|NA|NA	S	cellular response to DNA damage stimulus
C1_02059	1440052.EAKF1_ch0265c	1.9e-135	488.4	Escherichia	fadR	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006355,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010563,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019216,GO:0019217,GO:0019219,GO:0019220,GO:0019222,GO:0019395,GO:0019752,GO:0030258,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032787,GO:0032991,GO:0032993,GO:0034440,GO:0042304,GO:0043436,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045723,GO:0045833,GO:0045834,GO:0045892,GO:0045893,GO:0045923,GO:0045934,GO:0045935,GO:0045936,GO:0046889,GO:0046890,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051252,GO:0051253,GO:0051254,GO:0055114,GO:0060255,GO:0062012,GO:0062013,GO:0065007,GO:0071071,GO:0071072,GO:0071704,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1903725,GO:1903726,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K03603,ko:K05799,ko:K22104					ko00000,ko03000				Bacteria	1MW7M@1224,1RMRE@1236,3XP0P@561,COG2186@1,COG2186@2	NA|NA|NA	K	Multifunctional regulator of fatty acid metabolism
C1_02060	155864.EDL933_1880	5.2e-276	956.4	Escherichia	nhaB	GO:0003674,GO:0005215,GO:0005451,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006873,GO:0006885,GO:0008150,GO:0008324,GO:0009987,GO:0010035,GO:0010038,GO:0010226,GO:0015075,GO:0015077,GO:0015078,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015491,GO:0015672,GO:0016020,GO:0019725,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030004,GO:0030641,GO:0034220,GO:0035725,GO:0042221,GO:0042592,GO:0044464,GO:0045851,GO:0046873,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051234,GO:0051452,GO:0051453,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099516,GO:1902600		ko:K03314					ko00000,ko02000	2.A.34.1		iECP_1309.ECP_1229,iLF82_1304.LF82_1485,iNRG857_1313.NRG857_06055,iUTI89_1310.UTI89_C1372	Bacteria	1MV0F@1224,1RPE3@1236,3XNNA@561,COG3067@1,COG3067@2	NA|NA|NA	P	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C1_02061	198214.SF1174	4.4e-97	360.5	Gammaproteobacteria	dsbB	GO:0003674,GO:0003824,GO:0006091,GO:0006457,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0022900,GO:0044237,GO:0050896,GO:0055114		ko:K03611					ko00000,ko03110	5.A.2.1		iAF1260.b1185,iB21_1397.B21_01170,iBWG_1329.BWG_1010,iEC042_1314.EC042_1234,iEC55989_1330.EC55989_1280,iECBD_1354.ECBD_2437,iECB_1328.ECB_01160,iECDH10B_1368.ECDH10B_1238,iECDH1ME8569_1439.ECDH1ME8569_1124,iECD_1391.ECD_01160,iECED1_1282.ECED1_1327,iECIAI1_1343.ECIAI1_1202,iECO103_1326.ECO103_1287,iECSP_1301.ECSP_1582,iECUMN_1333.ECUMN_1474,iECs_1301.ECs1680,iETEC_1333.ETEC_1289,iEcDH1_1363.EcDH1_2463,iEcHS_1320.EcHS_A1288,iEcSMS35_1347.EcSMS35_1964,iEcolC_1368.EcolC_2440,iG2583_1286.G2583_1446,iJO1366.b1185,iSDY_1059.SDY_1222,iY75_1357.Y75_RS06185	Bacteria	1RIJE@1224,1S6WD@1236,COG1495@1,COG1495@2	NA|NA|NA	O	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C1_02062	316407.1651581	5.7e-244	849.7	Escherichia	umuC	GO:0000731,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0003887,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009355,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016021,GO:0016462,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0018130,GO:0019438,GO:0019985,GO:0031224,GO:0031668,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044425,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071496,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02346,ko:K03502					ko00000,ko01000,ko03400				Bacteria	1MUUH@1224,1RMT1@1236,3XQ8B@561,COG0389@1,COG0389@2	NA|NA|NA	L	efficiency is maximal in the presence of the beta sliding-clamp and clamp-loading complex of DNA polymerase III plus single-stranded binding protein (SSB). RecA and to a lesser extent the beta clamp- complex may target Pol V to replication complexes stalled at DNA template lesions
C1_02063	155864.EDL933_1877	1.2e-70	272.3	Escherichia	umuD	GO:0000731,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0003887,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009355,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016462,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0018130,GO:0019438,GO:0019985,GO:0031668,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0042623,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071496,GO:0071704,GO:0071897,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990234		ko:K03503					ko00000,ko01000,ko01002,ko03400				Bacteria	1MZFA@1224,1S5X5@1236,3XPXS@561,COG1974@1,COG1974@2	NA|NA|NA	KT	Involved in UV protection and mutation. Poorly processive, error-prone DNA polymerase involved in translesion repair. Essential for induced (or SOS) mutagenesis. Able to replicate DNA across DNA lesions (thymine photodimers and abasic sites, called translesion synthesis) in the presence of activated RecA
C1_02064	155864.EDL933_1876	4.1e-11	72.8	Gammaproteobacteria	hlyE	GO:0001897,GO:0001906,GO:0001907,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005623,GO:0008150,GO:0009405,GO:0009987,GO:0010941,GO:0019835,GO:0019836,GO:0031640,GO:0035821,GO:0042597,GO:0042802,GO:0042981,GO:0043067,GO:0044003,GO:0044004,GO:0044179,GO:0044364,GO:0044403,GO:0044419,GO:0044464,GO:0044531,GO:0044532,GO:0044764,GO:0050789,GO:0050794,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0065007		ko:K11139					ko00000,ko02042				Bacteria	1R8QT@1224,1RS8N@1236,28N3N@1,2ZB9A@2	NA|NA|NA	O	Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells
C1_02065	316407.85674866	1e-122	446.0	Gammaproteobacteria	hlyE	GO:0001897,GO:0001906,GO:0001907,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005623,GO:0008150,GO:0009405,GO:0009987,GO:0010941,GO:0019835,GO:0019836,GO:0031640,GO:0035821,GO:0042597,GO:0042802,GO:0042981,GO:0043067,GO:0044003,GO:0044004,GO:0044179,GO:0044364,GO:0044403,GO:0044419,GO:0044464,GO:0044531,GO:0044532,GO:0044764,GO:0050789,GO:0050794,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0065007		ko:K11139					ko00000,ko02042				Bacteria	1R8QT@1224,1RS8N@1236,28N3N@1,2ZB9A@2	NA|NA|NA	O	Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells
C1_02066	199310.c1629	5e-91	340.5	Escherichia	ycgN			ko:K09160					ko00000				Bacteria	1RHMX@1224,1S5XU@1236,3XPDK@561,COG2983@1,COG2983@2	NA|NA|NA	S	Putative zinc- or iron-chelating domain
C1_02067	155864.EDL933_1873	2.2e-122	444.9	Escherichia	ycgM		3.7.1.20	ko:K16165	ko00350,ko01100,ko01120,map00350,map01100,map01120		R01085	RC00326,RC00446	ko00000,ko00001,ko01000				Bacteria	1MVFA@1224,1RN6Y@1236,3XNKX@561,COG0179@1,COG0179@2	NA|NA|NA	Q	metal ion binding
C1_02068	198214.SF1168	4.2e-49	200.3	Gammaproteobacteria	ycgL			ko:K09902					ko00000				Bacteria	1N83J@1224,1SCCD@1236,COG3100@1,COG3100@2	NA|NA|NA	S	YcgL domain-containing protein
C1_02069	469008.B21_01163	9.3e-68	262.7	Escherichia	pliG	GO:0003674,GO:0004857,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030234,GO:0042597,GO:0043086,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0060241,GO:0065007,GO:0065009,GO:0098772											Bacteria	1N73H@1224,1SDSZ@1236,2C1UG@1,32ZD3@2,3XQ6I@561	NA|NA|NA	S	lysozyme inhibitor activity
C1_02070	155864.EDL933_1869	4.4e-64	250.4	Gammaproteobacteria	ycgJ												Bacteria	1RI8H@1224,1S9I8@1236,2BV6C@1,32QJR@2	NA|NA|NA	S	Fels-1 Prophage Protein-like
C1_02071	155864.EDL933_1868	1.7e-125	455.3	Escherichia	minC	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0007346,GO:0008150,GO:0009987,GO:0010564,GO:0032465,GO:0032954,GO:0032955,GO:0042802,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051301,GO:0051302,GO:0051726,GO:0060187,GO:0065007,GO:1901891,GO:1902412,GO:1903436		ko:K03610,ko:K09749					ko00000,ko03036,ko04812				Bacteria	1RHVN@1224,1S6K8@1236,3XNRJ@561,COG0850@1,COG0850@2	NA|NA|NA	D	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization
C1_02072	155864.EDL933_1867	1.7e-145	521.9	Escherichia	minD	GO:0000166,GO:0000910,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0007049,GO:0007059,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022402,GO:0030554,GO:0031224,GO:0031226,GO:0032506,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036214,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051179,GO:0051301,GO:0051302,GO:0051782,GO:0060187,GO:0061640,GO:0065007,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363		ko:K03609					ko00000,ko03036,ko04812				Bacteria	1MUEU@1224,1RNJ0@1236,3XNRZ@561,COG2894@1,COG2894@2	NA|NA|NA	D	ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings
C1_02073	1440052.EAKF1_ch0279	1.2e-39	168.7	Escherichia	minE	GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0000918,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0007049,GO:0007346,GO:0008150,GO:0009987,GO:0010564,GO:0016020,GO:0016043,GO:0022402,GO:0022607,GO:0032465,GO:0032506,GO:0032954,GO:0032955,GO:0042802,GO:0044085,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051301,GO:0051302,GO:0051726,GO:0061640,GO:0065007,GO:0071840,GO:0071944,GO:0090529,GO:1901891,GO:1902410,GO:1902412,GO:1903047,GO:1903436		ko:K03608					ko00000,ko03036,ko04812				Bacteria	1N6QD@1224,1SC8W@1236,3XPUI@561,COG0851@1,COG0851@2	NA|NA|NA	D	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C1_02074	155864.EDL933_3815	6.9e-53	213.0	Escherichia	ypjA												Bacteria	1R9A8@1224,1RS0C@1236,3XQQT@561,COG3468@1,COG3468@2	NA|NA|NA	MU	cell adhesion
C1_02075	1440052.EAKF1_ch0281	1.5e-11	75.5	Escherichia	ymgG												Bacteria	1N6AZ@1224,1SBA7@1236,2E2G4@1,32XK9@2,3XPUW@561	NA|NA|NA	S	Glycine-zipper domain
C1_02076	198214.SF1158	9.1e-53	212.6	Gammaproteobacteria	ymgD	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464											Bacteria	1MZD0@1224,1SC09@1236,2E1DM@1,32WSV@2	NA|NA|NA	S	YmgD protein
C1_02077	198214.SF1157	0.0	1484.2	Gammaproteobacteria				ko:K12678,ko:K12679	ko05131,map05131				ko00000,ko00001,ko02000,ko02044	1.B.12.1.1,1.B.12.1.2,1.B.12.1.3			Bacteria	1R8WV@1224,1RPXJ@1236,COG3468@1,COG3468@2	NA|NA|NA	MU	outer membrane autotransporter barrel domain protein
C1_02078	469008.B21_01153	2.1e-07	61.2	Bacteria													Bacteria	COG3468@1,COG3468@2	NA|NA|NA	MU	cell adhesion
C1_02080	469008.B21_01151	2.2e-287	994.2	Escherichia	ycgG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.1.4.52	ko:K13244,ko:K21090	ko02026,map02026		R08991	RC00296	ko00000,ko00001,ko01000				Bacteria	1N299@1224,1RNP4@1236,3XQT7@561,COG2200@1,COG2200@2	NA|NA|NA	T	cyclic-guanylate-specific phosphodiesterase activity
C1_02081	316407.4062745	6.9e-37	159.5	Gammaproteobacteria	ymgC												Bacteria	1P8S7@1224,1SW31@1236,294ER@1,2ZRUM@2	NA|NA|NA		
C1_02082	316407.85674858	1.3e-38	165.2	Escherichia	ariR	GO:0000302,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006950,GO:0006979,GO:0008150,GO:0009636,GO:0010035,GO:0042221,GO:0042493,GO:0042542,GO:0046677,GO:0050896,GO:0097159,GO:1901363,GO:1901700		ko:K21976					ko00000				Bacteria	1N7EC@1224,1SFSW@1236,2ECN4@1,336K1@2,3XQ5H@561	NA|NA|NA	K	Probably a connector protein for RcsB C regulation of biofilm and acid-resistance, providing additional signal input into the two-component signaling pathway. May serve to stimulate biofilm maturation, via the Rcs phosphorelay. Regulates expression of genes involved in acid-resistance and biofilm formation, including the RcsB C two-component system. May be a non-specific DNA-binding protein that binds genes and or intergenic regions via a geometric recognition. Also confers resistance to H(2)O(2). Overexpression at 28 and 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB
C1_02083	316407.85674856	1.6e-35	154.8	Escherichia	ycgZ	GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K21974					ko00000				Bacteria	1N1WZ@1224,1SB5M@1236,2CBKZ@1,32RTK@2,3XQ4P@561	NA|NA|NA	S	Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component
C1_02084	316407.4062744	1.3e-226	792.0	Escherichia	ycgF	GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0008134,GO:0008150,GO:0009314,GO:0009416,GO:0009628,GO:0009637,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0033613,GO:0036094,GO:0043167,GO:0043168,GO:0043433,GO:0044092,GO:0048037,GO:0048519,GO:0050660,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051090,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0065009,GO:0070491,GO:0080090,GO:0097159,GO:1901265,GO:1901363,GO:1903506,GO:2000112,GO:2001141		ko:K21973					ko00000				Bacteria	1MVJY@1224,1RPDW@1236,3XNKP@561,COG2200@1,COG2200@2	NA|NA|NA	T	Binds to and releases the BluR repressor from its bound DNA target in a blue light-dependent (470 nm) fashion. A shift to low temperature also triggers a BluF-mediated relief of repression by BluR, suggesting BluF may serve as a thermometer. Blue light may act to increase the affinity of BluF for BluR, allowing it to be released from its operator. The protein has a reversible photocycle, and undergoes structural changes, probably in the EAL domain, in response to light
C1_02085	316407.4062743	4.9e-139	500.4	Escherichia	ycgE	GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K21089,ko:K21972,ko:K22491	ko02026,map02026				ko00000,ko00001,ko03000				Bacteria	1R9SN@1224,1S967@1236,3XNWY@561,COG0789@1,COG0789@2	NA|NA|NA	K	Controls the expression of several small proteins that may play a role in biofilm maturation. Binds to and represses the operator of the ycgZ-ymgA-ariR-ymgC operon and also regulates ynaK. Binding is antagonized by BluF upon blue light (470 nm) irradiation. Blue light may increase the affinity of BluF for BluR, allowing it to be released from its operator
C1_02086	316407.85674855	4.1e-71	273.9	Escherichia	ycgX												Bacteria	1N5MB@1224,1S80R@1236,3XR27@561,COG5562@1,COG5562@2	NA|NA|NA	S	Protein of unknown function (DUF1398)
C1_02087	1440052.EAKF1_ch0292c	1.5e-241	841.6	Escherichia	icd	GO:0003674,GO:0003824,GO:0004448,GO:0004450,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0022900,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0055114	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000			e_coli_core.b1136,iAF1260.b1136,iECDH1ME8569_1439.ECDH1ME8569_1071,iEcDH1_1363.EcDH1_2511,iJO1366.b1136,iJR904.b1136,iY75_1357.Y75_RS05930,iYL1228.KPN_01144	Bacteria	1MW3J@1224,1RNMD@1236,3XMJ1@561,COG0538@1,COG0538@2	NA|NA|NA	C	Isocitrate dehydrogenase
C1_02088	316407.4062699	1e-119	436.0	Escherichia	rluE	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.19,5.4.99.20,5.4.99.22	ko:K06178,ko:K06181,ko:K06183					ko00000,ko01000,ko03009				Bacteria	1R9VV@1224,1S1ZX@1236,3XMPV@561,COG1187@1,COG1187@2	NA|NA|NA	J	Responsible for synthesis of pseudouridine from uracil- 2457 in 23S ribosomal RNA
C1_02089	155864.EDL933_1803	3.9e-86	323.9	Escherichia	nudJ	GO:0003674,GO:0003824,GO:0004787,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017110,GO:0017111	3.6.1.55	ko:K03574,ko:K12152					ko00000,ko01000,ko03400			iSbBS512_1146.SbBS512_E1312	Bacteria	1N03W@1224,1S970@1236,3XNRP@561,COG1051@1,COG1051@2	NA|NA|NA	F	Belongs to the Nudix hydrolase family. NudJ subfamily
C1_02090	316407.4062697	2.2e-215	754.6	Escherichia	mnmA	GO:0001510,GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0003824,GO:0004808,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016782,GO:0016783,GO:0030488,GO:0032259,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.8.1.13	ko:K00566	ko04122,map04122		R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016				Bacteria	1MUT1@1224,1RMAK@1236,3XN22@561,COG0482@1,COG0482@2	NA|NA|NA	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis. Sulfur is provided by IscS, via a sulfur-relay system. Binds ATP and its substrate tRNAs
C1_02091	316407.4062696	3.8e-111	407.5	Escherichia	hflD	GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009898,GO:0016020,GO:0019897,GO:0019898,GO:0031234,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0071944,GO:0098552,GO:0098562	4.3.2.2	ko:K01756,ko:K07153	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000				Bacteria	1RI8B@1224,1RPCC@1236,3XMJX@561,COG2915@1,COG2915@2	NA|NA|NA	S	Negative regulator of phage lambda lysogenization. Contributes to the degradation of the phage regulatory protein CII. Acts probably by holding CII on the membrane surface, away from the target promoters, but close to the FtsH protease
C1_02092	155864.EDL933_1800	1.7e-262	911.4	Escherichia	purB	GO:0003674,GO:0003824,GO:0004018,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000			iAF1260.b1131,iBWG_1329.BWG_0979,iE2348C_1286.E2348C_1272,iEC042_1314.EC042_1202,iECABU_c1320.ECABU_c13450,iECDH10B_1368.ECDH10B_1203,iECP_1309.ECP_1126,iECUMN_1333.ECUMN_1375,iETEC_1333.ETEC_1255,iEcHS_1320.EcHS_A1251,iEcolC_1368.EcolC_2472,iJO1366.b1131,iJR904.b1131,iLF82_1304.LF82_1774,iNRG857_1313.NRG857_05460,iY75_1357.Y75_RS05905,ic_1306.c1510	Bacteria	1MV4B@1224,1RN93@1236,3XNCV@561,COG0015@1,COG0015@2	NA|NA|NA	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C1_02093	198214.SF1149	7.9e-120	436.4	Gammaproteobacteria													Bacteria	1N0YI@1224,1RMWT@1236,COG0745@1,COG0745@2	NA|NA|NA	K	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
C1_02094	316407.1651557	1.5e-269	934.9	Escherichia													Bacteria	1QTVU@1224,1RPFY@1236,3XMJ7@561,COG0642@1,COG2205@2	NA|NA|NA	T	PhoQ Sensor
C1_02095	316407.4062695	1.4e-225	788.5	Escherichia	ycfD	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0016491,GO:0016705,GO:0016706,GO:0018193,GO:0018195,GO:0019538,GO:0030961,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046914,GO:0051213,GO:0055114,GO:0071704,GO:1901564	1.14.11.47	ko:K18850					ko00000,ko01000,ko03009				Bacteria	1MW30@1224,1RN2Q@1236,3XN3B@561,COG2850@1,COG2850@2	NA|NA|NA	S	peptidyl-arginine hydroxylation
C1_02096	469008.B21_01133	1.1e-236	825.5	Escherichia	pepT	GO:0003674,GO:0003824,GO:0004177,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0034641,GO:0034701,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045148,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.11.4	ko:K01258					ko00000,ko01000,ko01002				Bacteria	1MV7D@1224,1RMKZ@1236,3XM5J@561,COG2195@1,COG2195@2	NA|NA|NA	E	Cleaves the N-terminal amino acid of tripeptides
C1_02097	469008.B21_01132	1.4e-212	745.3	Escherichia	potA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008144,GO:0008150,GO:0008324,GO:0008519,GO:0015075,GO:0015101,GO:0015203,GO:0015399,GO:0015405,GO:0015417,GO:0015595,GO:0015606,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0015848,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0031224,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072488,GO:0097159,GO:0097367,GO:0098533,GO:0098655,GO:0098796,GO:0098797,GO:1901265,GO:1901363,GO:1902047,GO:1902494,GO:1902495,GO:1903711,GO:1904949,GO:1990351	3.6.3.31	ko:K11072	ko02010,map02010	M00299			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11.1		iB21_1397.B21_01132,iECBD_1354.ECBD_2473,iECB_1328.ECB_01124,iECD_1391.ECD_01124,iECO111_1330.ECO111_1474,iECO26_1355.ECO26_1643,iEcHS_1320.EcHS_A1246,iEcolC_1368.EcolC_2477,iSBO_1134.SBO_1915,iSSON_1240.SSON_1144,iSbBS512_1146.SbBS512_E1304,iUMNK88_1353.UMNK88_1456	Bacteria	1MU3I@1224,1RNPX@1236,3XMSQ@561,COG3842@1,COG3842@2	NA|NA|NA	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
C1_02098	362663.ECP_1119	2.2e-151	541.6	Escherichia	potB	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0008519,GO:0015075,GO:0015101,GO:0015203,GO:0015399,GO:0015405,GO:0015417,GO:0015595,GO:0015606,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0015848,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072488,GO:0098533,GO:0098655,GO:0098796,GO:0098797,GO:1902047,GO:1902494,GO:1902495,GO:1903711,GO:1904949,GO:1990351		ko:K11071	ko02010,map02010	M00299			ko00000,ko00001,ko00002,ko02000	3.A.1.11.1		iE2348C_1286.E2348C_1266,iECUMN_1333.ECUMN_1368,iSBO_1134.SBO_1916	Bacteria	1MVGM@1224,1RNNZ@1236,3XPCI@561,COG1176@1,COG1176@2	NA|NA|NA	P	Binding-protein-dependent transport system inner membrane component
C1_02099	155864.EDL933_1700	1.6e-135	488.8	Escherichia	potC	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0008519,GO:0015075,GO:0015101,GO:0015203,GO:0015399,GO:0015405,GO:0015417,GO:0015595,GO:0015606,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0015848,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072488,GO:0098533,GO:0098655,GO:0098796,GO:0098797,GO:1902047,GO:1902494,GO:1902495,GO:1903711,GO:1904949,GO:1990351		ko:K11070,ko:K11074	ko02010,map02010	M00299,M00300			ko00000,ko00001,ko00002,ko02000	3.A.1.11.1,3.A.1.11.2		iG2583_1286.G2583_1088,iSBO_1134.SBO_1939	Bacteria	1MVC5@1224,1RQB7@1236,3XP5B@561,COG1177@1,COG1177@2	NA|NA|NA	P	Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine
C1_02100	198214.SF1125	1.4e-203	715.3	Gammaproteobacteria	potD	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0015848,GO:0019808,GO:0019809,GO:0019810,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0051179,GO:0051234,GO:0070405,GO:0071702,GO:0071705		ko:K11069,ko:K11070	ko02010,map02010	M00299			ko00000,ko00001,ko00002,ko02000	3.A.1.11.1		iSbBS512_1146.SbBS512_E2202	Bacteria	1MUYW@1224,1RM7W@1236,COG0687@1,COG0687@2	NA|NA|NA	P	Required for the activity of the bacterial periplasmic transport system of putrescine
C1_02101	1440052.EAKF1_ch0307	1.2e-74	285.8	Escherichia	ymfA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1NKBF@1224,1TGGD@1236,2E9YS@1,3344A@2,3XQZJ@561	NA|NA|NA	S	Protein of unknown function (DUF3592)
C1_02102	316407.4062693	3e-134	484.6	Escherichia	ycfZ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.4.24.3	ko:K01387,ko:K06872					ko00000,ko01000,ko01002,ko02042				Bacteria	1PD03@1224,1SY68@1236,3XM72@561,COG1512@1,COG1512@2	NA|NA|NA	S	TPM domain
C1_02103	155864.EDL933_1698	3.2e-155	554.3	Escherichia	cobB	GO:0002252,GO:0002376,GO:0003674,GO:0003824,GO:0006464,GO:0006476,GO:0006807,GO:0006935,GO:0006950,GO:0006952,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009615,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018205,GO:0019213,GO:0019538,GO:0033558,GO:0034979,GO:0034983,GO:0035601,GO:0036048,GO:0036049,GO:0036055,GO:0036211,GO:0040011,GO:0042221,GO:0042330,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0051607,GO:0051704,GO:0051707,GO:0071704,GO:0098542,GO:0098732,GO:0140096,GO:1901564		ko:K12410					ko00000,ko01000				Bacteria	1MUK1@1224,1RMX5@1236,3XMVH@561,COG0846@1,COG0846@2	NA|NA|NA	K	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C1_02104	316407.4062691	1.1e-177	629.0	Escherichia	nagK	GO:0003674,GO:0003824,GO:0004396,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019318,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045127,GO:0046835,GO:0071704	2.7.1.4,2.7.1.59	ko:K00847,ko:K00884	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100		R00760,R00867,R01201,R03920	RC00002,RC00017	ko00000,ko00001,ko01000			iE2348C_1286.E2348C_1211,iECSE_1348.ECSE_0415,iEcHS_1320.EcHS_A0462,iEcHS_1320.EcHS_A1241,iEcolC_1368.EcolC_2482	Bacteria	1MU94@1224,1RNHE@1236,3XN5F@561,COG1940@1,COG1940@2	NA|NA|NA	F	Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P
C1_02105	316407.4062690	8.9e-226	789.3	Escherichia	lolE	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008104,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0034613,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0070727,GO:0071944,GO:0072657,GO:0089705,GO:0098796,GO:0098797,GO:1990778		ko:K02004,ko:K09808	ko02010,map02010	M00255,M00258			ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.125			Bacteria	1MVV7@1224,1RMP9@1236,3XNMR@561,COG4591@1,COG4591@2	NA|NA|NA	M	system transmembrane protein lolE
C1_02106	199310.c1392	6.5e-125	453.4	Escherichia	lolD	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006807,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008152,GO:0015031,GO:0015399,GO:0015405,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0022804,GO:0022857,GO:0030554,GO:0031224,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0042157,GO:0042160,GO:0042623,GO:0042626,GO:0042886,GO:0042953,GO:0043167,GO:0043168,GO:0043170,GO:0043190,GO:0043492,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0045184,GO:0051179,GO:0051234,GO:0051641,GO:0055085,GO:0070727,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0072657,GO:0089705,GO:0097159,GO:0097367,GO:0098533,GO:0098796,GO:0098797,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1902495,GO:1904949,GO:1990351,GO:1990778		ko:K09810	ko02010,map02010	M00255			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125			Bacteria	1MVSQ@1224,1RMWK@1236,3XN61@561,COG1136@1,COG1136@2	NA|NA|NA	V	Part of the ABC transporter complex LolCDE involved in the translocation of
C1_02107	481805.EcolC_2485	1.1e-207	729.2	Escherichia	lolC	GO:0005575,GO:0005623,GO:0005886,GO:0008104,GO:0008150,GO:0016020,GO:0032991,GO:0033036,GO:0034613,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0070727,GO:0071944,GO:0072657,GO:0089705,GO:0098796,GO:0098797,GO:1990778		ko:K02004,ko:K09808	ko02010,map02010	M00255,M00258			ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.125			Bacteria	1MVV7@1224,1RMP9@1236,3XMQJ@561,COG4591@1,COG4591@2	NA|NA|NA	M	Part of an ATP-dependent transport system LolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and of LolA
C1_02108	316407.4062683	7.8e-186	656.4	Escherichia	ycfT	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1Q61M@1224,1RR84@1236,3XNED@561,COG4763@1,COG4763@2	NA|NA|NA	S	transferase activity, transferring acyl groups other than amino-acyl groups
C1_02109	481805.EcolC_2487	0.0	2299.2	Escherichia	mfd	GO:0000715,GO:0000716,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006283,GO:0006289,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031326,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0043175,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051276,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1903506,GO:2000112,GO:2001141		ko:K03723	ko03420,map03420				ko00000,ko00001,ko01000,ko03400				Bacteria	1MUXG@1224,1RNCU@1236,3XMAX@561,COG1197@1,COG1197@2	NA|NA|NA	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C1_02110	155864.EDL933_1691	1.8e-181	641.7	Escherichia	ycfS	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008234,GO:0008236,GO:0008238,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016746,GO:0016755,GO:0016787,GO:0016807,GO:0017171,GO:0018104,GO:0019538,GO:0030203,GO:0034645,GO:0042546,GO:0043164,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0070004,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071972,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576		ko:K16291,ko:K19234,ko:K19235,ko:K19236	ko01503,map01503				ko00000,ko00001,ko01002,ko01011				Bacteria	1MVYT@1224,1RMNC@1236,3XNS9@561,COG1376@1,COG1376@2,COG1388@1,COG1388@2	NA|NA|NA	M	Responsible, at least in part, for anchoring of the major outer membrane lipoprotein (Lpp, also known as the Braun lipoprotein) to the peptidoglycan via a meso-diaminopimelyl-L- Lys- bond on the terminal residue of Lpp
C1_02111	155864.EDL933_1690	7.1e-37	159.5	Escherichia	bhsA	GO:0005575,GO:0005623,GO:0008150,GO:0009279,GO:0010035,GO:0010038,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0042221,GO:0044462,GO:0044464,GO:0046688,GO:0050896,GO:0071944		ko:K12151					ko00000,ko02048				Bacteria	1MZS8@1224,1S94M@1236,2E4GN@1,32ZBU@2,3XQ2D@561	NA|NA|NA	M	Reduces the permeability of the outer membrane to copper
C1_02112	198214.SF1115	4.3e-129	467.2	Gammaproteobacteria	ycfQ	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010038,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042221,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046688,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K16137,ko:K19335,ko:K22041					ko00000,ko03000				Bacteria	1NCEF@1224,1RQ8N@1236,COG1309@1,COG1309@2	NA|NA|NA	K	Transcriptional regulator
C1_02113	198214.SF1114	1.7e-85	322.0	Gammaproteobacteria	ycfJ	GO:0008150,GO:0043900,GO:0050789,GO:0050794,GO:0065007,GO:1900190											Bacteria	1MVWD@1224,1RQR9@1236,COG3134@1,COG3134@2	NA|NA|NA	S	Outer Membrane Lipoprotein
C1_02114	316407.1651546	3e-248	864.0	Escherichia	ndh	GO:0000166,GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0019646,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0036094,GO:0042592,GO:0043167,GO:0043168,GO:0044237,GO:0044425,GO:0044464,GO:0045333,GO:0048037,GO:0048878,GO:0050136,GO:0050660,GO:0050662,GO:0050801,GO:0055065,GO:0055070,GO:0055076,GO:0055080,GO:0055114,GO:0065007,GO:0065008,GO:0071944,GO:0097159,GO:0098771,GO:0098796,GO:1901265,GO:1901363,GO:1902494	1.6.99.3	ko:K03885	ko00190,map00190				ko00000,ko00001,ko01000			iECIAI39_1322.ECIAI39_2051,iPC815.YPO1617	Bacteria	1MX96@1224,1RM9I@1236,3XP16@561,COG1252@1,COG1252@2	NA|NA|NA	C	NADH dehydrogenase
C1_02115	1440052.EAKF1_ch0323c	1.9e-103	381.7	Escherichia	ycfP	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K07000					ko00000				Bacteria	1NV1Y@1224,1RPQX@1236,3XM60@561,COG3150@1,COG3150@2	NA|NA|NA	S	Belongs to the UPF0227 family
C1_02116	481805.EcolC_2494	9.1e-192	676.0	Escherichia	nagZ	GO:0000270,GO:0003674,GO:0003824,GO:0004553,GO:0004563,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006807,GO:0008150,GO:0008152,GO:0009254,GO:0009273,GO:0009987,GO:0015929,GO:0016787,GO:0016798,GO:0030203,GO:0042546,GO:0043170,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901564	2.7.8.7,3.2.1.21,3.2.1.52	ko:K00997,ko:K01207,ko:K05349	ko00460,ko00500,ko00520,ko00531,ko00770,ko00940,ko01100,ko01110,ko01501,map00460,map00500,map00520,map00531,map00770,map00940,map01100,map01110,map01501	M00628	R00022,R00026,R01625,R02558,R02887,R02985,R03527,R04949,R04998,R05963,R07809,R07810,R10035,R10039,R10040,R10831	RC00002,RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko00002,ko01000		GH3	iSFV_1184.SFV_1127,iUMN146_1321.UM146_11790	Bacteria	1MVAJ@1224,1RMQF@1236,3XN5W@561,COG1472@1,COG1472@2	NA|NA|NA	M	Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides
C1_02117	155864.EDL933_1684	3.5e-162	577.4	Escherichia	thiK	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019165,GO:0044237	2.7.1.89	ko:K07251	ko00730,ko01100,map00730,map01100		R02134	RC00002,RC00017	ko00000,ko00001,ko01000			iE2348C_1286.E2348C_1198,iEC042_1314.EC042_1176,iECED1_1282.ECED1_1249,iECO111_1330.ECO111_1383,iECO26_1355.ECO26_1439,iECUMN_1333.ECUMN_1284	Bacteria	1MURU@1224,1RNUN@1236,3XMAG@561,COG0510@1,COG0510@2	NA|NA|NA	F	Catalyzes the phosphorylation of thiamine to thiamine phosphate
C1_02118	155864.EDL933_1683	2.7e-101	374.8	Escherichia	lpoB	GO:0000270,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0019899,GO:0030203,GO:0030234,GO:0030312,GO:0030313,GO:0031241,GO:0031975,GO:0034645,GO:0042546,GO:0043085,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044093,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044462,GO:0044464,GO:0050790,GO:0065007,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0098552,GO:0098772,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576		ko:K07337,ko:K21008	ko02025,map02025				ko00000,ko00001				Bacteria	1QFS9@1224,1RSK3@1236,3XP7D@561,COG3417@1,COG3417@2	NA|NA|NA	M	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
C1_02119	155864.EDL933_1682	4.5e-64	250.4	Escherichia	ycfL	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716											Bacteria	1RED7@1224,1S4SB@1236,3XPR8@561,COG5633@1,COG5633@2	NA|NA|NA	S	cellular response to DNA damage stimulus
C1_02120	155864.EDL933_1681	6.4e-60	236.5	Escherichia	hinT	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019478,GO:0019752,GO:0043436,GO:0043530,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046144,GO:0046395,GO:0046416,GO:0046436,GO:0055130,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606		ko:K02503					ko00000,ko04147				Bacteria	1RDCJ@1224,1S3QE@1236,3XPPK@561,COG0537@1,COG0537@2	NA|NA|NA	FG	Hydrolyzes purine nucleotide phosphoramidates, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate), guanosine 5'monophosphomorpholidate (GMP-morpholidate) and tryptamine 5'guanosine monophosphate (TpGd). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha- acetyl lysine methyl ester)) generated by lysine--tRNA ligase, and lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)). Is essential for the activity of the enzyme D- alanine dehydrogenase (DadA) and is required for E.coli to grow on D-alanine as a sole carbon source. Is also required for growth at high salt concentrations
C1_02121	316407.1651542	0.0	1477.2	Escherichia	fhuE	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944		ko:K16088					ko00000,ko02000	1.B.14.1.10,1.B.14.1.3,1.B.14.1.8		iSDY_1059.SDY_2048	Bacteria	1MW5E@1224,1RMBD@1236,3XM3J@561,COG4773@1,COG4773@2	NA|NA|NA	P	Outer-membrane receptor for Fe(III)-coprogen, Fe(III)-ferrioxamine B and Fe(III)-rhodotrulic acid
C1_02122	155864.EDL933_1678	1.6e-266	924.9	Escherichia	ptsG	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0008645,GO:0009401,GO:0015144,GO:0015749,GO:0016020,GO:0016021,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034219,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090564,GO:1904659	2.7.1.192,2.7.1.193,2.7.1.199,2.7.1.201,2.7.1.208	ko:K02749,ko:K02750,ko:K02752,ko:K02753,ko:K02778,ko:K02779,ko:K02790,ko:K02791,ko:K02802,ko:K02803,ko:K02804,ko:K02818,ko:K02819,ko:K11191,ko:K11192,ko:K20116,ko:K20117,ko:K20118	ko00010,ko00500,ko00520,ko02060,ko05111,map00010,map00500,map00520,map02060,map05111	M00265,M00266,M00267,M00268,M00270,M00272,M00303,M00809	R02738,R02780,R04111,R04394,R05132,R05199,R08559	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.1.1,4.A.1.1.10,4.A.1.1.13,4.A.1.1.14,4.A.1.1.15,4.A.1.1.16,4.A.1.1.2,4.A.1.1.3,4.A.1.1.4,4.A.1.1.5,4.A.1.1.7,4.A.1.1.8,4.A.1.1.9,4.A.1.2.13,4.A.1.2.3,4.A.1.2.4,4.A.1.2.7,4.A.1.2.8		iECABU_c1320.ECABU_c48060,iECIAI39_1322.ECIAI39_2574,iECIAI39_1322.ECIAI39_2901,iECNA114_1301.ECNA114_1668,iECP_1309.ECP_0691,iECSF_1327.ECSF_1482,ic_1306.c5339	Bacteria	1MY1V@1224,1RMYZ@1236,3XMP0@561,COG1263@1,COG1263@2,COG1264@1,COG1264@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II complex composed of PtsG and Crr is involved in glucose transport. Also functions as a chemoreceptor monitoring the environment for changes in sugar concentration
C1_02123	155864.EDL933_1677	6.7e-150	536.6	Escherichia	ycfH	GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575		ko:K03424					ko00000,ko01000				Bacteria	1MUC0@1224,1RP6E@1236,3XMJ2@561,COG0084@1,COG0084@2	NA|NA|NA	L	metal-dependent hydrolase YcfH
C1_02124	155864.EDL933_1676	2.3e-192	677.9	Escherichia	holB	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Bacteria	1MY1W@1224,1RNYA@1236,3XMF9@561,COG0470@1,COG0470@2	NA|NA|NA	L	Part of the beta sliding clamp loading complex, which hydrolyzes ATP to load the beta clamp onto primed DNA to form the DNA replication pre-initiation complex. DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The gamma complex (gamma(3),delta,delta') is thought to load beta dimers onto DNA by binding ATP which alters the complex's conformation so it can bind beta sliding clamp dimers and open them at one interface. Primed DNA is recognized, ATP is hydrolyzed releasing the gamma complex and closing the beta sliding clamp ring around the primed DNA
C1_02125	198214.SF1102	5.3e-113	413.7	Gammaproteobacteria	tmk	GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000			iECABU_c1320.ECABU_c13120,ic_1306.c1370	Bacteria	1MV9C@1224,1S26C@1236,COG0125@1,COG0125@2	NA|NA|NA	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C1_02126	362663.ECP_1089	3.4e-191	674.1	Escherichia	mltG	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006807,GO:0008150,GO:0008152,GO:0008932,GO:0008933,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0030203,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0042597,GO:0043170,GO:0044425,GO:0044459,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901564		ko:K07082					ko00000				Bacteria	1MUQF@1224,1RMWD@1236,3XP1G@561,COG1559@1,COG1559@2	NA|NA|NA	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C1_02127	469008.B21_01100	1.4e-150	538.9	Escherichia	pabC	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008696,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0019842,GO:0030170,GO:0034641,GO:0036094,GO:0042558,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0070279,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901564	2.6.1.42,4.1.3.38	ko:K00826,ko:K02619	ko00270,ko00280,ko00290,ko00770,ko00790,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map00790,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R05553,R10991	RC00006,RC00036,RC01843,RC02148	ko00000,ko00001,ko00002,ko01000,ko01007			iAPECO1_1312.APECO1_177,iE2348C_1286.E2348C_1188,iECED1_1282.ECED1_1239,iECNA114_1301.ECNA114_1153,iECOK1_1307.ECOK1_1203,iECS88_1305.ECS88_1110,iECSF_1327.ECSF_0995,iECUMN_1333.ECUMN_1273,iJN746.PP_1917,iPC815.YPO1603,iUMN146_1321.UM146_11845,iUTI89_1310.UTI89_C1222,ic_1306.c1366	Bacteria	1MZAK@1224,1RPPG@1236,3XMCE@561,COG0115@1,COG0115@2	NA|NA|NA	H	4-amino-4-deoxychorismate lyase
C1_02128	198214.SF1099	5.4e-231	806.6	Gammaproteobacteria	fabF	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0033817,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004			iAF1260.b1095,iAPECO1_1312.APECO1_176,iB21_1397.B21_01099,iBWG_1329.BWG_0943,iE2348C_1286.E2348C_1187,iEC042_1314.EC042_1165,iEC55989_1330.EC55989_1207,iECABU_c1320.ECABU_c13085,iECBD_1354.ECBD_2506,iECB_1328.ECB_01091,iECDH10B_1368.ECDH10B_1167,iECDH1ME8569_1439.ECDH1ME8569_1030,iECD_1391.ECD_01091,iECED1_1282.ECED1_1238,iECH74115_1262.ECH74115_1474,iECIAI1_1343.ECIAI1_1130,iECIAI39_1322.ECIAI39_2066,iECO103_1326.ECO103_1140,iECO111_1330.ECO111_1372,iECO26_1355.ECO26_1428,iECOK1_1307.ECOK1_1202,iECP_1309.ECP_1087,iECS88_1305.ECS88_1109,iECSE_1348.ECSE_1159,iECSF_1327.ECSF_0994,iECSP_1301.ECSP_1396,iECUMN_1333.ECUMN_1270,iECW_1372.ECW_m1203,iECs_1301.ECs1473,iEKO11_1354.EKO11_2739,iETEC_1333.ETEC_1160,iEcDH1_1363.EcDH1_2552,iEcE24377_1341.EcE24377A_1216,iEcSMS35_1347.EcSMS35_2032,iG2583_1286.G2583_1355,iJO1366.b1095,iJR904.b1095,iLF82_1304.LF82_0607,iNRG857_1313.NRG857_05280,iSF_1195.SF1099,iSFxv_1172.SFxv_1251,iS_1188.S1179,iUMN146_1321.UM146_11850,iWFL_1372.ECW_m1203,iY75_1357.Y75_RS05720,iZ_1308.Z1734,ic_1306.c1365	Bacteria	1MU1X@1224,1RMDE@1236,COG0304@1,COG0304@2	NA|NA|NA	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
C1_02129	1005994.GTGU_00900	2.2e-32	144.4	Gammaproteobacteria	acpP	GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0050896,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509		ko:K02078					ko00000,ko00001				Bacteria	1MZ4P@1224,1S8X4@1236,COG0236@1,COG0236@2	NA|NA|NA	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C1_02130	198214.SF1097	2.4e-125	454.9	Gammaproteobacteria													Bacteria	1MU6X@1224,1RMBB@1236,COG1028@1,COG1028@2	NA|NA|NA	IQ	reductase
C1_02131	199310.c1361	9.2e-167	592.8	Escherichia	fabD	GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004			iEcE24377_1341.EcE24377A_1213,iJN746.PP_1913,iPC815.YPO1598	Bacteria	1MV6N@1224,1RNH3@1236,3XN0C@561,COG0331@1,COG0331@2	NA|NA|NA	I	malonyl CoA-acyl carrier protein transacylase
C1_02132	155864.EDL933_1668	1.1e-175	622.5	Escherichia	fabH	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0033818,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004			iAF1260.b1091,iAPECO1_1312.APECO1_172,iBWG_1329.BWG_0939,iE2348C_1286.E2348C_1183,iEC55989_1330.EC55989_1203,iECABU_c1320.ECABU_c13040,iECDH10B_1368.ECDH10B_1163,iECDH1ME8569_1439.ECDH1ME8569_1026,iECED1_1282.ECED1_1234,iECH74115_1262.ECH74115_1470,iECIAI39_1322.ECIAI39_2070,iECO103_1326.ECO103_1136,iECO111_1330.ECO111_1368,iECO26_1355.ECO26_1424,iECOK1_1307.ECOK1_1198,iECP_1309.ECP_1083,iECS88_1305.ECS88_1105,iECSP_1301.ECSP_1392,iECW_1372.ECW_m1199,iECs_1301.ECs1469,iEKO11_1354.EKO11_2743,iETEC_1333.ETEC_1156,iEcDH1_1363.EcDH1_2556,iEcE24377_1341.EcE24377A_1212,iEcSMS35_1347.EcSMS35_2036,iG2583_1286.G2583_1351,iJO1366.b1091,iJR904.b1091,iLF82_1304.LF82_0609,iNRG857_1313.NRG857_05260,iSSON_1240.SSON_1111,iSbBS512_1146.SbBS512_E2233,iUMN146_1321.UM146_11870,iUMNK88_1353.UMNK88_1361,iUTI89_1310.UTI89_C1216,iWFL_1372.ECW_m1199,iY75_1357.Y75_RS05700,iZ_1308.Z1730,ic_1306.c1360	Bacteria	1MU9N@1224,1RNIR@1236,3XMAF@561,COG0332@1,COG0332@2	NA|NA|NA	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C1_02133	155864.EDL933_1667	4e-187	660.6	Escherichia	plsX	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0071704,GO:0090407,GO:1901576	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004			iEcDH1_1363.EcDH1_2557,iSFxv_1172.SFxv_1246,iY75_1357.Y75_RS05695	Bacteria	1MVM3@1224,1RM7R@1236,3XMRS@561,COG0416@1,COG0416@2	NA|NA|NA	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
C1_02134	1114922.CIFAM_06_03660	7.9e-24	115.5	Citrobacter	rpmF	GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904		ko:K02911	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011,ko03029				Bacteria	1N6RF@1224,1SC9G@1236,3WYWW@544,COG0333@1,COG0333@2	NA|NA|NA	J	Ribosomal L32p protein family
C1_02135	155864.EDL933_1665	4.1e-92	344.0	Escherichia	yceD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464		ko:K07040					ko00000				Bacteria	1PGKW@1224,1RRK3@1236,3XMXZ@561,COG1399@1,COG1399@2	NA|NA|NA	S	Plays a role in synthesis, processing and or stability of 23S rRNA
C1_02136	198214.SF1091	3.9e-113	414.1	Gammaproteobacteria	maf	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030312,GO:0044464,GO:0047429,GO:0071944	1.1.1.25,2.1.1.190	ko:K00014,ko:K03215,ko:K06287	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000,ko03009				Bacteria	1RDA9@1224,1S3TQ@1236,COG0424@1,COG0424@2	NA|NA|NA	D	Maf-like protein
C1_02137	198214.SF1090	1.2e-174	619.0	Gammaproteobacteria	rluC	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.24	ko:K06179					ko00000,ko01000,ko03009				Bacteria	1MVDX@1224,1RPAN@1236,COG0564@1,COG0564@2	NA|NA|NA	J	Responsible for synthesis of pseudouridine from uracil
C1_02138	481805.EcolC_2516	0.0	1703.7	Escherichia	rne	GO:0000287,GO:0000966,GO:0000967,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008312,GO:0008995,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016072,GO:0016787,GO:0016788,GO:0017151,GO:0019222,GO:0019439,GO:0019899,GO:0022607,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034655,GO:0034660,GO:0042254,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043462,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0046872,GO:0048519,GO:0050789,GO:0050790,GO:0051095,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051336,GO:0060255,GO:0065003,GO:0065007,GO:0065009,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902280	3.1.26.12	ko:K08300	ko03018,map03018	M00394			ko00000,ko00001,ko00002,ko01000,ko03009,ko03019				Bacteria	1MV65@1224,1RMDS@1236,3XMU0@561,COG1530@1,COG1530@2	NA|NA|NA	J	Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs
C1_02139	481805.EcolC_2517	3.2e-167	594.3	Escherichia	flgL	GO:0005575,GO:0005576,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464		ko:K02397	ko02040,map02040				ko00000,ko00001,ko02035				Bacteria	1PJUJ@1224,1RPNR@1236,3XN6Z@561,COG1344@1,COG1344@2	NA|NA|NA	N	Flagellar hook-associated protein 3
C1_02140	316407.1651528	1.1e-295	1021.9	Escherichia	flgK	GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0030030,GO:0030031,GO:0044085,GO:0044780,GO:0044781,GO:0070925,GO:0071840		ko:K02396	ko02040,map02040				ko00000,ko00001,ko02035				Bacteria	1MV2M@1224,1RMEA@1236,3XPGC@561,COG1256@1,COG1256@2	NA|NA|NA	N	flagellar hook-associated protein
C1_02141	316407.4062659	2.1e-171	608.2	Escherichia	flgJ	GO:0001539,GO:0003674,GO:0005198,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588	3.5.1.28	ko:K01448,ko:K02395	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02035,ko03036				Bacteria	1MX2W@1224,1RPGY@1236,3XMH9@561,COG1705@1,COG1705@2,COG3951@1,COG3951@2	NA|NA|NA	MNOU	Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space
C1_02142	198214.SF1084	1.1e-192	679.1	Gammaproteobacteria	flgI	GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0006950,GO:0006974,GO:0008150,GO:0009288,GO:0009425,GO:0009987,GO:0033554,GO:0040011,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0071973,GO:0097588		ko:K02394	ko02040,map02040				ko00000,ko00001,ko02035				Bacteria	1MVKW@1224,1RMRB@1236,COG1706@1,COG1706@2	NA|NA|NA	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C1_02143	155864.EDL933_1656	2.4e-127	461.5	Escherichia	flgH	GO:0006950,GO:0006970,GO:0008150,GO:0009628,GO:0050896		ko:K02393	ko02040,map02040				ko00000,ko00001,ko02035				Bacteria	1RDEY@1224,1S3XK@1236,3XM5H@561,COG2063@1,COG2063@2	NA|NA|NA	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C1_02144	155864.EDL933_1655	1e-139	502.7	Escherichia	flgG	GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009279,GO:0009288,GO:0009424,GO:0009425,GO:0009987,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044462,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071944,GO:0071973,GO:0071978,GO:0097588		ko:K02392	ko02040,map02040				ko00000,ko00001,ko02035				Bacteria	1MVMA@1224,1RMJ2@1236,3XNKZ@561,COG4786@1,COG4786@2	NA|NA|NA	N	Belongs to the flagella basal body rod proteins family
C1_02145	481805.EcolC_2523	3.5e-132	477.6	Escherichia	flgF	GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009424,GO:0009425,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588		ko:K02391	ko02040,map02040				ko00000,ko00001,ko02035				Bacteria	1NZWQ@1224,1RNVX@1236,3XM3P@561,COG4787@1,COG4787@2	NA|NA|NA	N	bacterial-type flagellum-dependent swarming motility
C1_02146	469008.B21_01080	8.7e-218	762.7	Escherichia	flgE	GO:0001539,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006928,GO:0008150,GO:0009288,GO:0009424,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044424,GO:0044444,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588		ko:K02390	ko02040,map02040				ko00000,ko00001,ko02035				Bacteria	1MU5J@1224,1RMWX@1236,3XNMQ@561,COG1749@1,COG1749@2	NA|NA|NA	N	bacterial-type flagellum-dependent swarming motility
C1_02147	316407.4062652	5e-117	427.2	Escherichia	flgD	GO:0001539,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006928,GO:0008150,GO:0009288,GO:0009424,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044424,GO:0044444,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588		ko:K02389,ko:K02390	ko02040,map02040				ko00000,ko00001,ko02035				Bacteria	1MXCG@1224,1RPZI@1236,3XNA0@561,COG1843@1,COG1843@2	NA|NA|NA	N	Required for flagellar hook formation. May act as a scaffolding protein
C1_02148	155864.EDL933_1651	1.5e-65	255.4	Escherichia	flgC	GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009424,GO:0009425,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588		ko:K02388	ko02040,map02040				ko00000,ko00001,ko02035				Bacteria	1RHI3@1224,1S653@1236,3XPIV@561,COG1558@1,COG1558@2	NA|NA|NA	N	Belongs to the flagella basal body rod proteins family
C1_02149	198214.SF1079	1.1e-68	265.8	Gammaproteobacteria	flgB	GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009424,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588		ko:K02387	ko02040,map02040				ko00000,ko00001,ko02035				Bacteria	1MZ8P@1224,1S9DS@1236,COG1815@1,COG1815@2	NA|NA|NA	N	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body
C1_02150	198214.SF1078	9.2e-113	412.9	Gammaproteobacteria	flgA	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588		ko:K02279,ko:K02386	ko02040,map02040				ko00000,ko00001,ko02035,ko02044				Bacteria	1NY6E@1224,1RMY1@1236,COG1261@1,COG1261@2	NA|NA|NA	N	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
C1_02151	198214.SF1077	1.1e-41	175.6	Gammaproteobacteria	flgM	GO:0000988,GO:0000989,GO:0003674,GO:0008150,GO:0009889,GO:0009892,GO:0010556,GO:0010605,GO:0016989,GO:0019219,GO:0019222,GO:0030162,GO:0031323,GO:0031324,GO:0031326,GO:0032268,GO:0032269,GO:0045861,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141		ko:K02398	ko02020,ko02025,ko02026,ko02040,map02020,map02025,map02026,map02040				ko00000,ko00001,ko02035				Bacteria	1MZI7@1224,1S8UX@1236,COG2747@1,COG2747@2	NA|NA|NA	N	negative regulator of flagellin synthesis
C1_02152	316407.1651525	1.4e-69	268.9	Escherichia	flgN			ko:K02399	ko02040,map02040				ko00000,ko00001,ko02035				Bacteria	1MZUY@1224,1SAU2@1236,3XPTP@561,COG3418@1,COG3418@2	NA|NA|NA	N	Flagella synthesis protein FlgN
C1_02153	198214.SF1075	2.9e-274	950.7	Gammaproteobacteria	murJ	GO:0000270,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0006810,GO:0006869,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0010876,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0030203,GO:0031224,GO:0031226,GO:0033036,GO:0034203,GO:0034204,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046836,GO:0051179,GO:0051234,GO:0055085,GO:0061024,GO:0065007,GO:0065008,GO:0070589,GO:0071554,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0097035,GO:1901135,GO:1901137,GO:1901264,GO:1901505,GO:1901564,GO:1901566,GO:1901576		ko:K03980					ko00000,ko01011,ko02000	2.A.66.4		iECO103_1326.ECO103_1114	Bacteria	1MUH0@1224,1RMXX@1236,COG0728@1,COG0728@2	NA|NA|NA	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane
C1_02154	316407.4062647	1.4e-175	622.1	Escherichia	mviM		1.1.1.18,1.1.1.369	ko:K00010,ko:K03810	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130		R01183,R09951	RC00182	ko00000,ko00001,ko01000				Bacteria	1MVCX@1224,1RP1P@1236,3XNYI@561,COG0673@1,COG0673@2	NA|NA|NA	S	oxidoreductase activity
C1_02155	481805.EcolC_2533	7.4e-115	419.9	Escherichia	yceH	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K03810,ko:K09915					ko00000				Bacteria	1RA13@1224,1RQUQ@1236,3XMG5@561,COG3132@1,COG3132@2	NA|NA|NA	S	Belongs to the UPF0502 family
C1_02156	1440052.EAKF1_ch0363c	8.7e-115	419.5	Escherichia	rimJ	GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008999,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0051604,GO:0071704,GO:1901564	2.3.1.128	ko:K03790					ko00000,ko01000,ko03009				Bacteria	1MVG4@1224,1RQPX@1236,3XN9M@561,COG1670@1,COG1670@2	NA|NA|NA	J	This enzyme acetylates the N-terminal alanine of ribosomal protein S5. Plays also a role in the temperature regulation of pap pilin transcription
C1_02157	199310.c1332	2.1e-224	784.6	Escherichia	mdtH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K06610,ko:K08162					ko00000,ko02000	2.A.1.1.27,2.A.1.2.21			Bacteria	1QS3U@1224,1RNJ6@1236,3XNR6@561,COG0477@1,COG0477@2	NA|NA|NA	EGP	Confers resistance to norfloxacin and enoxacin
C1_02158	155864.EDL933_1640	2.2e-119	434.9	Escherichia	grxB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0015036,GO:0015037,GO:0015038,GO:0016491,GO:0016667,GO:0044424,GO:0044444,GO:0044464,GO:0055114		ko:K03675					ko00000,ko03110			iAF1260.b1064,iAPECO1_1312.APECO1_146,iB21_1397.B21_01068,iBWG_1329.BWG_0912,iEC042_1314.EC042_1131,iEC55989_1330.EC55989_1177,iECABU_c1320.ECABU_c12780,iECBD_1354.ECBD_2536,iECB_1328.ECB_01060,iECDH1ME8569_1439.ECDH1ME8569_0999,iECD_1391.ECD_01060,iECED1_1282.ECED1_1208,iECH74115_1262.ECH74115_1443,iECIAI1_1343.ECIAI1_1099,iECIAI39_1322.ECIAI39_2099,iECNA114_1301.ECNA114_1122,iECOK1_1307.ECOK1_1172,iECP_1309.ECP_1056,iECS88_1305.ECS88_1078,iECSE_1348.ECSE_1127,iECSF_1327.ECSF_0963,iECSP_1301.ECSP_1365,iECUMN_1333.ECUMN_1238,iECW_1372.ECW_m1171,iECs_1301.ECs1442,iEKO11_1354.EKO11_2769,iETEC_1333.ETEC_1129,iEcDH1_1363.EcDH1_2582,iEcE24377_1341.EcE24377A_1187,iEcHS_1320.EcHS_A1187,iEcSMS35_1347.EcSMS35_2065,iEcolC_1368.EcolC_2536,iG2583_1286.G2583_1323,iJO1366.b1064,iLF82_1304.LF82_0927,iNRG857_1313.NRG857_05130,iSBO_1134.SBO_2000,iSSON_1240.SSON_1084,iSbBS512_1146.SbBS512_E2262,iUMN146_1321.UM146_12010,iUMNK88_1353.UMNK88_1331,iUTI89_1310.UTI89_C1189,iWFL_1372.ECW_m1171,iY75_1357.Y75_RS05565,iZ_1308.Z1701,ic_1306.c1331	Bacteria	1N9FA@1224,1RMFC@1236,3XN0S@561,COG2999@1,COG2999@2	NA|NA|NA	O	in a coupled system with glutathione reductase. Does not act as hydrogen donor for ribonucleotide reductase
C1_02159	198214.SF1069	2.1e-97	361.7	Gammaproteobacteria	yceB												Bacteria	1PWBU@1224,1RPR9@1236,2CFK9@1,2Z7KF@2	NA|NA|NA	S	Lipoprotein
C1_02160	316407.1651523	5.8e-202	709.9	Escherichia	pyrC	GO:0003674,GO:0003824,GO:0004151,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019637,GO:0019856,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000			iSBO_1134.SBO_2002,iYL1228.KPN_01074	Bacteria	1MUYP@1224,1RNEN@1236,3XNMF@561,COG0418@1,COG0418@2	NA|NA|NA	F	Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate
C1_02161	155864.EDL933_1637	3e-37	160.6	Escherichia	dinI	GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0019899,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496		ko:K12149					ko00000,ko03400				Bacteria	1N075@1224,1S8YE@1236,2DMSQ@1,32TF2@2,3XQ0R@561	NA|NA|NA	L	Involved in SOS regulation. Inhibits RecA by preventing RecA to bind ssDNA. Can displace ssDNA from RecA
C1_02162	155864.EDL933_1636	3.3e-42	177.2	Escherichia	bssS	GO:0008150,GO:0043900,GO:0050789,GO:0050794,GO:0065007,GO:1900190		ko:K12148					ko00000,ko02048				Bacteria	1MZNE@1224,1S8Z0@1236,2CFXH@1,32S2R@2,3XPYZ@561	NA|NA|NA	S	Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway
C1_02163	481805.EcolC_2541	1.9e-219	768.1	Escherichia	solA	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016647,GO:0033554,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050131,GO:0050660,GO:0050662,GO:0050896,GO:0051716,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.5.3.1	ko:K00301,ko:K02846	ko00260,ko01100,map00260,map01100		R00610	RC00060,RC00557	ko00000,ko00001,ko01000			iEC042_1314.EC042_1126	Bacteria	1MU7M@1224,1RS24@1236,3XM89@561,COG0665@1,COG0665@2	NA|NA|NA	E	Catalyzes the oxidative demethylation of N-methyl-L- tryptophan
C1_02164	316407.85674826	5.5e-10	68.9	Bacteria	yceO	GO:0008150,GO:0009268,GO:0009628,GO:0010447,GO:0050896											Bacteria	2EH0X@1,33ASZ@2	NA|NA|NA	S	response to acidic pH
C1_02165	155864.EDL933_1633	7.2e-106	389.8	Escherichia	yceJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K12262					ko00000				Bacteria	1MZ7X@1224,1S3RF@1236,3XPKM@561,COG3038@1,COG3038@2	NA|NA|NA	C	respiratory electron transport chain
C1_02166	155864.EDL933_1632	6.8e-104	383.3	Escherichia	yceI												Bacteria	1R9XD@1224,1S24R@1236,3XNV9@561,COG2353@1,COG2353@2	NA|NA|NA	S	YceI-like domain
C1_02167	198214.SF1062	9.6e-197	692.6	Gammaproteobacteria	yceA			ko:K07146					ko00000				Bacteria	1MUFV@1224,1RNNU@1236,COG1054@1,COG1054@2	NA|NA|NA	S	Belongs to the UPF0176 family
C1_02168	155864.EDL933_1630	1.2e-182	645.6	Escherichia	lpxL	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.3.1.241,2.3.1.242,2.3.1.243	ko:K02517,ko:K02560,ko:K12974	ko00540,ko01100,map00540,map01100	M00060	R05075,R05146,R10906	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005			iEC042_1314.EC042_2597,iECIAI39_1322.ECIAI39_1194,iSF_1195.SF1061,iS_1188.S1138,iYL1228.KPN_01068	Bacteria	1MVNI@1224,1RMZ5@1236,3XNHW@561,COG1560@1,COG1560@2	NA|NA|NA	M	Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (lauroyl)-lipid IV(A)
C1_02169	316407.4062627	4.5e-222	776.9	Escherichia	mdtG	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015893,GO:0016020,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944		ko:K05820,ko:K08161					ko00000,ko02000	2.A.1.2.20,2.A.1.27		iECIAI39_1322.ECIAI39_2737,iEcSMS35_1347.EcSMS35_2688	Bacteria	1MUBP@1224,1RNXS@1236,3XMU2@561,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
C1_02170	155864.EDL933_1628	1.5e-64	251.9	Escherichia	msyB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K12147					ko00000				Bacteria	1RI2H@1224,1S689@1236,291QA@1,2ZPAE@2,3XPRZ@561	NA|NA|NA	S	MsyB protein
C1_02171	155864.EDL933_1627	1.4e-36	158.3	Escherichia	yceK	GO:0005575,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0033554,GO:0044425,GO:0044462,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:0098552											Bacteria	1MZSU@1224,1S9EJ@1236,3XQ12@561,COG5645@1,COG5645@2	NA|NA|NA	S	cellular response to DNA damage stimulus
C1_02172	155864.EDL933_1625	0.0	1689.1	Escherichia	mdoH	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0005975,GO:0005976,GO:0006073,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009628,GO:0009987,GO:0016020,GO:0016021,GO:0016051,GO:0016740,GO:0016757,GO:0031224,GO:0031226,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051273,GO:0051274,GO:0071704,GO:0071944,GO:1901576		ko:K03669					ko00000,ko01000,ko01003,ko02000	4.D.3.1.1	GT2		Bacteria	1MVXZ@1224,1RMGX@1236,3XM8N@561,COG2943@1,COG2943@2	NA|NA|NA	M	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C1_02173	199310.c1313	6.6e-300	1035.8	Escherichia	mdoG	GO:0000271,GO:0005575,GO:0005623,GO:0005975,GO:0005976,GO:0006073,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009628,GO:0009987,GO:0016051,GO:0030288,GO:0030313,GO:0031975,GO:0033692,GO:0034637,GO:0034645,GO:0042597,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0050896,GO:0051273,GO:0051274,GO:0071704,GO:1901576		ko:K03670					ko00000				Bacteria	1MUNX@1224,1RMEB@1236,3XNPJ@561,COG3131@1,COG3131@2	NA|NA|NA	P	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C1_02174	198214.SF1043	2.3e-220	771.2	Gammaproteobacteria	mdoC	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0008150,GO:0008152,GO:0009311,GO:0016020,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0044238,GO:0044464,GO:0071704,GO:0071944		ko:K11941					ko00000,ko01000				Bacteria	1N4D5@1224,1RREK@1236,COG1835@1,COG1835@2	NA|NA|NA	I	Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane
C1_02175	198214.SF1042	1.2e-285	988.4	Gammaproteobacteria	clsC	GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008808,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0019637,GO:0030572,GO:0032048,GO:0032049,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:0090483,GO:1901576	2.7.8.8	ko:K00998,ko:K06131,ko:K06132	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800,R07390,R11062	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000			iECED1_1282.ECED1_0754,iECH74115_1262.ECH74115_3822,iECSP_1301.ECSP_3532,iSDY_1059.SDY_1307	Bacteria	1MUDJ@1224,1RMIF@1236,COG1502@1,COG1502@2	NA|NA|NA	I	COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes
C1_02176	155864.EDL933_1620	1.3e-93	349.0	Escherichia	ymdB	GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005515,GO:0008150,GO:0008428,GO:0009892,GO:0010605,GO:0016787,GO:0019213,GO:0019219,GO:0019222,GO:0019899,GO:0030234,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0043086,GO:0043900,GO:0044092,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060698,GO:0060699,GO:0060700,GO:0060701,GO:0060702,GO:0061463,GO:0065007,GO:0065009,GO:0080090,GO:0098772,GO:1900190,GO:1900231											Bacteria	1RCWP@1224,1S3WJ@1236,3XMM8@561,COG2110@1,COG2110@2	NA|NA|NA	S	Deacetylates O-acetyl-ADP ribose. Down-regulates ribonuclease 3 (RNase III) activity. Acts by interacting directly with the region of the ribonuclease that is required for dimerization activation
C1_02177	155864.EDL933_1619	1.2e-49	202.2	Escherichia	ymdA												Bacteria	1QSMU@1224,1RW4W@1236,2DK8X@1,308WD@2,3XQ21@561	NA|NA|NA		
C1_02178	481805.EcolC_2556	2.3e-51	208.0	Escherichia	csgC			ko:K04336	ko02026,map02026				ko00000,ko00001,ko02044				Bacteria	1N2IV@1224,1S8D1@1236,2CHEZ@1,32UJP@2,3XQ36@561	NA|NA|NA	M	Curli assembly protein
C1_02179	316407.1651511	2.5e-16	92.0	Escherichia	csgA	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006807,GO:0007155,GO:0008150,GO:0008152,GO:0009289,GO:0009987,GO:0016043,GO:0019538,GO:0022610,GO:0042710,GO:0042802,GO:0042995,GO:0043170,GO:0044010,GO:0044238,GO:0044464,GO:0044764,GO:0051704,GO:0071704,GO:0071840,GO:0097435,GO:1901564,GO:1990000		ko:K04334	ko02026,map02026				ko00000,ko00001,ko02044				Bacteria	1RECY@1224,1S5Q8@1236,29Z81@1,30M63@2,3XPAD@561	NA|NA|NA	S	Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin
C1_02180	155864.EDL933_1616	1.1e-27	129.8	Gammaproteobacteria	csgB	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006807,GO:0007155,GO:0008150,GO:0008152,GO:0009279,GO:0009289,GO:0009987,GO:0016020,GO:0016043,GO:0019538,GO:0019867,GO:0022610,GO:0030312,GO:0030313,GO:0031975,GO:0042710,GO:0042802,GO:0042995,GO:0043170,GO:0044010,GO:0044238,GO:0044462,GO:0044464,GO:0044764,GO:0051704,GO:0071704,GO:0071840,GO:0071944,GO:0097435,GO:1901564,GO:1990000		ko:K04335	ko02026,map02026				ko00000,ko00001,ko02044				Bacteria	1NGYJ@1224,1SH6W@1236,2DRE1@1,33BC9@2	NA|NA|NA	S	PFAM Curlin associated repeat
C1_02181	155864.EDL933_1614	4.2e-118	430.6	Escherichia	csgD	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031334,GO:0032991,GO:0032993,GO:0043254,GO:0043565,GO:0043900,GO:0044087,GO:0044089,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1900190,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000144,GO:2001141		ko:K04333,ko:K07684	ko02020,ko02026,map02020,map02026	M00471			ko00000,ko00001,ko00002,ko02022,ko03000				Bacteria	1MXI3@1224,1RNEY@1236,3XMP9@561,COG2197@1,COG2197@2	NA|NA|NA	K	necessary for transcription of the csgBAC ymdA operon. Plays a positive role in biofilm formation. May have the capability to respond to starvation and or high cell density by activating csgBA transcription. Low-level constitutive expression confers an adherent curli fimbriae-expressing phenotype, up- regulates 10 genes and down-regulates 14 others
C1_02182	155864.EDL933_1613	4.8e-69	266.9	Escherichia	csgE	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0019867,GO:0022610,GO:0030288,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0042597,GO:0042710,GO:0042802,GO:0042886,GO:0044010,GO:0044462,GO:0044464,GO:0044764,GO:0045184,GO:0051179,GO:0051234,GO:0051704,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944		ko:K04337					ko00000,ko02044				Bacteria	1N6U8@1224,1S46H@1236,2C2E6@1,2ZPXX@2,3XPJH@561	NA|NA|NA	S	May be involved in the biogenesis of curli organelles
C1_02183	199310.c1300	1.9e-71	275.0	Escherichia	csgF	GO:0005575,GO:0005623,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0022610,GO:0030312,GO:0030313,GO:0031975,GO:0042710,GO:0044010,GO:0044462,GO:0044464,GO:0044764,GO:0051704,GO:0071944		ko:K04338					ko00000,ko02044				Bacteria	1N4PQ@1224,1SBR1@1236,2DEP1@1,32U3R@2,3XPNS@561	NA|NA|NA	S	May be involved in the biogenesis of curli organelles
C1_02184	155864.EDL933_1611	2.8e-151	541.2	Escherichia	csgG	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0019867,GO:0022610,GO:0030288,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0033036,GO:0042597,GO:0042710,GO:0042802,GO:0042886,GO:0044010,GO:0044425,GO:0044462,GO:0044464,GO:0044764,GO:0045184,GO:0051179,GO:0051234,GO:0051704,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098552		ko:K06214					ko00000,ko02044				Bacteria	1MVZM@1224,1RQ5F@1236,3XNNF@561,COG1462@1,COG1462@2	NA|NA|NA	M	Curli production assembly transport component CsgG
C1_02185	198214.SF1030	7.3e-89	333.2	Gammaproteobacteria	ycdZ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1RA69@1224,1S1YX@1236,28NYX@1,2ZBVY@2	NA|NA|NA	S	Protein of unknown function (DUF1097)
C1_02186	469008.B21_01039	4.7e-102	377.1	Escherichia	ycdY	GO:0001539,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006928,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0040011,GO:0044424,GO:0044444,GO:0044464,GO:0048870,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0071973,GO:0071978,GO:0097588											Bacteria	1Q3A7@1224,1RP51@1236,3XMDU@561,COG3381@1,COG3381@2	NA|NA|NA	S	Acts as a chaperone that increases YcdX activity, maybe by facilitating the correct insertion of the zinc ions into the catalytic site of YcdX. Involved in the swarming motility process
C1_02187	155864.EDL933_1607	1.3e-139	502.3	Escherichia	ycdX	GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006928,GO:0008150,GO:0008270,GO:0009987,GO:0016787,GO:0016788,GO:0040011,GO:0042578,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588		ko:K04477					ko00000				Bacteria	1MYXV@1224,1RRE9@1236,3XNRR@561,COG1387@1,COG1387@2	NA|NA|NA	E	Belongs to the PHP family
C1_02188	316407.4062597	2.3e-181	641.3	Escherichia	ghrA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0016618,GO:0030267,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.1.1.79,1.1.1.81	ko:K12972	ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00260,map00620,map00630,map01100,map01110,map01120		R00465,R01388,R01392,R02527	RC00031,RC00042,RC00670	ko00000,ko00001,ko01000			iECOK1_1307.ECOK1_1138,iECS88_1305.ECS88_1044,iUMN146_1321.UM146_12160	Bacteria	1MW1U@1224,1RRQE@1236,3XNVJ@561,COG0111@1,COG0111@2	NA|NA|NA	EH	Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively
C1_02190	316407.4062596	7.2e-178	629.8	Gammaproteobacteria	ycdU	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1R77S@1224,1S0M0@1236,28KHX@1,2ZA3B@2	NA|NA|NA		
C1_02191	155864.EDL933_1479	1.6e-85	322.0	Gammaproteobacteria	fabD		2.3.1.39	ko:K00645,ko:K15327,ko:K15329,ko:K15355,ko:K15469	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008			iEcE24377_1341.EcE24377A_1213	Bacteria	1NSQJ@1224,1SM9U@1236,COG0331@1,COG0331@2	NA|NA|NA	I	Acyl transferase domain
C1_02192	1440052.EAKF1_ch3017c	4.5e-43	180.3	Escherichia		GO:0005575,GO:0005623,GO:0008150,GO:0009279,GO:0009405,GO:0016020,GO:0019867,GO:0030260,GO:0030312,GO:0030313,GO:0031975,GO:0044403,GO:0044409,GO:0044419,GO:0044462,GO:0044464,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0071944		ko:K07483					ko00000				Bacteria	1RHBZ@1224,1S69Y@1236,3XR2P@561,COG2963@1,COG2963@2	NA|NA|NA	L	transposase activity
C1_02193	316407.1736794	7.5e-171	606.3	Gammaproteobacteria		GO:0008150,GO:0009987,GO:0032196		ko:K07497					ko00000				Bacteria	1MVXQ@1224,1RR4F@1236,COG2801@1,COG2801@2	NA|NA|NA	L	COG2801 Transposase and inactivated derivatives
C1_02194	469008.B21_01034	7.9e-252	875.9	Escherichia	ycdT	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0032879,GO:0042710,GO:0044010,GO:0044464,GO:0044764,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051270,GO:0051271,GO:0051704,GO:0052621,GO:0065007,GO:0071944,GO:0090605,GO:0090609											Bacteria	1MZV7@1224,1SC2U@1236,3XRI4@561,COG2199@1,COG3706@2	NA|NA|NA	T	swimming returns to normal when residues 359-360 are both mutated to Ala. Overexpression also leads to a 20-fold increase in c-di-GMP levels in vivo. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria
C1_02195	155864.EDL933_1451	0.0	1643.6	Escherichia													Bacteria	1RA3P@1224,1RY13@1236,3XNBM@561,COG0457@1,COG0457@2	NA|NA|NA	S	Exports the biofilm adhesin polysaccharide poly-beta- 1,6-N-acetyl-D-glucosamine (PGA) across the outer membrane. The PGA transported seems to be partially N-deacetylated since N- deacetylation of PGA by PgaB is needed for PGA export through the PgaA porin
C1_02196	316407.85674817	0.0	1365.9	Escherichia	pgaB	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016787,GO:0016810,GO:0043170,GO:0043412,GO:0071704,GO:0098732		ko:K11931,ko:K21478	ko02026,map02026		R03096	RC00010	ko00000,ko00001,ko01000				Bacteria	1MWR2@1224,1RP7J@1236,3XN4N@561,COG0726@1,COG0726@2,COG1649@1,COG1649@2	NA|NA|NA	M	Catalyzes the N-deacetylation of poly-beta-1,6-N-acetyl- D-glucosamine (PGA), a biofilm adhesin polysaccharide. N- deacetylation promotes PGA export through the PgaA porin
C1_02197	316407.4062586	5.7e-255	886.3	Escherichia	pgaC	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0007155,GO:0008150,GO:0008194,GO:0008375,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0022610,GO:0031589,GO:0042710,GO:0043708,GO:0044464,GO:0044764,GO:0051704,GO:0071944,GO:0090605		ko:K11936	ko02026,map02026				ko00000,ko00001,ko01000,ko01003,ko02000	4.D.1.1.2,4.D.1.1.3	GT2		Bacteria	1MXG7@1224,1RMS4@1236,3XQBS@561,COG1215@1,COG1215@2	NA|NA|NA	M	N-acetylglucosaminyltransferase that catalyzes the polymerization of single monomer units of UDP-N- acetylglucosamine to produce the linear homopolymer poly-beta-1,6- N-acetyl-D-glucosamine (PGA), a biofilm adhesin polysaccharide
C1_02198	316407.4062585	1.3e-67	262.3	Escherichia	pgaD	GO:0005575,GO:0005623,GO:0005886,GO:0007155,GO:0008150,GO:0009987,GO:0016020,GO:0022610,GO:0031589,GO:0042710,GO:0043708,GO:0044464,GO:0044764,GO:0051704,GO:0071944,GO:0090605		ko:K11937	ko02026,map02026				ko00000,ko00001				Bacteria	1NC08@1224,1SECV@1236,2EENA@1,338G7@2,3XR68@561	NA|NA|NA	S	PgaD-like protein
C1_02199	155864.EDL933_1447	5.1e-142	510.4	Escherichia	phoH	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K06217					ko00000				Bacteria	1PNF2@1224,1RNZ7@1236,3XMBE@561,COG1702@1,COG1702@2	NA|NA|NA	T	Phosphate starvation-inducible protein
C1_02200	500640.CIT292_07805	1.1e-17	95.9	Citrobacter													Bacteria	1QN9V@1224,1TKT5@1236,2AYJX@1,31QQ5@2,3WYYC@544	NA|NA|NA		
C1_02201	199310.c1157	7.9e-246	855.9	Escherichia	efeB			ko:K16301					ko00000,ko01000,ko02000	2.A.108.2.3			Bacteria	1MUEE@1224,1RNXN@1236,3XMXM@561,COG2837@1,COG2837@2	NA|NA|NA	P	Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact
C1_02202	155864.EDL933_1444	7.1e-206	723.0	Escherichia	efeO	GO:0000041,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006826,GO:0006950,GO:0006979,GO:0008150,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009636,GO:0015684,GO:0016020,GO:0030001,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0044464,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0070838,GO:0071944,GO:0072511		ko:K07224					ko00000,ko02000	2.A.108.2.3			Bacteria	1MWFR@1224,1RNWE@1236,3XMU6@561,COG2822@1,COG2822@2	NA|NA|NA	P	Involved in Fe(2 ) uptake. Could be an iron-binding and or electron-transfer component
C1_02203	155864.EDL933_1443	3.1e-150	537.7	Escherichia	efeU	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K07243					ko00000,ko02000	2.A.108.1,2.A.108.2			Bacteria	1MXHM@1224,1RMWB@1236,3XN4Y@561,COG0672@1,COG0672@2	NA|NA|NA	P	iron ion transmembrane transporter activity
C1_02204	469008.B21_01025	9e-281	972.2	Escherichia	putP	GO:0003333,GO:0003674,GO:0005215,GO:0005283,GO:0005298,GO:0005342,GO:0005343,GO:0005416,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006820,GO:0006865,GO:0006869,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0010876,GO:0015075,GO:0015077,GO:0015081,GO:0015171,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015672,GO:0015711,GO:0015718,GO:0015804,GO:0015824,GO:0015849,GO:0015908,GO:0015912,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0033036,GO:0034220,GO:0035725,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:1903825,GO:1905039		ko:K11928					ko00000,ko02000	2.A.21.2		iSbBS512_1146.SbBS512_E2302	Bacteria	1MUBI@1224,1RMXU@1236,3XNW6@561,COG0591@1,COG0591@2	NA|NA|NA	P	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1_02205	481805.EcolC_2581	0.0	2572.7	Escherichia	putA	GO:0000166,GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0003824,GO:0003842,GO:0004657,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006355,GO:0006520,GO:0006536,GO:0006560,GO:0006562,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009889,GO:0009890,GO:0009892,GO:0009898,GO:0009987,GO:0010133,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0016054,GO:0016491,GO:0016645,GO:0016646,GO:0019219,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0043565,GO:0043648,GO:0044212,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044425,GO:0044459,GO:0044464,GO:0045892,GO:0045934,GO:0046395,GO:0046483,GO:0046700,GO:0048037,GO:0048519,GO:0048523,GO:0050660,GO:0050662,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0055114,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:0098552,GO:0098562,GO:0140110,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141	1.2.1.88,1.3.8.7,1.5.5.2	ko:K00249,ko:K00294,ko:K13821	ko00071,ko00250,ko00280,ko00330,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00250,map00280,map00330,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00245,R00707,R00708,R00924,R01175,R01253,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04444,R04445,R04751,R04754,R05051	RC00052,RC00068,RC00076,RC00080,RC00083,RC00095,RC00148,RC00216,RC00242,RC00246,RC00255	ko00000,ko00001,ko00002,ko01000,ko03000			iPC815.YPO1851,iSbBS512_1146.SbBS512_E2304	Bacteria	1MV93@1224,1RN48@1236,3XMSS@561,COG0506@1,COG0506@2,COG3905@1,COG3905@2,COG4230@1,COG4230@2	NA|NA|NA	K	Oxidizes proline to glutamate for use as a carbon and nitrogen source
C1_02206	198214.SF1016	3.4e-112	411.0	Gammaproteobacteria	rutR	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K09017					ko00000,ko03000				Bacteria	1ND64@1224,1RS7A@1236,COG1309@1,COG1309@2	NA|NA|NA	K	transcriptional regulator
C1_02207	155864.EDL933_1433	4.3e-208	730.3	Escherichia	rutA	GO:0003674,GO:0003824,GO:0004497,GO:0006139,GO:0006206,GO:0006208,GO:0006210,GO:0006212,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016491,GO:0017144,GO:0019740,GO:0019859,GO:0019860,GO:0034641,GO:0042737,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0046113,GO:0046483,GO:0046700,GO:0052614,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	1.14.99.46	ko:K09018	ko00240,ko01100,map00240,map01100		R09936	RC02732	ko00000,ko00001,ko01000			iEC55989_1330.EC55989_1123,iECUMN_1333.ECUMN_1195	Bacteria	1MXZH@1224,1RMB2@1236,3XQ6H@561,COG2141@1,COG2141@2	NA|NA|NA	F	Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate
C1_02208	481805.EcolC_2584	3.9e-130	470.7	Gammaproteobacteria	rutB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006208,GO:0006212,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0019740,GO:0019860,GO:0034641,GO:0042737,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	3.5.1.110	ko:K09020	ko00240,ko01100,map00240,map01100		R09947,R09980	RC02737,RC02738	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_102,iECED1_1282.ECED1_1167,iUTI89_1310.UTI89_C1074	Bacteria	1MV0W@1224,1RP6J@1236,COG1335@1,COG1335@2	NA|NA|NA	Q	In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2
C1_02209	199310.c1147	3.4e-67	260.8	Gammaproteobacteria	rutC	GO:0006139,GO:0006206,GO:0006208,GO:0006212,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0017144,GO:0019740,GO:0019860,GO:0034641,GO:0042737,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	3.5.99.10	ko:K09021,ko:K09022	ko00240,ko01100,map00240,map01100		R09982,R11098,R11099	RC02768,RC03275,RC03354	ko00000,ko00001,ko01000				Bacteria	1RD6W@1224,1S47V@1236,COG0251@1,COG0251@2	NA|NA|NA	J	May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation
C1_02210	481805.EcolC_2586	5.3e-147	526.9	Escherichia	rutD	GO:0006139,GO:0006206,GO:0006208,GO:0006212,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0017144,GO:0019740,GO:0019860,GO:0034641,GO:0042737,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575		ko:K09023	ko00240,ko01100,map00240,map01100		R09983	RC02769	ko00000,ko00001,ko01000			iEC55989_1330.EC55989_1120,iECO26_1355.ECO26_1247,iECUMN_1333.ECUMN_1192,iSF_1195.SF1012,iSFxv_1172.SFxv_1098,iSSON_1240.SSON_1027,iS_1188.S1082,ic_1306.c1146	Bacteria	1QVBR@1224,1T2BI@1236,3XRCZ@561,COG2021@1,COG2021@2	NA|NA|NA	F	May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in
C1_02211	155864.EDL933_1429	3.6e-108	397.5	Gammaproteobacteria	rutE	GO:0000166,GO:0003674,GO:0005488,GO:0006139,GO:0006206,GO:0006208,GO:0006212,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0010181,GO:0017144,GO:0019740,GO:0019860,GO:0032553,GO:0033554,GO:0034641,GO:0036094,GO:0042737,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0046113,GO:0046483,GO:0046700,GO:0048037,GO:0050662,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575		ko:K09019	ko00240,ko01100,map00240,map01100		R09289	RC00087	ko00000,ko00001,ko01000			iEC042_1314.EC042_1083,iECO103_1326.ECO103_1054,iG2583_1286.G2583_1241	Bacteria	1R9VX@1224,1RNQE@1236,COG0778@1,COG0778@2	NA|NA|NA	C	May reduce toxic product malonic semialdehyde to 3- hydroxypropionic acid, which is excreted
C1_02212	469008.B21_01017	1.8e-92	345.1	Gammaproteobacteria	rutF	GO:0003674,GO:0003824,GO:0006139,GO:0006206,GO:0006208,GO:0006212,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0017144,GO:0019740,GO:0019860,GO:0034641,GO:0042602,GO:0042737,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	1.5.1.36	ko:K00484,ko:K09024	ko00240,ko00350,ko00740,ko01100,ko01120,ko01220,map00240,map00350,map00740,map01100,map01120,map01220		R02698,R03299,R05705,R09748,R09750,R09936	RC00046,RC00126,RC02732	ko00000,ko00001,ko01000			iECH74115_1262.ECH74115_1244,iECSP_1301.ECSP_1176,iSDY_1059.SDY_0982,iSFV_1184.SFV_4374,iSF_1195.SF4373,iSFxv_1172.SFxv_4767,iS_1188.S4643,ic_1306.c1144	Bacteria	1NESS@1224,1S00E@1236,COG1853@1,COG1853@2	NA|NA|NA	C	Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway
C1_02213	316407.4062560	1.9e-234	818.1	Escherichia	rutG	GO:0003674,GO:0005215,GO:0005345,GO:0005350,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006206,GO:0006208,GO:0006212,GO:0006725,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006863,GO:0008150,GO:0008152,GO:0008324,GO:0008509,GO:0008514,GO:0009056,GO:0009112,GO:0009987,GO:0015075,GO:0015143,GO:0015205,GO:0015210,GO:0015238,GO:0015711,GO:0015747,GO:0015851,GO:0015855,GO:0015857,GO:0015893,GO:0016020,GO:0016021,GO:0017144,GO:0019860,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0034641,GO:0042221,GO:0042493,GO:0042737,GO:0042906,GO:0042907,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0072527,GO:0072529,GO:0072530,GO:0072531,GO:0098655,GO:0098656,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901702,GO:1903791,GO:1904082,GO:1904823		ko:K02824,ko:K03458,ko:K09016,ko:K16345,ko:K16346					ko00000,ko02000	2.A.40,2.A.40.1.1,2.A.40.1.2,2.A.40.1.3,2.A.40.4.2,2.A.40.4.3		iECO103_1326.ECO103_1052,iECUMN_1333.ECUMN_1189,iG2583_1286.G2583_3536,iSDY_1059.SDY_4086,iSFxv_1172.SFxv_2795,iS_1188.S2690	Bacteria	1MUN9@1224,1RRK5@1236,3XMK3@561,COG2233@1,COG2233@2	NA|NA|NA	F	permease
C1_02214	316407.85674813	2.5e-09	67.4	Escherichia	ymdF	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588		ko:K06884					ko00000				Bacteria	1N767@1224,1SCA5@1236,3XQ2R@561,COG3729@1,COG3729@2	NA|NA|NA	S	Stress-induced bacterial acidophilic repeat motif
C1_02215	198214.SF1008	5.8e-106	390.2	Gammaproteobacteria	wrbA	GO:0000166,GO:0003674,GO:0003824,GO:0003955,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0010181,GO:0016043,GO:0016491,GO:0016651,GO:0016655,GO:0022607,GO:0032553,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110		R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000				Bacteria	1MW7N@1224,1S23B@1236,COG0655@1,COG0655@2	NA|NA|NA	S	Belongs to the WrbA family
C1_02216	155864.EDL933_1343	4.5e-35	153.3	Escherichia	yccJ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Bacteria	1N16W@1224,1S9Z8@1236,2CE55@1,32RZ6@2,3XQ0S@561	NA|NA|NA	S	YccJ-like protein
C1_02217	481805.EcolC_2593	1.2e-238	832.0	Escherichia	agp	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008877,GO:0009056,GO:0009987,GO:0016052,GO:0016158,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019320,GO:0030288,GO:0030313,GO:0031975,GO:0042578,GO:0042597,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044464,GO:0046365,GO:0050308,GO:0071704,GO:1901575	3.1.3.10	ko:K01085	ko00010,ko01120,map00010,map01120		R00947	RC00078	ko00000,ko00001,ko01000			iECO111_1330.ECO111_1113,iECO26_1355.ECO26_1557	Bacteria	1NR0Z@1224,1RQ9G@1236,2DB79@1,2Z7K9@2,3XP1X@561	NA|NA|NA	S	glucose-1-phosphatase
C1_02218	469008.B21_01011	1.2e-36	158.7	Escherichia	yccE												Bacteria	1NRMN@1224,1SMDS@1236,2EWX4@1,33Q8G@2,3XR9Z@561	NA|NA|NA		
C1_02219	469008.B21_01011	5.7e-158	563.5	Escherichia	yccE												Bacteria	1NRMN@1224,1SMDS@1236,2EWX4@1,33Q8G@2,3XR9Z@561	NA|NA|NA		
C1_02220	198214.SF1004	1.7e-173	615.1	Gammaproteobacteria	cbpA	GO:0003674,GO:0003676,GO:0003677,GO:0003681,GO:0005488,GO:0097159,GO:1901363		ko:K03686,ko:K04082,ko:K05516					ko00000,ko03029,ko03036,ko03110				Bacteria	1MUZ4@1224,1RP09@1236,COG0484@1,COG0484@2	NA|NA|NA	O	displays overlapping activities with DnaJ, but functions under different conditions, probably acting as a molecular chaperone in an adaptive response to environmental stresses other than heat shock. Lacks autonomous chaperone activity
C1_02221	155864.EDL933_1337	1.1e-49	202.2	Escherichia	cbpM	GO:0003674,GO:0004857,GO:0008150,GO:0030234,GO:0043086,GO:0044092,GO:0050790,GO:0065007,GO:0065009,GO:0098772		ko:K18997					ko00000,ko03036				Bacteria	1N0AR@1224,1S9HZ@1236,3XPNV@561,COG0789@1,COG0789@2	NA|NA|NA	K	Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ
C1_02222	469008.B21_01008	2.8e-108	397.9	Escherichia	torD	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0019538,GO:0033218,GO:0042277,GO:0042802,GO:0043170,GO:0043546,GO:0044238,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0051604,GO:0071704,GO:0097159,GO:1901363,GO:1901564		ko:K03533	ko02020,map02020				ko00000,ko00001,ko02000	5.A.3.4			Bacteria	1RJ3Z@1224,1S31G@1236,3XNXG@561,COG3381@1,COG3381@2	NA|NA|NA	O	Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor
C1_02223	155864.EDL933_1335	0.0	1730.3	Escherichia	torA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006091,GO:0008150,GO:0008152,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0016661,GO:0016662,GO:0030151,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0045333,GO:0046872,GO:0046914,GO:0048037,GO:0050626,GO:0055114	1.7.2.3,1.8.5.3	ko:K07306,ko:K07811,ko:K07812,ko:K08351	ko00780,ko00920,ko01100,ko02020,map00780,map00920,map01100,map02020		R09501,R10127	RC02555,RC03056	ko00000,ko00001,ko01000,ko02000	5.A.3.3,5.A.3.4		iEC042_1314.EC042_1073,iEcHS_1320.EcHS_A3752,iEcolC_1368.EcolC_0165,iNRG857_1313.NRG857_09385	Bacteria	1NR6J@1224,1RMVE@1236,3XPC8@561,COG0243@1,COG0243@2	NA|NA|NA	C	an anaerobic reaction coupled to energy-yielding reactions
C1_02224	316407.1651488	1.8e-228	798.1	Escherichia	torC	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0020037,GO:0022900,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0071944,GO:0097159,GO:1901363,GO:1902494,GO:1990204		ko:K02569,ko:K03532,ko:K07821	ko02020,map02020				ko00000,ko00001,ko02000	5.A.3.4		iEC042_1314.EC042_1072,iEcolC_1368.EcolC_1448,iUTI89_1310.UTI89_C1060,ic_1306.c1132	Bacteria	1MWV2@1224,1RQ52@1236,3XQEX@561,COG3005@1,COG3005@2	NA|NA|NA	C	Part of the anaerobic respiratory chain of trimethylamine-N-oxide reductase TorA. Acts by transferring electrons from the membranous menaquinones to TorA. This transfer probably involves an electron transfer pathway from menaquinones to the N-terminal domain of TorC, then from the N-terminus to the C-terminus, and finally to TorA. TorC apocytochrome negatively autoregulates the torCAD operon probably by inhibiting the TorS kinase activity
C1_02225	199310.c1131	4.9e-125	453.8	Escherichia													Bacteria	1MWJG@1224,1RPU3@1236,3XM4X@561,COG0745@1,COG0745@2	NA|NA|NA	K	Member of the two-component regulatory system TorS TorR involved in the anaerobic utilization of trimethylamine-N-oxide (TMAO). Phosphorylated TorR activates the transcription of the torCAD operon by binding to four decameric boxes located in the torCAD promoter. Box1, 2 and 4 contain the DNA sequence 5'- CTGTTCATAT-3' and box3 contains the DNA sequence 5'-CCGTTCATCC-3'. Phosphorylated as well as unphosphorylated TorR negatively regulates its own expression by binding to box1 and 2
C1_02226	362663.ECP_0992	1.9e-189	668.3	Escherichia	torT	GO:0005575,GO:0005623,GO:0042597,GO:0044464		ko:K11930					ko00000				Bacteria	1MXQN@1224,1S0HG@1236,3XPG5@561,COG1879@1,COG1879@2	NA|NA|NA	G	inducer it probably interacts with TorS and allows it to play a role in the induction of the torCAD operon for trimethylamine N-oxide reductase
C1_02227	481805.EcolC_2602	0.0	1674.8	Escherichia	torS	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0010033,GO:0015980,GO:0016020,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0016853,GO:0016866,GO:0016868,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0042221,GO:0042578,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045333,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0070887,GO:0071310,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.7.13.3	ko:K03407,ko:K07647,ko:K14978	ko02020,ko02030,map02020,map02030	M00455,M00506,M00663			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035				Bacteria	1NRP8@1224,1SKTW@1236,3XMSI@561,COG0642@1,COG0784@1,COG0784@2,COG2198@1,COG2198@2,COG2205@2	NA|NA|NA	T	PhoQ Sensor
C1_02228	469008.B21_01002	7.5e-205	719.5	Escherichia	yccM	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1MY5M@1224,1RNSU@1236,3XP2W@561,COG0348@1,COG0348@2	NA|NA|NA	C	4 iron, 4 sulfur cluster binding
C1_02229	199310.c1125	1.6e-21	107.8	Escherichia	gnsA	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0042802,GO:0044424,GO:0044444,GO:0044464											Bacteria	1NEUJ@1224,1SFD3@1236,2BVP3@1,332DR@2,3XQ2P@561	NA|NA|NA	S	Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation
C1_02230	155864.EDL933_1327	2.3e-33	147.5	Escherichia	cspG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006950,GO:0008150,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141		ko:K03704					ko00000,ko03000			iECW_1372.ECW_m0678,iWFL_1372.ECW_m0678	Bacteria	1N6Q5@1224,1SCA7@1236,3XQ0H@561,COG1278@1,COG1278@2	NA|NA|NA	K	nucleic acid-templated transcription
C1_02231	155864.EDL933_1326	5.7e-32	142.9	Escherichia	cspH			ko:K03704,ko:K05808					ko00000,ko03000,ko03009				Bacteria	1NCMX@1224,1SDQS@1236,3XQ1Z@561,COG1278@1,COG1278@2	NA|NA|NA	K	Cold shock-like protein
C1_02232	316407.85674810	6.5e-13	80.1	Escherichia	gfcA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1NWQH@1224,1SNYV@1236,2F5RH@1,33YAD@2,3XR4W@561	NA|NA|NA		
C1_02233	316407.4062546	4.2e-118	430.6	Escherichia	ymcC	GO:0000271,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016051,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0045226,GO:0046379,GO:0071704,GO:1901576											Bacteria	1N1VT@1224,1RMP6@1236,28M8B@1,2ZAMG@2,3XNZQ@561	NA|NA|NA	M	extracellular polysaccharide metabolic process
C1_02234	481805.EcolC_2611	3.8e-139	500.7	Escherichia	ymcB												Bacteria	1NG4X@1224,1RZ19@1236,29T7B@1,30EE4@2,3XM59@561	NA|NA|NA	S	Capsule biosynthesis GfcC
C1_02235	155864.EDL933_1322	0.0	1432.2	Escherichia	wbfB			ko:K07277					ko00000,ko02000,ko03029	1.B.33			Bacteria	1MX3H@1224,1RQKV@1236,3XMA1@561,COG4775@1,COG4775@2	NA|NA|NA	M	extracellular polysaccharide metabolic process
C1_02236	155864.EDL933_1321	1.4e-214	751.9	Escherichia	comEA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K01991,ko:K02237	ko02026,map02026	M00429			ko00000,ko00001,ko00002,ko02000,ko02044	1.B.18,3.A.11.1,3.A.11.2			Bacteria	1N7GP@1224,1RQSM@1236,3XNQG@561,COG1596@1,COG1596@2	NA|NA|NA	M	polysaccharide export protein
C1_02237	155864.EDL933_1320	1.9e-77	295.0	Escherichia	etp	GO:0003674,GO:0003824,GO:0004721,GO:0004725,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0035335,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564	3.1.3.48	ko:K01104					ko00000,ko01000				Bacteria	1N0DZ@1224,1S92S@1236,3XPM0@561,COG0394@1,COG0394@2	NA|NA|NA	T	low molecular weight
C1_02238	316407.4062541	0.0	1355.5	Escherichia	wzc	GO:0000271,GO:0003674,GO:0003824,GO:0004672,GO:0004713,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0005975,GO:0005976,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009242,GO:0009987,GO:0016020,GO:0016021,GO:0016051,GO:0016301,GO:0016310,GO:0016462,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0018108,GO:0018193,GO:0018212,GO:0019538,GO:0031224,GO:0031226,GO:0033692,GO:0034637,GO:0034645,GO:0036211,GO:0038083,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046377,GO:0046777,GO:0071704,GO:0071944,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901576		ko:K16692					ko00000,ko01000,ko01001				Bacteria	1MVI9@1224,1RNB0@1236,3XN7H@561,COG0489@1,COG0489@2,COG3206@1,COG3206@2	NA|NA|NA	DM	Tyrosine-protein kinase
C1_02239	316407.1651481	1.6e-249	868.2	Escherichia	appA	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005975,GO:0006066,GO:0006793,GO:0006796,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008252,GO:0009056,GO:0009267,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016036,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0017144,GO:0019203,GO:0019637,GO:0019751,GO:0030288,GO:0030313,GO:0031667,GO:0031668,GO:0031669,GO:0031975,GO:0033517,GO:0033518,GO:0033554,GO:0034059,GO:0036293,GO:0036294,GO:0042221,GO:0042578,GO:0042594,GO:0042597,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044464,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0050308,GO:0050896,GO:0051716,GO:0052745,GO:0070482,GO:0070887,GO:0071453,GO:0071454,GO:0071496,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616	3.1.3.10,3.1.3.2,3.1.3.26	ko:K01085,ko:K01093	ko00010,ko00562,ko00740,ko01100,ko01120,map00010,map00562,map00740,map01100,map01120		R00548,R00947,R03372	RC00017,RC00078	ko00000,ko00001,ko01000			iEC042_1314.EC042_1065,iECABU_c1320.ECABU_c10140,iECSE_1348.ECSE_1042,iECW_1372.ECW_m1091,iEKO11_1354.EKO11_2850,iLF82_1304.LF82_0100,iNRG857_1313.NRG857_04465,iSF_1195.SF0982,iWFL_1372.ECW_m1091	Bacteria	1NR0Z@1224,1RYQE@1236,2DB79@1,2Z7K9@2,3XNWR@561	NA|NA|NA	S	myo-inositol hexakisphosphate dephosphorylation
C1_02241	316407.1651480	2.5e-214	751.1	Escherichia	cydB	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0016682,GO:0019646,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0070069,GO:0071944,GO:0097159,GO:1901363	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3		iECABU_c1320.ECABU_c10120,iLF82_1304.LF82_0101,iNRG857_1313.NRG857_04455,iYO844.BSU38750,ic_1306.c1120	Bacteria	1MURP@1224,1RYU0@1236,3XNHS@561,COG1294@1,COG1294@2	NA|NA|NA	C	oxidase, subunit
C1_02242	198214.SF0980	3.9e-295	1020.0	Gammaproteobacteria	cydA	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016679,GO:0016682,GO:0019646,GO:0022900,GO:0022904,GO:0032991,GO:0044237,GO:0044464,GO:0045333,GO:0055114,GO:0070069,GO:0071944	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3		iSBO_1134.SBO_2253,iSFxv_1172.SFxv_0621,iS_1188.S0577,iSbBS512_1146.SbBS512_E2337	Bacteria	1MV60@1224,1RN2U@1236,COG1271@1,COG1271@2	NA|NA|NA	C	oxidase, subunit
C1_02243	316407.1651478	1.1e-163	582.4	Escherichia	hyaF	GO:0000166,GO:0000302,GO:0001505,GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006091,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009987,GO:0010035,GO:0010181,GO:0010467,GO:0016043,GO:0016491,GO:0016661,GO:0017144,GO:0019538,GO:0022607,GO:0022900,GO:0032553,GO:0034641,GO:0036094,GO:0042133,GO:0042135,GO:0042221,GO:0042493,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044424,GO:0044464,GO:0046209,GO:0046210,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051604,GO:0055114,GO:0065003,GO:0065007,GO:0065008,GO:0070678,GO:0071704,GO:0071731,GO:0071840,GO:0072593,GO:0097159,GO:0097366,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901698,GO:1901700,GO:2001057		ko:K03618,ko:K12264	ko05132,map05132				ko00000,ko00001			iE2348C_1286.E2348C_2967,iECED1_1282.ECED1_3159	Bacteria	1MV2U@1224,1S2ZY@1236,3XNHN@561,COG1773@1,COG1773@2	NA|NA|NA	C	Hydrogenase-1 operon protein hyaF
C1_02244	198214.SF0977	2.4e-71	274.6	Gammaproteobacteria	senC	GO:0000041,GO:0003674,GO:0003824,GO:0004601,GO:0005048,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016020,GO:0016043,GO:0016209,GO:0016491,GO:0016684,GO:0019866,GO:0022607,GO:0030001,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0033218,GO:0034622,GO:0042221,GO:0042277,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0051775,GO:0051920,GO:0055114,GO:0065003,GO:0070887,GO:0071840,GO:0097237,GO:0098754,GO:0098869,GO:1990748		ko:K03619,ko:K07152					ko00000,ko03029				Bacteria	1RKWY@1224,1S7Q1@1236,COG1999@1,COG1999@2	NA|NA|NA	S	Hydrogenase-1 operon protein HyaE
C1_02245	316407.1651476	3e-107	394.4	Escherichia	hyaD	GO:0003674,GO:0003824,GO:0004175,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.23.51	ko:K03605,ko:K08315					ko00000,ko01000,ko01002				Bacteria	1RE1C@1224,1S1V0@1236,3XRHU@561,COG0680@1,COG0680@2	NA|NA|NA	O	Protease involved in the C-terminal processing of HyaB, the large subunit of hydrogenase 1
C1_02246	155864.EDL933_1312	2.2e-136	491.5	Escherichia	cybH	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0020037,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044569,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0071944,GO:0097159,GO:1901363,GO:1902494		ko:K03620	ko02020,map02020				ko00000,ko00001				Bacteria	1MU87@1224,1RNTH@1236,3XN5T@561,COG1969@1,COG1969@2	NA|NA|NA	C	Ni Fe-hydrogenase 1 B-type cytochrome subunit
C1_02247	198214.SF0974	0.0	1248.0	Gammaproteobacteria	hyaB	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016151,GO:0016491,GO:0022900,GO:0030288,GO:0030313,GO:0031975,GO:0032991,GO:0042597,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0044569,GO:0045333,GO:0046872,GO:0046914,GO:0055114,GO:0071944,GO:1902494	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120		R08034	RC00250	ko00000,ko00001,ko01000			iSbBS512_1146.SbBS512_E2342,ic_1306.c3731	Bacteria	1MWFJ@1224,1RMC3@1236,COG0374@1,COG0374@2	NA|NA|NA	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family
C1_02248	199310.c1113	5e-220	770.0	Escherichia	hyaA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009897,GO:0009986,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0032991,GO:0042597,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044569,GO:0045333,GO:0048037,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071944,GO:0098552,GO:0098567,GO:1902494	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120		R08034	RC00250	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_76,iUTI89_1310.UTI89_C1040	Bacteria	1MWAC@1224,1RNTJ@1236,3XM4G@561,COG1740@1,COG1740@2	NA|NA|NA	C	This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD1 is believed to have a role in hydrogen cycling during fermentative growth
C1_02250	199310.c1110	3.1e-108	397.9	Escherichia	yccA	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016021,GO:0019222,GO:0030162,GO:0031224,GO:0044425,GO:0044464,GO:0050789,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071944,GO:0080090		ko:K06890,ko:K19416		M00742			ko00000,ko00002,ko02000	1.A.14.2.1			Bacteria	1MU69@1224,1RRVZ@1236,3XNC8@561,COG0670@1,COG0670@2	NA|NA|NA	S	Belongs to the BI1 family
C1_02251	155864.EDL933_1237	2e-55	221.5	Escherichia	tusE	GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097163,GO:0140104,GO:1901360		ko:K11179	ko04122,map04122				ko00000,ko00001,ko01000,ko03016				Bacteria	1RGVG@1224,1S5ZA@1236,3XPQI@561,COG2920@1,COG2920@2	NA|NA|NA	J	Part of a sulfur-relay system
C1_02252	155864.EDL933_1236	2e-45	188.0	Escherichia	acyP	GO:0003674,GO:0003824,GO:0003998,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016787,GO:0016817,GO:0016818,GO:0050896	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120		R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000			iSB619.SA_RS07020,iSBO_1134.SBO_2263,iSF_1195.SF0969,iSFxv_1172.SFxv_1053,iS_1188.S1036	Bacteria	1N6NU@1224,1SCPF@1236,3XPZE@561,COG1254@1,COG1254@2	NA|NA|NA	C	acylphosphatase activity
C1_02253	155864.EDL933_1235	5.1e-223	780.0	Escherichia	rlmI	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.191	ko:K06969					ko00000,ko01000,ko03009				Bacteria	1MUGB@1224,1RN7Z@1236,3XPG1@561,COG1092@1,COG1092@2	NA|NA|NA	J	Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA
C1_02254	1440052.EAKF1_ch0500	3.3e-52	210.7	Escherichia	hspQ			ko:K11940					ko00000,ko03036				Bacteria	1RGWN@1224,1S62D@1236,3XPQ5@561,COG3785@1,COG3785@2	NA|NA|NA	S	Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress
C1_02255	155864.EDL933_1233	1.9e-71	275.0	Escherichia	yccU	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.5.1.49	ko:K01740,ko:K06929	ko00270,ko01100,map00270,map01100		R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000				Bacteria	1N03D@1224,1S3T2@1236,3XPIE@561,COG1832@1,COG1832@2	NA|NA|NA	S	cofactor binding
C1_02256	155864.EDL933_1231	1.5e-115	422.2	Escherichia	yccT			ko:K09909					ko00000				Bacteria	1RK33@1224,1RZRX@1236,3XNYU@561,COG3110@1,COG3110@2	NA|NA|NA	S	Uncharacterized protein conserved in bacteria (DUF2057)
C1_02257	155864.EDL933_1230	1.5e-82	312.0	Escherichia	mgsA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0008150,GO:0008152,GO:0008929,GO:0009058,GO:0009438,GO:0009987,GO:0016829,GO:0016835,GO:0016838,GO:0019242,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0071704,GO:1901576	4.2.3.3	ko:K01734	ko00640,ko01120,map00640,map01120		R01016	RC00424	ko00000,ko00001,ko01000			iECUMN_1333.ECUMN_1153,iYL1228.KPN_00992	Bacteria	1RD3D@1224,1S3XN@1236,3XN43@561,COG1803@1,COG1803@2	NA|NA|NA	G	methylglyoxal synthase activity
C1_02258	316407.1651471	0.0	1367.8	Escherichia	helD	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1902494	3.6.4.12	ko:K03658					ko00000,ko01000,ko03400				Bacteria	1MVWI@1224,1RN1N@1236,3XP55@561,COG0210@1,COG0210@2	NA|NA|NA	L	Helicase IV catalyzes the unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand in a reaction that is dependent upon the hydrolysis of ATP
C1_02259	198214.SF0963	1.4e-75	288.9	Gammaproteobacteria	yccF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1RA96@1224,1S1ZC@1236,COG3304@1,COG3304@2	NA|NA|NA	S	Membrane
C1_02260	155864.EDL933_1227	0.0	1416.7	Escherichia	yccS	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1MWR1@1224,1RNIJ@1236,3XMFN@561,COG1289@1,COG1289@2	NA|NA|NA	S	FUSC-like inner membrane protein yccS
C1_02261	316407.4062523	2.3e-113	414.8	Escherichia	sxy	GO:0006355,GO:0006810,GO:0007154,GO:0008150,GO:0009290,GO:0009292,GO:0009294,GO:0009605,GO:0009889,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0015931,GO:0019219,GO:0019222,GO:0030420,GO:0031323,GO:0031326,GO:0031344,GO:0031346,GO:0031668,GO:0044087,GO:0044089,GO:0044093,GO:0044764,GO:0048518,GO:0048522,GO:0050657,GO:0050789,GO:0050794,GO:0050896,GO:0051027,GO:0051090,GO:0051091,GO:0051128,GO:0051130,GO:0051171,GO:0051179,GO:0051234,GO:0051252,GO:0051704,GO:0051716,GO:0060255,GO:0060491,GO:0065007,GO:0065009,GO:0071496,GO:0071702,GO:0071705,GO:0080090,GO:0098657,GO:1903506,GO:1903656,GO:1903658,GO:2000112,GO:2001141		ko:K07343					ko00000				Bacteria	1RDWD@1224,1S496@1236,3XN76@561,COG3070@1,COG3070@2	NA|NA|NA	K	Induces low levels of natural DNA uptake by inducing transcription of the competence genes (the CRP-S regulon) required for DNA transformation. Induction of the CRP-S regulon also requires Sxy-activated promoter (CRP-S), cAMP receptor protein (CRP) and cAMP. Induces CRP-S site-containing genes which are involved in genome maintenance and transcription or encoding transposases and toxin-antitoxin pairs
C1_02262	155864.EDL933_1225	5.7e-86	323.6	Escherichia	sulA	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0010564,GO:0010948,GO:0031333,GO:0031668,GO:0032271,GO:0032272,GO:0032465,GO:0032466,GO:0033554,GO:0034260,GO:0043086,GO:0043087,GO:0043254,GO:0044087,GO:0044092,GO:0045786,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051128,GO:0051129,GO:0051302,GO:0051336,GO:0051346,GO:0051716,GO:0051726,GO:0051782,GO:0065007,GO:0065009,GO:0071496,GO:1903664,GO:1903665,GO:2000241,GO:2000242,GO:2000244,GO:2000245		ko:K13053,ko:K14160					ko00000,ko03036,ko03400				Bacteria	1RD22@1224,1RYWE@1236,3XMSR@561,COG5404@1,COG5404@2	NA|NA|NA	D	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
C1_02263	198214.SF0957	4.3e-197	693.7	Gammaproteobacteria	ompA	GO:0000746,GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006950,GO:0006974,GO:0008150,GO:0009279,GO:0009597,GO:0009605,GO:0009607,GO:0009615,GO:0009987,GO:0015267,GO:0015288,GO:0016020,GO:0016021,GO:0016032,GO:0019058,GO:0019867,GO:0022803,GO:0022829,GO:0022857,GO:0030260,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0032991,GO:0033554,GO:0034220,GO:0042802,GO:0043207,GO:0044403,GO:0044409,GO:0044419,GO:0044425,GO:0044462,GO:0044464,GO:0044764,GO:0046718,GO:0046930,GO:0050896,GO:0051179,GO:0051234,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051806,GO:0051828,GO:0055085,GO:0071944,GO:0098796		ko:K03286,ko:K03640					ko00000,ko02000	1.B.6,2.C.1.2		iECIAI1_1343.ECIAI1_0998,iECNA114_1301.ECNA114_1035,iECSF_1327.ECSF_0871,iUTI89_1310.UTI89_C1022	Bacteria	1N6EM@1224,1RMJ7@1236,COG2885@1,COG2885@2,COG3637@1,COG3637@2	NA|NA|NA	M	Belongs to the ompA family
C1_02264	155864.EDL933_1223	4.3e-77	293.9	Escherichia	matP	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0006996,GO:0007059,GO:0008150,GO:0009987,GO:0016043,GO:0032991,GO:0032993,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043565,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0051276,GO:0051301,GO:0071840,GO:0097047,GO:0097159,GO:1901363		ko:K09911					ko00000				Bacteria	1RA57@1224,1S28S@1236,3XMGH@561,COG3120@1,COG3120@2	NA|NA|NA	D	Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain
C1_02265	155864.EDL933_1222	0.0	1170.2	Escherichia	ycbZ			ko:K04770					ko00000,ko01000,ko01002				Bacteria	1MWGB@1224,1RMPC@1236,3XNXW@561,COG1067@1,COG1067@2	NA|NA|NA	O	Belongs to the peptidase S16 family
C1_02266	199310.c1090	1.1e-115	422.5	Escherichia	fabA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0008693,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016860,GO:0016863,GO:0019171,GO:0019752,GO:0032787,GO:0034017,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0047451,GO:0071704,GO:0072330,GO:1901576	4.2.1.59,5.3.3.14	ko:K01716	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00083	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07639	RC00831,RC01078,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004			iAF1260.b0954,iB21_1397.B21_00965,iBWG_1329.BWG_0806,iE2348C_1286.E2348C_0940,iEC042_1314.EC042_1039,iECBD_1354.ECBD_2641,iECB_1328.ECB_00958,iECDH10B_1368.ECDH10B_1024,iECD_1391.ECD_00958,iECED1_1282.ECED1_0977,iECH74115_1262.ECH74115_1118,iECIAI1_1343.ECIAI1_0995,iECIAI39_1322.ECIAI39_2193,iECNA114_1301.ECNA114_1032,iECO103_1326.ECO103_1000,iECO111_1330.ECO111_1022,iECO26_1355.ECO26_1081,iECOK1_1307.ECOK1_1013,iECS88_1305.ECS88_0975,iECSF_1327.ECSF_0868,iECSP_1301.ECSP_1060,iECUMN_1333.ECUMN_1143,iECW_1372.ECW_m1064,iECs_1301.ECs1038,iEKO11_1354.EKO11_2876,iETEC_1333.ETEC_1024,iEcE24377_1341.EcE24377A_1068,iEcHS_1320.EcHS_A1063,iEcSMS35_1347.EcSMS35_2166,iEcolC_1368.EcolC_2642,iG2583_1286.G2583_1189,iJO1366.b0954,iJR904.b0954,iLF82_1304.LF82_0604,iSBO_1134.SBO_2277,iSDY_1059.SDY_0927,iSF_1195.SF0954,iSSON_1240.SSON_0958,iSbBS512_1146.SbBS512_E2362,iUMNK88_1353.UMNK88_1108,iWFL_1372.ECW_m1064,iY75_1357.Y75_RS04955,iZ_1308.Z1304,ic_1306.c1090	Bacteria	1MWV8@1224,1RP6W@1236,3XMG8@561,COG0764@1,COG0764@2	NA|NA|NA	I	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length
C1_02267	1440052.EAKF1_ch0513c	1.7e-23	114.4	Gammaproteobacteria	rmf	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006950,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032055,GO:0032268,GO:0032269,GO:0033554,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043555,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112,GO:2000113		ko:K03812					ko00000,ko03009				Bacteria	1N761@1224,1SCIC@1236,COG3130@1,COG3130@2	NA|NA|NA	J	During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes)
C1_02268	198214.SF0953	7.4e-103	379.8	Gammaproteobacteria	ymbA	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030288,GO:0030312,GO:0030313,GO:0031224,GO:0031225,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0036405,GO:0036406,GO:0042597,GO:0042802,GO:0044425,GO:0044462,GO:0044464,GO:0071944,GO:0098552		ko:K09857					ko00000				Bacteria	1PJIN@1224,1RQTB@1236,COG3009@1,COG3009@2	NA|NA|NA	S	protein conserved in bacteria
C1_02269	316407.1651463	7.7e-310	1068.9	Escherichia	pqiB	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0009987,GO:0010876,GO:0016043,GO:0030288,GO:0030313,GO:0031975,GO:0033036,GO:0042597,GO:0042802,GO:0044464,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071840,GO:0120009		ko:K02067,ko:K06192	ko02010,map02010	M00210,M00669,M00670			ko00000,ko00001,ko00002,ko02000	3.A.1.27			Bacteria	1MU1T@1224,1RN89@1236,3XN55@561,COG1463@1,COG1463@2,COG3008@1,COG3008@2	NA|NA|NA	Q	Paraquat-inducible protein B
C1_02270	198214.SF0951	5.3e-234	816.6	Gammaproteobacteria	pqiA	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K03808					ko00000				Bacteria	1MWG1@1224,1RM9Z@1236,COG2995@1,COG2995@2	NA|NA|NA	S	paraquat-inducible protein A
C1_02271	316407.4062519	0.0	1226.5	Escherichia	uup	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010528,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031323,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0070894,GO:0071944,GO:0080090,GO:0097159,GO:1901363		ko:K15738					ko00000,ko02000	3.A.1.120.6			Bacteria	1MU37@1224,1RPCU@1236,3XPE2@561,COG0488@1,COG0488@2	NA|NA|NA	S	ABC transporter, ATP-binding protein
C1_02272	316407.4062515	0.0	1413.7	Escherichia	rlmL	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016423,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.173,2.1.1.191,2.1.1.264,2.1.1.72	ko:K00571,ko:K06969,ko:K07444,ko:K12297			R07234	RC00003	ko00000,ko01000,ko02048,ko03009				Bacteria	1MUQM@1224,1RNMH@1236,3XNPW@561,COG0116@1,COG0116@2,COG1092@1,COG1092@2	NA|NA|NA	J	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C1_02273	198214.SF0948	7e-214	749.6	Gammaproteobacteria	ycbX	GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009636,GO:0009987,GO:0019748,GO:0042221,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044248,GO:0044424,GO:0044464,GO:0046858,GO:0050896,GO:0098754	1.17.1.1	ko:K00523,ko:K04755,ko:K07140,ko:K08952,ko:K08953,ko:K08954	ko00520,map00520		R03391,R03392	RC00230	ko00000,ko00001,ko00194,ko01000				Bacteria	1MXN2@1224,1RMN7@1236,COG0633@1,COG0633@2,COG3217@1,COG3217@2	NA|NA|NA	C	Mosc domain protein beta barrel domain protein
C1_02274	316407.85674796	3.9e-101	374.0	Escherichia	zapC	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008150,GO:0032153,GO:0042802,GO:0044464,GO:0050789,GO:0050794,GO:0051302,GO:0065007		ko:K18657					ko00000,ko03036				Bacteria	1N1DT@1224,1RYK3@1236,28I7M@1,2Z8AH@2,3XM3S@561	NA|NA|NA	D	Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ
C1_02275	155864.EDL933_1211	8.4e-190	669.5	Escherichia	pyrD	GO:0000166,GO:0003674,GO:0003824,GO:0004152,GO:0004158,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0010181,GO:0016020,GO:0016491,GO:0016627,GO:0016634,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0032553,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.3.1.14,1.3.5.2	ko:K00254,ko:K02823,ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01868,R01869	RC00051	ko00000,ko00001,ko00002,ko01000			iEC042_1314.EC042_1029,iECIAI39_1322.ECIAI39_2202,iECUMN_1333.ECUMN_1134,iEcSMS35_1347.EcSMS35_2174,iPC815.YPO1415,iYL1228.KPN_00974	Bacteria	1MU7C@1224,1RMCP@1236,3XNCA@561,COG0167@1,COG0167@2	NA|NA|NA	F	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor
C1_02276	316407.85674795	3.5e-123	447.6	Gammaproteobacteria	ycbF	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006457,GO:0006950,GO:0006974,GO:0007155,GO:0008150,GO:0009987,GO:0016043,GO:0022610,GO:0030030,GO:0030288,GO:0030313,GO:0031975,GO:0033554,GO:0042597,GO:0043711,GO:0044183,GO:0044464,GO:0050896,GO:0051716,GO:0061077,GO:0071840		ko:K07346,ko:K07353,ko:K15540					ko00000,ko02035,ko02044,ko03110				Bacteria	1RAQF@1224,1S585@1236,COG3121@1,COG3121@2	NA|NA|NA	NU	chaperone
C1_02277	198214.SF0944	2.6e-100	371.3	Gammaproteobacteria	bcfF	GO:0007155,GO:0008150,GO:0009987,GO:0022610,GO:0031589,GO:0042710,GO:0043708,GO:0043709,GO:0044010,GO:0044764,GO:0051704,GO:0090605,GO:0090609											Bacteria	1N3AG@1224,1SBD7@1236,COG3539@1,COG3539@2	NA|NA|NA	NU	Fimbrial
C1_02278	316407.4062510	8.4e-96	356.3	Gammaproteobacteria	bcfE	GO:0007155,GO:0008150,GO:0009987,GO:0022610,GO:0031589,GO:0042710,GO:0043708,GO:0043709,GO:0044010,GO:0044764,GO:0051704,GO:0090605,GO:0090609											Bacteria	1RBMU@1224,1S31S@1236,COG3539@1,COG3539@2	NA|NA|NA	NU	Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces
C1_02279	316407.4062509	1.7e-204	718.4	Gammaproteobacteria	elfG	GO:0007155,GO:0008150,GO:0009314,GO:0009628,GO:0009987,GO:0022610,GO:0031589,GO:0042710,GO:0043708,GO:0043709,GO:0044010,GO:0044764,GO:0050896,GO:0051704,GO:0090605,GO:0090609											Bacteria	1R6MJ@1224,1S13V@1236,COG3539@1,COG3539@2	NA|NA|NA	NU	Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces
C1_02280	198214.SF0941	0.0	1717.6	Gammaproteobacteria	ycbS	GO:0003674,GO:0005215,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0008201,GO:0009279,GO:0009297,GO:0009987,GO:0015267,GO:0015288,GO:0015473,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0022803,GO:0022829,GO:0022857,GO:0030030,GO:0030031,GO:0030312,GO:0030313,GO:0031975,GO:0043167,GO:0043168,GO:0043711,GO:0044085,GO:0044462,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071840,GO:0071944,GO:0097367,GO:1901681		ko:K07347,ko:K07354	ko05133,map05133				ko00000,ko00001,ko02000,ko02035,ko02044	1.B.11.3			Bacteria	1MUHE@1224,1RMPU@1236,COG3188@1,COG3188@2	NA|NA|NA	NU	Usher protein
C1_02281	316407.4062507	3.1e-127	461.1	Gammaproteobacteria	elfD	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006457,GO:0006950,GO:0006974,GO:0007155,GO:0008150,GO:0009987,GO:0016043,GO:0022610,GO:0030030,GO:0030288,GO:0030313,GO:0031975,GO:0033554,GO:0042597,GO:0043711,GO:0044183,GO:0044464,GO:0050896,GO:0051716,GO:0061077,GO:0071840		ko:K07346,ko:K07353,ko:K15540					ko00000,ko02035,ko02044,ko03110				Bacteria	1NSWH@1224,1SN1W@1236,COG3121@1,COG3121@2	NA|NA|NA	NU	Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae
C1_02282	155864.EDL933_1202	5e-72	277.3	Gammaproteobacteria	elfA	GO:0005575,GO:0005623,GO:0007155,GO:0008150,GO:0009289,GO:0009987,GO:0022610,GO:0031589,GO:0042710,GO:0042995,GO:0043708,GO:0043709,GO:0044010,GO:0044464,GO:0044764,GO:0051704,GO:0090605,GO:0090609		ko:K07345,ko:K07351	ko05133,map05133				ko00000,ko00001,ko02035,ko02044				Bacteria	1RFEW@1224,1S5AF@1236,COG3539@1,COG3539@2	NA|NA|NA	NU	Fimbrial
C1_02283	316407.4062505	1.3e-102	379.0	Escherichia	ssuE	GO:0003674,GO:0003824,GO:0006082,GO:0006790,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008752,GO:0009056,GO:0009267,GO:0009605,GO:0009970,GO:0009987,GO:0009991,GO:0016043,GO:0016054,GO:0016491,GO:0016645,GO:0016646,GO:0019694,GO:0022607,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042594,GO:0043933,GO:0044085,GO:0044237,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0046306,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051716,GO:0055114,GO:0065003,GO:0071496,GO:0071704,GO:0071840,GO:1901575	1.5.1.38	ko:K00299	ko00740,ko00920,ko01100,map00740,map00920,map01100		R05706,R07210,R10206	RC00126,RC01779,RC02556	ko00000,ko00001,ko01000			iAF1260.b0937,iB21_1397.B21_00948,iBWG_1329.BWG_0789,iE2348C_1286.E2348C_0930,iECBD_1354.ECBD_2658,iECB_1328.ECB_00941,iECDH10B_1368.ECDH10B_1007,iECDH1ME8569_1439.ECDH1ME8569_0888,iECD_1391.ECD_00941,iECIAI1_1343.ECIAI1_0978,iECO103_1326.ECO103_0982,iECW_1372.ECW_m1047,iEKO11_1354.EKO11_2893,iETEC_1333.ETEC_1005,iEcDH1_1363.EcDH1_2706,iEcE24377_1341.EcE24377A_1052,iEcHS_1320.EcHS_A1046,iEcolC_1368.EcolC_2659,iJO1366.b0937,iSbBS512_1146.SbBS512_E2381,iUMNK88_1353.UMNK88_1092,iWFL_1372.ECW_m1047,iY75_1357.Y75_RS04870	Bacteria	1MX40@1224,1RQGZ@1236,3XMDI@561,COG0431@1,COG0431@2	NA|NA|NA	S	Catalyzes an NADPH-dependent reduction of FMN, but is also able to reduce FAD or riboflavin
C1_02284	469008.B21_00947	1.6e-174	618.6	Escherichia	ssuA	GO:0003674,GO:0005215,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0044237		ko:K02051,ko:K15553	ko00920,ko02010,map00920,map02010	M00188,M00436			ko00000,ko00001,ko00002,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.2		iAF1260.b0936,iBWG_1329.BWG_0788,iECDH10B_1368.ECDH10B_1006,iECDH1ME8569_1439.ECDH1ME8569_0887,iECSF_1327.ECSF_0857,iETEC_1333.ETEC_1004,iEcDH1_1363.EcDH1_2707,iJO1366.b0936,iSSON_1240.SSON_0939,iY75_1357.Y75_RS04865	Bacteria	1MV9S@1224,1RQJK@1236,3XQ8C@561,COG0715@1,COG0715@2	NA|NA|NA	P	aliphatic sulfonates
C1_02285	362663.ECP_0947	1.6e-216	758.4	Escherichia	ssuD	GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0005515,GO:0006082,GO:0006790,GO:0006950,GO:0008150,GO:0008152,GO:0008726,GO:0009056,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016054,GO:0016491,GO:0016705,GO:0016712,GO:0019694,GO:0042802,GO:0044237,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0046306,GO:0050896,GO:0055114,GO:0071704,GO:1901575	1.14.14.5	ko:K04091	ko00920,map00920		R07210,R10206	RC01779,RC02556	ko00000,ko00001,ko01000			iECIAI39_1322.ECIAI39_2212,iPC815.YPO3625	Bacteria	1MWMV@1224,1RP4Z@1236,3XQSB@561,COG2141@1,COG2141@2	NA|NA|NA	C	Belongs to the SsuD family
C1_02286	316407.85674791	1.3e-137	495.7	Escherichia	ssuC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0071944	1.14.14.5	ko:K04091,ko:K15554	ko00920,ko02010,map00920,map02010	M00436	R07210,R10206	RC01779,RC02556	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.17.2		iAF1260.b0934,iB21_1397.B21_00945,iBWG_1329.BWG_0786,iEC55989_1330.EC55989_0983,iECBD_1354.ECBD_2661,iECB_1328.ECB_00938,iECDH10B_1368.ECDH10B_1004,iECDH1ME8569_1439.ECDH1ME8569_0885,iECD_1391.ECD_00938,iECIAI1_1343.ECIAI1_0975,iECNA114_1301.ECNA114_1020,iECO103_1326.ECO103_0979,iECO26_1355.ECO26_1061,iECSF_1327.ECSF_0855,iECW_1372.ECW_m1044,iEKO11_1354.EKO11_2896,iETEC_1333.ETEC_1002,iEcDH1_1363.EcDH1_2709,iEcE24377_1341.EcE24377A_1036,iEcHS_1320.EcHS_A1043,iEcolC_1368.EcolC_2662,iJO1366.b0934,iSSON_1240.SSON_0937,iUMNK88_1353.UMNK88_1089,iWFL_1372.ECW_m1044,iY75_1357.Y75_RS04855	Bacteria	1MWS0@1224,1RR15@1236,3XPXV@561,COG0600@1,COG0600@2	NA|NA|NA	P	aliphatic sulfonates transport permease protein ssuC
C1_02287	198214.SF0930	5.5e-133	480.3	Gammaproteobacteria	ssuB	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K02049,ko:K15555	ko00920,ko02010,map00920,map02010	M00188,M00436			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.2			Bacteria	1MUKI@1224,1RP0J@1236,COG1116@1,COG1116@2	NA|NA|NA	P	Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import. Responsible for energy coupling to the transport system
C1_02288	155864.EDL933_1196	0.0	1740.3	Escherichia	pepN	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0009056,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0033218,GO:0034641,GO:0042277,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100		R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002			iECIAI1_1343.ECIAI1_0973,iECO103_1326.ECO103_0977,iECP_1309.ECP_0944,iECSE_1348.ECSE_0993,iECW_1372.ECW_m1042,iEKO11_1354.EKO11_2898,iWFL_1372.ECW_m1042	Bacteria	1MUCI@1224,1RMA7@1236,3XM5I@561,COG0308@1,COG0308@2	NA|NA|NA	E	Aminopeptidase N is involved in the degradation of intracellular peptides generated by protein breakdown during normal growth as well as in response to nutrient starvation
C1_02289	198214.SF0928	1.9e-233	814.7	Gammaproteobacteria	pncB	GO:0000183,GO:0001302,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006139,GO:0006325,GO:0006342,GO:0006348,GO:0006355,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0007568,GO:0007569,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009266,GO:0009408,GO:0009435,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016043,GO:0016458,GO:0016874,GO:0016879,GO:0018130,GO:0019219,GO:0019222,GO:0019357,GO:0019358,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032502,GO:0034641,GO:0034654,GO:0040029,GO:0043094,GO:0043173,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045814,GO:0045892,GO:0045934,GO:0046483,GO:0046496,GO:0046497,GO:0048519,GO:0048523,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051186,GO:0051188,GO:0051252,GO:0051253,GO:0051276,GO:0055086,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100		R01724	RC00033	ko00000,ko00001,ko01000			iAF1260.b0931,iBWG_1329.BWG_0783,iECDH10B_1368.ECDH10B_1001,iECDH1ME8569_1439.ECDH1ME8569_0882,iECIAI39_1322.ECIAI39_2216,iETEC_1333.ETEC_0999,iEcDH1_1363.EcDH1_2712,iEcSMS35_1347.EcSMS35_2189,iJO1366.b0931,iJR904.b0931,iUMNK88_1353.UMNK88_1085,iY75_1357.Y75_RS04840	Bacteria	1MV8U@1224,1RQWS@1236,COG1488@1,COG1488@2	NA|NA|NA	F	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C1_02290	198214.SF0927	1.2e-271	941.8	Gammaproteobacteria	asnS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004816,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006421,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iSDY_1059.SDY_2327	Bacteria	1MWFV@1224,1RMU4@1236,COG0017@1,COG0017@2	NA|NA|NA	J	Asparaginyl-tRNA synthetase
C1_02291	316407.1651450	9.6e-208	729.2	Escherichia	ompF	GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006855,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009279,GO:0009987,GO:0015031,GO:0015075,GO:0015238,GO:0015267,GO:0015288,GO:0015318,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0015893,GO:0016020,GO:0016021,GO:0016043,GO:0019867,GO:0019904,GO:0022607,GO:0022803,GO:0022804,GO:0022829,GO:0022838,GO:0022857,GO:0022884,GO:0022885,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0032991,GO:0033036,GO:0034220,GO:0034702,GO:0042221,GO:0042493,GO:0042802,GO:0042886,GO:0042887,GO:0042891,GO:0042895,GO:0042912,GO:0043213,GO:0043933,GO:0044085,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0046930,GO:0047485,GO:0050896,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0070206,GO:0070207,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0097718,GO:0098796,GO:1902495,GO:1904680,GO:1990351		ko:K09476	ko01501,ko02020,map01501,map02020	M00746			ko00000,ko00001,ko00002,ko01504,ko02000	1.B.1.1.1		iECH74115_1262.ECH74115_1090,iECSP_1301.ECSP_1034,iECs_1301.ECs1012,iG2583_1286.G2583_1164,iZ_1308.Z1276	Bacteria	1MVRY@1224,1RNBS@1236,3XPDU@561,COG3203@1,COG3203@2	NA|NA|NA	M	Belongs to the Gram-negative porin family
C1_02292	316407.1651449	1.1e-225	788.9	Escherichia	aspC	GO:0003674,GO:0003824,GO:0004069,GO:0004838,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006531,GO:0006532,GO:0006551,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0008793,GO:0009058,GO:0009066,GO:0009067,GO:0009072,GO:0009073,GO:0009081,GO:0009082,GO:0009094,GO:0009095,GO:0009098,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0019292,GO:0019438,GO:0019752,GO:0019842,GO:0030170,GO:0033585,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050048,GO:0050662,GO:0070279,GO:0070547,GO:0071704,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223	2.6.1.1,2.6.1.57	ko:K00813,ko:K00832	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	M00024,M00025,M00034,M00040	R00355,R00694,R00734,R00896,R01731,R02433,R02619,R05052,R07396,R10845	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007			iECSE_1348.ECSE_4347,iPC815.YPO1410,iSFxv_1172.SFxv_1000	Bacteria	1MUT0@1224,1RN02@1236,3XNR8@561,COG1448@1,COG1448@2	NA|NA|NA	E	L-aspartate:2-oxoglutarate aminotransferase activity
C1_02293	198214.SF0924	3.2e-126	457.6	Gammaproteobacteria	ycbL	GO:0003674,GO:0003824,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006089,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019243,GO:0019752,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0051596,GO:0061727,GO:0071704,GO:1901575,GO:1901615	3.1.2.6	ko:K01069	ko00620,map00620		R01736	RC00004,RC00137	ko00000,ko00001,ko01000				Bacteria	1MUDN@1224,1RMMG@1236,COG0491@1,COG0491@2	NA|NA|NA	P	COG0491 Zn-dependent hydrolases, including glyoxylases
C1_02294	155864.EDL933_1189	5.7e-100	370.2	Escherichia	ycbK			ko:K02395					ko00000,ko02035				Bacteria	1MWW2@1224,1RS5K@1236,3XNAB@561,COG3108@1,COG3108@2	NA|NA|NA	S	Bacterial protein of unknown function (DUF882)
C1_02295	469008.B21_00936	0.0	1226.8	Escherichia	ycbB	GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0006508,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008233,GO:0008234,GO:0008236,GO:0008238,GO:0009273,GO:0009987,GO:0016740,GO:0016746,GO:0016755,GO:0016787,GO:0016807,GO:0017171,GO:0019538,GO:0033554,GO:0042546,GO:0043164,GO:0043170,GO:0044036,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0050896,GO:0051716,GO:0070004,GO:0070008,GO:0070011,GO:0071554,GO:0071704,GO:0071840,GO:0071972,GO:0140096,GO:1901564		ko:K21470					ko00000,ko01002,ko01011				Bacteria	1MV14@1224,1RQR7@1236,3XP8Y@561,COG2989@1,COG2989@2	NA|NA|NA	M	cysteine-type carboxypeptidase activity
C1_02296	155864.EDL933_1187	0.0	2781.9	Escherichia	mukB	GO:0000166,GO:0000793,GO:0000796,GO:0000819,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0005737,GO:0005829,GO:0006323,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008144,GO:0008150,GO:0009987,GO:0016043,GO:0017076,GO:0019001,GO:0022402,GO:0030261,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032991,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044422,GO:0044424,GO:0044427,GO:0044444,GO:0044446,GO:0044464,GO:0044815,GO:0051276,GO:0051301,GO:0071103,GO:0071840,GO:0097159,GO:0097367,GO:0098813,GO:1901265,GO:1901363	3.5.4.40	ko:K03632,ko:K18286	ko00130,ko01110,map00130,map01110		R10695	RC00477	ko00000,ko00001,ko01000,ko03036				Bacteria	1MUWM@1224,1RPFF@1236,3XMJT@561,COG3096@1,COG3096@2	NA|NA|NA	D	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C1_02297	481805.EcolC_2673	5.9e-126	456.8	Escherichia	mukE	GO:0005575,GO:0007059,GO:0008150,GO:0009295,GO:0009987		ko:K03804,ko:K21006	ko02025,map02025				ko00000,ko00001,ko03036				Bacteria	1MXYN@1224,1RRBE@1236,3XP1Z@561,COG3095@1,COG3095@2	NA|NA|NA	D	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
C1_02298	198214.SF0918	1.8e-248	864.8	Gammaproteobacteria	mukF	GO:0005575,GO:0009295		ko:K03633					ko00000,ko03036				Bacteria	1N0D6@1224,1RN7P@1236,COG3006@1,COG3006@2	NA|NA|NA	D	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
C1_02299	316407.1651445	8.6e-150	536.2	Escherichia	cmoM	GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0097697,GO:0140098,GO:0140101,GO:1901360		ko:K06219,ko:K20444					ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4		Bacteria	1MY0S@1224,1RP69@1236,3XPFZ@561,COG2227@1,COG2227@2	NA|NA|NA	J	Catalyzes the methylation of 5-carboxymethoxyuridine (cmo5U) to form 5-methoxycarbonylmethoxyuridine (mcmo5U) at position 34 in tRNAs
C1_02300	198214.SF0916	1.1e-144	519.2	Gammaproteobacteria	ycbC	GO:0000270,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006807,GO:0008150,GO:0008152,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0030203,GO:0031224,GO:0042546,GO:0043164,GO:0043170,GO:0044085,GO:0044425,GO:0044464,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901564											Bacteria	1MVW8@1224,1RNZC@1236,COG1434@1,COG1434@2	NA|NA|NA	S	Gram-negative-bacterium-type cell wall biogenesis
C1_02301	155864.EDL933_1182	8.8e-175	619.4	Escherichia	ycbJ												Bacteria	1P7ZI@1224,1RRJJ@1236,3XM71@561,COG3173@1,COG3173@2	NA|NA|NA	S	Phosphotransferase enzyme family
C1_02302	198214.SF0914	2.7e-137	494.6	Gammaproteobacteria	kdsB	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005996,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008690,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019294,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046394,GO:0046400,GO:0046401,GO:0046872,GO:0070567,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005			iAF1260.b0918,iB21_1397.B21_00929,iBWG_1329.BWG_0770,iECBD_1354.ECBD_2677,iECB_1328.ECB_00922,iECDH10B_1368.ECDH10B_0988,iECDH1ME8569_1439.ECDH1ME8569_0869,iECD_1391.ECD_00922,iETEC_1333.ETEC_0986,iEcDH1_1363.EcDH1_2725,iEcHS_1320.EcHS_A1025,iEcolC_1368.EcolC_2678,iJO1366.b0918,iJR904.b0918,iPC815.YPO1400,iUMNK88_1353.UMNK88_1071,iY75_1357.Y75_RS04770	Bacteria	1MUUU@1224,1RMAE@1236,COG1212@1,COG1212@2	NA|NA|NA	M	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C1_02303	1440052.EAKF1_ch0540c	9.5e-28	128.6	Escherichia	ycaR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.7.1.130	ko:K00912,ko:K09791	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005				Bacteria	1N6Y2@1224,1SCFF@1236,3XPZS@561,COG2835@1,COG2835@2	NA|NA|NA	S	Belongs to the UPF0434 family
C1_02304	198214.SF0912	2.7e-243	847.4	Gammaproteobacteria	ycaQ			ko:K09927					ko00000				Bacteria	1N40B@1224,1RPYB@1236,COG3214@1,COG3214@2	NA|NA|NA	S	protein conserved in bacteria
C1_02305	198214.SF0911	2.9e-187	661.0	Gammaproteobacteria	lpxK	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008654,GO:0009029,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019637,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046401,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005			iBWG_1329.BWG_0767,iECDH10B_1368.ECDH10B_0985,iPC815.YPO1396	Bacteria	1MU8G@1224,1RMMW@1236,COG1663@1,COG1663@2	NA|NA|NA	F	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)
C1_02306	155864.EDL933_1177	0.0	1097.4	Escherichia	msbA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0006869,GO:0008144,GO:0008150,GO:0008289,GO:0008559,GO:0009987,GO:0010876,GO:0015221,GO:0015238,GO:0015399,GO:0015405,GO:0015437,GO:0015893,GO:0015920,GO:0016020,GO:0016021,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0034040,GO:0034204,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042802,GO:0042908,GO:0042910,GO:0043167,GO:0043168,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0061024,GO:0065007,GO:0065008,GO:0071702,GO:0071840,GO:0071944,GO:0097035,GO:0097159,GO:0097367,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901265,GO:1901363,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351		ko:K02021,ko:K06147,ko:K11085	ko02010,map02010				ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21		iJN746.PP_4935,iPC815.YPO1395,iUMN146_1321.UM146_12980	Bacteria	1MUBM@1224,1RMUR@1236,3XMVV@561,COG1132@1,COG1132@2	NA|NA|NA	V	Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation
C1_02307	362663.ECP_0924	0.0	1521.1	Escherichia	ycaI	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02238		M00429			ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2			Bacteria	1MUKF@1224,1RMW6@1236,3XNAX@561,COG0658@1,COG0658@2,COG2333@1,COG2333@2	NA|NA|NA	S	establishment of competence for transformation
C1_02308	1440052.EAKF1_ch0545c	3.8e-47	193.7	Escherichia	himD	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2001141		ko:K05788					ko00000,ko03032,ko03036,ko03400				Bacteria	1MZ7M@1224,1S8XZ@1236,3XPWM@561,COG0776@1,COG0776@2	NA|NA|NA	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control
C1_02309	1440052.EAKF1_ch0546c	2.3e-311	1073.5	Escherichia	rpsA	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0016043,GO:0017148,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113,GO:2000765,GO:2000766	1.17.7.4	ko:K02945,ko:K03527	ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010	M00096,M00178	R05884,R08210	RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko03011				Bacteria	1MVAV@1224,1RMFY@1236,3XMK6@561,COG0539@1,COG0539@2	NA|NA|NA	J	acts as an RNA chaperone to unfold structured mRNA on the ribosome but is not essential for mRNAs with strong SDs and little 5'-UTR structure, thus it may help fine-tune which mRNAs that are translated. Unwinds dsRNA by binding to transiently formed ssRNA regions
C1_02310	155864.EDL933_1173	1.5e-118	432.2	Escherichia	cmk	GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0015939,GO:0015940,GO:0015949,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	1.17.7.4,2.5.1.19,2.7.1.26,2.7.4.25,2.7.7.2,6.3.2.1	ko:K00800,ko:K00945,ko:K02945,ko:K03527,ko:K03977,ko:K11753,ko:K13799	ko00240,ko00400,ko00410,ko00740,ko00770,ko00900,ko01100,ko01110,ko01130,ko01230,ko03010,map00240,map00400,map00410,map00740,map00770,map00900,map01100,map01110,map01130,map01230,map03010	M00022,M00052,M00096,M00119,M00125,M00178	R00158,R00161,R00512,R00549,R01665,R02473,R03460,R05884,R08210	RC00002,RC00017,RC00096,RC00141,RC00350,RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko03009,ko03011			iPC815.YPO1391,iSDY_1059.SDY_2348	Bacteria	1MUUD@1224,1RNKT@1236,3XN6Y@561,COG0283@1,COG0283@2	NA|NA|NA	F	Belongs to the cytidylate kinase family. Type 1 subfamily
C1_02311	198214.SF0905	1.7e-134	485.3	Gammaproteobacteria	ycaL	GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564		ko:K07387					ko00000,ko01000,ko01002				Bacteria	1NK9F@1224,1RQSJ@1236,COG0501@1,COG0501@2	NA|NA|NA	O	metalloprotease
C1_02312	155864.EDL933_1171	4.6e-241	840.1	Escherichia	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000			iEC042_1314.EC042_0998,iECNA114_1301.ECNA114_0940,iECSF_1327.ECSF_0829,iPC815.YPO1390	Bacteria	1MWMK@1224,1RQ8U@1236,3XMZC@561,COG0128@1,COG0128@2	NA|NA|NA	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
C1_02313	198214.SF0902	3e-209	734.2	Gammaproteobacteria	serC	GO:0003674,GO:0003824,GO:0004648,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006520,GO:0006553,GO:0006563,GO:0006564,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009085,GO:0009089,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019752,GO:0019842,GO:0030170,GO:0033359,GO:0034641,GO:0036094,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046394,GO:0046451,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901615,GO:1901617	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007			iEcE24377_1341.EcE24377A_1004,iPC815.YPO1389,iYL1228.KPN_00935	Bacteria	1MUB5@1224,1RMKU@1236,COG1932@1,COG1932@2	NA|NA|NA	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C1_02314	316407.4062480	1.4e-124	452.2	Escherichia	ycaP												Bacteria	1MW5I@1224,1RS6M@1236,3XPE8@561,COG2323@1,COG2323@2	NA|NA|NA	S	Protein of unknown function (DUF421)
C1_02315	316407.85674788	0.0	1184.9	Escherichia	ycaO	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018193,GO:0018197,GO:0018198,GO:0018339,GO:0019538,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0047429,GO:0047693,GO:0071704,GO:1901564		ko:K09136					ko00000,ko03009				Bacteria	1MV7K@1224,1RN47@1236,3XNVF@561,COG1944@1,COG1944@2	NA|NA|NA	S	ATP diphosphatase activity
C1_02316	155864.EDL933_1167	1.4e-158	565.5	Escherichia	focA	GO:0003674,GO:0005215,GO:0005342,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0008028,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015238,GO:0015318,GO:0015499,GO:0015711,GO:0015718,GO:0015724,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0042802,GO:0042891,GO:0042895,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098656,GO:1903825,GO:1905039		ko:K02598,ko:K03459,ko:K06212,ko:K21990,ko:K21993					ko00000,ko02000	1.A.16.1.1,1.A.16.1.2,1.A.16.1.3,1.A.16.2,1.A.16.3,1.A.16.4		iECIAI39_1322.ECIAI39_2632,iEcSMS35_1347.EcSMS35_2639,iSF_1195.SF0899,iS_1188.S0963	Bacteria	1MU0W@1224,1RQ6K@1236,3XN70@561,COG2116@1,COG2116@2	NA|NA|NA	P	Involved in the bidirectional transport of formate
C1_02317	316407.1651427	0.0	1524.2	Escherichia	pflB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006566,GO:0006567,GO:0006629,GO:0006631,GO:0006807,GO:0008150,GO:0008152,GO:0008861,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009987,GO:0016020,GO:0016054,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0016999,GO:0017144,GO:0019541,GO:0019752,GO:0032787,GO:0042737,GO:0043436,GO:0043875,GO:0044237,GO:0044238,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046459,GO:0070689,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120		R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000			iECH74115_1262.ECH74115_1064,iECIAI39_1322.ECIAI39_2245,iECSP_1301.ECSP_1007,iECs_1301.ECs0986,iEcSMS35_1347.EcSMS35_2218,iEcSMS35_1347.EcSMS35_3410,iG2583_1286.G2583_1138,iSDY_1059.SDY_2358,iZ_1308.Z1248	Bacteria	1MWBF@1224,1RM96@1236,3XMX2@561,COG1882@1,COG1882@2	NA|NA|NA	C	formate C-acetyltransferase activity
C1_02318	155864.EDL933_1165	4.2e-146	523.9	Escherichia	pflA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0018307,GO:0019538,GO:0033554,GO:0036211,GO:0043170,GO:0043364,GO:0043365,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0055114,GO:0070283,GO:0071704,GO:1901564	1.97.1.4	ko:K04069			R04710		ko00000,ko01000			iECOK1_1307.ECOK1_0925,iEcE24377_1341.EcE24377A_0980,iEcSMS35_1347.EcSMS35_2219,iYL1228.KPN_00930	Bacteria	1NQC1@1224,1RNCR@1236,3XNPM@561,COG1180@1,COG1180@2	NA|NA|NA	O	under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C1_02319	316407.4062477	8.2e-113	412.9	Gammaproteobacteria	ycaK	GO:0000166,GO:0003674,GO:0003824,GO:0003955,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008150,GO:0008152,GO:0008753,GO:0009055,GO:0009987,GO:0010181,GO:0016491,GO:0016651,GO:0016655,GO:0022898,GO:0022900,GO:0032409,GO:0032411,GO:0032412,GO:0032414,GO:0032553,GO:0032879,GO:0034762,GO:0034764,GO:0034765,GO:0034767,GO:0036094,GO:0043167,GO:0043168,GO:0043269,GO:0043270,GO:0044093,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0048518,GO:0050660,GO:0050662,GO:0050789,GO:0051049,GO:0051050,GO:0055114,GO:0065007,GO:0065009,GO:0097159,GO:0097367,GO:1901265,GO:1901363	1.6.5.2	ko:K00355,ko:K03923,ko:K11746,ko:K11748	ko00130,ko01110,ko05200,ko05225,ko05418,map00130,map01110,map05200,map05225,map05418		R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000,ko02000	2.A.37.1.1,2.A.37.1.2		iLF82_1304.LF82_1283	Bacteria	1MUHN@1224,1S24D@1236,COG2249@1,COG2249@2	NA|NA|NA	S	NAD(P)H dehydrogenase (quinone)
C1_02320	316407.4062476	3.3e-169	600.9	Escherichia	ycaN	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141											Bacteria	1MU2E@1224,1RYV3@1236,3XQZP@561,COG0583@1,COG0583@2	NA|NA|NA	K	sequence-specific DNA binding
C1_02321	316407.85674787	2.6e-269	934.1	Escherichia	ycaM	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0006873,GO:0006885,GO:0008150,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015171,GO:0015179,GO:0015291,GO:0015297,GO:0015318,GO:0015711,GO:0015807,GO:0015849,GO:0016020,GO:0016021,GO:0019725,GO:0022804,GO:0022857,GO:0030003,GO:0030004,GO:0030641,GO:0031224,GO:0031226,GO:0034220,GO:0042592,GO:0044425,GO:0044459,GO:0044464,GO:0045852,GO:0046942,GO:0046943,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0051453,GO:0051454,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:0098771,GO:1902475,GO:1903825,GO:1905039		ko:K20265	ko02024,map02024				ko00000,ko00001,ko02000	2.A.3.7.1,2.A.3.7.3		iEC042_1314.EC042_1624	Bacteria	1MVTW@1224,1S0DS@1236,3XQKH@561,COG0531@1,COG0531@2	NA|NA|NA	P	transmembrane transporter activity
C1_02322	316407.4062472	7.4e-203	713.0	Escherichia	ycaD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K08219					ko00000,ko02000	2.A.1.26			Bacteria	1QTUM@1224,1T1HT@1236,3XNEZ@561,COG0477@1,COG0477@2	NA|NA|NA	EGP	MFS-type transporter YcaD
C1_02323	155864.EDL933_1161	8.5e-116	422.9	Escherichia	ycaC	GO:0003674,GO:0005488,GO:0005515,GO:0042802											Bacteria	1MWFQ@1224,1RMHF@1236,3XNGI@561,COG1335@1,COG1335@2	NA|NA|NA	Q	lyase activity
C1_02324	155864.EDL933_1160	1.4e-153	548.9	Escherichia	dmsC	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009389,GO:0009390,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016667,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0055114,GO:0071944,GO:1902494		ko:K07308,ko:K07312	ko00920,map00920		R09501	RC02555	ko00000,ko00001,ko02000	5.A.3.3		iECO111_1330.ECO111_0964,iECO26_1355.ECO26_1022,iUTI89_1310.UTI89_C0969	Bacteria	1PA8U@1224,1RRGH@1236,3XP9S@561,COG3302@1,COG3302@2	NA|NA|NA	S	Dimethyl sulfoxide reductase
C1_02325	1440052.EAKF1_ch0575c	7.5e-125	453.0	Escherichia	dmsB	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009389,GO:0009390,GO:0009897,GO:0009986,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016667,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071944,GO:0098552,GO:0098567,GO:1902494		ko:K07307,ko:K07311	ko00920,map00920		R09501	RC02555	ko00000,ko00001,ko02000	5.A.3.3		iPC815.YPO3324	Bacteria	1MU5T@1224,1RPIC@1236,3XPBX@561,COG0437@1,COG0437@2	NA|NA|NA	C	Anaerobic dimethyl sulfoxide reductase chain B
C1_02326	316407.85674786	0.0	1667.9	Escherichia	dmsA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009390,GO:0009897,GO:0009986,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0022900,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0032991,GO:0033797,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071944,GO:0098552,GO:0098567,GO:1902494	1.8.5.3,1.97.1.9	ko:K07306,ko:K07309,ko:K07310	ko00450,ko00920,map00450,map00920		R07229,R09501	RC02420,RC02555	ko00000,ko00001,ko01000,ko02000	5.A.3.3		iE2348C_1286.E2348C_1672,iECSE_1348.ECSE_0952,iNRG857_1313.NRG857_07945,iZ_1308.Z1240	Bacteria	1NR6J@1224,1RMVE@1236,3XN4H@561,COG0243@1,COG0243@2	NA|NA|NA	C	Dimethyl sulfoxide reductase
C1_02327	155864.EDL933_1157	5.1e-240	836.6	Escherichia	serS	GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004828,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006434,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009059,GO:0009069,GO:0009070,GO:0009987,GO:0010467,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iAF987.Gmet_3528,iSDY_1059.SDY_2368	Bacteria	1MUJF@1224,1RNAQ@1236,3XM4W@561,COG0172@1,COG0172@2	NA|NA|NA	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C1_02328	1440052.EAKF1_ch0578c	2.4e-253	880.9	Escherichia	rarA	GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0030894,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576		ko:K07478					ko00000				Bacteria	1MUVS@1224,1RPBY@1236,3XM8Q@561,COG2256@1,COG2256@2	NA|NA|NA	L	DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes
C1_02329	155864.EDL933_1155	2.7e-111	407.9	Escherichia	lolA	GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0030288,GO:0030313,GO:0031975,GO:0032940,GO:0033036,GO:0034613,GO:0042597,GO:0042886,GO:0042953,GO:0042954,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0051641,GO:0070727,GO:0071702,GO:0071705,GO:0072321,GO:0072322,GO:0072323,GO:0072657		ko:K03634					ko00000				Bacteria	1PXDV@1224,1S9FW@1236,3XNMD@561,COG2834@1,COG2834@2	NA|NA|NA	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C1_02330	198214.SF0849	0.0	2206.8	Gammaproteobacteria	ftsK	GO:0000920,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006950,GO:0006970,GO:0007059,GO:0008094,GO:0008150,GO:0009628,GO:0009651,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0015616,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033676,GO:0042221,GO:0042623,GO:0042802,GO:0043085,GO:0043565,GO:0044093,GO:0044425,GO:0044459,GO:0044464,GO:0045893,GO:0045935,GO:0046677,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051301,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0070887,GO:0071236,GO:0071944,GO:0080090,GO:0097159,GO:0140097,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141		ko:K02011,ko:K02012,ko:K03466	ko02010,map02010	M00190			ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.10,3.A.12			Bacteria	1MVPI@1224,1RM9A@1236,COG1178@1,COG1178@2,COG1674@1,COG1674@2	NA|NA|NA	D	COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins
C1_02331	1440052.EAKF1_ch0581c	5.5e-86	323.6	Escherichia	lrp	GO:0000976,GO:0001067,GO:0001101,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006355,GO:0006520,GO:0006522,GO:0006524,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009078,GO:0009080,GO:0009081,GO:0009082,GO:0009098,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016053,GO:0016054,GO:0019219,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0042221,GO:0042802,GO:0043200,GO:0043201,GO:0043436,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046394,GO:0046395,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1901698,GO:1901700,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K03719,ko:K05800					ko00000,ko03000,ko03036				Bacteria	1MX7R@1224,1RPGA@1236,3XMYH@561,COG1522@1,COG1522@2	NA|NA|NA	K	lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes
C1_02332	199310.c1025	8e-182	642.9	Escherichia	trxB	GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748	1.8.1.9	ko:K00384,ko:K03671	ko00450,ko04621,ko05418,map00450,map04621,map05418		R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko03110			iNJ661.Rv3913,iPC815.YPO1374	Bacteria	1MV15@1224,1RMEX@1236,3XNJ5@561,COG0492@1,COG0492@2	NA|NA|NA	O	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
C1_02333	155864.EDL933_1150	0.0	1125.9	Escherichia	cydD	GO:0000101,GO:0003333,GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006857,GO:0006865,GO:0006869,GO:0008150,GO:0009987,GO:0010876,GO:0015399,GO:0015405,GO:0015711,GO:0015804,GO:0015833,GO:0015849,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019725,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0032973,GO:0032991,GO:0033036,GO:0033228,GO:0034040,GO:0034220,GO:0034635,GO:0034775,GO:0035443,GO:0035672,GO:0042592,GO:0042623,GO:0042626,GO:0042883,GO:0042886,GO:0042939,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0045454,GO:0046942,GO:0050789,GO:0050794,GO:0051179,GO:0051181,GO:0051234,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0072348,GO:0098533,GO:0098655,GO:0098656,GO:0098796,GO:0098797,GO:0140115,GO:1902494,GO:1902495,GO:1903712,GO:1903825,GO:1904949,GO:1905039,GO:1990351		ko:K16013	ko02010,map02010				ko00000,ko00001,ko02000	3.A.1.129		iEC042_1314.EC042_0979,iECUMN_1333.ECUMN_1082,iETEC_1333.ETEC_0955	Bacteria	1QU1N@1224,1RNPI@1236,3XMAN@561,COG4988@1,COG4988@2	NA|NA|NA	P	ATP-binding
C1_02334	469008.B21_00897	2.4e-309	1067.4	Escherichia	cydC	GO:0000101,GO:0003333,GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006857,GO:0006865,GO:0008150,GO:0009889,GO:0015399,GO:0015405,GO:0015711,GO:0015804,GO:0015833,GO:0015849,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019222,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0031323,GO:0031326,GO:0032973,GO:0032991,GO:0033228,GO:0034220,GO:0034635,GO:0034775,GO:0035443,GO:0035672,GO:0042623,GO:0042626,GO:0042883,GO:0042886,GO:0042939,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0050789,GO:0050794,GO:0051171,GO:0051179,GO:0051181,GO:0051193,GO:0051234,GO:0055085,GO:0065007,GO:0070453,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0072348,GO:0098533,GO:0098655,GO:0098656,GO:0098796,GO:0098797,GO:0140115,GO:1901401,GO:1901463,GO:1902494,GO:1902495,GO:1903712,GO:1903825,GO:1904949,GO:1905039,GO:1990351		ko:K16012	ko02010,map02010				ko00000,ko00001,ko02000	3.A.1.129		iEC55989_1330.EC55989_0931,iECIAI1_1343.ECIAI1_0926,iECO103_1326.ECO103_0929,iECO111_1330.ECO111_0954,iECSE_1348.ECSE_0944,iECW_1372.ECW_m0996,iEKO11_1354.EKO11_2951,iSDY_1059.SDY_2375,iWFL_1372.ECW_m0996	Bacteria	1QU1P@1224,1RQD7@1236,3XNCD@561,COG4987@1,COG4987@2	NA|NA|NA	P	ATP-binding
C1_02335	198214.SF0844	4.7e-139	500.4	Gammaproteobacteria	aat	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008914,GO:0016740,GO:0016746,GO:0016755,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0071704,GO:0140096,GO:1901564	2.3.2.6	ko:K00684			R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000				Bacteria	1R9W8@1224,1S1ZB@1236,COG2360@1,COG2360@2	NA|NA|NA	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C1_02336	1005994.GTGU_01094	5.3e-33	146.4	Gammaproteobacteria	infA	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576		ko:K02518					ko00000,ko03012				Bacteria	1MZFU@1224,1S8WZ@1236,COG0361@1,COG0361@2	NA|NA|NA	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C1_02338	1051646.VITU9109_00560	8e-58	231.5	Vibrionales													Bacteria	1N73Z@1224,1SEHI@1236,1XTD7@135623,COG0582@1,COG0582@2	NA|NA|NA	L	Belongs to the 'phage' integrase family
C1_02339	223926.28807129	6.6e-45	188.3	Vibrionales				ko:K03733,ko:K14059					ko00000,ko03036				Bacteria	1MVZB@1224,1RSCD@1236,1XW86@135623,COG0582@1,COG0582@2	NA|NA|NA	L	Phage integrase family
C1_02340	644801.Psest_0916	1.4e-40	173.7	Pseudomonas stutzeri group													Bacteria	1QSA2@1224,1SQDK@1236,1Z2ND@136846,2AW8Q@1,31N3Z@2	NA|NA|NA		
C1_02341	342610.Patl_0683	9.4e-13	79.3	Gammaproteobacteria													Bacteria	1P4C4@1224,1SVVY@1236,28S35@1,2ZEEX@2	NA|NA|NA		
C1_02342	558884.JRGM01000050_gene21	2.3e-206	724.9	Aeromonadales													Bacteria	1MVGK@1224,1S6W2@1236,1Y6BX@135624,COG5545@1,COG5545@2	NA|NA|NA	S	Virulence-associated protein E
C1_02343	1504981.KO116_2045	3.9e-69	268.5	Gammaproteobacteria													Bacteria	1RJRP@1224,1T3XT@1236,COG4127@1,COG4127@2	NA|NA|NA	S	FRG
C1_02344	1202962.KB907150_gene1908	1.1e-53	216.5	Gammaproteobacteria													Bacteria	1NZK1@1224,1SPSA@1236,2FA6I@1,342F8@2	NA|NA|NA		
C1_02345	266265.Bxe_A2438	3.8e-16	91.7	Proteobacteria													Bacteria	1NGV2@1224,2EKCB@1,33E2M@2	NA|NA|NA		
C1_02346	234831.PSM_A1330	5.7e-60	237.3	Gammaproteobacteria													Bacteria	1NZGF@1224,1SQFW@1236,2F9YE@1,3427P@2	NA|NA|NA		
C1_02347	155864.EDL933_1016	0.0	1467.2	Escherichia	clpA	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564		ko:K03694					ko00000,ko03110				Bacteria	1MV8B@1224,1RMH3@1236,3XNJY@561,COG0542@1,COG0542@2	NA|NA|NA	O	ATP-dependent specificity component of the ClpAP protease. It directs the protease to specific substrates. It has unfoldase activity. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins
C1_02348	155864.EDL933_1015	2.7e-54	217.6	Escherichia	clpS	GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0050896,GO:0051087		ko:K06891					ko00000				Bacteria	1MZU8@1224,1S8Z7@1236,3XPPB@561,COG2127@1,COG2127@2	NA|NA|NA	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C1_02349	1440052.EAKF1_ch0591	2.4e-36	157.5	Escherichia	cspD	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006275,GO:0006355,GO:0006950,GO:0008150,GO:0008156,GO:0009266,GO:0009409,GO:0009605,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0009991,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031667,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2000113,GO:2001141		ko:K03704					ko00000,ko03000				Bacteria	1N6Q5@1224,1SCA7@1236,3XPZU@561,COG1278@1,COG1278@2	NA|NA|NA	K	Inhibits DNA replication at both initiation and elongation steps, most probably by binding to the opened, single- stranded regions at replication forks. Plays a regulatory role in chromosomal replication in nutrient-depleted cells
C1_02350	469008.B21_00890	0.0	1235.3	Escherichia	macB	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0008144,GO:0008150,GO:0008559,GO:0015238,GO:0015399,GO:0015405,GO:0015893,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042802,GO:0042891,GO:0042895,GO:0042908,GO:0042910,GO:0043167,GO:0043168,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046618,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:1901265,GO:1901363,GO:1902495,GO:1990195,GO:1990196,GO:1990351		ko:K02003,ko:K02004,ko:K05685	ko02010,map02010	M00258,M00709			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12			Bacteria	1MU45@1224,1RNUJ@1236,3XNDE@561,COG0577@1,COG0577@2,COG1136@1,COG1136@2	NA|NA|NA	V	Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation
C1_02351	481805.EcolC_2718	5.1e-196	690.3	Escherichia	macA	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015238,GO:0015893,GO:0016020,GO:0016021,GO:0019898,GO:0022857,GO:0031224,GO:0032991,GO:0042221,GO:0042493,GO:0042802,GO:0042891,GO:0042895,GO:0044425,GO:0044464,GO:0046618,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098796,GO:1902495,GO:1990195,GO:1990196,GO:1990351		ko:K02005,ko:K13888		M00709			ko00000,ko00002,ko02000	8.A.1			Bacteria	1MU8D@1224,1RN0E@1236,3XNFK@561,COG0845@1,COG0845@2	NA|NA|NA	M	Part of the tripartite efflux system MacAB-TolC. MacA stimulates the ATPase activity of MacB by promoting the closed ATP-bound state of MacB, increases the capacity of MacB to bind macrolides such as erythromycin, and provides a physical link between MacB and TolC
C1_02352	198214.SF0836	2.7e-185	654.4	Gammaproteobacteria	ybjX	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716		ko:K09824					ko00000				Bacteria	1NTXF@1224,1RPKK@1236,COG2990@1,COG2990@2	NA|NA|NA	S	protein conserved in bacteria
C1_02353	198214.SF0835	0.0	1103.6	Gammaproteobacteria	ybjD	GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576		ko:K07459					ko00000				Bacteria	1N2CB@1224,1RQN2@1236,COG3593@1,COG3593@2	NA|NA|NA	L	ATP-dependent endonuclease of the OLD family
C1_02354	198214.SF0832	1.4e-122	445.7	Gammaproteobacteria	aqpZ	GO:0003674,GO:0005215,GO:0005372,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006833,GO:0006884,GO:0006950,GO:0006970,GO:0008150,GO:0008361,GO:0009628,GO:0009987,GO:0009992,GO:0015250,GO:0015267,GO:0015318,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022838,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0042044,GO:0042592,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0050896,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066		ko:K02440,ko:K06188					ko00000,ko02000	1.A.8,1.A.8.1,1.A.8.2		iAF1260.b3927,iAPECO1_1312.APECO1_2542,iB21_1397.B21_03761,iBWG_1329.BWG_3596,iEC042_1314.EC042_4301,iEC55989_1330.EC55989_4405,iECABU_c1320.ECABU_c44330,iECBD_1354.ECBD_4097,iECB_1328.ECB_03812,iECDH10B_1368.ECDH10B_4116,iECDH1ME8569_1439.ECDH1ME8569_3796,iECD_1391.ECD_03812,iECED1_1282.ECED1_4629,iECH74115_1262.ECH74115_5382,iECIAI1_1343.ECIAI1_4132,iECNA114_1301.ECNA114_4066,iECO103_1326.ECO103_4601,iECO111_1330.ECO111_4750,iECO26_1355.ECO26_4658,iECOK1_1307.ECOK1_4395,iECP_1309.ECP_4136,iECS88_1305.ECS88_4377,iECSE_1348.ECSE_4216,iECSF_1327.ECSF_3787,iECSP_1301.ECSP_4990,iECUMN_1333.ECUMN_4455,iECW_1372.ECW_m4279,iECs_1301.ECs4852,iEKO11_1354.EKO11_4388,iETEC_1333.ETEC_4196,iEcDH1_1363.EcDH1_4058,iEcE24377_1341.EcE24377A_4461,iEcSMS35_1347.EcSMS35_4367,iEcolC_1368.EcolC_4091,iG2583_1286.G2583_4732,iJN678.apqZ,iJO1366.b3927,iJR904.b3927,iLF82_1304.LF82_0868,iNRG857_1313.NRG857_19605,iSSON_1240.SSON_4096,iUMNK88_1353.UMNK88_4764,iUTI89_1310.UTI89_C4511,iWFL_1372.ECW_m4279,iY75_1357.Y75_RS17425,iZ_1308.Z5472,ic_1306.c4879	Bacteria	1MXTJ@1224,1RPKU@1236,COG0580@1,COG0580@2	NA|NA|NA	G	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity
C1_02355	316407.4062453	3e-154	551.2	Escherichia	ybjE	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015174,GO:0015179,GO:0015189,GO:0015238,GO:0015318,GO:0015562,GO:0015661,GO:0015711,GO:0015802,GO:0015807,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0034639,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902022,GO:1902475,GO:1903401,GO:1903825,GO:1905039,GO:1990822											Bacteria	1MYMF@1224,1RP7N@1236,3XNZ1@561,COG2431@1,COG2431@2	NA|NA|NA	S	L-lysine efflux transmembrane transporter activity
C1_02356	155864.EDL933_1007	0.0	1120.5	Escherichia	hcp	GO:0000302,GO:0001505,GO:0003674,GO:0003824,GO:0004601,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016661,GO:0016684,GO:0017144,GO:0034641,GO:0042133,GO:0042135,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0044237,GO:0044248,GO:0044270,GO:0046209,GO:0046210,GO:0046677,GO:0050418,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1990748,GO:2001057	1.7.99.1	ko:K05601	ko00910,map00910		R00143	RC02797	ko00000,ko00001,ko01000				Bacteria	1N88B@1224,1RP1I@1236,3XNJ6@561,COG0369@1,COG1151@2	NA|NA|NA	C	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O
C1_02357	316407.85674783	1.9e-186	658.3	Escherichia	hcr	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050662,GO:0051536,GO:0051537,GO:0051540,GO:0055114,GO:0097159,GO:1901265,GO:1901363		ko:K11933					ko00000,ko01000				Bacteria	1MY2Q@1224,1RR5A@1236,3XMND@561,COG1018@1,COG1018@2	NA|NA|NA	C	NADH oxidoreductase
C1_02358	155864.EDL933_1005	0.0	1129.8	Escherichia	poxB	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006090,GO:0008150,GO:0008152,GO:0008289,GO:0009056,GO:0009987,GO:0016020,GO:0016043,GO:0016054,GO:0016491,GO:0016903,GO:0019752,GO:0019842,GO:0022607,GO:0030976,GO:0032787,GO:0036094,GO:0042802,GO:0042867,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046872,GO:0048037,GO:0050660,GO:0050662,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0052737,GO:0052738,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575,GO:1901681	1.2.3.3,1.2.5.1	ko:K00156,ko:K00158	ko00620,ko01100,map00620,map01100		R00207,R03145	RC00860,RC02745	ko00000,ko00001,ko01000			iSF_1195.SF0826,iSFxv_1172.SFxv_0895,iS_1188.S0867	Bacteria	1MWKP@1224,1RNYT@1236,3XNU3@561,COG0028@1,COG0028@2	NA|NA|NA	C	Belongs to the TPP enzyme family
C1_02359	481805.EcolC_2726	8.6e-187	659.4	Escherichia	ltaE	GO:0003674,GO:0003824,GO:0004793,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006566,GO:0006567,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008732,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016832,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0048037,GO:0050179,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230		R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000			iECNA114_1301.ECNA114_0812,iECSF_1327.ECSF_0795	Bacteria	1MWCR@1224,1RNYX@1236,3XN44@561,COG2008@1,COG2008@2	NA|NA|NA	E	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde. L-threo-phenylserine and L- erythro-phenylserine are also good substrates
C1_02360	316407.85674782	2.3e-278	964.1	Escherichia	ybjT	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1MW54@1224,1RNS7@1236,3XNJ2@561,COG0702@1,COG0702@2	NA|NA|NA	GM	Protein of unknown function (DUF2867)
C1_02361	155864.EDL933_1002	1.5e-194	685.3	Escherichia	ybjS		1.1.1.133,5.1.3.13	ko:K00067,ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777,R06514	RC00182,RC01531	ko00000,ko00001,ko00002,ko01000				Bacteria	1P603@1224,1RQ2R@1236,3XNMN@561,COG0451@1,COG0451@2	NA|NA|NA	M	coenzyme binding
C1_02362	155864.EDL933_1001	1.1e-158	565.8	Escherichia	amiD	GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008745,GO:0009056,GO:0009057,GO:0009253,GO:0009254,GO:0009392,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0019867,GO:0030203,GO:0043167,GO:0043169,GO:0043170,GO:0046872,GO:0046914,GO:0061783,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575	3.5.1.28	ko:K03806,ko:K11066					ko00000,ko01000,ko01011			iAF1260.b0110,iB21_1397.B21_00108,iBWG_1329.BWG_0103,iEC55989_1330.EC55989_0103,iECBD_1354.ECBD_3509,iECB_1328.ECB_00109,iECDH10B_1368.ECDH10B_0090,iECDH1ME8569_1439.ECDH1ME8569_0104,iECD_1391.ECD_00109,iECIAI1_1343.ECIAI1_0107,iECO103_1326.ECO103_0110,iECO111_1330.ECO111_0111,iECO26_1355.ECO26_0112,iECSE_1348.ECSE_0110,iECW_1372.ECW_m0107,iEKO11_1354.EKO11_3806,iETEC_1333.ETEC_0106,iEcDH1_1363.EcDH1_3492,iEcE24377_1341.EcE24377A_0112,iEcHS_1320.EcHS_A0114,iEcolC_1368.EcolC_3549,iJO1366.b0110,iUMNK88_1353.UMNK88_108,iWFL_1372.ECW_m0107,iY75_1357.Y75_RS00560	Bacteria	1RDHU@1224,1RMDN@1236,3XNYK@561,COG3023@1,COG3023@2	NA|NA|NA	V	N-acetyl-anhydromuramoyl-L-alanine amidase activity
C1_02363	155864.EDL933_1000	1.7e-51	208.4	Escherichia	ybjQ												Bacteria	1N0XM@1224,1S62I@1236,3XPSK@561,COG0393@1,COG0393@2	NA|NA|NA	S	Belongs to the UPF0145 family
C1_02364	316407.4062445	7e-92	343.2	Escherichia	ybjP												Bacteria	1R5ZY@1224,1RRXU@1236,29BUY@1,2ZYT8@2,3XPJQ@561	NA|NA|NA	M	Protein of unknown function (DUF3828)
C1_02365	155864.EDL933_0997	1.5e-132	478.8	Escherichia	artP	GO:0003333,GO:0003674,GO:0003824,GO:0005215,GO:0005275,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015318,GO:0015399,GO:0015405,GO:0015424,GO:0015426,GO:0015711,GO:0015802,GO:0015807,GO:0015809,GO:0015837,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0031224,GO:0031263,GO:0032991,GO:0033283,GO:0033284,GO:0034220,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0043090,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055052,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0089718,GO:0097638,GO:0098533,GO:0098655,GO:0098656,GO:0098657,GO:0098739,GO:0098796,GO:0098797,GO:1902023,GO:1902475,GO:1902494,GO:1902495,GO:1903400,GO:1903825,GO:1903826,GO:1904949,GO:1905039,GO:1990351,GO:1990822		ko:K10000	ko02010,map02010	M00229			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3.3		iAF1260.b0864,iB21_1397.B21_00875,iBWG_1329.BWG_0717,iE2348C_1286.E2348C_0861,iEC042_1314.EC042_0955,iEC55989_1330.EC55989_0909,iECABU_c1320.ECABU_c09050,iECBD_1354.ECBD_2730,iECB_1328.ECB_00869,iECDH10B_1368.ECDH10B_0934,iECD_1391.ECD_00869,iECED1_1282.ECED1_0829,iECH74115_1262.ECH74115_1024,iECIAI1_1343.ECIAI1_0903,iECIAI39_1322.ECIAI39_0844,iECNA114_1301.ECNA114_0806,iECO111_1330.ECO111_0933,iECO26_1355.ECO26_0991,iECOK1_1307.ECOK1_0866,iECP_1309.ECP_0879,iECS88_1305.ECS88_0882,iECSE_1348.ECSE_0922,iECSF_1327.ECSF_0789,iECSP_1301.ECSP_0967,iECUMN_1333.ECUMN_1057,iECs_1301.ECs0947,iETEC_1333.ETEC_0931,iEcDH1_1363.EcDH1_2778,iEcE24377_1341.EcE24377A_0937,iEcHS_1320.EcHS_A0968,iEcSMS35_1347.EcSMS35_0892,iEcolC_1368.EcolC_2732,iG2583_1286.G2583_1098,iJO1366.b0864,iJR904.b0864,iLF82_1304.LF82_0156,iNRG857_1313.NRG857_03900,iPC815.YPO1352,iSBO_1134.SBO_0798,iSFV_1184.SFV_0849,iSF_1195.SF0818,iSFxv_1172.SFxv_0886,iSSON_1240.SSON_0849,iS_1188.S0860,iSbBS512_1146.SbBS512_E2467,iUMN146_1321.UM146_13330,iY75_1357.Y75_RS04495,iYL1228.KPN_00897,iZ_1308.Z1094,ic_1306.c0997	Bacteria	1MU9Q@1224,1RMB1@1236,3XN1Y@561,COG1126@1,COG1126@2	NA|NA|NA	P	Part of the ABC transporter complex ArtPIQMJ involved in arginine transport. Probably responsible for energy coupling to the transport system
C1_02366	316407.1651396	8e-134	483.0	Escherichia	artI	GO:0003333,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0015711,GO:0015802,GO:0015807,GO:0015809,GO:0015849,GO:0015893,GO:0016597,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0034220,GO:0034618,GO:0036094,GO:0042221,GO:0042493,GO:0042597,GO:0043090,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044464,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0089718,GO:0097638,GO:0098655,GO:0098656,GO:0098657,GO:0098739,GO:1902023,GO:1902475,GO:1903400,GO:1903825,GO:1903826,GO:1905039,GO:1990822		ko:K09996,ko:K09997	ko02010,map02010	M00229			ko00000,ko00001,ko00002,ko02000	3.A.1.3.3		iLF82_1304.LF82_0153,iNRG857_1313.NRG857_03895,iPC815.YPO1351,iUMN146_1321.UM146_13350	Bacteria	1MXIA@1224,1RPXK@1236,3XNZG@561,COG0834@1,COG0834@2	NA|NA|NA	ET	Belongs to the bacterial solute-binding protein 3 family
C1_02367	198214.SF0816	5.1e-125	453.8	Gammaproteobacteria	artQ	GO:0003333,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0015711,GO:0015802,GO:0015807,GO:0015809,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0043090,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0089718,GO:0097638,GO:0098655,GO:0098656,GO:0098657,GO:0098739,GO:1902023,GO:1902475,GO:1903400,GO:1903825,GO:1903826,GO:1905039,GO:1990822		ko:K02029,ko:K09999	ko02010,map02010	M00229,M00236			ko00000,ko00001,ko00002,ko02000	3.A.1.3,3.A.1.3.3		iAF1260.b0862,iB21_1397.B21_00873,iBWG_1329.BWG_0715,iE2348C_1286.E2348C_0859,iEC55989_1330.EC55989_0907,iECABU_c1320.ECABU_c09030,iECBD_1354.ECBD_2732,iECB_1328.ECB_00867,iECDH10B_1368.ECDH10B_0932,iECDH1ME8569_1439.ECDH1ME8569_0814,iECD_1391.ECD_00867,iECH74115_1262.ECH74115_1022,iECIAI1_1343.ECIAI1_0901,iECIAI39_1322.ECIAI39_0842,iECNA114_1301.ECNA114_0804,iECO103_1326.ECO103_0906,iECO111_1330.ECO111_0931,iECO26_1355.ECO26_0989,iECSE_1348.ECSE_0920,iECSF_1327.ECSF_0787,iECSP_1301.ECSP_0965,iECW_1372.ECW_m0970,iECs_1301.ECs0945,iEKO11_1354.EKO11_2974,iETEC_1333.ETEC_0929,iEcDH1_1363.EcDH1_2780,iEcE24377_1341.EcE24377A_0935,iEcHS_1320.EcHS_A0966,iEcSMS35_1347.EcSMS35_0890,iEcolC_1368.EcolC_2734,iG2583_1286.G2583_1096,iJO1366.b0862,iJR904.b0862,iLF82_1304.LF82_0157,iNRG857_1313.NRG857_03890,iSBO_1134.SBO_0796,iSFV_1184.SFV_0847,iSF_1195.SF0816,iSFxv_1172.SFxv_0884,iSSON_1240.SSON_0847,iS_1188.S0858,iUMNK88_1353.UMNK88_958,iWFL_1372.ECW_m0970,iY75_1357.Y75_RS04485,iZ_1308.Z1092,ic_1306.c0995	Bacteria	1NH6Q@1224,1RPY2@1236,COG4215@1,COG4215@2	NA|NA|NA	P	arginine transporter permease subunit ArtQ
C1_02368	155864.EDL933_0994	3.8e-106	391.0	Escherichia	artM	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015318,GO:0015711,GO:0015802,GO:0015807,GO:0015809,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0043090,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0089718,GO:0097638,GO:0098655,GO:0098656,GO:0098657,GO:0098739,GO:1902023,GO:1902475,GO:1903400,GO:1903825,GO:1903826,GO:1905039,GO:1990822		ko:K02029,ko:K09998	ko02010,map02010	M00229,M00236			ko00000,ko00001,ko00002,ko02000	3.A.1.3,3.A.1.3.3		iAF1260.b0861,iAPECO1_1312.APECO1_1232,iB21_1397.B21_00872,iBWG_1329.BWG_0714,iE2348C_1286.E2348C_0858,iEC042_1314.EC042_0952,iEC55989_1330.EC55989_0906,iECABU_c1320.ECABU_c09020,iECBD_1354.ECBD_2733,iECB_1328.ECB_00866,iECDH10B_1368.ECDH10B_0931,iECDH1ME8569_1439.ECDH1ME8569_0813,iECD_1391.ECD_00866,iECED1_1282.ECED1_0826,iECH74115_1262.ECH74115_1021,iECIAI1_1343.ECIAI1_0900,iECIAI39_1322.ECIAI39_0841,iECNA114_1301.ECNA114_0803,iECO103_1326.ECO103_0905,iECO111_1330.ECO111_0930,iECO26_1355.ECO26_0988,iECOK1_1307.ECOK1_0863,iECP_1309.ECP_0876,iECS88_1305.ECS88_0879,iECSE_1348.ECSE_0919,iECSF_1327.ECSF_0786,iECSP_1301.ECSP_0964,iECW_1372.ECW_m0969,iECs_1301.ECs0944,iEKO11_1354.EKO11_2975,iETEC_1333.ETEC_0928,iEcDH1_1363.EcDH1_2781,iEcE24377_1341.EcE24377A_0934,iEcHS_1320.EcHS_A0965,iEcolC_1368.EcolC_2735,iG2583_1286.G2583_1095,iJO1366.b0861,iJR904.b0861,iLF82_1304.LF82_0155,iNRG857_1313.NRG857_03885,iPC815.YPO1349,iSBO_1134.SBO_0795,iSFV_1184.SFV_0846,iSF_1195.SF0815,iSFxv_1172.SFxv_0883,iS_1188.S0857,iSbBS512_1146.SbBS512_E2470,iUMN146_1321.UM146_13345,iUMNK88_1353.UMNK88_957,iUTI89_1310.UTI89_C0864,iWFL_1372.ECW_m0969,iY75_1357.Y75_RS04480,iZ_1308.Z1091,ic_1306.c0994	Bacteria	1QV6B@1224,1RNC2@1236,3XNAT@561,COG4160@1,COG4160@2	NA|NA|NA	P	Part of the ABC transporter complex ArtPIQMJ involved in arginine transport. Probably responsible for the translocation of the substrate across the membrane
C1_02369	199310.c0993	2.5e-135	488.0	Escherichia	artJ	GO:0003333,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0015711,GO:0015802,GO:0015807,GO:0015809,GO:0015849,GO:0015893,GO:0016597,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0034220,GO:0034618,GO:0036094,GO:0042221,GO:0042493,GO:0042597,GO:0043090,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044464,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0089718,GO:0097638,GO:0098655,GO:0098656,GO:0098657,GO:0098739,GO:1902023,GO:1902475,GO:1903400,GO:1903825,GO:1903826,GO:1905039,GO:1990822		ko:K09996,ko:K09997	ko02010,map02010	M00229			ko00000,ko00001,ko00002,ko02000	3.A.1.3.3		iG2583_1286.G2583_1094,iLF82_1304.LF82_0153,iNRG857_1313.NRG857_03895,iUMN146_1321.UM146_13350,iZ_1308.Z1090	Bacteria	1MXIA@1224,1RPXK@1236,3XPGU@561,COG0834@1,COG0834@2	NA|NA|NA	ET	belongs to the bacterial solute-binding protein 3 family
C1_02370	481805.EcolC_2737	6.9e-217	759.6	Escherichia	rumB	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.189,2.1.1.190	ko:K03212,ko:K03215					ko00000,ko01000,ko03009				Bacteria	1N8DN@1224,1RMX4@1236,3XP7M@561,COG2265@1,COG2265@2	NA|NA|NA	J	Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA
C1_02371	155864.EDL933_0987	2.4e-81	308.1	Escherichia	ybjO	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1RGQB@1224,1S32T@1236,2E0RG@1,32W9M@2,3XPB5@561	NA|NA|NA	S	Protein of unknown function (DUF2593)
C1_02372	1440052.EAKF1_ch0616c	1.3e-146	525.8	Escherichia	potI	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0016020,GO:0016021,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351		ko:K11070,ko:K11074	ko02010,map02010	M00299,M00300			ko00000,ko00001,ko00002,ko02000	3.A.1.11.1,3.A.1.11.2		iG2583_1286.G2583_1088,iSBO_1134.SBO_1939,ic_1306.c0990	Bacteria	1MVC5@1224,1RQB7@1236,3XPAQ@561,COG1177@1,COG1177@2	NA|NA|NA	P	Required for the activity of the bacterial periplasmic transport system of putrescine
C1_02373	198214.SF0810	2.2e-176	624.8	Gammaproteobacteria	potH	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351		ko:K11075	ko02010,map02010	M00300			ko00000,ko00001,ko00002,ko02000	3.A.1.11.2		iAF1260.b0856,iBWG_1329.BWG_0709,iE2348C_1286.E2348C_0853,iECDH10B_1368.ECDH10B_0926,iECDH1ME8569_1439.ECDH1ME8569_0808,iEcDH1_1363.EcDH1_2786,iJO1366.b0856,iJR904.b0856,iY75_1357.Y75_RS04455	Bacteria	1MVGM@1224,1RNNZ@1236,COG1176@1,COG1176@2	NA|NA|NA	P	ABC-type spermidine putrescine transport system, permease component I
C1_02374	316407.85674780	1.2e-213	748.8	Escherichia	potG	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0016020,GO:0016021,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351		ko:K11076	ko02010,map02010	M00300			ko00000,ko00001,ko00002,ko02000	3.A.1.11.2		iSDY_1059.SDY_0740,iYL1228.KPN_00886	Bacteria	1MU3I@1224,1RNPX@1236,3XNR2@561,COG3842@1,COG3842@2	NA|NA|NA	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
C1_02375	316407.1651387	3.5e-213	747.3	Escherichia	potF	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0019808,GO:0019810,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0051179,GO:0051234,GO:0070405,GO:0071702,GO:0071705		ko:K11073	ko02010,map02010	M00300			ko00000,ko00001,ko00002,ko02000	3.A.1.11.2		iB21_1397.B21_00865,iECBD_1354.ECBD_2740,iECB_1328.ECB_00859,iECD_1391.ECD_00859,iEcHS_1320.EcHS_A0957,iEcolC_1368.EcolC_2742,iPC815.YPO1331	Bacteria	1MUYW@1224,1RM7W@1236,3XN5N@561,COG0687@1,COG0687@2	NA|NA|NA	P	Required for the activity of the bacterial periplasmic transport system of putrescine
C1_02376	155864.EDL933_0980	2.5e-83	314.7	Escherichia	ybjN	GO:0001558,GO:0008150,GO:0009297,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0010639,GO:0016043,GO:0022607,GO:0030030,GO:0030031,GO:0030308,GO:0031344,GO:0031345,GO:0032879,GO:0033043,GO:0040008,GO:0040012,GO:0040013,GO:0043711,GO:0043900,GO:0043901,GO:0044085,GO:0044087,GO:0045926,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051129,GO:0051270,GO:0051271,GO:0060491,GO:0065007,GO:0071840,GO:1900190,GO:1900191,GO:1900231,GO:1900232,GO:1902021,GO:1902115,GO:1902116,GO:1902201,GO:1902208,GO:1902209,GO:2000145,GO:2000146											Bacteria	1RAPN@1224,1S261@1236,2DC0R@1,2ZC96@2,3XNUI@561	NA|NA|NA	S	negative regulation of organelle assembly
C1_02377	155864.EDL933_0979	3.7e-165	587.4	Escherichia	rimK	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016874,GO:0016879,GO:0016881,GO:0018169,GO:0018410,GO:0019538,GO:0031668,GO:0033554,GO:0036211,GO:0042802,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0070739,GO:0071496,GO:0071704,GO:0140096,GO:1901564	6.3.1.17,6.3.2.32,6.3.2.41	ko:K05844,ko:K14940,ko:K18310	ko00250,ko00680,ko01100,ko01120,map00250,map00680,map01100,map01120		R09401,R10677,R10678	RC00064,RC00090,RC00141,RC03233	ko00000,ko00001,ko01000,ko03009				Bacteria	1MX62@1224,1RM8B@1236,3XMV6@561,COG0189@1,COG0189@2	NA|NA|NA	F	Is an L-glutamate ligase that catalyzes the ATP- dependent post-translational addition of glutamate residues to the C-terminus of ribosomal protein S6 (RpsF). Is also able to catalyze the synthesis of poly-alpha-glutamate in vitro, via ATP hydrolysis from unprotected glutamate as substrate. The number of glutamate residues added to either RpsF or to poly-alpha-glutamate changes with pH
C1_02378	316407.1651385	8.5e-136	489.6	Escherichia	nfsA	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0010181,GO:0016491,GO:0016651,GO:0016657,GO:0032553,GO:0034567,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0097159,GO:0097367,GO:1901265,GO:1901363	1.5.1.38,1.5.1.39	ko:K10678,ko:K19285,ko:K19286	ko00633,ko00740,ko01100,ko01120,map00633,map00740,map01100,map01120		R05705,R05706,R08014,R08017,R08042	RC00126,RC00250	ko00000,ko00001,ko01000				Bacteria	1NIJ8@1224,1RMRT@1236,3XNFS@561,COG0778@1,COG0778@2	NA|NA|NA	C	Catalyzes the reduction of nitroaromatic compounds using NADPH. Has a broad electron acceptor specificity. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product. Major oxygen-insensitive nitroreductase in E.coli
C1_02379	316407.4062439	2.6e-40	171.0	Escherichia	ybjC	GO:0001101,GO:0005575,GO:0006950,GO:0008150,GO:0009635,GO:0009636,GO:0010033,GO:0016020,GO:0042221,GO:0050896,GO:0097305,GO:1901422,GO:1901562,GO:1901700											Bacteria	1NB1Y@1224,1S9M0@1236,2E45I@1,32Z1J@2,3XPXH@561	NA|NA|NA	S	response to herbicide
C1_02380	198214.SF0802	4.3e-42	176.8	Gammaproteobacteria	grxA		1.17.4.1	ko:K00526,ko:K03674,ko:K03676	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03110,ko03400			iAF1260.b0849,iB21_1397.B21_00860,iBWG_1329.BWG_0702,iEC55989_1330.EC55989_0894,iECBD_1354.ECBD_2745,iECB_1328.ECB_00854,iECDH10B_1368.ECDH10B_0919,iECDH1ME8569_1439.ECDH1ME8569_0801,iECD_1391.ECD_00854,iECO111_1330.ECO111_0918,iECO26_1355.ECO26_0976,iECSE_1348.ECSE_0907,iECW_1372.ECW_m0957,iEKO11_1354.EKO11_2987,iETEC_1333.ETEC_0916,iEcDH1_1363.EcDH1_2793,iEcE24377_1341.EcE24377A_0921,iJO1366.b0849,iSBO_1134.SBO_0783,iSFV_1184.SFV_0834,iSF_1195.SF0802,iSFxv_1172.SFxv_0871,iSSON_1240.SSON_0834,iS_1188.S0845,iSbBS512_1146.SbBS512_E2483,iWFL_1372.ECW_m0957,iY75_1357.Y75_RS04415	Bacteria	1RGZ7@1224,1S5ZP@1236,COG0695@1,COG0695@2	NA|NA|NA	O	Glutaredoxin
C1_02381	155864.EDL933_0975	7.4e-67	259.6	Escherichia	ybjM	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1RJKC@1224,1S7JU@1236,2AKS6@1,31BJ4@2,3XQ11@561	NA|NA|NA	S	Putative inner membrane protein of Enterobacteriaceae
C1_02382	155864.EDL933_0974	4.7e-310	1069.7	Escherichia	ybjL	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03281,ko:K07085					ko00000	2.A.49,2.A.81			Bacteria	1MUVM@1224,1RQ47@1236,3XMX3@561,COG0569@1,COG0569@2,COG2985@1,COG2985@2	NA|NA|NA	P	potassium ion transport
C1_02383	155864.EDL933_0973	2.3e-93	348.2	Escherichia	ybjK	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:1990837,GO:2000112,GO:2001141											Bacteria	1R94Q@1224,1S24A@1236,3XMEA@561,COG3226@1,COG3226@2	NA|NA|NA	K	Regulates the expression of a number of genes involved in biofilm formation and stress response. Target genes include six stress-response transcriptional regulators csgD, which is a master regulator of biofilm formation, appY, sxy, ycgF, fimB and rcdA itself. This indicates that a large number of genes must be regulated indirectly via these transcriptional regulators. Acts by binding to the upstream region of its target genes
C1_02384	316407.4062429	2.4e-201	708.0	Escherichia	ybjJ	GO:0003674,GO:0005215,GO:0005351,GO:0005354,GO:0005402,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0008643,GO:0008645,GO:0009679,GO:0010035,GO:0015075,GO:0015077,GO:0015078,GO:0015144,GO:0015145,GO:0015146,GO:0015149,GO:0015150,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015517,GO:0015518,GO:0015535,GO:0015672,GO:0015749,GO:0015750,GO:0015751,GO:0015756,GO:0015757,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034219,GO:0034220,GO:0042221,GO:0042900,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0072714,GO:0098655,GO:0098660,GO:0098662,GO:1902600		ko:K02429,ko:K06141					ko00000,ko02000	2.A.1,2.A.1.7			Bacteria	1MVR9@1224,1RNEI@1236,3XNSE@561,COG0738@1,COG0738@2	NA|NA|NA	G	transmembrane transport
C1_02385	481805.EcolC_2798	2.3e-150	538.1	Escherichia	ybjI	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042578,GO:0042726,GO:0042727,GO:0043167,GO:0043169,GO:0043726,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.1.3.102,3.1.3.104,3.1.3.23	ko:K07757,ko:K20861	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00548,R00804,R07280	RC00017	ko00000,ko00001,ko00002,ko01000				Bacteria	1Q5HK@1224,1RQ8H@1236,3XN2K@561,COG0561@1,COG0561@2	NA|NA|NA	S	Catalyzes the dephosphorylation of 5-amino-6-(5-phospho- D-ribitylamino)uracil, and thus could be involved in the riboflavin biosynthesis pathway. Is also able to dephosphorylate flavin mononucleotide (FMN), erythrose 4-phosphate and other phosphoric acid esters
C1_02386	198214.SF0796	8.5e-36	156.0	Gammaproteobacteria	ybjH												Bacteria	1N6A5@1224,1SBQ1@1236,2DZVA@1,32VJW@2	NA|NA|NA		
C1_02387	155864.EDL933_0969	1.2e-222	778.9	Escherichia	cmr	GO:0003674,GO:0005215,GO:0005451,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006814,GO:0006855,GO:0006873,GO:0006885,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015079,GO:0015081,GO:0015238,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015386,GO:0015491,GO:0015672,GO:0015893,GO:0016020,GO:0016021,GO:0019725,GO:0022804,GO:0022821,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030004,GO:0030641,GO:0031224,GO:0031226,GO:0034220,GO:0035725,GO:0042221,GO:0042493,GO:0042592,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0046873,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051234,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099516,GO:1902600		ko:K08160					ko00000,ko01504,ko02000	2.A.1.2.19		iSFV_1184.SFV_0827	Bacteria	1MUWH@1224,1RRF6@1236,3XPGY@561,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
C1_02388	199310.c0926	8.6e-110	402.9	Escherichia	ybjG	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0042221,GO:0044464,GO:0046677,GO:0050380,GO:0050896,GO:0071944	3.6.1.27	ko:K19302	ko00550,map00550		R05627	RC00002	ko00000,ko00001,ko01000,ko01011			iEC042_1314.EC042_0932	Bacteria	1R56P@1224,1RRTS@1236,3XPFA@561,COG0671@1,COG0671@2	NA|NA|NA	I	Overexpression leads to increased undecaprenyl diphosphatase activity and to increased resistance to bacitracin. May have a preferred substrate other than undecaprenyl diphosphate in vivo
C1_02389	198214.SF0793	1.4e-144	518.8	Gammaproteobacteria	deoR	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141		ko:K11534					ko00000,ko03000				Bacteria	1MY40@1224,1RR32@1236,COG1349@1,COG1349@2	NA|NA|NA	K	transcriptional
C1_02390	155864.EDL933_0966	3.9e-226	790.4	Escherichia	dacC	GO:0000270,GO:0003674,GO:0003824,GO:0004175,GO:0004180,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008360,GO:0008658,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100				ko00000,ko00001,ko01000,ko01002,ko01011			iEC55989_1330.EC55989_2269,iSFV_1184.SFV_0694,iSbBS512_1146.SbBS512_E2506	Bacteria	1MUU7@1224,1RMJA@1236,3XMW7@561,COG1686@1,COG1686@2	NA|NA|NA	M	Belongs to the peptidase S11 family
C1_02391	155864.EDL933_0965	6.9e-118	429.9	Escherichia	yliJ	GO:0003674,GO:0003824,GO:0004364,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016740,GO:0016765,GO:0030611,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0055114	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418		R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2			Bacteria	1RA4M@1224,1S2K3@1236,3XNCW@561,COG0625@1,COG0625@2	NA|NA|NA	O	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles
C1_02392	316407.4062422	6.6e-220	769.6	Escherichia	yliI	GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016901,GO:0019842,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044464,GO:0046872,GO:0048037,GO:0048038,GO:0055114,GO:0070968,GO:0097159,GO:1901363		ko:K21430					ko00000,ko01000			iSbBS512_1146.SbBS512_E2507	Bacteria	1MV2E@1224,1RNGN@1236,3XMGG@561,COG2133@1,COG2133@2	NA|NA|NA	G	Can oxidize glucose to gluconolactone. Can also utilize D-arabinose, L- arabinose and 2-deoxy-glucose. Has higher activity towards oligomeric sugars, such as maltose, maltotriose or cellobiose. It may function to input sugar-derived electrons into the respiratory network
C1_02393	155864.EDL933_0963	1e-63	249.2	Escherichia	bssR	GO:0008150,GO:0010468,GO:0019222,GO:0043900,GO:0050789,GO:0050794,GO:0060255,GO:0065007,GO:1900190		ko:K19688					ko00000,ko02048				Bacteria	1RE5M@1224,1S45I@1236,29WPV@1,30IAT@2,3XPW2@561	NA|NA|NA	S	Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway
C1_02394	155864.EDL933_0962	2.5e-258	897.5	Escherichia	rimO	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016782,GO:0018193,GO:0018197,GO:0018198,GO:0018339,GO:0019538,GO:0035596,GO:0035599,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901564	2.8.4.4	ko:K14441			R10652	RC00003,RC03217	ko00000,ko01000,ko03009				Bacteria	1MU7N@1224,1RN46@1236,3XM3X@561,COG0621@1,COG0621@2	NA|NA|NA	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12
C1_02395	316407.4062411	3.9e-243	847.0	Escherichia	yliF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944										iSBO_1134.SBO_0726	Bacteria	1R80Z@1224,1RZUV@1236,3XNK5@561,COG2199@1,COG2199@2	NA|NA|NA	T	diguanylate cyclase activity
C1_02396	316407.4062410	0.0	1534.2	Escherichia	yliE	GO:0003674,GO:0003824,GO:0008081,GO:0016787,GO:0016788,GO:0042578,GO:0071111	3.1.4.52	ko:K20964	ko05111,map05111				ko00000,ko00001,ko01000				Bacteria	1N299@1224,1T2T4@1236,3XNPI@561,COG2200@1,COG2200@2	NA|NA|NA	T	Overexpression reduces biofilm formation. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria
C1_02397	155864.EDL933_0957	3.7e-160	570.9	Escherichia	gsiD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K02034,ko:K12370,ko:K13891,ko:K15582,ko:K15586	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00324,M00348,M00439,M00440			ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.11,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25		iAF1260.b1245,iAF1260.b3542,iAPECO1_1312.APECO1_2906,iB21_1397.B21_01229,iB21_1397.B21_03344,iBWG_1329.BWG_3231,iE2348C_1286.E2348C_3790,iEC042_1314.EC042_3848,iEC55989_1330.EC55989_1342,iEC55989_1330.EC55989_3993,iECABU_c1320.ECABU_c08730,iECABU_c1320.ECABU_c39840,iECBD_1354.ECBD_0194,iECBD_1354.ECBD_2377,iECB_1328.ECB_01219,iECB_1328.ECB_03393,iECDH10B_1368.ECDH10B_1307,iECDH10B_1368.ECDH10B_3721,iECDH1ME8569_1439.ECDH1ME8569_1185,iECDH1ME8569_1439.ECDH1ME8569_3422,iECD_1391.ECD_01219,iECD_1391.ECD_03393,iECED1_1282.ECED1_4221,iECH74115_1262.ECH74115_4910,iECIAI1_1343.ECIAI1_1264,iECIAI1_1343.ECIAI1_3700,iECIAI39_1322.ECIAI39_4051,iECNA114_1301.ECNA114_3693,iECO103_1326.ECO103_1345,iECO103_1326.ECO103_4274,iECO111_1330.ECO111_1572,iECO111_1330.ECO111_4358,iECO26_1355.ECO26_1756,iECO26_1355.ECO26_4636,iECOK1_1307.ECOK1_3988,iECP_1309.ECP_0846,iECP_1309.ECP_3643,iECS88_1305.ECS88_3962,iECSE_1348.ECSE_1293,iECSE_1348.ECSE_3815,iECSF_1327.ECSF_3376,iECSP_1301.ECSP_1637,iECSP_1301.ECSP_4533,iECUMN_1333.ECUMN_1542,iECUMN_1333.ECUMN_4052,iECW_1372.ECW_m1337,iECW_1372.ECW_m3808,iECs_1301.ECs1745,iECs_1301.ECs4422,iEKO11_1354.EKO11_0191,iEKO11_1354.EKO11_2607,iETEC_1333.ETEC_1347,iETEC_1333.ETEC_3787,iEcDH1_1363.EcDH1_0170,iEcDH1_1363.EcDH1_2403,iEcE24377_1341.EcE24377A_1393,iEcE24377_1341.EcE24377A_4034,iEcHS_1320.EcHS_A1354,iEcHS_1320.EcHS_A3741,iEcSMS35_1347.EcSMS35_3861,iEcolC_1368.EcolC_0173,iEcolC_1368.EcolC_2383,iG2583_1286.G2583_1517,iG2583_1286.G2583_4279,iJO1366.b1245,iJO1366.b3542,iLF82_1304.LF82_0517,iNRG857_1313.NRG857_17605,iSSON_1240.SSON_1935,iSbBS512_1146.SbBS512_E3843,iUMN146_1321.UM146_17880,iUMNK88_1353.UMNK88_1565,iUMNK88_1353.UMNK88_4323,iUTI89_1310.UTI89_C4080,iWFL_1372.ECW_m1337,iWFL_1372.ECW_m3808,iY75_1357.Y75_RS06515,iY75_1357.Y75_RS19465,iZ_1308.Z2021,iZ_1308.Z4959,ic_1306.c0917,ic_1306.c4357	Bacteria	1MWMX@1224,1RNBC@1236,3XMH1@561,COG1173@1,COG1173@2	NA|NA|NA	EP	Part of the ABC transporter complex GsiABCD involved in glutathione import. Probably responsible for the translocation of the substrate across the membrane
C1_02398	316407.4062408	1.4e-164	585.5	Escherichia	gsiC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K13890	ko02010,map02010	M00348			ko00000,ko00001,ko00002,ko02000	3.A.1.5.11		ic_1306.c0916	Bacteria	1MU8Z@1224,1RNJ1@1236,3XMKP@561,COG0601@1,COG0601@2	NA|NA|NA	EP	Part of the ABC transporter complex GsiABCD involved in glutathione import. Probably responsible for the translocation of the substrate across the membrane
C1_02399	198214.SF0780	4.3e-294	1016.5	Gammaproteobacteria	gsiB	GO:0005575,GO:0005623,GO:0006810,GO:0006857,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0015833,GO:0030288,GO:0030313,GO:0031975,GO:0033554,GO:0042597,GO:0042886,GO:0042938,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0071702,GO:0071705		ko:K13889	ko02010,map02010	M00348			ko00000,ko00001,ko00002,ko02000	3.A.1.5.11		iNRG857_1313.NRG857_03725	Bacteria	1MUZH@1224,1RNFB@1236,COG0747@1,COG0747@2	NA|NA|NA	E	Extracellular solute-binding protein, family 5
C1_02400	511145.b0829	0.0	1194.5	Escherichia	gsiA	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008144,GO:0016020,GO:0016021,GO:0017076,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K02031,ko:K02032,ko:K13892	ko02010,ko02024,map02010,map02024	M00239,M00348			ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.11		iSbBS512_1146.SbBS512_E2519	Bacteria	1MU09@1224,1RMEI@1236,3XNVV@561,COG1123@1,COG4172@2	NA|NA|NA	P	Part of the ABC transporter complex GsiABCD involved in glutathione import. Responsible for energy coupling to the transport system
C1_02401	469008.B21_00812	1e-176	625.9	Escherichia	iaaA	GO:0003674,GO:0003824,GO:0004067,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008798,GO:0010467,GO:0016485,GO:0016540,GO:0016787,GO:0016810,GO:0016811,GO:0019538,GO:0043170,GO:0044238,GO:0051604,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.19.5,3.5.1.1	ko:K01424,ko:K13051	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110		R00485	RC00010,RC02798	ko00000,ko00001,ko01000,ko01002			iZ_1308.Z1051m	Bacteria	1MWFC@1224,1RNUR@1236,3XPAN@561,COG1446@1,COG1446@2	NA|NA|NA	E	Degrades proteins damaged by L-isoaspartyl residue formation (also known as beta-Asp residues). Degrades L- isoaspartyl-containing di- and maybe also tripeptides. Also has L- asparaginase activity, although this may not be its principal function
C1_02402	199310.c0912	2.8e-232	810.8	Escherichia	moeA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0018315,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0032324,GO:0034641,GO:0036211,GO:0042040,GO:0042278,GO:0042802,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061598,GO:0061599,GO:0070566,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100		R09735	RC03462	ko00000,ko00001,ko01000			iEcHS_1320.EcHS_A0885	Bacteria	1MVD5@1224,1RMQU@1236,3XN1A@561,COG0303@1,COG0303@2	NA|NA|NA	H	Molybdopterin
C1_02403	469008.B21_00810	5.5e-138	496.9	Escherichia	moeB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0061605,GO:0070566,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.73,2.7.7.80	ko:K03148,ko:K21029	ko00730,ko01100,ko04122,map00730,map01100,map04122		R07459	RC00043	ko00000,ko00001,ko01000			iECIAI1_1343.ECIAI1_0865,iECIAI39_1322.ECIAI39_4382,iECW_1372.ECW_m0884,iEKO11_1354.EKO11_3059,iETEC_1333.ETEC_0893,iEcE24377_1341.EcE24377A_0897,iEcSMS35_1347.EcSMS35_0851,iWFL_1372.ECW_m0884	Bacteria	1MW7H@1224,1RPJ3@1236,3XMVK@561,COG0476@1,COG0476@2	NA|NA|NA	H	molybdopterin-synthase adenylyltransferase activity
C1_02404	155864.EDL933_0949	3.2e-113	414.5	Escherichia	tal	GO:0003674,GO:0003824,GO:0004801,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016832,GO:0044424,GO:0044464,GO:0097023	2.2.1.2	ko:K00616,ko:K08313,ko:K08314	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000			iEC042_1314.EC042_0914,iECH74115_1262.ECH74115_5407,iECSP_1301.ECSP_5016,iECs_1301.ECs4875,iG2583_1286.G2583_4758,iSBO_1134.SBO_0715,iSF_1195.SF0775,iSFxv_1172.SFxv_0845,iS_1188.S0818,iZ_1308.Z5501	Bacteria	1MWQ8@1224,1RNWN@1236,3XP1P@561,COG0176@1,COG0176@2	NA|NA|NA	G	Catalyzes the reversible formation of fructose 6- phosphate from dihydroxyacetone and D-glyceraldehyde 3-phosphate via an aldolization reaction
C1_02405	316407.4062398	3.4e-174	617.5	Escherichia	ybiY		1.97.1.4	ko:K04069			R04710		ko00000,ko01000				Bacteria	1QJHU@1224,1RQUF@1236,3XP0Z@561,COG1180@1,COG1180@2	NA|NA|NA	O	Activation of pyruvate formate-lyase 2 under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C1_02406	199310.c0908	0.0	1633.2	Escherichia	ybiW	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120		R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000				Bacteria	1MWBF@1224,1RMEK@1236,3XN60@561,COG1882@1,COG1882@2	NA|NA|NA	C	formate C-acetyltransferase activity
C1_02407	155864.EDL933_0945	8.1e-151	539.7	Escherichia	supH	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0050308	3.1.3.102,3.1.3.104,3.1.3.23	ko:K07757,ko:K20861	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00548,R00804,R07280	RC00017	ko00000,ko00001,ko00002,ko01000			iECO103_1326.ECO103_0866,iLF82_1304.LF82_2649,iNRG857_1313.NRG857_03685	Bacteria	1Q5HK@1224,1RQ8H@1236,3XNYT@561,COG0561@1,COG0561@2	NA|NA|NA	S	Catalyzes the hydrolysis of sugar phosphate to sugar and inorganic phosphate. Has a wide substrate specificity catalyzing the hydrolysis of ribose-5-phosphate, glucose-6-phosphate, fructose-1-phosphate, acetyl-phosphate, glycerol-1-phosphate, glycerol-2-phosphate, 2-deoxy-glucose-6-phosphate, mannose-6- phosphate and fructose-6-phosphate. Appears to have a low level of phosphotransferase activity using monophosphates as the phosphate donor
C1_02408	316407.4062388	2.7e-254	884.0	Escherichia	ybiU												Bacteria	1QT0R@1224,1RP98@1236,2CK8J@1,2Z7SR@2,3XPAS@561	NA|NA|NA	S	Protein of unknown function (DUF1479)
C1_02409	637910.ROD_00481	2.1e-161	575.1	Gammaproteobacteria	piv			ko:K07486					ko00000				Bacteria	1MXKJ@1224,1RSCP@1236,COG3547@1,COG3547@2	NA|NA|NA	L	Transposase
C1_02410	316407.4062355	5.4e-232	810.1	Escherichia	rhlE	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0006996,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0042254,GO:0042255,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0065003,GO:0070035,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0140098,GO:1901360	3.6.4.13	ko:K11927	ko03018,map03018				ko00000,ko00001,ko01000,ko03019				Bacteria	1MU49@1224,1RMWA@1236,3XPAR@561,COG0513@1,COG0513@2	NA|NA|NA	F	DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA
C1_02411	155864.EDL933_0917	2.9e-122	444.5	Escherichia	ybiH	GO:0003674,GO:0003700,GO:0005488,GO:0005515,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031333,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043254,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051130,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2000144,GO:2001141											Bacteria	1NDME@1224,1RQQB@1236,3XNKM@561,COG1309@1,COG1309@2	NA|NA|NA	K	Transcriptional regulator
C1_02412	155864.EDL933_0916	4e-152	544.3	Escherichia	ybhG	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0042221,GO:0044464,GO:0046677,GO:0050896,GO:0071944		ko:K01993					ko00000				Bacteria	1MUG6@1224,1RP16@1236,3XNN2@561,COG0845@1,COG0845@2	NA|NA|NA	M	UPF0194 membrane protein YbhG
C1_02413	198214.SF0744	0.0	1158.3	Gammaproteobacteria	ybhF	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015562,GO:0015893,GO:0016020,GO:0022857,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944		ko:K01990,ko:K13926		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	1MUX3@1224,1RMM4@1236,COG1131@1,COG1131@2	NA|NA|NA	V	(ABC) transporter
C1_02414	155864.EDL933_0914	2.4e-201	708.0	Escherichia	ybhS	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0008150,GO:0015562,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944		ko:K01992		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	1MW5R@1224,1RPB4@1236,3XPH4@561,COG0842@1,COG0842@2	NA|NA|NA	V	transmembrane transport
C1_02415	1440052.EAKF1_ch0678	7.5e-200	703.0	Escherichia	ybhR	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0015562,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0033554,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071944		ko:K01992		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	1MW5R@1224,1SYDD@1236,3XP79@561,COG0842@1,COG0842@2	NA|NA|NA	V	efflux transmembrane transporter activity
C1_02416	155864.EDL933_0912	4.7e-67	260.4	Escherichia	ybhQ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1REJF@1224,1S4G4@1236,2CICU@1,2ZPQP@2,3XPKZ@561	NA|NA|NA	S	Putative inner membrane protein YbhQ
C1_02417	155864.EDL933_0911	9.2e-149	532.7	Escherichia	ybhP												Bacteria	1MVN7@1224,1RNSP@1236,3XNI0@561,COG3568@1,COG3568@2	NA|NA|NA	L	Endonuclease/Exonuclease/phosphatase family
C1_02418	155864.EDL933_0910	8e-243	845.9	Escherichia	clsB	GO:0003674,GO:0003824,GO:0004620,GO:0004630,GO:0005575,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008081,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008808,GO:0009058,GO:0009987,GO:0016020,GO:0016298,GO:0016740,GO:0016772,GO:0016780,GO:0016787,GO:0016788,GO:0019637,GO:0030572,GO:0032048,GO:0032049,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576	2.7.8.8	ko:K00998,ko:K06131,ko:K06132	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800,R07390,R11062	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000			iECED1_1282.ECED1_0754,iECH74115_1262.ECH74115_3822,iECSP_1301.ECSP_3532,iSDY_1059.SDY_1307	Bacteria	1MWUW@1224,1RNEC@1236,3XMFM@561,COG1502@1,COG1502@2	NA|NA|NA	I	Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1_02419	316407.4062345	1.1e-170	605.9	Escherichia	mprF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.3.2.3	ko:K07027,ko:K14205	ko01503,ko02020,ko05150,map01503,map02020,map05150	M00726			ko00000,ko00001,ko00002,ko01000,ko01504,ko02000	2.A.1.3.37,4.D.2		iYO844.BG12900	Bacteria	1MXH9@1224,1RS5E@1236,3XP2Z@561,COG0392@1,COG0392@2	NA|NA|NA	S	Lysylphosphatidylglycerol synthase TM region
C1_02420	198214.SF0737	1.4e-119	435.6	Gammaproteobacteria	ybhM	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K06890,ko:K19416		M00742			ko00000,ko00002,ko02000	1.A.14.2.1			Bacteria	1NN7Z@1224,1SIS9@1236,COG0670@1,COG0670@2	NA|NA|NA	S	Belongs to the BI1 family
C1_02421	199310.c0868	1.9e-116	425.2	Escherichia	ybhL	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K06890,ko:K19416		M00742			ko00000,ko00002,ko02000	1.A.14.2.1			Bacteria	1MU69@1224,1RN8Q@1236,3XNCH@561,COG0670@1,COG0670@2	NA|NA|NA	S	Inhibitor of apoptosis-promoting Bax1
C1_02422	199310.c0867	2.9e-81	307.8	Escherichia	moaE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122		R09395	RC02507	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_1305,iEC042_1314.EC042_0869,iEC55989_1330.EC55989_0828,iECABU_c1320.ECABU_c08270,iECED1_1282.ECED1_0750,iECIAI1_1343.ECIAI1_0820,iECIAI39_1322.ECIAI39_0761,iECNA114_1301.ECNA114_0717,iECO103_1326.ECO103_0820,iECO111_1330.ECO111_0846,iECO26_1355.ECO26_0911,iECOK1_1307.ECOK1_0787,iECP_1309.ECP_0799,iECS88_1305.ECS88_0802,iECSE_1348.ECSE_0839,iECSF_1327.ECSF_0711,iECW_1372.ECW_m0841,iEKO11_1354.EKO11_3101,iEcE24377_1341.EcE24377A_0848,iG2583_1286.G2583_1013,iLF82_1304.LF82_1369,iNRG857_1313.NRG857_03500,iSSON_1240.SSON_0764,iUMN146_1321.UM146_13720,iUTI89_1310.UTI89_C0785,iWFL_1372.ECW_m0841,ic_1306.c0867	Bacteria	1RGUX@1224,1S5YH@1236,3XPIK@561,COG0314@1,COG0314@2	NA|NA|NA	H	Converts molybdopterin precursor Z to molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by MoaD
C1_02423	155864.EDL933_0905	1.5e-36	158.3	Escherichia	moaD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.77,2.8.1.12	ko:K03636,ko:K03752,ko:K21142	ko00790,ko01100,ko04122,map00790,map01100,map04122		R09395,R11581	RC02507	ko00000,ko00001,ko01000			iE2348C_1286.E2348C_0736,iEC55989_1330.EC55989_0827,iG2583_1286.G2583_1012,iLF82_1304.LF82_1368,iNRG857_1313.NRG857_03495,iSFV_1184.SFV_0767,iSF_1195.SF0734,iSFxv_1172.SFxv_0800,iSSON_1240.SSON_0763,iS_1188.S0775	Bacteria	1N0IE@1224,1S8S1@1236,3XQ05@561,COG1977@1,COG1977@2	NA|NA|NA	H	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C1_02424	155864.EDL933_0904	1.9e-83	315.1	Escherichia	moaC	GO:0002682,GO:0002683,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009605,GO:0009607,GO:0009987,GO:0016043,GO:0016829,GO:0016849,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0022607,GO:0031347,GO:0031348,GO:0034214,GO:0035821,GO:0040007,GO:0042802,GO:0043170,GO:0043207,GO:0043545,GO:0043933,GO:0044003,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044413,GO:0044414,GO:0044419,GO:0045088,GO:0045824,GO:0046483,GO:0048519,GO:0048583,GO:0048585,GO:0050776,GO:0050777,GO:0050789,GO:0050896,GO:0051186,GO:0051188,GO:0051189,GO:0051259,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0051832,GO:0051833,GO:0052031,GO:0052037,GO:0052167,GO:0052170,GO:0052173,GO:0052200,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0061799,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0075136,GO:0080134,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122		R11372	RC03425	ko00000,ko00001,ko01000				Bacteria	1RCYZ@1224,1S3ST@1236,3XNPB@561,COG0315@1,COG0315@2	NA|NA|NA	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)
C1_02425	155864.EDL933_0903	4.5e-91	340.5	Escherichia	moaB	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0042802,GO:0044424,GO:0044444,GO:0044464	2.7.7.75	ko:K03638,ko:K03831	ko00790,ko01100,ko04122,map00790,map01100,map04122		R09726	RC00002	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_1969,iECABU_c1320.ECABU_c00100,iECED1_1282.ECED1_0009,iECNA114_1301.ECNA114_4653,iECP_1309.ECP_0010,iECS88_1305.ECS88_0010,iECSF_1327.ECSF_0009,iECUMN_1333.ECUMN_0010,iEcSMS35_1347.EcSMS35_0008,iLF82_1304.LF82_1379,iNRG857_1313.NRG857_00050,iUMN146_1321.UM146_22820	Bacteria	1R9W2@1224,1S21E@1236,3XP2R@561,COG0521@1,COG0521@2	NA|NA|NA	H	May be involved in the biosynthesis of molybdopterin
C1_02426	155864.EDL933_0902	1.3e-190	672.2	Escherichia	moaA	GO:0003674,GO:0003824,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016829,GO:0016830,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051189,GO:0061798,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122		R09394	RC03420	ko00000,ko00001,ko01000			iSbBS512_1146.SbBS512_E2571,ic_1306.c0862	Bacteria	1MW3W@1224,1RR68@1236,3XM5E@561,COG2896@1,COG2896@2	NA|NA|NA	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C1_02427	316407.4062340	1e-162	579.3	Escherichia	ybhK												Bacteria	1NW3K@1224,1RQP9@1236,3XPC9@561,COG0391@1,COG0391@2	NA|NA|NA	S	Required for morphogenesis under gluconeogenic growth conditions
C1_02428	155864.EDL933_0900	0.0	1297.0	Escherichia	uvrB	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009314,GO:0009380,GO:0009628,GO:0032991,GO:0042802,GO:0044424,GO:0044464,GO:0050896,GO:1902494,GO:1905347,GO:1905348,GO:1990391		ko:K03702,ko:K08999	ko03420,map03420				ko00000,ko00001,ko03400				Bacteria	1MUFK@1224,1RN6Z@1236,3XMDY@561,COG0556@1,COG0556@2	NA|NA|NA	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
C1_02429	198214.SF0728	3.1e-124	451.1	Gammaproteobacteria	bioD	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004141,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017076,GO:0017144,GO:0018130,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.3.3	ko:K01935	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03182	RC00868	ko00000,ko00001,ko00002,ko01000			iEC55989_1330.EC55989_0821,iECIAI1_1343.ECIAI1_0813,iECO103_1326.ECO103_0813,iECO111_1330.ECO111_0839,iECO26_1355.ECO26_0904,iECSE_1348.ECSE_0831,iECW_1372.ECW_m0833,iEKO11_1354.EKO11_3108,iEcE24377_1341.EcE24377A_0841,iSFV_1184.SFV_0761,iSSON_1240.SSON_0757,iWFL_1372.ECW_m0833,ic_1306.c0858	Bacteria	1RDRK@1224,1RSHS@1236,COG0132@1,COG0132@2	NA|NA|NA	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C1_02430	316407.85674760	7e-141	506.5	Escherichia	bioC	GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008757,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0010340,GO:0016053,GO:0016740,GO:0016741,GO:0016787,GO:0016788,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032259,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0052689,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.197	ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000			iECP_1309.ECP_0791,iSBO_1134.SBO_0664,iSFV_1184.SFV_0760,iSF_1195.SF0727,iSFxv_1172.SFxv_0792,iSSON_1240.SSON_0756,iS_1188.S0768,iSbBS512_1146.SbBS512_E2575	Bacteria	1PA5F@1224,1RY7A@1236,3XP7T@561,COG0500@1,COG2226@2	NA|NA|NA	H	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway
C1_02431	316407.85674759	1.5e-206	725.3	Escherichia	bioF	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.3.1.47,2.8.1.6	ko:K00652,ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078,R03210,R10124	RC00004,RC00039,RC00441,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007			iEC55989_1330.EC55989_0819,iECO111_1330.ECO111_0837,iECO26_1355.ECO26_0902,iSDY_1059.SDY_0830	Bacteria	1MVVH@1224,1RNS6@1236,3XM4H@561,COG0156@1,COG0156@2	NA|NA|NA	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide
C1_02432	316407.85674758	2.5e-197	694.5	Escherichia	bioB	GO:0003674,GO:0003824,GO:0004076,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0017144,GO:0018130,GO:0019752,GO:0030312,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0070283,GO:0071704,GO:0071944,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000			iNJ661.Rv1589,iZ_1308.Z0994	Bacteria	1MVFF@1224,1RMEQ@1236,3XME5@561,COG0502@1,COG0502@2	NA|NA|NA	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C1_02433	198214.SF0725	1.7e-251	874.8	Gammaproteobacteria	bioA	GO:0003674,GO:0003824,GO:0004015,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007			iIT341.HP0976,iUTI89_1310.UTI89_C0772,iZ_1308.Z0993	Bacteria	1MU2N@1224,1RP0W@1236,COG0161@1,COG0161@2	NA|NA|NA	H	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor
C1_02434	316407.85674756	7.1e-91	339.7	Escherichia	ybhB	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0044424,GO:0044464,GO:0071944		ko:K06910					ko00000				Bacteria	1N0Y4@1224,1S400@1236,3XMZJ@561,COG1881@1,COG1881@2	NA|NA|NA	S	Phosphatidylethanolamine-binding protein
C1_02435	316407.85674755	2.3e-245	854.4	Escherichia	ybhC	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	3.1.1.11,4.2.2.2	ko:K01051,ko:K01728,ko:K10297	ko00040,ko01100,ko02024,map00040,map01100,map02024	M00081	R02361,R02362,R06240	RC00049,RC00460,RC00461,RC00705	ko00000,ko00001,ko00002,ko01000,ko04121				Bacteria	1MWT0@1224,1RRUY@1236,3XPDY@561,COG4677@1,COG4677@2	NA|NA|NA	M	Pectinesterase
C1_02436	316407.85674754	0.0	1515.0	Escherichia	ybhJ	GO:0006950,GO:0006979,GO:0008150,GO:0050896	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	1R4PE@1224,1S0EY@1236,3XNEB@561,COG1048@1,COG1048@2	NA|NA|NA	C	response to oxidative stress
C1_02437	316407.4062337	1.2e-261	908.7	Escherichia	ybhI	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0015291,GO:0015297,GO:0016020,GO:0022804,GO:0022857,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944		ko:K03319,ko:K09477,ko:K11106	ko02020,map02020				ko00000,ko00001,ko02000	2.A.47,2.A.47.3.2,2.A.47.3.3		iAF1260.b3063,iBWG_1329.BWG_2774,iECDH10B_1368.ECDH10B_3238,iECDH1ME8569_1439.ECDH1ME8569_2959,iECIAI1_1343.ECIAI1_3211,iETEC_1333.ETEC_3334,iEcDH1_1363.EcDH1_0637,iEcolC_1368.EcolC_0636,iJO1366.b3063,iJR904.b3063,iSF_1195.SF0891,iSSON_1240.SSON_0564,iS_1188.S0938,iUMNK88_1353.UMNK88_3815,iY75_1357.Y75_RS15915	Bacteria	1MUSA@1224,1RMF3@1236,3XP6G@561,COG0471@1,COG0471@2	NA|NA|NA	P	sodium ion transport
C1_02438	199310.c0846	3.3e-197	694.1	Escherichia	ybhH												Bacteria	1MXVV@1224,1RNE6@1236,3XM4F@561,COG2828@1,COG2828@2	NA|NA|NA	S	isomerase activity
C1_02439	155864.EDL933_0842	8.2e-179	632.9	Escherichia	ybhD	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:1901363,GO:1990837											Bacteria	1MUWX@1224,1RYWC@1236,3XMJF@561,COG0583@1,COG0583@2	NA|NA|NA	K	transcriptional regulator
C1_02440	316407.4062334	8.5e-195	686.0	Escherichia	pgl	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016787,GO:0016788,GO:0017057,GO:0044424,GO:0044444,GO:0044464,GO:0052689	3.1.1.31	ko:K07404	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000			iSSON_1240.SSON_0741	Bacteria	1MWGS@1224,1RNX2@1236,3XMN9@561,COG2706@1,COG2706@2	NA|NA|NA	F	Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate
C1_02441	362663.ECP_0778	4.9e-156	557.0	Escherichia	ybhA	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0033883,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0050308										iECSP_1301.ECSP_0819,iECs_1301.ECs0794,iG2583_1286.G2583_0932,iZ_1308.Z0936	Bacteria	1PGMI@1224,1RPYI@1236,3XPBW@561,COG0561@1,COG0561@2	NA|NA|NA	S	Pyridoxal phosphate phosphatase YbhA
C1_02442	155864.EDL933_0839	5.1e-198	696.8	Escherichia	modC	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008144,GO:0008150,GO:0008509,GO:0015075,GO:0015098,GO:0015103,GO:0015318,GO:0015399,GO:0015405,GO:0015412,GO:0015689,GO:0015698,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043225,GO:0043492,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0097159,GO:0097367,GO:0098656,GO:0099133,GO:1901265,GO:1901363	3.6.3.29	ko:K02017	ko02010,map02010	M00189			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8		iECNA114_1301.ECNA114_0696,iECSF_1327.ECSF_0691,iUMNK88_1353.UMNK88_805	Bacteria	1MU8K@1224,1RQCV@1236,3XNBJ@561,COG4148@1,COG4148@2	NA|NA|NA	P	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C1_02443	155864.EDL933_0838	4.8e-120	437.2	Escherichia	modB	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	3.6.3.29	ko:K02017,ko:K02018,ko:K15496	ko02010,map02010	M00189,M00423			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.5,3.A.1.8		iECO103_1326.ECO103_0752	Bacteria	1MUXR@1224,1RRDV@1236,3XMCK@561,COG4149@1,COG4149@2	NA|NA|NA	P	Molybdenum transport system permease protein ModB
C1_02444	155864.EDL933_0837	4.4e-138	497.3	Escherichia	modA	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015098,GO:0015103,GO:0015318,GO:0015399,GO:0015405,GO:0015412,GO:0015689,GO:0015698,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0030151,GO:0030288,GO:0030313,GO:0030973,GO:0031975,GO:0034220,GO:0042597,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043169,GO:0043225,GO:0043492,GO:0044464,GO:0046872,GO:0046914,GO:0051179,GO:0051234,GO:0055085,GO:0098656,GO:0099133,GO:1901359		ko:K02020	ko02010,map02010	M00189			ko00000,ko00001,ko00002,ko02000	3.A.1.8		iAF987.Gmet_0512,iECO111_1330.ECO111_0773,iPC815.YPO1145	Bacteria	1MVNA@1224,1RN71@1236,3XP51@561,COG0725@1,COG0725@2	NA|NA|NA	P	Molybdate-binding periplasmic
C1_02445	155864.EDL933_0836	3.1e-16	90.1	Escherichia	acrZ												Bacteria	1NHYI@1224,1SGXU@1236,2EGRQ@1,33AHW@2,3XQ3R@561	NA|NA|NA	U	AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export
C1_02446	155864.EDL933_0835	1.4e-139	502.3	Escherichia	modE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K02019,ko:K05772	ko02010,map02010	M00186			ko00000,ko00001,ko00002,ko02000,ko03000	3.A.1.6.2,3.A.1.6.4			Bacteria	1P9SX@1224,1RMES@1236,3XMNJ@561,COG2005@1,COG2005@2,COG3585@1,COG3585@2	NA|NA|NA	K	The ModE-Mo complex acts as a repressor of the modABC operon, involved in the transport of molybdate. Upon binding molybdate, the conformation of the protein changes, promoting dimerization of ModE-Mo. The protein dimer is then competent to bind a DNA region, upstream of the modABC operon
C1_02447	155864.EDL933_0834	7.2e-275	952.6	Escherichia	modF	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	3.6.3.21,3.6.3.34	ko:K02013,ko:K02028,ko:K05776	ko02010,map02010	M00189,M00236,M00240			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14,3.A.1.3			Bacteria	1MVVM@1224,1RMXK@1236,3XNSI@561,COG1119@1,COG1119@2	NA|NA|NA	P	Involved in the transport of molybdenum into the cell. Involved in photorepair. Could act on UV-induced DNA damage other than pyrimidine dimers
C1_02448	155864.EDL933_0833	9.9e-199	699.1	Escherichia	galE	GO:0000166,GO:0000271,GO:0003674,GO:0003824,GO:0003978,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005996,GO:0006012,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009242,GO:0009987,GO:0016051,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019318,GO:0019320,GO:0019388,GO:0033499,GO:0033692,GO:0034637,GO:0034645,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046377,GO:0048037,GO:0050662,GO:0051287,GO:0070403,GO:0071704,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901575,GO:1901576	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000			iPC815.YPO1139,iSF_1195.SF0545,iSFxv_1172.SFxv_0601,iS_1188.S0553,iYL1228.KPN_00773	Bacteria	1MUHI@1224,1RMTU@1236,3XP3B@561,COG1087@1,COG1087@2	NA|NA|NA	M	UDP-glucose 4-epimerase
C1_02449	754331.AEME01000001_gene1442	1.6e-207	728.4	Escherichia	galT	GO:0003674,GO:0003824,GO:0004335,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006012,GO:0006793,GO:0006796,GO:0008108,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016779,GO:0019200,GO:0019318,GO:0019320,GO:0019388,GO:0033499,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046835,GO:0046872,GO:0046914,GO:0070569,GO:0071704,GO:1901575	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000			iECUMN_1333.ECUMN_0842,iYL1228.KPN_00772	Bacteria	1MU3E@1224,1RMDK@1236,3XM5X@561,COG1085@1,COG1085@2	NA|NA|NA	C	Belongs to the galactose-1-phosphate uridylyltransferase type 1 family
C1_02450	155864.EDL933_0831	2e-216	758.1	Escherichia	galK	GO:0000287,GO:0003674,GO:0003824,GO:0004335,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006012,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019318,GO:0019320,GO:0019388,GO:0033499,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046835,GO:0046872,GO:0071704,GO:1901575	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147			iAF1260.b0757,iAPECO1_1312.APECO1_1331,iBWG_1329.BWG_0609,iEC55989_1330.EC55989_0736,iECABU_c1320.ECABU_c07960,iECB_1328.ECB_00710,iECDH1ME8569_1439.ECDH1ME8569_0710,iECH74115_1262.ECH74115_0860,iECIAI1_1343.ECIAI1_0725,iECNA114_1301.ECNA114_0687,iECO103_1326.ECO103_0745,iECOK1_1307.ECOK1_0757,iECP_1309.ECP_0768,iECS88_1305.ECS88_0773,iECSE_1348.ECSE_0810,iECSF_1327.ECSF_0683,iECSP_1301.ECSP_0810,iECW_1372.ECW_m0812,iECs_1301.ECs0785,iEKO11_1354.EKO11_3129,iETEC_1333.ETEC_0761,iEcDH1_1363.EcDH1_2885,iEcE24377_1341.EcE24377A_0784,iEcolC_1368.EcolC_2905,iG2583_1286.G2583_0923,iJO1366.b0757,iJR904.b0757,iLF82_1304.LF82_0794,iNRG857_1313.NRG857_03350,iUMN146_1321.UM146_13870,iUMNK88_1353.UMNK88_796,iUTI89_1310.UTI89_C0754,iWFL_1372.ECW_m0812,iY75_1357.Y75_RS03945,ic_1306.c0833	Bacteria	1MVQD@1224,1RQ0C@1236,3XP8E@561,COG0153@1,COG0153@2	NA|NA|NA	F	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C1_02451	198214.SF0548	8e-204	716.1	Gammaproteobacteria	galM	GO:0003674,GO:0003824,GO:0004034,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005996,GO:0006006,GO:0006012,GO:0008150,GO:0008152,GO:0009056,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019318,GO:0019320,GO:0019388,GO:0033499,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046365,GO:0071704,GO:1901575	2.7.1.6,5.1.3.3	ko:K00849,ko:K01785	ko00010,ko00052,ko00520,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map00520,map01100,map01110,map01120,map01130	M00554,M00632	R01092,R01602,R10619	RC00002,RC00078,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147			iECH74115_1262.ECH74115_0859,iECSP_1301.ECSP_0809,iECs_1301.ECs0784,iZ_1308.Z0926	Bacteria	1MVMN@1224,1RNZN@1236,COG2017@1,COG2017@2	NA|NA|NA	G	converts alpha-aldose to the beta-anomer
C1_02452	155864.EDL933_0828	2.8e-142	511.1	Escherichia	gpmA	GO:0001871,GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009986,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0030246,GO:0030247,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031,GO:2001065	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147				Bacteria	1MUVE@1224,1RNCX@1236,3XMC6@561,COG0588@1,COG0588@2	NA|NA|NA	F	Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily
C1_02453	155864.EDL933_0827	3.2e-200	704.1	Escherichia	aroG	GO:0003674,GO:0003824,GO:0003849,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019438,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_3932,iECNA114_1301.ECNA114_0684,iECOK1_1307.ECOK1_2946,iECS88_1305.ECS88_2787,iECSF_1327.ECSF_0680,iEcSMS35_1347.EcSMS35_0777,iLF82_1304.LF82_0146,iNRG857_1313.NRG857_03335,iSbBS512_1146.SbBS512_E1908,iUMN146_1321.UM146_03705,iYL1228.KPN_00758	Bacteria	1MU5Q@1224,1RMAA@1236,3XMQ0@561,COG0722@1,COG0722@2	NA|NA|NA	E	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1_02454	198214.SF0551	8.9e-60	236.1	Gammaproteobacteria	ybgS												Bacteria	1REV6@1224,1S3VK@1236,2AAK7@1,30ZXQ@2	NA|NA|NA	S	YbgS-like protein
C1_02455	316407.4062324	1.2e-174	619.0	Escherichia	zitB	GO:0000041,GO:0003674,GO:0005215,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008150,GO:0008324,GO:0015075,GO:0015318,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0044464,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662		ko:K16264					ko00000,ko02000	2.A.4.1		iNRG857_1313.NRG857_03325,iPC815.YPO1129	Bacteria	1MVQB@1224,1RMR8@1236,3XMQK@561,COG1230@1,COG1230@2	NA|NA|NA	P	Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc
C1_02456	198214.SF0553	2.7e-126	458.0	Gammaproteobacteria	pnuC	GO:0003674,GO:0005215,GO:0005337,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0015858,GO:0015931,GO:0015932,GO:0016020,GO:0022857,GO:0034257,GO:0034258,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:1901264,GO:1901505,GO:1901642		ko:K03811					ko00000,ko02000	4.B.1.1		iSDY_1059.SDY_0695	Bacteria	1MXN4@1224,1RMZE@1236,COG3201@1,COG3201@2	NA|NA|NA	H	nicotinamide mononucleotide transporter
C1_02457	316407.1651334	7.8e-199	699.5	Escherichia	nadA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000			iAF1260.b0750,iAPECO1_1312.APECO1_1338,iB21_1397.B21_00692,iBWG_1329.BWG_0602,iECBD_1354.ECBD_2917,iECB_1328.ECB_00703,iECDH10B_1368.ECDH10B_0817,iECDH1ME8569_1439.ECDH1ME8569_0703,iECD_1391.ECD_00703,iECED1_1282.ECED1_0711,iECOK1_1307.ECOK1_0750,iECP_1309.ECP_0761,iECS88_1305.ECS88_0766,iECSP_1301.ECSP_0802,iECs_1301.ECs0778,iETEC_1333.ETEC_0754,iEcDH1_1363.EcDH1_2892,iEcolC_1368.EcolC_2912,iJN746.PP_1231,iJO1366.b0750,iJR904.b0750,iUMN146_1321.UM146_13905,iUTI89_1310.UTI89_C0747,iY75_1357.Y75_RS03905,iZ_1308.Z0919	Bacteria	1MWQU@1224,1RMFS@1236,3XMW5@561,COG0379@1,COG0379@2	NA|NA|NA	F	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C1_02465	469008.B21_00691	8.8e-94	350.1	Escherichia	cpoB	GO:0005575,GO:0005623,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043933,GO:0044085,GO:0044464,GO:0051259,GO:0051260,GO:0051301,GO:0065003,GO:0071840	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036				Bacteria	1MUSV@1224,1RQWA@1236,3XMDS@561,COG1729@1,COG1729@2	NA|NA|NA	D	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C1_02466	155864.EDL933_0821	1.5e-89	335.5	Escherichia	pal	GO:0005575,GO:0005623,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032153,GO:0044425,GO:0044462,GO:0044464,GO:0051301,GO:0071944,GO:0098552		ko:K03640					ko00000,ko02000	2.C.1.2			Bacteria	1MZTV@1224,1S8RG@1236,3XMTD@561,COG2885@1,COG2885@2	NA|NA|NA	M	Thought to play a role in bacterial envelope integrity. Very strongly associated with the peptidoglycan
C1_02467	155864.EDL933_0820	6.8e-168	597.0	Escherichia	tolB	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0009719,GO:0009987,GO:0010033,GO:0010243,GO:0015031,GO:0015833,GO:0015893,GO:0017038,GO:0019534,GO:0019904,GO:0022857,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0032991,GO:0033036,GO:0042221,GO:0042493,GO:0042597,GO:0042886,GO:0042891,GO:0043213,GO:0044464,GO:0044877,GO:0045184,GO:0046677,GO:0046678,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0070887,GO:0071236,GO:0071237,GO:0071310,GO:0071417,GO:0071495,GO:0071702,GO:0071705,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1901998		ko:K03641					ko00000,ko02000	2.C.1.2			Bacteria	1MV09@1224,1RMCY@1236,3XP8Z@561,COG0823@1,COG0823@2	NA|NA|NA	U	Involved in the TonB-independent uptake of
C1_02468	316407.1651331	2.9e-93	349.0	Escherichia	tolA	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0009719,GO:0009987,GO:0010033,GO:0010243,GO:0015031,GO:0015833,GO:0015893,GO:0016020,GO:0016021,GO:0016032,GO:0017038,GO:0019058,GO:0019904,GO:0030260,GO:0031224,GO:0031226,GO:0032153,GO:0033036,GO:0042221,GO:0042493,GO:0042886,GO:0042891,GO:0043213,GO:0044403,GO:0044409,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046677,GO:0046678,GO:0046718,GO:0046790,GO:0050896,GO:0051179,GO:0051234,GO:0051301,GO:0051701,GO:0051704,GO:0051716,GO:0051806,GO:0051828,GO:0070887,GO:0071236,GO:0071237,GO:0071310,GO:0071417,GO:0071495,GO:0071702,GO:0071705,GO:0071944,GO:0097718,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701		ko:K03646					ko00000,ko02000	2.C.1.2			Bacteria	1MVQS@1224,1RP2V@1236,3XNNC@561,COG3064@1,COG3064@2	NA|NA|NA	U	Involved in the TonB-independent uptake of group A colicins (colicins A, E1, E2, E3, and K). Necessary for the colicins to reach their respective targets after initial binding to the bacteria. Also involved in the translocation of bacteriophage DNA
C1_02469	155864.EDL933_0818	3.1e-69	267.7	Escherichia	tolR	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032153,GO:0042221,GO:0042493,GO:0042886,GO:0042891,GO:0043213,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944		ko:K03560					ko00000,ko02000	1.A.30.2.2			Bacteria	1MZ6M@1224,1S8RS@1236,3XPID@561,COG0848@1,COG0848@2	NA|NA|NA	U	involved in the tonB-independent uptake of group A colicins
C1_02470	1440052.EAKF1_ch0731c	3.1e-119	434.5	Escherichia	tolQ	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0015893,GO:0016020,GO:0016021,GO:0017038,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0032153,GO:0033036,GO:0042221,GO:0042493,GO:0042886,GO:0042891,GO:0043213,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944		ko:K03562	ko01120,map01120				ko00000,ko02000	1.A.30.2.2			Bacteria	1NCWW@1224,1RMD4@1236,3XN9R@561,COG0811@1,COG0811@2	NA|NA|NA	U	Involved in the TonB-independent uptake of
C1_02471	1440052.EAKF1_ch0732c	3.2e-68	264.2	Escherichia	ybgC	GO:0003674,GO:0003824,GO:0016787,GO:0016788,GO:0016790		ko:K07107,ko:K12500					ko00000,ko01000,ko01004			iECP_1309.ECP_0747,iSDY_1059.SDY_0684	Bacteria	1MZH6@1224,1S93F@1236,3XPK1@561,COG0824@1,COG0824@2	NA|NA|NA	S	Thioesterase-like superfamily
C1_02472	155864.EDL933_0815	2.3e-47	194.5	Escherichia	ybgE											iECW_1372.ECW_m0790,iWFL_1372.ECW_m0790	Bacteria	1MZDH@1224,1SA3Q@1236,3XPW9@561,COG3790@1,COG3790@2	NA|NA|NA	S	Cyd operon protein YbgE (Cyd_oper_YbgE)
C1_02473	1440052.EAKF1_ch0734c	9.1e-13	78.2	Proteobacteria	ybgT	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008152,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0019867,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0055114,GO:0071944	1.10.3.14	ko:K00424	ko00190,ko02020,map00190,map02020	M00153			ko00000,ko00001,ko01000	3.D.4.3			Bacteria	1NGDQ@1224,COG4890@1,COG4890@2	NA|NA|NA	S	Cyd operon protein YbgT
C1_02474	155864.EDL933_0813	1.6e-213	748.4	Escherichia	cydB	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0016682,GO:0019646,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0070069,GO:0071944,GO:0097159,GO:1901363	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3		iECABU_c1320.ECABU_c10120,iLF82_1304.LF82_0101,iNRG857_1313.NRG857_04455,iPC815.YPO1118,iYO844.BSU38750,ic_1306.c1120	Bacteria	1MURP@1224,1RP7F@1236,3XN5E@561,COG1294@1,COG1294@2	NA|NA|NA	C	A terminal oxidase that produces a proton motive force by the vectorial transfer of protons across the inner membrane. It is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at low aeration. Generates a proton motive force using protons and electrons from opposite sides of the membrane to generate H(2)O, transferring 1 proton electron
C1_02475	155864.EDL933_0812	3.9e-295	1020.0	Escherichia	cydA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0019646,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0070069,GO:0071944,GO:0097159,GO:1901363	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3		iPC815.YPO1117,iSBO_1134.SBO_2253,iSFxv_1172.SFxv_0621,iS_1188.S0577,iSbBS512_1146.SbBS512_E2337	Bacteria	1MV60@1224,1RN2U@1236,3XNDG@561,COG1271@1,COG1271@2	NA|NA|NA	C	A terminal oxidase that produces a proton motive force by the vectorial transfer of protons across the inner membrane. It is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at low aeration. Generates a proton motive force using protons and electrons from opposite sides of the membrane to generate H(2)O, transferring 1 proton electron
C1_02476	316407.4062319	0.0	1758.4	Gammaproteobacteria	mngB	GO:0003674,GO:0003824,GO:0004553,GO:0004559,GO:0005975,GO:0005996,GO:0006013,GO:0006464,GO:0006517,GO:0006807,GO:0008150,GO:0008152,GO:0009100,GO:0009987,GO:0015923,GO:0016787,GO:0016798,GO:0019318,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0071704,GO:1901135,GO:1901564	3.2.1.170	ko:K15524					ko00000,ko01000		GH38	iEcolC_1368.EcolC_2924,iSF_1195.SF0565,iSFxv_1172.SFxv_0623,iS_1188.S0578	Bacteria	1R3Q8@1224,1RSGZ@1236,COG0383@1,COG0383@2	NA|NA|NA	G	Alpha-Mannosidase
C1_02477	316407.85674750	0.0	1176.4	Escherichia	hrsA	GO:0001932,GO:0001934,GO:0003674,GO:0003824,GO:0004857,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0006810,GO:0006811,GO:0006820,GO:0008047,GO:0008150,GO:0008152,GO:0008643,GO:0009058,GO:0009059,GO:0009401,GO:0009893,GO:0009987,GO:0010033,GO:0010243,GO:0010467,GO:0010562,GO:0010604,GO:0015144,GO:0015711,GO:0015749,GO:0015791,GO:0015796,GO:0015849,GO:0015850,GO:0015882,GO:0016020,GO:0016021,GO:0016070,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019207,GO:0019209,GO:0019220,GO:0019222,GO:0019438,GO:0019887,GO:0022804,GO:0022857,GO:0022898,GO:0030234,GO:0030295,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031399,GO:0031401,GO:0032147,GO:0032268,GO:0032270,GO:0032409,GO:0032412,GO:0032774,GO:0032879,GO:0033674,GO:0034219,GO:0034220,GO:0034641,GO:0034645,GO:0034654,GO:0034762,GO:0034765,GO:0035461,GO:0042221,GO:0042325,GO:0042327,GO:0043085,GO:0043086,GO:0043170,GO:0043269,GO:0043549,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045859,GO:0045860,GO:0045937,GO:0046483,GO:0046942,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051049,GO:0051171,GO:0051173,GO:0051174,GO:0051179,GO:0051180,GO:0051181,GO:0051182,GO:0051234,GO:0051246,GO:0051247,GO:0051338,GO:0051347,GO:0051476,GO:0055085,GO:0060255,GO:0065007,GO:0065009,GO:0071702,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0090563,GO:0090581,GO:0090584,GO:0090585,GO:0097659,GO:0098656,GO:0098772,GO:1901264,GO:1901360,GO:1901362,GO:1901576,GO:1901656,GO:1901698,GO:1903825,GO:1905039	2.7.1.194,2.7.1.195,2.7.1.197,2.7.1.200,2.7.1.202,2.7.3.9	ko:K02768,ko:K02769,ko:K02770,ko:K02773,ko:K02798,ko:K02806,ko:K02821,ko:K08483,ko:K11189,ko:K11198,ko:K11199,ko:K11200,ko:K11201,ko:K18531	ko00051,ko00052,ko00053,ko01100,ko01120,ko02060,map00051,map00052,map00053,map01100,map01120,map02060	M00273,M00274,M00279,M00283,M00305,M00306,M00550	R02704,R03232,R05570,R07671,R11169	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1,4.A.2.1.12,4.A.2.1.2,4.A.2.1.24,4.A.2.1.3,4.A.2.1.5,4.A.5.1,4.A.7.1,8.A.7		iECABU_c1320.ECABU_c47530,iECO26_1355.ECO26_0791,iECUMN_1333.ECUMN_4728,iEcSMS35_1347.EcSMS35_4666,ic_1306.c5284	Bacteria	1PF9N@1224,1RQCI@1236,3XRKC@561,COG1299@1,COG1299@2,COG1445@1,COG1445@2,COG1762@1,COG1762@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in mannosyl-D-glycerate transport. Also involved in thermoinduction of ompC
C1_02478	198214.SF0567	6.3e-131	473.4	Gammaproteobacteria	mngR	GO:0003674,GO:0003700,GO:0006355,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K03482,ko:K03710,ko:K11922					ko00000,ko03000				Bacteria	1MUEB@1224,1RRAM@1236,COG2188@1,COG2188@2	NA|NA|NA	K	Transcriptional regulator
C1_02479	155864.EDL933_0798	1.1e-158	565.8	Escherichia	sucD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009361,GO:0009987,GO:0016310,GO:0019538,GO:0032991,GO:0036211,GO:0042709,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0046777,GO:0071704,GO:1901564,GO:1902494	6.2.1.5	ko:K01902,ko:K02381	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000			iE2348C_1286.E2348C_0608	Bacteria	1MUGA@1224,1RM7Y@1236,3XPB9@561,COG0074@1,COG0074@2	NA|NA|NA	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C1_02480	155864.EDL933_0797	2.5e-214	751.1	Escherichia	sucC	GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009361,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0032991,GO:0042709,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045333,GO:0055114,GO:0071704,GO:0072350,GO:1902494	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000			iPC815.YPO1115,iUMNK88_1353.UMNK88_764	Bacteria	1MVCE@1224,1RMSU@1236,3XMIP@561,COG0045@1,COG0045@2	NA|NA|NA	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
C1_02481	155864.EDL933_0796	1.7e-213	748.4	Escherichia	sucB	GO:0003674,GO:0003824,GO:0004149,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008289,GO:0009060,GO:0009987,GO:0015980,GO:0016417,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016751,GO:0016999,GO:0017144,GO:0019752,GO:0031405,GO:0031406,GO:0032991,GO:0033293,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0048037,GO:0050662,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:0140096,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_2766,iAPECO1_1312.APECO1_1352,iECED1_1282.ECED1_0696,iECOK1_1307.ECOK1_0726,iECS88_1305.ECS88_0752,iLF82_1304.LF82_2196,iNRG857_1313.NRG857_03235,iUMN146_1321.UM146_13990,iUTI89_1310.UTI89_C0722	Bacteria	1MUJD@1224,1RME0@1236,3XP92@561,COG0508@1,COG0508@2	NA|NA|NA	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)
C1_02482	155864.EDL933_0795	0.0	1893.2	Escherichia	sucA	GO:0000287,GO:0003674,GO:0003824,GO:0004591,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016624,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0019842,GO:0022900,GO:0030312,GO:0030976,GO:0032991,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0048037,GO:0050439,GO:0050662,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234	1.2.4.2,4.1.1.71	ko:K00164,ko:K01616	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000			iNJ661.Rv1248c,iSSON_1240.SSON_0677,iYL1228.KPN_00732	Bacteria	1MVBF@1224,1RN8K@1236,3XMF3@561,COG0567@1,COG0567@2	NA|NA|NA	F	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)
C1_02483	1440052.EAKF1_ch0744c	8.1e-139	499.6	Escherichia	sdhB	GO:0000104,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0022904,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045333,GO:0048037,GO:0051536,GO:0051537,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072350,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.3.5.1,1.3.5.4	ko:K00240,ko:K00245	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000			e_coli_core.b0724,iAF1260.b0724,iBWG_1329.BWG_0583,iEC042_1314.EC042_0742,iECDH10B_1368.ECDH10B_0791,iECDH1ME8569_1439.ECDH1ME8569_0683,iECUMN_1333.ECUMN_0802,iEcDH1_1363.EcDH1_2911,iJO1366.b0724,iJR904.b0724,iSDY_1059.SDY_4397,iY75_1357.Y75_RS03765	Bacteria	1MVHS@1224,1RNWR@1236,3XNT4@561,COG0479@1,COG0479@2	NA|NA|NA	C	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C1_02484	155864.EDL933_0792	0.0	1191.8	Escherichia	sdhA	GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0043436,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071704,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0072350,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000			iE2348C_1286.E2348C_0603,iJN746.PP_4191,iPC815.YPO1111	Bacteria	1MU5M@1224,1RMU2@1236,3XNV2@561,COG1053@1,COG1053@2	NA|NA|NA	C	the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth
C1_02485	198214.SF0575	4e-51	207.2	Gammaproteobacteria	sdhD	GO:0000104,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0016999,GO:0017004,GO:0017144,GO:0019752,GO:0020037,GO:0022607,GO:0022900,GO:0032991,GO:0034622,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0065003,GO:0070469,GO:0070470,GO:0071704,GO:0071840,GO:0071944,GO:0072350,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901363,GO:1902494,GO:1990204		ko:K00242	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173	R02164	RC00045	ko00000,ko00001,ko00002			e_coli_core.b0722,iAF1260.b0722,iAPECO1_1312.APECO1_1356,iB21_1397.B21_00671,iBWG_1329.BWG_0581,iE2348C_1286.E2348C_0602,iEC042_1314.EC042_0740,iECABU_c1320.ECABU_c07680,iECBD_1354.ECBD_2938,iECB_1328.ECB_00682,iECDH10B_1368.ECDH10B_0789,iECDH1ME8569_1439.ECDH1ME8569_0681,iECD_1391.ECD_00682,iECED1_1282.ECED1_0692,iECIAI1_1343.ECIAI1_0696,iECIAI39_1322.ECIAI39_0680,iECNA114_1301.ECNA114_0658,iECO103_1326.ECO103_0716,iECO111_1330.ECO111_0739,iECO26_1355.ECO26_0783,iECOK1_1307.ECOK1_0722,iECP_1309.ECP_0734,iECS88_1305.ECS88_0748,iECSE_1348.ECSE_0782,iECSF_1327.ECSF_0655,iECUMN_1333.ECUMN_0800,iECW_1372.ECW_m0777,iEKO11_1354.EKO11_3157,iETEC_1333.ETEC_0733,iEcDH1_1363.EcDH1_2913,iEcE24377_1341.EcE24377A_0749,iEcHS_1320.EcHS_A0770,iEcSMS35_1347.EcSMS35_0735,iEcolC_1368.EcolC_2933,iJO1366.b0722,iJR904.b0722,iLF82_1304.LF82_2100,iNRG857_1313.NRG857_03215,iSBO_1134.SBO_0580,iSDY_1059.SDY_0660,iSFV_1184.SFV_0613,iSF_1195.SF0575,iSFxv_1172.SFxv_0634,iSSON_1240.SSON_0673,iS_1188.S0588,iUMN146_1321.UM146_14010,iUMNK88_1353.UMNK88_758,iUTI89_1310.UTI89_C0718,iWFL_1372.ECW_m0777,iY75_1357.Y75_RS03755,ic_1306.c0800	Bacteria	1MZR9@1224,1S9TS@1236,COG2142@1,COG2142@2	NA|NA|NA	C	Succinate dehydrogenase hydrophobic membrane anchor subunit
C1_02486	481805.EcolC_2934	9.7e-65	252.7	Escherichia	sdhC	GO:0000104,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0008177,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0016635,GO:0017004,GO:0020037,GO:0022607,GO:0022900,GO:0034622,GO:0043933,GO:0044085,GO:0044237,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0048038,GO:0048039,GO:0055114,GO:0065003,GO:0071840,GO:0071944,GO:0097159,GO:1901363		ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002			iSF_1195.SF0576,iS_1188.S0589	Bacteria	1RIGZ@1224,1S5ZE@1236,3XPJC@561,COG2009@1,COG2009@2	NA|NA|NA	C	Succinate dehydrogenase cytochrome b556 subunit
C1_02488	199310.c0796	4.1e-250	870.2	Escherichia	gltA	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0042802,GO:0044424,GO:0044444,GO:0044464	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000			iIT341.HP0026,iYL1228.KPN_00727	Bacteria	1MUKX@1224,1RNDK@1236,3XMKA@561,COG0372@1,COG0372@2	NA|NA|NA	C	Belongs to the citrate synthase family
C1_02489	481805.EcolC_2936	8.5e-99	366.3	Escherichia	ybgD			ko:K07345	ko05133,map05133				ko00000,ko00001,ko02035,ko02044				Bacteria	1N3XD@1224,1SBRY@1236,3XQQJ@561,COG3539@1,COG3539@2	NA|NA|NA	NU	cell adhesion
C1_02490	481805.EcolC_2937	0.0	1640.6	Escherichia	ybgQ	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0009279,GO:0009297,GO:0009987,GO:0015267,GO:0015288,GO:0015473,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0022803,GO:0022829,GO:0022857,GO:0030030,GO:0030031,GO:0030312,GO:0030313,GO:0031975,GO:0043711,GO:0044085,GO:0044462,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071840,GO:0071944											Bacteria	1P744@1224,1RN8Z@1236,3XMSW@561,COG3188@1,COG3188@2	NA|NA|NA	NU	outer membrane usher protein
C1_02491	198214.SF0580	2.8e-134	484.6	Gammaproteobacteria	ybgP	GO:0006457,GO:0008150,GO:0009987		ko:K07346,ko:K07353					ko00000,ko02035,ko02044,ko03110				Bacteria	1MY06@1224,1RN7Y@1236,COG3121@1,COG3121@2	NA|NA|NA	M	chaperone
C1_02492	481805.EcolC_2939	7.4e-205	719.5	Escherichia	ybgO												Bacteria	1R706@1224,1S0UV@1236,3XND1@561,COG3539@1,COG3539@2	NA|NA|NA	NU	May be involved in a fimbrial system chaperoned by
C1_02493	198214.SF0582	2.8e-180	637.9	Gammaproteobacteria	abrB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K07120					ko00000				Bacteria	1MUFS@1224,1RPMJ@1236,COG3180@1,COG3180@2	NA|NA|NA	S	Ammonia monooxygenase
C1_02494	316407.4062310	2.3e-150	538.1	Escherichia	nei	GO:0000702,GO:0000703,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003824,GO:0003906,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	4.2.99.18	ko:K05522	ko03410,map03410				ko00000,ko00001,ko01000,ko03400				Bacteria	1N1J5@1224,1RNS9@1236,3XPFM@561,COG0266@1,COG0266@2	NA|NA|NA	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates
C1_02495	198214.SF0584	3.2e-130	471.1	Gammaproteobacteria	ybgL			ko:K07160					ko00000				Bacteria	1MUYV@1224,1RSCZ@1236,COG1540@1,COG1540@2	NA|NA|NA	E	Belongs to the UPF0271 (lamB) family
C1_02496	155864.EDL933_0778	1.5e-180	638.6	Escherichia	ybgK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	3.5.1.54,6.3.4.6	ko:K01457,ko:K01941	ko00220,ko00791,ko01100,ko01120,map00220,map00791,map01100,map01120		R00005,R00774	RC00378,RC02756	ko00000,ko00001,ko01000				Bacteria	1MU9H@1224,1RR39@1236,3XNFI@561,COG1984@1,COG1984@2	NA|NA|NA	E	5-oxoprolinase (ATP-hydrolyzing) activity
C1_02497	155864.EDL933_0777	2.8e-122	444.5	Escherichia	kipI		3.5.1.54	ko:K01457,ko:K06351,ko:K07160	ko00220,ko00791,ko01100,ko01120,map00220,map00791,map01100,map01120		R00005	RC02756	ko00000,ko00001,ko01000				Bacteria	1MWRB@1224,1RQIQ@1236,3XNDW@561,COG2049@1,COG2049@2	NA|NA|NA	E	5-oxoprolinase (ATP-hydrolyzing) activity
C1_02498	155864.EDL933_0776	4e-141	507.3	Escherichia	ybgI	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0042802,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0050896	3.5.4.16	ko:K22391	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000				Bacteria	1MVUN@1224,1RNBU@1236,3XP2E@561,COG0327@1,COG0327@2	NA|NA|NA	S	Provides significant protection from radiation damage and may be involved in the degradation of radiation-damaged nucleotides
C1_02499	198214.SF0588	2.9e-279	967.2	Gammaproteobacteria	dtpD	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008150,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0042886,GO:0042938,GO:0044425,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944		ko:K03305					ko00000	2.A.17		iECO103_1326.ECO103_0702	Bacteria	1MW6W@1224,1RM8P@1236,COG3104@1,COG3104@2	NA|NA|NA	U	Proton-dependent permease that transports di- and tripeptides
C1_02500	469008.B21_00657	8.5e-281	972.2	Escherichia	phrB	GO:0003674,GO:0003824,GO:0003904,GO:0003913,GO:0006139,GO:0006259,GO:0006281,GO:0006464,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0018298,GO:0019538,GO:0033554,GO:0034641,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901564	4.1.99.3	ko:K01669					ko00000,ko01000,ko03400				Bacteria	1MV9Y@1224,1RNGJ@1236,3XMSK@561,COG0415@1,COG0415@2	NA|NA|NA	L	Deoxyribodipyrimidine photo-lyase
C1_02501	469008.B21_00656	2.7e-96	357.8	Escherichia	ybgA												Bacteria	1MXYZ@1224,1RNMF@1236,3XNUT@561,COG3272@1,COG3272@2	NA|NA|NA	S	Protein of unknown function (DUF1722)
C1_02502	481805.EcolC_2949	5.8e-123	446.8	Gammaproteobacteria	ybfD												Bacteria	1MXB5@1224,1RSAV@1236,COG5433@1,COG5433@2	NA|NA|NA	L	Transposase
C1_02503	316407.4062297	3.3e-42	177.2	Gammaproteobacteria													Bacteria	1MXB5@1224,1RSAV@1236,COG5433@1,COG5433@2	NA|NA|NA	L	Transposase
C1_02504	316407.4062296	5.2e-104	383.6	Gammaproteobacteria	ybfC												Bacteria	1NUYT@1224,1SNRB@1236,2F2KC@1,33VH6@2	NA|NA|NA		
C1_02505	316407.1651310	3.8e-289	1000.0	Bacteria	ybfO	GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010438,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042594,GO:0050896,GO:0051716,GO:0071496											Bacteria	COG3209@1,COG3209@2	NA|NA|NA	M	self proteolysis
C1_02506	316407.4062295	3e-48	197.6	Gammaproteobacteria	ybfB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1P7KU@1224,1SUIK@1236,28UM6@1,2ZGRQ@2	NA|NA|NA		
C1_02507	481805.EcolC_2955	0.0	2416.0	Escherichia	rhsC												Bacteria	1MVV1@1224,1SKYM@1236,3XQSX@561,COG3209@1,COG3209@2	NA|NA|NA	M	Rhs elements have a nonessential function. They may play an important role in the natural ecology of the cell
C1_02508	155864.EDL933_0769	8.5e-33	145.6	Escherichia	ybfA	GO:0008150,GO:0009314,GO:0009628,GO:0050896											Bacteria	1N75R@1224,1SCNU@1236,2E70C@1,331J8@2,3XPZX@561	NA|NA|NA	S	response to radiation
C1_02509	469008.B21_00646	3.7e-307	1060.1	Escherichia	kdpA	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0030955,GO:0031004,GO:0031224,GO:0031226,GO:0031420,GO:0032991,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090533,GO:0090662,GO:0098533,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1902494,GO:1902495,GO:1904949,GO:1990351	3.6.3.12	ko:K01546	ko02020,map02020				ko00000,ko00001,ko01000	3.A.3.7		iAPECO1_1312.APECO1_1369,iECUMN_1333.ECUMN_0780,iYL1228.KPN_00717	Bacteria	1MV1K@1224,1RQZU@1236,3XM6D@561,COG2060@1,COG2060@2	NA|NA|NA	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C1_02510	316407.85674743	0.0	1274.2	Escherichia	kdpB	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031004,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090533,GO:0090662,GO:0098533,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1902494,GO:1902495,GO:1904949,GO:1990351	3.6.3.12	ko:K01547	ko02020,map02020				ko00000,ko00001,ko01000	3.A.3.7		iAF987.Gmet_2434,iECNA114_1301.ECNA114_0634,iECSF_1327.ECSF_0632	Bacteria	1MU7D@1224,1RPPF@1236,3XMHA@561,COG2216@1,COG2216@2	NA|NA|NA	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C1_02511	469008.B21_00644	5.9e-100	370.2	Gammaproteobacteria	kdpC	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031004,GO:0031224,GO:0032991,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090533,GO:0090662,GO:0098533,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1902494,GO:1902495,GO:1904949,GO:1990351	3.6.3.12	ko:K01548	ko02020,map02020				ko00000,ko00001,ko01000	3.A.3.7		iEcE24377_1341.EcE24377A_0722,ic_1306.c0781	Bacteria	1RABG@1224,1RZ90@1236,COG2156@1,COG2156@2	NA|NA|NA	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C1_02512	469008.B21_00643	0.0	1744.9	Escherichia													Bacteria	1MUZQ@1224,1RMZT@1236,3XMJ0@561,COG0642@1,COG2205@2	NA|NA|NA	T	PhoQ Sensor
C1_02513	199310.c0779	3.8e-122	444.1	Escherichia													Bacteria	1MWZ5@1224,1RNY2@1236,3XP6Y@561,COG0745@1,COG0745@2	NA|NA|NA	K	KDP operon transcriptional regulatory protein KdpE
C1_02515	199310.c0777	0.0	1491.1	Escherichia	speF	GO:0003674,GO:0003824,GO:0004586,GO:0005488,GO:0008144,GO:0016829,GO:0016830,GO:0016831,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	4.1.1.17,4.1.1.18,4.1.1.19	ko:K01581,ko:K01582,ko:K01584,ko:K01585	ko00310,ko00330,ko00480,ko00960,ko01100,ko01110,ko01130,map00310,map00330,map00480,map00960,map01100,map01110,map01130	M00133,M00134	R00462,R00566,R00670	RC00299	ko00000,ko00001,ko00002,ko01000			iEC042_1314.EC042_4483,iECW_1372.ECW_m0743,iEcHS_1320.EcHS_A3126,iSbBS512_1146.SbBS512_E0179,iWFL_1372.ECW_m0743	Bacteria	1MWK4@1224,1RMVF@1236,3XN9N@561,COG1982@1,COG1982@2	NA|NA|NA	E	Ornithine decarboxylase
C1_02516	199310.c0776	4e-240	837.0	Escherichia	potE	GO:0000064,GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0008519,GO:0015075,GO:0015101,GO:0015171,GO:0015179,GO:0015203,GO:0015238,GO:0015291,GO:0015293,GO:0015297,GO:0015298,GO:0015318,GO:0015489,GO:0015491,GO:0015496,GO:0015695,GO:0015696,GO:0015711,GO:0015807,GO:0015822,GO:0015846,GO:0015847,GO:0015849,GO:0015893,GO:0016020,GO:0022804,GO:0022857,GO:0034220,GO:0042221,GO:0042493,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072488,GO:0098655,GO:0098656,GO:0099516,GO:1902047,GO:1902475,GO:1903352,GO:1903825,GO:1905039		ko:K03294,ko:K03756,ko:K03757,ko:K03759					ko00000,ko02000	2.A.3.2		iAF1260.b0692,iAF1260.b4132,iAPECO1_1312.APECO1_2321,iB21_1397.B21_00640,iB21_1397.B21_03965,iBWG_1329.BWG_0551,iBWG_1329.BWG_3846,iE2348C_1286.E2348C_0581,iE2348C_1286.E2348C_4459,iEC042_1314.EC042_4498,iEC55989_1330.EC55989_4625,iECABU_c1320.ECABU_c07430,iECABU_c1320.ECABU_c46860,iECBD_1354.ECBD_2969,iECBD_1354.ECBD_3898,iECB_1328.ECB_00648,iECB_1328.ECB_04003,iECDH10B_1368.ECDH10B_0758,iECDH10B_1368.ECDH10B_4325,iECDH1ME8569_1439.ECDH1ME8569_0650,iECD_1391.ECD_00648,iECD_1391.ECD_04003,iECH74115_1262.ECH74115_5648,iECIAI1_1343.ECIAI1_0668,iECIAI1_1343.ECIAI1_4365,iECNA114_1301.ECNA114_0628,iECNA114_1301.ECNA114_4318,iECO103_1326.ECO103_0686,iECO103_1326.ECO103_4884,iECO26_1355.ECO26_0754,iECO26_1355.ECO26_5227,iECO26_1355.ECO26_5244,iECOK1_1307.ECOK1_4644,iECP_1309.ECP_0710,iECP_1309.ECP_4376,iECS88_1305.ECS88_4636,iECSE_1348.ECSE_0751,iECSE_1348.ECSE_4432,iECSF_1327.ECSF_0627,iECSF_1327.ECSF_4021,iECSP_1301.ECSP_5232,iECUMN_1333.ECUMN_4666,iECW_1372.ECW_m0742,iECW_1372.ECW_m4493,iECs_1301.ECs5114,iEKO11_1354.EKO11_3188,iEKO11_1354.EKO11_4186,iETEC_1333.ETEC_0708,iETEC_1333.ETEC_4443,iEcDH1_1363.EcDH1_2945,iEcE24377_1341.EcE24377A_4687,iEcHS_1320.EcHS_A4373,iEcSMS35_1347.EcSMS35_4601,iEcolC_1368.EcolC_2964,iEcolC_1368.EcolC_3895,iG2583_1286.G2583_4959,iJO1366.b0692,iJO1366.b4132,iJR904.b0692,iJR904.b4132,iLF82_1304.LF82_0255,iNRG857_1313.NRG857_20730,iSSON_1240.SSON_0643,iUMN146_1321.UM146_20900,iUMNK88_1353.UMNK88_4999,iUMNK88_1353.UMNK88_728,iUTI89_1310.UTI89_C4729,iWFL_1372.ECW_m0742,iWFL_1372.ECW_m4493,iY75_1357.Y75_RS03590,iY75_1357.Y75_RS21520,ic_1306.c0776,ic_1306.c5141	Bacteria	1MUA2@1224,1RPP7@1236,3XMDH@561,COG0531@1,COG0531@2	NA|NA|NA	E	Catalyzes both the uptake and excretion of putrescine. The uptake of putrescine is dependent on the membrane potential and the excretion involves putrescine-ornithine antiporter activity
C1_02517	362663.ECP_0709	0.0	1078.9	Escherichia	pgm	GO:0000271,GO:0003674,GO:0003824,GO:0004614,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0005996,GO:0006006,GO:0006012,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016052,GO:0016853,GO:0016866,GO:0016868,GO:0019318,GO:0019320,GO:0019388,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0055114,GO:0071704,GO:1901575,GO:1901576	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_1376,iECED1_1282.ECED1_0670,iECNA114_1301.ECNA114_0627,iECOK1_1307.ECOK1_0699,iECP_1309.ECP_0709,iECS88_1305.ECS88_0725,iJN678.pgm,iLF82_1304.LF82_1632,iNRG857_1313.NRG857_03110,iUMN146_1321.UM146_14115,iYL1228.KPN_00711	Bacteria	1MU5S@1224,1RPDV@1236,3XNB7@561,COG0033@1,COG0033@2	NA|NA|NA	G	phosphoglucomutase activity
C1_02518	198214.SF0606	1.2e-94	352.4	Gammaproteobacteria	seqA	GO:0000819,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006275,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008150,GO:0008156,GO:0009314,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010385,GO:0010556,GO:0010558,GO:0010605,GO:0016043,GO:0019219,GO:0019222,GO:0022402,GO:0022607,GO:0030174,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0032991,GO:0032993,GO:0042802,GO:0043565,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0044729,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0060255,GO:0065003,GO:0065007,GO:0071840,GO:0080090,GO:0090143,GO:0090329,GO:0097159,GO:0098813,GO:1901363,GO:1990097,GO:1990837,GO:2000104,GO:2000112,GO:2000113		ko:K03645					ko00000,ko03032,ko03036				Bacteria	1MUW8@1224,1RQ83@1236,COG3057@1,COG3057@2	NA|NA|NA	L	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
C1_02519	198214.SF0607	6.9e-144	516.5	Gammaproteobacteria	ybfF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016787,GO:0016788,GO:0016790,GO:0044424,GO:0044444,GO:0044464,GO:0052689		ko:K01175					ko00000,ko01000				Bacteria	1R9X7@1224,1S2CW@1236,COG0596@1,COG0596@2	NA|NA|NA	S	Alpha beta hydrolase
C1_02520	198214.SF0608	9.7e-56	222.6	Gammaproteobacteria	ybfE	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716											Bacteria	1MZBR@1224,1S9W6@1236,2DB8J@1,32TX0@2	NA|NA|NA	S	CopG domain protein DNA-binding domain protein
C1_02521	155864.EDL933_0756	1.6e-99	368.6	Escherichia	fldA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K03839,ko:K03840					ko00000			iEcSMS35_1347.EcSMS35_3028,iJN678.isiB	Bacteria	1MX7F@1224,1RMNT@1236,3XMN6@561,COG0716@1,COG0716@2	NA|NA|NA	C	Low-potential electron donor to a number of redox enzymes
C1_02522	1440052.EAKF1_ch0779	2.8e-81	307.8	Escherichia	fur	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0008270,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0043167,GO:0043169,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046872,GO:0046914,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K03711,ko:K09823	ko02024,map02024				ko00000,ko00001,ko03000				Bacteria	1RDWJ@1224,1S4H7@1236,3XMA8@561,COG0735@1,COG0735@2	NA|NA|NA	K	Acts as a global negative controlling element, employing Fe(2 ) as a cofactor to bind the operator of the repressed genes. Regulates the expression of several outer-membrane proteins including the iron transport operon
C1_02523	316407.4062283	2.9e-51	207.6	Escherichia	ybfN												Bacteria	1RHF9@1224,1S6DX@1236,2AQ40@1,31F99@2,3XPPT@561	NA|NA|NA	M	YbfN-like lipoprotein
C1_02524	469008.B21_00629	1.2e-282	978.4	Escherichia	chiP												Bacteria	1NDEQ@1224,1RMG0@1236,2C471@1,2Z7J2@2,3XPEX@561	NA|NA|NA	M	amino disaccharide metabolic process
C1_02525	316407.4062281	0.0	1146.0	Escherichia	glnS	GO:0003674,GO:0003824,GO:0004812,GO:0004819,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006425,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iECIAI39_1322.ECIAI39_0637	Bacteria	1MUC8@1224,1RQ7G@1236,3XP56@561,COG0008@1,COG0008@2	NA|NA|NA	J	glutaminyl-tRNA aminoacylation
C1_02527	155864.EDL933_0748	0.0	1229.5	Escherichia	nagE	GO:0003674,GO:0003824,GO:0005215,GO:0006810,GO:0006950,GO:0006974,GO:0008150,GO:0008643,GO:0009401,GO:0009987,GO:0015144,GO:0015764,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0033554,GO:0034219,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071702,GO:0090563,GO:0090586,GO:1901264	2.7.1.192,2.7.1.193,2.7.1.199,2.7.1.201,2.7.1.208	ko:K02749,ko:K02750,ko:K02752,ko:K02753,ko:K02777,ko:K02778,ko:K02779,ko:K02790,ko:K02791,ko:K02802,ko:K02803,ko:K02804,ko:K02818,ko:K02819,ko:K11191,ko:K11192,ko:K20107,ko:K20108,ko:K20116,ko:K20117,ko:K20118	ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111	M00265,M00266,M00267,M00268,M00270,M00272,M00303,M00806,M00809	R02738,R02780,R04111,R04394,R05132,R05199,R08559	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.1.1,4.A.1.1.10,4.A.1.1.11,4.A.1.1.12,4.A.1.1.13,4.A.1.1.14,4.A.1.1.15,4.A.1.1.16,4.A.1.1.2,4.A.1.1.3,4.A.1.1.4,4.A.1.1.5,4.A.1.1.7,4.A.1.1.8,4.A.1.1.9,4.A.1.2.13,4.A.1.2.3,4.A.1.2.4,4.A.1.2.7,4.A.1.2.8		iECABU_c1320.ECABU_c48060,iECIAI39_1322.ECIAI39_2574,iECIAI39_1322.ECIAI39_2901,iECNA114_1301.ECNA114_1668,iECP_1309.ECP_0691,iECSF_1327.ECSF_1482,ic_1306.c5339	Bacteria	1MY1V@1224,1RMYZ@1236,3XM9K@561,COG1263@1,COG1263@2,COG1264@1,COG1264@2,COG2190@1,COG2190@2	NA|NA|NA	G	PTS system, N-acetylglucosamine-specific
C1_02528	1440052.EAKF1_ch0785	9.4e-152	542.7	Escherichia	nagB	GO:0003674,GO:0003824,GO:0004342,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006040,GO:0006044,GO:0006046,GO:0006047,GO:0006048,GO:0006054,GO:0006082,GO:0006139,GO:0006725,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016054,GO:0016787,GO:0016853,GO:0016860,GO:0016861,GO:0016999,GO:0017001,GO:0017144,GO:0018130,GO:0019239,GO:0019262,GO:0019438,GO:0019752,GO:0034641,GO:0034654,GO:0042737,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046348,GO:0046349,GO:0046395,GO:0046483,GO:0055086,GO:0071704,GO:1901071,GO:1901072,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901362,GO:1901575,GO:1901576	3.1.1.31,3.5.99.6	ko:K01057,ko:K02080,ko:K02564	ko00030,ko00052,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00052,map00520,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R00765,R02035,R08365	RC00163,RC00537	ko00000,ko00001,ko00002,ko01000			iZ_1308.Z0825	Bacteria	1MVEA@1224,1RQ2V@1236,3XNCZ@561,COG0363@1,COG0363@2	NA|NA|NA	F	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
C1_02529	155864.EDL933_0745	1.8e-217	761.5	Escherichia	nagA	GO:0003674,GO:0003824,GO:0005488,GO:0006040,GO:0006044,GO:0006046,GO:0006054,GO:0006082,GO:0008150,GO:0008152,GO:0008270,GO:0008448,GO:0009056,GO:0009987,GO:0016043,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0016999,GO:0017001,GO:0017144,GO:0019213,GO:0019262,GO:0019752,GO:0022607,GO:0042737,GO:0043167,GO:0043169,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046348,GO:0046395,GO:0046872,GO:0046914,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901071,GO:1901072,GO:1901135,GO:1901136,GO:1901575	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130		R02059	RC00166,RC00300	ko00000,ko00001,ko01000			iEcolC_1368.EcolC_2979,iYL1228.KPN_00698	Bacteria	1MW8Y@1224,1RMRV@1236,3XNPT@561,COG1820@1,COG1820@2	NA|NA|NA	G	Involved in the first step in the biosynthesis of amino- sugar-nucleotides. Catalyzes the hydrolysis of the N-acetyl group of N-acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6-phosphate and acetate. In vitro, can also hydrolyze substrate analogs such as N-thioacetyl-D-glucosamine-6-phosphate, N-trifluoroacetyl-D-glucosamine-6-phosphate, N-acetyl-D- glucosamine-6-sulfate, N-acetyl-D-galactosamine-6-phosphate, and N-formyl-D-glucosamine-6-phosphate
C1_02530	155864.EDL933_0744	9.4e-228	795.8	Escherichia	nagC	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141		ko:K02565,ko:K15545					ko00000,ko03000				Bacteria	1NFM0@1224,1RNEA@1236,3XMAK@561,COG1846@1,COG1846@2,COG1940@1,COG1940@2	NA|NA|NA	K	Acts as a repressor of the nagEBACD operon and acts both as an activator and a repressor for the transcription of the glmSU operon
C1_02531	155864.EDL933_0743	3.1e-141	507.7	Escherichia	nagD	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009125,GO:0009129,GO:0009131,GO:0009158,GO:0009161,GO:0009164,GO:0009166,GO:0009173,GO:0009175,GO:0009218,GO:0009222,GO:0009259,GO:0009261,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046050,GO:0046131,GO:0046133,GO:0046135,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658		ko:K02566					ko00000				Bacteria	1QGX4@1224,1RRS1@1236,3XMSZ@561,COG0647@1,COG0647@2	NA|NA|NA	G	Catalyzes the dephosphorylation of an unusually broad range of substrate including deoxyribo- and ribonucleoside tri-, di-, and monophosphates, as well as polyphosphate and glucose-1-P (Glu1P)
C1_02532	637910.ROD_00481	2.1e-161	575.1	Gammaproteobacteria	piv			ko:K07486					ko00000				Bacteria	1MXKJ@1224,1RSCP@1236,COG3547@1,COG3547@2	NA|NA|NA	L	Transposase
C1_02533	316407.1651277	0.0	1135.9	Escherichia	asnB	GO:0000166,GO:0003674,GO:0003824,GO:0004066,GO:0004071,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006528,GO:0006529,GO:0006541,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009066,GO:0009067,GO:0009987,GO:0016053,GO:0016054,GO:0016211,GO:0016597,GO:0016874,GO:0016879,GO:0016880,GO:0016884,GO:0017076,GO:0019752,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0034641,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901607	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110		R00578	RC00010	ko00000,ko00001,ko01000,ko01002			iB21_1397.B21_00622,iECBD_1354.ECBD_2988,iECB_1328.ECB_00631,iECD_1391.ECD_00631,iEcHS_1320.EcHS_A0717,iEcolC_1368.EcolC_2982,iSF_1195.SF0619	Bacteria	1MW4E@1224,1RQ7D@1236,3XMEF@561,COG0367@1,COG0367@2	NA|NA|NA	E	Asparagine synthetase B
C1_02541	469008.B21_00621	3.9e-223	780.4	Escherichia	ubiF	GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008682,GO:0009058,GO:0009108,GO:0009987,GO:0016491,GO:0016705,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901576,GO:1901661,GO:1901663		ko:K03184,ko:K03185,ko:K18800	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04987,R04989,R06146,R08768,R08773,R08775	RC00046,RC01254,RC02670	ko00000,ko00001,ko00002,ko01000			iAF1260.b0662,iB21_1397.B21_02702,iBWG_1329.BWG_0533,iE2348C_1286.E2348C_0555,iECBD_1354.ECBD_0830,iECB_1328.ECB_02739,iECDH10B_1368.ECDH10B_0731,iECDH1ME8569_1439.ECDH1ME8569_0631,iECD_1391.ECD_02739,iETEC_1333.ETEC_0690,iEcDH1_1363.EcDH1_2964,iEcHS_1320.EcHS_A0709,iEcHS_1320.EcHS_A3066,iJO1366.b0662,iJR904.b0662,iSBO_1134.SBO_0526,iSbBS512_1146.SbBS512_E0585,iUMNK88_1353.UMNK88_700,iY75_1357.Y75_RS03450	Bacteria	1MU6I@1224,1RND5@1236,3XM7R@561,COG0654@1,COG0654@2	NA|NA|NA	CH	2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity
C1_02542	155864.EDL933_0739	7.7e-274	949.1	Escherichia	miaB	GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035597,GO:0035600,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360	2.8.4.3	ko:K06168			R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016				Bacteria	1MURS@1224,1RMD8@1236,3XP7C@561,COG0621@1,COG0621@2	NA|NA|NA	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C1_02543	198214.SF0622	3.1e-198	697.6	Gammaproteobacteria	ybeZ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K06217					ko00000				Bacteria	1MVDV@1224,1RP2Y@1236,COG1702@1,COG1702@2	NA|NA|NA	T	phosphate starvation-inducible protein PhoH
C1_02544	198214.SF0623	1.6e-82	312.0	Gammaproteobacteria	ybeY	GO:0000469,GO:0000478,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0006139,GO:0006355,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016072,GO:0016151,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0019219,GO:0019222,GO:0019538,GO:0022613,GO:0030490,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043244,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141	2.6.99.2,3.5.4.5	ko:K01489,ko:K03474,ko:K03595,ko:K07042	ko00240,ko00750,ko00983,ko01100,map00240,map00750,map00983,map01100	M00124	R01878,R02485,R05838,R08221	RC00074,RC00514,RC01476	ko00000,ko00001,ko00002,ko01000,ko03009,ko03029				Bacteria	1MZ67@1224,1S6BS@1236,COG0319@1,COG0319@2	NA|NA|NA	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C1_02545	155864.EDL933_0735	3.5e-160	570.9	Escherichia	corC	GO:0001897,GO:0001906,GO:0001907,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009405,GO:0009987,GO:0016020,GO:0019835,GO:0019836,GO:0031640,GO:0035821,GO:0044003,GO:0044004,GO:0044179,GO:0044364,GO:0044403,GO:0044419,GO:0044464,GO:0044764,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0071944		ko:K06189					ko00000,ko02000	9.A.40.1.2			Bacteria	1QTU8@1224,1RMKX@1236,3XN7E@561,COG4535@1,COG4535@2	NA|NA|NA	P	Magnesium and cobalt efflux protein CorC
C1_02546	199310.c0742	3.8e-295	1020.0	Escherichia	lnt	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016021,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576		ko:K03820					ko00000,ko01000		GT2	iEcSMS35_1347.EcSMS35_0678,iSbBS512_1146.SbBS512_E0590	Bacteria	1MUBU@1224,1RM8M@1236,3XNIF@561,COG0815@1,COG0815@2	NA|NA|NA	M	Transfers the fatty acyl group on membrane lipoproteins
C1_02547	481805.EcolC_2989	0.0	1157.5	Gammaproteobacteria	aarA		3.4.21.105	ko:K19225					ko00000,ko01000,ko01002				Bacteria	1N1S0@1224,1SD36@1236,COG0705@1,COG0705@2,COG3391@1,COG3391@2	NA|NA|NA	S	membrane protein (homolog of Drosophila rhomboid)
C1_02548	155864.EDL933_0732	3.6e-168	597.4	Escherichia	gltI	GO:0003333,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0015711,GO:0015740,GO:0015800,GO:0015807,GO:0015813,GO:0015849,GO:0015893,GO:0016595,GO:0016597,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0034220,GO:0036094,GO:0042221,GO:0042493,GO:0042597,GO:0043167,GO:0043168,GO:0043177,GO:0044464,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070335,GO:0070778,GO:0071702,GO:0071705,GO:0098656,GO:1902475,GO:1903825,GO:1905039		ko:K10001	ko02010,ko02020,map02010,map02020	M00230			ko00000,ko00001,ko00002,ko02000	3.A.1.3.19,3.A.1.3.4		iECH74115_1262.ECH74115_0748,iECSE_1348.ECSE_0725,iECSP_1301.ECSP_0707,iECW_1372.ECW_m0710,iECs_1301.ECs0694,iEKO11_1354.EKO11_3211,iG2583_1286.G2583_0819,iSFV_1184.SFV_0671,iSF_1195.SF0626,iS_1188.S0648,iWFL_1372.ECW_m0710,iZ_1308.Z0805	Bacteria	1MV5D@1224,1RPBX@1236,3XM2X@561,COG0834@1,COG0834@2	NA|NA|NA	ET	Part of the ABC transporter complex GltIJKL involved in glutamate and aspartate uptake. Binds to both glutamate and aspartate
C1_02549	1440052.EAKF1_ch0799	6.9e-133	479.9	Escherichia	gltJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02029,ko:K10003,ko:K10040	ko02010,ko02020,map02010,map02020	M00228,M00230,M00236			ko00000,ko00001,ko00002,ko02000	3.A.1.3,3.A.1.3.19,3.A.1.3.4		iJN746.PP_1070	Bacteria	1MUVX@1224,1RMTK@1236,3XN5Z@561,COG0765@1,COG0765@2	NA|NA|NA	P	Part of the ABC transporter complex GltIJKL involved in glutamate and aspartate uptake. Probably responsible for the translocation of the substrate across the membrane
C1_02550	155864.EDL933_0730	1.9e-113	415.2	Escherichia	gltK	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015318,GO:0015711,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:1901998,GO:1903825,GO:1905039		ko:K02029,ko:K10002	ko02010,ko02020,map02010,map02020	M00230,M00236			ko00000,ko00001,ko00002,ko02000	3.A.1.3,3.A.1.3.19,3.A.1.3.4		iEcHS_1320.EcHS_A0698,iEcolC_1368.EcolC_2992,iSF_1195.SF0628,iSFxv_1172.SFxv_0695,iS_1188.S0650	Bacteria	1MV3I@1224,1RNX3@1236,3XN5D@561,COG0765@1,COG0765@2	NA|NA|NA	E	Part of the ABC transporter complex GltIJKL involved in glutamate and aspartate uptake. Probably responsible for the translocation of the substrate across the membrane
C1_02551	155864.EDL933_0729	2.7e-129	468.0	Escherichia	gltL	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	3.6.3.21	ko:K02028,ko:K09972,ko:K10004	ko02010,ko02020,map02010,map02020	M00230,M00232,M00236			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3,3.A.1.3.17,3.A.1.3.18,3.A.1.3.19,3.A.1.3.4,3.A.1.3.7,3.A.1.3.8		iAPECO1_1312.APECO1_1411,iE2348C_1286.E2348C_0545,iECOK1_1307.ECOK1_0655,iECP_1309.ECP_0675,iECS88_1305.ECS88_0687,iEcSMS35_1347.EcSMS35_0673,iUMN146_1321.UM146_14290,iUTI89_1310.UTI89_C0648	Bacteria	1MU9Q@1224,1RMX1@1236,3XPF4@561,COG1126@1,COG1126@2	NA|NA|NA	P	Part of the ABC transporter complex GltIJKL involved in glutamate and aspartate uptake. Probably responsible for energy coupling to the transport system
C1_02552	316407.4062271	2.6e-177	627.9	Escherichia	rihA	GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006152,GO:0006213,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008477,GO:0009056,GO:0009116,GO:0009119,GO:0009164,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019439,GO:0033554,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042454,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0045437,GO:0046131,GO:0046133,GO:0046135,GO:0046483,GO:0046700,GO:0046872,GO:0047405,GO:0047622,GO:0047724,GO:0050263,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658	3.2.2.8	ko:K01250,ko:K10213,ko:K12700	ko00230,ko00240,ko01100,map00230,map00240,map01100		R01245,R01677,R01770,R02137	RC00063,RC00318	ko00000,ko00001,ko01000			iEC55989_1330.EC55989_0645,iECH74115_1262.ECH74115_3298,iECSE_1348.ECSE_0721,iECSP_1301.ECSP_3040,iECs_1301.ECs3054,iEcE24377_1341.EcE24377A_0030,iEcE24377_1341.EcE24377A_0679,iSbBS512_1146.SbBS512_E0598,iZ_1308.Z3419	Bacteria	1MUIW@1224,1RSCY@1236,3XN0M@561,COG1957@1,COG1957@2	NA|NA|NA	F	Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively
C1_02553	316407.85674731	0.0	1083.2	Escherichia	hscC	GO:0003674,GO:0003824,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111		ko:K04045					ko00000,ko03110	1.A.33		iECO26_1355.ECO26_0725,iSFV_1184.SFV_0676	Bacteria	1MUR1@1224,1RR7P@1236,3XM93@561,COG0443@1,COG0443@2	NA|NA|NA	O	heat shock protein 70
C1_02554	316407.4062264	6.9e-278	962.6	Escherichia	djlC	GO:0001671,GO:0003674,GO:0008047,GO:0008150,GO:0030234,GO:0032781,GO:0043085,GO:0043462,GO:0044093,GO:0050790,GO:0051336,GO:0051345,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0098772											Bacteria	1ND28@1224,1SYVJ@1236,3XM84@561,COG2214@1,COG2214@2	NA|NA|NA	O	ATPase activator activity
C1_02555	316407.4062263	7.8e-134	483.0	Escherichia	ybeU												Bacteria	1RCBR@1224,1S2HD@1236,2DBZ5@1,2ZBZM@2,3XQJF@561	NA|NA|NA	S	Protein of unknown function (DUF1266)
C1_02556	316407.4062262	3.5e-65	254.6	Escherichia	ybeT	GO:0003674,GO:0006950,GO:0006979,GO:0008047,GO:0008150,GO:0030234,GO:0043085,GO:0044093,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0098772		ko:K07126					ko00000				Bacteria	1PE8S@1224,1RW8B@1236,3XPKY@561,COG0790@1,COG0790@2	NA|NA|NA	S	Sel1-like repeats.
C1_02557	155864.EDL933_0721	3.9e-204	717.2	Gammaproteobacteria	djlB												Bacteria	1ND28@1224,1RYBT@1236,COG2214@1,COG2214@2	NA|NA|NA	O	PFAM heat shock protein DnaJ domain protein
C1_02558	198214.SF0635	3.8e-22	110.2	Gammaproteobacteria	djlB												Bacteria	1ND28@1224,1RYBT@1236,COG2214@1,COG2214@2	NA|NA|NA	O	PFAM heat shock protein DnaJ domain protein
C1_02559	316407.4062260	1.2e-134	485.7	Gammaproteobacteria	ybeR												Bacteria	1R3BD@1224,1SIT7@1236,2DTDZ@1,33JXN@2	NA|NA|NA	S	Protein of unknown function (DUF1266)
C1_02560	316407.85674730	3.3e-42	179.1	Gammaproteobacteria	ybeQ	GO:0003674,GO:0006950,GO:0006979,GO:0008047,GO:0008150,GO:0030234,GO:0043085,GO:0044093,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0098772		ko:K07126					ko00000				Bacteria	1MWPA@1224,1RPI3@1236,COG0790@1,COG0790@2	NA|NA|NA	O	COG0790 FOG TPR repeat, SEL1 subfamily
C1_02561	155864.EDL933_0717	3.5e-85	320.9	Escherichia	ybeL		1.17.4.1,4.6.1.1	ko:K00525,ko:K01768	ko00230,ko00240,ko01100,ko02025,ko04113,ko04213,map00230,map00240,map01100,map02025,map04113,map04213	M00053,M00695	R00089,R00434,R02017,R02018,R02019,R02024	RC00295,RC00613	ko00000,ko00001,ko00002,ko01000,ko03400				Bacteria	1P9T7@1224,1RYIB@1236,3XMF4@561,COG2888@1,COG2888@2	NA|NA|NA	J	Zinc-ribbon containing domain
C1_02562	199310.c0733	0.0	1764.2	Escherichia	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029			iECOK1_1307.ECOK1_0652,iECS88_1305.ECS88_0684,iNRG857_1313.NRG857_02925,iPC815.YPO2610	Bacteria	1MV47@1224,1RP14@1236,3XMA7@561,COG0495@1,COG0495@2	NA|NA|NA	J	Belongs to the class-I aminoacyl-tRNA synthetase family
C1_02563	199310.c0732	1.6e-100	372.1	Escherichia	lptE	GO:0001530,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0008289,GO:0009279,GO:0009987,GO:0010876,GO:0015920,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044462,GO:0044464,GO:0045229,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071709,GO:0071840,GO:0071944,GO:0097367,GO:1901264		ko:K03643					ko00000,ko02000	1.B.42.1		iECH74115_1262.ECH74115_0730,iECSP_1301.ECSP_0694,iECs_1301.ECs0679,iG2583_1286.G2583_0804,iZ_1308.Z0788	Bacteria	1N0JN@1224,1SAG4@1236,3XMTH@561,COG2980@1,COG2980@2	NA|NA|NA	M	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
C1_02564	198214.SF0641	1.5e-189	668.7	Gammaproteobacteria	holA	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Bacteria	1MWYT@1224,1RQRE@1236,COG1466@1,COG1466@2	NA|NA|NA	L	dna polymerase III delta subunit
C1_02565	198214.SF0642	6.6e-124	449.9	Gammaproteobacteria	nadD	GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034355,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043094,GO:0043173,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.7.18,3.5.4.4,3.6.1.55	ko:K00969,ko:K01488,ko:K03574	ko00230,ko00760,ko01100,ko05340,map00230,map00760,map01100,map05340	M00115	R00137,R01560,R02556,R03005	RC00002,RC00477	ko00000,ko00001,ko00002,ko01000,ko03400			iECUMN_1333.ECUMN_0733,iJN746.PP_4810,iPC815.YPO2607,iSbBS512_1146.SbBS512_E0612	Bacteria	1RD0J@1224,1RP00@1236,COG1057@1,COG1057@2	NA|NA|NA	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C1_02566	316407.4062256	1.8e-115	421.8	Escherichia	cobC		3.1.3.73	ko:K02226	ko00860,ko01100,map00860,map01100	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_1417,iEcSMS35_1347.EcSMS35_0658,iLF82_1304.LF82_0334,iUTI89_1310.UTI89_C0641,ic_1306.c0729	Bacteria	1RHAT@1224,1S2NY@1236,3XN3N@561,COG0406@1,COG0406@2	NA|NA|NA	G	Belongs to the phosphoglycerate mutase family
C1_02567	1440052.EAKF1_ch0824	9.7e-52	209.1	Escherichia	rsfS	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090071,GO:2000112,GO:2000113	2.7.7.18	ko:K00969,ko:K09710	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000,ko03009				Bacteria	1MZEF@1224,1S8W3@1236,3XPWB@561,COG0799@1,COG0799@2	NA|NA|NA	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
C1_02568	1440052.EAKF1_ch0825	5.7e-85	320.1	Escherichia	rlmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042802,GO:0042803,GO:0043021,GO:0043022,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0044877,GO:0046483,GO:0046983,GO:0070037,GO:0070038,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.177	ko:K00783					ko00000,ko01000,ko03009				Bacteria	1R9Z2@1224,1S1ZY@1236,3XNYW@561,COG1576@1,COG1576@2	NA|NA|NA	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C1_02569	155864.EDL933_0709	0.0	1284.6	Escherichia	mrdA	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501				ko00000,ko00001,ko01000,ko01011			iAF987.Gmet_0928,iEcE24377_1341.EcE24377A_0661,iPC815.YPO2604	Bacteria	1MV8C@1224,1RN9H@1236,3XNHA@561,COG0768@1,COG0768@2	NA|NA|NA	M	Catalyzes cross-linking of the peptidoglycan cell wall
C1_02570	155864.EDL933_0708	1.2e-197	695.7	Escherichia	mrdB	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008360,GO:0016020,GO:0022603,GO:0022604,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944		ko:K05837					ko00000,ko03036				Bacteria	1MUK3@1224,1RMEJ@1236,3XNZ0@561,COG0772@1,COG0772@2	NA|NA|NA	M	Peptidoglycan polymerase that is essential for cell wall elongation
C1_02571	316407.1651260	3.7e-191	674.1	Escherichia	rlpA	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944		ko:K03642					ko00000				Bacteria	1MZ8S@1224,1RMCG@1236,3XP5D@561,COG0797@1,COG0797@2	NA|NA|NA	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C1_02572	155864.EDL933_0705	2.9e-229	800.8	Escherichia	dacA	GO:0000270,GO:0003674,GO:0003824,GO:0004175,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044237,GO:0044238,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0071554,GO:0071704,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901363,GO:1901564,GO:1901681	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100				ko00000,ko00001,ko01000,ko01002,ko01011			iEC55989_1330.EC55989_2269,iSFV_1184.SFV_0694,iSbBS512_1146.SbBS512_E2506,iYL1228.KPN_00664	Bacteria	1MUU7@1224,1RMJA@1236,3XM3R@561,COG1686@1,COG1686@2	NA|NA|NA	M	Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors
C1_02573	1440052.EAKF1_ch0831	2.2e-41	174.5	Escherichia	ybeD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K09158					ko00000				Bacteria	1RGV5@1224,1S61Y@1236,3XPY6@561,COG2921@1,COG2921@2	NA|NA|NA	S	Belongs to the UPF0250 family
C1_02574	155864.EDL933_0703	1.3e-119	435.6	Escherichia	lipB	GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0016874,GO:0016879,GO:0016979,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019222,GO:0019538,GO:0019752,GO:0032787,GO:0033819,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048519,GO:0050789,GO:0051186,GO:0051188,GO:0051604,GO:0060255,GO:0065007,GO:0071704,GO:0072330,GO:0140096,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100		R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000			iECSF_1327.ECSF_0569,iSFV_1184.SFV_0696,iSFxv_1172.SFxv_0718	Bacteria	1MU6A@1224,1RMXQ@1236,3XM74@561,COG0321@1,COG0321@2	NA|NA|NA	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate
C1_02575	316407.4062251	5.9e-177	626.7	Escherichia	ybeF	GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141											Bacteria	1Q6Q3@1224,1RV8G@1236,3XNG9@561,COG0583@1,COG0583@2	NA|NA|NA	K	DNA-binding transcription factor activity
C1_02576	155864.EDL933_0700	5.4e-186	656.8	Escherichia	lipA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100		R07767,R07768	RC01978	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_1427,iB21_1397.B21_00586,iBWG_1329.BWG_0499,iE2348C_1286.E2348C_0528,iEC55989_1330.EC55989_0620,iECABU_c1320.ECABU_c06820,iECBD_1354.ECBD_3023,iECB_1328.ECB_00597,iECDH10B_1368.ECDH10B_0589,iECDH1ME8569_1439.ECDH1ME8569_0597,iECD_1391.ECD_00597,iECED1_1282.ECED1_0624,iECH74115_1262.ECH74115_0716,iECIAI1_1343.ECIAI1_0611,iECIAI39_1322.ECIAI39_0603,iECNA114_1301.ECNA114_0567,iECO103_1326.ECO103_0635,iECO111_1330.ECO111_0658,iECO26_1355.ECO26_0702,iECOK1_1307.ECOK1_0638,iECP_1309.ECP_0658,iECS88_1305.ECS88_0669,iECSE_1348.ECSE_0695,iECSF_1327.ECSF_0567,iECSP_1301.ECSP_0681,iECUMN_1333.ECUMN_0720,iECW_1372.ECW_m0682,iECs_1301.ECs0666,iEKO11_1354.EKO11_3238,iETEC_1333.ETEC_0656,iEcDH1_1363.EcDH1_2998,iEcE24377_1341.EcE24377A_0652,iEcHS_1320.EcHS_A0679,iEcSMS35_1347.EcSMS35_0648,iEcolC_1368.EcolC_3017,iG2583_1286.G2583_0791,iJO1366.b0628,iLF82_1304.LF82_1199,iNRG857_1313.NRG857_02855,iSBO_1134.SBO_0492,iSDY_1059.SDY_0550,iSF_1195.SF0653,iSFxv_1172.SFxv_0720,iSSON_1240.SSON_0582,iS_1188.S0675,iSbBS512_1146.SbBS512_E0542,iUMN146_1321.UM146_14375,iUMNK88_1353.UMNK88_663,iUTI89_1310.UTI89_C0631,iWFL_1372.ECW_m0682,iY75_1357.Y75_RS03275,ic_1306.c0718	Bacteria	1MVRD@1224,1RMAT@1236,3XP60@561,COG0320@1,COG0320@2	NA|NA|NA	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C1_02577	155864.EDL933_0699	7.6e-26	122.5	Escherichia	tatE	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033281,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0098796,GO:0098797		ko:K03116,ko:K03425	ko03060,ko03070,map03060,map03070	M00336			ko00000,ko00001,ko00002,ko02044	2.A.64			Bacteria	1N7JK@1224,1SCGF@1236,3XQ43@561,COG1826@1,COG1826@2	NA|NA|NA	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA
C1_02578	155864.EDL933_0698	3.5e-143	514.2	Escherichia	ybeM		3.5.1.3	ko:K11206,ko:K13566	ko00250,map00250		R00269,R00348	RC00010	ko00000,ko00001,ko01000				Bacteria	1MUUB@1224,1RNVZ@1236,3XMHF@561,COG0388@1,COG0388@2	NA|NA|NA	S	terminal fragment. The intact protein (AC A0A140NCB4) hydrolyzes deaminated glutathione (dGSH, 2-oxoglutaramate) to alpha- ketoglutarate (alpha-KG) and cysteinylglycine, has less activity against alpha-ketoglutaramate (a-KGM) and no activity on glutathione or L-glutamine (By similarity). May function as a metabolite repair enzyme (By similarity)
C1_02579	155864.EDL933_0697	2.9e-66	257.7	Escherichia	crcB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425		ko:K06199					ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3			Bacteria	1MZNH@1224,1S9GR@1236,3XPQE@561,COG0239@1,COG0239@2	NA|NA|NA	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C1_02580	1197719.A464_605	3.3e-32	143.7	Salmonella	cspE	GO:0001072,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003723,GO:0003727,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006950,GO:0008143,GO:0008150,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031554,GO:0031564,GO:0043242,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0060567,GO:0065007,GO:0070717,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K03704					ko00000,ko03000			iECW_1372.ECW_m0678,iWFL_1372.ECW_m0678	Bacteria	1N6Q5@1224,1SCA7@1236,3ZMIG@590,COG1278@1,COG1278@2	NA|NA|NA	K	Ribonuclease B OB domain
C1_02581	316407.85674727	1.6e-110	405.2	Escherichia	pagP	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009279,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016409,GO:0016416,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044462,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.3.1.251	ko:K12973	ko01503,ko05133,map01503,map05133	M00724	R11223	RC00037,RC00041	ko00000,ko00001,ko00002,ko01000,ko01005			iEC042_1314.EC042_0658,iECO111_1330.ECO111_0653,iECSE_1348.ECSE_0690,iEcolC_1368.EcolC_3022	Bacteria	1Q75P@1224,1RPCR@1236,2C256@1,2Z7SY@2,3XPJP@561	NA|NA|NA	M	Transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors
C1_02582	155864.EDL933_0694	1.3e-236	825.5	Escherichia	dcuC	GO:0003674,GO:0005215,GO:0005310,GO:0005342,GO:0005469,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006067,GO:0006082,GO:0006083,GO:0006089,GO:0006090,GO:0006091,GO:0006103,GO:0006105,GO:0006113,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006855,GO:0008150,GO:0008152,GO:0008509,GO:0008514,GO:0009117,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009179,GO:0009185,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015075,GO:0015138,GO:0015141,GO:0015238,GO:0015291,GO:0015297,GO:0015318,GO:0015556,GO:0015711,GO:0015740,GO:0015741,GO:0015744,GO:0015849,GO:0015893,GO:0015942,GO:0015980,GO:0016020,GO:0016021,GO:0016999,GO:0017144,GO:0019318,GO:0019362,GO:0019637,GO:0019660,GO:0019664,GO:0019666,GO:0019693,GO:0019752,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0032787,GO:0034220,GO:0034308,GO:0034641,GO:0042221,GO:0042493,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0046031,GO:0046034,GO:0046483,GO:0046496,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051186,GO:0051234,GO:0055085,GO:0055086,GO:0055114,GO:0071422,GO:0071702,GO:0071704,GO:0071944,GO:0072521,GO:0072524,GO:0098656,GO:1901135,GO:1901360,GO:1901564,GO:1901615,GO:1903825,GO:1905039		ko:K03326					ko00000,ko02000	2.A.61.1			Bacteria	1MWBG@1224,1RQB2@1236,3XNN1@561,COG3069@1,COG3069@2	NA|NA|NA	P	Responsible for the transport of C4-dicarboxylates during anaerobic growth
C1_02583	199310.c0711	1.4e-124	452.2	Escherichia	dpiA	GO:0000156,GO:0000160,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0023052,GO:0031323,GO:0031326,GO:0035556,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051716,GO:0060089,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141		ko:K02475,ko:K07702,ko:K07703	ko02020,map02020	M00486,M00488			ko00000,ko00001,ko00002,ko02022				Bacteria	1P6VJ@1224,1RPI7@1236,3XPEN@561,COG4565@1,COG4565@2	NA|NA|NA	K	Member of the two-component regulatory system DpiA DpiB, which is essential for expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. Could be involved in response to both the presence of citrate and external redox conditions
C1_02584	316407.4062236	5e-309	1066.2	Escherichia	dpiB	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009889,GO:0009987,GO:0010033,GO:0010468,GO:0010556,GO:0016020,GO:0016021,GO:0016043,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019219,GO:0019222,GO:0019538,GO:0022607,GO:0023014,GO:0023052,GO:0031224,GO:0031226,GO:0031323,GO:0031326,GO:0035556,GO:0036211,GO:0042221,GO:0042802,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051259,GO:0051260,GO:0051716,GO:0060255,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0140096,GO:1901564,GO:1903506,GO:2000112,GO:2001141	2.7.13.3	ko:K02476,ko:K07700,ko:K07701,ko:K11614	ko02020,map02020	M00486,M00488,M00490			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	1MXQ5@1224,1RNRF@1236,3XPGZ@561,COG3290@1,COG3290@2	NA|NA|NA	T	Member of the two-component regulatory system DpiA DpiB, which is essential for expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. Could be involved in response to both the presence of citrate and external redox conditions. Functions as a sensor kinase that phosphorylates DpiA in the presence of citrate
C1_02585	316407.85674725	1.9e-200	704.9	Escherichia	citC	GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008771,GO:0009987,GO:0016874,GO:0016877,GO:0016878,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564	6.2.1.22	ko:K01910	ko02020,map02020		R04449	RC00012,RC00039	ko00000,ko00001,ko01000				Bacteria	1NGEJ@1224,1RMMV@1236,3XNVE@561,COG3053@1,COG3053@2	NA|NA|NA	H	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
C1_02586	155864.EDL933_0690	1.8e-47	194.9	Escherichia	citD	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464,GO:0048037,GO:0051192		ko:K01646	ko02020,map02020		R00362	RC00067,RC01118	ko00000,ko00001			iECABU_c1320.ECABU_c06690,iECED1_1282.ECED1_0614	Bacteria	1N20F@1224,1S98D@1236,3XPVK@561,COG3052@1,COG3052@2	NA|NA|NA	C	Covalent carrier of the coenzyme of citrate lyase
C1_02587	199310.c0706	1.7e-162	578.6	Escherichia	citE	GO:0000287,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006107,GO:0008150,GO:0008152,GO:0009987,GO:0019752,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0046872,GO:0071704	4.1.3.25,4.1.3.34	ko:K01644,ko:K18292	ko00660,ko01100,ko02020,map00660,map01100,map02020		R00237,R00362	RC00067,RC00502,RC01118,RC01205	ko00000,ko00001,ko01000			iHN637.CLJU_RS12480,iSFxv_1172.SFxv_0589	Bacteria	1MW0A@1224,1RNEJ@1236,3XNE8@561,COG2301@1,COG2301@2	NA|NA|NA	G	Belongs to the HpcH HpaI aldolase family
C1_02588	469008.B21_00572	2.9e-287	993.8	Escherichia	citF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.8.3.10	ko:K01643	ko02020,map02020		R00362	RC00067,RC01118	ko00000,ko00001,ko01000			iEcSMS35_1347.EcSMS35_0634	Bacteria	1MYI9@1224,1RQ32@1236,3XNRW@561,COG3051@1,COG3051@2	NA|NA|NA	C	Citrate (pro-3S)-lyase alpha chain
C1_02589	155864.EDL933_0687	7.5e-100	369.8	Escherichia	citX	GO:0003674,GO:0003824,GO:0006091,GO:0006113,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0015980,GO:0016740,GO:0016772,GO:0016779,GO:0016780,GO:0018065,GO:0018193,GO:0018209,GO:0018246,GO:0018247,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046917,GO:0050519,GO:0051186,GO:0051188,GO:0051189,GO:0051191,GO:0055114,GO:0071704,GO:1901564,GO:1901576	2.4.2.52,2.7.7.61	ko:K05964,ko:K13927	ko02020,map02020		R09675,R10706	RC00049,RC00063	ko00000,ko00001,ko01000			iEcHS_1320.EcHS_A0665,iEcolC_1368.EcolC_3030	Bacteria	1RDJS@1224,1S4KU@1236,3XMCM@561,COG3697@1,COG3697@2	NA|NA|NA	H	Transfers 2-(5''-triphosphoribosyl)-3'- dephosphocoenzyme-A on a serine residue to the apo-acyl carrier protein (gamma chain) of the citrate lyase to yield holo-acyl carrier protein
C1_02590	316407.85674722	6.2e-165	586.6	Escherichia	citG	GO:0003674,GO:0003824,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0019538,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046917,GO:0051186,GO:0051188,GO:0051189,GO:0051191,GO:0071704,GO:1901564,GO:1901576	2.4.2.52,2.7.7.61	ko:K05966,ko:K13927,ko:K13930	ko02020,map02020		R09675,R10706	RC00049,RC00063	ko00000,ko00001,ko01000			iECSF_1327.ECSF_0553	Bacteria	1N9IK@1224,1RYW6@1236,3XNS3@561,COG1767@1,COG1767@2	NA|NA|NA	F	Catalyzes the formation of 2-(5''-triphosphoribosyl)-3'- dephosphocoenzyme-A, the precursor of the prosthetic group of the holo-acyl carrier protein (gamma chain) of citrate lyase, from ATP and dephospho-CoA
C1_02591	316407.4062225	7.2e-275	952.6	Escherichia	citT	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0015291,GO:0015297,GO:0016020,GO:0022804,GO:0022857,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944		ko:K03319,ko:K09477,ko:K11106	ko02020,map02020				ko00000,ko00001,ko02000	2.A.47,2.A.47.3.2,2.A.47.3.3		iAF1260.b3063,iBWG_1329.BWG_2774,iECDH10B_1368.ECDH10B_3238,iECDH1ME8569_1439.ECDH1ME8569_2959,iECIAI1_1343.ECIAI1_3211,iETEC_1333.ETEC_3334,iEcDH1_1363.EcDH1_0637,iEcolC_1368.EcolC_0636,iJO1366.b3063,iJR904.b3063,iSSON_1240.SSON_0564,iUMNK88_1353.UMNK88_3815,iY75_1357.Y75_RS15915	Bacteria	1MUSA@1224,1RMF3@1236,3XM3A@561,COG0471@1,COG0471@2	NA|NA|NA	P	Responsible for the uptake of citrate in exchange with the efflux of succinate, fumarate or tartrate. Has a relatively broad specificity for C(4)-dicarboxylates and tricarboxylates
C1_02592	316407.1651249	3.1e-155	554.3	Escherichia	rna	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0019439,GO:0030288,GO:0030313,GO:0031975,GO:0034641,GO:0034655,GO:0042597,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575	3.1.27.1,3.1.27.6	ko:K01166,ko:K01169					ko00000,ko01000,ko03016				Bacteria	1NRPM@1224,1RND8@1236,3XMFW@561,COG3719@1,COG3719@2	NA|NA|NA	J	Belongs to the RNase T2 family
C1_02593	155864.EDL933_0683	1.9e-71	275.0	Escherichia	rnk			ko:K03624,ko:K06140					ko00000,ko03000,ko03021				Bacteria	1MZNY@1224,1S8V4@1236,3XPJU@561,COG0782@1,COG0782@2	NA|NA|NA	K	May act as an anti-Gre factor
C1_02595	155864.EDL933_0681	1.2e-238	832.0	Escherichia	ybdR		1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000				Bacteria	1MW6Y@1224,1RRPT@1236,3XP75@561,COG1063@1,COG1063@2	NA|NA|NA	E	zinc ion binding
C1_02596	316407.4062223	1.1e-71	275.8	Escherichia	uspG	GO:0000166,GO:0003674,GO:0003824,GO:0004017,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006464,GO:0006468,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0007155,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018117,GO:0018130,GO:0018175,GO:0019205,GO:0019438,GO:0019538,GO:0019637,GO:0022610,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032879,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0036211,GO:0040012,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046777,GO:0046940,GO:0050145,GO:0050789,GO:0050794,GO:0050896,GO:0051270,GO:0055086,GO:0065007,GO:0071704,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901576,GO:2000145		ko:K11932,ko:K14061					ko00000				Bacteria	1RA7K@1224,1S2PE@1236,3XPN8@561,COG0589@1,COG0589@2	NA|NA|NA	T	Belongs to the universal stress protein A family
C1_02597	155864.EDL933_0678	5.8e-302	1042.7	Escherichia	ahpF	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008785,GO:0009321,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071949,GO:0097159,GO:1901265,GO:1901363,GO:1902494,GO:1990204		ko:K03387					ko00000,ko01000				Bacteria	1MUKD@1224,1RNC7@1236,3XPHP@561,COG3634@1,COG3634@2	NA|NA|NA	O	Alkyl hydroperoxide reductase
C1_02598	155864.EDL933_0677	1.5e-103	382.1	Escherichia	ahpC	GO:0003674,GO:0003824,GO:0004601,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009321,GO:0009605,GO:0009636,GO:0009970,GO:0009987,GO:0009991,GO:0010033,GO:0016209,GO:0016491,GO:0016667,GO:0016671,GO:0016684,GO:0019725,GO:0030003,GO:0031667,GO:0031668,GO:0031669,GO:0032843,GO:0032991,GO:0033194,GO:0033195,GO:0033212,GO:0033214,GO:0033554,GO:0042221,GO:0042592,GO:0042594,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071496,GO:0097237,GO:0098754,GO:0098771,GO:0098869,GO:1901700,GO:1902494,GO:1990204,GO:1990748	1.11.1.15	ko:K03386	ko04214,map04214				ko00000,ko00001,ko01000,ko04147				Bacteria	1MWPY@1224,1RN4S@1236,3XM46@561,COG0450@1,COG0450@2	NA|NA|NA	O	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C1_02599	155864.EDL933_0676	1.9e-138	498.4	Escherichia	dsbG	GO:0003674,GO:0003756,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0042597,GO:0044464,GO:0055114,GO:0140096	5.3.4.1	ko:K03805,ko:K03981					ko00000,ko01000,ko02044,ko03110	3.A.7.11.1		iEC042_1314.EC042_3104,iECO111_1330.ECO111_0636,iECO26_1355.ECO26_0680,iEcE24377_1341.EcE24377A_0625,iG2583_1286.G2583_0768	Bacteria	1NEFD@1224,1RQAW@1236,3XNA2@561,COG1651@1,COG1651@2	NA|NA|NA	O	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C1_02600	316407.4062220	4.3e-161	573.9	Escherichia	ybdO	GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141											Bacteria	1QD8R@1224,1RSHD@1236,3XNPV@561,COG0583@1,COG0583@2	NA|NA|NA	K	Transcriptional regulator
C1_02601	155864.EDL933_0674	2.9e-253	880.6	Escherichia	ybdN												Bacteria	1NBDM@1224,1RYRP@1236,3XNM6@561,COG3969@1,COG3969@2	NA|NA|NA	S	catalytic activity
C1_02602	199310.c0689	5.5e-115	420.2	Escherichia	ibrB			ko:K03497					ko00000,ko03000,ko03036,ko04812				Bacteria	1R5VN@1224,1RZ7C@1236,3XNY5@561,COG1475@1,COG1475@2	NA|NA|NA	K	ParB-like nuclease domain
C1_02603	198214.SF0515	2.8e-221	774.2	Gammaproteobacteria	ybdL	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0008144,GO:0008483,GO:0010326,GO:0016740,GO:0016769,GO:0019842,GO:0030170,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0071944,GO:0097159,GO:1901363	2.6.1.17,2.6.1.88	ko:K14267,ko:K14287	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04475,R08618	RC00006,RC00025	ko00000,ko00001,ko00002,ko01000,ko01007			iNJ661.Rv0858c	Bacteria	1MW0Z@1224,1RNN0@1236,COG0436@1,COG0436@2	NA|NA|NA	E	aminotransferase
C1_02604	198214.SF0514	5.4e-203	713.4	Gammaproteobacteria	gldA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0042802,GO:0047545,GO:0055114	1.1.1.1,1.1.1.6	ko:K00001,ko:K00005,ko:K08317	ko00010,ko00071,ko00350,ko00561,ko00625,ko00626,ko00640,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00561,map00625,map00626,map00640,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220		R00623,R00754,R01034,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310,R10715,R10717	RC00029,RC00050,RC00087,RC00088,RC00099,RC00116,RC00117,RC00649,RC00670,RC01734,RC02273	ko00000,ko00001,ko01000			iJN678.gldA	Bacteria	1MWAE@1224,1RM83@1236,COG0371@1,COG0371@2	NA|NA|NA	C	Iron-containing alcohol dehydrogenase
C1_02605	155864.EDL933_0670	3.1e-32	143.7	Escherichia	ybdD												Bacteria	1N6TY@1224,1S8ZU@1236,3XPZM@561,COG2879@1,COG2879@2	NA|NA|NA	S	Selenoprotein, putative
C1_02606	316407.85674719	0.0	1327.4	Escherichia	cstA	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042594,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:0071944		ko:K06200					ko00000				Bacteria	1MWF9@1224,1RMG4@1236,3XM2Y@561,COG1966@1,COG1966@2	NA|NA|NA	T	carbon starvation protein
C1_02607	199310.c0684	1.6e-75	288.5	Escherichia	entH	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009237,GO:0009238,GO:0009239,GO:0009712,GO:0009713,GO:0009987,GO:0016289,GO:0016787,GO:0016788,GO:0016790,GO:0018130,GO:0018958,GO:0019184,GO:0019290,GO:0019438,GO:0019540,GO:0019748,GO:0034641,GO:0042802,GO:0043043,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0046189,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	3.1.2.28	ko:K19222	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R07262	RC00004,RC00174	ko00000,ko00001,ko00002,ko01000				Bacteria	1MYE0@1224,1S2CT@1236,3XPMR@561,COG2050@1,COG2050@2	NA|NA|NA	Q	Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules
C1_02608	469008.B21_00552	1.1e-133	482.6	Escherichia													Bacteria	1MUD2@1224,1RN5N@1236,3XMUU@561,COG1028@1,COG1028@2	NA|NA|NA	IQ	Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)-serine. Catalyzes the reversible NAD-dependent oxidation of the C3-hydroxyl group of 2,3-dihydro-2,3-dihydroxybenzoate (2,3-diDHB), producing the transient intermediate 2-hydroxy-3-oxo-4,6-cyclohexadiene-1- carboxylate, which undergoes rapid aromatization to the final product, 2,3-dihydroxybenzoate (2,3-DHB). Only the compounds with a C3-hydroxyl group such as methyl 2,3-dihydro-2,3- dihydroxybenzoate, methyl-3-hydroxy-1,4-cyclohexadiene-1- carboxylate, trans-3-hydroxy-2-cyclohexene-1-carboxylate, cis-3- hydroxy-4-cyclohexene-1-carboxylate, cis-3-hydroxycyclohexane-1- carboxylic acid are oxidized to the corresponding ketone products. The stereospecificity of the C3 allylic alcohol group oxidation is 3R in a 1R,3R dihydro substrate. It can also increase the DHB-AMP ligase activity of EntE by interaction EntE
C1_02609	155864.EDL933_0665	6.1e-165	586.6	Escherichia	entB	GO:0000287,GO:0003674,GO:0003824,GO:0004463,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008908,GO:0009058,GO:0009237,GO:0009238,GO:0009239,GO:0009712,GO:0009713,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0016787,GO:0016801,GO:0016803,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0018958,GO:0019184,GO:0019290,GO:0019438,GO:0019540,GO:0019748,GO:0019842,GO:0031177,GO:0033218,GO:0034641,GO:0036094,GO:0042802,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0046189,GO:0046483,GO:0046872,GO:0047527,GO:0048037,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072341,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	3.3.2.1,6.3.2.14	ko:K01252	ko01053,ko01110,ko01130,map01053,map01110,map01130		R03037,R07644	RC00162,RC00350,RC02148,RC03046	ko00000,ko00001,ko01000,ko01008			iSFV_1184.SFV_0543	Bacteria	1MW2U@1224,1RRZ8@1236,3XM33@561,COG1535@1,COG1535@2,COG3433@1,COG3433@2	NA|NA|NA	Q	Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)-serine. The serine trilactone serves as a scaffolding for the three catechol functionalities that provide hexadentate coordination for the tightly ligated iron(2 ) atoms. EntB is a bifunctional protein that serves as an isochorismate lyase and an aryl carrier protein (ArCP). Catalyzes the conversion of isochorismate to 2,3-dihydro-2,3- dihydroxybenzoate (2,3-diDHB), the precursor of 2,3- dihydroxybenzoate (DHB). In the enterobactin assembly, EntB functions as an aryl carrier protein phosphopantetheinylated near the C terminus by EntD to yield holo-EntB, which is then acylated by EntE with 2,3-dihydroxybenzoyl-AMP to form DHB-holo-EntB. Then this product will serve in the formation of the amide bond between 2,3-dihydroxybenzoate (DHB) and L-serine
C1_02610	469008.B21_00550	1.7e-309	1067.8	Escherichia	entE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008668,GO:0009058,GO:0009237,GO:0009238,GO:0009239,GO:0009712,GO:0009713,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0018958,GO:0019184,GO:0019290,GO:0019438,GO:0019540,GO:0019748,GO:0034641,GO:0043043,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0046189,GO:0046483,GO:0047527,GO:0051186,GO:0051188,GO:0070566,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	2.7.7.58,6.3.2.14	ko:K02363	ko01053,ko01110,ko01130,map01053,map01110,map01130		R07644	RC00162,RC03046	ko00000,ko00001,ko01000,ko01008			iSF_1195.SF0508,iSSON_1240.SSON_0545,iS_1188.S0514,iZ_1308.Z0736	Bacteria	1NSN8@1224,1RP8K@1236,3XMDK@561,COG1021@1,COG1021@2	NA|NA|NA	Q	Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)-serine. The serine trilactone serves as a scaffolding for the three catechol functionalities that provide hexadentate coordination for the tightly ligated iron(2 ) atoms. EntE proccesses via a two-step adenylation- ligation reaction (bi-uni-uni-bi ping-pong mechanism). First, it catalyzes the activation of the carboxylate group of 2,3- dihydroxy-benzoate (DHB), via a reversible ATP-dependent pyrophosphate exchange reactions to yield the acyladenylate intermediate 2,3-dihydroxybenzoyl-AMP. It can also transfer AMP to salicylate, 2,4-dihydroxybenzoate, gentisate and 2,3,4- trihydroxybenzoate. In the second step, DHB is transferred from 2,3-dihydroxybenzoyl-AMP onto the phosphopantetheinylated EntB (holo-EntB) to form DHB-holo-EntB. Then this product will serve in the formation of the amide bond between 2,3-dihydroxybenzoate (DHB) and L-serine
C1_02611	155864.EDL933_0663	1e-218	765.8	Escherichia	entC	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008909,GO:0009058,GO:0009237,GO:0009238,GO:0009239,GO:0009712,GO:0009713,GO:0009987,GO:0016853,GO:0016866,GO:0018130,GO:0018958,GO:0019184,GO:0019290,GO:0019438,GO:0019540,GO:0019748,GO:0034641,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044550,GO:0046189,GO:0046483,GO:0046872,GO:0050486,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	5.4.4.2	ko:K02361,ko:K02552	ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130	M00116	R01717	RC00588	ko00000,ko00001,ko00002,ko01000			iEC55989_1330.EC55989_0585,iECIAI1_1343.ECIAI1_0577,iECO103_1326.ECO103_0601,iECO111_1330.ECO111_0623,iECO26_1355.ECO26_0668,iECW_1372.ECW_m0648,iEKO11_1354.EKO11_3272,iEcE24377_1341.EcE24377A_0613,iSbBS512_1146.SbBS512_E0495,iUMNK88_1353.UMNK88_626,iWFL_1372.ECW_m0648	Bacteria	1MVB7@1224,1RRBX@1236,3XNJD@561,COG1169@1,COG1169@2	NA|NA|NA	HQ	Involved in the biosynthesis of the siderophore enterobactin (macrocyclic trimeric lactone of N-(2,3- dihydroxybenzoyl)-serine). Catalyzes the reversible conversion of chorismate to isochorismate
C1_02612	199310.c0679	1.1e-170	605.9	Escherichia	fepB	GO:0000041,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006826,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0015682,GO:0015685,GO:0015688,GO:0015711,GO:0015850,GO:0015891,GO:0030001,GO:0030288,GO:0030313,GO:0031975,GO:0033554,GO:0042597,GO:0042930,GO:0044464,GO:0050896,GO:0051179,GO:0051181,GO:0051234,GO:0051716,GO:0071702,GO:0072512,GO:1901678		ko:K02016	ko02010,map02010	M00240			ko00000,ko00001,ko00002,ko02000	3.A.1.14		iECNA114_1301.ECNA114_0535	Bacteria	1NPCN@1224,1RPS9@1236,3XNYB@561,COG4592@1,COG4592@2	NA|NA|NA	P	part of the binding-protein- dependent transport system for uptake of ferrienterobactin
C1_02613	469008.B21_00547	1.6e-219	768.5	Escherichia	entS	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0015688,GO:0015711,GO:0015850,GO:0015891,GO:0016020,GO:0033554,GO:0042221,GO:0042930,GO:0044464,GO:0046677,GO:0050896,GO:0051179,GO:0051181,GO:0051234,GO:0051716,GO:0071702,GO:0071944,GO:1901678		ko:K08225					ko00000,ko02000	2.A.1.38		iECABU_c1320.ECABU_c06410,iSBO_1134.SBO_0452	Bacteria	1MXZ3@1224,1RMY2@1236,3XN2P@561,COG0477@1,COG0477@2	NA|NA|NA	EGP	Exports the siderophore enterobactin out of the cell
C1_02614	469008.B21_00546	9e-168	596.3	Escherichia	fepD	GO:0000041,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006826,GO:0008150,GO:0015343,GO:0015620,GO:0015682,GO:0015685,GO:0015688,GO:0015711,GO:0015850,GO:0015891,GO:0016020,GO:0022857,GO:0030001,GO:0042930,GO:0044464,GO:0044718,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0072512,GO:1901678		ko:K02015	ko02010,map02010	M00240			ko00000,ko00001,ko00002,ko02000	3.A.1.14		iB21_1397.B21_04117,iEC042_1314.EC042_4777,iEC55989_1330.EC55989_4961,iEC55989_1330.EC55989_4962,iECABU_c1320.ECABU_c49000,iECBD_1354.ECBD_3750,iECB_1328.ECB_04154,iECD_1391.ECD_04154,iECED1_1282.ECED1_5153,iECH74115_1262.ECH74115_0675,iECIAI39_1322.ECIAI39_4767,iECNA114_1301.ECNA114_2547,iECO103_1326.ECO103_0598,iECO26_1355.ECO26_5456,iECP_1309.ECP_0163,iECSP_1301.ECSP_0644,iECUMN_1333.ECUMN_0684,iECs_1301.ECs0629,iEcE24377_1341.EcE24377A_4865,iEcE24377_1341.EcE24377A_4866,iEcHS_1320.EcHS_A0641,iEcolC_1368.EcolC_0740,iG2583_1286.G2583_0753,iSBO_1134.SBO_0451,iSFV_1184.SFV_0538,iSbBS512_1146.SbBS512_E0492,iUMNK88_1353.UMNK88_5227,iZ_1308.Z0732	Bacteria	1MYYG@1224,1RRQ1@1236,3XPEY@561,COG0609@1,COG0609@2	NA|NA|NA	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1_02615	481805.EcolC_3055	8e-169	599.7	Escherichia	fepG	GO:0000041,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006826,GO:0008150,GO:0015343,GO:0015620,GO:0015682,GO:0015685,GO:0015688,GO:0015711,GO:0015850,GO:0015891,GO:0016020,GO:0022857,GO:0030001,GO:0042930,GO:0044464,GO:0044718,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0072512,GO:1901678		ko:K02015	ko02010,map02010	M00240			ko00000,ko00001,ko00002,ko02000	3.A.1.14		iAPECO1_1312.APECO1_1460,iEC55989_1330.EC55989_0581,iECABU_c1320.ECABU_c06390,iECED1_1282.ECED1_0586,iECOK1_1307.ECOK1_0601,iECP_1309.ECP_0621,iECS88_1305.ECS88_0628,iEcE24377_1341.EcE24377A_0609,iLF82_1304.LF82_0645,iNRG857_1313.NRG857_02670,iSBO_1134.SBO_0450,iSbBS512_1146.SbBS512_E0491,ic_1306.c0676	Bacteria	1NXD0@1224,1RS0J@1236,3XPG4@561,COG4779@1,COG4779@2	NA|NA|NA	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1_02616	316407.85674709	3.6e-151	540.8	Escherichia	fepC	GO:0000041,GO:0000166,GO:0003674,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006826,GO:0008144,GO:0008150,GO:0015343,GO:0015620,GO:0015682,GO:0015685,GO:0015688,GO:0015711,GO:0015850,GO:0015891,GO:0016020,GO:0016021,GO:0017076,GO:0022857,GO:0030001,GO:0030554,GO:0031224,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042930,GO:0043167,GO:0043168,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0044718,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0072512,GO:0097159,GO:0097367,GO:0098533,GO:0098796,GO:0098797,GO:1901265,GO:1901363,GO:1901678,GO:1902494,GO:1902495,GO:1904949,GO:1990351	3.6.3.34	ko:K02013	ko02010,map02010	M00240			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14		iAF1260.b0588,iB21_1397.B21_00544,iBWG_1329.BWG_0461,iE2348C_1286.E2348C_0490,iEC55989_1330.EC55989_0580,iECABU_c1320.ECABU_c06380,iECBD_1354.ECBD_3067,iECB_1328.ECB_00555,iECDH10B_1368.ECDH10B_0548,iECDH1ME8569_1439.ECDH1ME8569_0558,iECDH1ME8569_1439.EcDH1_3038,iECD_1391.ECD_00555,iECED1_1282.ECED1_0585,iECIAI1_1343.ECIAI1_0572,iECNA114_1301.ECNA114_0142,iECNA114_1301.ECNA114_0531,iECO103_1326.ECO103_0596,iECOK1_1307.ECOK1_0599,iECP_1309.ECP_0620,iECS88_1305.ECS88_0627,iECSE_1348.ECSE_0655,iECSF_1327.ECSF_0168,iECSF_1327.ECSF_0529,iECUMN_1333.ECUMN_0682,iECW_1372.ECW_m0643,iEKO11_1354.EKO11_3277,iETEC_1333.ETEC_0618,iEcDH1_1363.EcDH1_3038,iEcE24377_1341.EcE24377A_0607,iEcHS_1320.EcHS_A0639,iEcolC_1368.EcolC_3056,iJO1366.b0588,iLF82_1304.LF82_0642,iNRG857_1313.NRG857_02665,iSDY_1059.SDY_0519,iSFV_1184.SFV_0536,iUMN146_1321.UM146_14565,iUMNK88_1353.UMNK88_620,iUTI89_1310.UTI89_C0590,iWFL_1372.ECW_m0643,iY75_1357.Y75_RS03065,ic_1306.c0675	Bacteria	1MUNG@1224,1RRII@1236,3XMZN@561,COG1120@1,COG1120@2	NA|NA|NA	P	Probably responsible for energy coupling to the transport system
C1_02617	362663.ECP_0619	6.5e-199	699.9	Escherichia	fepE	GO:0000041,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006826,GO:0008150,GO:0015343,GO:0015620,GO:0015682,GO:0015685,GO:0015688,GO:0015711,GO:0015850,GO:0015891,GO:0016020,GO:0022857,GO:0030001,GO:0042930,GO:0044464,GO:0044718,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0072512,GO:1901678		ko:K05789,ko:K05790					ko00000,ko01005			iAF1260.b3785,iB21_1397.B21_03612,iBWG_1329.BWG_3467,iECBD_1354.ECBD_4254,iECB_1328.ECB_03663,iECDH10B_1368.ECDH10B_3974,iECDH1ME8569_1439.ECDH1ME8569_3667,iECD_1391.ECD_03663,iECH74115_1262.ECH74115_5218,iECIAI1_1343.ECIAI1_3972,iECSP_1301.ECSP_4833,iECUMN_1333.ECUMN_4310,iETEC_1333.ETEC_4067,iEcDH1_1363.EcDH1_4191,iEcE24377_1341.EcE24377A_4296,iEcHS_1320.EcHS_A4002,iJO1366.b3785,iSF_1195.SF3859,iS_1188.S3901,iSbBS512_1146.SbBS512_E4136,iUMNK88_1353.UMNK88_4594,iY75_1357.Y75_RS18155	Bacteria	1N0EC@1224,1RR0I@1236,3XMWK@561,COG3765@1,COG3765@2	NA|NA|NA	M	Ferric enterobactin transport protein FepE
C1_02618	469008.B21_00542	0.0	2526.1	Escherichia	entF	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009237,GO:0009238,GO:0009239,GO:0009366,GO:0009712,GO:0009713,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0018958,GO:0019184,GO:0019290,GO:0019438,GO:0019540,GO:0019748,GO:0019752,GO:0019842,GO:0031177,GO:0032991,GO:0033218,GO:0034641,GO:0036094,GO:0043038,GO:0043041,GO:0043043,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0046189,GO:0046483,GO:0047527,GO:0048037,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072341,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	6.3.2.14	ko:K02364	ko01053,ko01110,ko01130,map01053,map01110,map01130		R07644	RC00162,RC03046	ko00000,ko00001,ko01000,ko01008			iECO111_1330.ECO111_0616,iECO26_1355.ECO26_0661,iECSE_1348.ECSE_0653,iEcolC_1368.EcolC_3058	Bacteria	1QK4F@1224,1RPAG@1236,3XMWV@561,COG1020@1,COG1020@2,COG3319@1,COG3319@2	NA|NA|NA	Q	Activates the carboxylate group of L-serine via ATP- dependent PPi exchange reactions to the aminoacyladenylate, preparing that molecule for the final stages of enterobactin synthesis. Holo-EntF acts as the catalyst for the formation of the three amide and three ester bonds present in the cyclic (2,3- dihydroxybenzoyl)serine trimer enterobactin, using seryladenylate and acyl-holo-EntB (acylated with 2,3-dihydroxybenzoate by EntE)
C1_02619	199310.c0672	1.8e-36	157.9	Escherichia	ybdZ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K05375,ko:K07214	ko00261,ko01130,map00261,map01130	M00736	R10880	RC00064,RC00141,RC03296,RC03297,RC03298	ko00000,ko00001,ko00002				Bacteria	1N87J@1224,1SCB8@1236,3XQ0B@561,COG3251@1,COG3251@2	NA|NA|NA	S	Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)-serine. Plays a role in the catalytic function of EntF. It is required for adenylation of amino acids in non-ribosomal peptide biosynthesis
C1_02620	155864.EDL933_0654	1.2e-243	848.6	Escherichia	fes	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0008150,GO:0008152,GO:0008849,GO:0009056,GO:0009237,GO:0009238,GO:0009712,GO:0009987,GO:0016787,GO:0016788,GO:0018958,GO:0019336,GO:0019439,GO:0019614,GO:0019748,GO:0044237,GO:0044248,GO:0044424,GO:0044464,GO:0046214,GO:0046215,GO:0046483,GO:0046700,GO:0051186,GO:0051187,GO:0071704,GO:0090487,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616		ko:K07214					ko00000			iECNA114_1301.ECNA114_0527,iSbBS512_1146.SbBS512_E0486	Bacteria	1MXJN@1224,1RPMW@1236,3XM5Q@561,COG2382@1,COG2382@2	NA|NA|NA	P	esterase
C1_02621	481805.EcolC_3061	0.0	1526.1	Escherichia	fepA	GO:0000041,GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006826,GO:0006855,GO:0006873,GO:0006875,GO:0006879,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009279,GO:0009987,GO:0015031,GO:0015238,GO:0015267,GO:0015343,GO:0015399,GO:0015405,GO:0015450,GO:0015620,GO:0015682,GO:0015685,GO:0015688,GO:0015711,GO:0015833,GO:0015850,GO:0015891,GO:0015893,GO:0016020,GO:0016021,GO:0019725,GO:0019867,GO:0019904,GO:0022803,GO:0022804,GO:0022834,GO:0022836,GO:0022857,GO:0022884,GO:0022885,GO:0030001,GO:0030003,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031975,GO:0033036,GO:0033212,GO:0033214,GO:0042221,GO:0042493,GO:0042592,GO:0042886,GO:0042887,GO:0042891,GO:0042895,GO:0042912,GO:0042914,GO:0042930,GO:0043213,GO:0044425,GO:0044462,GO:0044464,GO:0044718,GO:0045184,GO:0045203,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0072512,GO:0098771,GO:1901678,GO:1904680		ko:K16089,ko:K19611	ko02020,map02020				ko00000,ko00001,ko02000	1.B.14.1,1.B.14.1.22,1.B.14.1.3,1.B.14.1.5,1.B.14.10		iECABU_c1320.ECABU_c06330,iECO103_1326.ECO103_2630,iECP_1309.ECP_0615,iLF82_1304.LF82_0640,iNRG857_1313.NRG857_02640,iSDY_1059.SDY_0512	Bacteria	1MUC1@1224,1RNHR@1236,3XNAQ@561,COG1629@1,COG4771@2	NA|NA|NA	P	This protein is involved in the initial step of iron uptake by binding ferrienterobactin (Fe-ENT), an iron chelatin siderophore that allows E.coli to extract iron from the environment. FepA also acts as a receptor for colicins B and D
C1_02622	155864.EDL933_0651	1.5e-117	428.7	Escherichia	entD	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008897,GO:0009058,GO:0009237,GO:0009238,GO:0009239,GO:0009366,GO:0009712,GO:0009713,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0018130,GO:0018958,GO:0019184,GO:0019290,GO:0019438,GO:0019540,GO:0019748,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0043043,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044550,GO:0046189,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	6.3.2.14	ko:K02362	ko01053,ko01110,ko01130,map01053,map01110,map01130		R07644	RC00162,RC03046	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_1466,iECO111_1330.ECO111_0612,iEcE24377_1341.EcE24377A_0601,iSSON_1240.SSON_0533,iUTI89_1310.UTI89_C0583	Bacteria	1MZK2@1224,1S968@1236,3XNT7@561,COG2977@1,COG2977@2	NA|NA|NA	H	Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)-serine. The serine trilactone serves as a scaffolding for the three catechol functionalities that provide hexadentate coordination for the tightly ligated iron(2 ) atoms. Plays an essential role in the assembly of the enterobactin by catalyzing the transfer of the 4'- phosphopantetheine (Ppant) moiety from coenzyme A to the apo- domains of both EntB (ArCP domain) and EntF (PCP domain) to yield their holo-forms which make them competent for the activation of 2,3-dihydroxybenzoate (DHB) and L-serine, respectively
C1_02623	155864.EDL933_0649	9.7e-18	95.1	Escherichia	hokE	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716		ko:K18922					ko00000,ko02048				Bacteria	1NER2@1224,1SD5D@1236,2ECM3@1,336J3@2,3XQ2J@561	NA|NA|NA	S	Hok/gef family
C1_02624	316407.85674703	1.3e-17	94.7	Gammaproteobacteria	hokE	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716		ko:K18922					ko00000,ko02048				Bacteria	1NER2@1224,1SD5D@1236,2ECM3@1,336J3@2	NA|NA|NA	S	Hok/gef family
C1_02625	316407.4062209	1.9e-219	768.1	Escherichia	ybdK	GO:0003674,GO:0003824,GO:0016874,GO:0016879		ko:K06048					ko00000,ko01000				Bacteria	1MX4N@1224,1RRZ1@1236,3XN9Q@561,COG2170@1,COG2170@2	NA|NA|NA	F	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C1_02626	316407.4062208	7.6e-36	156.0	Escherichia	ybdJ												Bacteria	1N36C@1224,1SA9U@1236,2DY8N@1,32V4Y@2,3XQ02@561	NA|NA|NA	S	Protein of unknown function (DUF1158)
C1_02627	155864.EDL933_0643	6.1e-66	256.5	Escherichia	ybdF												Bacteria	1RF0B@1224,1S4W1@1236,3XQZ7@561,COG2315@1,COG2315@2	NA|NA|NA	S	YjbR
C1_02628	155864.EDL933_0642	1.1e-118	432.6	Escherichia	nfnB	GO:0000166,GO:0003674,GO:0003824,GO:0004155,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0010181,GO:0016491,GO:0016645,GO:0016646,GO:0016651,GO:0016657,GO:0018545,GO:0018973,GO:0018974,GO:0019326,GO:0019439,GO:0032553,GO:0036094,GO:0042537,GO:0042802,GO:0043167,GO:0043168,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046256,GO:0046260,GO:0046263,GO:0048037,GO:0050662,GO:0055114,GO:0071704,GO:0072490,GO:0072491,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575	1.5.1.34	ko:K10679	ko00633,ko01120,map00633,map01120		R08014,R08017,R08042	RC00250	ko00000,ko00001,ko01000			iECUMN_1333.ECUMN_0668,iEcSMS35_1347.EcSMS35_0596,iJN746.PP_2432	Bacteria	1N95W@1224,1RSDH@1236,3XN05@561,COG0778@1,COG0778@2	NA|NA|NA	C	Oxygen-insensitive NAD(P)H nitroreductase
C1_02629	198214.SF0483	1.2e-227	795.4	Gammaproteobacteria	ybdG	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006950,GO:0006970,GO:0008150,GO:0008381,GO:0009628,GO:0009987,GO:0015267,GO:0016020,GO:0022803,GO:0022836,GO:0022857,GO:0033554,GO:0042802,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071214,GO:0071470,GO:0071944,GO:0104004		ko:K16053					ko00000,ko02000	1.A.23.4.5			Bacteria	1MVX9@1224,1RNBM@1236,COG0668@1,COG0668@2	NA|NA|NA	M	Mechanosensitive Ion channel
C1_02630	362663.ECP_0607	1.5e-253	881.7	Escherichia	pheP	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03293,ko:K11732,ko:K11734					ko00000,ko02000	2.A.3.1,2.A.3.1.1,2.A.3.1.3		iAPECO1_1312.APECO1_1472,iECW_1372.ECW_m0628,iEcE24377_1341.EcE24377A_0114,iEcolC_1368.EcolC_3070,iUTI89_1310.UTI89_C0576,iWFL_1372.ECW_m0628	Bacteria	1MUPS@1224,1RNK0@1236,3XQGC@561,COG1113@1,COG1113@2	NA|NA|NA	P	Permease that is involved in the transport across the cytoplasmic membrane of phenylalanine
C1_02631	316407.4062205	0.0	2009.2	Escherichia	cusA	GO:0000041,GO:0003674,GO:0005215,GO:0005375,GO:0005488,GO:0005507,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0006873,GO:0006875,GO:0006878,GO:0006950,GO:0008150,GO:0008324,GO:0009636,GO:0009987,GO:0010035,GO:0010038,GO:0010272,GO:0010273,GO:0015075,GO:0015080,GO:0015318,GO:0015673,GO:0015679,GO:0016020,GO:0016021,GO:0019725,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0031224,GO:0034220,GO:0035434,GO:0042221,GO:0042592,GO:0043167,GO:0043169,GO:0044425,GO:0044464,GO:0046688,GO:0046872,GO:0046873,GO:0046914,GO:0046915,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051234,GO:0055065,GO:0055070,GO:0055076,GO:0055080,GO:0055082,GO:0055085,GO:0060003,GO:0061687,GO:0065007,GO:0065008,GO:0071944,GO:0097501,GO:0098655,GO:0098660,GO:0098662,GO:0098754,GO:0098771,GO:1902601,GO:1990169		ko:K07787	ko02020,map02020				ko00000,ko00001,ko02000	2.A.6.1.4		iAF987.Gmet_1547,iB21_1397.B21_00525,iECBD_1354.ECBD_3087,iECB_1328.ECB_00536,iECD_1391.ECD_00536	Bacteria	1NUIV@1224,1SP6I@1236,3XP8C@561,COG3696@1,COG3696@2	NA|NA|NA	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1_02632	316407.4062198	1.7e-224	785.0	Escherichia	cusB	GO:0000041,GO:0003674,GO:0005215,GO:0005375,GO:0005488,GO:0005507,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0006873,GO:0006875,GO:0006878,GO:0006950,GO:0008150,GO:0008324,GO:0009636,GO:0009987,GO:0010035,GO:0010038,GO:0010272,GO:0010273,GO:0015075,GO:0015318,GO:0015679,GO:0019725,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030288,GO:0030313,GO:0031975,GO:0034220,GO:0035434,GO:0042221,GO:0042592,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0046688,GO:0046872,GO:0046873,GO:0046914,GO:0046915,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051234,GO:0055065,GO:0055070,GO:0055076,GO:0055080,GO:0055082,GO:0055085,GO:0060003,GO:0061687,GO:0065007,GO:0065008,GO:0097501,GO:0098655,GO:0098660,GO:0098662,GO:0098754,GO:0098771,GO:1990169		ko:K07798	ko02020,map02020				ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1		iECSF_1327.ECSF_0504	Bacteria	1MVAS@1224,1RPBZ@1236,3XP54@561,COG0845@1,COG0845@2	NA|NA|NA	M	Part of a cation efflux system that mediates resistance to copper and silver
C1_02633	316407.4062197	1.3e-54	218.8	Escherichia	cusF	GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005623,GO:0006873,GO:0006875,GO:0006878,GO:0006950,GO:0008150,GO:0009636,GO:0009987,GO:0010035,GO:0010038,GO:0010043,GO:0010272,GO:0010273,GO:0016530,GO:0016531,GO:0019725,GO:0030003,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042592,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0046688,GO:0046872,GO:0046914,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0055065,GO:0055070,GO:0055076,GO:0055080,GO:0055082,GO:0061687,GO:0065007,GO:0065008,GO:0097501,GO:0098754,GO:0098771,GO:0140104,GO:1990169		ko:K07810	ko02020,map02020				ko00000,ko00001	2.A.6.1.4		iAF1260.b0573,iAPECO1_1312.APECO1_1475,iBWG_1329.BWG_0444,iE2348C_1286.E2348C_0473,iEC042_1314.EC042_0607,iECABU_c1320.ECABU_c06220,iECDH10B_1368.ECDH10B_0531,iECDH1ME8569_1439.ECDH1ME8569_0541,iECED1_1282.ECED1_0565,iECIAI39_1322.ECIAI39_0548,iECNA114_1301.ECNA114_0504,iECOK1_1307.ECOK1_0582,iECP_1309.ECP_0604,iECS88_1305.ECS88_0610,iECSF_1327.ECSF_0503,iETEC_1333.ETEC_0601,iEcDH1_1363.EcDH1_3056,iEcHS_1320.EcHS_A0620,iEcolC_1368.EcolC_3073,iJO1366.b0573,iLF82_1304.LF82_0388,iNRG857_1313.NRG857_02575,iSFV_1184.SFV_0506,iSF_1195.SF0474,iSFxv_1172.SFxv_0522,iS_1188.S0482,iUMN146_1321.UM146_14650,iUMNK88_1353.UMNK88_602,iUTI89_1310.UTI89_C0573,iY75_1357.Y75_RS02975,ic_1306.c0659	Bacteria	1N4KG@1224,1S9YP@1236,3XQZW@561,COG5569@1,COG5569@2	NA|NA|NA	S	Part of a cation efflux system that mediates resistance to copper and silver. Binds one copper per polypeptide
C1_02634	316407.4062196	8.3e-249	865.9	Escherichia	cusC	GO:0000041,GO:0003674,GO:0005215,GO:0005375,GO:0005488,GO:0005507,GO:0006464,GO:0006497,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0006873,GO:0006875,GO:0006878,GO:0006950,GO:0008150,GO:0008152,GO:0008289,GO:0008324,GO:0009058,GO:0009059,GO:0009636,GO:0009987,GO:0010035,GO:0010038,GO:0010272,GO:0010273,GO:0015075,GO:0015318,GO:0016043,GO:0018345,GO:0019538,GO:0019725,GO:0019992,GO:0022607,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0034220,GO:0034645,GO:0035434,GO:0036211,GO:0042157,GO:0042158,GO:0042221,GO:0042592,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043543,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046688,GO:0046872,GO:0046873,GO:0046914,GO:0046915,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055065,GO:0055070,GO:0055076,GO:0055080,GO:0055082,GO:0055085,GO:0060003,GO:0061687,GO:0065003,GO:0065007,GO:0065008,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0097501,GO:0098655,GO:0098660,GO:0098662,GO:0098754,GO:0098771,GO:1901564,GO:1901566,GO:1901576,GO:1990169		ko:K07796,ko:K18139	ko01501,ko02020,ko02024,map01501,map02020,map02024	M00642,M00643,M00647,M00718,M00768,M00822			ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,1.B.17.3.4,1.B.17.3.5,2.A.6.2		iAPECO1_1312.APECO1_1476,iECOK1_1307.ECOK1_0581,iECS88_1305.ECS88_0609,iSFxv_1172.SFxv_0521,iS_1188.S0481,iUMN146_1321.UM146_14655,iUTI89_1310.UTI89_C0572	Bacteria	1MUA8@1224,1RMDA@1236,3XNE7@561,COG1538@1,COG1538@2	NA|NA|NA	M	Forms pores that allow passive diffusion of cations across the outer membrane. Part of a cation efflux system that mediates resistance to copper and silver
C1_02635	155864.EDL933_0634	1.3e-122	445.7	Escherichia													Bacteria	1MU67@1224,1RNWH@1236,3XM99@561,COG0745@1,COG0745@2	NA|NA|NA	K	Member of the two-component regulatory system CusS CusR. Activates the expression of cusCFBA
C1_02636	481805.EcolC_3076	2.1e-266	924.5	Escherichia	cusS	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010272,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046688,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070887,GO:0071241,GO:0071248,GO:0071280,GO:0071292,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.7.13.3	ko:K07644	ko02020,map02020	M00452,M00745			ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022				Bacteria	1QTV1@1224,1T1I6@1236,3XPE1@561,COG5002@1,COG5002@2	NA|NA|NA	T	Member of the two-component regulatory system CusS CusR. Copper ion sensor. Could also be a silver ion sensor. Activates CusR by phosphorylation
C1_02637	481805.EcolC_3077	0.0	1263.8	Escherichia	vgrG			ko:K11904	ko03070,map03070	M00334			ko00000,ko00001,ko00002,ko02044	3.A.23.1			Bacteria	1MU7Q@1224,1S0Z3@1236,3XRIC@561,COG3501@1,COG3501@2	NA|NA|NA	S	TIGRFAM type VI secretion system Vgr family protein
C1_02638	481805.EcolC_3078	5.9e-82	310.1	Gammaproteobacteria													Bacteria	1RACT@1224,1S3MK@1236,COG5435@1,COG5435@2	NA|NA|NA	S	DcrB
C1_02639	481805.EcolC_3079	0.0	2582.0	Escherichia	rhsB												Bacteria	1MVV1@1224,1SKYM@1236,3XPUS@561,COG3209@1,COG3209@2,COG4104@1,COG4104@2	NA|NA|NA	M	RHS Repeat
C1_02640	345341.KUTG_01726	3.4e-08	64.7	Actinobacteria													Bacteria	28XRW@1,2ISWH@201174,2ZJND@2	NA|NA|NA		
C1_02641	1166016.W5S_0054	6.9e-24	117.1	Pectobacterium													Bacteria	1MSP9@122277,1QFFS@1224,1TCPZ@1236,2ASC1@1,31HRA@2	NA|NA|NA	S	SUKH-3 immunity protein
C1_02642	481805.EcolC_3079	6.3e-51	206.5	Escherichia	rhsB												Bacteria	1MVV1@1224,1SKYM@1236,3XPUS@561,COG3209@1,COG3209@2,COG4104@1,COG4104@2	NA|NA|NA	M	RHS Repeat
C1_02643	481805.EcolC_2203	3.7e-218	763.8	Escherichia													Bacteria	1MXB5@1224,1RSAV@1236,3XQUD@561,COG5433@1,COG5433@2	NA|NA|NA	L	transposase
C1_02644	155864.EDL933_0625	0.0	1470.3	Escherichia	nfrB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.4.1.336	ko:K02359,ko:K11740,ko:K19003	ko00561,ko01100,ko04320,map00561,map01100,map04320		R02689	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003		GT2		Bacteria	1P7GR@1224,1RNP2@1236,3XNQZ@561,COG1215@1,COG1215@2	NA|NA|NA	M	Bacteriophage N4 adsorption protein B
C1_02645	481805.EcolC_3084	0.0	1967.2	Escherichia	nfrA	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944		ko:K11739					ko00000				Bacteria	1N6EA@1224,1T2BB@1236,3XPEU@561,COG4783@1,COG4783@2	NA|NA|NA	M	Bacteriophage N4 adsorption protein A
C1_02646	481805.EcolC_3085	3.1e-164	584.3	Escherichia	ybcH												Bacteria	1NVNA@1224,1S1MI@1236,2DBCW@1,2Z8FS@2,3XNQX@561	NA|NA|NA	S	Domain of unknown function (DUF4434)
C1_02647	155864.EDL933_0622	2.1e-137	495.0	Escherichia	envY	GO:0003674,GO:0003700,GO:0005575,GO:0006355,GO:0008150,GO:0009266,GO:0009628,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141		ko:K03755,ko:K11920,ko:K21905,ko:K21906					ko00000,ko03000				Bacteria	1R8WH@1224,1S13W@1236,3XQQ2@561,COG2207@1,COG2207@2	NA|NA|NA	K	Porin thermoregulatory protein EnvY
C1_02648	316407.85674700	1.9e-183	648.3	Escherichia	ompT	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009279,GO:0016020,GO:0016787,GO:0017171,GO:0019538,GO:0019867,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031975,GO:0043170,GO:0044238,GO:0044425,GO:0044462,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564	3.4.23.48,3.4.23.49	ko:K01355,ko:K08566,ko:K13520					ko00000,ko01000,ko01002				Bacteria	1MWE3@1224,1RRNQ@1236,3XN2E@561,COG4571@1,COG4571@2	NA|NA|NA	M	Protease that can cleave T7 RNA polymerase, ferric enterobactin receptor protein (FEP), antimicrobial peptide protamine and other proteins. This protease has a specificity for paired basic residues
C1_02649	1440052.EAKF1_ch0901c	2.3e-136	491.5	Escherichia	appY	GO:0003674,GO:0003700,GO:0006355,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009314,GO:0009605,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010165,GO:0010212,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016036,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042594,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141		ko:K03755,ko:K07780,ko:K11920,ko:K21905,ko:K21906	ko02020,map02020				ko00000,ko00001,ko03000				Bacteria	1Q19X@1224,1RPD4@1236,3XQUJ@561,COG2207@1,COG2207@2	NA|NA|NA	K	Helix-turn-helix domain
C1_02650	1147152.K7PGT9_9CAUD	2.9e-266	925.2	Siphoviridae													Viruses	4QE0G@10239,4QKKV@10699,4QSG4@28883,4QX6X@35237	NA|NA|NA	S	peptidoglycan catabolic process
C1_02651	155864.EDL933_1845	3.4e-106	391.0	Gammaproteobacteria	ompX			ko:K07804,ko:K11934	ko02020,map02020				ko00000,ko00001,ko02000	1.B.6.2.1			Bacteria	1RH8M@1224,1SE1S@1236,COG3637@1,COG3637@2	NA|NA|NA	M	Corresponds to locus_tag
C1_02652	155864.EDL933_1844	0.0	2231.4	Escherichia													Bacteria	1MXXZ@1224,1RNFD@1236,3XP1D@561,COG4733@1,COG4733@2	NA|NA|NA	S	Phage-related protein, tail component
C1_02653	199310.c3155	2e-87	328.6	Escherichia													Bacteria	1RD21@1224,1SA8A@1236,3XRHS@561,COG4723@1,COG4723@2	NA|NA|NA	S	Bacteriophage lambda tail assembly protein I
C1_02654	469008.B21_00748	4.6e-119	433.7	Escherichia	JD73_18915		3.5.1.28	ko:K01449,ko:K21471			R04112	RC00064,RC00141	ko00000,ko01000,ko01002,ko01011				Bacteria	1R053@1224,1T4F7@1236,3XRNI@561,COG0791@1,COG0791@2	NA|NA|NA	M	NlpC/P60 family
C1_02655	155864.EDL933_1841	1.2e-131	475.7	Escherichia	JD73_18910												Bacteria	1N0JB@1224,1S2IE@1236,3XQ3K@561,COG4672@1,COG4672@2	NA|NA|NA	S	Phage minor tail protein L
C1_02656	199310.c3159	5.7e-55	219.9	Escherichia	JD73_18905												Bacteria	1N8H3@1224,1SCEF@1236,3XQ54@561,COG4718@1,COG4718@2	NA|NA|NA	S	Phage minor tail protein
C1_02657	754331.AEME01000001_gene3093	0.0	1536.5	Escherichia	sca1												Bacteria	1MU81@1224,1RS6P@1236,3XMR1@561,COG1196@1,COG1196@2	NA|NA|NA	D	Escherichia coli O157 H7 ortholog z2140
C1_02658	155864.EDL933_1838	6.1e-65	253.4	Escherichia	GJ12_01675												Bacteria	1NCN9@1224,1SCN0@1236,2E7G2@1,331YY@2,3XQ4S@561	NA|NA|NA	S	Minor tail protein T
C1_02659	481805.EcolC_2102	1.4e-61	242.3	Escherichia													Bacteria	1NDPN@1224,1SDK8@1236,2EBXR@1,335X3@2,3XQ49@561	NA|NA|NA	S	tail component of prophage
C1_02660	1116472.MGMO_198c00010	9.3e-130	469.5	Gammaproteobacteria	GJ12_03320												Bacteria	1R7SX@1224,1RP1Q@1236,COG5492@1,COG5492@2	NA|NA|NA	N	Lambda phage tail tube protein, TTP
C1_02661	1116472.MGMO_198c00020	2.4e-68	264.6	Gammaproteobacteria													Bacteria	1RK18@1224,1T1CH@1236,2AFU1@1,315WD@2	NA|NA|NA	S	Phage minor tail protein U
C1_02662	362663.ECP_1175	1.3e-83	315.8	Escherichia	JD73_18875												Bacteria	1R6UI@1224,1S10J@1236,295PD@1,2ZT0R@2,3XPQS@561	NA|NA|NA	S	prophage
C1_02663	362663.ECP_1174	5.2e-62	243.4	Escherichia	GJ11_17070												Bacteria	1N2KU@1224,1SA0Q@1236,2E071@1,32VUX@2,3XPSI@561	NA|NA|NA	S	head-tail joining protein of prophage
C1_02664	362663.ECP_1173	9.2e-60	236.1	Escherichia	fI_3												Bacteria	1N26B@1224,1S9BF@1236,2CCH7@1,32RVP@2,3XPPJ@561	NA|NA|NA	L	DNA packaging protein FI
C1_02665	199310.c3168	5.9e-191	673.3	Escherichia	JD73_18860												Bacteria	1PPA2@1224,1RZPQ@1236,2C57E@1,2Z8WK@2,3XQFJ@561	NA|NA|NA	S	Phage major capsid protein E
C1_02666	754331.AEME01000001_gene3083	9.8e-55	219.2	Escherichia	D_2												Bacteria	1RIEC@1224,1SQVN@1236,2CJRM@1,31641@2,3XPTM@561	NA|NA|NA	S	Bacteriophage lambda head decoration protein D
C1_02667	502347.ESCAB7627_3658	3.6e-233	813.9	Escherichia	sppA			ko:K04773,ko:K21511					ko00000,ko01000,ko01002				Bacteria	1QGPW@1224,1RZZW@1236,3XNW2@561,COG0616@1,COG0616@2	NA|NA|NA	OU	Peptidase family S49
C1_02668	481805.EcolC_2093	7.5e-310	1068.9	Escherichia	JD73_18735												Bacteria	1MVN4@1224,1RPUT@1236,3XQ5D@561,COG5511@1,COG5511@2	NA|NA|NA	S	Phage portal protein, lambda family
C1_02669	199310.c3172	5.7e-29	132.9	Escherichia	W												Bacteria	1NJ8E@1224,1SHCP@1236,2EHEK@1,33B6I@2,3XQ04@561	NA|NA|NA	S	gpW
C1_02670	469008.B21_00731	0.0	1327.0	Escherichia	A		3.1.21.4	ko:K21512					ko00000,ko01000				Bacteria	1MVS3@1224,1RRH5@1236,3XNU1@561,COG5525@1,COG5525@2	NA|NA|NA	S	Phage terminase large subunit (GpA)
C1_02671	502347.ESCAB7627_3662	2.3e-93	348.2	Escherichia	nohB			ko:K22014					ko00000				Bacteria	1RFQ1@1224,1S33Z@1236,3XQB6@561,COG4220@1,COG4220@2	NA|NA|NA	L	DNA packaging
C1_02672	199310.c1440	2.1e-54	218.4	Bacteria	ydfO												Bacteria	COG5562@1,COG5562@2	NA|NA|NA	E	phage envelope protein
C1_02674	432198.K7P7S3_9CAUD	4.6e-85	320.5	Caudovirales													Viruses	4QAPV@10239,4QQ0U@28883,4QV7H@35237	NA|NA|NA	S	regulation of transcription, DNA-dependent
C1_02675	432201.K7P710_9CAUD	2.1e-68	265.0	Siphoviridae													Viruses	4QB5H@10239,4QMVY@10699,4QPQR@28883,4QV85@35237	NA|NA|NA	S	Bacteriophage Rz lysis protein
C1_02676	469008.B21_00513	7e-89	333.2	Escherichia	rrrD	GO:0001906,GO:0001907,GO:0003674,GO:0003796,GO:0003824,GO:0004553,GO:0008150,GO:0016032,GO:0016787,GO:0016798,GO:0019048,GO:0019058,GO:0019076,GO:0031640,GO:0035821,GO:0035890,GO:0035891,GO:0039633,GO:0040011,GO:0044003,GO:0044004,GO:0044364,GO:0044403,GO:0044419,GO:0044659,GO:0044661,GO:0051701,GO:0051704,GO:0051817,GO:0051818,GO:0051883,GO:0052126,GO:0052192,GO:0061783	3.2.1.17	ko:K01185					ko00000,ko01000				Bacteria	1MZJD@1224,1S6BA@1236,3XPV0@561,COG3772@1,COG3772@2	NA|NA|NA	G	Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity. Exhibits lytic activity against E.coli and S.typhi cell wall substrate
C1_02677	199310.c1561	2.3e-33	147.5	Escherichia	essD	GO:0001906,GO:0001907,GO:0008150,GO:0016032,GO:0019048,GO:0019058,GO:0019076,GO:0031640,GO:0035821,GO:0035890,GO:0035891,GO:0039633,GO:0040011,GO:0044003,GO:0044004,GO:0044364,GO:0044403,GO:0044419,GO:0044659,GO:0044661,GO:0051701,GO:0051704,GO:0051817,GO:0051818,GO:0051883,GO:0052126,GO:0052192											Bacteria	1NAY0@1224,1SFBJ@1236,2E3SS@1,32YQ9@2,3XQ2B@561	NA|NA|NA	S	Lysis protein S homolog from lambdoid prophage
C1_02678	155864.EDL933_0290	1.8e-61	242.7	Bacteria				ko:K03755,ko:K11920,ko:K21905,ko:K21906					ko00000,ko03000				Bacteria	COG2207@1,COG2207@2	NA|NA|NA	K	Transcriptional regulator
C1_02679	571.MC52_21035	4.4e-140	504.2	Gammaproteobacteria	ybgA												Bacteria	1MXYZ@1224,1RNMF@1236,COG1683@1,COG1683@2,COG3272@1,COG3272@2	NA|NA|NA	S	Conserved Protein
C1_02680	754331.AEME01000001_gene3071	3e-98	364.4	Escherichia	blc			ko:K03098,ko:K07071					ko00000,ko04147				Bacteria	1RDAI@1224,1S3PW@1236,3XQF6@561,COG3040@1,COG3040@2	NA|NA|NA	M	Lipocalin-like domain
C1_02681	754331.AEME01000001_gene3070	6.7e-68	263.1	Escherichia													Bacteria	1N2ZI@1224,1SB8W@1236,2CAXP@1,31HHM@2,3XQZ1@561	NA|NA|NA	S	Phage antitermination protein Q
C1_02683	199310.c1557	4.1e-62	243.8	Escherichia	rusA	GO:0000217,GO:0000400,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008821,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363	3.1.22.4	ko:K01160					ko00000,ko01000,ko03400				Bacteria	1N92D@1224,1SDZ5@1236,3XPWD@561,COG4570@1,COG4570@2	NA|NA|NA	L	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of
C1_02684	469008.B21_00504	2e-48	198.0	Escherichia	ybcO												Bacteria	1N2ZM@1224,1S9DB@1236,2D7I9@1,32TP3@2,3XR05@561	NA|NA|NA	S	Protein of unknown function (DUF1364)
C1_02685	155864.EDL933_1813	1e-23	115.2	Gammaproteobacteria	ninE												Bacteria	1N848@1224,1SDC4@1236,2E83F@1,332HC@2	NA|NA|NA		
C1_02686	316407.85674682	1.4e-80	305.4	Escherichia	ybcN	GO:0000217,GO:0000405,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0097159,GO:1901363											Bacteria	1REYJ@1224,1S4XF@1236,2999H@1,2ZWCQ@2,3XQP7@561	NA|NA|NA	S	bubble DNA binding
C1_02687	1219080.VEZ01S_52_00530	4.2e-121	441.8	Vibrionales													Bacteria	1PEPJ@1224,1RQFX@1236,1XW1A@135623,COG1196@1,COG1196@2	NA|NA|NA	D	T5orf172
C1_02688	155864.EDL933_1809	3e-42	177.6	Gammaproteobacteria													Bacteria	1NG7D@1224,1SE2F@1236,2EAS2@1,334U5@2	NA|NA|NA		
C1_02689	155864.EDL933_1808	5.9e-126	456.8	Escherichia													Bacteria	1R850@1224,1S00X@1236,2CB53@1,2ZB3U@2,3XP5T@561	NA|NA|NA	S	Replication protein P
C1_02690	362663.ECP_1149	1.6e-185	655.2	Escherichia													Bacteria	1RFD2@1224,1T2T6@1236,2DBGR@1,2Z95I@2,3XPT2@561	NA|NA|NA	S	Bacteriophage replication protein O
C1_02691	362663.ECP_1148	1.3e-93	349.0	Escherichia													Bacteria	1RBQ0@1224,1S2C7@1236,28ZM9@1,2ZMCI@2,3XPJD@561	NA|NA|NA	S	Putative bacterial toxin ydaT
C1_02692	362663.ECP_1147	2e-35	154.5	Escherichia													Bacteria	1N8J3@1224,1SE3H@1236,3XR4M@561,COG4197@1,COG4197@2	NA|NA|NA	S	Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT
C1_02693	754331.AEME01000001_gene3278	3.4e-88	330.9	Escherichia													Bacteria	1R80S@1224,1RQVU@1236,3XQAK@561,COG2932@1,COG2932@2	NA|NA|NA	K	Peptidase S24-like
C1_02694	634499.EpC_13170	3.9e-59	235.0	Gammaproteobacteria													Bacteria	1N18S@1224,1SC8H@1236,2CDR7@1,32TTG@2	NA|NA|NA		
C1_02695	634499.EpC_13160	3.3e-83	315.1	Gammaproteobacteria													Bacteria	1RKTS@1224,1S6FZ@1236,29597@1,2ZSMJ@2	NA|NA|NA	S	Protein of unknown function (DUF3037)
C1_02696	362663.ECP_1143	5e-33	146.4	Escherichia													Bacteria	1N93A@1224,1SFWD@1236,2E1W4@1,32X5C@2,3XR1J@561	NA|NA|NA		
C1_02697	155864.EDL933_1360	4.6e-48	196.8	Escherichia													Bacteria	1N07R@1224,1SAZH@1236,2CE2G@1,32RYQ@2,3XR1Y@561	NA|NA|NA	S	Host-nuclease inhibitor protein Gam
C1_02698	155864.EDL933_1359	3.1e-147	527.7	Escherichia	bet			ko:K07455					ko00000,ko03400				Bacteria	1QWBR@1224,1T2T2@1236,3XQKB@561,COG3723@1,COG3723@2	NA|NA|NA	L	RecT family
C1_02699	194949.Q7Y2M8_9CAUD	2.5e-129	468.0	Podoviridae		GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360											Viruses	4QCB0@10239,4QNP9@10744,4QPFH@28883,4QX81@35237	NA|NA|NA	S	YqaJ-like viral recombinase domain
C1_02700	469008.B21_00711	2e-25	120.9	Escherichia													Bacteria	1NN6X@1224,1SGHZ@1236,2EICE@1,33C3Q@2,3XRE9@561	NA|NA|NA	S	Protein of unknown function (DUF1317)
C1_02701	1147146.K7P742_9CAUD	7.9e-25	119.0	Siphoviridae													Viruses	4QDUJ@10239,4QMKT@10699,4QRKJ@28883,4QVKT@35237	NA|NA|NA	S	Protein of unknown function (DUF1382)
C1_02702	199310.c1532	5.4e-46	189.9	Gammaproteobacteria	ybl17												Bacteria	1NPA1@1224,1SHE2@1236,2CBE4@1,33KWN@2	NA|NA|NA		
C1_02703	362663.ECP_1138	1.8e-33	147.9	Gammaproteobacteria				ko:K06204	ko02026,map02026				ko00000,ko00001,ko03000,ko03009,ko03021				Bacteria	1NGS3@1224,1SGUS@1236,COG1734@1,COG1734@2	NA|NA|NA	T	Phage conjugal plasmid C-4 type zinc finger protein, TraR family
C1_02704	469008.B21_00493	4.8e-47	193.4	Gammaproteobacteria													Bacteria	1N56K@1224,1S9ME@1236,2C9JN@1,32UXM@2	NA|NA|NA	S	Domain of unknown function (DUF4222)
C1_02705	469008.B21_00491	1.6e-221	775.0	Escherichia	intD	GO:0000150,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0008979,GO:0009009,GO:0009987,GO:0015074,GO:0016032,GO:0019042,GO:0019043,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051704,GO:0071704,GO:0075713,GO:0090304,GO:0140097,GO:1901360											Bacteria	1MWBN@1224,1RPD0@1236,3XN2J@561,COG0582@1,COG0582@2	NA|NA|NA	L	Integrase from the cryptic lambdoic prophage DLP12. Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome
C1_02707	469008.B21_00490	1.2e-109	402.5	Escherichia	fimZ		3.1.4.52	ko:K02282,ko:K07686,ko:K07688,ko:K07690,ko:K13246	ko02020,ko05111,ko05133,map02020,map05111,map05133	M00473,M00477,M00697	R08991	RC00296	ko00000,ko00001,ko00002,ko01000,ko01504,ko02022,ko02035,ko02044				Bacteria	1Q0DT@1224,1RY1Z@1236,3XQGX@561,COG2197@1,COG2197@2	NA|NA|NA	K	intracellular signal transduction
C1_02708	469008.B21_00489	9.8e-94	349.4	Escherichia	fimF	GO:0007155,GO:0008150,GO:0022610		ko:K07348,ko:K07355					ko00000,ko02035,ko02044				Bacteria	1RGDK@1224,1S5NU@1236,3XQQY@561,COG3539@1,COG3539@2	NA|NA|NA	NU	Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes
C1_02709	155864.EDL933_0618	3.5e-188	664.1	Escherichia	fimH	GO:0007155,GO:0008150,GO:0022610		ko:K07350,ko:K07356					ko00000,ko02035,ko02044				Bacteria	1R5U6@1224,1RR81@1236,3XQQE@561,COG3539@1,COG3539@2	NA|NA|NA	NU	Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes
C1_02710	469008.B21_00487	0.0	1762.3	Escherichia	sfmD	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0009279,GO:0009297,GO:0009987,GO:0015267,GO:0015288,GO:0015473,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0022803,GO:0022829,GO:0022857,GO:0030030,GO:0030031,GO:0030312,GO:0030313,GO:0031975,GO:0043711,GO:0044085,GO:0044462,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071840,GO:0071944		ko:K07347,ko:K07354	ko05133,map05133				ko00000,ko00001,ko02000,ko02035,ko02044	1.B.11.3			Bacteria	1MUHE@1224,1RMPU@1236,3XQTP@561,COG3188@1,COG3188@2	NA|NA|NA	NU	Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes. Probably involved in the export and assembly of fimbrial subunits across the outer membrane
C1_02711	34506.g5073	6e-123	446.8	Bilateria													Metazoa	2EJ5M@1,2SPE7@2759,3AM55@33154,3C0DV@33208,3DGWF@33213	NA|NA|NA	S	Pili assembly chaperone PapD, C-terminal domain
C1_02712	155864.EDL933_0615	4.8e-91	340.5	Escherichia	fimA	GO:0005575,GO:0005623,GO:0007155,GO:0008150,GO:0009289,GO:0022610,GO:0042995,GO:0044464		ko:K07345,ko:K07352	ko05133,map05133				ko00000,ko00001,ko02035,ko02044				Bacteria	1QI7Y@1224,1S07V@1236,3XQCR@561,COG3539@1,COG3539@2	NA|NA|NA	NU	Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes
C1_02713	316407.85674666	7e-161	573.2	Escherichia	folD	GO:0003674,GO:0003824,GO:0004477,GO:0004486,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0019752,GO:0034641,GO:0042558,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0055114,GO:0071704,GO:1901360,GO:1901564	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000			iSDY_1059.SDY_0281	Bacteria	1MWU4@1224,1RNSW@1236,3XMYB@561,COG0190@1,COG0190@2	NA|NA|NA	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C1_02714	1440052.EAKF1_ch0925	2.8e-31	140.6	Escherichia	yaaA	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576		ko:K14761					ko00000,ko03009				Bacteria	1N7NW@1224,1SCJU@1236,3XQ0A@561,COG2501@1,COG2501@2	NA|NA|NA	S	translation
C1_02715	155864.EDL933_0612	7.3e-97	359.8	Escherichia	ybcI	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K07038					ko00000				Bacteria	1RBHW@1224,1S2F9@1236,3XPG8@561,COG1988@1,COG1988@2	NA|NA|NA	S	LexA-binding, inner membrane-associated putative hydrolase
C1_02716	199310.c0642	1.3e-270	938.3	Escherichia	cysS	GO:0000166,GO:0001871,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030246,GO:0030247,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065	6.1.1.16,6.3.1.13	ko:K01883,ko:K15526	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iECUMN_1333.ECUMN_0566,iJN746.PP_2905	Bacteria	1MV8H@1224,1RP5K@1236,3XMKF@561,COG0215@1,COG0215@2	NA|NA|NA	J	Belongs to the class-I aminoacyl-tRNA synthetase family
C1_02717	1440052.EAKF1_ch0928	5.7e-91	340.1	Escherichia	ppiB	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564	2.7.11.1,5.2.1.8	ko:K03767,ko:K03768,ko:K08884	ko01503,ko04217,map01503,map04217				ko00000,ko00001,ko01000,ko01001,ko03110,ko04147				Bacteria	1R9ZQ@1224,1S222@1236,3XMU9@561,COG0652@1,COG0652@2	NA|NA|NA	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C1_02718	198214.SF0455	3.2e-135	487.6	Gammaproteobacteria	lpxH	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008758,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019637,GO:0019897,GO:0019898,GO:0030145,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	3.6.1.54	ko:K03269	ko00540,ko01100,map00540,map01100	M00060	R04549	RC00002	ko00000,ko00001,ko00002,ko01000,ko01005			iE2348C_1286.E2348C_0457	Bacteria	1N3U7@1224,1RP1X@1236,COG2908@1,COG2908@2	NA|NA|NA	S	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1_02719	155864.EDL933_0608	2.3e-87	328.2	Escherichia	purE	GO:0003674,GO:0003824,GO:0004638,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0016853,GO:0016866,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034023,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000			iETEC_1333.ETEC_0575,iJN746.PP_5336,iPC815.YPO3076,iUTI89_1310.UTI89_C0551	Bacteria	1RCWJ@1224,1S3VN@1236,3XNQ8@561,COG0041@1,COG0041@2	NA|NA|NA	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C1_02720	469008.B21_00477	4.7e-207	726.9	Escherichia	purK	GO:0000166,GO:0003674,GO:0003824,GO:0004638,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016829,GO:0016830,GO:0016831,GO:0016874,GO:0016879,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034028,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000			iECUMN_1333.ECUMN_0562,iYL1228.KPN_00477	Bacteria	1MU70@1224,1RQEI@1236,3XN0K@561,COG0026@1,COG0026@2	NA|NA|NA	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C1_02721	469008.B21_00476	5.5e-161	573.5	Escherichia	arcC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200		R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000			iE2348C_1286.E2348C_0454,iECED1_1282.ECED1_0540,iECIAI39_1322.ECIAI39_3289,iECUMN_1333.ECUMN_0561,iEcE24377_1341.EcE24377A_0559,iEcHS_1320.EcHS_A0383,iG2583_1286.G2583_0641,iJN746.PP_0999	Bacteria	1MWXC@1224,1RP78@1236,3XQ99@561,COG0549@1,COG0549@2	NA|NA|NA	F	Belongs to the carbamate kinase family
C1_02722	155864.EDL933_0605	3.4e-157	560.8	Escherichia	ylbF												Bacteria	1N0UA@1224,1S1HZ@1236,2DBVD@1,2ZBAJ@2,3XQE1@561	NA|NA|NA	S	Protein of unknown function (DUF2877)
C1_02723	469008.B21_00474	7.9e-238	829.3	Escherichia	sucD		6.2.1.5	ko:K01902,ko:K02381	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000			iE2348C_1286.E2348C_0608	Bacteria	1MX67@1224,1RQEG@1236,3XQNV@561,COG0074@1,COG0074@2	NA|NA|NA	C	Protein of unknown function (DUF1116)
C1_02724	481805.EcolC_3104	4.4e-305	1053.1	Escherichia	sucD	GO:0001539,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006928,GO:0008150,GO:0009361,GO:0009987,GO:0032991,GO:0040011,GO:0042709,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588,GO:1902494	6.2.1.5	ko:K01902,ko:K02381	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000			iE2348C_1286.E2348C_0608	Bacteria	1MWWN@1224,1RME7@1236,3XQJD@561,COG0074@1,COG0074@2	NA|NA|NA	C	multicopy suppressor of dominant negative ftsH
C1_02725	316407.85674655	3.9e-198	697.2	Escherichia	allD	GO:0000255,GO:0000256,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006807,GO:0008150,GO:0008152,GO:0009040,GO:0009056,GO:0009442,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0034641,GO:0042737,GO:0043603,GO:0043605,GO:0044237,GO:0044248,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0055114,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	1.1.1.130,1.1.1.350	ko:K00073,ko:K08092,ko:K13574	ko00040,ko00053,ko00230,ko01120,map00040,map00053,map00230,map01120		R02637,R02639,R02935,R02936	RC00169,RC00238	ko00000,ko00001,ko01000			iEC042_1314.EC042_0560,iEC55989_1330.EC55989_4032,iECIAI1_1343.ECIAI1_3742,iECO103_1326.ECO103_4659,iECO111_1330.ECO111_4395,iECO26_1355.ECO26_5026,iECSE_1348.ECSE_3851,iECW_1372.ECW_m3849,iEKO11_1354.EKO11_0151,iSF_1195.SF3619,iSFxv_1172.SFxv_3943,iS_1188.S4150,iWFL_1372.ECW_m3849	Bacteria	1MWQY@1224,1RSKW@1236,3XQXU@561,COG2055@1,COG2055@2	NA|NA|NA	C	AllD plays a pivotal role as a metabolic branch-point enzyme in nitrogen utilization via the assimilation of allantoin. It is able to utilize allantoin as a sole source of nitrogen under anaerobic conditions. Catalyzes the oxidation of ureidoglycolate to oxalurate
C1_02726	316407.85674654	1.8e-242	844.7	Escherichia	allC	GO:0000255,GO:0000256,GO:0003674,GO:0003824,GO:0005488,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009442,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0017144,GO:0030145,GO:0034641,GO:0042737,GO:0043167,GO:0043169,GO:0043603,GO:0043605,GO:0044237,GO:0044248,GO:0044270,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0047652,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	3.5.1.6,3.5.1.87,3.5.3.9	ko:K02083,ko:K06016	ko00230,ko00240,ko01100,ko01120,map00230,map00240,map01100,map01120	M00046	R00905,R02423,R04666	RC00064,RC00096	ko00000,ko00001,ko00002,ko01000,ko01002			iECH74115_1262.ECH74115_0617,iECSP_1301.ECSP_0590,iECUMN_1333.ECUMN_0556,iECs_1301.ECs0578,iZ_1308.Z0671	Bacteria	1MVUX@1224,1RPPD@1236,3XPWH@561,COG0624@1,COG0624@2	NA|NA|NA	E	Involved in the anaerobic nitrogen utilization via the assimilation of allantoin. Catalyzes specifically the hydrolysis of allantoate to yield CO2, NH3 and S-ureidoglycine, which is unstable and readily undergoes a second deamination by S-ureidoglycine aminohydrolase AllE to yield S-ureidoglycolate and NH3. In vivo, the spontaneous release of S-ureidoglycolate and ammonia from S- ureidoglycine appears to be too slow to sustain an efficient flux of nitrogen
C1_02727	199310.c0629	1.6e-151	542.0	Escherichia	ylbA	GO:0003674,GO:0003824,GO:0005488,GO:0016787,GO:0016810,GO:0016813,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0071522	3.5.3.26	ko:K14977	ko00230,ko01120,map00230,map01120		R05554	RC01419	ko00000,ko00001,ko01000				Bacteria	1MW60@1224,1RQFK@1236,3XQS8@561,COG3257@1,COG3257@2	NA|NA|NA	S	Involved in the anaerobic nitrogen utilization via the assimilation of allantoin. Catalyzes the second stereospecific hydrolysis reaction (deamination) of the allantoin degradation pathway, producing S-ureidoglycolate and ammonia from S- ureidoglycine
C1_02728	155864.EDL933_0599	4.5e-208	730.3	Escherichia	glxK	GO:0003674,GO:0003824,GO:0006066,GO:0006081,GO:0006082,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009436,GO:0009441,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016491,GO:0016661,GO:0016662,GO:0016740,GO:0016772,GO:0017144,GO:0019752,GO:0032787,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0043798,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046185,GO:0046296,GO:0046395,GO:0046487,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616	2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130		R08572	RC00002,RC00428	ko00000,ko00001,ko01000			iECO103_1326.ECO103_0486,iECs_1301.ECs4002,iG2583_1286.G2583_3846	Bacteria	1MVG9@1224,1RMC6@1236,3XMNZ@561,COG1929@1,COG1929@2	NA|NA|NA	G	Belongs to the glycerate kinase type-1 family
C1_02729	469008.B21_00468	1.9e-239	834.7	Escherichia	ybbY	GO:0003674,GO:0005215,GO:0005345,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006863,GO:0008150,GO:0015205,GO:0015851,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0042906,GO:0042907,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072530,GO:1904823											Bacteria	1PD7V@1224,1RZ18@1236,3XQPF@561,COG2233@1,COG2233@2	NA|NA|NA	F	xanthine transmembrane transporter activity
C1_02730	469008.B21_00467	1.3e-265	921.8	Gammaproteobacteria	allB	GO:0000255,GO:0000256,GO:0003674,GO:0003824,GO:0004038,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009112,GO:0009442,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0017144,GO:0019439,GO:0034641,GO:0042737,GO:0043167,GO:0043169,GO:0043603,GO:0043605,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	3.5.2.5	ko:K01466	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R02425	RC00680	ko00000,ko00001,ko00002,ko01000			iEC042_1314.EC042_0555	Bacteria	1MW10@1224,1RMQC@1236,COG0044@1,COG0044@2	NA|NA|NA	F	Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides
C1_02731	316407.85674649	2.1e-271	941.0	Escherichia	ybbW	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0015205,GO:0015851,GO:0016020,GO:0022857,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944		ko:K03457,ko:K10975					ko00000,ko02000	2.A.39,2.A.39.3.8		iAPECO1_1312.APECO1_1504,iE2348C_1286.E2348C_0444,iECABU_c1320.ECABU_c05900,iECNA114_1301.ECNA114_0488,iECOK1_1307.ECOK1_0493,iECP_1309.ECP_0571,iECS88_1305.ECS88_0510,iECSF_1327.ECSF_0473,iLF82_1304.LF82_2567,iNRG857_1313.NRG857_02415,iUMN146_1321.UM146_14805,iUTI89_1310.UTI89_C0539,ic_1306.c0625	Bacteria	1MV18@1224,1RMZU@1236,3XQNS@561,COG1953@1,COG1953@2	NA|NA|NA	FH	Allantoin transport protein
C1_02732	316407.85674647	2.5e-158	564.7	Escherichia	glxR	GO:0000255,GO:0000256,GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008679,GO:0009056,GO:0009436,GO:0009442,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0019752,GO:0032787,GO:0033554,GO:0034641,GO:0042737,GO:0043436,GO:0043603,GO:0043605,GO:0044237,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046185,GO:0046395,GO:0046483,GO:0046487,GO:0046700,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0072329,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	1.1.1.60	ko:K00042	ko00630,ko01100,map00630,map01100		R01745,R01747	RC00099	ko00000,ko00001,ko01000				Bacteria	1MUGU@1224,1RQ2D@1236,3XQ73@561,COG2084@1,COG2084@2	NA|NA|NA	I	2-hydroxy-3-oxopropionate reductase
C1_02733	481805.EcolC_3114	6.3e-153	546.6	Escherichia	hyi	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006082,GO:0008150,GO:0008152,GO:0008903,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019752,GO:0032787,GO:0042802,GO:0042803,GO:0043436,GO:0044237,GO:0044281,GO:0046487,GO:0046983,GO:0071704	5.3.1.22,5.3.1.35	ko:K01816,ko:K22131	ko00630,ko01100,map00630,map01100		R01394	RC00511	ko00000,ko00001,ko01000			iECO103_1326.ECO103_0481,iECO111_1330.ECO111_0541,iECO26_1355.ECO26_0541	Bacteria	1MV53@1224,1RQF9@1236,3XQA5@561,COG3622@1,COG3622@2	NA|NA|NA	G	Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde). Does not catalyze the isomerization of D-fructose to D-glucose or that of D-xylulose to D-xylose. Also does not catalyze racemization of serine, alanine, glycerate or lactate
C1_02734	155864.EDL933_0592	0.0	1170.2	Escherichia	gcl	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006066,GO:0006081,GO:0006082,GO:0008150,GO:0008152,GO:0009028,GO:0009056,GO:0009436,GO:0009441,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016831,GO:0017144,GO:0019752,GO:0019842,GO:0030976,GO:0032787,GO:0034308,GO:0034310,GO:0036094,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046185,GO:0046296,GO:0046395,GO:0046487,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0071949,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575,GO:1901615,GO:1901616,GO:1901681	4.1.1.47	ko:K01608	ko00630,ko01100,map00630,map01100		R00013	RC00899	ko00000,ko00001,ko01000			iEcHS_1320.EcHS_A0581,iSFV_1184.SFV_0474	Bacteria	1MV88@1224,1RW45@1236,3XQHP@561,COG3960@1,COG3960@2	NA|NA|NA	S	Catalyzes the condensation of two molecules of glyoxylate to give 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde)
C1_02735	199310.c0621	7.1e-147	526.6	Escherichia	allR	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0033554,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K10973,ko:K13641					ko00000,ko03000				Bacteria	1R5WB@1224,1RZAS@1236,3XQPE@561,COG1414@1,COG1414@2	NA|NA|NA	K	IclR helix-turn-helix domain
C1_02736	155864.EDL933_0590	2.6e-88	331.3	Escherichia	allA	GO:0003674,GO:0003824,GO:0016829,GO:0016840,GO:0016842,GO:0050385	4.3.2.3	ko:K01483	ko00230,ko01100,map00230,map01100		R00776	RC00153,RC00379	ko00000,ko00001,ko01000			iAF1260.b0505,iBWG_1329.BWG_0382,iECDH10B_1368.ECDH10B_0461,iECDH1ME8569_1439.ECDH1ME8569_0489,iEcDH1_1363.EcDH1_3107,iJO1366.b0505,iJR904.b0505,iY75_1357.Y75_RS02595	Bacteria	1RH5G@1224,1T0X7@1236,3XQTI@561,COG3194@1,COG3194@2	NA|NA|NA	F	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the anaerobic utilization of allantoin as sole nitrogen source. Reinforces the induction of genes involved in the degradation of allantoin and glyoxylate by producing glyoxylate
C1_02737	155864.EDL933_0589	3.8e-173	614.0	Gammaproteobacteria	allS	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0043565,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141		ko:K10972					ko00000,ko03000				Bacteria	1P293@1224,1RNA3@1236,COG0583@1,COG0583@2	NA|NA|NA	K	Transcriptional regulator
C1_02738	481805.EcolC_3119	3.9e-209	733.8	Escherichia	selU	GO:0001887,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016785,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043828,GO:0044237,GO:0044238,GO:0046483,GO:0070329,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360		ko:K06917					ko00000,ko01000,ko03016				Bacteria	1N4T5@1224,1RPFP@1236,3XP1I@561,COG2603@1,COG2603@2	NA|NA|NA	J	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C1_02739	155864.EDL933_0587	1.4e-62	245.4	Gammaproteobacteria	ylbG												Bacteria	1MZ45@1224,1RSNX@1236,COG2801@1,COG2801@2	NA|NA|NA	L	COG2801 Transposase and inactivated derivatives
C1_02740	1005999.GLGR_1971	7.5e-11	73.9	Gammaproteobacteria													Bacteria	1P8A1@1224,1STFA@1236,2CJS5@1,2ZTHN@2	NA|NA|NA		
C1_02741	481805.EcolC_2201	0.0	2063.1	Escherichia	rhsD	GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010438,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042594,GO:0050896,GO:0051716,GO:0071496											Bacteria	1MVV1@1224,1SKYM@1236,3XQWR@561,COG3209@1,COG3209@2	NA|NA|NA	M	Rhs elements have a nonessential function. They may play an important role in the natural ecology of the cell
C1_02742	316407.85674635	0.0	1532.3	Escherichia	ybbP	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02004		M00258			ko00000,ko00002,ko02000	3.A.1			Bacteria	1MU9R@1224,1RM8Y@1236,3XMBI@561,COG3127@1,COG3127@2	NA|NA|NA	Q	FtsX-like permease family
C1_02743	155864.EDL933_0583	5.1e-122	443.7	Escherichia	ybbA	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K02003		M00258			ko00000,ko00002,ko02000	3.A.1			Bacteria	1MXG9@1224,1RMG1@1236,3XMIH@561,COG4181@1,COG4181@2	NA|NA|NA	P	ATP-binding protein YbbA
C1_02744	481805.EcolC_3122	1.8e-107	395.2	Escherichia	tesA	GO:0003674,GO:0003824,GO:0004620,GO:0004622,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016289,GO:0016290,GO:0016298,GO:0016787,GO:0016788,GO:0016790,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0047617,GO:0052689,GO:0071704,GO:0140096,GO:1901564	3.1.1.5	ko:K10804	ko01040,map01040				ko00000,ko00001,ko01000,ko01004			iECED1_1282.ECED1_0521,iLF82_1304.LF82_2242,iNRG857_1313.NRG857_02365	Bacteria	1RCXZ@1224,1S3QU@1236,3XMR2@561,COG2755@1,COG2755@2	NA|NA|NA	E	TesA is a multifunctional esterase that can act as a thioesterase, lysophospholipase and protease. TesA functions as a thioesterase specific for fatty acyl thioesters of greater than ten carbons, with highest activity on palmitoyl-CoA, cis-vaccenyl-CoA and palmitoleoyl-CoA. TesA also possesses an arylesterase activity towards short acyl-chain aromatic esters such as alpha-naphthyl acetate, alpha-naphthyl butyrate, benzyl acetate and phenyl acetate. Also able to hydrolyze short acyl-chain triacylglycerols such as triacetin and tributyrin, and p- nitrophenyl esters such as p-nitrophenyl hexanoate and p- nitrophenyl butyrate. The protease activity is mainly active on small peptides. TesA is also able to hydrolyze p-nitrophenyl esters of N- substituted amino acids such as N-benzyloxycarbonyl-L-Phe-p- nitrophenyl ester (Z-L-Phe-ONp) and N-benzyloxycarbonyl-L-Tyr-p- nitrophenyl ester (Z-L-Tyr-ONp), however it is unable to hydrolyze N-acetyl-L-Phe ethyl ester and its Tyr analog. TesA also hydrolyzes N- benzyloxycarbonyl-L-Phe beta-nitrophenyl ester (Cbz-Phe-ONap) and N-acetyl-DL-Phe-2-naphthyl ester (chymotrypsin-like specificity). Shows a slow proteolytic activity against denatured casein. The lysophospholipase activity of TesA is able to hydrolyze 1- palmitoyl-sn-glycero-3-phosphocholine, 1-acyl-sn-glycero-3- phosphoglycerol, 1- and 2-acyl-sn-glycero-3-phosphoethanolamine
C1_02745	469008.B21_00449	1.1e-141	509.2	Escherichia	ybbO	GO:0003674,GO:0003824,GO:0004033,GO:0008106,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0055114											Bacteria	1RGKZ@1224,1T1HV@1236,3XPHF@561,COG0300@1,COG0300@2	NA|NA|NA	S	alcohol dehydrogenase (NADP+) activity
C1_02746	155864.EDL933_0580	7.7e-152	543.1	Escherichia	ybbN	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0008150,GO:0008152,GO:0009987,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0061077		ko:K05838					ko00000,ko03110				Bacteria	1MV0R@1224,1RMSQ@1236,3XNYC@561,COG3118@1,COG3118@2	NA|NA|NA	O	protein disulfide oxidoreductase activity
C1_02747	155864.EDL933_0579	2.9e-129	468.0	Escherichia	ybbM	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0009987,GO:0015075,GO:0016020,GO:0016021,GO:0019725,GO:0022857,GO:0030003,GO:0031224,GO:0031226,GO:0034220,GO:0042592,GO:0044425,GO:0044459,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071944,GO:0098771		ko:K02069		M00211			ko00000,ko00002,ko02000	9.B.25.1			Bacteria	1MV2N@1224,1RSGA@1236,3XPB6@561,COG0390@1,COG0390@2	NA|NA|NA	S	Part of the ABC transporter complex FetAB, which is probably involved in iron export and enhances resistance to H(2)O(2)-mediated oxidative stress. Probably responsible for the translocation of the substrate across the membrane
C1_02748	316407.85674629	2.4e-124	451.4	Escherichia	ybbL	GO:0005575,GO:0005623,GO:0005886,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0009987,GO:0016020,GO:0019725,GO:0030003,GO:0042592,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071944,GO:0098771		ko:K02065,ko:K02068	ko02010,map02010	M00210,M00211,M00669,M00670			ko00000,ko00001,ko00002,ko02000	3.A.1.27			Bacteria	1NZKM@1224,1RQ94@1236,3XPEP@561,COG4619@1,COG4619@2	NA|NA|NA	P	Part of the ABC transporter complex FetAB, which is probably involved in iron export and enhances resistance to H(2)O(2)-mediated oxidative stress. Probably responsible for energy coupling to the transport system
C1_02749	155864.EDL933_0577	2.3e-125	455.3	Escherichia	qmcA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1MUM8@1224,1RNW8@1236,3XNCK@561,COG0330@1,COG0330@2	NA|NA|NA	O	Identified as a multi-copy suppressor of an FtsH HtpX protease double disruption mutant. May play a role in the quality control of integral membrane proteins
C1_02750	481805.EcolC_3128	3.2e-80	304.3	Escherichia	ybbJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K07340					ko00000				Bacteria	1N241@1224,1S5W4@1236,3XPSV@561,COG1585@1,COG1585@2	NA|NA|NA	OU	NfeD-like C-terminal, partner-binding
C1_02751	198214.SF0432	9.2e-71	272.7	Gammaproteobacteria	cueR	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0001130,GO:0001131,GO:0001199,GO:0001204,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0046872,GO:0046914,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070887,GO:0071241,GO:0071248,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141		ko:K19591		M00769			ko00000,ko00002,ko01504,ko03000				Bacteria	1RGX6@1224,1S8ZG@1236,COG0789@1,COG0789@2	NA|NA|NA	K	Transcriptional regulator
C1_02752	316407.85674625	1.3e-222	778.9	Escherichia	ybaT	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009268,GO:0009628,GO:0010035,GO:0010038,GO:0016020,GO:0042221,GO:0044464,GO:0046688,GO:0050896,GO:0071944,GO:0097501,GO:1990169		ko:K16263					ko00000,ko02000	2.A.3.13			Bacteria	1QVWZ@1224,1T2MA@1236,3XPI4@561,COG0531@1,COG0531@2	NA|NA|NA	E	transport protein
C1_02753	316407.85674624	1.2e-171	609.0	Escherichia	glsA	GO:0003674,GO:0003824,GO:0004359,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006543,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009065,GO:0009084,GO:0009268,GO:0009628,GO:0009987,GO:0010447,GO:0016043,GO:0016053,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0022607,GO:0040008,GO:0043436,GO:0043648,GO:0043650,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0045926,GO:0046394,GO:0046395,GO:0048519,GO:0050789,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	3.5.1.2	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230		R00256,R01579	RC00010,RC02798	ko00000,ko00001,ko01000			e_coli_core.b0485,iAF1260.b0485,iB21_1397.B21_00441,iBWG_1329.BWG_0366,iECBD_1354.ECBD_3171,iECB_1328.ECB_00436,iECDH10B_1368.ECDH10B_0442,iECDH1ME8569_1439.ECDH1ME8569_0469,iECD_1391.ECD_00436,iECO111_1330.ECO111_0520,iETEC_1333.ETEC_0537,iEcDH1_1363.EcDH1_3125,iJO1366.b0485,iJR904.b0485,iUMNK88_1353.UMNK88_538,iY75_1357.Y75_RS02500	Bacteria	1MWB5@1224,1RMY9@1236,3XMCV@561,COG2066@1,COG2066@2	NA|NA|NA	E	Belongs to the glutaminase family
C1_02754	316407.85674623	0.0	1557.3	Escherichia	copA	GO:0000041,GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0006950,GO:0008150,GO:0008324,GO:0009636,GO:0009987,GO:0010035,GO:0010038,GO:0010272,GO:0010273,GO:0015075,GO:0015080,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0035434,GO:0042221,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046688,GO:0046873,GO:0046915,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0060003,GO:0061687,GO:0070887,GO:0071241,GO:0071248,GO:0071280,GO:0071292,GO:0071944,GO:0090662,GO:0097501,GO:0098655,GO:0098660,GO:0098662,GO:0098754,GO:0099131,GO:1902601,GO:1990169	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016		R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5		iEC55989_1330.EC55989_0497,iECIAI1_1343.ECIAI1_0487,iECO103_1326.ECO103_0460,iECSE_1348.ECSE_0509,iECW_1372.ECW_m0557,iEKO11_1354.EKO11_3363,iWFL_1372.ECW_m0557	Bacteria	1MU08@1224,1RN2C@1236,3XNB5@561,COG2217@1,COG2217@2	NA|NA|NA	P	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily
C1_02755	637910.ROD_00481	9.4e-162	576.2	Gammaproteobacteria	piv			ko:K07486					ko00000				Bacteria	1MXKJ@1224,1RSCP@1236,COG3547@1,COG3547@2	NA|NA|NA	L	Transposase
C1_02756	198214.SF0428	1.1e-63	249.2	Gammaproteobacteria	ybaQ	GO:0008150,GO:0009636,GO:0042221,GO:0050896		ko:K21498					ko00000,ko02048				Bacteria	1N76J@1224,1S83W@1236,COG3093@1,COG3093@2	NA|NA|NA	K	addiction module antidote protein, HigA family
C1_02757	316407.85674621	3.3e-149	534.3	Escherichia	ybaP			ko:K09973					ko00000				Bacteria	1MVCW@1224,1RRI8@1236,3XN0U@561,COG3735@1,COG3735@2	NA|NA|NA	S	TraB family
C1_02758	198214.SF0426	3.6e-82	310.8	Gammaproteobacteria	ybaK	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0043906,GO:0043907,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360		ko:K03976,ko:K19055					ko00000,ko01000,ko03016				Bacteria	1RGX5@1224,1S6S0@1236,COG2606@1,COG2606@2	NA|NA|NA	S	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C1_02759	316407.85674619	0.0	1109.4	Escherichia	ushA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006139,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008768,GO:0009225,GO:0009987,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0030288,GO:0030313,GO:0031975,GO:0034641,GO:0042578,GO:0042597,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:1901135,GO:1901360	3.1.3.5,3.6.1.45	ko:K11751	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110		R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000			iEC55989_1330.EC55989_0493,iECIAI1_1343.ECIAI1_0483,iECO103_1326.ECO103_0456,iECSE_1348.ECSE_0505	Bacteria	1MX03@1224,1RPX3@1236,3XM6V@561,COG0737@1,COG0737@2	NA|NA|NA	F	Belongs to the 5'-nucleotidase family
C1_02760	316407.85674618	3.7e-216	757.3	Escherichia	fsr	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0033554,GO:0042221,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071944		ko:K08223					ko00000,ko02000	2.A.1.35			Bacteria	1MXAA@1224,1RMZZ@1236,3XP1S@561,COG2223@1,COG2223@2	NA|NA|NA	P	Fosmidomycin resistance protein
C1_02761	155864.EDL933_0554	3.3e-292	1010.4	Escherichia	ybaL	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03455					ko00000	2.A.37			Bacteria	1MV34@1224,1RMM7@1236,3XM64@561,COG1226@1,COG1226@2,COG4651@1,COG4651@2	NA|NA|NA	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
C1_02762	155864.EDL933_0553	1.5e-255	888.3	Escherichia	gsk	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008906,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237	2.7.1.20,2.7.1.73,2.7.1.92	ko:K00856,ko:K00892,ko:K03338	ko00230,ko00562,ko01100,ko01120,map00230,map00562,map01100,map01120		R00185,R01131,R01228,R05661	RC00002,RC00017	ko00000,ko00001,ko01000			iSDY_1059.SDY_0442	Bacteria	1MUUC@1224,1RMN2@1236,3XMG2@561,COG0524@1,COG0524@2	NA|NA|NA	F	inosine kinase activity
C1_02763	316407.85674615	1.1e-186	659.1	Escherichia	aes	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008126,GO:0008150,GO:0008152,GO:0009056,GO:0009889,GO:0010468,GO:0010556,GO:0016787,GO:0016788,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0034338,GO:0043086,GO:0043433,GO:0044092,GO:0044424,GO:0044464,GO:0048519,GO:0050789,GO:0050790,GO:0050794,GO:0051090,GO:0051171,GO:0051252,GO:0051336,GO:0051346,GO:0052689,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:1903506,GO:2000112,GO:2001141		ko:K01066					ko00000,ko01000				Bacteria	1NEXK@1224,1RY94@1236,3XPGA@561,COG0657@1,COG0657@2	NA|NA|NA	I	Displays esterase activity towards short chain fatty esters (acyl chain length of up to 8 carbons). Able to hydrolyze triacetylglycerol (triacetin) and tributyrylglycerol (tributyrin), but not trioleylglycerol (triolein) or cholesterol oleate. Negatively regulates MalT activity by antagonizing maltotriose binding. Inhibits MelA galactosidase activity
C1_02764	198214.SF0420	8.5e-184	649.4	Gammaproteobacteria	hemH	GO:0003674,GO:0003824,GO:0004325,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009314,GO:0009416,GO:0009628,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_1540,iECS88_1305.ECS88_0472,iEcE24377_1341.EcE24377A_0515	Bacteria	1MVR1@1224,1RMMS@1236,COG0276@1,COG0276@2	NA|NA|NA	H	Catalyzes the ferrous insertion into protoporphyrin IX
C1_02765	155864.EDL933_0550	3e-116	424.5	Escherichia	adk	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004017,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006172,GO:0006412,GO:0006518,GO:0006629,GO:0006644,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009133,GO:0009135,GO:0009136,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009179,GO:0009180,GO:0009185,GO:0009188,GO:0009259,GO:0009260,GO:0009987,GO:0010467,GO:0015949,GO:0015950,GO:0015951,GO:0016070,GO:0016208,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019205,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046390,GO:0046483,GO:0046872,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147			iECH74115_1262.ECH74115_0566,iEKO11_1354.EKO11_3373,iG2583_1286.G2583_0586	Bacteria	1MXCZ@1224,1RMT6@1236,3XP7G@561,COG0563@1,COG0563@2	NA|NA|NA	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
C1_02766	155864.EDL933_0548	0.0	1228.4	Escherichia	htpG	GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010035,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0042623,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0070887,GO:0071450,GO:0071451,GO:0071944,GO:1901700,GO:1901701		ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418				ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147				Bacteria	1MUUE@1224,1RNWD@1236,3XNBQ@561,COG0326@1,COG0326@2	NA|NA|NA	O	Molecular chaperone. Has ATPase activity
C1_02767	155864.EDL933_0547	8.7e-110	402.9	Escherichia	recR	GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576		ko:K06187	ko03440,map03440				ko00000,ko00001,ko03400				Bacteria	1MV9Q@1224,1RN99@1236,3XM8A@561,COG0353@1,COG0353@2	NA|NA|NA	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C1_02768	1005994.GTGU_01283	3e-48	197.6	Gammaproteobacteria	ybaB	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:1901363		ko:K06187,ko:K09747	ko03440,map03440				ko00000,ko00001,ko03400				Bacteria	1RGZD@1224,1S5WU@1236,COG0718@1,COG0718@2	NA|NA|NA	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C1_02769	199310.c0589	0.0	1211.8	Escherichia	dnaX	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0042575,GO:0042802,GO:0043170,GO:0043846,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050790,GO:0061695,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Bacteria	1MVCK@1224,1RMIA@1236,3XNC3@561,COG2812@1,COG2812@2	NA|NA|NA	F	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits
C1_02770	199310.c0588	1.6e-97	362.1	Escherichia	apt	GO:0000287,GO:0003674,GO:0003824,GO:0003999,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006166,GO:0006168,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042440,GO:0042451,GO:0042455,GO:0042802,GO:0043094,GO:0043096,GO:0043101,GO:0043167,GO:0043169,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046083,GO:0046084,GO:0046112,GO:0046128,GO:0046129,GO:0046148,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100		R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147			iUTI89_1310.UTI89_C0496,ic_1306.c0588	Bacteria	1MVZ6@1224,1S2N9@1236,3XNWM@561,COG0503@1,COG0503@2	NA|NA|NA	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C1_02771	155864.EDL933_0543	1.1e-62	245.7	Escherichia	ybaN	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K09790					ko00000				Bacteria	1N7BI@1224,1SCJZ@1236,3XPP0@561,COG2832@1,COG2832@2	NA|NA|NA	S	membrane
C1_02772	316407.85674606	4.8e-88	330.5	Escherichia	priC	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576		ko:K04067	ko03440,map03440				ko00000,ko00001,ko03400				Bacteria	1RIA6@1224,1S5VE@1236,3XMRC@561,COG3923@1,COG3923@2	NA|NA|NA	L	Primosomal replication protein N'
C1_02773	199310.c0585	9.3e-19	98.6	Escherichia	ybaM	GO:0006950,GO:0008150,GO:0009987,GO:0033554,GO:0036460,GO:0050896,GO:0051716											Bacteria	1NGAT@1224,1SGE4@1236,2EHYU@1,33BQB@2,3XQ3N@561	NA|NA|NA	S	cellular response to cell envelope stress
C1_02774	198214.SF0410	0.0	2090.5	Gammaproteobacteria	kefA	GO:0005575,GO:0005623,GO:0005886,GO:0006884,GO:0008150,GO:0008361,GO:0009987,GO:0009992,GO:0016020,GO:0016043,GO:0019725,GO:0030104,GO:0032535,GO:0042592,GO:0044464,GO:0048878,GO:0055082,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066		ko:K05802,ko:K06994,ko:K15771,ko:K22051	ko02010,map02010	M00491			ko00000,ko00001,ko00002,ko02000	1.A.23.1.1,1.A.23.1.2,1.A.23.1.3,3.A.1.1.16,3.A.1.1.2			Bacteria	1MWSA@1224,1RMYY@1236,COG1196@1,COG1196@2,COG3264@1,COG3264@2	NA|NA|NA	M	mechanosensitive ion channel
C1_02775	198214.SF0409	6e-117	426.8	Gammaproteobacteria	acrR	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042493,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K03577		M00647			ko00000,ko00002,ko03000				Bacteria	1N659@1224,1RPXN@1236,COG1309@1,COG1309@2	NA|NA|NA	K	transcriptional regulator
C1_02776	316407.85674602	2.6e-214	751.1	Escherichia	acrA	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0006869,GO:0008150,GO:0010876,GO:0015238,GO:0015711,GO:0015718,GO:0015721,GO:0015849,GO:0015850,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0032991,GO:0033036,GO:0042221,GO:0042493,GO:0042597,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098796,GO:1902495,GO:1990281,GO:1990351		ko:K03585,ko:K18141,ko:K18898	ko01501,ko01503,map01501,map01503	M00646,M00647,M00696,M00697,M00699,M00718			ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1,8.A.1.6,8.A.1.6.3		iSDY_1059.SDY_0456	Bacteria	1MU78@1224,1RPI1@1236,3XM5Z@561,COG0845@1,COG0845@2	NA|NA|NA	M	AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an adapter protein that links AcrB and TolC stably together
C1_02777	316407.85674601	0.0	1988.4	Escherichia	acrB	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006855,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015238,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015307,GO:0015318,GO:0015672,GO:0015893,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0042221,GO:0042493,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0046618,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1902495,GO:1902600,GO:1990281,GO:1990351		ko:K18138,ko:K18142,ko:K18899	ko01501,ko01503,map01501,map01503	M00647,M00696,M00697,M00699,M00718			ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2,2.A.6.2.13		iAF1260.b3266,iJO1366.b3266	Bacteria	1MU48@1224,1RMBN@1236,3XP4C@561,COG0841@1,COG0841@2	NA|NA|NA	V	efflux pump
C1_02778	155864.EDL933_0536	1.3e-68	265.4	Escherichia	tomB	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0008150,GO:0009987,GO:0042710,GO:0044010,GO:0044764,GO:0051704,GO:0097159,GO:1901363		ko:K19162					ko00000,ko02048				Bacteria	1RA3M@1224,1S20M@1236,28PF7@1,2ZC6G@2,3XPMI@561	NA|NA|NA	L	Attenuates Hha toxicity and regulates biofilm formation. Binds to various coding and intergenic regions of genomic DNA
C1_02779	1115512.EH105704_01_09350	2.4e-33	147.5	Escherichia	hha	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0010468,GO:0019222,GO:0032879,GO:0040012,GO:0040017,GO:0043900,GO:0043901,GO:0044424,GO:0044444,GO:0044464,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051270,GO:0051272,GO:0060255,GO:0065007,GO:1900190,GO:1900191,GO:2000145,GO:2000147		ko:K05839					ko00000,ko02048				Bacteria	1MZDE@1224,1S995@1236,2CN5N@1,32SGA@2,3XPZ9@561	NA|NA|NA	K	Hha and Cnu (YdgT) increase the number of genes DNA bound by H-NS StpA and may also modulate the oligomerization of the H-NS StpA-complex. Binds DNA and influences DNA topology in response to environmental stimuli
C1_02780	316407.85674598	4.9e-91	340.5	Escherichia	maa	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008374,GO:0008870,GO:0008925,GO:0009987,GO:0016043,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0022607,GO:0042802,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071840	2.3.1.18,2.3.1.79	ko:K00633,ko:K00661					ko00000,ko01000			iAPECO1_1312.APECO1_15532,iECOK1_1307.ECOK1_0441,iECS88_1305.ECS88_0456,iUMN146_1321.UM146_15065,iUTI89_1310.UTI89_C0486	Bacteria	1RA2T@1224,1S3ZZ@1236,3XNX0@561,COG0110@1,COG0110@2	NA|NA|NA	S	Maltose O-acetyltransferase
C1_02781	155864.EDL933_0533	5.1e-81	307.0	Escherichia	ylaC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1RIZ1@1224,1S7K3@1236,2CEAX@1,328KF@2,3XPGN@561	NA|NA|NA	S	Inner membrane protein YlaC
C1_02782	469008.B21_00412	7.6e-299	1032.3	Escherichia	ylaB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008081,GO:0016020,GO:0016787,GO:0016788,GO:0042578,GO:0044464,GO:0071111,GO:0071944	3.1.4.52	ko:K21090	ko02026,map02026				ko00000,ko00001,ko01000				Bacteria	1MVTH@1224,1RMDP@1236,3XP29@561,COG4943@1,COG4943@2	NA|NA|NA	T	May function as a c-di-GMP phosphodiesterase. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria (By similarity)
C1_02783	155864.EDL933_0531	1.7e-60	238.4	Escherichia	ybaA												Bacteria	1RHC1@1224,1S6KT@1236,3XPSZ@561,COG5507@1,COG5507@2	NA|NA|NA	S	Protein of unknown function (DUF1428)
C1_02784	155864.EDL933_0530	6.6e-53	213.0	Escherichia	ybaZ	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0005488,GO:0005515,GO:0019899,GO:0097159,GO:1901363	2.1.1.63	ko:K00567,ko:K07443					ko00000,ko01000,ko03400				Bacteria	1N7J2@1224,1SCIZ@1236,3XPUB@561,COG3695@1,COG3695@2	NA|NA|NA	L	Involved in DNA damage recognition. Binds DNA containing O(6)-methylguanine and larger O(6)-alkylguanine adducts, and to double-stranded DNA that contains an AP (apurinic apyrimidinic) site. Binds to the damaged base and flips the base out of the DNA duplex into an extrahelical conformation, which allows processing by repair proteins. Works in partnership with the nucleotide excision repair (NER) pathway to enhance the repair of the O(6)-alkylguanine adducts larger than the methyl adduct. Also prevents methyl-directed mismatch repair (MMR)-mediated attack of the O(6)-alkylguanine T mispairs for the larger alkyl groups
C1_02785	469008.B21_00409	4.1e-93	347.4	Escherichia	ybaY			ko:K09914					ko00000				Bacteria	1N8AF@1224,1SCM7@1236,3XNRM@561,COG3126@1,COG3126@2	NA|NA|NA	S	Type III secretion system lipoprotein chaperone (YscW)
C1_02786	155864.EDL933_0527	2.2e-162	578.2	Escherichia	tesB	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016042,GO:0016054,GO:0016289,GO:0016787,GO:0016788,GO:0016790,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042802,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046483,GO:0047617,GO:0051186,GO:0055086,GO:0071704,GO:0072329,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901575		ko:K10805	ko01040,map01040				ko00000,ko00001,ko01000,ko01004			iAF1260.b0452,iB21_1397.B21_00408,iBWG_1329.BWG_0334,iEC55989_1330.EC55989_0466,iECBD_1354.ECBD_3203,iECB_1328.ECB_00404,iECDH10B_1368.ECDH10B_0408,iECDH1ME8569_1439.ECDH1ME8569_0437,iECD_1391.ECD_00404,iECH74115_1262.ECH74115_0541,iECIAI1_1343.ECIAI1_0456,iECIAI39_1322.ECIAI39_0221,iECO103_1326.ECO103_0429,iECO111_1330.ECO111_0485,iECO26_1355.ECO26_0487,iECSE_1348.ECSE_0478,iECSP_1301.ECSP_0520,iECUMN_1333.ECUMN_0492,iECW_1372.ECW_m0524,iECs_1301.ECs0506,iEKO11_1354.EKO11_3394,iETEC_1333.ETEC_0505,iEcDH1_1363.EcDH1_3157,iEcE24377_1341.EcE24377A_0488,iEcHS_1320.EcHS_A0529,iEcSMS35_1347.EcSMS35_0496,iEcolC_1368.EcolC_3163,iG2583_1286.G2583_0564,iJO1366.b0452,iSSON_1240.SSON_0440,iUMNK88_1353.UMNK88_505,iWFL_1372.ECW_m0524,iY75_1357.Y75_RS02335,iZ_1308.Z0564,ic_1306.c0571	Bacteria	1MV9R@1224,1RPFI@1236,3XMKC@561,COG1946@1,COG1946@2	NA|NA|NA	I	acyl-CoA thioesterase II
C1_02787	155864.EDL933_0526	7.8e-233	812.8	Escherichia	amtB	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0008519,GO:0015075,GO:0015291,GO:0015292,GO:0015669,GO:0015670,GO:0015696,GO:0015893,GO:0016020,GO:0016021,GO:0019755,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072488,GO:0098655		ko:K03320					ko00000,ko02000	1.A.11		iEcE24377_1341.EcE24377A_0487	Bacteria	1NR9F@1224,1RNKF@1236,3XP3W@561,COG0004@1,COG0004@2	NA|NA|NA	P	transporter
C1_02788	1440052.EAKF1_ch0982c	9.3e-53	212.6	Escherichia	glnK	GO:0003674,GO:0005488,GO:0005515,GO:0006808,GO:0008150,GO:0042802,GO:0045848,GO:0048518,GO:0050789,GO:0065007		ko:K04751,ko:K04752	ko02020,map02020				ko00000,ko00001				Bacteria	1RGWK@1224,1S67I@1236,3XPRC@561,COG0347@1,COG0347@2	NA|NA|NA	K	Nitrogen regulatory protein P-II
C1_02789	469008.B21_00405	0.0	1104.0	Escherichia	mdlB	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008144,GO:0008150,GO:0010876,GO:0015399,GO:0015405,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0031224,GO:0032553,GO:0032555,GO:0032559,GO:0033036,GO:0034040,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043492,GO:0044425,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K06147,ko:K18890	ko02010,map02010	M00707			ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21			Bacteria	1MUBM@1224,1RMUR@1236,3XP6P@561,COG1132@1,COG1132@2	NA|NA|NA	P	xenobiotic transmembrane transporting ATPase activity
C1_02790	469008.B21_00404	0.0	1129.0	Escherichia	mdlA	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0016021,GO:0017076,GO:0030554,GO:0031224,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044425,GO:0044464,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K06148,ko:K18889	ko02010,map02010	M00707			ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.106.13,3.A.1.106.5			Bacteria	1MUBM@1224,1RMUR@1236,3XMIE@561,COG1132@1,COG1132@2	NA|NA|NA	P	ATP-binding
C1_02791	155864.EDL933_0521	4.2e-80	303.9	Escherichia	ybaO	GO:0000096,GO:0000098,GO:0001101,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006351,GO:0006355,GO:0006520,GO:0006534,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009063,GO:0009069,GO:0009071,GO:0009093,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010033,GO:0010243,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016054,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0043170,GO:0043200,GO:0043254,GO:0043436,GO:0043565,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0044273,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046395,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901698,GO:1901700,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2000142,GO:2000144,GO:2001141		ko:K03719,ko:K05800					ko00000,ko03000,ko03036				Bacteria	1RDB3@1224,1S2E1@1236,3XPDQ@561,COG1522@1,COG1522@2	NA|NA|NA	K	Plays a role in L-cysteine detoxification. Binds to the dlsT(yhaO)-yhaM operon promoter in the presence but not absence of L-cysteine
C1_02792	362663.ECP_0507	1.2e-159	568.9	Escherichia	cof	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0016999,GO:0017001,GO:0017110,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042578,GO:0042723,GO:0042724,GO:0043167,GO:0043169,GO:0044237,GO:0044248,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0046872,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576		ko:K11938					ko00000,ko01000			iB21_1397.B21_00402,iE2348C_1286.E2348C_0381,iEC55989_1330.EC55989_0460,iECBD_1354.ECBD_3209,iECB_1328.ECB_00398,iECD_1391.ECD_00398,iECIAI39_1322.ECIAI39_0227,iECNA114_1301.ECNA114_0424,iECO103_1326.ECO103_0423,iECO111_1330.ECO111_0479,iECO26_1355.ECO26_0481,iECOK1_1307.ECOK1_0428,iECP_1309.ECP_0507,iECS88_1305.ECS88_0443,iECSE_1348.ECSE_0472,iECW_1372.ECW_m0518,iETEC_1333.ETEC_0499,iEcE24377_1341.EcE24377A_0482,iEcHS_1320.EcHS_A0523,iEcSMS35_1347.EcSMS35_0489,iLF82_1304.LF82_0340,iNRG857_1313.NRG857_02110,iSbBS512_1146.SbBS512_E0369,iUMNK88_1353.UMNK88_498,iUTI89_1310.UTI89_C4390,iWFL_1372.ECW_m0518	Bacteria	1MXAF@1224,1RQXF@1236,3XMPP@561,COG0561@1,COG0561@2	NA|NA|NA	S	Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P)
C1_02793	469008.B21_00401	0.0	1174.5	Escherichia	ybaE	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464											Bacteria	1PIAC@1224,1RPRW@1236,3XMBF@561,COG4533@1,COG4533@2	NA|NA|NA	S	Sugar transport-related sRNA regulator N-term
C1_02794	198214.SF0389	3.6e-131	474.2	Gammaproteobacteria	queC		6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100		R09978	RC00959	ko00000,ko00001,ko01000,ko03016				Bacteria	1MU5V@1224,1RMG9@1236,COG0603@1,COG0603@2	NA|NA|NA	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C1_02795	316407.85674583	1.5e-65	255.4	Escherichia	tesC	GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016289,GO:0016787,GO:0016788,GO:0016790,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0047617,GO:0055114,GO:0071704,GO:0072329,GO:1901575		ko:K07107,ko:K12500					ko00000,ko01000,ko01004			iSDY_1059.SDY_0684	Bacteria	1REIH@1224,1S40Z@1236,3XPNH@561,COG0824@1,COG0824@2	NA|NA|NA	S	acyl-CoA hydrolase activity
C1_02796	198214.SF0387	4.9e-55	220.3	Gammaproteobacteria	ybaV	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464	3.1.26.11	ko:K00784,ko:K02237	ko03013,map03013	M00429			ko00000,ko00001,ko00002,ko01000,ko02044,ko03016	3.A.11.1,3.A.11.2			Bacteria	1N6Q3@1224,1SC7U@1236,COG1555@1,COG1555@2	NA|NA|NA	L	Competence protein ComEA
C1_02797	199310.c0557	0.0	1097.8	Escherichia	ppiD	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0008150,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031233,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0061077,GO:0071575,GO:0071944,GO:0098552	5.2.1.8	ko:K01802,ko:K03769,ko:K03770					ko00000,ko01000,ko03110				Bacteria	1MWV0@1224,1RMT5@1236,3XNHD@561,COG0760@1,COG0760@2	NA|NA|NA	O	PPIases accelerate the folding of proteins. Seems to be involved in the folding of outer membrane proteins
C1_02798	1440052.EAKF1_ch0992c	4.7e-39	166.8	Escherichia	hupB	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0005737,GO:0005829,GO:0006139,GO:0006323,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010556,GO:0016043,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0051276,GO:0060255,GO:0065007,GO:0071103,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2001141		ko:K03530					ko00000,ko03032,ko03036,ko03400				Bacteria	1MZ5B@1224,1S8VH@1236,3XPX1@561,COG0776@1,COG0776@2	NA|NA|NA	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
C1_02799	199310.c0555	0.0	1511.1	Escherichia	lon	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004175,GO:0004176,GO:0004252,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009408,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0017171,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051603,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	3.4.21.53	ko:K01338	ko04112,map04112				ko00000,ko00001,ko01000,ko01002				Bacteria	1MUV2@1224,1RPCB@1236,3XNIW@561,COG0466@1,COG0466@2	NA|NA|NA	O	Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C1_02800	155864.EDL933_0510	1.9e-239	834.7	Escherichia	clpX	GO:0000166,GO:0000502,GO:0002020,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009376,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019899,GO:0019904,GO:0030163,GO:0030164,GO:0030312,GO:0030554,GO:0031333,GO:0031597,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0043335,GO:0044087,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0051704,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0097718,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369		ko:K03544	ko04112,map04112				ko00000,ko00001,ko03110				Bacteria	1MVQK@1224,1RN9N@1236,3XM4E@561,COG1219@1,COG1219@2	NA|NA|NA	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C1_02801	155864.EDL933_0509	8.7e-113	412.9	Escherichia	clpP	GO:0000502,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0010498,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017171,GO:0019538,GO:0019899,GO:0030163,GO:0031597,GO:0032991,GO:0042623,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0050896,GO:0051117,GO:0051603,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212				ko00000,ko00001,ko01000,ko01002				Bacteria	1MV46@1224,1RNR6@1236,3XN6V@561,COG0740@1,COG0740@2	NA|NA|NA	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
C1_02802	155864.EDL933_0508	1.3e-232	812.0	Escherichia	tig	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006464,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0042802,GO:0043021,GO:0043022,GO:0043170,GO:0043335,GO:0043412,GO:0044183,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0050896,GO:0051083,GO:0061077,GO:0071704,GO:0140096,GO:1901564		ko:K03545					ko00000				Bacteria	1MUJP@1224,1RNZE@1236,3XM6A@561,COG0544@1,COG0544@2	NA|NA|NA	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
C1_02803	155864.EDL933_0506	1.5e-52	211.8	Escherichia	bolA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0019538,GO:0022603,GO:0022604,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051604,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097428,GO:0097659,GO:0106035,GO:1901360,GO:1901362,GO:1901564,GO:1901576		ko:K05527,ko:K22066					ko00000,ko03000,ko03029				Bacteria	1MZG5@1224,1S91G@1236,3XPVA@561,COG0271@1,COG0271@2	NA|NA|NA	K	Transcriptional regulator that plays an important role in general stress response. Has many effects on cell morphology, cell growth and cell division. Acts by regulating the transcription of many genes, including dacA (PBP-5), dacC (PBP-6), ampC and mreB. Probably involved in the coordination of genes that adapt the cell physiology in order to enhance cell adaptation and survival under stress conditions. Essential for normal cell morphology in stationary phase and under conditions of starvation. Also regulates a complex network of genes encoding proteins related to biofilm development, and negatively modulates flagellar biosynthesis and swimming capacity. Could be a motile adhesive transcriptional switch, specifically involved in the transition between the planktonic and the attachment stage of biofilm formation. Overexpression produces round cell shape, impairs cell growth rate and induces biofilm development
C1_02804	199310.c0546	1.9e-98	365.2	Escherichia	yajG			ko:K07286					ko00000				Bacteria	1MZ1N@1224,1RPG1@1236,3XNA8@561,COG3056@1,COG3056@2	NA|NA|NA	M	Uncharacterized lipoprotein
C1_02805	198214.SF0377	8e-274	949.1	Gammaproteobacteria	ampG	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K08218,ko:K08223	ko01501,map01501	M00628			ko00000,ko00001,ko00002,ko02000	2.A.1.25,2.A.1.35		iAPECO1_1312.APECO1_1578,iECOK1_1307.ECOK1_0413,iECS88_1305.ECS88_0429,iLF82_1304.LF82_0088,iNRG857_1313.NRG857_02040,iPC815.YPO3162,iUMN146_1321.UM146_15195,iUTI89_1310.UTI89_C0457	Bacteria	1QU4X@1224,1T1ST@1236,COG2223@1,COG2223@2	NA|NA|NA	P	Major facilitator superfamily
C1_02806	469008.B21_00387	3.1e-178	630.9	Escherichia	cyoA	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009055,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009486,GO:0009897,GO:0009986,GO:0009987,GO:0015002,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015453,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016310,GO:0016491,GO:0016679,GO:0016682,GO:0017144,GO:0019637,GO:0019646,GO:0019693,GO:0022804,GO:0022857,GO:0022890,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0031233,GO:0032991,GO:0034220,GO:0034641,GO:0042773,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0048037,GO:0048038,GO:0048039,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0055114,GO:0070069,GO:0071575,GO:0071704,GO:0071944,GO:0072521,GO:0098552,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1902600	1.10.3.10,1.10.3.12	ko:K02297,ko:K02826	ko00190,ko01100,map00190,map01100	M00416,M00417	R09492,R11335	RC00061,RC00819	ko00000,ko00001,ko00002,ko01000	3.D.4.1,3.D.4.5		iE2348C_1286.E2348C_0367,iJN746.PP_0812,iSB619.SA_RS05175	Bacteria	1MWHZ@1224,1RP4H@1236,3XMMP@561,COG1622@1,COG1622@2	NA|NA|NA	C	Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons electron
C1_02807	155864.EDL933_0501	0.0	1333.2	Escherichia	cyoB	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005507,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009055,GO:0009060,GO:0009319,GO:0009486,GO:0009987,GO:0015002,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015453,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016491,GO:0019646,GO:0020037,GO:0022804,GO:0022857,GO:0022890,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0043167,GO:0043169,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0048038,GO:0048039,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0070069,GO:0071944,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901363,GO:1902494,GO:1902600	1.10.3.10,1.10.3.12,1.9.3.1	ko:K02274,ko:K02298,ko:K02827	ko00190,ko01100,map00190,map01100	M00155,M00416,M00417	R00081,R09492,R11335	RC00016,RC00061,RC00819	ko00000,ko00001,ko00002,ko01000	3.D.4.1,3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.5,3.D.4.6			Bacteria	1MU7S@1224,1RPC3@1236,3XNDN@561,COG0843@1,COG0843@2	NA|NA|NA	C	Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons electron
C1_02808	198214.SF0371	2.5e-112	411.4	Gammaproteobacteria	cyoC	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009055,GO:0009060,GO:0009319,GO:0009486,GO:0009987,GO:0015002,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015453,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016491,GO:0019646,GO:0022804,GO:0022857,GO:0022890,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0070069,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1902494,GO:1902600		ko:K02299	ko00190,ko01100,map00190,map01100	M00417			ko00000,ko00001,ko00002	3.D.4.5		iPC815.YPO3166	Bacteria	1MUCK@1224,1RN9D@1236,COG1845@1,COG1845@2	NA|NA|NA	C	oxidase subunit
C1_02809	198214.SF0370	2.6e-52	211.1	Gammaproteobacteria	cyoD	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009055,GO:0009060,GO:0009319,GO:0009486,GO:0009987,GO:0015002,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015453,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016491,GO:0019646,GO:0022804,GO:0022857,GO:0022890,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0070069,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1902494,GO:1902600		ko:K02300	ko00190,ko01100,map00190,map01100	M00417			ko00000,ko00001,ko00002	3.D.4.5		iAF1260.b0429,iB21_1397.B21_00384,iBWG_1329.BWG_0311,iE2348C_1286.E2348C_0364,iEC042_1314.EC042_0467,iEC55989_1330.EC55989_0443,iECBD_1354.ECBD_3229,iECB_1328.ECB_00380,iECDH10B_1368.ECDH10B_0385,iECDH1ME8569_1439.ECDH1ME8569_0414,iECD_1391.ECD_00380,iECED1_1282.ECED1_0452,iECH74115_1262.ECH74115_0513,iECIAI1_1343.ECIAI1_0432,iECIAI39_1322.ECIAI39_0244,iECO103_1326.ECO103_0406,iECO111_1330.ECO111_0462,iECO26_1355.ECO26_0464,iECOK1_1307.ECOK1_0409,iECP_1309.ECP_0489,iECS88_1305.ECS88_0425,iECSE_1348.ECSE_0454,iECSF_1327.ECSF_0389,iECSP_1301.ECSP_0497,iECUMN_1333.ECUMN_0468,iECW_1372.ECW_m0501,iECs_1301.ECs0483,iEKO11_1354.EKO11_3417,iEcDH1_1363.EcDH1_3180,iEcE24377_1341.EcE24377A_0464,iEcHS_1320.EcHS_A0504,iEcSMS35_1347.EcSMS35_0469,iEcolC_1368.EcolC_3204,iG2583_1286.G2583_0541,iJO1366.b0429,iJR904.b0429,iLF82_1304.LF82_0407,iNRG857_1313.NRG857_02020,iSBO_1134.SBO_0323,iSSON_1240.SSON_0412,iUMN146_1321.UM146_15215,iUMNK88_1353.UMNK88_479,iUTI89_1310.UTI89_C0452,iWFL_1372.ECW_m0501,iY75_1357.Y75_RS02215,iYL1228.KPN_00391,iZ_1308.Z0532	Bacteria	1RHE5@1224,1S6KQ@1236,COG3125@1,COG3125@2	NA|NA|NA	C	cytochrome o ubiquinol oxidase
C1_02810	199310.c0539	3.6e-160	570.9	Escherichia	cyoE	GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008495,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0048033,GO:0048034,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029			iSFxv_1172.SFxv_0410,iYO844.BSU12080	Bacteria	1MW3S@1224,1RNHC@1236,3XNIU@561,COG0109@1,COG0109@2	NA|NA|NA	H	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group
C1_02811	469008.B21_00382	1.4e-47	195.3	Gammaproteobacteria													Bacteria	1NNVM@1224,1SGP5@1236,2DTRR@1,33ME8@2	NA|NA|NA	S	Protein of unknown function (DUF1778)
C1_02812	469008.B21_00381	3.4e-97	360.9	Gammaproteobacteria													Bacteria	1NY59@1224,1SQRQ@1236,COG0454@1,COG0454@2	NA|NA|NA	K	Acetyltransferase (GNAT) domain
C1_02813	469008.B21_00380	1.9e-146	525.4	Gammaproteobacteria				ko:K07126					ko00000				Bacteria	1MYIN@1224,1S6J7@1236,COG0790@1,COG0790@2	NA|NA|NA	S	Sel1-like repeats.
C1_02814	469008.B21_00379	4.5e-247	860.1	Escherichia	yajR	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944											Bacteria	1MVSH@1224,1RN70@1236,3XMNI@561,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
C1_02815	1440052.EAKF1_ch1011c	3.1e-81	307.8	Escherichia	yajQ	GO:0000049,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0009987,GO:0017076,GO:0019001,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033554,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K09767					ko00000				Bacteria	1RDTF@1224,1S3RU@1236,3XN7B@561,COG1666@1,COG1666@2	NA|NA|NA	S	UPF0234 protein YajQ
C1_02816	198214.SF0362	7.6e-174	616.3	Gammaproteobacteria	panE	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008677,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0036094,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000			iYO844.BSU15110	Bacteria	1P0AW@1224,1RR49@1236,COG1893@1,COG1893@2	NA|NA|NA	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C1_02817	199310.c0535	1.8e-104	385.2	Escherichia	thiJ	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006464,GO:0006517,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009100,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0019538,GO:0022613,GO:0030091,GO:0033554,GO:0034599,GO:0036211,GO:0036524,GO:0036525,GO:0042026,GO:0042221,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0070887,GO:0071704,GO:0071840,GO:0140096,GO:1901135,GO:1901564	2.7.11.1,3.5.1.124,4.2.1.130	ko:K03152,ko:K05520,ko:K05523,ko:K05687,ko:K12132	ko00620,ko01120,ko05012,map00620,map01120,map05012		R09796	RC02658	ko00000,ko00001,ko01000,ko01001,ko01002,ko04147				Bacteria	1N7T2@1224,1RSBI@1236,3XNCF@561,COG0693@1,COG0693@2	NA|NA|NA	S	Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Is able to repair glycated serum albumin, collagen, glyceraldehyde-3-phosphate dehydrogenase, and fructose biphosphate aldolase. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of Schiff bases and advanced glycation endproducts (AGE) that cause irreversible damage. Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair. However, is less efficient than Hsp31 and YhbO, suggesting that YajL might be preferentially dedicated to protein repair. Displays a covalent chaperone activity with sulfenylated thiol proteins by forming mixed disulfides with members of the thiol proteome, and preferentially with sulfenylated cellular proteins, upon oxidative stress
C1_02818	469008.B21_00375	1.6e-274	951.4	Escherichia	thiI	GO:0000049,GO:0002937,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0017144,GO:0018130,GO:0019438,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042364,GO:0042723,GO:0042724,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122		R07461		ko00000,ko00001,ko01000,ko03016			iECNA114_1301.ECNA114_0400,iECO26_1355.ECO26_0455,iECSF_1327.ECSF_0383,iSDY_1059.SDY_0307	Bacteria	1MWD3@1224,1RNZT@1236,3XP27@561,COG0301@1,COG0301@2,COG0607@1,COG0607@2	NA|NA|NA	F	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C1_02819	155864.EDL933_0491	5.3e-34	149.8	Escherichia	xseB	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494	3.1.11.6	ko:K03602	ko03430,map03430				ko00000,ko00001,ko01000,ko03400				Bacteria	1N72V@1224,1SC7N@1236,3XQ1J@561,COG1722@1,COG1722@2	NA|NA|NA	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
C1_02820	198214.SF0358	9.2e-164	582.8	Gammaproteobacteria	ispA	GO:0003674,GO:0003824,GO:0004161,GO:0004337,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016114,GO:0016740,GO:0016765,GO:0019637,GO:0033383,GO:0033384,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0045337,GO:0045338,GO:0071704,GO:0090407,GO:1901576	2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90	ko:K00795,ko:K02523,ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061,R09248	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006			iPC815.YPO3176,iSFV_1184.SFV_0386	Bacteria	1MWNG@1224,1RMKY@1236,COG0142@1,COG0142@2	NA|NA|NA	H	Belongs to the FPP GGPP synthase family
C1_02821	316407.85674560	0.0	1243.0	Escherichia	dxs	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006725,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008614,GO:0008615,GO:0008654,GO:0008661,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009240,GO:0009987,GO:0016740,GO:0016744,GO:0017144,GO:0018130,GO:0019288,GO:0019438,GO:0019637,GO:0019682,GO:0019752,GO:0019842,GO:0030145,GO:0030975,GO:0030976,GO:0032787,GO:0034641,GO:0036094,GO:0040007,GO:0042180,GO:0042181,GO:0042364,GO:0042723,GO:0042724,GO:0042816,GO:0042819,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:1901135,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663,GO:1901681	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000			iEcSMS35_1347.EcSMS35_0456,iJN746.PP_0527	Bacteria	1MUSJ@1224,1RNQD@1236,3XMYA@561,COG1154@1,COG1154@2	NA|NA|NA	F	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C1_02822	469008.B21_00371	8.6e-184	649.4	Escherichia	yajO	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008152,GO:0009987,GO:0015672,GO:0016491,GO:0017144,GO:0030001,GO:0034220,GO:0034641,GO:0042723,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071704,GO:0071804,GO:0071805,GO:0072527,GO:0098655,GO:0098660,GO:0098662,GO:1901360,GO:1901564	1.1.1.91	ko:K05882					ko00000,ko01000				Bacteria	1MV2Y@1224,1RNXH@1236,3XNBU@561,COG0667@1,COG0667@2	NA|NA|NA	C	thiamine metabolic process
C1_02823	316407.85674558	1.3e-101	375.6	Escherichia	pgpA	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008962,GO:0009058,GO:0009987,GO:0010035,GO:0010038,GO:0016020,GO:0016021,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0030258,GO:0031224,GO:0031226,GO:0032026,GO:0042221,GO:0042577,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0046839,GO:0050896,GO:0071704,GO:0071944,GO:0090407,GO:1901576	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100		R02029	RC00017	ko00000,ko00001,ko01000			iECSP_1301.ECSP_0485,iECUMN_1333.ECUMN_0456,iECs_1301.ECs0471,iG2583_1286.G2583_0529,iPC815.YPO3179,iZ_1308.Z0520	Bacteria	1MZJA@1224,1S68A@1236,3XNNH@561,COG1267@1,COG1267@2	NA|NA|NA	I	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C1_02824	481805.EcolC_3216	1.2e-188	665.6	Escherichia	thiL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009030,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009229,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0035639,GO:0036094,GO:0042357,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000			iSFV_1184.SFV_0382,iYO844.BSU05900	Bacteria	1MU9X@1224,1RNHU@1236,3XMHS@561,COG0611@1,COG0611@2	NA|NA|NA	F	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C1_02825	1440052.EAKF1_ch1023c	4.7e-70	270.4	Escherichia	nusB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576		ko:K03625					ko00000,ko03009,ko03021				Bacteria	1RHFZ@1224,1S6AJ@1236,3XPIS@561,COG0781@1,COG0781@2	NA|NA|NA	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C1_02826	1006000.GKAS_02190	9.9e-77	292.7	Gammaproteobacteria	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000			iLJ478.TM1825,iSB619.SA_RS08940,iSFV_1184.SFV_0380	Bacteria	1RD9J@1224,1S3WD@1236,COG0054@1,COG0054@2	NA|NA|NA	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
C1_02827	316407.85674554	1e-209	735.7	Escherichia	ribD	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006725,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0008703,GO:0008835,GO:0009058,GO:0009110,GO:0009231,GO:0009451,GO:0009987,GO:0016070,GO:0016491,GO:0016614,GO:0016616,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0034641,GO:0036094,GO:0042364,GO:0042726,GO:0042727,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000			iB21_1397.B21_00366,iECBD_1354.ECBD_3247,iECB_1328.ECB_00362,iECD_1391.ECD_00362,iECED1_1282.ECED1_0437,iECNA114_1301.ECNA114_0391,iECSF_1327.ECSF_0374,iEcolC_1368.EcolC_3219,iJN746.PP_0514,iLF82_1304.LF82_1880,iNRG857_1313.NRG857_01945,iYL1228.KPN_00366,ic_1306.c0524	Bacteria	1MUWT@1224,1RN2M@1236,3XP5Z@561,COG0117@1,COG0117@2,COG1985@1,COG1985@2	NA|NA|NA	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1_02828	199310.c0523	6.5e-78	296.6	Escherichia	nrdR	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K07738					ko00000,ko03000				Bacteria	1RE7V@1224,1S3P9@1236,3XM7Q@561,COG1327@1,COG1327@2	NA|NA|NA	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C1_02829	199310.c0522	5.2e-90	337.0	Escherichia	yajI			ko:K06078					ko00000,ko01011				Bacteria	1R569@1224,1RQCG@1236,3XN74@561,COG4238@1,COG4238@2	NA|NA|NA	M	Protein of unknown function (DUF3251)
C1_02830	155864.EDL933_0479	2.6e-179	634.4	Escherichia	tsx	GO:0003674,GO:0005215,GO:0005337,GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0009279,GO:0015267,GO:0015288,GO:0015471,GO:0015858,GO:0015931,GO:0015932,GO:0016020,GO:0016021,GO:0016032,GO:0019058,GO:0019867,GO:0022803,GO:0022829,GO:0022857,GO:0030260,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0032991,GO:0044403,GO:0044409,GO:0044419,GO:0044425,GO:0044462,GO:0044464,GO:0046718,GO:0046930,GO:0051179,GO:0051234,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098796,GO:1901264,GO:1901505,GO:1901642		ko:K05517					ko00000,ko02000	1.B.10		iAF1260.b0411,iAPECO1_1312.APECO1_1599,iB21_1397.B21_00363,iBWG_1329.BWG_0293,iE2348C_1286.E2348C_0346,iEC042_1314.EC042_0446,iEC55989_1330.EC55989_0420,iECABU_c1320.ECABU_c04890,iECBD_1354.ECBD_3250,iECDH10B_1368.ECDH10B_0367,iECDH1ME8569_1439.ECDH1ME8569_0396,iECD_1391.ECD_00359,iECED1_1282.ECED1_0434,iECH74115_1262.ECH74115_0493,iECIAI1_1343.ECIAI1_0411,iECIAI39_1322.ECIAI39_0268,iECNA114_1301.ECNA114_0388,iECO103_1326.ECO103_0385,iECO111_1330.ECO111_0441,iECO26_1355.ECO26_0443,iECOK1_1307.ECOK1_0391,iECP_1309.ECP_0470,iECS88_1305.ECS88_0406,iECSE_1348.ECSE_0433,iECSP_1301.ECSP_0478,iECUMN_1333.ECUMN_0449,iECW_1372.ECW_m0480,iECs_1301.ECs0464,iEKO11_1354.EKO11_3438,iETEC_1333.ETEC_0464,iEcDH1_1363.EcDH1_3198,iEcE24377_1341.EcE24377A_0442,iEcHS_1320.EcHS_A0482,iEcSMS35_1347.EcSMS35_0445,iEcolC_1368.EcolC_3222,iG2583_1286.G2583_0522,iJO1366.b0411,iLF82_1304.LF82_2328,iNRG857_1313.NRG857_01930,iSDY_1059.SDY_0323,iSFV_1184.SFV_0376,iSF_1195.SF0348,iSFxv_1172.SFxv_0388,iS_1188.S0356,iUMN146_1321.UM146_15305,iUMNK88_1353.UMNK88_461,iWFL_1372.ECW_m0480,iY75_1357.Y75_RS02125	Bacteria	1MZ2A@1224,1RMH2@1236,3XMNH@561,COG3248@1,COG3248@2	NA|NA|NA	M	Nucleoside-specific channel-forming protein Tsx
C1_02831	155864.EDL933_0478	4.2e-64	250.4	Escherichia	yajD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100		R06613	RC00022,RC00332	ko00000,ko00001,ko01000				Bacteria	1RGZQ@1224,1S5V4@1236,3XPM7@561,COG1403@1,COG1403@2	NA|NA|NA	V	endonuclease activity
C1_02832	155864.EDL933_0474	2.6e-172	611.3	Escherichia	secF	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944		ko:K03072,ko:K03074,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7			Bacteria	1MU74@1224,1RNTY@1236,3XPBS@561,COG0341@1,COG0341@2	NA|NA|NA	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1_02833	155864.EDL933_0473	0.0	1123.6	Escherichia	secD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944		ko:K03072	ko03060,ko03070,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7			Bacteria	1MV5U@1224,1RMIQ@1236,3XMPQ@561,COG0342@1,COG0342@2	NA|NA|NA	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1_02834	155864.EDL933_0472	3.9e-51	207.2	Escherichia	yajC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031522,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2			Bacteria	1MZT2@1224,1S9NV@1236,3XPRI@561,COG1862@1,COG1862@2	NA|NA|NA	U	The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes
C1_02835	155864.EDL933_0471	1.5e-224	785.0	Escherichia	tgt	GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0008479,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.29	ko:K00773			R03789,R10209	RC00063	ko00000,ko01000,ko03016			iECW_1372.ECW_m0475,iWFL_1372.ECW_m0475	Bacteria	1MUCA@1224,1RMY3@1236,3XM9H@561,COG0343@1,COG0343@2	NA|NA|NA	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
C1_02836	1440052.EAKF1_ch1034c	2.9e-201	707.6	Escherichia	queA	GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009314,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0050896,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.29,2.4.99.17	ko:K00773,ko:K07568			R03789,R10209	RC00063	ko00000,ko01000,ko03016				Bacteria	1MUH3@1224,1RMKW@1236,3XNYX@561,COG0809@1,COG0809@2	NA|NA|NA	F	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C1_02837	316407.85674544	5.8e-111	406.8	Escherichia	acpH	GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008081,GO:0008150,GO:0008152,GO:0008610,GO:0008770,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0016788,GO:0019752,GO:0032787,GO:0042578,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:0140096,GO:1901576	3.1.4.14	ko:K08682	ko00770,map00770		R01623		ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_1606,iE2348C_1286.E2348C_0339,iECNA114_1301.ECNA114_0381,iECOK1_1307.ECOK1_0384,iECS88_1305.ECS88_0399,iECSF_1327.ECSF_0364,iPC815.YPO3193,iUMN146_1321.UM146_15340,iUTI89_1310.UTI89_C0426	Bacteria	1MZ59@1224,1S9IZ@1236,3XNP7@561,COG3124@1,COG3124@2	NA|NA|NA	I	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
C1_02838	155864.EDL933_0466	0.0	1266.1	Escherichia	malZ	GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0004558,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009311,GO:0009313,GO:0009987,GO:0015926,GO:0016052,GO:0016787,GO:0016798,GO:0030978,GO:0030980,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044464,GO:0051691,GO:0051692,GO:0071704,GO:0090599,GO:1901575	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100		R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000		GH31	iECH74115_1262.ECH74115_0480,iEcSMS35_1347.EcSMS35_0434,iSFV_1184.SFV_0368,iYL1228.KPN_00344	Bacteria	1MVKX@1224,1RQHM@1236,3XMY7@561,COG0366@1,COG0366@2	NA|NA|NA	G	May play a role in regulating the intracellular level of maltotriose. Cleaves glucose from the reducing end of maltotriose and longer maltodextrins with a chain length of up to 7 glucose units
C1_02839	199310.c0512	1.4e-256	891.7	Escherichia	proY	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03293,ko:K11736					ko00000,ko02000	2.A.3.1,2.A.3.1.6			Bacteria	1MUPS@1224,1RNHF@1236,3XM77@561,COG1113@1,COG1113@2	NA|NA|NA	E	Permease that is involved in the transport across the cytoplasmic membrane of proline
C1_02840	155864.EDL933_0464	1.8e-237	828.2	Escherichia	brnQ	GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015175,GO:0015179,GO:0015188,GO:0015190,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015820,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0022857,GO:0034220,GO:0042221,GO:0042493,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903785,GO:1903825,GO:1905039		ko:K03311					ko00000	2.A.26		iAF1260.b0401,iB21_1397.B21_00353,iBWG_1329.BWG_0283,iEC042_1314.EC042_0433,iECBD_1354.ECBD_3260,iECB_1328.ECB_00349,iECDH10B_1368.ECDH10B_0357,iECDH1ME8569_1439.ECDH1ME8569_0386,iECDH1ME8569_1439.EcDH1_3208,iECD_1391.ECD_00349,iECH74115_1262.ECH74115_0478,iECIAI1_1343.ECIAI1_0401,iECO103_1326.ECO103_0375,iECO111_1330.ECO111_0430,iECO26_1355.ECO26_0433,iECSE_1348.ECSE_0422,iECSP_1301.ECSP_0465,iECUMN_1333.ECUMN_0438,iECW_1372.ECW_m0470,iECs_1301.ECs0451,iEKO11_1354.EKO11_3448,iEcDH1_1363.EcDH1_3208,iEcE24377_1341.EcE24377A_0431,iEcHS_1320.EcHS_A0471,iEcolC_1368.EcolC_3232,iG2583_1286.G2583_0509,iJO1366.b0401,iJR904.b0401,iSBO_1134.SBO_0295,iSDY_1059.SDY_0336,iSSON_1240.SSON_0378,iSbBS512_1146.SbBS512_E0320,iUMNK88_1353.UMNK88_451,iWFL_1372.ECW_m0470,iY75_1357.Y75_RS02070,iZ_1308.Z0499	Bacteria	1MVIF@1224,1RR3P@1236,3XMX4@561,COG1114@1,COG1114@2	NA|NA|NA	E	Component of the transport system for branched-chain amino acids
C1_02841	198214.SF0337	1.4e-250	871.7	Gammaproteobacteria	phoR	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016021,GO:0016036,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031224,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0035556,GO:0036211,GO:0042578,GO:0042594,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071496,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.7.13.3	ko:K02484,ko:K07636	ko02020,map02020	M00434			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	1MWF3@1224,1RN0F@1236,COG5002@1,COG5002@2	NA|NA|NA	T	Histidine kinase
C1_02842	1440052.EAKF1_ch1041c	3.3e-129	467.6	Escherichia													Bacteria	1MY2Z@1224,1RN41@1236,3XMTI@561,COG0745@1,COG0745@2	NA|NA|NA	K	phosphate regulon transcriptional regulatory protein PhoB
C1_02843	155864.EDL933_0459	1.2e-227	795.4	Escherichia	sbcD	GO:0000014,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1990238		ko:K03547					ko00000,ko03400				Bacteria	1MVV6@1224,1RP83@1236,3XN92@561,COG0420@1,COG0420@2	NA|NA|NA	L	SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
C1_02844	198214.SF0334	0.0	1870.5	Gammaproteobacteria	sbcC	GO:0000014,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1990238		ko:K03546					ko00000,ko03400				Bacteria	1MVTQ@1224,1RQFM@1236,COG0419@1,COG0419@2	NA|NA|NA	L	SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
C1_02845	155864.EDL933_0457	2e-225	788.1	Gammaproteobacteria	araJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K08156,ko:K19577					ko00000,ko02000	2.A.1.2.14,2.A.1.2.65			Bacteria	1MU9G@1224,1RRZF@1236,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
C1_02846	316407.85674535	4.6e-171	607.1	Escherichia	mak	GO:0003674,GO:0003824,GO:0004396,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019318,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045127,GO:0046835,GO:0071704	2.7.1.4,2.7.1.59	ko:K00847,ko:K00884	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100		R00760,R00867,R01201,R03920	RC00002,RC00017	ko00000,ko00001,ko01000			iE2348C_1286.E2348C_1211,iECSE_1348.ECSE_0415,iEcHS_1320.EcHS_A0462,iPC815.YPO3211,iS_1188.S0338,iYL1228.KPN_00337	Bacteria	1MU94@1224,1RQ3P@1236,3XNWZ@561,COG1940@1,COG1940@2	NA|NA|NA	GK	Catalyzes the phosphorylation of fructose to fructose-6- P. Has also low level glucokinase activity in vitro. Is not able to phosphorylate D-ribose, D-mannitol, D-sorbitol, inositol, and L-threonine
C1_02847	199310.c0502	5.4e-178	630.2	Escherichia	rdgC	GO:0000018,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009295,GO:0019219,GO:0019222,GO:0031323,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363		ko:K03554					ko00000,ko03400				Bacteria	1MXPR@1224,1RMNN@1236,3XN1U@561,COG2974@1,COG2974@2	NA|NA|NA	J	May be involved in recombination
C1_02848	155864.EDL933_0451	6e-45	186.4	Escherichia	ppnP	GO:0003674,GO:0003824,GO:0004731,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016154,GO:0016740,GO:0016757,GO:0016763,GO:0044424,GO:0044444,GO:0044464	2.4.2.1,2.4.2.2	ko:K09913	ko00230,ko00240,map00230,map00240		R01561,R01570,R01863,R01876,R02147,R02296,R02297	RC00063,RC00122	ko00000,ko00001,ko01000				Bacteria	1MZ8N@1224,1S9G3@1236,3XPUX@561,COG3123@1,COG3123@2	NA|NA|NA	S	Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions
C1_02849	198214.SF0326	5.9e-115	420.2	Gammaproteobacteria	aroM			ko:K14591					ko00000				Bacteria	1R3SB@1224,1RQJ0@1236,COG4126@1,COG4126@2	NA|NA|NA	E	AroM protein
C1_02850	155864.EDL933_0449	4.1e-29	133.3	Escherichia	yaiA												Bacteria	1NA4W@1224,1SE9W@1236,2E4SC@1,32ZKT@2,3XQ2V@561	NA|NA|NA	S	YaiA protein
C1_02851	199310.c0495	2.7e-91	341.3	Escherichia	aroK	GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615	2.7.1.71,4.2.3.4	ko:K00891,ko:K13829,ko:K15546	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000,ko03000			iAPECO1_1312.APECO1_1620,iECOK1_1307.ECOK1_0367,iECS88_1305.ECS88_0383,iUMN146_1321.UM146_15425,iUTI89_1310.UTI89_C0407,iYL1228.KPN_00332	Bacteria	1RDCT@1224,1S7WF@1236,3XPSB@561,COG0703@1,COG0703@2	NA|NA|NA	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C1_02852	155864.EDL933_0447	1e-78	299.3	Escherichia	yaiI			ko:K09768					ko00000				Bacteria	1RCZA@1224,1S3QM@1236,3XN72@561,COG1671@1,COG1671@2	NA|NA|NA	S	Belongs to the UPF0178 family
C1_02853	198214.SF0322	1e-142	512.7	Gammaproteobacteria	proC	GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0017144,GO:0018130,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0055114,GO:0055129,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_0899,iIT341.HP1158,iSBO_1134.SBO_0282,ic_1306.c0493	Bacteria	1R5J1@1224,1RNQK@1236,COG0345@1,COG0345@2	NA|NA|NA	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C1_02854	199310.c0492	1.2e-210	738.8	Escherichia	adrA	GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0052621	2.7.7.65	ko:K18968	ko02026,map02026				ko00000,ko00001,ko01000,ko02000	9.B.34.1.2		iECSF_1327.ECSF_0346,ic_1306.c0492	Bacteria	1MZV7@1224,1RPR0@1236,3XN7R@561,COG2199@1,COG3706@2	NA|NA|NA	T	diguanylate cyclase. The last member of a cascade of expressed proteins, its expression requires YdaM. AdrA production induces biosynthesis of cellulose in some E.coli isolates, but not in K12 strains. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria
C1_02855	155864.EDL933_0444	1.4e-26	125.6	Escherichia	psiF												Bacteria	1N7N3@1224,1S6R3@1236,2E4IS@1,32ZDU@2,3XPNN@561	NA|NA|NA	S	psiF repeat
C1_02856	316407.85674524	3.5e-266	923.7	Escherichia	phoA	GO:0000287,GO:0003674,GO:0003824,GO:0004035,GO:0004721,GO:0005488,GO:0005575,GO:0005623,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016311,GO:0016491,GO:0016695,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0030288,GO:0030313,GO:0030613,GO:0031975,GO:0033748,GO:0036211,GO:0042578,GO:0042597,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0140096,GO:1901564	3.1.3.1,3.1.3.39	ko:K01077,ko:K04342	ko00521,ko00730,ko00790,ko01100,ko01130,ko02020,map00521,map00730,map00790,map01100,map01130,map02020	M00126	R02135,R02228,R04620	RC00017,RC00078	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147			iECO111_1330.ECO111_0413,iECO26_1355.ECO26_0416	Bacteria	1MXI2@1224,1RNG8@1236,3XP3C@561,COG1785@1,COG1785@2	NA|NA|NA	P	Belongs to the alkaline phosphatase family
C1_02857	155864.EDL933_0442	1.3e-38	165.2	Escherichia	iraP	GO:0000988,GO:0000989,GO:0003674,GO:0006355,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009889,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010605,GO:0010628,GO:0016036,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042176,GO:0042177,GO:0042594,GO:0043856,GO:0045893,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051248,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141											Bacteria	1N3ZW@1224,1SB6X@1236,2CMK9@1,32SF1@2,3XPWF@561	NA|NA|NA	J	Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS especially during phosphate starvation, but also in stationary phase and during nitrogen starvation. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway
C1_02858	155864.EDL933_0439	1.4e-203	715.3	Escherichia	ddl	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008716,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016020,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502		R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011			iAF1260.b0381,iB21_1397.B21_00332,iBWG_1329.BWG_0265,iE2348C_1286.E2348C_0317,iEC042_1314.EC042_0413,iEC55989_1330.EC55989_0386,iECBD_1354.ECBD_3283,iECB_1328.ECB_00328,iECDH10B_1368.ECDH10B_0338,iECDH1ME8569_1439.ECDH1ME8569_0367,iECD_1391.ECD_00328,iECH74115_1262.ECH74115_0453,iECIAI1_1343.ECIAI1_0377,iECIAI39_1322.ECIAI39_0301,iECO103_1326.ECO103_0356,iECO111_1330.ECO111_0411,iECO26_1355.ECO26_0095,iECO26_1355.ECO26_0414,iECSE_1348.ECSE_0401,iECSP_1301.ECSP_0441,iECs_1301.ECs0431,iETEC_1333.ETEC_0434,iEcDH1_1363.EcDH1_3227,iEcE24377_1341.EcE24377A_0406,iEcHS_1320.EcHS_A0447,iEcSMS35_1347.EcSMS35_0410,iEcolC_1368.EcolC_3251,iJO1366.b0381,iJR904.b0381,iSF_1195.SF0232,iSFxv_1172.SFxv_0245,iS_1188.S0254,iUMNK88_1353.UMNK88_429,iY75_1357.Y75_RS01965,iZ_1308.Z0477	Bacteria	1MUTB@1224,1RMTM@1236,3XP25@561,COG1181@1,COG1181@2	NA|NA|NA	F	Cell wall formation
C1_02859	155864.EDL933_0438	4.6e-34	149.8	Escherichia	yaiZ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1N38Y@1224,1SA26@1236,2CZ6J@1,32T5P@2,3XQ1G@561	NA|NA|NA	S	Protein of unknown function (DUF2754)
C1_02860	155864.EDL933_0437	7.2e-52	209.5	Escherichia	yaiY	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1MZ02@1224,1S9IH@1236,2CHSJ@1,32S6F@2,3XPWK@561	NA|NA|NA	S	Protein of unknown function (DUF2755)
C1_02861	155864.EDL933_0436	7.2e-203	713.0	Escherichia	yaiW	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009279,GO:0010033,GO:0010243,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031240,GO:0031975,GO:0042221,GO:0044424,GO:0044425,GO:0044444,GO:0044462,GO:0044464,GO:0050896,GO:0071944,GO:0098552,GO:1901652,GO:1901698,GO:1901700											Bacteria	1MVDT@1224,1RQ61@1236,28HWK@1,2Z82H@2,3XNC1@561	NA|NA|NA	S	response to peptide
C1_02862	469008.B21_00328	6.1e-227	793.1	Escherichia	sbmA	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0008150,GO:0015238,GO:0015291,GO:0015638,GO:0015833,GO:0015893,GO:0016020,GO:0016021,GO:0019534,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0042221,GO:0042493,GO:0042884,GO:0042885,GO:0042886,GO:0042887,GO:0042891,GO:0042895,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:1901998,GO:1904680		ko:K17938					ko00000,ko02000	9.A.18.1			Bacteria	1QU39@1224,1T1PR@1236,3XMQV@561,COG1133@1,COG1133@2	NA|NA|NA	U	Uptake of antimicrobial peptides. Required for the transport of microcin B17 (MccB17), microcin 25 (Mcc25) and proline-rich antimicrobial peptides into the cell
C1_02864	155864.EDL933_0433	4.4e-219	766.9	Escherichia	ampH	GO:0000270,GO:0003674,GO:0003824,GO:0004175,GO:0004180,GO:0005488,GO:0006022,GO:0006026,GO:0006027,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008360,GO:0008658,GO:0009056,GO:0009057,GO:0009253,GO:0016787,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031406,GO:0033218,GO:0033293,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044238,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0070011,GO:0071704,GO:0097159,GO:0140096,GO:1901135,GO:1901136,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901681	3.4.16.4	ko:K18988					ko00000,ko01000,ko01002,ko01011				Bacteria	1MVPR@1224,1RPF1@1236,3XNM5@561,COG1680@1,COG1680@2	NA|NA|NA	M	Hydrolyzes the cross-linked dimers tetrapentapeptide (D45) and tetratetrapeptide (D44). Removes the terminal D-alanine from muropeptides and disaccharide pentapeptide M5 with a C- terminal D-Ala-D-Ala dipeptide. Associated with recycling and remodeling of peptidoglycan (PG)
C1_02865	481805.EcolC_3257	3.5e-114	417.5	Escherichia	iprA	GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141		ko:K21828					ko00000,ko03000				Bacteria	1PAMQ@1224,1RSN8@1236,3XPT3@561,COG0664@1,COG0664@2	NA|NA|NA	K	Involved in oxidative stress resistance
C1_02866	469008.B21_00325	0.0	1551.6	Escherichia													Bacteria	1R5PB@1224,1RNAE@1236,3XQ9D@561,COG3468@1,COG3468@2	NA|NA|NA	MU	Autotransporter beta-domain
C1_02867	1440052.EAKF1_ch3017c	4.5e-43	180.3	Escherichia		GO:0005575,GO:0005623,GO:0008150,GO:0009279,GO:0009405,GO:0016020,GO:0019867,GO:0030260,GO:0030312,GO:0030313,GO:0031975,GO:0044403,GO:0044409,GO:0044419,GO:0044462,GO:0044464,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0071944		ko:K07483					ko00000				Bacteria	1RHBZ@1224,1S69Y@1236,3XR2P@561,COG2963@1,COG2963@2	NA|NA|NA	L	transposase activity
C1_02868	316407.1736794	7.5e-171	606.3	Gammaproteobacteria		GO:0008150,GO:0009987,GO:0032196		ko:K07497					ko00000				Bacteria	1MVXQ@1224,1RR4F@1236,COG2801@1,COG2801@2	NA|NA|NA	L	COG2801 Transposase and inactivated derivatives
C1_02869	155864.EDL933_0430	2.4e-178	631.3	Escherichia	hemB	GO:0000287,GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147			iECABU_c1320.ECABU_c04500,iEcSMS35_1347.EcSMS35_0398,iJN746.PP_2913,ic_1306.c0477	Bacteria	1MWMW@1224,1RP6Q@1236,3XNM2@561,COG0113@1,COG0113@2	NA|NA|NA	H	Belongs to the ALAD family
C1_02870	155864.EDL933_0429	1.3e-162	578.9	Escherichia	tauD	GO:0000907,GO:0000908,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006790,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016491,GO:0016705,GO:0016706,GO:0044237,GO:0044248,GO:0044273,GO:0044424,GO:0044464,GO:0051213,GO:0055114	1.14.11.17	ko:K03119	ko00430,ko00920,map00430,map00920		R05320	RC01331	ko00000,ko00001,ko01000			iB21_1397.B21_00322,iECBD_1354.ECBD_3293,iECB_1328.ECB_00318,iECD_1391.ECD_00318,iECH74115_1262.ECH74115_0443,iECSP_1301.ECSP_0431,iECs_1301.ECs0422,iETEC_1333.ETEC_0422,iEcolC_1368.EcolC_3260,iG2583_1286.G2583_0480,iJN746.PP_0230,iZ_1308.Z0467	Bacteria	1MV5K@1224,1RQRU@1236,3XMGN@561,COG2175@1,COG2175@2	NA|NA|NA	Q	Catalyzes the conversion of taurine and alpha ketoglutarate to sulfite, aminoacetaldehyde and succinate. Required for the utilization of taurine (2-aminoethanesulfonic acid) as an alternative sulfur source. Pentane-sulfonic acid, 3- (N-morpholino)propanesulfonic acid and 1,3-dioxo-2- isoindolineethanesulfonic acid are also substrates for this enzyme
C1_02871	198214.SF0251	1.2e-141	509.2	Gammaproteobacteria	tauC	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010438,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042594,GO:0042908,GO:0042910,GO:0042918,GO:0042959,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071496,GO:0071944		ko:K15552	ko00920,ko02010,map00920,map02010	M00435			ko00000,ko00001,ko00002,ko02000	3.A.1.17.1,3.A.1.17.4		iAPECO1_1312.APECO1_1637,iECOK1_1307.ECOK1_0349,iECS88_1305.ECS88_0364,iUMN146_1321.UM146_15525,iUTI89_1310.UTI89_C0386	Bacteria	1MWDJ@1224,1RQ0A@1236,COG0600@1,COG0600@2	NA|NA|NA	P	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1_02872	155864.EDL933_0427	2.3e-139	501.5	Escherichia	tauB	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0006950,GO:0007154,GO:0008144,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010438,GO:0017076,GO:0030554,GO:0031667,GO:0031668,GO:0031669,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0035639,GO:0036094,GO:0042594,GO:0043167,GO:0043168,GO:0050896,GO:0051716,GO:0071496,GO:0097159,GO:0097367,GO:1901265,GO:1901363	3.6.3.36	ko:K02049,ko:K10831	ko00920,ko02010,map00920,map02010	M00188,M00435			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.1,3.A.1.17.4		iE2348C_1286.E2348C_0306,iEcHS_1320.EcHS_A0430	Bacteria	1QTUA@1224,1RPAF@1236,3XMKD@561,COG4525@1,COG4525@2	NA|NA|NA	P	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C1_02873	469008.B21_00319	4.2e-175	620.5	Escherichia	tauA	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009970,GO:0009987,GO:0009991,GO:0015711,GO:0015734,GO:0015849,GO:0030288,GO:0030313,GO:0031667,GO:0031668,GO:0031669,GO:0031975,GO:0033554,GO:0042594,GO:0042597,GO:0042908,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0071496,GO:0071702,GO:0071705,GO:0072348		ko:K15551	ko00920,ko02010,map00920,map02010	M00435			ko00000,ko00001,ko00002,ko02000	3.A.1.17.1,3.A.1.17.4		iECOK1_1307.ECOK1_0347,iECS88_1305.ECS88_0362,iUMN146_1321.UM146_15535	Bacteria	1MVH2@1224,1RRRT@1236,3XM4M@561,COG4521@1,COG4521@2	NA|NA|NA	P	Sulfate starvation-induced protein 1
C1_02874	1440052.EAKF1_ch0283	1.5e-59	235.3	Escherichia	insC			ko:K07483					ko00000				Bacteria	1N0V0@1224,1S7WV@1236,3XRHH@561,COG2963@1,COG2963@2	NA|NA|NA	L	transposase activity
C1_02875	199310.c3611	1.9e-172	611.7	Escherichia		GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576		ko:K07483,ko:K07497					ko00000				Bacteria	1MY62@1224,1RQSR@1236,3XQHU@561,COG2801@1,COG2801@2	NA|NA|NA	L	DNA integration
C1_02876	481805.EcolC_3264	3.8e-122	444.1	Escherichia	yaiS												Bacteria	1MUTM@1224,1S7I4@1236,3XQ7I@561,COG2120@1,COG2120@2	NA|NA|NA	S	hydrolase activity
C1_02877	481805.EcolC_3265	1.3e-229	802.0	Escherichia	yaiP	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716											Bacteria	1R4DW@1224,1S1XD@1236,3XQC3@561,COG1215@1,COG1215@2	NA|NA|NA	M	transferase activity, transferring glycosyl groups
C1_02878	469008.B21_00316	1.9e-149	535.0	Escherichia	yaiO	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944											Bacteria	1N090@1224,1S8RC@1236,2CK01@1,32SB7@2,3XQEF@561	NA|NA|NA		
C1_02879	1440052.EAKF1_ch1073	1.8e-41	174.9	Escherichia	frmR	GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K21600					ko00000,ko03000				Bacteria	1N6ZN@1224,1S6I2@1236,3XQ3V@561,COG1937@1,COG1937@2	NA|NA|NA	K	Repressor of the frmRAB operon
C1_02880	155864.EDL933_0418	1.2e-213	748.8	Escherichia	adhC	GO:0003674,GO:0003824,GO:0004022,GO:0004024,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009636,GO:0009987,GO:0010033,GO:0016491,GO:0016614,GO:0016616,GO:0016999,GO:0017001,GO:0017144,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0046292,GO:0046294,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0051903,GO:0055114,GO:0070887,GO:0071704,GO:0097237,GO:0098754,GO:0110095,GO:0110096,GO:1901575,GO:1901700,GO:1901701,GO:1990748	1.1.1.1,1.1.1.284	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204		R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000			iEC042_1314.EC042_0393,iEC55989_1330.EC55989_0365,iECH74115_1262.ECH74115_0431,iECIAI1_1343.ECIAI1_0357,iECIAI39_1322.ECIAI39_0322,iECO103_1326.ECO103_0338,iECO111_1330.ECO111_0392,iECO26_1355.ECO26_0392,iECSE_1348.ECSE_0381,iECSP_1301.ECSP_0420,iECUMN_1333.ECUMN_0399,iECW_1372.ECW_m0434,iECs_1301.ECs0411,iEKO11_1354.EKO11_3486,iETEC_1333.ETEC_0412,iEcE24377_1341.EcE24377A_0381,iEcHS_1320.EcHS_A0421,iEcolC_1368.EcolC_3269,iG2583_1286.G2583_0469,iSSON_1240.SSON_0335,iSbBS512_1146.SbBS512_E0271,iUMNK88_1353.UMNK88_407,iWFL_1372.ECW_m0434,iZ_1308.Z0456	Bacteria	1MUK4@1224,1RNQ4@1236,3XM3K@561,COG1062@1,COG1062@2	NA|NA|NA	C	Has high formaldehyde dehydrogenase activity in the presence of glutathione and catalyzes the oxidation of normal alcohols in a reaction that is not GSH-dependent
C1_02881	469008.B21_00313	8.2e-159	566.2	Escherichia	fghA	GO:0003674,GO:0003824,GO:0006081,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0016999,GO:0017144,GO:0018738,GO:0044237,GO:0044281,GO:0046292,GO:0071704	3.1.2.12	ko:K01070,ko:K09795	ko00680,ko01120,ko01200,map00680,map01120,map01200		R00527	RC00167,RC00320	ko00000,ko00001,ko01000		CE1	iAF1260.b0355,iBWG_1329.BWG_0244,iE2348C_1286.E2348C_2300,iECDH10B_1368.ECDH10B_0310,iECDH1ME8569_1439.ECDH1ME8569_0342,iEcDH1_1363.EcDH1_3251,iG2583_1286.G2583_0468,iJO1366.b0355,iY75_1357.Y75_RS01830	Bacteria	1MUID@1224,1RMR3@1236,3XP8I@561,COG0627@1,COG0627@2	NA|NA|NA	S	Serine hydrolase involved in the detoxification of formaldehyde
C1_02882	316407.85674496	1.6e-70	272.3	Escherichia	yaiL	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K09912					ko00000			iECW_1372.ECW_m0432,iWFL_1372.ECW_m0432	Bacteria	1N15V@1224,1S5V0@1236,3XMK2@561,COG3122@1,COG3122@2	NA|NA|NA	S	Uncharacterized protein conserved in bacteria (DUF2058)
C1_02883	155864.EDL933_0415	2.7e-211	741.1	Escherichia	mhpT	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K05819,ko:K08195					ko00000,ko02000	2.A.1.15		iECO26_1355.ECO26_0389	Bacteria	1MVQQ@1224,1RXX6@1236,3XQD8@561,COG0477@1,COG2814@2	NA|NA|NA	P	Uptake of 3-(3-hydroxyphenyl)propionate (3HPP) across the cytoplasmic membrane. Transport is driven by the proton motive force. Does not transport benzoate, 3-hydroxybenzoate or gentisate
C1_02884	316407.85674494	4.2e-189	667.2	Escherichia	mhpE	GO:0003674,GO:0003824,GO:0008701,GO:0016829,GO:0016830,GO:0016833	4.1.3.39	ko:K01666	ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220	M00545,M00569	R00750	RC00307,RC00371	br01602,ko00000,ko00001,ko00002,ko01000			iECIAI39_1322.ECIAI39_0326,iEcSMS35_1347.EcSMS35_0383,iYL1228.KPN_02117	Bacteria	1MVQG@1224,1RPPW@1236,3XQEH@561,COG0119@1,COG0119@2	NA|NA|NA	E	Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of
C1_02885	316407.85674493	2.8e-171	607.8	Escherichia	mhpF	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0008774,GO:0016491,GO:0016620,GO:0016903,GO:0055114	1.2.1.10	ko:K04073	ko00360,ko00362,ko00620,ko00621,ko00622,ko00650,ko01100,ko01120,ko01220,map00360,map00362,map00620,map00621,map00622,map00650,map01100,map01120,map01220	M00545,M00569	R00228,R01172	RC00004,RC00184,RC01195	br01602,ko00000,ko00001,ko00002,ko01000			iECO26_1355.ECO26_0387	Bacteria	1MV23@1224,1RNDJ@1236,3XQHY@561,COG4569@1,COG4569@2	NA|NA|NA	Q	Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of
C1_02886	469008.B21_00308	5.7e-149	533.5	Escherichia	mhpD	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0008150,GO:0008152,GO:0008684,GO:0009056,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0019439,GO:0030145,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044248,GO:0044424,GO:0044464,GO:0046872,GO:0046914	4.2.1.80	ko:K02509,ko:K02554	ko00350,ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00350,map00360,map00362,map00621,map00622,map01100,map01120,map01220	M00545,M00569	R02601,R04132,R04781,R06897	RC00750,RC01213,RC01615,RC02595	br01602,ko00000,ko00001,ko00002,ko01000			iECIAI1_1343.ECIAI1_4571,iECO111_1330.ECO111_0386,iECO26_1355.ECO26_0386,iECW_1372.ECW_m0428,iEKO11_1354.EKO11_3492,iEcE24377_1341.EcE24377A_0374,iEcHS_1320.EcHS_A0414,iWFL_1372.ECW_m0428	Bacteria	1MVVV@1224,1RMZ4@1236,3XQGF@561,COG3971@1,COG3971@2	NA|NA|NA	Q	Catalyzes the conversion of 2-hydroxypentadienoic acid (enolic form of 2-oxopent-4-enoate) to 4-hydroxy-2-ketopentanoic acid
C1_02887	469008.B21_00307	1.3e-167	595.5	Escherichia	mhpC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006082,GO:0006725,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016787,GO:0016822,GO:0016823,GO:0018771,GO:0019439,GO:0019622,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046164,GO:0046395,GO:0046435,GO:0052823,GO:0071704,GO:0072329,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616	3.7.1.14,3.7.1.17,3.7.1.8	ko:K05714,ko:K10222,ko:K16050	ko00360,ko00621,ko00984,ko01100,ko01120,ko01220,map00360,map00621,map00984,map01100,map01120,map01220	M00543,M00545	R02603,R02606,R05359,R05360,R05361,R06789,R09883	RC00475,RC00476,RC00752,RC00753,RC00757,RC01337,RC02018,RC02740	br01602,ko00000,ko00001,ko00002,ko01000			iECDH10B_1368.ECDH10B_1361	Bacteria	1MVTG@1224,1T1TK@1236,3XQ5Y@561,COG0596@1,COG0596@2	NA|NA|NA	S	Catalyzes the cleavage of the C5-C6 bond of 2-hydroxy-6- oxononadienedioate and 2-hydroxy-6-oxononatrienedioate, a dienol ring fission product of the bacterial meta-cleavage pathway for degradation of phenylpropionic acid
C1_02888	155864.EDL933_0410	1.3e-179	635.6	Escherichia	mhpB	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006066,GO:0006082,GO:0006725,GO:0008150,GO:0008152,GO:0008198,GO:0009056,GO:0009698,GO:0009987,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019622,GO:0019748,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046271,GO:0046395,GO:0046435,GO:0046872,GO:0046914,GO:0047070,GO:0051213,GO:0055114,GO:0071704,GO:0072329,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616	1.13.11.16	ko:K05713	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R04376,R06788	RC01140,RC01364	br01602,ko00000,ko00001,ko00002,ko01000			iECIAI1_1343.ECIAI1_0349,iECO111_1330.ECO111_0384,iECO26_1355.ECO26_0384,iECSE_1348.ECSE_0373,iECW_1372.ECW_m0426,iEKO11_1354.EKO11_3494,iEcE24377_1341.EcE24377A_0372,iEcHS_1320.EcHS_A0412,iWFL_1372.ECW_m0426	Bacteria	1MW77@1224,1RR43@1236,3XQVF@561,COG3384@1,COG3384@2	NA|NA|NA	S	Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively
C1_02889	481805.EcolC_3278	0.0	1130.2	Escherichia	mhpA	GO:0006066,GO:0006082,GO:0006725,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0019439,GO:0019622,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046395,GO:0046435,GO:0071704,GO:0072329,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616	1.14.13.127	ko:K05712	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06786,R06787	RC00236	ko00000,ko00001,ko00002,ko01000			iECO103_1326.ECO103_0329	Bacteria	1MX9R@1224,1SYDP@1236,3XQES@561,COG0654@1,COG0654@2	NA|NA|NA	CH	Catalyzes the insertion of one atom of molecular oxygen into position 2 of the phenyl ring of 3-(3- hydroxyphenyl)propionate (3-HPP) and hydroxycinnamic acid (3HCI)
C1_02890	316407.85674488	2.8e-171	607.8	Escherichia	mhpR	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K02624,ko:K05818					ko00000,ko03000				Bacteria	1QRZN@1224,1RYF9@1236,3XQG0@561,COG1414@1,COG1414@2	NA|NA|NA	K	Activator of the mhpABCDFE operon coding for components of the 3-hydroxyphenylpropionate degradation pathway
C1_02891	1410620.SHLA_131c000030	1.6e-194	685.3	Rhizobiaceae	lacI	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042802,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K02529					ko00000,ko03000				Bacteria	1R47N@1224,2TV5N@28211,4BAFF@82115,COG1609@1,COG1609@2	NA|NA|NA	K	lacI family
C1_02892	316407.85674486	0.0	2138.6	Escherichia	lacZ	GO:0000287,GO:0003674,GO:0003824,GO:0004553,GO:0004565,GO:0005488,GO:0005515,GO:0005575,GO:0005975,GO:0005984,GO:0005988,GO:0005990,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009341,GO:0009987,GO:0015925,GO:0016052,GO:0016787,GO:0016798,GO:0031420,GO:0032991,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0046352,GO:0046872,GO:0071704,GO:1901575,GO:1902494	3.2.1.23	ko:K01190,ko:K12111	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100		R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000			iAF1260.b0344,iB21_1397.B21_00302,iECBD_1354.ECBD_3313,iECB_1328.ECB_00298,iECDH1ME8569_1439.ECDH1ME8569_0331,iECD_1391.ECD_00298,iECNA114_1301.ECNA114_0327,iEcDH1_1363.EcDH1_3262,iJO1366.b0344,iJR904.b0344,iY75_1357.Y75_RS01775	Bacteria	1MVBN@1224,1RMER@1236,3XNFH@561,COG3250@1,COG3250@2	NA|NA|NA	G	Belongs to the glycosyl hydrolase 2 family
C1_02893	199310.c0458	2.1e-227	794.7	Escherichia	lacY	GO:0003674,GO:0005215,GO:0005351,GO:0005402,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0008643,GO:0015075,GO:0015077,GO:0015078,GO:0015144,GO:0015154,GO:0015155,GO:0015157,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015528,GO:0015672,GO:0015766,GO:0015767,GO:0015772,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0030246,GO:0030395,GO:0031224,GO:0031226,GO:0034219,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0048030,GO:0051179,GO:0051234,GO:0055085,GO:0070492,GO:0071702,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600		ko:K02532					ko00000,ko02000	2.A.1.5		iAF1260.b0343,iAPECO1_1312.APECO1_1650,iB21_1397.B21_00301,iBWG_1329.BWG_3743,iE2348C_1286.E2348C_0298,iECABU_c1320.ECABU_c04330,iECBD_1354.ECBD_3314,iECB_1328.ECB_00297,iECDH10B_1368.ECDH10B_1356,iECDH1ME8569_1439.ECDH1ME8569_0330,iECD_1391.ECD_00297,iECED1_1282.ECED1_0371,iECO103_1326.ECO103_0325,iECO111_1330.ECO111_0379,iECO26_1355.ECO26_0379,iECOK1_1307.ECOK1_0335,iECP_1309.ECP_0416,iECS88_1305.ECS88_0350,iECSE_1348.ECSE_0368,iECUMN_1333.ECUMN_0386,iECW_1372.ECW_m0421,iEKO11_1354.EKO11_3499,iEcDH1_1363.EcDH1_3263,iEcE24377_1341.EcE24377A_0367,iEcSMS35_1347.EcSMS35_0374,iEcolC_1368.EcolC_3282,iJO1366.b0343,iJR904.b0343,iLF82_1304.LF82_1167,iNRG857_1313.NRG857_01660,iUMN146_1321.UM146_15590,iUMNK88_1353.UMNK88_393,iUTI89_1310.UTI89_C0370,iWFL_1372.ECW_m0421,iY75_1357.Y75_RS01770	Bacteria	1MYS9@1224,1RMRW@1236,3XN78@561,COG2223@1,COG2223@2	NA|NA|NA	P	Responsible for transport of beta-galactosides into the cell, with the concomitant import of a proton (symport system). Can transport lactose, melibiose, lactulose or the analog methyl- 1-thio-beta,D-galactopyranoside (TMG), but not sucrose or fructose. The substrate specificity is directed toward the galactopyranosyl moiety of the substrate
C1_02894	481805.EcolC_3284	1.7e-210	738.4	Gammaproteobacteria	cynX	GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009439,GO:0009440,GO:0009987,GO:0016020,GO:0034641,GO:0044237,GO:0044248,GO:0044270,GO:0044281,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901565,GO:1901575		ko:K03449					ko00000,ko02000	2.A.1.17		iEcSMS35_1347.EcSMS35_0372	Bacteria	1MXGT@1224,1RRH1@1236,COG2807@1,COG2807@2	NA|NA|NA	P	transporter
C1_02895	316407.85674482	6.2e-79	300.1	Escherichia	cynS	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0008824,GO:0009056,GO:0009439,GO:0009440,GO:0009987,GO:0016829,GO:0016840,GO:0034641,GO:0044237,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0071704,GO:1901564,GO:1901565,GO:1901575	4.2.1.104	ko:K01725	ko00910,map00910		R03546,R10079	RC00952	ko00000,ko00001,ko01000				Bacteria	1R9X0@1224,1S40B@1236,3XQZ4@561,COG1513@1,COG1513@2	NA|NA|NA	P	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
C1_02896	155864.EDL933_0399	1.9e-110	405.2	Escherichia	cynT	GO:0003674,GO:0003824,GO:0004089,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009439,GO:0009440,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0034641,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0071704,GO:1901564,GO:1901565,GO:1901575	4.2.1.1	ko:K01673	ko00910,map00910		R00132,R10092	RC02807	ko00000,ko00001,ko01000				Bacteria	1MV1U@1224,1SYDI@1236,3XQ72@561,COG0288@1,COG0288@2	NA|NA|NA	P	Reversible hydration of carbon dioxide. Carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (CynS) diffuses out of the cell faster than it would be hydrated to bicarbonate, so the apparent function of this enzyme is to catalyze the hydration of carbon dioxide and thus prevent depletion of cellular bicarbonate
C1_02897	155864.EDL933_0398	3.1e-159	567.8	Escherichia	cynR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464		ko:K11921					ko00000,ko03000				Bacteria	1NUAB@1224,1RNYQ@1236,3XQF2@561,COG0583@1,COG0583@2	NA|NA|NA	K	Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region
C1_02898	316407.85674479	1.7e-248	864.8	Escherichia	codA	GO:0003674,GO:0003824,GO:0004131,GO:0005488,GO:0005506,GO:0005515,GO:0006139,GO:0006206,GO:0006208,GO:0006209,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0019439,GO:0019858,GO:0034641,GO:0035888,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0046113,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	3.5.4.1	ko:K01485	ko00240,ko00330,ko01100,map00240,map00330,map01100		R00974,R01411,R02922	RC00074,RC00514,RC00809	ko00000,ko00001,ko01000			iECIAI39_1322.ECIAI39_0343,iEcSMS35_1347.EcSMS35_0368	Bacteria	1MX34@1224,1RMPF@1236,3XNWP@561,COG0402@1,COG0402@2	NA|NA|NA	F	Catalyzes the hydrolytic deamination of cytosine to uracil. Is involved in the pyrimidine salvage pathway, which allows the cell to utilize cytosine for pyrimidine nucleotide synthesis. Is also able to catalyze deamination of isoguanine, a mutagenic oxidation product of adenine in DNA, and of isocytosine. To a lesser extent, also catalyzes the conversion of 5- fluorocytosine (5FC) to 5-fluorouracil (5FU)
C1_02899	199310.c0455	3.1e-226	790.8	Escherichia	codB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K10974					ko00000,ko02000	2.A.39.1		iECW_1372.ECW_m0414,iEKO11_1354.EKO11_3506,iEcE24377_1341.EcE24377A_0360,iWFL_1372.ECW_m0414	Bacteria	1NS07@1224,1RNHG@1236,3XQVP@561,COG1457@1,COG1457@2	NA|NA|NA	F	Required for cytosine transport into the cell
C1_02900	155864.EDL933_0393	0.0	1274.2	Escherichia	prpE	GO:0003674,GO:0003824,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0050218	6.2.1.1,6.2.1.17	ko:K01895,ko:K01908	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004				Bacteria	1MUF5@1224,1RR14@1236,3XNFR@561,COG0365@1,COG0365@2	NA|NA|NA	I	Catalyzes the synthesis of propionyl-CoA from propionate and CoA. Also converts acetate to acetyl-CoA but with a lower specific activity (By similarity)
C1_02901	316407.85674476	6.9e-278	962.6	Escherichia	prpD	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017001,GO:0017144,GO:0019541,GO:0019543,GO:0019626,GO:0019629,GO:0019679,GO:0019752,GO:0032787,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0046459,GO:0047547,GO:0048037,GO:0051536,GO:0051537,GO:0051540,GO:0071704,GO:0072329,GO:1901575	4.2.1.79	ko:K01720	ko00640,map00640		R04424	RC01152	ko00000,ko00001,ko01000			iEcolC_1368.EcolC_3291	Bacteria	1MUIG@1224,1RPQN@1236,3XNFN@561,COG2079@1,COG2079@2	NA|NA|NA	S	Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the stereospecific dehydration of (2S,3S)-2- methylcitrate (2-MC) to yield the cis isomer of 2-methyl- aconitate
C1_02902	362663.ECP_0408	4.2e-225	786.9	Escherichia	prpC	GO:0003674,GO:0003824,GO:0004108,GO:0006082,GO:0006091,GO:0006113,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016740,GO:0016746,GO:0016829,GO:0016830,GO:0016833,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0036440,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0046459,GO:0046912,GO:0050440,GO:0055114,GO:0071704	2.3.3.1,2.3.3.5	ko:K01647,ko:K01659	ko00020,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351,R00931	RC00004,RC00067,RC00406,RC02827	br01601,ko00000,ko00001,ko00002,ko01000			iECED1_1282.ECED1_0365,iECIAI1_1343.ECIAI1_0334,iECIAI39_1322.ECIAI39_0347,iECP_1309.ECP_0408,iECSF_1327.ECSF_0308,iEcE24377_1341.EcE24377A_0357,iJN746.PP_2335,iLF82_1304.LF82_1740,iNRG857_1313.NRG857_01630	Bacteria	1MUKX@1224,1RNT1@1236,3XME6@561,COG0372@1,COG0372@2	NA|NA|NA	C	Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the Claisen condensation of propionyl-CoA and oxaloacetate (OAA) to yield (2S,3S)-2-methylcitrate (2-MC) and CoA. Also catalyzes the condensation of oxaloacetate with acetyl- CoA to yield citrate but with a lower specificity
C1_02903	316407.85674474	1.5e-158	565.5	Escherichia	prpB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016829,GO:0016830,GO:0016833,GO:0016999,GO:0017001,GO:0017144,GO:0019541,GO:0019543,GO:0019626,GO:0019629,GO:0019752,GO:0032787,GO:0042737,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0046421,GO:0046459,GO:0046872,GO:0071704,GO:0072329,GO:1901575	4.1.3.30	ko:K03417	ko00640,map00640		R00409	RC00286,RC00287	ko00000,ko00001,ko01000			iECNA114_1301.ECNA114_0319,iECP_1309.ECP_0407	Bacteria	1N4VT@1224,1RMR5@1236,3XNCE@561,COG2513@1,COG2513@2	NA|NA|NA	G	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C1_02904	316407.85674473	3e-295	1020.4	Escherichia	prpR	GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009314,GO:0009628,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141		ko:K02688					ko00000,ko03000				Bacteria	1NU8B@1224,1RMHY@1236,3XMTX@561,COG3829@1,COG3829@2	NA|NA|NA	K	propionate catabolism operon regulatory protein
C1_02905	316407.85674472	9.6e-40	169.1	Escherichia	yahO	GO:0008150,GO:0009314,GO:0009628,GO:0050896											Bacteria	1N47F@1224,1SAJT@1236,2DN1T@1,32V0M@2,3XPVH@561	NA|NA|NA	S	response to radiation
C1_02906	316407.85674471	5.7e-112	410.2	Escherichia	yahN	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015318,GO:0015711,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:1903825,GO:1905039		ko:K03329					ko00000,ko02000	2.A.76.1.3			Bacteria	1P5IT@1224,1RYYK@1236,3XMDJ@561,COG1280@1,COG1280@2	NA|NA|NA	E	amino acid transmembrane transporter activity
C1_02909	155864.EDL933_0384	1.4e-203	715.3	Escherichia	yahK	GO:0003674,GO:0003824,GO:0004033,GO:0008106,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0055114	1.1.1.1	ko:K12957,ko:K13953,ko:K13979	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220		R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000				Bacteria	1MUTT@1224,1RN4D@1236,3XP1W@561,COG1064@1,COG1064@2	NA|NA|NA	S	Catalyzes the reduction of a wide range of aldehydes into their corresponding alcohols. Has a strong preference for NADPH over NADH as the electron donor. Cannot use a ketone as substrate. Is a major source of NADPH-dependent aldehyde reductase activity in E.coli. The in vivo functions of YahK has yet to be determined
C1_02910	155864.EDL933_0383	2.7e-166	591.3	Escherichia				ko:K02057		M00221			ko00000,ko00002,ko02000	3.A.1.2			Bacteria	1MV1D@1224,1RRD6@1236,3XNMM@561,COG1172@1,COG1172@2	NA|NA|NA	U	Branched-chain amino acid transport system / permease component
C1_02911	155864.EDL933_0382	1.2e-172	612.5	Escherichia				ko:K02057		M00221			ko00000,ko00002,ko02000	3.A.1.2			Bacteria	1Q5HX@1224,1RRTE@1236,3XPHM@561,COG1172@1,COG1172@2	NA|NA|NA	U	Branched-chain amino acid transport system / permease component
C1_02912	630626.EBL_c34080	6.9e-225	786.6	Gammaproteobacteria			3.6.3.17	ko:K02056		M00221			ko00000,ko00002,ko01000,ko02000	3.A.1.2			Bacteria	1MU22@1224,1RSEP@1236,COG1129@1,COG1129@2	NA|NA|NA	G	ABC transporter
C1_02913	155864.EDL933_0379	9.1e-181	639.4	Escherichia	lsrB_2			ko:K02058,ko:K10559	ko02010,map02010	M00220,M00221			ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.9			Bacteria	1MUAT@1224,1RP2R@1236,3XPB1@561,COG1879@1,COG1879@2	NA|NA|NA	G	Periplasmic binding protein domain
C1_02914	155864.EDL933_0377	1.9e-71	275.0	Escherichia			3.4.13.21	ko:K05995,ko:K06888					ko00000,ko01000,ko01002				Bacteria	1N2T4@1224,1S2GH@1236,3XPZ2@561,COG4405@1,COG4405@2	NA|NA|NA	S	ASCH
C1_02915	316407.85674467	1.2e-260	905.2	Escherichia	yahJ	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016787,GO:0016810,GO:0016814,GO:0044424,GO:0044444,GO:0044464											Bacteria	1MX34@1224,1RNSH@1236,3XMWY@561,COG0402@1,COG0402@2	NA|NA|NA	F	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
C1_02916	481805.EcolC_3300	8.5e-176	622.9	Escherichia	yahI	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200		R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000			iECIAI39_1322.ECIAI39_3289,iECSF_1327.ECSF_0300,iEcE24377_1341.EcE24377A_0559,iEcHS_1320.EcHS_A0383	Bacteria	1MWXC@1224,1RP78@1236,3XNE0@561,COG0549@1,COG0549@2	NA|NA|NA	E	Belongs to the carbamate kinase family
C1_02917	469008.B21_00280	9.4e-272	942.2	Escherichia	yahG												Bacteria	1QWBP@1224,1T2T0@1236,3XN3J@561,COG1304@1,COG1304@2	NA|NA|NA	C	Protein of unknown function (DUF1116)
C1_02918	316407.85674463	6.2e-285	986.1	Escherichia	sucD	GO:0001539,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006928,GO:0008150,GO:0008152,GO:0009361,GO:0009987,GO:0016310,GO:0019538,GO:0032991,GO:0036211,GO:0040011,GO:0042709,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0046777,GO:0048870,GO:0051179,GO:0051674,GO:0071704,GO:0071973,GO:0097588,GO:1901564,GO:1902494	6.2.1.5	ko:K01902,ko:K02381	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000			iE2348C_1286.E2348C_0608	Bacteria	1MWWN@1224,1RME7@1236,3XNEQ@561,COG0074@1,COG0074@2	NA|NA|NA	C	cofactor binding
C1_02919	469008.B21_00278	1.8e-164	585.1	Escherichia	yahE												Bacteria	1R7G4@1224,1S0VF@1236,2DBAX@1,2Z84Q@2,3XMBA@561	NA|NA|NA	S	Protein of unknown function (DUF2877)
C1_02920	316407.85674461	3.9e-110	404.1	Escherichia	yahD	GO:0008150,GO:0009314,GO:0009628,GO:0050896		ko:K06867					ko00000				Bacteria	1N952@1224,1RPZA@1236,3XMWF@561,COG0666@1,COG0666@2	NA|NA|NA	S	response to radiation
C1_02921	469008.B21_00276	5.9e-88	330.1	Escherichia	yahC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1RA3H@1224,1S33K@1236,2DC16@1,2ZCC8@2,3XMM2@561	NA|NA|NA	S	Protein of unknown function (DUF1097)
C1_02922	199310.c0436	4.1e-175	620.5	Escherichia	yahB	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576		ko:K10972					ko00000,ko03000				Bacteria	1P293@1224,1RNA3@1236,3XN6I@561,COG0583@1,COG0583@2	NA|NA|NA	K	DNA-binding transcription factor activity
C1_02923	155864.EDL933_0365	8.7e-209	732.6	Escherichia	yahA	GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0006355,GO:0008081,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016787,GO:0016788,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042578,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071111,GO:0080090,GO:0097159,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141	3.1.4.52	ko:K13244,ko:K21090	ko02026,map02026		R08991	RC00296	ko00000,ko00001,ko01000				Bacteria	1QWBM@1224,1SNPT@1236,3XQF7@561,COG2200@1,COG2200@2,COG2771@1,COG2771@2	NA|NA|NA	K	Hydrolyzes c-di-GMP (cyclic bis(3'-5') dimeric GMP) to 5'-pGpG, known as PDE-A activity. PDE-B activity, that is hydrolysis of 5'-pGpG to GMP, proceeds only very slowly
C1_02924	155864.EDL933_0364	0.0	2393.2	Escherichia				ko:K07279,ko:K12678					ko00000,ko02000,ko02044	1.B.12,1.B.12.1.1,1.B.12.1.3			Bacteria	1R8WV@1224,1RPXJ@1236,3XQIF@561,COG2911@1,COG2911@2,COG3468@1,COG3468@2	NA|NA|NA	MU	Autotransporter beta-domain
C1_02925	155864.EDL933_0363	0.0	1332.0	Gammaproteobacteria	betT	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033554,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0071944		ko:K02168					ko00000,ko02000	2.A.15.1.3,2.A.15.1.4		iAF1260.b0314,iB21_1397.B21_00273,iEC042_1314.EC042_0347,iEC55989_1330.EC55989_0316,iECBD_1354.ECBD_3344,iECB_1328.ECB_00270,iECDH10B_1368.ECDH10B_0301,iECD_1391.ECD_00270,iECH74115_1262.ECH74115_0376,iECIAI1_1343.ECIAI1_0311,iECO103_1326.ECO103_0291,iECO111_1330.ECO111_0348,iECO26_1355.ECO26_0348,iECSE_1348.ECSE_0335,iECSP_1301.ECSP_0369,iECUMN_1333.ECUMN_0352,iECW_1372.ECW_m0388,iECs_1301.ECs0360,iEKO11_1354.EKO11_3531,iEcDH1_1363.EcDH1_3292,iEcE24377_1341.EcE24377A_0331,iEcHS_1320.EcHS_A0373,iEcolC_1368.EcolC_3309,iG2583_1286.G2583_0418,iJO1366.b0314,iJR904.b0314,iUMNK88_1353.UMNK88_361,iWFL_1372.ECW_m0388,iY75_1357.Y75_RS01625,iZ_1308.Z0401	Bacteria	1MV0K@1224,1RP3E@1236,COG1292@1,COG1292@2	NA|NA|NA	M	Belongs to the BCCT transporter (TC 2.A.15) family
C1_02926	199310.c0433	2.9e-102	377.9	Gammaproteobacteria	betI	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006950,GO:0006970,GO:0008150,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K02167					ko00000,ko03000				Bacteria	1MX72@1224,1RZBH@1236,COG1309@1,COG1309@2	NA|NA|NA	K	Repressor involved in choline regulation of the bet genes
C1_02927	316407.85674455	1e-276	958.7	Gammaproteobacteria	betB	GO:0001505,GO:0003674,GO:0003824,GO:0004029,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006575,GO:0006577,GO:0006578,GO:0006807,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0008802,GO:0009058,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016043,GO:0016491,GO:0016620,GO:0016903,GO:0019285,GO:0019695,GO:0022607,GO:0031455,GO:0031456,GO:0034641,GO:0042133,GO:0042398,GO:0042802,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0065007,GO:0065008,GO:0071704,GO:0071840,GO:0097164,GO:1901564,GO:1901566,GO:1901576	1.2.1.8	ko:K00130	ko00260,ko01100,map00260,map01100	M00555	R02565,R02566	RC00080	ko00000,ko00001,ko00002,ko01000			iEC042_1314.EC042_0345,iECOK1_1307.ECOK1_0306,iECS88_1305.ECS88_0320,iECSF_1327.ECSF_0290	Bacteria	1MU1V@1224,1RMBQ@1236,COG1012@1,COG1012@2	NA|NA|NA	C	belongs to the aldehyde dehydrogenase family
C1_02928	316407.85674454	0.0	1157.5	Gammaproteobacteria	betA	GO:0001505,GO:0003674,GO:0003824,GO:0005575,GO:0006091,GO:0006113,GO:0006575,GO:0006577,GO:0006578,GO:0006807,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0008812,GO:0009058,GO:0009628,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016614,GO:0019285,GO:0019695,GO:0031455,GO:0031456,GO:0034641,GO:0042133,GO:0042398,GO:0044237,GO:0044249,GO:0044271,GO:0050896,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_1679,iECDH10B_1368.ECDH10B_0298,iECDH1ME8569_1439.ECDH1ME8569_0299,iECH74115_1262.ECH74115_0373,iECOK1_1307.ECOK1_0305,iECS88_1305.ECS88_0319,iECSP_1301.ECSP_0366,iECs_1301.ECs0357,iEcDH1_1363.EcDH1_3295,iEcolC_1368.EcolC_3312,iG2583_1286.G2583_0415,iJN746.PP_5064,iJO1366.b0311,iUMN146_1321.UM146_15745,iY75_1357.Y75_RS01610,iZ_1308.Z0398	Bacteria	1MV19@1224,1RMD2@1236,COG2303@1,COG2303@2	NA|NA|NA	E	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C1_02929	362663.ECP_0378	1.1e-116	426.0	Gammaproteobacteria	ykgH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1NTTX@1224,1SMEI@1236,2CJY1@1,33T67@2	NA|NA|NA		
C1_02930	198214.SF0258	5.1e-122	443.7	Gammaproteobacteria	lutC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K00782					ko00000			iECO111_1330.ECO111_0342,iECO26_1355.ECO26_0342	Bacteria	1N67T@1224,1RNC6@1236,COG1556@1,COG1556@2	NA|NA|NA	S	LUD domain
C1_02931	199310.c0423	6.3e-276	956.1	Escherichia	lutB			ko:K18929					ko00000			iSF_1195.SF0259,iSFxv_1172.SFxv_0274,iS_1188.S0280	Bacteria	1MV6J@1224,1RQEA@1236,3XP0B@561,COG1139@1,COG1139@2	NA|NA|NA	C	lactate oxidation
C1_02932	198214.SF0260	6.7e-133	479.9	Gammaproteobacteria	lutA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K18928					ko00000			iEC042_1314.EC042_0340,iEcSMS35_1347.EcSMS35_0338	Bacteria	1MWTK@1224,1RMVZ@1236,COG0247@1,COG0247@2	NA|NA|NA	C	Fe-S oxidoreductase
C1_02933	316407.85674449	6.5e-159	566.6	Escherichia	ykgD	GO:0001130,GO:0001216,GO:0003674,GO:0003700,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090347,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141		ko:K18991,ko:K21746		M00647			ko00000,ko00002,ko03000				Bacteria	1PF5X@1224,1S0K6@1236,3XN8T@561,COG2207@1,COG2207@2	NA|NA|NA	K	Involved in reactive chlorine species (RCS) stress resistance. Upregulates, in response to hypochlorous acid (HOCl), the expression of three genes essential for survival of RCS stress (rclA, rclB and rclC) and its own expression
C1_02934	571.MC52_00430	1.4e-248	865.1	Gammaproteobacteria	merA	GO:0000302,GO:0000305,GO:0001101,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016491,GO:0016667,GO:0019725,GO:0042221,GO:0042592,GO:0044424,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1901530,GO:1901700,GO:1990748	1.16.1.1,1.8.1.7	ko:K00383,ko:K00520,ko:K21739	ko00480,ko04918,map00480,map04918		R00094,R00115	RC00011	ko00000,ko00001,ko01000				Bacteria	1MU2U@1224,1RQTU@1236,COG1249@1,COG1249@2	NA|NA|NA	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1_02935	481805.EcolC_3319	8.3e-105	386.3	Escherichia	ykgB	GO:0000302,GO:0001101,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006082,GO:0006089,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009438,GO:0009987,GO:0010035,GO:0010467,GO:0016020,GO:0016053,GO:0016070,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019172,GO:0019243,GO:0019249,GO:0019438,GO:0019752,GO:0032774,GO:0032787,GO:0034641,GO:0034645,GO:0034654,GO:0042180,GO:0042182,GO:0042221,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044464,GO:0046185,GO:0046394,GO:0046483,GO:0050896,GO:0051596,GO:0061727,GO:0071704,GO:0071944,GO:0072330,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901530,GO:1901575,GO:1901576,GO:1901615,GO:1901617,GO:1901700		ko:K21741					ko00000				Bacteria	1R6WS@1224,1S0X7@1236,3XMGM@561,COG3059@1,COG3059@2	NA|NA|NA	S	response to hypochlorite
C1_02936	155864.EDL933_0340	1.1e-163	582.4	Escherichia	ykgA	GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006089,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009438,GO:0009987,GO:0010467,GO:0016053,GO:0016070,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019172,GO:0019243,GO:0019249,GO:0019438,GO:0019752,GO:0032774,GO:0032787,GO:0034641,GO:0034645,GO:0034654,GO:0042180,GO:0042182,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046185,GO:0046394,GO:0046483,GO:0051596,GO:0061727,GO:0071704,GO:0072330,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901575,GO:1901576,GO:1901615,GO:1901617		ko:K05804,ko:K13653		M00647,M00767			ko00000,ko00002,ko03000,ko03036				Bacteria	1RIE3@1224,1S84A@1236,3XRJH@561,COG2207@1,COG2207@2,COG3708@1,COG3708@2	NA|NA|NA	K	Bacterial transcription activator, effector binding domain
C1_02937	155864.EDL933_0339	0.0	2613.6	Escherichia	eaeH	GO:0005575,GO:0005623,GO:0008150,GO:0009279,GO:0009405,GO:0016020,GO:0019867,GO:0030260,GO:0030312,GO:0030313,GO:0031975,GO:0044403,GO:0044409,GO:0044419,GO:0044462,GO:0044464,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0071944		ko:K13735	ko05100,map05100				ko00000,ko00001				Bacteria	1MX9S@1224,1RPK7@1236,3XN7T@561,COG1388@1,COG1388@2	NA|NA|NA	M	cell adhesion
C1_02939	199310.c0407	1.1e-43	182.2	Escherichia	rpmE2	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0033554,GO:0034224,GO:0034641,GO:0034645,GO:0042594,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0120127,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02909	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1MZ4D@1224,1S8V5@1236,3XPXP@561,COG0254@1,COG0254@2	NA|NA|NA	J	50S ribosomal protein L31 type B
C1_02940	155864.EDL933_0328	5.8e-17	92.4	Gammaproteobacteria	rpmJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02919	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1NGBJ@1224,1SCR7@1236,COG0257@1,COG0257@2	NA|NA|NA	J	Belongs to the bacterial ribosomal protein bL36 family
C1_02941	481805.EcolC_3325	1.4e-95	355.5	Gammaproteobacteria	matA			ko:K08087,ko:K21907,ko:K21963					ko00000,ko03000				Bacteria	1NRJZ@1224,1SJJF@1236,COG2771@1,COG2771@2	NA|NA|NA	K	Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition
C1_02942	481805.EcolC_3326	1.3e-97	362.5	Gammaproteobacteria	matB			ko:K21964					ko00000,ko02044				Bacteria	1QW80@1224,1RS9V@1236,28JUN@1,2Z9JQ@2	NA|NA|NA	S	Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition. Major subunit of the fimbria
C1_02943	316407.85674436	6e-120	436.8	Gammaproteobacteria	ecpB			ko:K21965					ko00000,ko02044				Bacteria	1PB5I@1224,1S197@1236,COG3121@1,COG3121@2	NA|NA|NA	M	Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition (By similarity)
C1_02944	316407.85674435	0.0	1642.1	Gammaproteobacteria	ecpC			ko:K21966					ko00000,ko02044				Bacteria	1R2PY@1224,1RMJX@1236,COG3188@1,COG3188@2	NA|NA|NA	NU	Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition (By similarity)
C1_02945	316407.85674434	0.0	1109.7	Gammaproteobacteria	yagW			ko:K21967					ko00000,ko02044				Bacteria	1R4XB@1224,1RNFY@1236,28J32@1,2Z8ZC@2	NA|NA|NA	S	Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition. Tip pilus adhesin, which is required for assembly of EcpA into fibers (By similarity)
C1_02946	469008.B21_00251	4.7e-131	473.8	Gammaproteobacteria	ecpE			ko:K21968					ko00000,ko02044				Bacteria	1R9G7@1224,1RSAU@1236,COG3121@1,COG3121@2	NA|NA|NA	NU	Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition (By similarity)
C1_02947	155864.EDL933_0318	8.9e-118	429.5	Escherichia	yagU	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009268,GO:0009628,GO:0010447,GO:0016020,GO:0044464,GO:0050896,GO:0071944		ko:K08996					ko00000				Bacteria	1MV9E@1224,1RYHM@1236,3XQGU@561,COG3477@1,COG3477@2	NA|NA|NA	S	response to acidic pH
C1_02948	481805.EcolC_3333	2.9e-125	454.5	Escherichia	yagT	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0042597,GO:0044464,GO:0048037,GO:0051536,GO:0051537,GO:0051540,GO:0055114	1.3.99.16	ko:K07302,ko:K12528,ko:K13480,ko:K13483	ko00230,ko00450,ko01100,ko01120,map00230,map00450,map01100,map01120	M00546	R01768,R02103,R07229	RC00143,RC02420	ko00000,ko00001,ko00002,ko01000			iECH74115_1262.ECH74115_4158,iECSP_1301.ECSP_3838,iECs_1301.ECs3741,iZ_1308.Z4207	Bacteria	1MY3F@1224,1SYEX@1236,3XNYV@561,COG2080@1,COG2080@2	NA|NA|NA	F	Iron-sulfur subunit of the xanthine dehydrogenase complex
C1_02949	316407.85674429	1.4e-173	615.5	Escherichia	yagS	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.17.1.4	ko:K11178	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000				Bacteria	1MVJS@1224,1RY6A@1236,3XP71@561,COG1319@1,COG1319@2	NA|NA|NA	F	xanthine dehydrogenase activity
C1_02950	316407.85674428	0.0	1450.3	Escherichia	yagR	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016903,GO:0030151,GO:0033554,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114	1.17.1.4	ko:K11177	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000				Bacteria	1MUEA@1224,1RN40@1236,3XMZP@561,COG1529@1,COG1529@2	NA|NA|NA	F	xanthine dehydrogenase activity
C1_02951	316407.85674427	7e-178	629.8	Escherichia	yagQ	GO:0003674,GO:0005488,GO:0043546,GO:0048037,GO:0050662,GO:0097159,GO:1901363		ko:K07402					ko00000				Bacteria	1MXKU@1224,1RQRT@1236,3XP8J@561,COG1975@1,COG1975@2	NA|NA|NA	O	molybdopterin cofactor binding
C1_02952	481805.EcolC_3337	8.9e-74	282.7	Gammaproteobacteria	yagP	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141											Bacteria	1MU2E@1224,1RYUY@1236,COG0583@1,COG0583@2	NA|NA|NA	K	transcriptional regulator
C1_02953	634499.EpC_35610	4.8e-13	82.0	Gammaproteobacteria				ko:K07454					ko00000				Bacteria	1RIM8@1224,1S7RX@1236,COG3440@1,COG3440@2	NA|NA|NA	V	HNH endonuclease
C1_02954	349965.yinte0001_5850	2e-76	292.0	Gammaproteobacteria				ko:K15773					ko00000,ko02048,ko03000				Bacteria	1REU5@1224,1SHHD@1236,COG1396@1,COG1396@2	NA|NA|NA	K	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C1_02956	1249634.D781_2565	5.6e-192	677.6	Gammaproteobacteria													Bacteria	1R6JR@1224,1RS6D@1236,2DBH4@1,2Z97J@2	NA|NA|NA		
C1_02957	1440052.EAKF1_ch3907c	2.6e-57	228.4	Escherichia													Bacteria	1R3XB@1224,1RSC2@1236,3XR1Z@561,COG1961@1,COG1961@2	NA|NA|NA	L	Resolvase, N terminal domain
C1_02959	1500894.JQNN01000001_gene256	4.4e-07	60.8	Betaproteobacteria													Bacteria	1PBQ5@1224,295WQ@1,2W6B1@28216,2ZT7M@2	NA|NA|NA		
C1_02960	216591.BCAL3079	2.6e-65	255.8	Burkholderiaceae													Bacteria	1KFAE@119060,1P939@1224,2DC50@1,2W3Y9@28216,2ZCXE@2	NA|NA|NA		
C1_02961	155864.EDL933_5620	6.7e-32	142.9	Gammaproteobacteria													Bacteria	1N2ZR@1224,1S9ST@1236,2DZND@1,32VEJ@2	NA|NA|NA		
C1_02962	561231.Pecwa_3428	5.7e-308	1062.8	Gammaproteobacteria													Bacteria	1REKP@1224,1T01S@1236,COG0582@1,COG0582@2	NA|NA|NA	L	Belongs to the 'phage' integrase family
C1_02963	561231.Pecwa_3428	4.3e-22	109.8	Gammaproteobacteria													Bacteria	1REKP@1224,1T01S@1236,COG0582@1,COG0582@2	NA|NA|NA	L	Belongs to the 'phage' integrase family
C1_02965	316407.85674395	1.5e-225	788.5	Escherichia	proA	GO:0003674,GO:0003824,GO:0004350,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0018130,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0055114,GO:0055129,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000			iB21_1397.B21_00243,iECBD_1354.ECBD_3376,iECB_1328.ECB_00240,iECD_1391.ECD_00240,iLJ478.TM0293,iYL1228.KPN_00280,iYO844.BSU13130	Bacteria	1MUGJ@1224,1RMAY@1236,3XN41@561,COG0014@1,COG0014@2	NA|NA|NA	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C1_02966	155864.EDL933_0275	1e-201	709.1	Escherichia	proB	GO:0000287,GO:0003674,GO:0003824,GO:0004349,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019202,GO:0019752,GO:0031406,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0055129,GO:0071704,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901973	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000				Bacteria	1MUBG@1224,1RM7X@1236,3XM4J@561,COG0263@1,COG0263@2	NA|NA|NA	F	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C1_02967	155864.EDL933_0274	3.5e-199	700.7	Escherichia	phoE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009279,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016021,GO:0019219,GO:0019222,GO:0019867,GO:0030312,GO:0030313,GO:0031224,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031975,GO:0032991,GO:0044424,GO:0044425,GO:0044444,GO:0044462,GO:0044464,GO:0045893,GO:0045935,GO:0046930,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0098796,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141		ko:K11929					ko00000,ko02000	1.B.1.1.2		iECO26_1355.ECO26_0297	Bacteria	1MVRY@1224,1RNBS@1236,3XPDV@561,COG3203@1,COG3203@2	NA|NA|NA	M	Belongs to the Gram-negative porin family
C1_02968	469008.B21_00238	5.1e-74	283.5	Escherichia	crl	GO:0003674,GO:0003700,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141		ko:K11926					ko00000,ko03000				Bacteria	1N4UT@1224,1S3WH@1236,292QM@1,2ZQ8E@2,3XPPE@561	NA|NA|NA	K	Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32
C1_02969	198214.SF0287	1.7e-248	864.8	Gammaproteobacteria	frsA	GO:0003674,GO:0003824,GO:0005575,GO:0006109,GO:0006629,GO:0008150,GO:0008152,GO:0009894,GO:0016020,GO:0016298,GO:0016787,GO:0016788,GO:0019222,GO:0043470,GO:0044238,GO:0050789,GO:0065007,GO:0071704,GO:0080090		ko:K11750					ko00000,ko01000				Bacteria	1N5CG@1224,1RR2Y@1236,COG1073@1,COG1073@2	NA|NA|NA	S	Belongs to the UPF0255 family
C1_02970	155864.EDL933_0271	8.1e-84	316.2	Escherichia	gpt	GO:0000310,GO:0003674,GO:0003824,GO:0004422,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006166,GO:0006177,GO:0006188,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032261,GO:0032263,GO:0032264,GO:0032265,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0043094,GO:0043101,GO:0043173,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046040,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097292,GO:0097293,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.22	ko:K00769,ko:K07101	ko00230,ko01100,ko01110,map00230,map01100,map01110		R01229,R02142	RC00063,RC00122	ko00000,ko00001,ko01000			iSbBS512_1146.SbBS512_E0235	Bacteria	1MWNE@1224,1RQ4C@1236,3XMFY@561,COG2236@1,COG2236@2	NA|NA|NA	F	Acts on guanine, xanthine and to a lesser extent hypoxanthine
C1_02971	155864.EDL933_0270	9.6e-280	968.8	Escherichia	pepD	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0009056,GO:0009987,GO:0016787,GO:0016805,GO:0019538,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0070573,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575		ko:K01270	ko00480,ko01100,map00480,map01100		R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002			iPC815.YPO3230,iSBO_1134.SBO_0243	Bacteria	1MUWK@1224,1RP5F@1236,3XN1M@561,COG2195@1,COG2195@2	NA|NA|NA	E	Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipeptide amides and formyl amino acids are hydrolyzed. Also shows cysteinylglycinase activity, which is sufficient for E.coli to utilize cysteinylglycine as a cysteine source
C1_02972	199310.c0382	2.3e-110	404.8	Escherichia	prfH			ko:K02839					ko00000,ko03012				Bacteria	1R9YA@1224,1RR3F@1236,3XQBB@561,COG1186@1,COG1186@2	NA|NA|NA	J	RF-1 domain
C1_02973	362663.ECP_0264	3.2e-214	750.7	Escherichia	rtcB		6.5.1.3	ko:K14415,ko:K18148	ko01501,map01501				ko00000,ko00001,ko01000,ko03016				Bacteria	1MUHA@1224,1RN50@1236,3XQXS@561,COG1690@1,COG1690@2	NA|NA|NA	S	tRNA-splicing ligase RtcB
C1_02974	198214.SF0282	2.5e-77	294.7	Proteobacteria	yafP		5.3.1.16	ko:K01814,ko:K03830,ko:K07146	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000				Bacteria	1QUD7@1224,COG0454@1,COG0454@2	NA|NA|NA	K	acetyltransferase
C1_02975	199310.c0379	1.6e-199	701.8	Escherichia	dinB	GO:0000731,GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019985,GO:0031668,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02346,ko:K03502					ko00000,ko01000,ko03400				Bacteria	1MUUH@1224,1RMFM@1236,3XNHP@561,COG0389@1,COG0389@2	NA|NA|NA	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C1_02976	155864.EDL933_0263	1.7e-108	398.7	Escherichia	motB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02557	ko02030,ko02040,map02030,map02040				ko00000,ko00001,ko02000,ko02035	1.A.30.1			Bacteria	1MW1Y@1224,1RPQ9@1236,3XN14@561,COG1360@1,COG1360@2	NA|NA|NA	N	OmpA family
C1_02977	155864.EDL933_0262	0.0	1088.2	Escherichia	flhA			ko:K02400	ko02040,map02040				ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3			Bacteria	1MUF3@1224,1RMSM@1236,3XM97@561,COG1298@1,COG1298@2	NA|NA|NA	NU	FHIPEP family
C1_02978	693444.D782_2723	8.2e-47	192.6	unclassified Enterobacteriaceae	hicA												Bacteria	1N7H4@1224,1S9Z1@1236,283M8@191675,2CT64@1,32SSN@2	NA|NA|NA	S	HicA toxin of bacterial toxin-antitoxin,
C1_02979	693444.D782_2724	6.4e-60	236.5	unclassified Enterobacteriaceae	hicB												Bacteria	1MZYR@1224,1SAHX@1236,283MX@191675,COG4226@1,COG4226@2	NA|NA|NA	S	HicB family
C1_02980	155864.EDL933_0258	1.2e-140	505.8	Escherichia	yafL		3.2.1.14,3.4.17.13	ko:K01183,ko:K13694,ko:K13695,ko:K19303,ko:K21471	ko00520,ko01100,map00520,map01100		R01206,R02334	RC00467	ko00000,ko00001,ko01000,ko01002,ko01011		GH18		Bacteria	1N0EE@1224,1RP3P@1236,3XP3U@561,COG0791@1,COG0791@2	NA|NA|NA	M	cysteine-type peptidase activity
C1_02981	469008.B21_00225	1e-38	165.6	Gammaproteobacteria	dinJ	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0015643,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0032991,GO:0032993,GO:0042710,GO:0043254,GO:0043565,GO:0044010,GO:0044087,GO:0044212,GO:0044764,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051704,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141		ko:K07473					ko00000,ko02048				Bacteria	1NA1R@1224,1SBX3@1236,COG3077@1,COG3077@2	NA|NA|NA	K	Antitoxin component of a type II toxin-antitoxin (TA) system. A labile antitoxin that counteracts the effect of cognate toxin YafQ. YafQ and DinJ together bind their own promoter, and repress its expression. There are 2 operators with imperfect inverted repeats (IR) in the dinJ promoter, YafQ-(DinJ)2-YafQ only binds to the first (most upstream) of them to repress transcription
C1_02982	481805.EcolC_3395	8.2e-47	192.6	Gammaproteobacteria	yafQ	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0005575,GO:0006139,GO:0006401,GO:0006402,GO:0006412,GO:0006415,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0019222,GO:0019439,GO:0019538,GO:0022411,GO:0032984,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034655,GO:0042221,GO:0042710,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043565,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044010,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044267,GO:0044270,GO:0044271,GO:0044764,GO:0044877,GO:0046483,GO:0046677,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0051704,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576		ko:K19157					ko00000,ko01000,ko02048				Bacteria	1N9NX@1224,1SCBQ@1236,COG3041@1,COG3041@2	NA|NA|NA	S	Toxic component of a type II toxin-antitoxin (TA) system. A sequence-specific mRNA endoribonuclease that inhibits translation elongation and induces bacterial stasis. Cleavage occurs between the second and third residue of the Lys codon followed by a G or A (5'AAA(G A)3'), is reading-frame dependent and occurs within the 5' end of most mRNAs. Ribosome-binding confers the sequence specificity and reading frame-dependence. When overexpressed in liquid media YafQ partially inhibits protein synthesis, with a reduction in growth rate and colony growth rate. This effect is counteracted by coexpression with cognate antitoxin DinJ. YafQ and DinJ together bind their own promoter, and repress its expression
C1_02983	155864.EDL933_0254	7.6e-140	503.1	Escherichia	yafK												Bacteria	1MXY6@1224,1RPXT@1236,3XP6E@561,COG3034@1,COG3034@2	NA|NA|NA	M	peptidoglycan biosynthetic process
C1_02984	316407.4902959	4.5e-151	540.4	Escherichia	yafJ												Bacteria	1MU1J@1224,1RNEK@1236,3XM9M@561,COG0121@1,COG0121@2	NA|NA|NA	S	glutamine metabolic process
C1_02985	1440052.EAKF1_ch1194c	8.4e-102	376.3	Escherichia	gmhA	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008968,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016853,GO:0016866,GO:0016868,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	5.3.1.28	ko:K03271,ko:K12961	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005,ko03036				Bacteria	1NVIE@1224,1RP6M@1236,3XND9@561,COG0279@1,COG0279@2	NA|NA|NA	G	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate
C1_02986	316407.85674387	0.0	1617.8	Escherichia	fadE	GO:0003674,GO:0003824,GO:0003995,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016491,GO:0016627,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575		ko:K06445	ko00071,ko01100,ko01212,map00071,map01100,map01212	M00087	R01175,R01279,R03777,R03857,R03990,R04751,R04754	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000			iSbBS512_1146.SbBS512_E0217	Bacteria	1MUDR@1224,1RPM5@1236,3XNAM@561,COG1960@1,COG1960@2	NA|NA|NA	I	Catalyzes the dehydrogenation of acyl-coenzymes A (acyl- CoAs) to 2-enoyl-CoAs, the first step of the beta-oxidation cycle of fatty acid degradation. Is required for
C1_02987	155864.EDL933_0250	7.2e-77	293.1	Escherichia	ivy	GO:0003674,GO:0004857,GO:0005575,GO:0005623,GO:0006457,GO:0008150,GO:0009987,GO:0030234,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043086,GO:0044092,GO:0044464,GO:0050790,GO:0060241,GO:0061077,GO:0065007,GO:0065009,GO:0098772											Bacteria	1QJ60@1224,1RPEI@1236,29IKC@1,305HJ@2,3XNE1@561	NA|NA|NA	O	Inhibitor of vertebrate lysozyme
C1_02988	316407.85674386	2.3e-147	528.1	Escherichia	yafV	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0044464,GO:0050152,GO:0071944,GO:0106008	3.5.1.3	ko:K11206,ko:K13566	ko00250,map00250		R00269,R00348	RC00010	ko00000,ko00001,ko01000				Bacteria	1MXBR@1224,1RQ4Z@1236,3XME3@561,COG0388@1,COG0388@2	NA|NA|NA	S	Hydrolyzes alpha-ketoglutaramate (a-KGM) to alpha- ketoglutarate (alpha-KG) and ammonia, has weak activity on L- glutamine, almost no activity on deaminated glutathione (dGSH) and none on glutathione (By similarity). May function as a metabolite repair enzyme (By similarity)
C1_02989	481805.EcolC_2203	1.9e-197	694.9	Escherichia													Bacteria	1MXB5@1224,1RSAV@1236,3XQUD@561,COG5433@1,COG5433@2	NA|NA|NA	L	transposase
C1_02990	316407.85674976	1.6e-137	495.4	Gammaproteobacteria	yncI												Bacteria	1MXB5@1224,1RSAV@1236,COG5433@1,COG5433@2	NA|NA|NA	L	Transposase
C1_02992	502347.ESCAB7627_0380	0.0	1898.2	Escherichia													Bacteria	1MVV1@1224,1SKYM@1236,3XPUS@561,COG3209@1,COG3209@2	NA|NA|NA	M	RHS Repeat
C1_02993	155864.EDL933_0239	0.0	1159.1	Escherichia	vgrG			ko:K11904	ko03070,map03070	M00334			ko00000,ko00001,ko00002,ko02044	3.A.23.1			Bacteria	1MU7Q@1224,1RMZS@1236,3XNWQ@561,COG3501@1,COG3501@2	NA|NA|NA	S	Phage late control gene D protein (GPD)
C1_02994	155864.EDL933_0237	5e-98	363.6	Escherichia	hcp			ko:K11903	ko02025,ko03070,map02025,map03070	M00334			ko00000,ko00001,ko00002,ko02044				Bacteria	1MXFB@1224,1RNKQ@1236,3XQDN@561,COG3157@1,COG3157@2	NA|NA|NA	S	Type VI secretion system effector, Hcp
C1_02995	155864.EDL933_0235	6.8e-84	316.6	Escherichia	impB			ko:K11901	ko02025,map02025	M00334			ko00000,ko00001,ko00002,ko02044	3.A.23.1			Bacteria	1RBNB@1224,1S2BT@1236,3XRH1@561,COG3516@1,COG3516@2	NA|NA|NA	S	Type VI secretion system, VipA, VC_A0107 or Hcp2
C1_02997	155864.EDL933_0233	7.8e-269	932.6	Escherichia	evpB			ko:K11900	ko02025,map02025	M00334			ko00000,ko00001,ko00002,ko02044	3.A.23.1			Bacteria	1MU5C@1224,1RNP7@1236,3XPS2@561,COG3517@1,COG3517@2	NA|NA|NA	S	Type VI secretion protein, EvpB/VC_A0108, tail sheath
C1_02998	155864.EDL933_0232	4.6e-70	270.4	Gammaproteobacteria				ko:K11905		M00334			ko00000,ko00002,ko02044				Bacteria	1RE8H@1224,1SA9K@1236,COG3518@1,COG3518@2	NA|NA|NA	S	protein conserved in bacteria
C1_02999	155864.EDL933_0231	0.0	1260.4	Escherichia	vasA			ko:K11896		M00334			ko00000,ko00002,ko02044	3.A.23.1			Bacteria	1MUY4@1224,1RPK4@1236,3XQWH@561,COG3519@1,COG3519@2	NA|NA|NA	S	Type VI secretion system, TssF
C1_03000	155864.EDL933_0230	3.3e-208	730.7	Gammaproteobacteria	impH			ko:K11895	ko02025,map02025	M00334			ko00000,ko00001,ko00002,ko02044	3.A.23.1			Bacteria	1MWVS@1224,1RQD5@1236,COG3520@1,COG3520@2	NA|NA|NA	S	type VI secretion protein
C1_03001	155864.EDL933_0229	2.9e-240	837.4	Gammaproteobacteria	impI			ko:K11894,ko:K11913	ko02025,ko03070,map02025,map03070				ko00000,ko00001,ko02044	3.A.23.1			Bacteria	1MUKE@1224,1RQGW@1236,COG3456@1,COG3456@2	NA|NA|NA	T	conserved protein, contains FHA domain
C1_03002	155864.EDL933_0228	6e-91	340.1	Gammaproteobacteria	vasD			ko:K11906	ko03070,map03070	M00334			ko00000,ko00001,ko00002,ko02044	3.A.23.1			Bacteria	1MX5E@1224,1S83T@1236,COG3521@1,COG3521@2	NA|NA|NA	S	protein conserved in bacteria
C1_03003	155864.EDL933_0227	5.4e-253	879.8	Escherichia	impJ			ko:K11893	ko02025,map02025	M00334			ko00000,ko00001,ko00002,ko02044	3.A.23.1			Bacteria	1MXKE@1224,1RNCB@1236,3XPQ4@561,COG3522@1,COG3522@2	NA|NA|NA	S	Bacterial Type VI secretion, VC_A0110, EvfL, ImpJ, VasE
C1_03004	155864.EDL933_0226	1.4e-141	508.8	Escherichia	vasF			ko:K11892	ko03070,map03070	M00334			ko00000,ko00001,ko00002,ko02044	3.A.23.1			Bacteria	1MU13@1224,1S2PW@1236,3XQXV@561,COG3455@1,COG3455@2	NA|NA|NA	N	Type VI secretion system protein DotU
C1_03005	155864.EDL933_0225	0.0	1713.0	Escherichia	clpV			ko:K03696,ko:K11907	ko01100,ko02025,ko03070,map01100,map02025,map03070	M00334			ko00000,ko00001,ko00002,ko02044,ko03110	3.A.23.1			Bacteria	1MVBH@1224,1RMZH@1236,3XPGF@561,COG0542@1,COG0542@2	NA|NA|NA	O	C-terminal, D2-small domain, of ClpB protein
C1_03006	155864.EDL933_0224	5.3e-133	480.3	Gammaproteobacteria	vasI			ko:K11909					ko00000,ko02044	3.A.23.1			Bacteria	1N3SX@1224,1SBDD@1236,2C9Y5@1,32RR9@2	NA|NA|NA	S	Type VI secretion-associated protein, VC_A0118 family
C1_03007	693444.D782_3645	1.8e-80	305.4	Gammaproteobacteria	vasJ			ko:K11910		M00334			ko00000,ko00002,ko02044	3.A.23.1			Bacteria	1MWDQ@1224,1RQXI@1236,COG3515@1,COG3515@2	NA|NA|NA	S	protein conserved in bacteria
C1_03008	155864.EDL933_0221	0.0	2234.5	Escherichia	icmF			ko:K11891,ko:K12210	ko02025,ko03070,map02025,map03070	M00334			ko00000,ko00001,ko00002,ko02044	3.A.23.1,3.A.7.9.1			Bacteria	1MV3D@1224,1RPQ2@1236,3XQSN@561,COG3523@1,COG3523@2	NA|NA|NA	S	ImcF-related N-terminal domain
C1_03009	155864.EDL933_0220	1.9e-245	854.7	Gammaproteobacteria				ko:K11911		M00334			ko00000,ko00002,ko02044	3.A.23.1			Bacteria	1Q02U@1224,1RQNJ@1236,COG3515@1,COG3515@2	NA|NA|NA	M	ImpA domain protein
C1_03010	1440052.EAKF1_ch1203	2.9e-79	301.2	Escherichia				ko:K06887					ko00000				Bacteria	1RB0U@1224,1S2CP@1236,3XR91@561,COG3157@1,COG3157@2	NA|NA|NA	S	Type VI secretion system effector, Hcp
C1_03011	1440052.EAKF1_ch1204	1e-157	562.8	Escherichia													Bacteria	1QUEZ@1224,1T1WG@1236,28JEE@1,2Z98M@2,3XR0I@561	NA|NA|NA		
C1_03012	511145.b4586	3.5e-69	267.7	Escherichia		GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0042221,GO:0046677,GO:0050896,GO:0051716											Bacteria	1QIHE@1224,1TGC1@1236,2AVGC@1,31M8I@2,3XQG3@561	NA|NA|NA		
C1_03013	316407.4902953	5.1e-142	510.4	Escherichia	yafT												Bacteria	1MWA4@1224,1S0IC@1236,28N94@1,2ZBD8@2,3XQDQ@561	NA|NA|NA		
C1_03015	481805.EcolC_3450	4.8e-134	483.8	Escherichia	dnaQ	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016787,GO:0016788,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0045004,GO:0045005,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0090304,GO:0090305,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7,3.1.26.4	ko:K02342,ko:K14159	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Bacteria	1MV8Z@1224,1RNHQ@1236,3XMNA@561,COG0847@1,COG0847@2	NA|NA|NA	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C1_03016	155864.EDL933_0214	6.6e-89	333.2	Escherichia	rnhA	GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005488,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1901576	3.1.26.4	ko:K03469	ko03030,map03030				ko00000,ko00001,ko01000,ko03032				Bacteria	1RCZ1@1224,1S3YC@1236,3XNJ9@561,COG0328@1,COG0328@2	NA|NA|NA	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C1_03017	469008.B21_00211	4.8e-139	500.4	Escherichia	yafS												Bacteria	1QTWC@1224,1RS4G@1236,3XMFC@561,COG0500@1,COG2226@2	NA|NA|NA	Q	methyltransferase activity
C1_03018	155864.EDL933_0212	1e-144	519.2	Escherichia	gloB	GO:0003674,GO:0003824,GO:0004416,GO:0005488,GO:0006081,GO:0006082,GO:0006089,GO:0006950,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009266,GO:0009408,GO:0009438,GO:0009628,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019243,GO:0019752,GO:0032787,GO:0042180,GO:0042182,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046185,GO:0046872,GO:0046914,GO:0050896,GO:0051596,GO:0061727,GO:0071704,GO:1901575,GO:1901615	3.1.2.6	ko:K01069	ko00620,map00620		R01736	RC00004,RC00137	ko00000,ko00001,ko01000			iECABU_c1320.ECABU_c02250	Bacteria	1MU8Q@1224,1S22I@1236,3XMRR@561,COG0491@1,COG0491@2	NA|NA|NA	S	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1_03019	199310.c0248	1.3e-229	802.0	Escherichia	mltD	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008932,GO:0008933,GO:0009893,GO:0016020,GO:0016740,GO:0016757,GO:0019222,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043085,GO:0044093,GO:0044464,GO:0048518,GO:0050789,GO:0050790,GO:0051341,GO:0051353,GO:0061783,GO:0065007,GO:0065009		ko:K08307,ko:K12204					ko00000,ko01000,ko01011,ko02044	3.A.7.10.1,3.A.7.9.1			Bacteria	1MWKE@1224,1RMFZ@1236,3XMF8@561,COG0741@1,COG0741@2,COG1388@1,COG1388@2	NA|NA|NA	M	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division (By similarity)
C1_03020	155864.EDL933_0210	5.9e-135	486.9	Escherichia	yafE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044464											Bacteria	1PN45@1224,1RP4K@1236,3XNY0@561,COG0500@1,COG2226@2	NA|NA|NA	Q	S-adenosylmethionine-dependent methyltransferase activity
C1_03021	155864.EDL933_0209	2.4e-144	518.1	Escherichia	yafD												Bacteria	1MVPP@1224,1RMBH@1236,3XNMK@561,COG3021@1,COG3021@2	NA|NA|NA	S	UPF0294 protein YafD
C1_03022	316407.4902945	7.9e-163	579.7	Escherichia	yafC	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576											Bacteria	1MU7H@1224,1RPF8@1236,3XM7Z@561,COG0583@1,COG0583@2	NA|NA|NA	K	Transcriptional regulator
C1_03023	481805.EcolC_3458	1.1e-144	519.2	Escherichia	dkgB	GO:0003674,GO:0003824,GO:0004033,GO:0006081,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0042180,GO:0042182,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046185,GO:0047681,GO:0051596,GO:0055114,GO:0071704,GO:1901575,GO:1990002	1.1.1.346	ko:K06222					ko00000,ko01000			iEcolC_1368.EcolC_3458	Bacteria	1MWFS@1224,1RMX6@1236,3XPB8@561,COG0656@1,COG0656@2	NA|NA|NA	S	Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG)
C1_03030	155864.EDL933_0206	8.6e-107	392.9	Escherichia	gmhB	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0033692,GO:0034200,GO:0034637,GO:0034645,GO:0042578,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046872,GO:0046914,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	3.1.3.15,3.1.3.82,3.1.3.83,4.2.1.19,6.3.2.10	ko:K01089,ko:K01929,ko:K03273	ko00300,ko00340,ko00540,ko00550,ko01100,ko01110,ko01230,ko01502,map00300,map00340,map00540,map00550,map01100,map01110,map01230,map01502	M00026,M00064	R03013,R03457,R04573,R04617,R05647,R09771	RC00017,RC00064,RC00141,RC00932	ko00000,ko00001,ko00002,ko01000,ko01005,ko01011			iB21_1397.B21_00198,iEC55989_1330.EC55989_0198,iECBD_1354.ECBD_3418,iECB_1328.ECB_00199,iECD_1391.ECD_00199,iECIAI1_1343.ECIAI1_0202,iECO103_1326.ECO103_0200,iECS88_1305.ECS88_2121,iECSE_1348.ECSE_0202,iETEC_1333.ETEC_0196,iEcHS_1320.EcHS_A0204,iEcolC_1368.EcolC_3459,iUMNK88_1353.UMNK88_2570	Bacteria	1RDGR@1224,1S3UD@1236,3XN2T@561,COG0241@1,COG0241@2	NA|NA|NA	F	by removing the phosphate group at the C-7 position
C1_03031	155864.EDL933_0205	1.5e-189	668.7	Escherichia	metN	GO:0000099,GO:0000101,GO:0000166,GO:0003333,GO:0003674,GO:0003824,GO:0005215,GO:0005342,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008144,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015179,GO:0015191,GO:0015238,GO:0015318,GO:0015399,GO:0015405,GO:0015711,GO:0015807,GO:0015821,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0031224,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034220,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042940,GO:0042943,GO:0043167,GO:0043168,GO:0043190,GO:0043492,GO:0043865,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0048473,GO:0048474,GO:0050896,GO:0051179,GO:0051234,GO:0055052,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0097159,GO:0097367,GO:0098533,GO:0098655,GO:0098656,GO:0098796,GO:0098797,GO:1901265,GO:1901363,GO:1901682,GO:1902475,GO:1902494,GO:1902495,GO:1903825,GO:1904949,GO:1905039,GO:1990351		ko:K02071	ko02010,map02010	M00238			ko00000,ko00001,ko00002,ko02000	3.A.1.24		iAF1260.b0199,iBWG_1329.BWG_0192,iECDH10B_1368.ECDH10B_0180,iECDH1ME8569_1439.ECDH1ME8569_0193,iECP_1309.ECP_0209,iEcDH1_1363.EcDH1_3403,iEcSMS35_1347.EcSMS35_0211,iJO1366.b0199,iJR904.b0199,iUMNK88_1353.UMNK88_205,iY75_1357.Y75_RS01010	Bacteria	1QTTK@1224,1RMQD@1236,3XN54@561,COG1135@1,COG1135@2	NA|NA|NA	P	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C1_03032	316407.4902941	1.8e-84	318.9	Escherichia	metI	GO:0000099,GO:0000101,GO:0003333,GO:0003674,GO:0003824,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015179,GO:0015191,GO:0015238,GO:0015318,GO:0015399,GO:0015405,GO:0015711,GO:0015807,GO:0015821,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042940,GO:0043190,GO:0043492,GO:0043865,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0048473,GO:0050896,GO:0051179,GO:0051234,GO:0055052,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0098533,GO:0098655,GO:0098656,GO:0098796,GO:0098797,GO:1901682,GO:1902475,GO:1902494,GO:1902495,GO:1903825,GO:1904949,GO:1905039,GO:1990351		ko:K02072	ko02010,map02010	M00238			ko00000,ko00001,ko00002,ko02000	3.A.1.24		iPC815.YPO1072	Bacteria	1MW8E@1224,1RPKY@1236,3XN58@561,COG2011@1,COG2011@2	NA|NA|NA	P	Part of the binding-protein-dependent transport system for D-methionine and the toxic methionine analog alpha-methyl- methionine. Probably responsible for the translocation of the substrate across the membrane
C1_03033	198214.SF0188	2.4e-147	528.1	Gammaproteobacteria	metQ	GO:0000101,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0008150,GO:0015711,GO:0015821,GO:0015849,GO:0016020,GO:0016021,GO:0030288,GO:0030313,GO:0031224,GO:0031225,GO:0031226,GO:0031975,GO:0032991,GO:0042597,GO:0042940,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0046658,GO:0046942,GO:0048473,GO:0051179,GO:0051234,GO:0055052,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351		ko:K02072,ko:K02073	ko02010,map02010	M00238			ko00000,ko00001,ko00002,ko02000	3.A.1.24		ic_1306.c0238	Bacteria	1MUVY@1224,1RS3R@1236,COG1464@1,COG1464@2	NA|NA|NA	P	Belongs to the NlpA lipoprotein family
C1_03034	199310.c0237	1.1e-68	265.8	Escherichia	rcsF	GO:0000271,GO:0005575,GO:0005623,GO:0005975,GO:0005976,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009242,GO:0009279,GO:0009987,GO:0016020,GO:0016051,GO:0019867,GO:0023052,GO:0030312,GO:0030313,GO:0031240,GO:0031241,GO:0031975,GO:0033692,GO:0034637,GO:0034645,GO:0035556,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044425,GO:0044462,GO:0044464,GO:0046377,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0071944,GO:0098552,GO:1901135,GO:1901137,GO:1901576		ko:K06080	ko02020,map02020				ko00000,ko00001				Bacteria	1RIKW@1224,1S6DZ@1236,2B4JI@1,31XBN@2,3XPIX@561	NA|NA|NA	M	Essential component of the Rcs signaling system, which controls transcription of numerous genes. Plays a role in signal transduction from the cell surface to the histidine kinase RcsC. May detect outer membrane defects
C1_03035	316407.4902937	1.2e-131	475.7	Escherichia	yaeB	GO:0000049,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016426,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0089715,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363											Bacteria	1MUF0@1224,1RPCX@1236,3XM3F@561,COG1720@1,COG1720@2	NA|NA|NA	S	S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoyladenosine at position 37 (m(6)t(6)A37) of the tRNA anticodon loop of tRNA(Thr)(GGU) that read codons starting with adenosine. The methyl group of m(6)t(6)A37 appears to slightly improve the efficiency of the tRNA decoding ability. Binds to tRNA
C1_03036	198214.SF0185	0.0	1119.4	Gammaproteobacteria	proS	GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004827,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006433,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0043906,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iJN678.proS,iUTI89_1310.UTI89_C0210	Bacteria	1MU7E@1224,1RN5R@1236,COG0442@1,COG0442@2	NA|NA|NA	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
C1_03037	316407.85674378	5.6e-98	363.6	Escherichia	yaeF												Bacteria	1RA8M@1224,1S2BB@1236,3XQMF@561,COG0791@1,COG0791@2	NA|NA|NA	M	cysteine-type peptidase activity
C1_03038	637910.ROD_00481	2.1e-161	575.1	Gammaproteobacteria	piv			ko:K07486					ko00000				Bacteria	1MXKJ@1224,1RSCP@1236,COG3547@1,COG3547@2	NA|NA|NA	L	Transposase
C1_03039	198214.SF0183	5.6e-132	476.9	Gammaproteobacteria	cutF	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008150,GO:0009279,GO:0010810,GO:0016020,GO:0019867,GO:0030155,GO:0030312,GO:0030313,GO:0031975,GO:0042802,GO:0044462,GO:0044464,GO:0050789,GO:0065007,GO:0071944		ko:K06079	ko01503,map01503				ko00000,ko00001				Bacteria	1NZ8R@1224,1S0ZA@1236,COG3015@1,COG3015@2	NA|NA|NA	MP	Copper homeostasis
C1_03040	469008.B21_00189	1.1e-66	259.2	Escherichia	yaeJ	GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0003824,GO:0004045,GO:0005488,GO:0006412,GO:0006414,GO:0006415,GO:0006417,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016150,GO:0016787,GO:0016788,GO:0019222,GO:0019538,GO:0022411,GO:0031323,GO:0031326,GO:0032268,GO:0032984,GO:0034248,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0052689,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0140098,GO:0140101,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112		ko:K15034					ko00000,ko03012				Bacteria	1RH75@1224,1S5YQ@1236,3XPJ1@561,COG1186@1,COG1186@2	NA|NA|NA	J	Rescues stalled ribosomes. Can hydrolyze peptidyl-tRNA on ribosomes stalled by both non-stop mRNAs and mRNAs that contain rare codon clusters or ribosomes stalled in the middle of mRNA. First identified as a complementary ribosome rescue system when the stalled ribosome cannot be rescued by the SsrA(tmRNA)-SmpB quality control system or the alternative ribosome-rescue factor A (arfA)
C1_03041	198214.SF0181	9.6e-100	369.4	Gammaproteobacteria	yaeQ												Bacteria	1RDR9@1224,1S43N@1236,COG4681@1,COG4681@2	NA|NA|NA	S	protein conserved in bacteria
C1_03042	1440052.EAKF1_ch1225	8e-28	129.0	Escherichia	yaeP												Bacteria	1N70N@1224,1SD0N@1236,2E480@1,32Z3X@2,3XQ1N@561	NA|NA|NA	S	Belongs to the UPF0253 family
C1_03043	198214.SF0179	3.7e-41	173.7	Gammaproteobacteria	rof	GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0043244,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141		ko:K19000					ko00000,ko03021				Bacteria	1MZYG@1224,1S8Y7@1236,COG4568@1,COG4568@2	NA|NA|NA	K	Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination
C1_03044	481805.EcolC_3472	1.8e-245	854.7	Escherichia	tilS	GO:0002097,GO:0002101,GO:0002136,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016879,GO:0032267,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	6.3.4.19	ko:K04075,ko:K14058			R09597	RC02633,RC02634	ko00000,ko01000,ko03016				Bacteria	1MU85@1224,1RN14@1236,3XP50@561,COG0037@1,COG0037@2	NA|NA|NA	J	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
C1_03045	155864.EDL933_0192	2e-70	271.6	Escherichia	yaeR			ko:K08234					ko00000				Bacteria	1RGZ8@1224,1S66M@1236,3XPM4@561,COG0346@1,COG0346@2	NA|NA|NA	E	metal ion binding
C1_03046	316407.85674374	0.0	1471.1	Escherichia	ldcC	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004586,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006553,GO:0006554,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0006873,GO:0006885,GO:0008144,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0008792,GO:0008923,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009065,GO:0009066,GO:0009068,GO:0009308,GO:0009309,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016831,GO:0017076,GO:0019001,GO:0019725,GO:0019752,GO:0019842,GO:0030003,GO:0030004,GO:0030170,GO:0030641,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0036094,GO:0042401,GO:0042592,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0045852,GO:0046395,GO:0048037,GO:0048878,GO:0050662,GO:0050801,GO:0051453,GO:0051454,GO:0055067,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0070279,GO:0071704,GO:0097159,GO:0097164,GO:0097216,GO:0097367,GO:0098771,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606	4.1.1.17,4.1.1.18,4.1.1.19	ko:K01581,ko:K01582,ko:K01584,ko:K01585	ko00310,ko00330,ko00480,ko00960,ko01100,ko01110,ko01130,map00310,map00330,map00480,map00960,map01100,map01110,map01130	M00133,M00134	R00462,R00566,R00670	RC00299	ko00000,ko00001,ko00002,ko01000			iEC042_1314.EC042_4483,iEcHS_1320.EcHS_A3126,iSbBS512_1146.SbBS512_E0179	Bacteria	1MWK4@1224,1RMVF@1236,3XP4E@561,COG1982@1,COG1982@2	NA|NA|NA	E	lysine decarboxylase
C1_03047	155864.EDL933_0190	1.3e-176	625.5	Escherichia	accA	GO:0001676,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009317,GO:0009329,GO:0009987,GO:0016053,GO:0019752,GO:0032787,GO:0032991,GO:0042759,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576,GO:1902494,GO:1990234	2.1.3.15,6.4.1.2	ko:K01962,ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000			iAF1260.b0185,iBWG_1329.BWG_0177,iEC55989_1330.EC55989_0179,iECDH10B_1368.ECDH10B_0165,iECDH1ME8569_1439.ECDH1ME8569_0178,iECED1_1282.ECED1_0191,iECH74115_1262.ECH74115_0195,iECIAI1_1343.ECIAI1_0185,iECNA114_1301.ECNA114_0175,iECO111_1330.ECO111_0186,iECO26_1355.ECO26_0187,iECP_1309.ECP_0193,iECSE_1348.ECSE_0184,iECSF_1327.ECSF_0200,iECSP_1301.ECSP_0184,iECW_1372.ECW_m0181,iECs_1301.ECs0187,iEKO11_1354.EKO11_3733,iEcDH1_1363.EcDH1_3418,iEcE24377_1341.EcE24377A_0189,iEcHS_1320.EcHS_A0187,iG2583_1286.G2583_0188,iJN746.PP_1607,iJO1366.b0185,iJR904.b0185,iLF82_1304.LF82_0008,iNRG857_1313.NRG857_00945,iSDY_1059.SDY_0201,iSFV_1184.SFV_0168,iSF_1195.SF0175,iSFxv_1172.SFxv_0185,iS_1188.S0178,iUMNK88_1353.UMNK88_190,iWFL_1372.ECW_m0181,iY75_1357.Y75_RS00935,iZ_1308.Z0197	Bacteria	1MURN@1224,1RNN8@1236,3XMGT@561,COG0825@1,COG0825@2	NA|NA|NA	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
C1_03048	469008.B21_00181	0.0	2317.0	Escherichia	dnaE	GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Bacteria	1MUIF@1224,1RP0K@1236,3XMAZ@561,COG0587@1,COG0587@2	NA|NA|NA	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase
C1_03049	316407.85674372	1.2e-106	392.5	Escherichia	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030				ko00000,ko00001,ko01000,ko03032				Bacteria	1RA65@1224,1RQ4B@1236,3XMIB@561,COG0164@1,COG0164@2	NA|NA|NA	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C1_03050	316407.85674371	7.7e-216	756.1	Escherichia	lpxB	GO:0003674,GO:0003824,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008194,GO:0008289,GO:0008610,GO:0008654,GO:0008915,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0019897,GO:0019898,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005		GT19	iE2348C_1286.E2348C_0187,iEcolC_1368.EcolC_3478,iIT341.HP0867	Bacteria	1MVBI@1224,1RNS1@1236,3XNR7@561,COG0763@1,COG0763@2	NA|NA|NA	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1_03051	198214.SF0171	1.3e-118	432.6	Gammaproteobacteria	lpxA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0008654,GO:0008780,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005			iIT341.HP1375,iPC815.YPO1056	Bacteria	1MUHQ@1224,1RPHB@1236,COG1043@1,COG1043@2	NA|NA|NA	M	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1_03052	1440052.EAKF1_ch1234c	3.2e-80	304.3	Escherichia	fabZ	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0008693,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019171,GO:0019752,GO:0032787,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0047451,GO:0071704,GO:0072330,GO:1901576	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004			iJN746.PP_1602	Bacteria	1RH2T@1224,1S63E@1236,3XMPU@561,COG0764@1,COG0764@2	NA|NA|NA	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
C1_03053	316407.4902920	6.3e-161	573.5	Escherichia	lpxD	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005			ic_1306.c0216	Bacteria	1MUX6@1224,1RNYI@1236,3XP03@561,COG1044@1,COG1044@2	NA|NA|NA	M	Catalyzes the N-acylation of UDP-3-O- (hydroxytetradecanoyl)glucosamine using 3-hydroxytetradecanoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1_03054	155864.EDL933_0183	1.2e-74	285.8	Escherichia	skp	GO:0001530,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006457,GO:0006807,GO:0008104,GO:0008150,GO:0008152,GO:0008289,GO:0009279,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0019867,GO:0022417,GO:0022607,GO:0030288,GO:0030312,GO:0030313,GO:0031647,GO:0031975,GO:0032978,GO:0033036,GO:0034613,GO:0042597,GO:0042802,GO:0043163,GO:0043165,GO:0043170,GO:0044085,GO:0044091,GO:0044238,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0050821,GO:0051082,GO:0051179,GO:0051205,GO:0051234,GO:0051604,GO:0051641,GO:0061024,GO:0061077,GO:0065007,GO:0065008,GO:0070727,GO:0071704,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0097367,GO:1901564		ko:K06142					ko00000				Bacteria	1RD8X@1224,1RQIE@1236,3XMTR@561,COG2825@1,COG2825@2	NA|NA|NA	M	Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm
C1_03055	155864.EDL933_0182	0.0	1646.3	Escherichia	bamA	GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063		ko:K07277					ko00000,ko02000,ko03029	1.B.33			Bacteria	1MU0D@1224,1RMAP@1236,3XNR5@561,COG4775@1,COG4775@2	NA|NA|NA	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery
C1_03056	155864.EDL933_0181	7.6e-255	885.9	Escherichia	rseP	GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016021,GO:0016787,GO:0019219,GO:0019222,GO:0019538,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0043170,GO:0043856,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0045152,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:0140110,GO:1901564,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	3.4.21.107	ko:K04771,ko:K11749	ko01503,ko02020,ko02024,ko04112,map01503,map02020,map02024,map04112	M00728			ko00000,ko00001,ko00002,ko01000,ko01002,ko03110				Bacteria	1MU91@1224,1RMIX@1236,3XNTH@561,COG0750@1,COG0750@2	NA|NA|NA	M	A site-2 regulated intramembrane protease (S2P) that cleaves the peptide bond between 'Ala-108' and 'Cys-109' in the transmembrane region of RseA. Part of a regulated intramembrane proteolysis (RIP) cascade. Acts on DegS-cleaved RseA to release the cytoplasmic domain of RseA
C1_03057	155864.EDL933_0180	2.6e-140	504.6	Escherichia	cdsA	GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0044464,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000			iJN746.PP_1596,iSDY_1059.SDY_0191	Bacteria	1MWSV@1224,1RQ6M@1236,3XP45@561,COG0575@1,COG0575@2	NA|NA|NA	I	Belongs to the CDS family
C1_03059	155864.EDL933_0178	1.4e-141	508.8	Escherichia	uppS	GO:0000270,GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006066,GO:0006629,GO:0006720,GO:0006807,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008834,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030203,GO:0034645,GO:0042546,GO:0043164,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110		R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006			iECBD_1354.ECBD_3445,iECOK1_1307.ECOK1_0175,iECSE_1348.ECSE_0173,iECW_1372.ECW_m0170,iEKO11_1354.EKO11_3744,iEcDH1_1363.EcDH1_3429,iEcE24377_1341.EcE24377A_0178,iEcHS_1320.EcHS_A0176,iNRG857_1313.NRG857_00890,iSFV_1184.SFV_0157,iUMN146_1321.UM146_23675,iUMNK88_1353.UMNK88_178,iWFL_1372.ECW_m0170,iY75_1357.Y75_RS00880	Bacteria	1MVP1@1224,1RMVX@1236,3XP81@561,COG0020@1,COG0020@2	NA|NA|NA	I	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide
C1_03060	316407.85674366	1.1e-220	772.3	Escherichia	dxr	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0050897,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_1814,iECOK1_1307.ECOK1_0174,iECS88_1305.ECS88_0183,iHN637.CLJU_RS06420,iNJ661.Rv2870c,iUMN146_1321.UM146_23670,iUTI89_1310.UTI89_C0188	Bacteria	1MU4G@1224,1RNNW@1236,3XNDF@561,COG0743@1,COG0743@2	NA|NA|NA	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)
C1_03061	155864.EDL933_0176	4.9e-91	340.5	Escherichia	frr	GO:0002181,GO:0002184,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0030312,GO:0032984,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576		ko:K02838					ko00000,ko03012				Bacteria	1N66T@1224,1RN75@1236,3XNVW@561,COG0233@1,COG0233@2	NA|NA|NA	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
C1_03062	155864.EDL933_0175	5.3e-130	470.3	Escherichia	pyrH	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0033862,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100		R00158	RC00002	ko00000,ko00001,ko01000				Bacteria	1MV3N@1224,1RMHX@1236,3XP3X@561,COG0528@1,COG0528@2	NA|NA|NA	F	Catalyzes the reversible phosphorylation of UMP to UDP
C1_03063	1440052.EAKF1_ch1244c	2.7e-149	534.6	Escherichia	tsf	GO:0001871,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005085,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0019538,GO:0019899,GO:0030246,GO:0030247,GO:0034641,GO:0034645,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051020,GO:0065007,GO:0065009,GO:0071704,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065		ko:K02357					ko00000,ko03012,ko03029				Bacteria	1MUS2@1224,1RPBJ@1236,3XNI1@561,COG0264@1,COG0264@2	NA|NA|NA	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C1_03064	1440052.EAKF1_ch1245c	2.8e-131	474.6	Escherichia	rpsB	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02967	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1MU33@1224,1RN0Z@1236,3XMCP@561,COG0052@1,COG0052@2	NA|NA|NA	J	ribosomal protein
C1_03065	155864.EDL933_0171	1.8e-150	538.5	Escherichia	map	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0140096,GO:1901564	3.4.11.18	ko:K01265					ko00000,ko01000,ko01002				Bacteria	1MU99@1224,1RMHN@1236,3XMB7@561,COG0024@1,COG0024@2	NA|NA|NA	E	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed
C1_03066	469008.B21_00164	0.0	1781.9	Escherichia	glnD	GO:0003674,GO:0003824,GO:0006082,GO:0006355,GO:0006464,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0006808,GO:0007154,GO:0007584,GO:0008150,GO:0008152,GO:0008652,GO:0008773,GO:0009058,GO:0009064,GO:0009084,GO:0009605,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0018175,GO:0018177,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0045893,GO:0045935,GO:0046394,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070569,GO:0070887,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0080090,GO:0090293,GO:0140096,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901698,GO:1901699,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	2.7.7.59	ko:K00990	ko02020,map02020				ko00000,ko00001,ko01000				Bacteria	1MV54@1224,1RN5T@1236,3XMIM@561,COG2844@1,COG2844@2	NA|NA|NA	O	in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C1_03067	198214.SF0156	7.4e-136	490.0	Gammaproteobacteria	dapD	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008666,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009987,GO:0016053,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016749,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.117,2.3.1.89	ko:K00674,ko:K05822	ko00300,ko01100,ko01110,ko01120,ko01230,map00300,map01100,map01110,map01120,map01230	M00016,M00525	R04364,R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000			iSbBS512_1146.SbBS512_E0158,iYO844.BSU14180	Bacteria	1MU0Y@1224,1RPCS@1236,COG2171@1,COG2171@2	NA|NA|NA	E	Belongs to the transferase hexapeptide repeat family
C1_03068	1440052.EAKF1_ch1250	2.7e-64	251.1	Escherichia	yaeH												Bacteria	1RD2V@1224,1S3XU@1236,28NXJ@1,2ZBV4@2,3XPIG@561	NA|NA|NA	S	Belongs to the UPF0325 family
C1_03069	362663.ECP_0172	3e-215	754.2	Escherichia	cdaR	GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141		ko:K02647					ko00000,ko03000				Bacteria	1NJZ9@1224,1RMEP@1236,3XNXX@561,COG3835@1,COG3835@2	NA|NA|NA	K	diacid regulator
C1_03070	155864.EDL933_0166	1.8e-254	884.8	Escherichia	degP	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006457,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016020,GO:0016787,GO:0017171,GO:0019538,GO:0030163,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044464,GO:0050896,GO:0051603,GO:0061077,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575	1.3.1.74,3.4.21.107	ko:K04771,ko:K04772,ko:K08070	ko01503,ko02020,map01503,map02020	M00728			ko00000,ko00001,ko00002,ko01000,ko01002,ko03110				Bacteria	1MU63@1224,1RN9T@1236,3XMGW@561,COG0265@1,COG0265@2	NA|NA|NA	O	DegP acts as a chaperone at low temperatures but switches to a peptidase (heat shock protein) at higher temperatures. Degrades transiently denatured and unfolded or misfolded proteins which accumulate in the periplasm following heat shock or other stress conditions. DegP is efficient with Val-Xaa and Ile-Xaa peptide bonds, suggesting a preference for beta-branched side chain amino acids. Only unfolded proteins devoid of disulfide bonds appear capable of being cleaved, thereby preventing non-specific proteolysis of folded proteins. Its proteolytic activity is essential for the survival of cells at elevated temperatures. It can degrade IciA, Ada, casein, globin and PapA. DegP shares specificity with DegQ. DegP is also involved in the biogenesis of partially folded outer-membrane proteins (OMP)
C1_03071	469008.B21_00158	9e-297	1025.4	Escherichia	dgt	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0015949,GO:0016462,GO:0016787,GO:0016788,GO:0016793,GO:0016817,GO:0016818,GO:0017111,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0030145,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0050897,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0097159,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576	3.1.5.1	ko:K01129	ko00230,map00230		R01856	RC00017	ko00000,ko00001,ko01000			iSF_1195.SF0152	Bacteria	1MVQ2@1224,1RPVJ@1236,3XMKE@561,COG0232@1,COG0232@2	NA|NA|NA	F	dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs
C1_03072	155864.EDL933_0164	2.2e-125	454.9	Escherichia	mtnN	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008477,GO:0008652,GO:0008782,GO:0008930,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009116,GO:0009119,GO:0009987,GO:0016053,GO:0016787,GO:0016798,GO:0016799,GO:0017144,GO:0019284,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0042802,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046394,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071265,GO:0071267,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901657	3.2.2.9	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00034,M00609	R00194,R01401	RC00063,RC00318	ko00000,ko00001,ko00002,ko01000			iPC815.YPO3384,iSBO_1134.SBO_0148	Bacteria	1MY5S@1224,1RNSF@1236,3XNQB@561,COG0775@1,COG0775@2	NA|NA|NA	F	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C1_03073	316407.85674362	3.1e-147	527.7	Escherichia	btuF	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0008144,GO:0008150,GO:0015889,GO:0015893,GO:0019842,GO:0030288,GO:0030313,GO:0031419,GO:0031975,GO:0036094,GO:0042221,GO:0042493,GO:0042597,GO:0044464,GO:0046906,GO:0048037,GO:0050896,GO:0051179,GO:0051180,GO:0051181,GO:0051234,GO:0071702,GO:0071705,GO:0097159,GO:1901363		ko:K02016,ko:K06858	ko02010,map02010	M00240,M00241			ko00000,ko00001,ko00002,ko02000	3.A.1.13,3.A.1.14		iECH74115_1262.ECH74115_0168,iECSP_1301.ECSP_0159,iECs_1301.ECs0162,iZ_1308.Z0169	Bacteria	1MWVF@1224,1RMV8@1236,3XNJV@561,COG0614@1,COG0614@2	NA|NA|NA	P	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC
C1_03074	199310.c0193	2.9e-108	397.9	Escherichia	yadS	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1RHQN@1224,1S5YY@1236,3XNQY@561,COG2860@1,COG2860@2	NA|NA|NA	S	UPF0126 domain
C1_03075	155864.EDL933_0161	8.9e-59	232.6	Escherichia	erpA	GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009061,GO:0009987,GO:0010467,GO:0015980,GO:0016020,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055114,GO:0071704,GO:0071840,GO:0071944,GO:1901564		ko:K13628,ko:K15724					ko00000,ko03016				Bacteria	1RHCW@1224,1S675@1236,3XPP3@561,COG0316@1,COG0316@2	NA|NA|NA	C	Probably involved in the insertion of Fe-S clusters into apoproteins in vivo including IspG and or IspH. Essential for growth under aerobic conditions and for anaerobic respiration but not for fermentation. In vitro it binds Fe-S clusters and transfers them to apo-IspG, which is involved in quinone biosynthesis among many other cell components. Experiments indicate that it is probably also involved in the insertion of other Fe-S clusters than IspG IspH
C1_03076	316407.85674361	2e-258	897.9	Escherichia	clcA	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006821,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015672,GO:0015698,GO:0015706,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0031404,GO:0034220,GO:0042802,GO:0043167,GO:0043168,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071705,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600		ko:K03281					ko00000	2.A.49		iAF1260.b0155,iB21_1397.B21_00153,iBWG_1329.BWG_0148,iE2348C_1286.E2348C_0162,iEC042_1314.EC042_0155,iEC55989_1330.EC55989_0149,iECBD_1354.ECBD_3463,iECDH10B_1368.ECDH10B_0135,iECDH1ME8569_1439.ECDH1ME8569_0149,iECD_1391.ECD_00154,iECIAI1_1343.ECIAI1_0153,iECO103_1326.ECO103_0155,iECSE_1348.ECSE_0156,iECUMN_1333.ECUMN_0152,iECW_1372.ECW_m0152,iEKO11_1354.EKO11_3761,iETEC_1333.ETEC_0151,iEcDH1_1363.EcDH1_3447,iEcE24377_1341.EcE24377A_0160,iEcolC_1368.EcolC_3504,iJO1366.b0155,iSSON_1240.SSON_0167,iUMNK88_1353.UMNK88_159,iWFL_1372.ECW_m0152,iY75_1357.Y75_RS00790,iZ_1308.Z0166	Bacteria	1MV4K@1224,1RQJW@1236,3XPHI@561,COG0038@1,COG0038@2	NA|NA|NA	P	proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response
C1_03077	469008.B21_00152	5.5e-247	859.8	Escherichia	hemL	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016853,GO:0016866,GO:0016869,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042286,GO:0042440,GO:0042802,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007			iSB619.SA_RS08395,iUMNK88_1353.UMNK88_158	Bacteria	1MUY5@1224,1RM7N@1236,3XNJF@561,COG0001@1,COG0001@2	NA|NA|NA	H	glutamate-1-semialdehyde 2,1-aminomutase activity
C1_03078	469008.B21_00151	0.0	1233.4	Escherichia	fhuB	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351		ko:K02015	ko02010,map02010	M00240			ko00000,ko00001,ko00002,ko02000	3.A.1.14		iB21_1397.B21_04117,iEC042_1314.EC042_4777,iEC55989_1330.EC55989_4961,iEC55989_1330.EC55989_4962,iECABU_c1320.ECABU_c49000,iECBD_1354.ECBD_3750,iECB_1328.ECB_04154,iECD_1391.ECD_04154,iECED1_1282.ECED1_5153,iECH74115_1262.ECH74115_0675,iECIAI39_1322.ECIAI39_4767,iECNA114_1301.ECNA114_2547,iECO103_1326.ECO103_0598,iECO26_1355.ECO26_5456,iECP_1309.ECP_0163,iECSP_1301.ECSP_0644,iECUMN_1333.ECUMN_0684,iECs_1301.ECs0629,iEcE24377_1341.EcE24377A_4865,iEcE24377_1341.EcE24377A_4866,iEcHS_1320.EcHS_A0641,iEcolC_1368.EcolC_0740,iG2583_1286.G2583_0753,iSBO_1134.SBO_0451,iSFV_1184.SFV_0538,iSbBS512_1146.SbBS512_E0492,iUMNK88_1353.UMNK88_5227,iZ_1308.Z0732	Bacteria	1MVA3@1224,1RN0J@1236,3XMUG@561,COG0609@1,COG0609@2	NA|NA|NA	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1_03079	316407.85674358	2.5e-169	601.3	Escherichia	fhuD	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464		ko:K02016	ko02010,map02010	M00240			ko00000,ko00001,ko00002,ko02000	3.A.1.14		iAPECO1_1312.APECO1_1833,iEC042_1314.EC042_0152,iECABU_c1320.ECABU_c01660,iECNA114_1301.ECNA114_0143,iECOK1_1307.ECOK1_0155,iECS88_1305.ECS88_0163,iECSF_1327.ECSF_0169,iLF82_1304.LF82_0653,iNRG857_1313.NRG857_00790,iSDY_1059.SDY_0168,iUMN146_1321.UM146_23575	Bacteria	1PEJ1@1224,1RNIS@1236,3XN97@561,COG0614@1,COG0614@2	NA|NA|NA	P	Part of the ABC transporter complex FhuCDB involved in iron(3 )-hydroxamate import. Binds the iron(3 )-hydroxamate complex and transfers it to the membrane-bound permease. Required for the transport of all iron(3 )-hydroxamate siderophores such as ferrichrome, gallichrome, desferrioxamine, coprogen, aerobactin, shizokinen, rhodotorulic acid and the antibiotic albomycin
C1_03080	155864.EDL933_0156	8.2e-148	529.6	Escherichia	fhuC	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0016021,GO:0017076,GO:0030554,GO:0031224,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0097159,GO:0097367,GO:0098533,GO:0098796,GO:0098797,GO:1901265,GO:1901363,GO:1902494,GO:1902495,GO:1904949,GO:1990351	3.6.3.34	ko:K02013	ko02010,map02010	M00240			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14		iE2348C_1286.E2348C_0490,iECABU_c1320.ECABU_c06380,iECED1_1282.ECED1_0585,iECNA114_1301.ECNA114_0142,iECNA114_1301.ECNA114_0531,iECOK1_1307.ECOK1_0599,iECP_1309.ECP_0620,iECS88_1305.ECS88_0627,iECSF_1327.ECSF_0168,iECSF_1327.ECSF_0529,iLF82_1304.LF82_0642,iNRG857_1313.NRG857_02665,iPC815.YPO3392,iUMN146_1321.UM146_14565,iUTI89_1310.UTI89_C0590,ic_1306.c0675	Bacteria	1MUNG@1224,1RQ6C@1236,3XNM1@561,COG1120@1,COG1120@2	NA|NA|NA	P	Part of the ABC transporter complex FhuCDB involved in iron(3 )-hydroxamate import. Responsible for energy coupling to the transport system
C1_03081	316407.85674356	0.0	1505.3	Escherichia	fhuA	GO:0003674,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005623,GO:0009279,GO:0015643,GO:0016020,GO:0019867,GO:0019904,GO:0030312,GO:0030313,GO:0031975,GO:0043167,GO:0043169,GO:0044462,GO:0044464,GO:0046790,GO:0046872,GO:0046914,GO:0048037,GO:0071944		ko:K02014					ko00000,ko02000	1.B.14		iECSE_1348.ECSE_0151,iECW_1372.ECW_m0147,iEKO11_1354.EKO11_3766,iEcolC_1368.EcolC_3509,iWFL_1372.ECW_m0147	Bacteria	1MV0X@1224,1T1GW@1236,3XM9E@561,COG4774@1,COG4774@2	NA|NA|NA	P	Involved in the uptake of iron in complex with ferrichrome, an hydroxamate-type siderophore. Binds and transports ferrichrome-iron across the outer membrane. In addition to its role in ferrichrome-iron transport, transports the antibiotic albomycin, which is a structural analog of ferrichrome, and acts as a receptor for colicin M, microcin J25 and bacteriophages T1, T5, phi80 and UC-1. The energy source, which is required for all FhuA functions except infection by phage T5, is provided by the inner membrane TonB system
C1_03082	198214.SF0141	0.0	1577.0	Gammaproteobacteria	mrcB	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008289,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031406,GO:0031975,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042277,GO:0042546,GO:0042597,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071723,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681	2.4.1.129,3.4.16.4	ko:K05365	ko00550,map00550		R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011		GT51	iECIAI39_1322.ECIAI39_0153,iSBO_1134.SBO_0138,iSbBS512_1146.SbBS512_E0140,iYL1228.KPN_00164	Bacteria	1QTST@1224,1RNHV@1236,COG0744@1,COG0744@2	NA|NA|NA	M	Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
C1_03083	469008.B21_00146	0.0	1554.3	Escherichia	hrpB		3.6.4.13	ko:K03579					ko00000,ko01000				Bacteria	1MUEQ@1224,1RR1B@1236,3XN52@561,COG1643@1,COG1643@2	NA|NA|NA	L	ATP-dependent helicase activity
C1_03084	316407.85674353	5.1e-98	363.6	Escherichia	ligT	GO:0003674,GO:0003824,GO:0004112,GO:0004113,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008081,GO:0008104,GO:0008150,GO:0008452,GO:0008664,GO:0009966,GO:0010646,GO:0010738,GO:0016787,GO:0016788,GO:0016874,GO:0016886,GO:0023051,GO:0033036,GO:0034237,GO:0042578,GO:0044424,GO:0044444,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0051018,GO:0051179,GO:0065007,GO:0140098,GO:1902531	3.1.4.58,3.5.1.42	ko:K01975,ko:K03743	ko00760,map00760		R02322	RC00100	ko00000,ko00001,ko01000,ko03016				Bacteria	1RDB2@1224,1SCZX@1236,3XMSE@561,COG1514@1,COG1514@2	NA|NA|NA	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C1_03085	155864.EDL933_0150	9.8e-129	466.1	Escherichia	sfsA	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005975,GO:0006355,GO:0008150,GO:0008152,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0044238,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141		ko:K06206					ko00000				Bacteria	1MUC3@1224,1RQ95@1236,3XMFH@561,COG1489@1,COG1489@2	NA|NA|NA	K	Binds to DNA non-specifically. Could be a regulatory factor involved in maltose metabolism
C1_03086	1073999.BN137_3015	3e-78	297.7	Gammaproteobacteria	dksA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K06204	ko02026,map02026				ko00000,ko00001,ko03000,ko03009,ko03021				Bacteria	1RD08@1224,1S47H@1236,COG1734@1,COG1734@2	NA|NA|NA	T	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression
C1_03087	316407.85674352	3.2e-180	637.5	Escherichia	gluQ	GO:0000166,GO:0002097,GO:0003674,GO:0005488,GO:0005524,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363		ko:K01894					ko00000,ko01000,ko01007,ko03016				Bacteria	1MUN7@1224,1RMYQ@1236,3XN6X@561,COG0008@1,COG0008@2	NA|NA|NA	J	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon
C1_03088	155864.EDL933_0147	1.4e-259	901.7	Escherichia	pcnB	GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004652,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006276,GO:0006378,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0031123,GO:0031124,GO:0034641,GO:0043170,GO:0043412,GO:0043631,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070566,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018		R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019				Bacteria	1MVCS@1224,1RMBG@1236,3XNZM@561,COG0617@1,COG0617@2	NA|NA|NA	F	Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control
C1_03089	469008.B21_00140	7.7e-85	319.7	Escherichia	folK	GO:0000287,GO:0003674,GO:0003824,GO:0003848,GO:0005488,GO:0016740,GO:0016772,GO:0016778,GO:0043167,GO:0043169,GO:0046872	2.7.6.3,4.1.2.25	ko:K00950,ko:K13940	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503,R03504	RC00002,RC00017,RC00721,RC00943	ko00000,ko00001,ko00002,ko01000			iECDH1ME8569_1439.ECDH1ME8569_0136,iEcDH1_1363.EcDH1_3460,iJN746.PP_4698,iSBO_1134.SBO_0131	Bacteria	1MZH8@1224,1S63J@1236,3XMN2@561,COG0801@1,COG0801@2	NA|NA|NA	H	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
C1_03090	316407.85674350	4.2e-101	374.0	Escherichia	yadN	GO:0005575,GO:0005623,GO:0007155,GO:0008150,GO:0009289,GO:0022610,GO:0042995,GO:0044464											Bacteria	1RGR4@1224,1S3WW@1236,3XR3J@561,COG3539@1,COG3539@2	NA|NA|NA	NU	Part of the yadCKLM-htrE-yadVN fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches
C1_03091	469008.B21_00138	1.8e-136	491.9	Escherichia	ecpD	GO:0007155,GO:0008150,GO:0009987,GO:0016043,GO:0022610,GO:0030030,GO:0043711,GO:0071840		ko:K07346,ko:K07353,ko:K15540					ko00000,ko02035,ko02044,ko03110				Bacteria	1MY06@1224,1RR9H@1236,3XRFS@561,COG3121@1,COG3121@2	NA|NA|NA	M	Part of the yadCKLM-htrE-yadVN fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches
C1_03092	469008.B21_00137	0.0	1723.0	Escherichia	htrE	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0009279,GO:0009297,GO:0009987,GO:0015267,GO:0015288,GO:0015473,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0022803,GO:0022829,GO:0022857,GO:0030030,GO:0030031,GO:0030312,GO:0030313,GO:0031975,GO:0043711,GO:0044085,GO:0044462,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071840,GO:0071944		ko:K07347	ko05133,map05133				ko00000,ko00001,ko02000,ko02035,ko02044	1.B.11.3			Bacteria	1MUHE@1224,1RMPU@1236,3XQED@561,COG3188@1,COG3188@2	NA|NA|NA	M	outer membrane usher protein
C1_03093	469008.B21_00136	9.4e-98	362.8	Escherichia	yadM	GO:0007155,GO:0008150,GO:0022610		ko:K07345	ko05133,map05133				ko00000,ko00001,ko02035,ko02044				Bacteria	1N055@1224,1SBJ2@1236,3XR2W@561,COG3539@1,COG3539@2	NA|NA|NA	NU	Part of the yadCKLM-htrE-yadVN fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches
C1_03094	469008.B21_00135	5.3e-99	367.1	Escherichia	yadL												Bacteria	1RJYB@1224,1S7ET@1236,3XR7D@561,COG3539@1,COG3539@2	NA|NA|NA	NU	Part of the yadCKLM-htrE-yadVN fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches
C1_03095	469008.B21_00134	3.4e-106	391.0	Escherichia	yadK	GO:0005575,GO:0005623,GO:0007155,GO:0008150,GO:0009289,GO:0009987,GO:0022610,GO:0031589,GO:0042710,GO:0042995,GO:0043708,GO:0043709,GO:0044010,GO:0044464,GO:0044764,GO:0051704,GO:0090605,GO:0090609											Bacteria	1NZBZ@1224,1SQYM@1236,3XR5S@561,COG3539@1,COG3539@2	NA|NA|NA	NU	Part of the yadCKLM-htrE-yadVN fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches
C1_03096	469008.B21_00133	8.5e-248	862.4	Escherichia	yadC	GO:0005575,GO:0005623,GO:0006950,GO:0006974,GO:0007155,GO:0008150,GO:0009289,GO:0009987,GO:0022610,GO:0031589,GO:0033554,GO:0042221,GO:0042710,GO:0042995,GO:0043708,GO:0043709,GO:0044010,GO:0044464,GO:0044764,GO:0046677,GO:0050896,GO:0051704,GO:0051716,GO:0090605,GO:0090609		ko:K07350					ko00000,ko02035,ko02044				Bacteria	1NKD6@1224,1SIJ1@1236,3XR4K@561,COG3539@1,COG3539@2	NA|NA|NA	NU	Fimbrial protein
C1_03097	469008.B21_00132	9.3e-144	516.2	Escherichia	panB	GO:0000287,GO:0003674,GO:0003824,GO:0003864,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016740,GO:0016741,GO:0016742,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000			iB21_1397.B21_00132,iE2348C_1286.E2348C_0137,iECBD_1354.ECBD_3485,iECB_1328.ECB_00133,iECD_1391.ECD_00133,iPC815.YPO3401	Bacteria	1MU3B@1224,1RM8D@1236,3XNWS@561,COG0413@1,COG0413@2	NA|NA|NA	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate
C1_03098	316407.85674348	3.7e-154	550.8	Escherichia	panC	GO:0003674,GO:0003824,GO:0004592,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000			iECH74115_1262.ECH74115_0142,iECSP_1301.ECSP_0134,iECs_1301.ECs0137,iG2583_1286.G2583_0137,iZ_1308.Z0144	Bacteria	1MV1S@1224,1RMEG@1236,3XMDV@561,COG0414@1,COG0414@2	NA|NA|NA	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C1_03099	316407.85674347	3.2e-154	551.2	Escherichia	yadD	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1990238											Bacteria	1MUSP@1224,1RNUW@1236,3XQBX@561,COG5464@1,COG5464@2	NA|NA|NA	L	Upon expression enhances RecA-independent DNA recombination 2.9-fold, concomitantly reducing viability by 59 and inducing DNA damage as measured by induction of the SOS repair response
C1_03100	155864.EDL933_0134	7e-65	253.1	Escherichia	panD	GO:0003674,GO:0003824,GO:0004068,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006508,GO:0006520,GO:0006522,GO:0006523,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009078,GO:0009079,GO:0009108,GO:0009110,GO:0009987,GO:0010467,GO:0015939,GO:0015940,GO:0016053,GO:0016485,GO:0016540,GO:0016829,GO:0016830,GO:0016831,GO:0019538,GO:0019752,GO:0030312,GO:0032787,GO:0034641,GO:0042364,GO:0042398,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0071944,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.1.1.11	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R00489	RC00299	ko00000,ko00001,ko00002,ko01000			iECP_1309.ECP_0139,iYL1228.KPN_00139	Bacteria	1RI1B@1224,1S66E@1236,3XPIJ@561,COG0853@1,COG0853@2	NA|NA|NA	H	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C1_03101	316407.85674345	2.3e-234	817.8	Escherichia	yadE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016787,GO:0016810,GO:0016814,GO:0044424,GO:0044444,GO:0044464	3.5.1.41	ko:K01452	ko00520,ko01100,map00520,map01100		R02333	RC00166,RC00300	ko00000,ko00001,ko01000				Bacteria	1MWR2@1224,1RP7J@1236,3XP5Q@561,COG0726@1,COG0726@2	NA|NA|NA	G	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
C1_03102	316407.85674344	6.9e-80	303.1	Escherichia	yadI			ko:K02744	ko00052,ko02060,map00052,map02060	M00277,M00287	R08366,R08367	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.6.1.4,4.A.6.1.5			Bacteria	1RA6P@1224,1S2FN@1236,3XPNF@561,COG2893@1,COG2893@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane
C1_03103	198214.SF0125	4.3e-138	497.3	Gammaproteobacteria	yadH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K01992		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	1MUH1@1224,1RP0Z@1236,COG0842@1,COG0842@2	NA|NA|NA	V	Transport Permease Protein
C1_03104	316407.21238982	2.2e-168	598.2	Escherichia	yadG	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0016020,GO:0044464,GO:0050896,GO:0071944		ko:K01990,ko:K09695	ko02010,map02010	M00252,M00254			ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102			Bacteria	1MUW7@1224,1RMC5@1236,3XMIT@561,COG1131@1,COG1131@2	NA|NA|NA	V	ABC transporter, ATP-binding protein
C1_03105	198214.SF0123	3.3e-126	457.6	Gammaproteobacteria	can	GO:0003674,GO:0003824,GO:0004089,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008270,GO:0015976,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914	4.2.1.1	ko:K01673	ko00910,map00910		R00132,R10092	RC02807	ko00000,ko00001,ko01000			iNJ661.Rv3273,iSBO_1134.SBO_0115,iSbBS512_1146.SbBS512_E0119	Bacteria	1NGFN@1224,1RSY6@1236,COG0288@1,COG0288@2	NA|NA|NA	P	Reversible hydration of carbon dioxide
C1_03106	155864.EDL933_0128	1e-93	349.4	Escherichia	hpt	GO:0000287,GO:0003674,GO:0003824,GO:0004422,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006166,GO:0006177,GO:0006188,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032261,GO:0032263,GO:0032264,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0043094,GO:0043101,GO:0043167,GO:0043169,GO:0043173,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046040,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110		R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000				Bacteria	1NRT8@1224,1RNPQ@1236,3XP65@561,COG0634@1,COG0634@2	NA|NA|NA	F	Belongs to the purine pyrimidine phosphoribosyltransferase family
C1_03107	155864.EDL933_0127	0.0	1598.9	Escherichia	gcd	GO:0000287,GO:0003674,GO:0003824,GO:0004344,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0008876,GO:0016020,GO:0016021,GO:0016491,GO:0016614,GO:0016901,GO:0019842,GO:0031224,GO:0031406,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044425,GO:0044464,GO:0046872,GO:0048037,GO:0048038,GO:0048039,GO:0055114,GO:0070968,GO:0071944,GO:0097159,GO:1901363	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130		R06620	RC00066	ko00000,ko00001,ko01000			iEC55989_1330.EC55989_0117,iECIAI1_1343.ECIAI1_0122,iECW_1372.ECW_m0121,iEKO11_1354.EKO11_3792,iWFL_1372.ECW_m0121	Bacteria	1MUQX@1224,1RN5D@1236,3XPH2@561,COG4993@1,COG4993@2	NA|NA|NA	G	Glucose dehydrogenase
C1_03108	316407.85674340	6.4e-298	1029.2	Escherichia	cueO	GO:0003674,GO:0003824,GO:0004322,GO:0005488,GO:0005507,GO:0005575,GO:0005623,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0010038,GO:0010212,GO:0010273,GO:0016491,GO:0016679,GO:0016682,GO:0016722,GO:0016724,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0046688,GO:0046872,GO:0046914,GO:0050896,GO:0051301,GO:0055114,GO:0061687,GO:0097501,GO:0098754,GO:1990169		ko:K04753,ko:K14588					ko00000			iECH74115_1262.ECH74115_0130,iECSP_1301.ECSP_0124,iSbBS512_1146.SbBS512_E0116	Bacteria	1MU0J@1224,1RQ4N@1236,3XNI6@561,COG2132@1,COG2132@2	NA|NA|NA	Q	Probably involved in periplasmic detoxification of copper by oxidizing Cu( ) to Cu(2 ) and thus preventing its uptake into the cytoplasm. Possesses phenoloxidase and ferroxidase activities and might be involved in the production of polyphenolic compounds and the prevention of oxidative damage in the periplasm
C1_03109	155864.EDL933_0124	1.6e-51	208.4	Escherichia	yacC												Bacteria	1RH3T@1224,1S639@1236,2B1X9@1,31UDJ@2,3XPRS@561	NA|NA|NA	S	Type II secretion system pilotin lipoprotein (PulS_OutS)
C1_03110	316407.21238974	2e-168	598.2	Escherichia	speE	GO:0003674,GO:0003824,GO:0004766,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0010487,GO:0016740,GO:0016765,GO:0034641,GO:0042401,GO:0043918,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000			iECED1_1282.ECED1_0125,iPC815.YPO3411,iSDY_1059.SDY_0028	Bacteria	1MVV5@1224,1RMUT@1236,3XPDB@561,COG0421@1,COG0421@2	NA|NA|NA	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C1_03111	155864.EDL933_0122	1.9e-152	545.0	Escherichia	speD	GO:0003674,GO:0003824,GO:0004014,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576	2.5.1.16,4.1.1.50	ko:K00797,ko:K01611	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R00178,R01920,R02869,R08359	RC00021,RC00053,RC00299	ko00000,ko00001,ko00002,ko01000			iPC815.YPO3412,iSDY_1059.SDY_0027	Bacteria	1MXPT@1224,1RQSX@1236,3XMVM@561,COG1586@1,COG1586@2	NA|NA|NA	F	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C1_03112	155864.EDL933_0121	8.2e-63	246.1	Escherichia	yacL			ko:K09910					ko00000				Bacteria	1RH38@1224,1S6EG@1236,3XPS8@561,COG3112@1,COG3112@2	NA|NA|NA	S	Belongs to the UPF0231 family
C1_03113	316407.85674339	0.0	1729.9	Escherichia	acnB	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006417,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009060,GO:0009062,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0010608,GO:0015980,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017001,GO:0017144,GO:0019222,GO:0019541,GO:0019543,GO:0019626,GO:0019629,GO:0019752,GO:0031323,GO:0031326,GO:0032268,GO:0032787,GO:0034248,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046395,GO:0046459,GO:0046487,GO:0047456,GO:0048037,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0060255,GO:0065007,GO:0071704,GO:0072329,GO:0072350,GO:0080090,GO:0097159,GO:1901363,GO:1901575,GO:2000112	4.2.1.3,4.2.1.99	ko:K01682	ko00020,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173	R01324,R01325,R01900,R04425	RC00497,RC00498,RC00618,RC01153	br01601,ko00000,ko00001,ko00002,ko01000			iECIAI1_1343.ECIAI1_0116,iPC815.YPO3415	Bacteria	1MVCR@1224,1RNMC@1236,3XP43@561,COG1049@1,COG1049@2	NA|NA|NA	C	Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. Also catalyzes the hydration of 2-methyl-cis- aconitate to yield (2R,3S)-2-methylisocitrate. The apo form of AcnB functions as a RNA-binding regulatory protein. During oxidative stress inactive AcnB apo-enzyme without iron sulfur clusters binds the acnB mRNA 3' UTRs (untranslated regions), stabilizes acnB mRNA and increases AcnB synthesis, thus mediating a post-transcriptional positive autoregulatory switch. AcnB also decreases the stability of the sodA transcript
C1_03114	481805.EcolC_3542	2.3e-251	874.8	Escherichia	yacH												Bacteria	1MXPS@1224,1RQIV@1236,3XNHJ@561,COG3064@1,COG3064@2	NA|NA|NA	M	Protein of unknown function (DUF3300)
C1_03115	155864.EDL933_0118	2.7e-271	940.6	Escherichia	lpdA	GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0004148,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006103,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006520,GO:0006544,GO:0006546,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009058,GO:0009063,GO:0009069,GO:0009071,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015036,GO:0016054,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0017144,GO:0018130,GO:0018335,GO:0019362,GO:0019438,GO:0019464,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036094,GO:0036211,GO:0042133,GO:0042135,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0043648,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0045250,GO:0045252,GO:0045254,GO:0046390,GO:0046395,GO:0046483,GO:0046496,GO:0046872,GO:0046914,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0065007,GO:0065008,GO:0070013,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0097159,GO:0106077,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1902494,GO:1990204,GO:1990234	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147			iAPECO1_1312.APECO1_1869,iEcolC_1368.EcolC_3543,iPC815.YPO3417,iSFV_1184.SFV_0107,iUMN146_1321.UM146_23385	Bacteria	1MU2U@1224,1RMFF@1236,3XM8F@561,COG1249@1,COG1249@2	NA|NA|NA	F	Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes
C1_03116	316407.21238964	0.0	1103.2	Escherichia	aceF	GO:0003674,GO:0003824,GO:0004742,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016407,GO:0016417,GO:0016418,GO:0016740,GO:0016746,GO:0016747,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030523,GO:0031405,GO:0031406,GO:0032787,GO:0032991,GO:0033293,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045254,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1902494,GO:1990204	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000			iETEC_1333.ETEC_0111,iSSON_1240.SSON_0123,iYL1228.KPN_00119	Bacteria	1MU7K@1224,1RNPT@1236,3XP11@561,COG0508@1,COG0508@2	NA|NA|NA	F	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C1_03117	155864.EDL933_0116	0.0	1800.4	Escherichia	aceE	GO:0000287,GO:0003674,GO:0003824,GO:0004738,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0019842,GO:0030976,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0046872,GO:0046983,GO:0048037,GO:0050662,GO:0055114,GO:0097159,GO:1901363,GO:1901681	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000			e_coli_core.b0114,iAF1260.b0114,iBWG_1329.BWG_0107,iE2348C_1286.E2348C_0117,iEC55989_1330.EC55989_0107,iECDH10B_1368.ECDH10B_0094,iECDH1ME8569_1439.ECDH1ME8569_0108,iECH74115_1262.ECH74115_0121,iECIAI1_1343.ECIAI1_0112,iECNA114_1301.ECNA114_0106,iECO103_1326.ECO103_0114,iECO111_1330.ECO111_0115,iECO26_1355.ECO26_0116,iECSE_1348.ECSE_0114,iECSF_1327.ECSF_0127,iECSP_1301.ECSP_0115,iECUMN_1333.ECUMN_0111,iECW_1372.ECW_m0111,iECs_1301.ECs0118,iEKO11_1354.EKO11_3802,iETEC_1333.ETEC_0110,iEcDH1_1363.EcDH1_3488,iEcE24377_1341.EcE24377A_0116,iEcHS_1320.EcHS_A0118,iEcSMS35_1347.EcSMS35_0124,iEcolC_1368.EcolC_3545,iG2583_1286.G2583_0118,iJN746.PP_0339,iJO1366.b0114,iJR904.b0114,iUMNK88_1353.UMNK88_112,iWFL_1372.ECW_m0111,iY75_1357.Y75_RS00580,iZ_1308.Z0124	Bacteria	1MV21@1224,1RN6K@1236,3XP9X@561,COG2609@1,COG2609@2	NA|NA|NA	F	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C1_03118	155864.EDL933_0114	5.4e-133	480.3	Escherichia	pdhR	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141		ko:K05799					ko00000,ko03000				Bacteria	1MUP9@1224,1RNPJ@1236,3XPBN@561,COG2186@1,COG2186@2	NA|NA|NA	K	Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd
C1_03119	316407.85674334	2.3e-251	874.4	Escherichia	aroP	GO:0003333,GO:0003674,GO:0005215,GO:0005302,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008104,GO:0008150,GO:0008320,GO:0008324,GO:0008509,GO:0008514,GO:0008565,GO:0009977,GO:0015031,GO:0015075,GO:0015171,GO:0015173,GO:0015179,GO:0015192,GO:0015196,GO:0015238,GO:0015291,GO:0015318,GO:0015399,GO:0015405,GO:0015450,GO:0015711,GO:0015801,GO:0015807,GO:0015823,GO:0015827,GO:0015828,GO:0015833,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0033036,GO:0034220,GO:0042221,GO:0042493,GO:0042886,GO:0042887,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903825,GO:1904680,GO:1905039		ko:K03293,ko:K11732,ko:K11734					ko00000,ko02000	2.A.3.1,2.A.3.1.1,2.A.3.1.3		iAPECO1_1312.APECO1_1472,iECW_1372.ECW_m0628,iEcE24377_1341.EcE24377A_0114,iEcolC_1368.EcolC_3070,iUTI89_1310.UTI89_C0576,iWFL_1372.ECW_m0628	Bacteria	1MUPS@1224,1RNK0@1236,3XM6P@561,COG1113@1,COG1113@2	NA|NA|NA	U	Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan)
C1_03120	198214.SF0108	1.6e-157	562.0	Gammaproteobacteria	ampE	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	6.3.1.10	ko:K02227,ko:K03807	ko00860,ko01100,map00860,map01100	M00122	R06529,R07302	RC00090,RC00096	ko00000,ko00001,ko00002,ko01000				Bacteria	1MVMK@1224,1RQTI@1236,COG3725@1,COG3725@2	NA|NA|NA	V	regulatory protein AmpE
C1_03121	316407.21238958	8.2e-107	392.9	Escherichia	ampD	GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008745,GO:0009056,GO:0009057,GO:0009253,GO:0009254,GO:0009392,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0019867,GO:0030203,GO:0043167,GO:0043169,GO:0043170,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0061783,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575	3.5.1.28	ko:K03806,ko:K11066					ko00000,ko01000,ko01011			iAF1260.b0110,iB21_1397.B21_00108,iBWG_1329.BWG_0103,iEC55989_1330.EC55989_0103,iECBD_1354.ECBD_3509,iECB_1328.ECB_00109,iECDH10B_1368.ECDH10B_0090,iECDH1ME8569_1439.ECDH1ME8569_0104,iECD_1391.ECD_00109,iECIAI1_1343.ECIAI1_0107,iECO103_1326.ECO103_0110,iECO111_1330.ECO111_0111,iECO26_1355.ECO26_0112,iECSE_1348.ECSE_0110,iECW_1372.ECW_m0107,iEKO11_1354.EKO11_3806,iETEC_1333.ETEC_0106,iEcDH1_1363.EcDH1_3492,iEcE24377_1341.EcE24377A_0112,iEcHS_1320.EcHS_A0114,iEcolC_1368.EcolC_3549,iJO1366.b0110,iSFV_1184.SFV_0101,iSF_1195.SF0107,iSFxv_1172.SFxv_0113,iS_1188.S0109,iUMNK88_1353.UMNK88_108,iWFL_1372.ECW_m0107,iY75_1357.Y75_RS00560	Bacteria	1RDHU@1224,1S3PG@1236,3XN89@561,COG3023@1,COG3023@2	NA|NA|NA	V	Involved in both cell wall peptidoglycans recycling and beta-lactamase induction. Specifically cleaves the amide bond between the lactyl group of N-acetylmuramic acid and the alpha- amino group of the L-alanine in degradation products containing an anhydro N-acetylmuramyl moiety (By similarity)
C1_03122	316407.85674333	3.1e-164	584.3	Escherichia	nadC	GO:0003674,GO:0003824,GO:0004514,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016054,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034213,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0042737,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0072526,GO:0090407,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000			iECP_1309.ECP_0109	Bacteria	1MW0C@1224,1RMBU@1236,3XPB2@561,COG0157@1,COG0157@2	NA|NA|NA	F	Belongs to the NadC ModD family
C1_03123	316407.85674332	3.5e-76	290.8	Escherichia	ppdD	GO:0005575,GO:0005623,GO:0009289,GO:0042995,GO:0044464		ko:K02650,ko:K02682	ko02020,map02020				ko00000,ko00001,ko02035,ko02044	3.A.15.2			Bacteria	1N7EQ@1224,1SCES@1236,3XPNR@561,COG4969@1,COG4969@2	NA|NA|NA	NU	Prokaryotic N-terminal methylation motif
C1_03124	316407.85674331	4.7e-260	903.3	Escherichia	hofB			ko:K02454,ko:K02504,ko:K02652	ko03070,ko05111,map03070,map05111	M00331			ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2			Bacteria	1MU7V@1224,1RMBS@1236,3XMC0@561,COG2804@1,COG2804@2	NA|NA|NA	NU	ATP binding
C1_03125	316407.85674330	1.4e-220	771.9	Escherichia	hofC	GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0016020,GO:0032940,GO:0033036,GO:0042886,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098776		ko:K02455,ko:K02505,ko:K02653	ko03070,ko05111,map03070,map05111	M00331			ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2			Bacteria	1MV4U@1224,1RNV0@1236,3XMGZ@561,COG1459@1,COG1459@2	NA|NA|NA	U	protein transport across the cell outer membrane
C1_03126	199310.c0124	1.1e-195	689.1	Escherichia	guaC	GO:0003674,GO:0003824,GO:0003920,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0015949,GO:0015950,GO:0015951,GO:0016020,GO:0016491,GO:0016651,GO:0016657,GO:0019637,GO:0019693,GO:0034641,GO:0042802,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.1.1.205,1.7.1.7	ko:K00088,ko:K00364	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R01134,R08240	RC00143,RC00457,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147			iEC042_1314.EC042_0103,iECIAI39_1322.ECIAI39_0105,iECUMN_1333.ECUMN_0102	Bacteria	1MUJM@1224,1RPZY@1236,3XNMG@561,COG0516@1,COG0516@2	NA|NA|NA	F	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
C1_03127	155864.EDL933_0105	4.9e-108	397.1	Escherichia	coaE	GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000			iECP_1309.ECP_0104	Bacteria	1RCXT@1224,1S3NR@1236,3XMTW@561,COG0237@1,COG0237@2	NA|NA|NA	F	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C1_03128	316407.85674327	1.9e-138	498.4	Escherichia	zapD	GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0007049,GO:0008150,GO:0009987,GO:0019954,GO:0022402,GO:0022414,GO:0032153,GO:0032505,GO:0042802,GO:0043093,GO:0044424,GO:0044444,GO:0044464,GO:0051301		ko:K18778					ko00000,ko03036				Bacteria	1MW69@1224,1RNPD@1236,3XMAW@561,COG4582@1,COG4582@2	NA|NA|NA	D	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
C1_03129	155864.EDL933_0103	1.2e-31	141.7	Escherichia	yacG	GO:0003674,GO:0004857,GO:0005488,GO:0008150,GO:0008270,GO:0008657,GO:0010911,GO:0030234,GO:0032780,GO:0042030,GO:0043086,GO:0043167,GO:0043169,GO:0043462,GO:0044092,GO:0046872,GO:0046914,GO:0050790,GO:0051336,GO:0051346,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0072586,GO:0098772,GO:2000371,GO:2000372	2.7.1.24	ko:K00859,ko:K09862	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000				Bacteria	1NGJ8@1224,1SC7M@1236,3XPZW@561,COG3024@1,COG3024@2	NA|NA|NA	S	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C1_03130	199310.c0117	1.1e-70	272.3	Escherichia	mutT	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008413,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017110,GO:0030145,GO:0033554,GO:0034641,GO:0035539,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044715,GO:0044716,GO:0046483,GO:0046872,GO:0046914,GO:0047429,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	3.6.1.55,3.6.1.65	ko:K03574,ko:K08320					ko00000,ko01000,ko03400			iE2348C_1286.E2348C_0104,iE2348C_1286.E2348C_1887,iSDY_1059.SDY_0129	Bacteria	1RCZM@1224,1RS3S@1236,3XPPA@561,COG0494@1,COG0494@2	NA|NA|NA	L	Belongs to the Nudix hydrolase family
C1_03131	316407.85674325	0.0	1731.1	Escherichia	secA	GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006457,GO:0006605,GO:0006810,GO:0006886,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015627,GO:0015628,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0034613,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042802,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061077,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:0098776,GO:1901265,GO:1901363,GO:1904680		ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4			Bacteria	1MUJZ@1224,1RM9M@1236,3XN2C@561,COG0653@1,COG0653@2	NA|NA|NA	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
C1_03132	155864.EDL933_0100	7.2e-109	399.8	Escherichia	secM	GO:0003674,GO:0005575,GO:0005623,GO:0006417,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0010608,GO:0019222,GO:0031323,GO:0031326,GO:0032268,GO:0034248,GO:0042597,GO:0044464,GO:0045182,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0080090,GO:2000112		ko:K13301	ko03060,ko03070,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044				Bacteria	1RC3K@1224,1S7VM@1236,2ATX7@1,31JGK@2,3XPHV@561	NA|NA|NA	U	Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation
C1_03133	155864.EDL933_0099	1e-173	615.9	Escherichia	lpxC	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0008654,GO:0008759,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	3.5.1.108,4.2.1.59	ko:K02535,ko:K16363	ko00061,ko00540,ko01100,ko01212,map00061,map00540,map01100,map01212	M00060,M00083	R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965	RC00166,RC00300,RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004,ko01005			iECS88_1305.ECS88_0100	Bacteria	1MV6T@1224,1RQ72@1236,3XP96@561,COG0774@1,COG0774@2	NA|NA|NA	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis
C1_03134	155864.EDL933_0098	1.7e-207	728.4	Escherichia	ftsZ	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022607,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0051258,GO:0051301,GO:0065003,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K03531	ko04112,map04112				ko00000,ko00001,ko02048,ko03036,ko04812				Bacteria	1MV2X@1224,1RPZS@1236,3XPCM@561,COG0206@1,COG0206@2	NA|NA|NA	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C1_03135	155864.EDL933_0097	1.9e-236	824.7	Escherichia	ftsA	GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0017076,GO:0030554,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363		ko:K03590	ko04112,map04112				ko00000,ko00001,ko03036,ko04812				Bacteria	1MUSR@1224,1RMXY@1236,3XNPQ@561,COG0849@1,COG0849@2	NA|NA|NA	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
C1_03136	155864.EDL933_0096	1.8e-153	548.5	Escherichia	ftsQ	GO:0000003,GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0019954,GO:0022402,GO:0022414,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032505,GO:0032506,GO:0042802,GO:0043093,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047	6.3.2.4	ko:K01921,ko:K03589	ko00473,ko00550,ko01100,ko01502,ko04112,map00473,map00550,map01100,map01502,map04112		R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011,ko03036				Bacteria	1N0T7@1224,1S9FJ@1236,3XPDZ@561,COG1589@1,COG1589@2	NA|NA|NA	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C1_03137	316407.21321973	7.4e-169	599.7	Escherichia	ddl	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008716,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	1.3.1.98,6.3.2.4	ko:K00075,ko:K01921	ko00473,ko00520,ko00550,ko01100,ko01502,map00473,map00520,map00550,map01100,map01502		R01150,R03191,R03192	RC00064,RC00141,RC02639	ko00000,ko00001,ko01000,ko01011			iAF1260.b0381,iB21_1397.B21_00332,iBWG_1329.BWG_0265,iE2348C_1286.E2348C_0317,iEC042_1314.EC042_0413,iEC55989_1330.EC55989_0386,iECBD_1354.ECBD_3283,iECB_1328.ECB_00328,iECDH10B_1368.ECDH10B_0338,iECDH1ME8569_1439.ECDH1ME8569_0367,iECD_1391.ECD_00328,iECH74115_1262.ECH74115_0453,iECIAI1_1343.ECIAI1_0377,iECIAI39_1322.ECIAI39_0301,iECO103_1326.ECO103_0356,iECO111_1330.ECO111_0411,iECO26_1355.ECO26_0095,iECO26_1355.ECO26_0414,iECSE_1348.ECSE_0401,iECSP_1301.ECSP_0441,iECs_1301.ECs0431,iETEC_1333.ETEC_0434,iEcDH1_1363.EcDH1_3227,iEcE24377_1341.EcE24377A_0406,iEcHS_1320.EcHS_A0447,iEcSMS35_1347.EcSMS35_0410,iEcolC_1368.EcolC_3251,iJO1366.b0381,iJR904.b0381,iSF_1195.SF0232,iSFxv_1172.SFxv_0245,iS_1188.S0254,iUMNK88_1353.UMNK88_429,iY75_1357.Y75_RS01965,iZ_1308.Z0477	Bacteria	1MUTB@1224,1RMTM@1236,3XMQE@561,COG1181@1,COG1181@2	NA|NA|NA	F	Belongs to the D-alanine--D-alanine ligase family
C1_03138	155864.EDL933_0094	2.3e-281	974.2	Escherichia	murC	GO:0000166,GO:0000270,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034645,GO:0035639,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.2.45,6.3.2.8	ko:K01924,ko:K02558	ko00471,ko00550,ko01100,map00471,map00550,map01100		R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011			iECP_1309.ECP_0093,iJN678.murC,iSDY_1059.SDY_4251	Bacteria	1MV68@1224,1RN88@1236,3XP40@561,COG0773@1,COG0773@2	NA|NA|NA	M	Belongs to the MurCDEF family
C1_03139	316407.21321971	4.4e-197	693.7	Escherichia	murG	GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0050511,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112		R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011		GT28	iLJ478.TM0232,iSFV_1184.SFV_0083,iSF_1195.SF0087,iSFxv_1172.SFxv_0091,iS_1188.S0089	Bacteria	1MVIB@1224,1RMQ3@1236,3XNRS@561,COG0707@1,COG0707@2	NA|NA|NA	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C1_03140	155864.EDL933_0092	8.9e-226	789.3	Escherichia	ftsW	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008360,GO:0009987,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032153,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051179,GO:0051234,GO:0051301,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:1901264,GO:1901505	2.4.1.227	ko:K02563,ko:K03588	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112		R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011,ko02000,ko03036	2.A.103.1	GT28		Bacteria	1MVDB@1224,1RMIV@1236,3XMYW@561,COG0772@1,COG0772@2	NA|NA|NA	D	Peptidoglycan polymerase that is essential for cell division
C1_03141	316407.21321969	1.4e-245	855.1	Escherichia	murD	GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008764,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100		R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011			iAPECO1_1312.APECO1_1898,iECNA114_1301.ECNA114_0081,iECOK1_1307.ECOK1_0089,iECP_1309.ECP_0090,iECS88_1305.ECS88_0091,iECSF_1327.ECSF_0098,iLF82_1304.LF82_1418,iNRG857_1313.NRG857_00450,iUMN146_1321.UM146_23225,iUTI89_1310.UTI89_C0097	Bacteria	1MVYD@1224,1RP25@1236,3XM3E@561,COG0771@1,COG0771@2	NA|NA|NA	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C1_03142	198214.SF0084	1.3e-201	708.8	Gammaproteobacteria	mraY	GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502		R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146		iAF987.Gmet_0409,iEC042_1314.EC042_0088,iECABU_c1320.ECABU_c00920,iECED1_1282.ECED1_0088,iECH74115_1262.ECH74115_0095,iECSP_1301.ECSP_0090,iECs_1301.ECs0091,iG2583_1286.G2583_0091,iSDY_1059.SDY_0117,iZ_1308.Z0097,ic_1306.c0105	Bacteria	1MUTK@1224,1RNIG@1236,COG0472@1,COG0472@2	NA|NA|NA	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C1_03143	469008.B21_00086	1e-246	859.0	Escherichia	murF	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008766,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0047480,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502		R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011			iB21_1397.B21_00086,iEC042_1314.EC042_0087,iEC55989_1330.EC55989_0082,iECBD_1354.ECBD_3531,iECB_1328.ECB_00087,iECD_1391.ECD_00087,iECIAI1_1343.ECIAI1_0085,iECO103_1326.ECO103_0088,iECO111_1330.ECO111_0089,iECO26_1355.ECO26_0089,iECSE_1348.ECSE_0088,iECW_1372.ECW_m0085,iEKO11_1354.EKO11_3828,iEcE24377_1341.EcE24377A_0088,iEcHS_1320.EcHS_A0092,iEcolC_1368.EcolC_3571,iSBO_1134.SBO_0074,iSSON_1240.SSON_0094,iSbBS512_1146.SbBS512_E0079,iUMNK88_1353.UMNK88_86,iWFL_1372.ECW_m0085,iYL1228.KPN_00090	Bacteria	1QTSF@1224,1RMGD@1236,3XMEK@561,COG0770@1,COG0770@2	NA|NA|NA	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
C1_03144	481805.EcolC_3572	7.8e-285	985.7	Escherichia	murE	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	3.4.16.4,6.3.2.10,6.3.2.13	ko:K01928,ko:K03587,ko:K15792	ko00300,ko00550,ko01501,map00300,map00550,map01501		R02788,R04617	RC00064,RC00090,RC00141	ko00000,ko00001,ko01000,ko01011,ko03036			iECO103_1326.ECO103_0087,iECO111_1330.ECO111_0088,iECW_1372.ECW_m0084,iEKO11_1354.EKO11_3829,iWFL_1372.ECW_m0084,ic_1306.c0103	Bacteria	1MU6P@1224,1RMD6@1236,3XNJS@561,COG0769@1,COG0769@2	NA|NA|NA	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C1_03145	155864.EDL933_0087	0.0	1156.7	Escherichia	ftsI	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008144,GO:0008150,GO:0008658,GO:0008955,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0031224,GO:0031226,GO:0031406,GO:0032153,GO:0033218,GO:0033293,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:1901363,GO:1901681	3.4.16.4	ko:K03587,ko:K08384,ko:K08724,ko:K12552,ko:K12556	ko00550,ko01100,ko01501,map00550,map01100,map01501				ko00000,ko00001,ko01000,ko01011,ko03036			iSSON_1240.SSON_0092	Bacteria	1MUNY@1224,1RNGW@1236,3XM4D@561,COG0768@1,COG0768@2	NA|NA|NA	M	of the peptidoglycan cell wall at the division septum
C1_03146	1440052.EAKF1_ch1338c	2.5e-59	234.6	Escherichia	ftsL	GO:0000003,GO:0000910,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0019954,GO:0022402,GO:0022414,GO:0031224,GO:0031226,GO:0032153,GO:0032505,GO:0043093,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0071944		ko:K03586					ko00000,ko03036				Bacteria	1N9MH@1224,1SC7P@1236,3XPMD@561,COG3116@1,COG3116@2	NA|NA|NA	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C1_03147	155864.EDL933_0085	9.6e-172	609.4	Escherichia	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438					ko00000,ko01000,ko03009				Bacteria	1MUT4@1224,1RM7M@1236,3XNTS@561,COG0275@1,COG0275@2	NA|NA|NA	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
C1_03148	155864.EDL933_0084	6.5e-81	306.6	Escherichia	mraZ	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141		ko:K03925					ko00000				Bacteria	1RHCG@1224,1S63F@1236,3XPDS@561,COG2001@1,COG2001@2	NA|NA|NA	K	Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster. Acts by binding directly to DNA. May also regulate the expression of genes outside the dcw cluster
C1_03149	155864.EDL933_0083	3.5e-188	664.1	Escherichia	fruR	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006355,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016052,GO:0016053,GO:0016310,GO:0017144,GO:0018130,GO:0019219,GO:0019222,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031326,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051186,GO:0051188,GO:0051252,GO:0055086,GO:0060255,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903506,GO:2000112,GO:2001141	3.2.1.26	ko:K01193,ko:K02529,ko:K03435	ko00052,ko00500,ko01100,map00052,map00500,map01100		R00801,R00802,R02410,R03635,R03921,R06088	RC00028,RC00077	ko00000,ko00001,ko01000,ko03000		GH32		Bacteria	1MXQ1@1224,1RNR1@1236,3XN1T@561,COG1609@1,COG1609@2	NA|NA|NA	K	Global transcriptional regulator, which plays an important role in the regulation of carbon metabolism
C1_03150	1440052.EAKF1_ch1343c	1.5e-80	305.4	Escherichia	ilvH	GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_1906,iECNA114_1301.ECNA114_0072,iEcSMS35_1347.EcSMS35_0084,iG2583_1286.G2583_0082,iSFxv_1172.SFxv_0077,iUTI89_1310.UTI89_C0086	Bacteria	1RAGN@1224,1S20I@1236,3XP6U@561,COG0440@1,COG0440@2	NA|NA|NA	E	acetolactate synthase
C1_03151	316407.85674319	0.0	1146.0	Escherichia	ilvI	GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030976,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_1907,iB21_1397.B21_00078,iBWG_1329.BWG_0073,iECBD_1354.ECBD_3539,iECB_1328.ECB_00079,iECD_1391.ECD_00079,iUTI89_1310.UTI89_C0085,iYL1228.KPN_00082	Bacteria	1MU6U@1224,1RMQQ@1236,3XNV1@561,COG0028@1,COG0028@2	NA|NA|NA	H	acetolactate synthase activity
C1_03152	316407.85674318	9.9e-177	625.9	Escherichia	leuO	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032991,GO:0032993,GO:0043565,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141		ko:K05798					ko00000,ko03000			iECW_1372.ECW_m0076,iWFL_1372.ECW_m0076	Bacteria	1MX24@1224,1RQP0@1236,3XM7V@561,COG0583@1,COG0583@2	NA|NA|NA	K	uxaCA, sdaCB and yjiY. H-NS repression of the bgl operon, leading to the ability to metabolize some beta-glucosides. It also directly activates the bgl operon. Activation is H-NS and BglJ-RcsB independent
C1_03153	316407.85674317	1.3e-293	1015.0	Escherichia	leuA	GO:0003674,GO:0003824,GO:0003852,GO:0003985,GO:0003988,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046912,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000			iSFV_1184.SFV_0066	Bacteria	1MUNQ@1224,1RMWE@1236,3XNCN@561,COG0119@1,COG0119@2	NA|NA|NA	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1_03154	316407.21321955	2.4e-206	724.5	Escherichia	leuB	GO:0000287,GO:0003674,GO:0003824,GO:0003862,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030145,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034198,GO:0042594,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0071496,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1990928	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000			iECs_1301.ECs0077,iYL1228.KPN_00079,iZ_1308.Z0082	Bacteria	1MUH4@1224,1RMZQ@1236,3XNII@561,COG0473@1,COG0473@2	NA|NA|NA	CE	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
C1_03155	199310.c0089	3.7e-268	930.2	Escherichia	leuC	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016853,GO:0016866,GO:0019752,GO:0030312,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000			iEcE24377_1341.EcE24377A_0075,iPC815.YPO0531,iSB619.SA_RS10700	Bacteria	1MVYR@1224,1RMF6@1236,3XN9T@561,COG0065@1,COG0065@2	NA|NA|NA	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C1_03156	316407.21321953	1.3e-113	415.6	Escherichia	leuD	GO:0003674,GO:0003824,GO:0003861,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009316,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000				Bacteria	1MVXB@1224,1RNMK@1236,3XN6D@561,COG0066@1,COG0066@2	NA|NA|NA	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C1_03157	316407.85674315	1.6e-208	731.9	Escherichia	setA	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006950,GO:0007059,GO:0008150,GO:0008643,GO:0009987,GO:0015766,GO:0015767,GO:0015772,GO:0016020,GO:0016021,GO:0031224,GO:0033554,GO:0036447,GO:0036448,GO:0044425,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0071702,GO:0071944		ko:K03291					ko00000,ko02000	2.A.1.20		iEC042_1314.EC042_2403,iECDH1ME8569_1439.ECDH1ME8569_0068	Bacteria	1MWWU@1224,1RN2I@1236,3XP9H@561,COG0477@1,COG2814@2	NA|NA|NA	P	Involved in the efflux of sugars. The physiological role may be the detoxification of non-metabolizable sugar analogs. Can transport IPTG, lactose and glucose. Has broad substrate specificity, with preferences for glucosides or galactosides with alkyl or aryl substituents
C1_03158	469008.B21_04251	1.1e-17	94.7	Escherichia	sgrT	GO:0003674,GO:0004857,GO:0008150,GO:0010827,GO:0010829,GO:0030234,GO:0032879,GO:0034762,GO:0034763,GO:0043086,GO:0044092,GO:0046324,GO:0046325,GO:0048519,GO:0050789,GO:0050790,GO:0051049,GO:0051051,GO:0065007,GO:0065009,GO:0098772											Bacteria	1QIS6@1224,1TGMJ@1236,2AV6G@1,31KWV@2,3XRB6@561	NA|NA|NA	C	Inhibitor of glucose uptake transporter SgrT
C1_03159	481805.EcolC_3588	0.0	1141.7	Escherichia	sgrR	GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005575,GO:0005623,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0030288,GO:0030313,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031975,GO:0042597,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K11925					ko00000,ko03000				Bacteria	1N2NK@1224,1RP2Z@1236,3XM3Y@561,COG4533@1,COG4533@2	NA|NA|NA	K	Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain
C1_03160	198214.SF0063	1.1e-186	659.1	Gammaproteobacteria	tbpA	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0008144,GO:0008150,GO:0015888,GO:0015893,GO:0019842,GO:0030288,GO:0030313,GO:0030975,GO:0030976,GO:0031975,GO:0036094,GO:0042221,GO:0042493,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0044464,GO:0045117,GO:0048037,GO:0050662,GO:0050896,GO:0051179,GO:0051180,GO:0051234,GO:0071702,GO:0071705,GO:0072348,GO:0097159,GO:1901363,GO:1901681		ko:K02064	ko02010,map02010	M00191			ko00000,ko00001,ko00002,ko02000	3.A.1.19		iAPECO1_1312.APECO1_1914,iSFxv_1172.SFxv_0065,iUTI89_1310.UTI89_C0076	Bacteria	1MUBB@1224,1RMQ9@1236,COG4143@1,COG4143@2	NA|NA|NA	P	thiamine ABC transporter
C1_03161	198214.SF0062	4.2e-300	1036.6	Gammaproteobacteria	thiP	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015234,GO:0015238,GO:0015893,GO:0016020,GO:0022857,GO:0035461,GO:0042221,GO:0042493,GO:0044464,GO:0045117,GO:0050896,GO:0051179,GO:0051180,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071934,GO:0071944,GO:0072348,GO:0072531,GO:0090482,GO:1901474,GO:1901682		ko:K02063	ko02010,map02010	M00191			ko00000,ko00001,ko00002,ko02000	3.A.1.19		iAPECO1_1312.APECO1_1915,iECIAI1_1343.ECIAI1_0067,iECO103_1326.ECO103_0068,iECO111_1330.ECO111_0069,iECO26_1355.ECO26_0069,iECOK1_1307.ECOK1_0068,iECS88_1305.ECS88_0072,iECSE_1348.ECSE_0067,iECUMN_1333.ECUMN_0068,iPC815.YPO0521,iSF_1195.SF0062,iSFxv_1172.SFxv_0064,iS_1188.S0064,iUMN146_1321.UM146_23130,iUTI89_1310.UTI89_C0075	Bacteria	1MWCF@1224,1RNHK@1236,COG1178@1,COG1178@2	NA|NA|NA	P	with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell
C1_03162	481805.EcolC_3591	1.3e-120	439.1	Escherichia	thiQ	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0006810,GO:0006855,GO:0008144,GO:0008150,GO:0015234,GO:0015238,GO:0015399,GO:0015405,GO:0015888,GO:0015893,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035461,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043492,GO:0045117,GO:0050896,GO:0051179,GO:0051180,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071934,GO:0072348,GO:0072531,GO:0090482,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901474,GO:1901682		ko:K02062	ko02010,map02010	M00191			ko00000,ko00001,ko00002,ko02000	3.A.1.19		iAF1260.b0066,iEC55989_1330.EC55989_0064,iECABU_c1320.ECABU_c00740,iECDH1ME8569_1439.ECDH1ME8569_0065,iECO103_1326.ECO103_0067,iECO111_1330.ECO111_0068,iECO26_1355.ECO26_0068,iECSE_1348.ECSE_0066,iETEC_1333.ETEC_0065,iEcDH1_1363.EcDH1_3533,iJO1366.b0066,iJR904.b0066,iUMNK88_1353.UMNK88_64,iY75_1357.Y75_RS00335,ic_1306.c0082	Bacteria	1MV78@1224,1RQH3@1236,3XNBK@561,COG3840@1,COG3840@2	NA|NA|NA	P	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C1_03163	198214.SF0060	4.2e-141	507.3	Gammaproteobacteria	yabI	GO:0000003,GO:0000910,GO:0005575,GO:0005623,GO:0005886,GO:0007049,GO:0008150,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0032505,GO:0043093,GO:0044464,GO:0050896,GO:0051301,GO:0071944	3.6.1.27	ko:K03975,ko:K19302	ko00550,map00550		R05627	RC00002	ko00000,ko00001,ko01000,ko01011				Bacteria	1R0F3@1224,1RPDS@1236,COG0586@1,COG0586@2	NA|NA|NA	I	membrane-associated protein
C1_03164	155864.EDL933_0066	1.4e-172	612.1	Escherichia	araC	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006355,GO:0008150,GO:0008152,GO:0009056,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016052,GO:0019219,GO:0019222,GO:0019321,GO:0019323,GO:0019566,GO:0019568,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0042802,GO:0043565,GO:0044212,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046365,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1901575,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K02099,ko:K07720	ko02020,map02020	M00519			ko00000,ko00001,ko00002,ko02022,ko03000				Bacteria	1MVS8@1224,1RQ3Y@1236,3XPF8@561,COG4977@1,COG4977@2	NA|NA|NA	K	This protein controls the expression of at least six genes that are involved in the transport and catabolism of L- arabinose. It regulates initiation of transcription of the araBAD operon and it also controls its own synthesis. The L-arabinose operon displays both positive and negative regulation through AraC
C1_03165	198214.SF0058	0.0	1140.6	Gammaproteobacteria	araB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005996,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008741,GO:0009056,GO:0009058,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019321,GO:0019323,GO:0019566,GO:0019568,GO:0019569,GO:0019572,GO:0019637,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046365,GO:0046373,GO:0046835,GO:0051167,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901159,GO:1901575,GO:1901576	2.7.1.16	ko:K00853	ko00040,ko01100,map00040,map01100		R01526,R02439	RC00002,RC00538	ko00000,ko00001,ko01000			iBWG_1329.BWG_0059,iECH74115_1262.ECH74115_0068,iECSP_1301.ECSP_0067,iECs_1301.ECs0067,iG2583_1286.G2583_0066,iPC815.YPO2254,iZ_1308.Z0072	Bacteria	1MY11@1224,1RP3F@1236,COG1069@1,COG1069@2	NA|NA|NA	C	Belongs to the ribulokinase family
C1_03166	362663.ECP_0063	1.2e-301	1041.6	Escherichia	araA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008733,GO:0009056,GO:0009058,GO:0009987,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0019566,GO:0019568,GO:0019569,GO:0019572,GO:0019637,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046373,GO:0051167,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901159,GO:1901575,GO:1901576	5.3.1.4	ko:K01804	ko00040,ko01100,map00040,map01100		R01761	RC00516	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_1922,iB21_1397.B21_00063,iBWG_1329.BWG_0058,iE2348C_1286.E2348C_0063,iECBD_1354.ECBD_3555,iECD_1391.ECD_00064,iECED1_1282.ECED1_0061,iECIAI1_1343.ECIAI1_0062,iECNA114_1301.ECNA114_0050,iECO103_1326.ECO103_0063,iECO26_1355.ECO26_0064,iECOK1_1307.ECOK1_0061,iECP_1309.ECP_0063,iECS88_1305.ECS88_0065,iECSE_1348.ECSE_0062,iECW_1372.ECW_m0060,iEKO11_1354.EKO11_3852,iEcE24377_1341.EcE24377A_0064,iEcHS_1320.EcHS_A0066,iEcSMS35_1347.EcSMS35_0064,iEcolC_1368.EcolC_3595,iLF82_1304.LF82_0105,iLJ478.TM0276,iNRG857_1313.NRG857_00320,iSBO_1134.SBO_0049,iSSON_1240.SSON_0068,iUMN146_1321.UM146_23095,iUTI89_1310.UTI89_C0067,iWFL_1372.ECW_m0060	Bacteria	1MW0J@1224,1RQEF@1236,3XN18@561,COG2160@1,COG2160@2	NA|NA|NA	G	Catalyzes the conversion of L-arabinose to L-ribulose
C1_03167	316407.21321943	3.6e-131	474.2	Escherichia	araD	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006004,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008738,GO:0008742,GO:0008994,GO:0009056,GO:0009058,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0016853,GO:0016854,GO:0016857,GO:0019299,GO:0019301,GO:0019317,GO:0019318,GO:0019320,GO:0019321,GO:0019323,GO:0019324,GO:0019566,GO:0019568,GO:0019569,GO:0019571,GO:0019572,GO:0019637,GO:0019752,GO:0019852,GO:0042354,GO:0042355,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046372,GO:0046373,GO:0046872,GO:0046914,GO:0051167,GO:0051186,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901159,GO:1901575,GO:1901576	4.1.1.104,4.1.2.17,4.1.2.19,5.1.3.4	ko:K01628,ko:K01629,ko:K03077,ko:K22130	ko00040,ko00051,ko00053,ko01100,ko01120,map00040,map00051,map00053,map01100,map01120	M00550	R01785,R02262,R02263,R05850	RC00438,RC00599,RC00603,RC00604,RC01479	ko00000,ko00001,ko00002,ko01000			iECED1_1282.ECED1_3191,iECO111_1330.ECO111_4403,iLF82_1304.LF82_1866,iNRG857_1313.NRG857_19475,iSDY_1059.SDY_4367,iSSON_1240.SSON_0067	Bacteria	1MU54@1224,1RMIP@1236,3XMI6@561,COG0235@1,COG0235@2	NA|NA|NA	G	Belongs to the aldolase class II family. AraD FucA subfamily
C1_03168	316407.85674307	0.0	1622.8	Escherichia	polB	GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0018130,GO:0019438,GO:0031668,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045004,GO:0045005,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02336					ko00000,ko01000,ko03400				Bacteria	1MVY9@1224,1RMQ1@1236,3XPER@561,COG0417@1,COG0417@2	NA|NA|NA	L	DNA polymerase
C1_03169	155864.EDL933_0061	0.0	1906.0	Escherichia	rapA	GO:0000166,GO:0001000,GO:0003674,GO:0003676,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0030554,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043175,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141		ko:K03580					ko00000,ko01000,ko03021				Bacteria	1MX6H@1224,1RNRZ@1236,3XNHH@561,COG0553@1,COG0553@2	NA|NA|NA	K	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C1_03170	316407.85674306	6.1e-125	453.4	Escherichia	rluA	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.28,5.4.99.29	ko:K06177					ko00000,ko01000,ko03009,ko03016				Bacteria	1MVJ5@1224,1RN4N@1236,3XNBC@561,COG0564@1,COG0564@2	NA|NA|NA	J	Responsible for synthesis of pseudouridine from uracil
C1_03171	155864.EDL933_0058	2.6e-149	534.6	Escherichia	djlA	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0051087,GO:0071944		ko:K05801					ko00000,ko03110				Bacteria	1N270@1224,1RP0P@1236,3XMH7@561,COG1076@1,COG1076@2	NA|NA|NA	O	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host
C1_03172	316407.21321935	0.0	1627.8	Escherichia	lptD	GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0006869,GO:0008150,GO:0008509,GO:0008514,GO:0008643,GO:0009279,GO:0009636,GO:0009987,GO:0010876,GO:0015075,GO:0015136,GO:0015144,GO:0015157,GO:0015267,GO:0015288,GO:0015318,GO:0015478,GO:0015711,GO:0015739,GO:0015772,GO:0015849,GO:0015920,GO:0016020,GO:0016021,GO:0016043,GO:0019867,GO:0022607,GO:0022803,GO:0022829,GO:0022857,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031975,GO:0033036,GO:0034219,GO:0034220,GO:0042221,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045203,GO:0045229,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0061024,GO:0071702,GO:0071709,GO:0071840,GO:0071944,GO:0098656,GO:1901264,GO:1901505,GO:1903825,GO:1905039		ko:K04744,ko:K22110					ko00000,ko02000	1.B.35.1,1.B.35.2,1.B.42.1		iG2583_1286.G2583_0058,ic_1306.c5389	Bacteria	1MUJC@1224,1RQEX@1236,3XN2D@561,COG1452@1,COG1452@2	NA|NA|NA	M	Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C1_03173	155864.EDL933_0056	1.3e-235	822.0	Escherichia	surA	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006457,GO:0006458,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0022607,GO:0030288,GO:0030313,GO:0031647,GO:0031975,GO:0033218,GO:0036211,GO:0042277,GO:0042597,GO:0043163,GO:0043165,GO:0043170,GO:0043412,GO:0044085,GO:0044091,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0044764,GO:0045229,GO:0050821,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0060274,GO:0061024,GO:0061077,GO:0065007,GO:0065008,GO:0071704,GO:0071709,GO:0071840,GO:0140096,GO:1901564	5.2.1.8	ko:K03769,ko:K03771					ko00000,ko01000,ko03110				Bacteria	1MVB3@1224,1RMWU@1236,3XP9E@561,COG0760@1,COG0760@2	NA|NA|NA	O	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1_03174	155864.EDL933_0055	6.1e-185	653.3	Escherichia	pdxA	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008614,GO:0008615,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0036094,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046184,GO:0046483,GO:0046872,GO:0046914,GO:0048037,GO:0050570,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	1.1.1.262,1.1.1.408,1.1.1.409	ko:K00097,ko:K22024	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000			iECO111_1330.ECO111_0056	Bacteria	1MX5W@1224,1RNZV@1236,3XMAU@561,COG1995@1,COG1995@2	NA|NA|NA	H	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C1_03175	316407.85674303	1.6e-151	542.0	Escherichia	ksgA	GO:0000028,GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003723,GO:0003729,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0031167,GO:0032259,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043412,GO:0043414,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070475,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140102,GO:1901360,GO:1901363	2.1.1.182	ko:K02528			R10716	RC00003,RC03257	ko00000,ko01000,ko03009				Bacteria	1MVNU@1224,1RMHW@1236,3XMDQ@561,COG0030@1,COG0030@2	NA|NA|NA	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
C1_03176	155864.EDL933_0053	6.3e-66	256.5	Escherichia	apaG			ko:K06195					ko00000				Bacteria	1MZ2Z@1224,1S8SE@1236,3XPM5@561,COG2967@1,COG2967@2	NA|NA|NA	P	ApaG domain
C1_03177	316407.85674302	3.2e-166	590.9	Escherichia	apaH	GO:0003674,GO:0003824,GO:0004551,GO:0004721,GO:0006139,GO:0006464,GO:0006470,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008138,GO:0008150,GO:0008152,GO:0008796,GO:0008803,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0015949,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0019538,GO:0034641,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0140096,GO:1901360,GO:1901564	3.6.1.41	ko:K01525	ko00230,map00230		R00125	RC00002	ko00000,ko00001,ko01000			iECIAI39_1322.ECIAI39_0052,iEcSMS35_1347.EcSMS35_0053,iSDY_1059.SDY_0074	Bacteria	1MV10@1224,1RPUJ@1236,3XMZF@561,COG0639@1,COG0639@2	NA|NA|NA	T	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C1_03178	199310.c0058	3.1e-112	411.0	Escherichia	folA	GO:0000166,GO:0003674,GO:0003824,GO:0004146,GO:0005488,GO:0005542,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008144,GO:0008150,GO:0008152,GO:0016491,GO:0016645,GO:0016646,GO:0019842,GO:0031406,GO:0033218,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050661,GO:0050662,GO:0050896,GO:0051870,GO:0051871,GO:0055114,GO:0070401,GO:0070402,GO:0072341,GO:0097159,GO:1901265,GO:1901363	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000			iECBD_1354.ECBD_3567,iECDH1ME8569_1439.ECDH1ME8569_0047,iECNA114_1301.ECNA114_0036,iEcDH1_1363.EcDH1_3551,iEcSMS35_1347.EcSMS35_0050,iG2583_1286.G2583_0050,iNRG857_1313.NRG857_00250,iUMN146_1321.UM146_23020	Bacteria	1RH0P@1224,1S5VH@1236,3XPHN@561,COG0262@1,COG0262@2	NA|NA|NA	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C1_03179	469008.B21_00050	0.0	1157.5	Escherichia	kefC	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006885,GO:0008150,GO:0008324,GO:0009636,GO:0009987,GO:0010033,GO:0015075,GO:0015077,GO:0015079,GO:0015291,GO:0015318,GO:0015503,GO:0015643,GO:0015672,GO:0016020,GO:0016021,GO:0019899,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042592,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051234,GO:0051595,GO:0055067,GO:0055080,GO:0055085,GO:0065007,GO:0065008,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:1901654,GO:1901700		ko:K03455,ko:K11745,ko:K11747					ko00000,ko02000	2.A.37,2.A.37.1.1,2.A.37.1.2		iB21_1397.B21_03153,iEC55989_1330.EC55989_3754,iECBD_1354.ECBD_0398,iECB_1328.ECB_03201,iECD_1391.ECD_03201,iECO26_1355.ECO26_4439,iECOK1_1307.ECOK1_0046,iECS88_1305.ECS88_0050,iECSE_1348.ECSE_3612,iECW_1372.ECW_m3606,iEKO11_1354.EKO11_0394,iEcHS_1320.EcHS_A3547,iSSON_1240.SSON_3481,iUMN146_1321.UM146_23015,iUTI89_1310.UTI89_C0053,iWFL_1372.ECW_m3606	Bacteria	1MV34@1224,1RNVR@1236,3XN4I@561,COG0475@1,COG0475@2,COG1226@1,COG1226@2	NA|NA|NA	P	Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K( ) H( ) antiport
C1_03180	199310.c0056	1.1e-103	382.5	Escherichia	kefF	GO:0000166,GO:0003674,GO:0003824,GO:0003955,GO:0005488,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0010181,GO:0016491,GO:0016651,GO:0016655,GO:0022898,GO:0022900,GO:0032409,GO:0032411,GO:0032412,GO:0032414,GO:0032553,GO:0032879,GO:0034762,GO:0034764,GO:0034765,GO:0034767,GO:0036094,GO:0043167,GO:0043168,GO:0043269,GO:0043270,GO:0044093,GO:0044237,GO:0048037,GO:0048518,GO:0050662,GO:0050789,GO:0051049,GO:0051050,GO:0055114,GO:0065007,GO:0065009,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K03923,ko:K11746,ko:K11748					ko00000,ko02000	2.A.37.1.1,2.A.37.1.2		iLF82_1304.LF82_1283	Bacteria	1MXFT@1224,1RPAQ@1236,3XP8D@561,COG2249@1,COG2249@2	NA|NA|NA	C	Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefC. Shows redox enzymatic activity, but this enzymatic activity is not required for activation of KefC
C1_03181	316407.85674300	5.9e-252	876.3	Escherichia	yaaU	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0016020,GO:0044464,GO:0050896,GO:0071944		ko:K08368					ko00000,ko02000	2.A.1			Bacteria	1QV3V@1224,1T27B@1236,3XN87@561,COG2271@1,COG2271@2	NA|NA|NA	P	response to oxidative stress
C1_03182	198214.SF0041	2.2e-50	204.5	Gammaproteobacteria	fixX			ko:K03855					ko00000				Bacteria	1RHTX@1224,1S6EF@1236,COG2440@1,COG2440@2	NA|NA|NA	C	Could be a 3Fe-4S cluster-containing protein
C1_03183	199310.c0053	6.2e-238	829.7	Escherichia	fixC	GO:0006575,GO:0006577,GO:0006807,GO:0008150,GO:0008152,GO:0009437,GO:0009987,GO:0034641,GO:0044237,GO:0071704,GO:0097164,GO:1901564		ko:K00313					ko00000,ko01000				Bacteria	1MVU6@1224,1RNY5@1236,3XMZ6@561,COG0644@1,COG0644@2	NA|NA|NA	C	Could be part of an electron transfer system required for anaerobic carnitine reduction
C1_03184	316407.85674297	4.3e-172	610.5	Escherichia	fixB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006575,GO:0006577,GO:0006579,GO:0006629,GO:0006631,GO:0006635,GO:0006807,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009062,GO:0009437,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0019395,GO:0019752,GO:0022900,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0034641,GO:0036094,GO:0042219,GO:0042413,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044270,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:0097164,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	1.3.8.1	ko:K00248,ko:K03522	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212		R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000,ko04147				Bacteria	1MUFI@1224,1RMK7@1236,3XM52@561,COG2025@1,COG2025@2	NA|NA|NA	C	Required for anaerobic carnitine reduction. May bring reductant to CaiA
C1_03185	155864.EDL933_0042	2.1e-132	478.4	Escherichia	fixA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006575,GO:0006577,GO:0006579,GO:0006807,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009437,GO:0009987,GO:0016491,GO:0022900,GO:0034641,GO:0042219,GO:0042413,GO:0044237,GO:0044248,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071704,GO:0097164,GO:1901564,GO:1901565,GO:1901575		ko:K03521					ko00000				Bacteria	1MVH6@1224,1RN6F@1236,3XQE3@561,COG2086@1,COG2086@2	NA|NA|NA	C	Required for anaerobic carnitine reduction. May bring reductant to CaiA
C1_03186	316407.85674295	1.9e-294	1017.7	Escherichia	caiT	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0008519,GO:0015075,GO:0015101,GO:0015226,GO:0015651,GO:0015695,GO:0015696,GO:0015697,GO:0015838,GO:0015879,GO:0016020,GO:0022857,GO:0034220,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0072349,GO:0072488,GO:0098655,GO:1902603		ko:K05245					ko00000,ko02000	2.A.15.2		iB21_1397.B21_00043,iECBD_1354.ECBD_3575,iECB_1328.ECB_00044,iECD_1391.ECD_00044,iSF_1195.SF0037,iSFxv_1172.SFxv_0038,iS_1188.S0039	Bacteria	1MV0K@1224,1RP3E@1236,3XNPU@561,COG1292@1,COG1292@2	NA|NA|NA	M	Catalyzes the exchange of L-carnitine for gamma- butyrobetaine and related betaines
C1_03187	155864.EDL933_0040	1.2e-221	775.4	Escherichia	caiA		1.3.8.13	ko:K08297					ko00000,ko01000				Bacteria	1MUDR@1224,1RMMJ@1236,3XPD4@561,COG1960@1,COG1960@2	NA|NA|NA	I	Catalyzes the reduction of crotonobetainyl-CoA to gamma- butyrobetainyl-CoA
C1_03188	316407.21321920	1.1e-241	842.0	Escherichia	caiB	GO:0003674,GO:0003824,GO:0006575,GO:0006577,GO:0006579,GO:0006807,GO:0008150,GO:0008152,GO:0008735,GO:0009056,GO:0009437,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0034641,GO:0042219,GO:0042413,GO:0044237,GO:0044248,GO:0044270,GO:0071704,GO:0097164,GO:1901564,GO:1901565,GO:1901575	2.8.3.21	ko:K08298			R10643,R10644	RC00014,RC00131	ko00000,ko01000			iEC55989_1330.EC55989_0038,iECIAI1_1343.ECIAI1_0040,iECO103_1326.ECO103_0040,iECO111_1330.ECO111_0039,iECO26_1355.ECO26_0039,iEcHS_1320.EcHS_A0042,iSF_1195.SF0035,iSFxv_1172.SFxv_0036,iS_1188.S0037	Bacteria	1MU2K@1224,1RNB5@1236,3XP57@561,COG1804@1,COG1804@2	NA|NA|NA	C	Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl- CoA and gamma-butyrobetaine. Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl- CoA or L-carnitinyl-CoA to crotonobetaine to generate crotonobetainyl-CoA
C1_03189	155864.EDL933_0038	3.7e-306	1056.6	Escherichia	caiC	GO:0003674,GO:0003824,GO:0016405,GO:0016874,GO:0016877,GO:0016879,GO:0016881,GO:0051108,GO:0051109	6.2.1.48	ko:K02182					ko00000,ko01000			iECSE_1348.ECSE_0038,iNRG857_1313.NRG857_00195	Bacteria	1MU6G@1224,1RMQ4@1236,3XMZB@561,COG0318@1,COG0318@2	NA|NA|NA	IQ	Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle
C1_03190	316407.85674293	5.4e-144	516.9	Escherichia	caiD	GO:0003674,GO:0003824,GO:0004300,GO:0006082,GO:0006575,GO:0006577,GO:0006579,GO:0006629,GO:0006631,GO:0006635,GO:0006807,GO:0008150,GO:0008152,GO:0008809,GO:0009056,GO:0009062,GO:0009437,GO:0009987,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016856,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0034641,GO:0042219,GO:0042413,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044270,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:0097164,GO:1901564,GO:1901565,GO:1901575	4.2.1.149	ko:K08299			R10675	RC01095	ko00000,ko01000			iAPECO1_1312.APECO1_1945,iEC042_1314.EC042_0038,iECABU_c1320.ECABU_c00410,iECB_1328.ECB_00040,iECD_1391.ECD_00040,iECO103_1326.ECO103_0038,iECP_1309.ECP_0036,iETEC_1333.ETEC_0036,iNRG857_1313.NRG857_00190,iUMN146_1321.UM146_22960,ic_1306.c0045	Bacteria	1MWZC@1224,1RR3Z@1236,3XP09@561,COG1024@1,COG1024@2	NA|NA|NA	I	Catalyzes the reversible dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA
C1_03191	155864.EDL933_0036	5.9e-103	380.2	Escherichia	caiE	GO:0003674,GO:0003824,GO:0006575,GO:0006577,GO:0006807,GO:0008150,GO:0008152,GO:0008735,GO:0009437,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0034641,GO:0044237,GO:0071704,GO:0097164,GO:1901564		ko:K02617,ko:K08279					ko00000				Bacteria	1MVUI@1224,1RYPQ@1236,3XM7F@561,COG0663@1,COG0663@2	NA|NA|NA	S	Overproduction of CaiE stimulates the activity of CaiB and CaiD
C1_03192	155864.EDL933_0035	2.7e-67	261.2	Escherichia	caiF			ko:K08277					ko00000,ko03000				Bacteria	1RJ32@1224,1S6GM@1236,2BXKV@1,32FV2@2,3XRGK@561	NA|NA|NA	K	CaiF/GrlA transcriptional regulator
C1_03194	469008.B21_00036	0.0	2092.0	Escherichia	carB	GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000			iAF1260.b0033,iBWG_1329.BWG_0031,iECDH10B_1368.ECDH10B_0034,iECDH1ME8569_1439.ECDH1ME8569_0031,iECUMN_1333.ECUMN_0034,iEcDH1_1363.EcDH1_3566,iJO1366.b0033,iJR904.b0033,iPC815.YPO0482,iY75_1357.Y75_RS00170,iYL1228.KPN_00041	Bacteria	1MUDZ@1224,1RPIU@1236,3XMVN@561,COG0458@1,COG0458@2	NA|NA|NA	F	Carbamoyl-phosphate synthetase ammonia chain
C1_03195	155864.EDL933_0032	5.5e-222	776.5	Escherichia	carA	GO:0000050,GO:0003674,GO:0003824,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0032991,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_1950,iNJ661.Rv1383,iUTI89_1310.UTI89_C0036,ic_1306.c0040	Bacteria	1MUB9@1224,1RMAW@1236,3XMKS@561,COG0505@1,COG0505@2	NA|NA|NA	F	Carbamoyl-phosphate synthetase glutamine chain
C1_03196	469008.B21_00034	1.2e-146	525.8	Escherichia	dapB	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.17.1.8	ko:K00215,ko:K03546	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000,ko03400			iIT341.HP0510,iLJ478.TM1520,iSbBS512_1146.SbBS512_E0035	Bacteria	1MUCT@1224,1RMCZ@1236,3XMUX@561,COG0289@1,COG0289@2	NA|NA|NA	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
C1_03197	316407.21321912	5.1e-170	603.6	Escherichia	rihC	GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006152,GO:0006213,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008477,GO:0009056,GO:0009116,GO:0009119,GO:0009164,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019439,GO:0033554,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042454,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0045437,GO:0046131,GO:0046133,GO:0046135,GO:0046483,GO:0046700,GO:0046872,GO:0047405,GO:0047622,GO:0047724,GO:0050263,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658	3.2.2.1,3.2.2.8	ko:K01239,ko:K01250,ko:K10213,ko:K12700	ko00230,ko00240,ko00760,ko01100,map00230,map00240,map00760,map01100		R01245,R01273,R01677,R01770,R02137,R02143	RC00033,RC00063,RC00122,RC00318,RC00485	ko00000,ko00001,ko01000			iECH74115_1262.ECH74115_3298,iECNA114_1301.ECNA114_0014,iECSP_1301.ECSP_3040,iECs_1301.ECs3054,iEcE24377_1341.EcE24377A_0030,iLF82_1304.LF82_1885,iNRG857_1313.NRG857_00145,iSbBS512_1146.SbBS512_E0598,iYL1228.KPN_00025,iZ_1308.Z3419	Bacteria	1MUIW@1224,1RQ1V@1236,3XNKR@561,COG1957@1,COG1957@2	NA|NA|NA	F	Hydrolyzes both purine and pyrimidine ribonucleosides with a broad-substrate specificity
C1_03198	155864.EDL933_0028	1.6e-174	618.6	Escherichia	ispH	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0042380,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046490,GO:0048037,GO:0051536,GO:0051538,GO:0051540,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.17.7.4,2.7.4.25	ko:K00945,ko:K02945,ko:K03527	ko00240,ko00900,ko01100,ko01110,ko01130,ko03010,map00240,map00900,map01100,map01110,map01130,map03010	M00052,M00096,M00178	R00158,R00512,R01665,R05884,R08210	RC00002,RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko03011			iECIAI1_1343.ECIAI1_0030,iECW_1372.ECW_m0028,iEKO11_1354.EKO11_3884,iEcHS_1320.EcHS_A0031,iEcolC_1368.EcolC_3626,iIT341.HP0400,iLJ478.TM1444,iPC815.YPO0477,iSFV_1184.SFV_0023,iSF_1195.SF0026,iSFxv_1172.SFxv_0027,iS_1188.S0028,iWFL_1372.ECW_m0028,iYL1228.KPN_00024	Bacteria	1MU7G@1224,1RMN8@1236,3XM3C@561,COG0761@1,COG0761@2	NA|NA|NA	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C1_03199	155864.EDL933_0027	5e-78	297.0	Escherichia	fkpB	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0061077,GO:0071704,GO:0140096,GO:1901564	5.2.1.8	ko:K03774,ko:K03775					ko00000,ko01000,ko03110				Bacteria	1RHD1@1224,1S5YP@1236,3XPMW@561,COG1047@1,COG1047@2	NA|NA|NA	O	with 'Suc-Ala-Xaa-Pro-Phe-4-nitroanilide' where Xaa is the amino acid tested, was found to be Phe Leu Ile Lys Ala Trp His Gln
C1_03200	199310.c0031	3.4e-88	330.9	Escherichia	lspA	GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0042157,GO:0042158,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0097304,GO:0140096,GO:1901564,GO:1901566,GO:1901576	3.4.23.36	ko:K03101	ko03060,map03060				ko00000,ko00001,ko01000,ko01002				Bacteria	1RGV9@1224,1S60E@1236,3XP2H@561,COG0597@1,COG0597@2	NA|NA|NA	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C1_03201	316407.85674290	0.0	1922.5	Escherichia	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iG2583_1286.G2583_0027,iPC815.YPO0475	Bacteria	1MVBQ@1224,1RMTF@1236,3XNGC@561,COG0060@1,COG0060@2	NA|NA|NA	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C1_03202	198214.SF0021	3.8e-176	624.0	Gammaproteobacteria	ribF	GO:0003674,GO:0003824,GO:0003919,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008531,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016779,GO:0044237,GO:0070566	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000			iETEC_1333.ETEC_0025,iJN746.PP_0602	Bacteria	1MV9I@1224,1RN44@1236,COG0196@1,COG0196@2	NA|NA|NA	H	Belongs to the ribF family
C1_03203	1440052.EAKF1_ch1401	2.5e-37	161.0	Escherichia	rpsT	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030234,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0042979,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050790,GO:0065003,GO:0065007,GO:0065009,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02968	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1MZ94@1224,1S9AI@1236,3XPV1@561,COG0268@1,COG0268@2	NA|NA|NA	J	Binds directly to 16S ribosomal RNA
C1_03204	155864.EDL933_0022	6.3e-45	186.8	Bacteria	M1-336												Bacteria	COG1357@1,COG1357@2	NA|NA|NA	S	protein homooligomerization
C1_03205	155864.EDL933_0022	4.9e-82	310.8	Bacteria	M1-336												Bacteria	COG1357@1,COG1357@2	NA|NA|NA	S	protein homooligomerization
C1_03206	155864.EDL933_0019	5.8e-106	390.2	Escherichia	yehB			ko:K07347	ko05133,map05133				ko00000,ko00001,ko02000,ko02035,ko02044	1.B.11.3			Bacteria	1MUHE@1224,1RMPU@1236,3XN71@561,COG3188@1,COG3188@2	NA|NA|NA	NU	outer membrane usher protein
C1_03207	155864.EDL933_0019	2.3e-43	181.0	Escherichia	yehB			ko:K07347	ko05133,map05133				ko00000,ko00001,ko02000,ko02035,ko02044	1.B.11.3			Bacteria	1MUHE@1224,1RMPU@1236,3XN71@561,COG3188@1,COG3188@2	NA|NA|NA	NU	outer membrane usher protein
C1_03208	469008.B21_00021	2.4e-114	418.7	Gammaproteobacteria													Bacteria	1NEKI@1224,1SDNQ@1236,COG3539@1,COG3539@2	NA|NA|NA	NU	Fimbrial protein
C1_03209	469008.B21_00020	7.7e-171	606.3	Escherichia	nhaR	GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0003674,GO:0003700,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2000142,GO:2000144,GO:2001141		ko:K03717					ko00000,ko03000				Bacteria	1MVHT@1224,1RN7G@1236,3XPFK@561,COG0583@1,COG0583@2	NA|NA|NA	K	regulatory protein
C1_03210	155864.EDL933_0015	2.4e-209	734.6	Escherichia	nhaA	GO:0003674,GO:0005215,GO:0005451,GO:0005488,GO:0005543,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006873,GO:0006875,GO:0006883,GO:0006885,GO:0006950,GO:0006970,GO:0008150,GO:0008289,GO:0008324,GO:0009628,GO:0009651,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015491,GO:0015672,GO:0016020,GO:0016021,GO:0019725,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030004,GO:0030641,GO:0031224,GO:0031226,GO:0034220,GO:0035725,GO:0042592,GO:0043157,GO:0043167,GO:0043168,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051234,GO:0051453,GO:0055065,GO:0055067,GO:0055078,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099516,GO:1901611,GO:1901612,GO:1902600		ko:K03313					ko00000,ko02000	2.A.33.1		iSF_1195.SF0016,iSFxv_1172.SFxv_0017,iS_1188.S0018	Bacteria	1MW15@1224,1RNDE@1236,3XMTC@561,COG3004@1,COG3004@2	NA|NA|NA	P	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C1_03211	316407.21321904	7.6e-29	132.5	Gammaproteobacteria		GO:0008150,GO:0022611,GO:0032502		ko:K18919,ko:K18920,ko:K18921					ko00000,ko02048				Bacteria	1NHNZ@1224,1SGKV@1236,2EFY7@1,339QC@2	NA|NA|NA	S	PFAM Hok gef cell toxic protein
C1_03212	155864.EDL933_0014	5e-191	673.7	Escherichia	dnaJ	GO:0000988,GO:0000989,GO:0003674,GO:0003756,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006457,GO:0006458,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010556,GO:0015035,GO:0015036,GO:0016020,GO:0016032,GO:0016043,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0016989,GO:0019219,GO:0019222,GO:0022607,GO:0031323,GO:0031326,GO:0032991,GO:0034641,GO:0034645,GO:0042026,GO:0043167,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051704,GO:0055114,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0140096,GO:0140110,GO:1901360,GO:1901576,GO:1903506,GO:2001141		ko:K03686					ko00000,ko03029,ko03110				Bacteria	1MVMS@1224,1RNHY@1236,3XMY8@561,COG0484@1,COG0484@2	NA|NA|NA	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
C1_03213	1440052.EAKF1_ch1410c	0.0	1211.1	Escherichia	dnaK	GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0018995,GO:0019219,GO:0019222,GO:0020003,GO:0022607,GO:0030430,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0033643,GO:0033646,GO:0033655,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043230,GO:0043531,GO:0043656,GO:0043657,GO:0043933,GO:0044085,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0065010,GO:0070887,GO:0071310,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141		ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152				ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1			Bacteria	1MVEN@1224,1RMDD@1236,3XM30@561,COG0443@1,COG0443@2	NA|NA|NA	O	Heat shock 70 kDa protein
C1_03214	481805.EcolC_3643	6.2e-55	219.9	Escherichia	yaaI												Bacteria	1RDBB@1224,1S5G0@1236,29AC0@1,2ZXCI@2,3XPSU@561	NA|NA|NA	S	Protein of unknown function (DUF2541)
C1_03215	469008.B21_00011	8.7e-125	453.0	Escherichia	yaaW												Bacteria	1R4VH@1224,1S3Z6@1236,3XNA5@561,COG4735@1,COG4735@2	NA|NA|NA	S	Domain of unknown function (DUF3944)
C1_03216	155864.EDL933_0010	1.3e-99	369.0	Escherichia	yaaH	GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006835,GO:0006846,GO:0006855,GO:0008028,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015077,GO:0015078,GO:0015123,GO:0015238,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015355,GO:0015360,GO:0015672,GO:0015711,GO:0015718,GO:0015740,GO:0015744,GO:0015849,GO:0015893,GO:0016020,GO:0022804,GO:0022857,GO:0022890,GO:0034220,GO:0035433,GO:0042221,GO:0042493,GO:0042891,GO:0042895,GO:0043893,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071422,GO:0071702,GO:0071944,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:1902600,GO:1903825,GO:1905039		ko:K07034					ko00000				Bacteria	1N3HP@1224,1RMRK@1236,3XNU9@561,COG1584@1,COG1584@2	NA|NA|NA	S	Uptake of acetate and succinate. Transport is energetically dependent on the protonmotive force
C1_03217	469008.B21_00009	2.4e-104	384.8	Escherichia	mog	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0032324,GO:0034641,GO:0042278,GO:0042802,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061598,GO:0070566,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.7.7.75,2.8.1.12	ko:K03635,ko:K03638,ko:K03831	ko00790,ko01100,ko04122,map00790,map01100,map04122		R09395,R09726	RC00002,RC02507	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_1969,iECABU_c1320.ECABU_c00100,iECED1_1282.ECED1_0009,iECNA114_1301.ECNA114_4653,iECP_1309.ECP_0010,iECS88_1305.ECS88_0010,iECSF_1327.ECSF_0009,iECUMN_1333.ECUMN_0010,iEcSMS35_1347.EcSMS35_0008,iLF82_1304.LF82_1379,iNRG857_1313.NRG857_00050,iUMN146_1321.UM146_22820	Bacteria	1R9W2@1224,1RMZM@1236,3XMRI@561,COG0521@1,COG0521@2	NA|NA|NA	F	Catalyzes the adenylation of molybdopterin as part of the biosynthesis of the molybdenum-cofactor
C1_03218	198214.SF0009	9.4e-175	619.4	Gammaproteobacteria	tal	GO:0003674,GO:0003824,GO:0004801,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016740,GO:0016744,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564	2.2.1.2	ko:K00616,ko:K08313	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000			iECH74115_1262.ECH74115_5407,iECSP_1301.ECSP_5016,iECs_1301.ECs4875,iG2583_1286.G2583_4758,iSF_1195.SF0775,iSFxv_1172.SFxv_0845,iS_1188.S0818,iZ_1308.Z5501	Bacteria	1MWQ8@1224,1RMS0@1236,COG0176@1,COG0176@2	NA|NA|NA	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C1_03219	316407.21321898	1e-265	922.2	Escherichia	yaaJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03310					ko00000	2.A.25		iEcE24377_1341.EcE24377A_0007	Bacteria	1MUI3@1224,1RMNF@1236,3XN15@561,COG1115@1,COG1115@2	NA|NA|NA	E	alanine:sodium symporter activity
C1_03220	155864.EDL933_0006	3.5e-143	514.2	Escherichia	yaaA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0033194,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:1901700		ko:K09861					ko00000				Bacteria	1MUAF@1224,1RMTD@1236,3XMJK@561,COG3022@1,COG3022@2	NA|NA|NA	S	Belongs to the UPF0246 family
C1_03221	637910.ROD_00481	2.1e-161	575.1	Gammaproteobacteria	piv			ko:K07486					ko00000				Bacteria	1MXKJ@1224,1RSCP@1236,COG3547@1,COG3547@2	NA|NA|NA	L	Transposase
C1_03222	469008.B21_00005	3.7e-37	160.6	Escherichia	yaaX												Bacteria	1N42N@1224,1S9N3@1236,2B58A@1,32RQ3@2,3XQ1B@561	NA|NA|NA	S	Protein of unknown function (DUF2502)
C1_03223	155864.EDL933_0004	8e-246	855.9	Escherichia	thrC	GO:0003674,GO:0003824,GO:0004795,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000			iLF82_1304.LF82_2261,iNRG857_1313.NRG857_00025	Bacteria	1MUWQ@1224,1RQ0H@1236,3XP31@561,COG0498@1,COG0498@2	NA|NA|NA	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. To a lesser extent, is able to slowly catalyze the deamination of L-threonine into alpha-ketobutyrate and that of L- serine and 3-chloroalanine into pyruvate. Is also able to rapidly convert vinylglycine to threonine, which proves that the pyridoxal p-quinonoid of vinylglycine is an intermediate in the TS reaction
C1_03224	469008.B21_00003	3.4e-177	627.5	Escherichia	thrB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000			iECSE_1348.ECSE_0003,iJN678.thrB,iLJ478.TM0545,iSB619.SA_RS06620	Bacteria	1MW8I@1224,1RMYR@1236,3XN01@561,COG0083@1,COG0083@2	NA|NA|NA	F	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
C1_03225	469008.B21_00002	0.0	1597.0	Escherichia	thrA	GO:0003674,GO:0003824,GO:0004072,GO:0004412,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009085,GO:0009089,GO:0009090,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.3,2.7.2.4	ko:K00003,ko:K00928,ko:K12524,ko:K12525	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000			iECDH1ME8569_1439.ECDH1ME8569_0002,iECED1_1282.ECED1_4739,iEcDH1_1363.EcDH1_3594,iSFV_1184.SFV_0001,iUMNK88_1353.UMNK88_4778	Bacteria	1MW3H@1224,1RN1G@1236,3XN2A@561,COG0460@1,COG0460@2,COG0527@1,COG0527@2	NA|NA|NA	E	homoserine dehydrogenase I
C1_03226	198214.SF4434	1.9e-121	441.8	Gammaproteobacteria	trmJ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.1.1.200	ko:K02533,ko:K15396					ko00000,ko01000,ko03016				Bacteria	1MUKP@1224,1RMZX@1236,COG0565@1,COG0565@2	NA|NA|NA	J	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C1_03227	1440052.EAKF1_ch1423	5.1e-133	480.3	Escherichia													Bacteria	1MWJG@1224,1RPU3@1236,3XN3D@561,COG0745@1,COG0745@2	NA|NA|NA	K	It also may be involved in the osmoregulation of envelope proteins. When activated by ArcB, it negatively regulates the expression of genes of aerobic function. Activates the transcription of the plfB operon by binding to its promoter
C1_03228	469008.B21_04241	7.4e-250	869.4	Escherichia	creD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K06143					ko00000				Bacteria	1MVVR@1224,1RQRZ@1236,3XMF1@561,COG4452@1,COG4452@2	NA|NA|NA	V	Inner membrane protein CreD
C1_03229	362663.ECP_4785	1.7e-260	904.8	Escherichia													Bacteria	1N17V@1224,1RPVU@1236,3XM7C@561,COG0642@1,COG2205@2	NA|NA|NA	T	PhoQ Sensor
C1_03230	469008.B21_04239	1.2e-126	459.1	Escherichia													Bacteria	1MVCB@1224,1S179@1236,3XPC1@561,COG0745@1,COG0745@2	NA|NA|NA	K	Transcriptional regulatory protein, C terminal
C1_03231	155864.EDL933_5741	2.3e-81	308.1	Escherichia	creA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K05805					ko00000				Bacteria	1RDMP@1224,1S29X@1236,3XNHF@561,COG3045@1,COG3045@2	NA|NA|NA	S	CreA protein
C1_03232	155864.EDL933_5740	1.2e-168	599.0	Escherichia	rob	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006089,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009438,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019172,GO:0019243,GO:0019249,GO:0019752,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0043565,GO:0044237,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0046394,GO:0051596,GO:0061727,GO:0071704,GO:0072330,GO:0097159,GO:1901363,GO:1901575,GO:1901576,GO:1901615,GO:1901617		ko:K05804,ko:K13653		M00647,M00767			ko00000,ko00002,ko03000,ko03036				Bacteria	1MWTF@1224,1RQMF@1236,3XMHC@561,COG2207@1,COG2207@2,COG3708@1,COG3708@2	NA|NA|NA	K	Binds to the right arm of the replication origin oriC of the chromosome. Rob binding may influence the formation of the nucleoprotein structure, required for oriC function in the initiation of replication
C1_03233	155864.EDL933_5739	2.1e-117	428.3	Escherichia	gpmB		5.4.2.12	ko:K15634	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000			iZ_1308.Z5997	Bacteria	1NPC4@1224,1RSEU@1236,3XN8A@561,COG0406@1,COG0406@2	NA|NA|NA	F	Belongs to the phosphoglycerate mutase family. GpmB subfamily
C1_03234	316407.85677133	1e-90	339.3	Escherichia	yjjX	GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0017144,GO:0034641,GO:0042723,GO:0044237,GO:0044281,GO:0046483,GO:0071704,GO:0072527,GO:1901360,GO:1901564										iECO111_1330.ECO111_5255	Bacteria	1R60T@1224,1RNVT@1236,3XM8I@561,COG1986@1,COG1986@2	NA|NA|NA	F	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
C1_03235	155864.EDL933_5737	3e-47	194.1	Escherichia	trpR	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006355,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009072,GO:0009308,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0019752,GO:0031323,GO:0031326,GO:0034641,GO:0042430,GO:0043436,GO:0043565,GO:0044106,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0140110,GO:1901360,GO:1901363,GO:1901564,GO:1901605,GO:1903506,GO:2000112,GO:2001141		ko:K03720					ko00000,ko03000				Bacteria	1MYB2@1224,1S6RH@1236,3XPUK@561,COG2973@1,COG2973@2	NA|NA|NA	K	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
C1_03236	155864.EDL933_5736	0.0	1282.7	Escherichia	slt	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008932,GO:0008933,GO:0009056,GO:0009057,GO:0009253,GO:0009274,GO:0016740,GO:0016757,GO:0030203,GO:0030288,GO:0030312,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575		ko:K08309					ko00000,ko01000,ko01011		GH23	iETEC_1333.ETEC_4747,iPC815.YPO0452	Bacteria	1MV3F@1224,1RMS8@1236,3XMM5@561,COG0741@1,COG0741@2	NA|NA|NA	M	Murein-degrading enzyme. Catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N- acetylglucosamine residues in peptidoglycan. May play a role in recycling of muropeptides during cell elongation and or cell division
C1_03237	155864.EDL933_5735	0.0	1094.7	Escherichia	yjjK	GO:0003674,GO:0003824,GO:0005488,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:2000112,GO:2000113	3.6.3.25	ko:K06020					ko00000,ko01000				Bacteria	1MU37@1224,1RPWS@1236,3XN7U@561,COG0488@1,COG0488@2	NA|NA|NA	S	A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P site) into the translation elongation cycle by using a mechanism sensitive to the ATP ADP ratio. Binds to the 70S ribosome E site where it modulates the state of the translating ribosome during subunit translocation
C1_03238	469008.B21_04231	6.3e-240	836.3	Escherichia	nadR	GO:0000166,GO:0000287,GO:0000309,GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005524,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009268,GO:0009435,GO:0009628,GO:0009987,GO:0010035,GO:0010038,GO:0010446,GO:0016043,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0022607,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043565,GO:0043933,GO:0044085,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0046872,GO:0050896,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051716,GO:0055086,GO:0065003,GO:0070566,GO:0070887,GO:0071241,GO:0071248,GO:0071704,GO:0071840,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990837	2.7.1.22,2.7.7.1	ko:K06211	ko00760,ko01100,map00760,map01100		R00137,R02324,R03005	RC00002,RC00017	ko00000,ko00001,ko01000,ko03000			iECSE_1348.ECSE_4665,iYL1228.KPN_04845	Bacteria	1MUSI@1224,1RPHP@1236,3XNA4@561,COG1056@1,COG1056@2,COG3172@1,COG3172@2	NA|NA|NA	H	This enzyme has three activities DNA binding, nicotinamide mononucleotide (NMN) adenylyltransferase and ribosylnicotinamide (RN) kinase. The DNA-binding domain binds to the nadB operator sequence in an NAD- and ATP-dependent manner. As NAD levels increase within the cell, the affinity of NadR for the nadB operator regions of nadA, nadB, and pncB increases, repressing the transcription of these genes. The RN kinase activity catalyzes the phosphorylation of RN to form nicotinamide ribonucleotide. The NMN adenylyltransferase activity catalyzes the transfer of the AMP moiety of ATP to nicotinamide ribonucleotide to form NAD( ). The NMN adenylyltransferase domain also functions as the NAD and ATP sensor
C1_03239	1440052.EAKF1_ch1436c	1.1e-256	892.1	Escherichia	radA	GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363		ko:K04485					ko00000,ko03400				Bacteria	1MUJQ@1224,1RN2E@1236,3XNG4@561,COG1066@1,COG1066@2	NA|NA|NA	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C1_03240	155864.EDL933_5731	1.2e-180	639.0	Escherichia	serB	GO:0000287,GO:0001505,GO:0003674,GO:0003824,GO:0004647,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006563,GO:0006564,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0017144,GO:0019752,GO:0042133,GO:0042136,GO:0042578,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046872,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009			iE2348C_1286.E2348C_4686,iEC042_1314.EC042_4885,iECO26_1355.ECO26_5594,iECSF_1327.ECSF_4321,iECUMN_1333.ECUMN_5012,iETEC_1333.ETEC_4743,iPC815.YPO0442,iUMNK88_1353.UMNK88_5307	Bacteria	1MWA3@1224,1RNJE@1236,3XP59@561,COG0560@1,COG0560@2	NA|NA|NA	E	Catalyzes the dephosphorylation of phosphoserine (P- Ser)
C1_03241	155864.EDL933_5730	2.1e-109	401.7	Escherichia	lplA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0016874,GO:0016879,GO:0016979,GO:0017118,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:0140096,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.4.1.15,2.4.1.347,2.7.13.3,6.3.1.20	ko:K00697,ko:K03800,ko:K07186,ko:K20973	ko00500,ko00785,ko01100,ko02020,ko02025,map00500,map00785,map01100,map02020,map02025	M00820	R02737,R07770,R07771,R11143	RC00005,RC00043,RC00049,RC00070,RC00090,RC00992,RC02748,RC02896	ko00000,ko00001,ko00002,ko01000,ko01001,ko01003,ko02022		GT20	iBWG_1329.BWG_4078,iE2348C_1286.E2348C_4684,iECDH10B_1368.ECDH10B_4544,iECDH1ME8569_1439.ECDH1ME8569_4242,iEcDH1_1363.EcDH1_3612,iJO1366.b4386,iSDY_1059.SDY_4647,iY75_1357.Y75_RS22890	Bacteria	1N1T8@1224,1RMGI@1236,3XMVY@561,COG0095@1,COG0095@2,COG3726@1,COG3726@2	NA|NA|NA	J	Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes
C1_03242	469008.B21_04227	7.4e-194	682.9	Escherichia	lplA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0016874,GO:0016879,GO:0016979,GO:0017118,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:0140096,GO:1901360,GO:1901362,GO:1901564,GO:1901576	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100		R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000			iBWG_1329.BWG_4078,iE2348C_1286.E2348C_4684,iECDH10B_1368.ECDH10B_4544,iECDH1ME8569_1439.ECDH1ME8569_4242,iEcDH1_1363.EcDH1_3612,iJO1366.b4386,iSDY_1059.SDY_4647,iY75_1357.Y75_RS22890	Bacteria	1N1T8@1224,1RMGI@1236,3XMVY@561,COG0095@1,COG0095@2	NA|NA|NA	J	Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes
C1_03243	155864.EDL933_5729	2.6e-15	87.0	Gammaproteobacteria													Bacteria	1QSGY@1224,1SQS7@1236,2FAMZ@1,342VS@2	NA|NA|NA	K	Helix-turn-helix
C1_03244	155864.EDL933_5728	2.5e-132	478.0	Escherichia	deoD	GO:0003674,GO:0003824,GO:0004731,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006152,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009116,GO:0009164,GO:0009987,GO:0015949,GO:0016740,GO:0016757,GO:0016763,GO:0019439,GO:0019686,GO:0033554,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042802,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658	2.4.2.1,2.4.2.28	ko:K00772,ko:K03784	ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,map00230,map00240,map00270,map00760,map01100,map01110	M00034	R01402,R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122,RC02819	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_1997,iB21_1397.B21_04226,iE2348C_1286.E2348C_4682,iEC042_1314.EC042_4881,iECABU_c1320.ECABU_c50190,iECBD_1354.ECBD_3636,iECB_1328.ECB_04260,iECD_1391.ECD_04260,iECED1_1282.ECED1_5255,iECIAI39_1322.ECIAI39_4916,iECNA114_1301.ECNA114_4626,iECO26_1355.ECO26_5590,iECOK1_1307.ECOK1_4950,iECP_1309.ECP_4768,iEcolC_1368.EcolC_3672,iLF82_1304.LF82_0467,iNRG857_1313.NRG857_22170,iSFV_1184.SFV_4418,iSF_1195.SF4416,iSFxv_1172.SFxv_4809,iS_1188.S4687,iUMN146_1321.UM146_22680,iUMNK88_1353.UMNK88_5303,iUTI89_1310.UTI89_C5155,ic_1306.c5468	Bacteria	1MUW6@1224,1RMMA@1236,3XP9J@561,COG0813@1,COG0813@2	NA|NA|NA	F	Purine nucleoside phosphorylase
C1_03245	155864.EDL933_5727	6.7e-242	842.8	Escherichia	deoB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008973,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	5.4.2.7	ko:K01839	ko00030,ko00230,map00030,map00230		R01057,R02749	RC00408	ko00000,ko00001,ko01000			iLF82_1304.LF82_0465,iNRG857_1313.NRG857_22165	Bacteria	1MVN8@1224,1RQ6W@1236,3XMQS@561,COG1015@1,COG1015@2	NA|NA|NA	F	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C1_03246	1440052.EAKF1_ch1443c	5e-243	846.7	Escherichia	deoA	GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009032,GO:0009116,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0016763,GO:0033554,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072527,GO:1901135,GO:1901360,GO:1901564,GO:1901657	2.4.2.2,2.4.2.4	ko:K00756,ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219		R01570,R01876,R02296,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000			iB21_1397.B21_04224,iEC042_1314.EC042_4879,iECBD_1354.ECBD_3638,iECB_1328.ECB_04258,iECD_1391.ECD_04258,iECH74115_1262.ECH74115_5897,iECIAI1_1343.ECIAI1_4605,iECIAI39_1322.ECIAI39_4914,iECSE_1348.ECSE_4657,iECSP_1301.ECSP_5465,iECUMN_1333.ECUMN_5006,iECW_1372.ECW_m4744,iEKO11_1354.EKO11_3932,iETEC_1333.ETEC_4738,iEcE24377_1341.EcE24377A_4981,iEcSMS35_1347.EcSMS35_4931,iEcolC_1368.EcolC_3674,iG2583_1286.G2583_5242,iSSON_1240.SSON_4533,iSbBS512_1146.SbBS512_E4929,iUMNK88_1353.UMNK88_5301,iWFL_1372.ECW_m4744,iYL1228.KPN_04838,iZ_1308.Z5984,ic_1306.c5466	Bacteria	1MV3H@1224,1RPTG@1236,3XNQE@561,COG0213@1,COG0213@2	NA|NA|NA	F	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C1_03247	155864.EDL933_5725	1e-139	502.7	Escherichia	deoC	GO:0003674,GO:0003824,GO:0004139,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0015949,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	4.1.2.4	ko:K01619	ko00030,map00030		R01066	RC00436,RC00437	ko00000,ko00001,ko01000			iEcSMS35_1347.EcSMS35_4930,iPC815.YPO0436	Bacteria	1N8AG@1224,1RPTS@1236,3XMSF@561,COG0274@1,COG0274@2	NA|NA|NA	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C1_03248	316407.85677119	2.8e-301	1040.4	Escherichia	yjjI	GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0044237,GO:0045333,GO:0055114											Bacteria	1N1EN@1224,1RP1S@1236,3XMK1@561,COG1328@1,COG1328@2	NA|NA|NA	F	anaerobic respiration
C1_03249	316407.85677118	2.2e-151	541.6	Escherichia	yjjW		1.97.1.4	ko:K04069			R04710		ko00000,ko01000				Bacteria	1QIC8@1224,1RRCB@1236,3XPBI@561,COG1180@1,COG1180@2	NA|NA|NA	O	4 iron, 4 sulfur cluster binding
C1_03250	481805.EcolC_3678	2.9e-142	511.1	Escherichia	yjjV			ko:K03424					ko00000,ko01000				Bacteria	1MW5C@1224,1RP5T@1236,3XP1T@561,COG0084@1,COG0084@2	NA|NA|NA	L	endodeoxyribonuclease activity, producing 5'-phosphomonoesters
C1_03251	316407.85677116	3.6e-207	727.2	Escherichia	yjjU	GO:0003674,GO:0003824,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016787,GO:0033554,GO:0050896,GO:0051716											Bacteria	1PV7M@1224,1RRPR@1236,3XNUQ@561,COG4667@1,COG4667@2	NA|NA|NA	S	lipid catabolic process
C1_03252	1218086.BBNB01000016_gene1658	1.3e-17	94.7	Citrobacter	ytjA												Bacteria	1NGAH@1224,1SGD7@1236,3WYW6@544,COG5487@1,COG5487@2	NA|NA|NA	S	Protein of unknown function (DUF1328)
C1_03253	199310.c5457	1.5e-98	365.5	Escherichia	osmY	GO:0005575,GO:0005623,GO:0006457,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0009628,GO:0009987,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0050896,GO:0061077		ko:K04065					ko00000				Bacteria	1PCIJ@1224,1RRGP@1236,3XN0N@561,COG2823@1,COG2823@2	NA|NA|NA	S	hyperosmotic response
C1_03254	362663.ECP_4758	0.0	1076.2	Escherichia	prfC	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016150,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019538,GO:0022411,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032984,GO:0034641,GO:0034645,GO:0036094,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576		ko:K02837					ko00000,ko03012				Bacteria	1MU7X@1224,1RMFT@1236,3XNAI@561,COG4108@1,COG4108@2	NA|NA|NA	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C1_03255	199310.c5454	4e-127	460.7	Escherichia	yjjG	GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006206,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008655,GO:0009058,GO:0009112,GO:0009410,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019856,GO:0019859,GO:0030145,GO:0034641,GO:0034654,GO:0042221,GO:0042578,GO:0043094,GO:0043100,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046112,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.1.3.102,3.1.3.104,3.1.3.5,3.8.1.2	ko:K01560,ko:K07025,ko:K08723,ko:K20862	ko00230,ko00240,ko00361,ko00625,ko00740,ko00760,ko01100,ko01110,ko01120,map00230,map00240,map00361,map00625,map00740,map00760,map01100,map01110,map01120	M00125	R00183,R00511,R00548,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346,R05287,R07280	RC00017,RC00697	ko00000,ko00001,ko00002,ko01000			iECNA114_1301.ECNA114_4614	Bacteria	1MVF8@1224,1RMK3@1236,3XNKE@561,COG1011@1,COG1011@2	NA|NA|NA	S	Nucleotidase that shows high phosphatase activity toward non-canonical pyrimidine nucleotides and three canonical nucleoside 5'-monophosphates (UMP, dUMP, and dTMP), and very low activity against TDP, IMP, UDP, GMP, dGMP, AMP, dAMP, and 6- phosphogluconate. Appears to function as a house-cleaning nucleotidase in vivo, since the general nucleotidase activity of YjjG allows it to protect cells against non-canonical pyrimidine derivatives such as 5-fluoro-2'-deoxyuridine, 5-fluorouridine, 5- fluoroorotate, 5-fluorouracil, and 5-aza-2'-deoxycytidine, and prevents the incorporation of potentially mutagenic nucleotides into DNA. Its dUMP phosphatase activity that catalyzes the hydrolysis of dUMP to deoxyuridine is necessary for thymine utilization via the thymine salvage pathway. Is strictly specific to substrates with 5'-phosphates and shows no activity against nucleoside 2'- or 3'-monophosphates
C1_03256	155864.EDL933_5714	9.4e-77	292.7	Escherichia	rimI	GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008999,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0017189,GO:0018193,GO:0018194,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564	2.3.1.128,2.3.1.234	ko:K01409,ko:K03789,ko:K14742			R10648	RC00070,RC00416	ko00000,ko01000,ko03009,ko03016				Bacteria	1RIE6@1224,1S9G0@1236,3XN7X@561,COG0454@1,COG0456@2	NA|NA|NA	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18
C1_03257	155864.EDL933_5713	2.4e-71	274.6	Escherichia	holD	GO:0008150,GO:0009314,GO:0009628,GO:0050896	2.7.7.7	ko:K02344	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Bacteria	1RH2F@1224,1S634@1236,3XPMT@561,COG3050@1,COG3050@2	NA|NA|NA	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
C1_03258	481805.EcolC_3686	3.4e-194	684.1	Escherichia	rsmC	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052914,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.172,2.1.1.174	ko:K00564,ko:K11391			R07234	RC00003	ko00000,ko01000,ko03009				Bacteria	1MXE9@1224,1RQCH@1236,3XP64@561,COG2813@1,COG2813@2	NA|NA|NA	J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle
C1_03262	198214.SF4401	3.6e-35	153.7	Gammaproteobacteria	yjjZ												Bacteria	1N033@1224,1SC0F@1236,2CF73@1,32RSY@2	NA|NA|NA	S	Protein of unknown function (DUF1435)
C1_03263	481805.EcolC_3688	1.8e-147	528.5	Escherichia	fhuF	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0009987,GO:0016020,GO:0019725,GO:0030003,GO:0033212,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0051536,GO:0051537,GO:0051540,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071944,GO:0098771		ko:K13255					ko00000			iE2348C_1286.E2348C_4666,iECH74115_1262.ECH74115_5880,iECNA114_1301.ECNA114_4609,iECSP_1301.ECSP_5450,iECs_1301.ECs5327,iG2583_1286.G2583_5169,iSBO_1134.SBO_4427,iZ_1308.Z5968	Bacteria	1MWSR@1224,1RSNM@1236,3XNBX@561,COG4114@1,COG4114@2	NA|NA|NA	S	ferric iron reductase
C1_03264	155864.EDL933_5709	2.1e-120	438.3	Escherichia	bglJ	GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009314,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141		ko:K07781	ko02020,ko02024,ko02026,map02020,map02024,map02026				ko00000,ko00001,ko03000				Bacteria	1RBIN@1224,1S2HI@1236,3XMED@561,COG2197@1,COG2197@2	NA|NA|NA	K	Transcriptional activator protein BglJ
C1_03265	155864.EDL933_5708	7.5e-132	476.5	Escherichia	yjjQ	GO:0008150,GO:0010033,GO:0042221,GO:0050896,GO:0051595,GO:1901654,GO:1901700		ko:K07781	ko02020,ko02024,ko02026,map02020,map02024,map02026				ko00000,ko00001,ko03000				Bacteria	1MWAP@1224,1RQ0X@1236,3XMZU@561,COG2197@1,COG2197@2	NA|NA|NA	K	response to methylglyoxal
C1_03266	198214.SF4395	4e-153	547.4	Gammaproteobacteria	yjjP	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0008150,GO:0015711,GO:0015740,GO:0015744,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071944											Bacteria	1NH2X@1224,1RN1Q@1236,COG2966@1,COG2966@2	NA|NA|NA	S	Membrane
C1_03267	481805.EcolC_3692	1.6e-79	302.0	Escherichia	yjjB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006950,GO:0006970,GO:0008150,GO:0009628,GO:0010033,GO:0010243,GO:0015711,GO:0015740,GO:0015744,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0042221,GO:0042493,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071944,GO:1901652,GO:1901698,GO:1901700											Bacteria	1RAWK@1224,1S2KX@1236,3XN8X@561,COG3610@1,COG3610@2	NA|NA|NA	S	response to peptide
C1_03268	198214.SF4393	2.2e-96	358.2	Gammaproteobacteria	dnaT	GO:0003674,GO:0005488,GO:0005515,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006267,GO:0006725,GO:0006807,GO:0007049,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0022402,GO:0022607,GO:0033260,GO:0034622,GO:0034641,GO:0034645,GO:0036388,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044786,GO:0046483,GO:0065003,GO:0065004,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:1901360,GO:1901576,GO:1902299		ko:K02317	ko03440,map03440				ko00000,ko00001,ko03400				Bacteria	1PJ9A@1224,1RYK1@1236,28IQ3@1,2Z8PW@2	NA|NA|NA	L	it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'
C1_03269	155864.EDL933_5704	7.3e-135	486.5	Escherichia	dnaC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0022616,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576		ko:K02315,ko:K10762					ko00000,ko03032				Bacteria	1MZNW@1224,1RQFW@1236,3XMDA@561,COG1484@1,COG1484@2	NA|NA|NA	L	This protein is required for chromosomal replication. It forms, in concert with DnaB protein and other prepriming proteins DnaT, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'
C1_03270	316407.85677100	3.1e-81	307.8	Escherichia	yjjA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Bacteria	1N1I7@1224,1S9J1@1236,2B7M6@1,320SA@2,3XPG7@561	NA|NA|NA	S	Protein of unknown function (DUF2501)
C1_03271	199310.c5438	0.0	1550.8	Escherichia	mdoB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006490,GO:0006629,GO:0008150,GO:0008152,GO:0008960,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0042597,GO:0044237,GO:0044238,GO:0044255,GO:0044464,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576	2.7.8.20	ko:K01002	ko01100,map01100				ko00000,ko01000				Bacteria	1MVCM@1224,1RNJ3@1236,3XP4B@561,COG1368@1,COG1368@2	NA|NA|NA	M	Transfers a phosphoglycerol residue from phosphatidylglycerol to the membrane-bound nascent glucan backbones
C1_03272	316407.85677098	8.2e-193	679.5	Escherichia	yjjN	GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019520,GO:0019583,GO:0019584,GO:0019752,GO:0032787,GO:0034193,GO:0034195,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	1.1.1.1,1.1.1.58	ko:K00001,ko:K00041	ko00010,ko00040,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00040,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	M00631	R00623,R00754,R02124,R02555,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00085,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko00002,ko01000			iSSON_1240.SSON_4504	Bacteria	1MWX0@1224,1RR1W@1236,3XQDT@561,COG1063@1,COG1063@2	NA|NA|NA	C	Catalyzes the oxidation of L-galactonate to D- tagaturonate. Required for growth on L-galactonate as the sole carbon source. In vitro, can also use L-gulonate
C1_03273	155864.EDL933_5700	3e-170	604.4	Escherichia	yjjM	GO:0005975,GO:0006082,GO:0006355,GO:0008150,GO:0008152,GO:0009056,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016052,GO:0016054,GO:0019219,GO:0019222,GO:0019520,GO:0019583,GO:0019584,GO:0019752,GO:0031323,GO:0031326,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046395,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0072329,GO:0080090,GO:1901575,GO:1903506,GO:2000112,GO:2001141											Bacteria	1R56F@1224,1RNQY@1236,3XQ5A@561,COG1802@1,COG1802@2	NA|NA|NA	K	Transcriptional regulator
C1_03274	481805.EcolC_3699	1.1e-256	892.1	Escherichia	yjjL	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008643,GO:0015711,GO:0015718,GO:0015849,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0034219,GO:0034220,GO:0042873,GO:0044425,GO:0044464,GO:0046942,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098656,GO:1903825,GO:1905039											Bacteria	1MVPS@1224,1RPRB@1236,3XP6M@561,COG2271@1,COG2271@2	NA|NA|NA	P	Probably responsible for the transport of L-galactonate from the periplasm across the inner membrane. Is essential for growth on L-galactonate as the sole carbon source
C1_03275	469008.B21_04198	7.7e-249	866.3	Escherichia	tsr	GO:0001101,GO:0001932,GO:0003674,GO:0004888,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006928,GO:0006935,GO:0007154,GO:0007165,GO:0007172,GO:0008104,GO:0008150,GO:0009593,GO:0009605,GO:0009719,GO:0009966,GO:0009987,GO:0010033,GO:0010243,GO:0010646,GO:0016020,GO:0016021,GO:0016043,GO:0019220,GO:0019222,GO:0019899,GO:0019900,GO:0019901,GO:0022607,GO:0023051,GO:0023052,GO:0031224,GO:0031226,GO:0031323,GO:0031399,GO:0032101,GO:0032110,GO:0032268,GO:0032879,GO:0032991,GO:0033036,GO:0034613,GO:0034622,GO:0038023,GO:0040011,GO:0040012,GO:0042221,GO:0042325,GO:0042330,GO:0042802,GO:0042803,GO:0043113,GO:0043200,GO:0043424,GO:0043549,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045859,GO:0046983,GO:0048583,GO:0048870,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0050920,GO:0051171,GO:0051174,GO:0051179,GO:0051246,GO:0051259,GO:0051260,GO:0051270,GO:0051338,GO:0051606,GO:0051641,GO:0051668,GO:0051674,GO:0051716,GO:0060089,GO:0060255,GO:0065003,GO:0065007,GO:0065009,GO:0070727,GO:0070887,GO:0071229,GO:0071230,GO:0071310,GO:0071417,GO:0071495,GO:0071840,GO:0071944,GO:0072657,GO:0080090,GO:0098561,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902021,GO:2000145		ko:K03406,ko:K05874,ko:K05875,ko:K05876,ko:K05877	ko02020,ko02030,map02020,map02030				ko00000,ko00001,ko02035				Bacteria	1MU9B@1224,1RMH0@1236,3XNKT@561,COG0840@1,COG0840@2	NA|NA|NA	NT	Methyl-accepting chemotaxis protein
C1_03276	199310.c5429	0.0	1409.4	Escherichia	cstA	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:0071944		ko:K06200					ko00000				Bacteria	1MWF9@1224,1RMG4@1236,3XMEQ@561,COG1966@1,COG1966@2	NA|NA|NA	T	Part of a nutrient-sensing regulatory network composed of the two-component regulatory systems BtsS BtsR and YpdA YpdB, and their respective target proteins, YjiY and YhjX
C1_03277	1440052.EAKF1_ch1494	1.7e-33	147.9	Escherichia	yjiX	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716											Bacteria	1N6TY@1224,1S8VA@1236,3XR4J@561,COG2879@1,COG2879@2	NA|NA|NA	S	Selenoprotein, putative
C1_03278	155864.EDL933_5694	5.1e-181	640.2	Escherichia	yjiA	GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0033554,GO:0042802,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716											Bacteria	1MVZV@1224,1RQDY@1236,3XNSG@561,COG0523@1,COG0523@2	NA|NA|NA	S	GTPase activity
C1_03279	469008.B21_04183	6.7e-170	603.2	Escherichia	mrr	GO:0001101,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009295,GO:0009415,GO:0009628,GO:0009987,GO:0010035,GO:0015666,GO:0016787,GO:0016788,GO:0032067,GO:0034641,GO:0042221,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051599,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901700		ko:K07448					ko00000,ko02048				Bacteria	1Q2VY@1224,1RYEE@1236,3XQ4J@561,COG1715@1,COG1715@2	NA|NA|NA	J	Involved in the acceptance of foreign DNA which is modified. Restricts both adenine- and cytosine-methylated DNA
C1_03280	1440052.EAKF1_ch1497	0.0	2261.1	Escherichia	hsdR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	3.1.21.3	ko:K01153					ko00000,ko01000,ko02048				Bacteria	1QTS7@1224,1RN63@1236,3XQUG@561,COG4096@1,COG4096@2	NA|NA|NA	L	The EcoKI enzyme recognizes 5'-AACN(6)GTGC-3'. Subunit R is required for both nuclease and ATPase activities, but not for modification
C1_03281	316407.85677089	6.6e-311	1072.4	Escherichia	hsdM	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464	2.1.1.72	ko:K03427					ko00000,ko01000,ko02048				Bacteria	1MW3A@1224,1RRVF@1236,3XRHX@561,COG0286@1,COG0286@2	NA|NA|NA	J	The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of a bipartite DNA recognition sequence. In the presence of the R subunit the complex can also act as an endonuclease, binding to the same target sequence but cutting the DNA some distance from this site. Whether the DNA is cut or modified depends on the methylation state of the target sequence. When the target site is unmodified, the DNA is cut. When the target site is hemimethylated, the complex acts as a maintenance MTase modifying the DNA so that both strands become methylated. The EcoKI enzyme recognizes 5'-AACN(6)GTGC-3'
C1_03282	572544.Ilyop_0907	7.5e-70	271.6	Fusobacteria			3.1.21.3	ko:K01154					ko00000,ko01000,ko02048				Bacteria	378P5@32066,COG0732@1,COG0732@2	NA|NA|NA	L	Type I restriction modification DNA specificity domain
C1_03283	1440052.EAKF1_ch1500	5.5e-53	213.4	Escherichia	symE	GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009432,GO:0009605,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0019222,GO:0019439,GO:0031668,GO:0033554,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575		ko:K19048					ko00000,ko02048				Bacteria	1RIS1@1224,1S7E6@1236,2DM63@1,31VID@2,3XQ5J@561	NA|NA|NA	J	Involved in the degradation and recycling of damaged RNA. It is itself a target for degradation by the ATP-dependent protease Lon
C1_03284	469008.B21_04176	5.3e-267	926.4	Escherichia	mcrB	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003924,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0015666,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0017111,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901361,GO:1901363,GO:1901575		ko:K07452					ko00000,ko01000,ko02048				Bacteria	1MYQM@1224,1RSU7@1236,3XR9B@561,COG1401@1,COG1401@2	NA|NA|NA	L	also binds to GTP. Isoform 33 kDa is less active than isoform 51 kDa and may play a role in regulating the activity of isoform 51 kDa by competing with it in DNA and protein binding abilities
C1_03285	316407.85677085	5.8e-194	683.3	Gammaproteobacteria	mcrC			ko:K19147					ko00000,ko02048				Bacteria	1R1FP@1224,1RZIR@1236,COG4268@1,COG4268@2	NA|NA|NA	V	DNA restriction-modification system
C1_03286	630626.EBL_c34740	0.0	3927.1	Gammaproteobacteria				ko:K06877					ko00000				Bacteria	1MVGH@1224,1RQXN@1236,COG1201@1,COG1201@2,COG1205@1,COG1205@2	NA|NA|NA	L	dEAD DEAH box helicase
C1_03287	1524467.IV04_11700	0.0	1755.0	Gammaproteobacteria													Bacteria	1MWES@1224,1RSKN@1236,28ICC@1,2Z8ER@2	NA|NA|NA		
C1_03288	155864.EDL933_5685	2.7e-21	107.1	Escherichia	yjiS												Bacteria	1NKWS@1224,1SHB3@1236,3XRBS@561,COG5457@1,COG5457@2	NA|NA|NA	S	Domain of unknown function (DUF1127)
C1_03289	316407.85677082	1.2e-274	951.8	Escherichia	yjiR	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576											Bacteria	1MV6F@1224,1RMQ0@1236,3XQJT@561,COG1167@1,COG1167@2	NA|NA|NA	K	transaminase activity
C1_03290	754331.AEME01000001_gene2196	1.6e-166	592.0	Escherichia	rpnD												Bacteria	1MUSP@1224,1RNUW@1236,3XNRC@561,COG5464@1,COG5464@2	NA|NA|NA	S	Putative transposase, YhgA-like
C1_03291	155864.EDL933_5680	3.8e-221	773.9	Escherichia	mdtM	GO:0003674,GO:0005215,GO:0005451,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006814,GO:0006855,GO:0006873,GO:0006885,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015079,GO:0015081,GO:0015238,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015307,GO:0015318,GO:0015385,GO:0015386,GO:0015491,GO:0015672,GO:0015893,GO:0016020,GO:0019725,GO:0022804,GO:0022821,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030004,GO:0030641,GO:0034220,GO:0035725,GO:0042221,GO:0042493,GO:0042592,GO:0044464,GO:0046618,GO:0046677,GO:0046873,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051234,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099516,GO:1902600		ko:K08160					ko00000,ko01504,ko02000	2.A.1.2.19		iSFV_1184.SFV_0827	Bacteria	1MUWH@1224,1RRF6@1236,3XQTZ@561,COG0477@1,COG2814@2	NA|NA|NA	P	Confers resistance to acriflavine, chloramphenicol, norfloxacin, ethidium bromide and TPP
C1_03292	362663.ECP_4672	3.2e-234	817.4	Escherichia	yjiN	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1MX3G@1224,1RNR7@1236,3XMNE@561,COG2733@1,COG2733@2	NA|NA|NA	S	Protein of unknown function (DUF445)
C1_03293	199310.c5418	4.4e-219	766.9	Escherichia	yjiM	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716											Bacteria	1NNW9@1224,1RPEE@1236,3XNW9@561,COG1775@1,COG1775@2	NA|NA|NA	E	lyase activity
C1_03294	481805.EcolC_3729	1.8e-136	491.9	Escherichia	yjiL												Bacteria	1R6HU@1224,1RQ2H@1236,3XN6E@561,COG1924@1,COG1924@2	NA|NA|NA	I	4 iron, 4 sulfur cluster binding
C1_03295	155864.EDL933_5676	3.3e-45	187.2	Escherichia													Bacteria	1N7MK@1224,1SD2C@1236,2E4RX@1,32ZKF@2,3XQ34@561	NA|NA|NA	S	Protein of unknown function (DUF3343)
C1_03296	155864.EDL933_5675	1.6e-219	769.2	Escherichia													Bacteria	1N7U9@1224,1RYAA@1236,3XQPQ@561,COG1357@1,COG1357@2	NA|NA|NA	S	Pentapeptide repeats (9 copies)
C1_03297	155864.EDL933_5674	2.9e-151	541.2	Gammaproteobacteria	yjiK	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1NAG1@1224,1S2XD@1236,COG3204@1,COG3204@2	NA|NA|NA	S	SdiA-regulated
C1_03298	155864.EDL933_5673	1e-210	739.2	Escherichia	yjiJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1QWCC@1224,1T2TN@1236,3XQ4A@561,COG0477@1,COG0477@2	NA|NA|NA	EGP	Uncharacterised MFS-type transporter YbfB
C1_03299	155864.EDL933_5672	0.0	3011.9	Escherichia	lppY	GO:0007155,GO:0008150,GO:0009987,GO:0022610,GO:0031589,GO:0042710,GO:0043708,GO:0044764,GO:0051704,GO:0090605		ko:K13735	ko05100,map05100				ko00000,ko00001				Bacteria	1MX9S@1224,1RPK7@1236,3XN7T@561,COG1388@1,COG1388@2,COG2373@1,COG2373@2	NA|NA|NA	M	cell adhesion
C1_03300	198214.SF4187	2.6e-103	381.3	Gammaproteobacteria	kptA	GO:0003674,GO:0003824,GO:0016740,GO:0016772		ko:K07559					ko00000,ko01000,ko03016				Bacteria	1RD8B@1224,1S3U6@1236,COG1859@1,COG1859@2	NA|NA|NA	J	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
C1_03301	155864.EDL933_5668	1.5e-118	432.2	Escherichia	yjiH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1NP3U@1224,1RNFQ@1236,3XPX4@561,COG3366@1,COG3366@2	NA|NA|NA	S	Nucleoside recognition
C1_03302	155864.EDL933_5667	2.2e-76	291.6	Escherichia	yjiG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1R4W8@1224,1T006@1236,3XQ0K@561,COG0700@1,COG0700@2	NA|NA|NA	S	Nucleoside recognition
C1_03303	155864.EDL933_5666	1e-218	765.8	Escherichia	iadA			ko:K01305					ko00000,ko01000,ko01002				Bacteria	1MUPA@1224,1RNYU@1236,3XRN7@561,COG0044@1,COG0044@2	NA|NA|NA	E	Catalyzes the hydrolytic cleavage of a subset of L- isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation
C1_03304	316407.85677070	2.1e-168	598.2	Escherichia	yjiE	GO:0000976,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:1990837,GO:2000112,GO:2001141		ko:K21645					ko00000,ko03000				Bacteria	1R4QT@1224,1RR79@1236,3XQW2@561,COG0583@1,COG0583@2	NA|NA|NA	K	Protects cells from HOCl (hypochlorite) stress but not peroxide or diamide stress. Decreases the intracellular load of reactive oxygen species by up-regulating genes involved in methionine and cysteine biosynthesis and down-regulating Fur- regulated genes involved in iron acquisition. Has also been suggested to down-regulate expression of the flagellar regulon, decreasing motility, but this activity was not confirmed in a second study
C1_03305	316407.85677069	2.4e-68	264.6	Escherichia	iraD	GO:0000988,GO:0000989,GO:0003674,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0009889,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010605,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033554,GO:0042176,GO:0042177,GO:0043856,GO:0045893,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051248,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141		ko:K11897,ko:K21637		M00334			ko00000,ko00002,ko02044				Bacteria	1NQRH@1224,1SKQV@1236,3XR2S@561,COG3518@1,COG3518@2	NA|NA|NA	S	Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during oxidative stress. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway
C1_03306	198214.SF4195	7e-150	536.6	Proteobacteria	yjiC												Bacteria	1NQYJ@1224,2F0KM@1,33TP9@2	NA|NA|NA	S	Protein of unknown function (DUF2686)
C1_03307	316407.85677067	7.2e-141	506.5	Escherichia	uxuR	GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K05799,ko:K13637,ko:K19775					ko00000,ko03000				Bacteria	1MY1K@1224,1RMUE@1236,3XMVC@561,COG2186@1,COG2186@2	NA|NA|NA	K	Uxu operon transcriptional regulator
C1_03308	155864.EDL933_5658	3.4e-285	986.9	Escherichia	uxuB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005996,GO:0006063,GO:0006064,GO:0006082,GO:0008150,GO:0008152,GO:0008866,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019585,GO:0019752,GO:0032787,GO:0042839,GO:0042840,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046365,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	1.1.1.17,1.1.1.289,1.1.1.57,1.1.1.58,1.1.1.67,2.7.1.17	ko:K00009,ko:K00040,ko:K00041,ko:K00045,ko:K00854,ko:K19633	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014,M00061,M00631	R00868,R01639,R02454,R02555,R02703,R07346	RC00002,RC00085,RC00102,RC00538	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_2108,iECABU_c1320.ECABU_c17480,iECOK1_1307.ECOK1_4822,iUMN146_1321.UM146_22300,iUTI89_1310.UTI89_C5019	Bacteria	1MVZ7@1224,1RNIZ@1236,3XP48@561,COG0246@1,COG0246@2	NA|NA|NA	G	Belongs to the mannitol dehydrogenase family
C1_03309	198214.SF4198	1.4e-228	798.5	Gammaproteobacteria	uxuA	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005975,GO:0005996,GO:0006063,GO:0006064,GO:0006082,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008198,GO:0008927,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019585,GO:0019752,GO:0030145,GO:0032787,GO:0033554,GO:0042839,GO:0042840,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046365,GO:0046395,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:0072329,GO:1901575	4.2.1.8	ko:K01686	ko00040,ko01100,map00040,map01100	M00061	R05606	RC00543	ko00000,ko00001,ko00002,ko01000			iECED1_1282.ECED1_5204	Bacteria	1MWYD@1224,1RR0Q@1236,COG1312@1,COG1312@2	NA|NA|NA	G	Catalyzes the dehydration of D-mannonate
C1_03310	155864.EDL933_5656	6.2e-233	813.1	Escherichia	gntP	GO:0003674,GO:0005215,GO:0005342,GO:0005351,GO:0005402,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0008028,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0008643,GO:0015075,GO:0015077,GO:0015078,GO:0015128,GO:0015144,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015672,GO:0015711,GO:0015718,GO:0015849,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034219,GO:0034220,GO:0035429,GO:0042873,GO:0042879,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:1902600,GO:1903825,GO:1905039		ko:K03299,ko:K06155,ko:K16321					ko00000,ko02000	2.A.8,2.A.8.1.3,2.A.8.1.4		iSSON_1240.SSON_3547	Bacteria	1MVK2@1224,1RZUF@1236,3XQH8@561,COG2610@1,COG2610@2	NA|NA|NA	P	High-affinity gluconate transporter with fairly broad specificity, including low affinity for glucuronate, several disaccharides, and some hexoses, but not glucose
C1_03312	316407.85677063	8e-168	596.3	Escherichia	fimH	GO:0003674,GO:0005488,GO:0005537,GO:0005575,GO:0005623,GO:0007155,GO:0008150,GO:0009289,GO:0018995,GO:0022610,GO:0030246,GO:0033643,GO:0033644,GO:0036094,GO:0042995,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044218,GO:0044279,GO:0044464,GO:0048029		ko:K07350					ko00000,ko02035,ko02044				Bacteria	1NQXE@1224,1RQSD@1236,3XQAD@561,COG3539@1,COG3539@2	NA|NA|NA	NU	Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Adhesin responsible for the binding to D-mannose. It is laterally positioned at intervals in the structure of the type 1 fimbriae. In order to integrate FimH in the fimbriae FimF and FimG are needed
C1_03313	155864.EDL933_5654	8.4e-82	309.7	Escherichia	fimG	GO:0005575,GO:0005623,GO:0009289,GO:0042995,GO:0044464		ko:K07349					ko00000,ko02035,ko02044				Bacteria	1RC12@1224,1S36F@1236,3XPI2@561,COG3539@1,COG3539@2	NA|NA|NA	NU	Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Involved in the integration of FimH in the fimbriae
C1_03314	316407.85677061	1e-93	349.4	Escherichia	fimF	GO:0005575,GO:0005623,GO:0009289,GO:0042995,GO:0044464		ko:K07348					ko00000,ko02035,ko02044				Bacteria	1R6J8@1224,1S138@1236,3XN73@561,COG3539@1,COG3539@2	NA|NA|NA	NU	Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Involved in the integration of FimH in the fimbriae
C1_03315	199310.c5396	0.0	1767.3	Escherichia	fimD	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0009279,GO:0009297,GO:0009987,GO:0015267,GO:0015288,GO:0015473,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0022803,GO:0022829,GO:0022857,GO:0030030,GO:0030031,GO:0030312,GO:0030313,GO:0031975,GO:0043711,GO:0044085,GO:0044462,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071840,GO:0071944		ko:K07347	ko05133,map05133				ko00000,ko00001,ko02000,ko02035,ko02044	1.B.11.3			Bacteria	1MUHE@1224,1RMPU@1236,3XMHU@561,COG3188@1,COG3188@2	NA|NA|NA	NU	Outer membrane usher protein fimD
C1_03316	469008.B21_04147	3.5e-129	467.6	Escherichia	fimC	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006457,GO:0008150,GO:0009987,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044183,GO:0044464,GO:0061077		ko:K07346,ko:K07353,ko:K15540					ko00000,ko02035,ko02044,ko03110				Bacteria	1R3T9@1224,1RS56@1236,3XNMT@561,COG3121@1,COG3121@2	NA|NA|NA	NU	Required for the biogenesis of type 1 fimbriae. Binds and interact with FimH
C1_03317	316407.85677058	1.7e-90	338.6	Escherichia	fimI	GO:0008150,GO:0009297,GO:0009987,GO:0016043,GO:0022607,GO:0030030,GO:0030031,GO:0043711,GO:0044085,GO:0071840		ko:K07351					ko00000,ko02035				Bacteria	1R7X9@1224,1RYWH@1236,3XM9U@561,COG3539@1,COG3539@2	NA|NA|NA	NU	pilus assembly
C1_03318	198214.SF4208	4.1e-82	310.8	Gammaproteobacteria	fimA	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0007155,GO:0008150,GO:0009289,GO:0022610,GO:0042802,GO:0042995,GO:0044464		ko:K07345,ko:K07352	ko05133,map05133				ko00000,ko00001,ko02035,ko02044				Bacteria	1QI7Y@1224,1S07V@1236,COG3539@1,COG3539@2	NA|NA|NA	NU	Fimbrial protein
C1_03319	198214.SF4209	5.1e-110	403.7	Gammaproteobacteria	fimE	GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0015074,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:1901360		ko:K04763,ko:K07357,ko:K07358					ko00000,ko03036				Bacteria	1R585@1224,1RZIC@1236,COG4974@1,COG4974@2	NA|NA|NA	K	FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off
C1_03320	155864.EDL933_5647	4e-115	420.6	Escherichia	fimB	GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0015074,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360		ko:K07357					ko00000				Bacteria	1QUDQ@1224,1T1V1@1236,3XPS4@561,COG0582@1,COG0582@2	NA|NA|NA	K	FimB is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimB switches fimA on
C1_03322	316407.85677054	5.6e-140	503.4	Escherichia	lptD	GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0006869,GO:0008150,GO:0008509,GO:0008514,GO:0008643,GO:0009279,GO:0009987,GO:0010876,GO:0015075,GO:0015136,GO:0015144,GO:0015157,GO:0015267,GO:0015288,GO:0015318,GO:0015478,GO:0015711,GO:0015739,GO:0015772,GO:0015849,GO:0015920,GO:0016020,GO:0016021,GO:0016043,GO:0019867,GO:0022607,GO:0022803,GO:0022829,GO:0022857,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031975,GO:0033036,GO:0034219,GO:0034220,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045203,GO:0045229,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0061024,GO:0071702,GO:0071709,GO:0071840,GO:0071944,GO:0098656,GO:1901264,GO:1901505,GO:1903825,GO:1905039		ko:K04744,ko:K22110					ko00000,ko02000	1.B.35.1,1.B.35.2,1.B.42.1		iG2583_1286.G2583_0058,ic_1306.c5389	Bacteria	1RKI2@1224,1S6AC@1236,3XQDI@561,COG1452@1,COG1452@2	NA|NA|NA	M	Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria
C1_03323	198214.SF4212	2e-213	748.0	Gammaproteobacteria	nanM	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0016853,GO:0016854,GO:0016857,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464	5.1.3.24	ko:K17948					ko00000,ko01000				Bacteria	1PJCX@1224,1RS0N@1236,COG3055@1,COG3055@2	NA|NA|NA	M	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
C1_03324	316407.85677052	7.1e-194	682.9	Escherichia	nanS	GO:0006082,GO:0008150,GO:0008152,GO:0009987,GO:0019752,GO:0043436,GO:0044237,GO:0044281,GO:0071704		ko:K22111					ko00000				Bacteria	1QWCB@1224,1T2TM@1236,2DDQI@1,2ZIWU@2,3XRN6@561	NA|NA|NA	S	Probably catalyzes the hydrolysis of the 9-O-acetyl group of 9-O-acetyl-N-acetylneuraminate (Neu5,9Ac2). Is required for growth of E.coli on Neu5,9Ac2, an alternative sialic acid commonly found in mammalian host mucosal sites, in particular in the human intestine
C1_03325	362663.ECP_4641	2.7e-168	597.8	Escherichia				ko:K07454					ko00000				Bacteria	1NE0N@1224,1RNM6@1236,3XQ3Z@561,COG3440@1,COG3440@2	NA|NA|NA	V	HNH endonuclease
C1_03326	1052684.PPM_0228	1.9e-23	117.9	Paenibacillaceae	M1-386												Bacteria	1TR6T@1239,2711A@186822,28Q4F@1,2ZCMQ@2,4IRMP@91061	NA|NA|NA		
C1_03327	35703.DQ02_04690	0.0	1523.8	Citrobacter				ko:K06919					ko00000				Bacteria	1MVGY@1224,1RQ3K@1236,3WY6M@544,COG3378@1,COG3378@2,COG4643@1,COG4643@2	NA|NA|NA	L	D5 N terminal like
C1_03328	35703.DQ02_04695	3.7e-51	207.2	Citrobacter													Bacteria	1RESH@1224,1S5GH@1236,29W9N@1,30HV0@2,3WZIS@544	NA|NA|NA	S	Family of unknown function (DUF5375)
C1_03329	35703.DQ02_04700	1.4e-33	148.3	Citrobacter													Bacteria	1N4CH@1224,1SXBE@1236,2DYK4@1,32T5Q@2,3WZNF@544	NA|NA|NA		
C1_03330	35703.DQ02_04705	4.9e-97	360.5	Citrobacter													Bacteria	1RBRT@1224,1S21Y@1236,3WYX5@544,COG3646@1,COG3646@2	NA|NA|NA	S	Ash protein family
C1_03331	35703.DQ02_04710	7e-40	169.5	Citrobacter				ko:K07733					ko00000,ko03000				Bacteria	1NGB9@1224,1SCF2@1236,3WYZH@544,COG3311@1,COG3311@2	NA|NA|NA	K	Prophage CP4-57 regulatory protein (AlpA)
C1_03332	35703.DQ02_04720	9.2e-125	453.0	Gammaproteobacteria													Bacteria	1R99V@1224,1RNH0@1236,2C4B4@1,2Z7X9@2	NA|NA|NA	S	capsid morphogenesis protein encoded in CP-933I
C1_03333	35703.DQ02_04725	8.3e-91	339.7	Gammaproteobacteria													Bacteria	1RIRK@1224,1S7U1@1236,2DM89@1,325HM@2	NA|NA|NA	S	polarity suppression protein
C1_03334	640513.Entas_3120	3.1e-38	164.1	Gammaproteobacteria													Bacteria	1N4T2@1224,1S9YI@1236,2E32U@1,32UYH@2	NA|NA|NA	S	activator from phage origin ( Ogr family transcription activator) (NCBI YP_002381979.1)
C1_03335	1166016.W5S_1663	1.4e-169	603.2	Pectobacterium				ko:K07459					ko00000				Bacteria	1MTX2@122277,1PGA5@1224,1RWJK@1236,COG1196@1,COG1196@2,COG3593@1,COG3593@2	NA|NA|NA	L	AAA ATPase domain
C1_03336	1166016.W5S_1665	9.9e-71	274.6	Gammaproteobacteria													Bacteria	1NBQK@1224,1S0VR@1236,COG0210@1,COG0210@2	NA|NA|NA	L	helicase
C1_03337	220341.16505590	5.5e-231	806.6	Salmonella													Bacteria	1MU23@1224,1RMJ1@1236,3ZMI4@590,COG0582@1,COG0582@2	NA|NA|NA	L	Belongs to the 'phage' integrase family
C1_03339	362663.ECP_4519	1.8e-195	688.3	Escherichia	yjgB	GO:0003674,GO:0003824,GO:0004033,GO:0005488,GO:0008106,GO:0008150,GO:0008152,GO:0008270,GO:0016491,GO:0016614,GO:0016616,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0055114	1.1.1.1	ko:K12957,ko:K13953,ko:K13979	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220		R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000				Bacteria	1MUTT@1224,1RN4D@1236,3XMS3@561,COG1064@1,COG1064@2	NA|NA|NA	C	Catalyzes the reduction of a wide range of aldehydes including aliphatic fatty aldehydes (C4-C16), into their corresponding alcohols. Has a strong preference for NADPH over NADH as the electron donor. Cannot use glyceraldehyde or a ketone as substrate. Is a relevant source of NADPH-dependent aldehyde reductase activity in E.coli. The in vivo functions of Ahr has yet to be determined
C1_03340	316407.85677015	7.6e-100	369.8	Escherichia	idnK	GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019520,GO:0019521,GO:0019523,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046183,GO:0046316,GO:0046395,GO:0071704,GO:0072329,GO:1901575	2.7.1.12	ko:K00851	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200		R01737	RC00002,RC00017	ko00000,ko00001,ko01000			iECSF_1327.ECSF_4156,iUTI89_1310.UTI89_C3945	Bacteria	1RHD0@1224,1S2UE@1236,3XRI9@561,COG3265@1,COG3265@2	NA|NA|NA	F	gluconokinase activity
C1_03341	316407.85677014	2.3e-195	688.0	Gammaproteobacteria	idnD	GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019520,GO:0019523,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046183,GO:0046395,GO:0050572,GO:0055114,GO:0071704,GO:0072329,GO:1901575	1.1.1.264	ko:K00098			R05684	RC00089	ko00000,ko01000			iEcSMS35_1347.EcSMS35_4748	Bacteria	1MV9A@1224,1RPYN@1236,COG1063@1,COG1063@2	NA|NA|NA	E	L-idonate 5-dehydrogenase
C1_03342	199310.c5367	1.2e-140	505.8	Escherichia													Bacteria	1MWB6@1224,1RMZB@1236,3XQYG@561,COG1028@1,COG1028@2	NA|NA|NA	IQ	Catalyzes the reduction of 5-keto-D-gluconate to D- gluconate, using either NADH or NADPH. Is likely involved in an L- idonate degradation pathway that allows E.coli to utilize L- idonate as the sole carbon and energy source. Is also able to catalyze the reverse reaction in vitro, but the D-gluconate oxidation by the enzyme can only proceed with NAD
C1_03343	199310.c5366	6.8e-232	809.7	Escherichia	gntT	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008028,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0008643,GO:0015075,GO:0015128,GO:0015144,GO:0015171,GO:0015175,GO:0015238,GO:0015318,GO:0015568,GO:0015711,GO:0015718,GO:0015726,GO:0015804,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0022889,GO:0031224,GO:0031226,GO:0032329,GO:0034219,GO:0034220,GO:0035429,GO:0042221,GO:0042493,GO:0042873,GO:0042879,GO:0042940,GO:0042942,GO:0042943,GO:0042945,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1903825,GO:1905039		ko:K03299,ko:K06155,ko:K06157,ko:K13629,ko:K16321					ko00000,ko02000	2.A.8,2.A.8.1.2,2.A.8.1.3,2.A.8.1.4,2.A.8.1.5		iSSON_1240.SSON_3547	Bacteria	1MUFG@1224,1RNGE@1236,3XNJE@561,COG2610@1,COG2610@2	NA|NA|NA	P	gluconate transporter
C1_03344	316407.85677011	3.3e-186	657.5	Escherichia	gntR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141		ko:K06145,ko:K06146					ko00000,ko03000				Bacteria	1MUEP@1224,1RN0U@1236,3XRJ0@561,COG1609@1,COG1609@2	NA|NA|NA	K	Idn operon regulator. May repress gntKU and gntT genes when growing on L-idonate
C1_03345	1440052.EAKF1_ch1563	3e-72	277.7	Escherichia	yjgR			ko:K06915,ko:K19172					ko00000,ko02048				Bacteria	1MU59@1224,1RPYD@1236,3XP0R@561,COG0433@1,COG0433@2	NA|NA|NA	S	Type IV secretion-system coupling protein DNA-binding domain
C1_03346	155864.EDL933_5613	8.4e-193	679.5	Escherichia	yjgR			ko:K06915,ko:K19172					ko00000,ko02048				Bacteria	1MU59@1224,1RPYD@1236,3XP0R@561,COG0433@1,COG0433@2	NA|NA|NA	S	Type IV secretion-system coupling protein DNA-binding domain
C1_03347	155864.EDL933_5612	4.2e-195	687.2	Escherichia	lptG	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015920,GO:0016020,GO:0016021,GO:0031224,GO:0032991,GO:0033036,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1902494,GO:1902495,GO:1904949,GO:1990351		ko:K11720	ko02010,map02010	M00320			ko00000,ko00001,ko00002,ko02000	1.B.42.1		iSSON_1240.SSON_4447	Bacteria	1MVW3@1224,1RM8H@1236,3XP68@561,COG0795@1,COG0795@2	NA|NA|NA	S	Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane
C1_03348	198214.SF4228	1.2e-194	685.6	Gammaproteobacteria	lptF	GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015399,GO:0015405,GO:0015437,GO:0015920,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0032991,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351		ko:K07091,ko:K11720	ko02010,map02010	M00320			ko00000,ko00001,ko00002,ko02000	1.B.42.1		iECED1_1282.ECED1_5114,iUMNK88_1353.UMNK88_5207	Bacteria	1MUF2@1224,1RMN5@1236,COG0795@1,COG0795@2	NA|NA|NA	S	Permease
C1_03349	155864.EDL933_5609	4.5e-288	996.5	Escherichia	pepA	GO:0001073,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006351,GO:0006355,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009056,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016787,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019538,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042150,GO:0043170,GO:0043171,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043244,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0097718,GO:0140096,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1903506,GO:2000112,GO:2001141	3.4.11.1,3.4.11.23	ko:K01255,ko:K07751	ko00480,ko01100,map00480,map01100		R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002			iAF1260.b2523,iBWG_1329.BWG_2287,iECDH10B_1368.ECDH10B_2690,iECDH1ME8569_1439.ECDH1ME8569_2450,iEcDH1_1363.EcDH1_1145,iJO1366.b2523,iY75_1357.Y75_RS13170	Bacteria	1MUF9@1224,1RNM1@1236,3XNPE@561,COG0260@1,COG0260@2	NA|NA|NA	E	involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C1_03350	1440052.EAKF1_ch1569	4.5e-85	320.5	Escherichia	holC	GO:0005575,GO:0005622,GO:0005623,GO:0006275,GO:0008150,GO:0009314,GO:0009360,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010556,GO:0010557,GO:0010604,GO:0019219,GO:0019222,GO:0030174,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032298,GO:0032991,GO:0042575,GO:0043846,GO:0043847,GO:0044424,GO:0044464,GO:0045740,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051171,GO:0051173,GO:0060255,GO:0061695,GO:0065007,GO:0080090,GO:0090329,GO:1902494,GO:1990234,GO:2000105,GO:2000112	2.7.7.7	ko:K02339	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Bacteria	1MZ3V@1224,1S94K@1236,3XN75@561,COG2927@1,COG2927@2	NA|NA|NA	L	Part of the beta sliding clamp loading complex, which hydrolyzes ATP to load the beta clamp onto primed DNA to form the DNA replication pre-initiation complex. DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C1_03351	316407.85677005	0.0	1914.0	Escherichia	valS	GO:0000287,GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006438,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045903,GO:0046483,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0052689,GO:0060255,GO:0061475,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:2000112	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iECH74115_1262.ECH74115_5779,iECNA114_1301.ECNA114_4481,iECO26_1355.ECO26_5428,iECSP_1301.ECSP_5359,iECs_1301.ECs5235,iG2583_1286.G2583_5088,iJN746.PP_0977,iSBO_1134.SBO_4182,iSSON_1240.SSON_4443,iYL1228.KPN_04663,iZ_1308.Z5870	Bacteria	1MV7B@1224,1RNEB@1236,3XMYC@561,COG0525@1,COG0525@2	NA|NA|NA	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
C1_03352	198214.SF4232	7.3e-217	759.6	Gammaproteobacteria	yjgN	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1MW5P@1224,1RY3G@1236,COG4269@1,COG4269@2	NA|NA|NA	S	Membrane
C1_03353	316407.85677003	1.2e-91	342.4	Escherichia	yjgM			ko:K03828					ko00000,ko01000				Bacteria	1RAJC@1224,1S1YW@1236,3XRN5@561,COG0454@1,COG0456@2	NA|NA|NA	K	transferase activity, transferring acyl groups
C1_03354	155864.EDL933_5604	1e-69	269.2	Escherichia	rraB	GO:0003674,GO:0004857,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008428,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0019219,GO:0019222,GO:0019439,GO:0019899,GO:0030234,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0034641,GO:0034655,GO:0043086,GO:0043170,GO:0044092,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046483,GO:0046700,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060698,GO:0060699,GO:0060700,GO:0060701,GO:0060702,GO:0065007,GO:0065009,GO:0071704,GO:0080090,GO:0090304,GO:0098772,GO:1901360,GO:1901361,GO:1901575		ko:K09893					ko00000,ko03019				Bacteria	1RDKS@1224,1S4A6@1236,3XPME@561,COG3076@1,COG3076@2	NA|NA|NA	S	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
C1_03355	198214.SF4235	7.8e-188	662.9	Gammaproteobacteria	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000			iECS88_1305.ECS88_4841,iHN637.CLJU_RS12430	Bacteria	1MUFM@1224,1RQ59@1236,COG0078@1,COG0078@2	NA|NA|NA	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C1_03356	469008.B21_04083	1.6e-283	981.5	Escherichia	yjgL												Bacteria	1QIG4@1224,1TGAH@1236,2AUX4@1,31KKI@2,3XQ8V@561	NA|NA|NA		
C1_03357	198214.SF4239	1.7e-81	308.5	Gammaproteobacteria	tabA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009987,GO:0042710,GO:0044010,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0051704		ko:K12112,ko:K19334	ko00052,ko00511,ko01100,map00052,map00511,map01100		R01678	RC00049	ko00000,ko00001,ko02048				Bacteria	1RA6C@1224,1S281@1236,COG2731@1,COG2731@2	NA|NA|NA	G	Toxin-antitoxin biofilm protein TabA
C1_03358	316407.85676998	3.7e-105	387.5	Gammaproteobacteria	yjgJ	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010038,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042221,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046688,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K16137,ko:K19335,ko:K22041					ko00000,ko03000				Bacteria	1RC4X@1224,1S20B@1236,COG1309@1,COG1309@2	NA|NA|NA	K	tetR family
C1_03359	155864.EDL933_5599	1.3e-125	455.7	Escherichia													Bacteria	1N4J7@1224,1RQ0S@1236,3XRI8@561,COG1028@1,COG1028@2	NA|NA|NA	IQ	Increases biofilm dispersal. Acts by binding directly to the signaling molecule cyclic-di-GMP, which decreases the intracellular concentration of cyclic-di-GMP and leads to biofilm dispersal. Also controls other biofilm-related phenotypes such as cell motility, cell size, cell aggregation and production of extracellular DNA and extracellular polysaccharides (EPS). Does not act as a phosphodiesterase
C1_03360	469008.B21_04079	2e-70	271.6	Escherichia	yjgH												Bacteria	1RCX5@1224,1S478@1236,3XPQT@561,COG0251@1,COG0251@2	NA|NA|NA	J	Endoribonuclease L-PSP
C1_03361	155864.EDL933_5595	1.5e-172	612.1	Escherichia	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000			iZ_1308.Z5856	Bacteria	1MWAB@1224,1RPSV@1236,3XMRZ@561,COG0540@1,COG0540@2	NA|NA|NA	F	Belongs to the ATCase OTCase family
C1_03362	155864.EDL933_5594	2.9e-81	307.8	Escherichia	pyrI	GO:0003674,GO:0003824,GO:0004070,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00608,ko:K00610	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000				Bacteria	1RB7J@1224,1S2BM@1236,3XNQ2@561,COG1781@1,COG1781@2	NA|NA|NA	F	Involved in allosteric regulation of aspartate carbamoyltransferase
C1_03363	155864.EDL933_5593	2.3e-63	248.1	Escherichia	ridA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009636,GO:0016787,GO:0019239,GO:0042221,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051082	3.5.99.10	ko:K09022			R11098,R11099	RC03275,RC03354	ko00000,ko01000				Bacteria	1MZ3J@1224,1S5XS@1236,3XPKX@561,COG0251@1,COG0251@2	NA|NA|NA	J	Accelerates the release of ammonia from reactive enamine imine intermediates of the PLP-dependent threonine dehydratase (IlvA) in the low water environment of the cell. It catalyzes the deamination of enamine imine intermediates to yield 2-ketobutyrate and ammonia. It is required for the detoxification of reactive intermediates of IlvA due to their highly nucleophilic abilities. Involved in the isoleucine biosynthesis (By similarity)
C1_03364	481805.EcolC_3769	0.0	1757.7	Escherichia	mgtA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015318,GO:0015399,GO:0015405,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0099131,GO:0099132	3.6.3.2	ko:K01531,ko:K16905	ko02010,map02010	M00224			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.3.4		iSF_1195.SF4248	Bacteria	1MUU5@1224,1RMYC@1236,3XNGR@561,COG0474@1,COG0474@2	NA|NA|NA	P	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily
C1_03365	199310.c5340	1.6e-174	618.6	Escherichia	treR	GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K03485					ko00000,ko03000				Bacteria	1QQPR@1224,1RRC9@1236,3XN38@561,COG1609@1,COG1609@2	NA|NA|NA	K	repressor
C1_03366	155864.EDL933_5590	7.2e-264	916.0	Escherichia	treB	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0015766,GO:0015771,GO:0015772,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090589	2.7.1.192,2.7.1.193,2.7.1.199,2.7.1.201,2.7.1.208	ko:K02749,ko:K02750,ko:K02752,ko:K02753,ko:K02778,ko:K02779,ko:K02790,ko:K02791,ko:K02802,ko:K02803,ko:K02804,ko:K02817,ko:K02818,ko:K02819,ko:K11191,ko:K11192	ko00010,ko00500,ko00520,ko02060,ko05111,map00010,map00500,map00520,map02060,map05111	M00265,M00266,M00267,M00268,M00270,M00272,M00303	R02738,R02780,R04111,R04394,R05132,R05199,R08559	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.1.1,4.A.1.1.10,4.A.1.1.15,4.A.1.1.16,4.A.1.1.2,4.A.1.1.3,4.A.1.1.4,4.A.1.1.5,4.A.1.1.7,4.A.1.1.8,4.A.1.2.13,4.A.1.2.3,4.A.1.2.4,4.A.1.2.7,4.A.1.2.8		iECABU_c1320.ECABU_c48060,iECIAI39_1322.ECIAI39_2574,iECIAI39_1322.ECIAI39_2901,iECNA114_1301.ECNA114_1668,iECP_1309.ECP_0691,iECSF_1327.ECSF_1482,ic_1306.c5339	Bacteria	1MVVJ@1224,1RMYB@1236,3XM3T@561,COG1263@1,COG1263@2,COG1264@1,COG1264@2	NA|NA|NA	G	PTS system, trehalose-specific
C1_03367	199310.c5338	0.0	1162.9	Escherichia	treC	GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005991,GO:0005993,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008788,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0015927,GO:0016052,GO:0016787,GO:0016798,GO:0033554,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046352,GO:0050896,GO:0051716,GO:0071704,GO:1901575	3.2.1.93	ko:K01226	ko00500,map00500		R00837,R06113	RC00049	ko00000,ko00001,ko01000		GH13	iECW_1372.ECW_m4600,iEKO11_1354.EKO11_4072,iEcE24377_1341.EcE24377A_4811,iEcSMS35_1347.EcSMS35_4720,iWFL_1372.ECW_m4600	Bacteria	1MVKX@1224,1RMSH@1236,3XMPX@561,COG0366@1,COG0366@2	NA|NA|NA	G	Hydrolyzes trehalose-6-phosphate to glucose and glucose 6-phosphate. Can also very effectively hydrolyzes p-nitrophenyl- alpha-D-glucopyranoside, but it does not recognize trehalose, sucrose, maltose, isomaltose, or maltodextrins
C1_03368	316407.85676987	0.0	1453.0	Escherichia	nrdD	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0008998,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0015949,GO:0016491,GO:0016725,GO:0016728,GO:0017076,GO:0018130,GO:0019001,GO:0019103,GO:0019438,GO:0019637,GO:0019692,GO:0030554,GO:0031250,GO:0032552,GO:0032553,GO:0032554,GO:0032555,GO:0032556,GO:0032558,GO:0032559,GO:0032560,GO:0032564,GO:0032567,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046385,GO:0046483,GO:0046872,GO:0046914,GO:0051065,GO:0055086,GO:0055114,GO:0071704,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000			iECIAI39_1322.ECIAI39_4713,iPC815.YPO3454	Bacteria	1MWMS@1224,1RNHS@1236,3XP9C@561,COG1328@1,COG1328@2	NA|NA|NA	F	anaerobic ribonucleoside-triphosphate reductase
C1_03369	155864.EDL933_5584	8.5e-89	332.8	Escherichia	nrdG	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008998,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0015949,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0019692,GO:0031250,GO:0032991,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046385,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901576	1.97.1.4	ko:K04068			R04710		ko00000,ko01000			iE2348C_1286.E2348C_4563	Bacteria	1RA7S@1224,1S20X@1236,3XNWN@561,COG0602@1,COG0602@2	NA|NA|NA	O	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C1_03370	634499.EpC_31640	8.1e-29	132.9	Erwinia	relE			ko:K06218					ko00000,ko02048				Bacteria	1MZ76@1224,1S8RR@1236,3X7Y9@551,COG2026@1,COG2026@2	NA|NA|NA	DJ	silverDB
C1_03371	754331.AEME01000001_gene3410	3.7e-35	153.7	Escherichia	relB			ko:K07473,ko:K18918					ko00000,ko02048,ko03000				Bacteria	1N8G2@1224,1SCQI@1236,3XREU@561,COG3077@1,COG3077@2	NA|NA|NA	K	Antitoxin component of a type II toxin-antitoxin (TA) system. Counteracts the effect of cognate toxin RelE via direct protein-protein interaction, preventing RelE from entering the ribosome A site and thus inhibiting its endoribonuclease activity. An autorepressor of relBE operon transcription. 2 RelB dimers bind to 2 operator sequences
C1_03372	199310.c5335	1.1e-60	239.2	Escherichia	cybC			ko:K15536					ko00000				Bacteria	1N1DX@1224,1SAB6@1236,3XPIN@561,COG3783@1,COG3783@2	NA|NA|NA	C	Soluble cytochrome b562
C1_03373	155864.EDL933_5582	1.2e-252	878.6	Escherichia	pmbA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564		ko:K03592					ko00000,ko01002				Bacteria	1MUVW@1224,1RPJF@1236,3XMDW@561,COG0312@1,COG0312@2	NA|NA|NA	S	Metalloprotease involved in CcdA degradation. Suppresses the inhibitory activity of the carbon storage regulator (CsrA)
C1_03374	155864.EDL933_5581	3.6e-94	350.9	Escherichia	yjgA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K09889					ko00000,ko03009				Bacteria	1MZ4R@1224,1S9JJ@1236,3XN2N@561,COG3028@1,COG3028@2	NA|NA|NA	S	UPF0307 protein YjgA
C1_03375	155864.EDL933_5580	1.7e-270	937.9	Escherichia	murC	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0016874,GO:0016879,GO:0016881,GO:0042802,GO:0044424,GO:0044464	6.3.2.4,6.3.2.45,6.3.2.8	ko:K01921,ko:K01924,ko:K02558	ko00471,ko00473,ko00550,ko01100,ko01502,map00471,map00473,map00550,map01100,map01502		R01150,R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011			iECP_1309.ECP_0093,iSDY_1059.SDY_4251	Bacteria	1MUC5@1224,1RMMT@1236,3XNY8@561,COG0773@1,COG0773@2	NA|NA|NA	M	Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate
C1_03376	198214.SF4258	2.8e-190	671.0	Gammaproteobacteria	fbp	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005985,GO:0005986,GO:0005996,GO:0006000,GO:0006002,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016043,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0022607,GO:0030388,GO:0034637,GO:0042132,GO:0042578,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046364,GO:0050308,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901135,GO:1901576	3.1.3.11	ko:K03841	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910	M00003,M00165,M00167,M00344	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000,ko04147			iUTI89_1310.UTI89_C4836,ic_1306.c5329	Bacteria	1MW0E@1224,1RNFF@1236,COG0158@1,COG0158@2	NA|NA|NA	G	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C1_03377	469008.B21_04063	1.7e-174	618.6	Escherichia	yjfF	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K02057		M00221			ko00000,ko00002,ko02000	3.A.1.2		iECW_1372.ECW_m4592,iEKO11_1354.EKO11_4080,iWFL_1372.ECW_m4592	Bacteria	1MW9Z@1224,1RQ77@1236,3XMEW@561,COG1172@1,COG1172@2	NA|NA|NA	G	ABC transporter permease protein YjfF
C1_03378	469008.B21_04062	8.5e-174	616.3	Escherichia	ytfT	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015146,GO:0015591,GO:0015749,GO:0015750,GO:0015752,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0032991,GO:0034219,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351		ko:K02057		M00221			ko00000,ko00002,ko02000	3.A.1.2		iAPECO1_1312.APECO1_2162,iECH74115_1262.ECH74115_5749,iECOK1_1307.ECOK1_4745,iECSF_1327.ECSF_4119,iLF82_1304.LF82_3716,iUTI89_1310.UTI89_C4834,ic_1306.c5327	Bacteria	1MUM6@1224,1RRCX@1236,3XMG1@561,COG1172@1,COG1172@2	NA|NA|NA	G	Belongs to the binding-protein-dependent transport system permease family
C1_03379	199310.c5326	1.2e-272	945.3	Escherichia	ytfR		3.6.3.17	ko:K02056		M00221			ko00000,ko00002,ko01000,ko02000	3.A.1.2		iECED1_1282.ECED1_5085	Bacteria	1MU22@1224,1RMCH@1236,3XMNV@561,COG1129@1,COG1129@2	NA|NA|NA	P	ABC transporter, ATP-binding protein
C1_03380	362663.ECP_4477	7.5e-172	609.8	Escherichia	ytfQ	GO:0003674,GO:0005215,GO:0005488,GO:0005534,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0008645,GO:0015144,GO:0015145,GO:0015749,GO:0015757,GO:0016020,GO:0016021,GO:0022857,GO:0030246,GO:0030288,GO:0030313,GO:0031224,GO:0031975,GO:0034219,GO:0036094,GO:0042597,GO:0044425,GO:0044464,GO:0048029,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944		ko:K02058		M00221			ko00000,ko00002,ko02000	3.A.1.2		iECH74115_1262.ECH74115_5745,iECSP_1301.ECSP_5328,iECs_1301.ECs5205,iG2583_1286.G2583_5057,iSSON_1240.SSON_4409,iZ_1308.Z5838	Bacteria	1MXJS@1224,1RRZV@1236,3XNEE@561,COG1879@1,COG1879@2	NA|NA|NA	G	galactose binding
C1_03381	155864.EDL933_5573	7.4e-97	359.8	Escherichia	ppa	GO:0000287,GO:0003674,GO:0003824,GO:0004427,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006793,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050355	3.6.1.1	ko:K01507	ko00190,map00190				ko00000,ko00001,ko01000			iPC815.YPO3521	Bacteria	1RA2F@1224,1RPVD@1236,3XM55@561,COG0221@1,COG0221@2	NA|NA|NA	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C1_03382	155864.EDL933_5572	2.2e-48	198.0	Gammaproteobacteria	chpB	GO:0001558,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009894,GO:0009987,GO:0010468,GO:0010608,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019219,GO:0019222,GO:0030308,GO:0031323,GO:0031329,GO:0034641,GO:0040008,GO:0043170,GO:0043487,GO:0043488,GO:0044237,GO:0044238,GO:0045926,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0061013,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1903311		ko:K07171,ko:K18841					ko00000,ko01000,ko02048				Bacteria	1RH4Z@1224,1S4NQ@1236,COG2337@1,COG2337@2	NA|NA|NA	T	Toxic component of a toxin-antitoxin (TA) module
C1_03383	316407.85676975	1.7e-38	164.9	Gammaproteobacteria	chpS	GO:0001558,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0030307,GO:0032991,GO:0040008,GO:0042802,GO:0042803,GO:0043933,GO:0044085,GO:0044877,GO:0045927,GO:0046983,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051259,GO:0051291,GO:0065003,GO:0065007,GO:0071840,GO:0097159,GO:0097351,GO:1901363		ko:K07172,ko:K18842					ko00000,ko02048				Bacteria	1NHRR@1224,1SFWR@1236,COG2336@1,COG2336@2	NA|NA|NA	K	Antitoxin component of a type II toxin-antitoxin (TA) system. May be involved in the regulation of cell growth. It acts as a suppressor of the endoribonuclease (inhibitory function) of ChpB protein. Both ChpS and ChpB probably bind to the promoter region of the chpS-chpB operon to autoregulate their synthesis
C1_03384	198214.SF4265	8.5e-62	242.7	Gammaproteobacteria	ytfP	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Bacteria	1RH3X@1224,1S68T@1236,COG2105@1,COG2105@2	NA|NA|NA	S	AIG2 family
C1_03385	316407.85676972	0.0	2463.0	Escherichia	ytfN	GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032940,GO:0032991,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0097347		ko:K09800					ko00000,ko02000				Bacteria	1MUVD@1224,1RMMF@1236,3XPEG@561,COG2911@1,COG2911@2	NA|NA|NA	S	Part of the translocation and assembly module (TAM) autotransporter assembly complex, which functions in translocation of autotransporters across the outer membrane. In reconstituted TAM this subunit (Ag43, AC P39180) is not necessary for substrate penetration in the outer membrane. Substrate binding to TamA moves its POTRA domains about 30 Angstroms into the periplasm, which would deform either the outer membrane or TamB and may provide force to reset TAM
C1_03386	155864.EDL933_5568	0.0	1172.5	Escherichia	ytfM	GO:0002790,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0009279,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0019867,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031975,GO:0032940,GO:0032991,GO:0033036,GO:0042886,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045203,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0097347		ko:K07278					ko00000,ko02000	1.B.33.2.4			Bacteria	1MUKM@1224,1RNQ3@1236,3XMQX@561,COG0729@1,COG0729@2	NA|NA|NA	M	Part of the translocation and assembly module (TAM) autotransporter assembly complex, which functions in translocation of autotransporters across the outer membrane
C1_03387	198214.SF4268	1.1e-123	449.1	Gammaproteobacteria	msrA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006807,GO:0006950,GO:0006979,GO:0008113,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016667,GO:0016671,GO:0019538,GO:0030091,GO:0033744,GO:0036456,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0055114,GO:0071704,GO:1901564	1.8.4.11	ko:K07304					ko00000,ko01000			iECSE_1348.ECSE_4525	Bacteria	1MVUS@1224,1RNWU@1236,COG0225@1,COG0225@2	NA|NA|NA	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1_03388	155864.EDL933_5564	1.3e-230	805.4	Escherichia	ytfL	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03699					ko00000,ko02042				Bacteria	1MV3P@1224,1T1MS@1236,3XNSD@561,COG1253@1,COG1253@2	NA|NA|NA	P	inner membrane protein YtfL
C1_03389	155864.EDL933_5563	4e-30	136.7	Escherichia	ytfK												Bacteria	1MZ8V@1224,1S908@1236,2CTIP@1,32STK@2,3XQ29@561	NA|NA|NA	S	Protein of unknown function (DUF1107)
C1_03390	155864.EDL933_5562	6e-97	360.1	Escherichia	ytfJ			ko:K07109					ko00000				Bacteria	1REC3@1224,1S3X5@1236,3XP2K@561,COG3054@1,COG3054@2	NA|NA|NA	S	Bacterial protein of unknown function (YtfJ_HI0045)
C1_03391	155864.EDL933_5561	9.3e-164	582.8	Gammaproteobacteria	ytfI												Bacteria	1NS1T@1224,1SJTN@1236,2EYVH@1,33S2K@2	NA|NA|NA		
C1_03392	199310.c5313	2.8e-142	511.1	Escherichia	cysQ	GO:0000103,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006790,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008252,GO:0008441,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872	3.1.3.7	ko:K01082	ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130		R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03016			iAPECO1_1312.APECO1_2172,iE2348C_1286.E2348C_4545,iEC042_1314.EC042_4695,iEC55989_1330.EC55989_4774,iECABU_c1320.ECABU_c47840,iECIAI1_1343.ECIAI1_4448,iECIAI39_1322.ECIAI39_4686,iECO103_1326.ECO103_5013,iECO111_1330.ECO111_5101,iECO26_1355.ECO26_5384,iECOK1_1307.ECOK1_4735,iECP_1309.ECP_4468,iECSE_1348.ECSE_4520,iECSF_1327.ECSF_4108,iECUMN_1333.ECUMN_4751,iECW_1372.ECW_m4578,iEKO11_1354.EKO11_4094,iEcE24377_1341.EcE24377A_4785,iEcHS_1320.EcHS_A4468,iEcSMS35_1347.EcSMS35_4694,iLF82_1304.LF82_0422,iNRG857_1313.NRG857_21455,iSBO_1134.SBO_4229,iSDY_1059.SDY_4385,iSSON_1240.SSON_4399,iSbBS512_1146.SbBS512_E4758,iUMN146_1321.UM146_21355,iUTI89_1310.UTI89_C4823,iWFL_1372.ECW_m4578,ic_1306.c5313	Bacteria	1N0GY@1224,1RP5A@1236,3XNJQ@561,COG1218@1,COG1218@2	NA|NA|NA	P	Belongs to the inositol monophosphatase superfamily. CysQ family
C1_03393	316407.85676964	0.0	1293.9	Escherichia	cpdB	GO:0003674,GO:0003824,GO:0004112,GO:0005575,GO:0005623,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0008252,GO:0008254,GO:0008663,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0030288,GO:0030313,GO:0031975,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0042597,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.1.3.5,3.1.3.6,3.1.4.16	ko:K01119,ko:K08693	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110		R00183,R00511,R00963,R01126,R01227,R01562,R01569,R01664,R01877,R01968,R02088,R02102,R02148,R02370,R02719,R03537,R03538,R03929,R05135	RC00017,RC00078,RC00296	ko00000,ko00001,ko01000			iEC55989_1330.EC55989_4773,iECH74115_1262.ECH74115_5730,iECNA114_1301.ECNA114_4436,iECSP_1301.ECSP_5315,iECW_1372.ECW_m4577,iECs_1301.ECs5191,iEKO11_1354.EKO11_4095,iEcE24377_1341.EcE24377A_4783,iG2583_1286.G2583_5043,iWFL_1372.ECW_m4577,iYO844.BSU07840,iZ_1308.Z5824	Bacteria	1MU11@1224,1RMQV@1236,3XNBH@561,COG0737@1,COG0737@2	NA|NA|NA	F	Belongs to the 5'-nucleotidase family
C1_03394	199310.c5311	1e-63	249.2	Escherichia	ytfH												Bacteria	1MZ6N@1224,1S5WB@1236,3XPSJ@561,COG1733@1,COG1733@2	NA|NA|NA	K	nucleic acid-templated transcription
C1_03395	34506.g1061	2.2e-146	525.0	Metazoa													Metazoa	2S5T1@2759,3A6NA@33154,3CNSA@33208,COG0702@1	NA|NA|NA	GM	NmrA-like family
C1_03396	155864.EDL933_5556	1.8e-178	631.7	Escherichia	ytfF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1MW7P@1224,1RQ9F@1236,3XMIQ@561,COG0697@1,COG0697@2	NA|NA|NA	EG	EamA-like transporter family
C1_03397	198214.SF4277	1.4e-121	442.2	Gammaproteobacteria	ytfE	GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0018282,GO:0018283,GO:0019538,GO:0022607,GO:0030091,GO:0031163,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0071704,GO:0071840,GO:1901564		ko:K07322					ko00000			iECED1_1282.ECED1_5068,iECH74115_1262.ECH74115_5726,iECSP_1301.ECSP_5311,iECs_1301.ECs5187,iG2583_1286.G2583_5039,iZ_1308.Z5820	Bacteria	1MVCQ@1224,1RPY6@1236,COG2846@1,COG2846@2	NA|NA|NA	D	Di-iron-containing protein involved in the repair of iron-sulfur clusters
C1_03398	155864.EDL933_5554	1.1e-256	892.1	Escherichia	cycA	GO:0001761,GO:0001762,GO:0003333,GO:0003674,GO:0005215,GO:0005326,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015175,GO:0015179,GO:0015180,GO:0015187,GO:0015238,GO:0015318,GO:0015711,GO:0015804,GO:0015807,GO:0015808,GO:0015816,GO:0015849,GO:0015893,GO:0016020,GO:0022857,GO:0022858,GO:0022889,GO:0032328,GO:0032329,GO:0034220,GO:0042221,GO:0042493,GO:0042891,GO:0042895,GO:0042940,GO:0042941,GO:0042942,GO:0042943,GO:0042944,GO:0042945,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903825,GO:1905039		ko:K03293,ko:K11737					ko00000,ko02000	2.A.3.1,2.A.3.1.7		iECO111_1330.ECO111_5093,iECO26_1355.ECO26_5376,iEcHS_1320.EcHS_A4458,iSbBS512_1146.SbBS512_E4749,iYL1228.KPN_04601	Bacteria	1MUPS@1224,1RPFT@1236,3XMYN@561,COG1113@1,COG1113@2	NA|NA|NA	E	Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine
C1_03399	155864.EDL933_5553	1.8e-110	405.2	Escherichia	fklB	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005515,GO:0005527,GO:0005528,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0042597,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097159,GO:0140096,GO:1901363,GO:1901564	5.2.1.8	ko:K03773					ko00000,ko01000,ko03110				Bacteria	1RDA1@1224,1RPMP@1236,3XMCG@561,COG0545@1,COG0545@2	NA|NA|NA	O	peptidyl-prolyl cis-trans isomerase
C1_03400	316407.85676957	6.6e-116	423.3	Escherichia	ytfB			ko:K07268,ko:K07269					ko00000				Bacteria	1R4XK@1224,1S430@1236,3XPK0@561,COG3061@1,COG3061@2	NA|NA|NA	M	Opacity-associated protein A N-terminal motif
C1_03401	316407.85676956	6.9e-53	213.0	Escherichia	ytfA			ko:K09017					ko00000,ko03000				Bacteria	1R5AI@1224,1S6BI@1236,3XPXB@561,COG1309@1,COG1309@2	NA|NA|NA	K	Bacterial regulatory proteins, tetR family
C1_03402	511145.b4204	6.7e-150	536.6	Escherichia													Bacteria	1NQYJ@1224,1SM8F@1236,2F0KM@1,33TP9@2,3XQXP@561	NA|NA|NA	S	Protein of unknown function (DUF2686)
C1_03403	1440052.EAKF1_ch1626c	5.9e-71	273.5	Escherichia	rplI	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02939	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1RD0R@1224,1S3WS@1236,3XMY6@561,COG0359@1,COG0359@2	NA|NA|NA	J	Binds to the 23S rRNA
C1_03404	1005994.GTGU_02012	1.1e-33	148.7	Gammaproteobacteria	rpsR	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048027,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02963	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1MZ8U@1224,1S8R8@1236,COG0238@1,COG0238@2	NA|NA|NA	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C1_03405	362663.ECP_4446	1.3e-53	215.3	Escherichia	priB	GO:0000228,GO:0000428,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005657,GO:0005658,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006270,GO:0006276,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0016070,GO:0018130,GO:0019438,GO:0030880,GO:0030894,GO:0031974,GO:0031981,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043565,GO:0043596,GO:0043601,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0046483,GO:0050896,GO:0055029,GO:0061695,GO:0070013,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990077,GO:1990099,GO:1990234,GO:1990837		ko:K02686	ko03440,map03440				ko00000,ko00001,ko03400				Bacteria	1RHIE@1224,1S6H5@1236,3XPXW@561,COG2965@1,COG2965@2	NA|NA|NA	L	Binds single-stranded DNA at the primosome assembly site (PAS). During primosome assembly it facilitates the complex formation between PriA and DnaT
C1_03406	1440052.EAKF1_ch1628c	3e-66	257.7	Escherichia	rpsF	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048027,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	4.3.1.19	ko:K01754,ko:K02990	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,ko03010,map00260,map00290,map01100,map01110,map01130,map01200,map01230,map03010	M00178,M00570	R00220,R00996	RC00418,RC02600	br01610,ko00000,ko00001,ko00002,ko01000,ko03011,ko03029				Bacteria	1RH82@1224,1S5VU@1236,3XPK6@561,COG0360@1,COG0360@2	NA|NA|NA	J	Binds together with S18 to 16S ribosomal RNA
C1_03407	155864.EDL933_5544	1.2e-42	178.7	Escherichia	yjfY												Bacteria	1N0ER@1224,1SA4Y@1236,2CSU0@1,32SRX@2,3XQ14@561	NA|NA|NA	S	Protein of unknown function (DUF1471)
C1_03408	316407.85676949	3.3e-129	467.6	Escherichia	ulaF	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006004,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008738,GO:0008742,GO:0008994,GO:0009056,GO:0009058,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0016853,GO:0016854,GO:0016857,GO:0019299,GO:0019301,GO:0019317,GO:0019318,GO:0019320,GO:0019321,GO:0019323,GO:0019324,GO:0019566,GO:0019568,GO:0019569,GO:0019571,GO:0019572,GO:0019637,GO:0019752,GO:0019852,GO:0042354,GO:0042355,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046372,GO:0046373,GO:0046872,GO:0046914,GO:0051167,GO:0051186,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901159,GO:1901575,GO:1901576	4.1.1.104,4.1.2.17,4.1.2.19,5.1.3.4	ko:K01628,ko:K01629,ko:K03077,ko:K22130	ko00040,ko00051,ko00053,ko01100,ko01120,map00040,map00051,map00053,map01100,map01120	M00550	R01785,R02262,R02263,R05850	RC00438,RC00599,RC00603,RC00604,RC01479	ko00000,ko00001,ko00002,ko01000			iECED1_1282.ECED1_3191,iECO111_1330.ECO111_4403,iLF82_1304.LF82_1866,iNRG857_1313.NRG857_19475,iSDY_1059.SDY_4367,iSSON_1240.SSON_0067	Bacteria	1MU54@1224,1RMIP@1236,3XM68@561,COG0235@1,COG0235@2	NA|NA|NA	G	Catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate. Is involved in the anaerobic L-ascorbate utilization
C1_03409	199310.c5287	2e-160	571.6	Escherichia	ulaE	GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016854,GO:0016857,GO:0019752,GO:0019852,GO:0034015,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0051186,GO:0071704	5.1.3.22	ko:K03079	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R03244	RC00540	ko00000,ko00001,ko00002,ko01000			iEC55989_1330.EC55989_4754,iECSE_1348.ECSE_4495,iEcHS_1320.EcHS_A4441,iEcSMS35_1347.EcSMS35_4668,iYL1228.KPN_04590	Bacteria	1MWTD@1224,1RPT6@1236,3XNDK@561,COG3623@1,COG3623@2	NA|NA|NA	G	Catalyzes the isomerization of L-xylulose-5-phosphate to L-ribulose-5-phosphate. Is involved in the anaerobic L-ascorbate utilization
C1_03410	155864.EDL933_5541	1.4e-118	432.2	Escherichia	ulaD	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0005996,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0008150,GO:0008152,GO:0009056,GO:0009109,GO:0009111,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0019852,GO:0019854,GO:0033982,GO:0042365,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046365,GO:0046395,GO:0046872,GO:0051186,GO:0051187,GO:0071704,GO:1901575	4.1.1.85,4.1.2.43	ko:K03078,ko:K08093	ko00030,ko00040,ko00053,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00040,map00053,map00680,map01100,map01120,map01200,map01230	M00345,M00550,M00580	R05338,R07125	RC00421,RC00422,RC01721	ko00000,ko00001,ko00002,ko01000			iAF1260.b4196,iAPECO1_1312.APECO1_2196,iBWG_1329.BWG_3908,iE2348C_1286.E2348C_4519,iECDH10B_1368.ECDH10B_4391,iECDH1ME8569_1439.ECDH1ME8569_4053,iECED1_1282.ECED1_4983,iECIAI1_1343.ECIAI1_4429,iECNA114_1301.ECNA114_4412,iECOK1_1307.ECOK1_4710,iECP_1309.ECP_4441,iECS88_1305.ECS88_4782,iECSE_1348.ECSE_4494,iECSF_1327.ECSF_4082,iEcDH1_1363.EcDH1_3797,iJO1366.b4196,iJR904.b4196,iLF82_1304.LF82_2375,iNRG857_1313.NRG857_21325,iUMN146_1321.UM146_21220,iY75_1357.Y75_RS21850	Bacteria	1QWE4@1224,1RPV5@1236,3XM54@561,COG0269@1,COG0269@2	NA|NA|NA	F	Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. Is involved in the anaerobic L-ascorbate utilization
C1_03411	469008.B21_04024	3.8e-81	307.4	Escherichia	ulaC	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0015711,GO:0015749,GO:0015849,GO:0015882,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0034220,GO:0035461,GO:0044464,GO:0046942,GO:0051179,GO:0051180,GO:0051181,GO:0051182,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090585,GO:0098656,GO:1903825,GO:1905039	2.7.1.194,2.7.1.195,2.7.1.197,2.7.1.200,2.7.1.202,2.7.3.9	ko:K02768,ko:K02769,ko:K02770,ko:K02773,ko:K02798,ko:K02806,ko:K02821,ko:K08483,ko:K11189,ko:K11198,ko:K11199,ko:K11200,ko:K11201,ko:K18531	ko00051,ko00052,ko00053,ko01100,ko01120,ko02060,map00051,map00052,map00053,map01100,map01120,map02060	M00273,M00274,M00279,M00283,M00305,M00306,M00550	R02704,R03232,R05570,R07671,R11169	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1,4.A.2.1.12,4.A.2.1.2,4.A.2.1.24,4.A.2.1.3,4.A.2.1.5,4.A.5.1,4.A.7.1,8.A.7		iAF1260.b4195,iBWG_1329.BWG_3907,iECABU_c1320.ECABU_c47530,iECDH10B_1368.ECDH10B_4390,iECDH1ME8569_1439.ECDH1ME8569_4052,iECH74115_1262.ECH74115_5711,iECIAI39_1322.ECIAI39_0923,iECSP_1301.ECSP_5295,iECUMN_1333.ECUMN_4728,iECs_1301.ECs5171,iEcDH1_1363.EcDH1_3798,iEcSMS35_1347.EcSMS35_4666,iG2583_1286.G2583_5022,iJO1366.b4195,iSbBS512_1146.SbBS512_E4725,iY75_1357.Y75_RS21845,iZ_1308.Z5804,ic_1306.c5284	Bacteria	1R4YX@1224,1RTCG@1236,3XMNX@561,COG1762@1,COG1762@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport
C1_03412	198214.SF4349	2.5e-49	201.1	Gammaproteobacteria	ulaB	GO:0003674,GO:0003824,GO:0005215,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0015711,GO:0015749,GO:0015849,GO:0015882,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0034220,GO:0035461,GO:0046942,GO:0051179,GO:0051180,GO:0051181,GO:0051182,GO:0051234,GO:0055085,GO:0071702,GO:0090563,GO:0090585,GO:0098656,GO:1903825,GO:1905039	2.7.1.194,2.7.1.200	ko:K02774,ko:K02822,ko:K03475	ko00052,ko00053,ko01100,ko01120,ko02060,map00052,map00053,map01100,map01120,map02060	M00279,M00283,M00550	R05570,R07671	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.5.1,4.A.7.1		iECABU_c1320.ECABU_c24230,iECH74115_1262.ECH74115_3072,iECSP_1301.ECSP_2888,iECW_1372.ECW_m2294,iECs_1301.ECs2896,iEKO11_1354.EKO11_1661,iEcSMS35_1347.EcSMS35_0971,iSDY_1059.SDY_4363,iSF_1195.SF2155,iSFxv_1172.SFxv_2384,iS_1188.S2281,iWFL_1372.ECW_m2294,iZ_1308.Z3256,ic_1306.c2618	Bacteria	1RET1@1224,1S47F@1236,COG3414@1,COG3414@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport
C1_03413	469008.B21_04022	4.6e-255	886.7	Escherichia	ulaA	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0015711,GO:0015749,GO:0015849,GO:0015882,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0034220,GO:0035461,GO:0042802,GO:0044464,GO:0046942,GO:0051179,GO:0051180,GO:0051181,GO:0051182,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090585,GO:0098656,GO:1903825,GO:1905039	2.7.1.194	ko:K02822,ko:K03475	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	M00283,M00550	R07671	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.7.1		iB21_1397.B21_04022,iEC55989_1330.EC55989_4750,iECBD_1354.ECBD_3841,iECB_1328.ECB_04060,iECD_1391.ECD_04060,iECIAI1_1343.ECIAI1_4426,iECO111_1330.ECO111_5021,iETEC_1333.ETEC_4539,iEcSMS35_1347.EcSMS35_4664,iYL1228.KPN_04586	Bacteria	1MWNR@1224,1RP9S@1236,3XME4@561,COG3037@1,COG3037@2	NA|NA|NA	S	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport
C1_03414	155864.EDL933_5537	1.9e-216	758.1	Escherichia	ulaG	GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0005996,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0008150,GO:0008152,GO:0009056,GO:0009109,GO:0009111,GO:0009987,GO:0016052,GO:0016054,GO:0016787,GO:0016788,GO:0019752,GO:0019852,GO:0019854,GO:0030145,GO:0035460,GO:0042365,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046365,GO:0046395,GO:0046872,GO:0046914,GO:0051186,GO:0051187,GO:0052689,GO:0071704,GO:1901575		ko:K03476	ko00053,ko01100,ko01120,map00053,map01100,map01120	M00550	R07677	RC02793	ko00000,ko00001,ko00002,ko01000			iAF1260.b4192,iAPECO1_1312.APECO1_2200,iBWG_1329.BWG_3904,iEC55989_1330.EC55989_4749,iECDH10B_1368.ECDH10B_4387,iECH74115_1262.ECH74115_5708,iECIAI1_1343.ECIAI1_4425,iECIAI39_1322.ECIAI39_4657,iECO111_1330.ECO111_5022,iECO26_1355.ECO26_5358,iECSE_1348.ECSE_4490,iECSP_1301.ECSP_5292,iECUMN_1333.ECUMN_4725,iECW_1372.ECW_m4554,iEKO11_1354.EKO11_4120,iEcE24377_1341.EcE24377A_4752,iEcHS_1320.EcHS_A4436,iEcolC_1368.EcolC_3821,iJO1366.b4192,iUTI89_1310.UTI89_C4792,iWFL_1372.ECW_m4554,iY75_1357.Y75_RS21830,ic_1306.c5280	Bacteria	1N50Z@1224,1RRU3@1236,3XMMB@561,COG2220@1,COG2220@2	NA|NA|NA	S	Probably catalyzes the hydrolysis of L-ascorbate-6-P into 3-keto-L-gulonate-6-P. Is essential for L-ascorbate utilization under anaerobic conditions
C1_03415	155864.EDL933_5536	4.4e-135	487.3	Escherichia	ulaR	GO:0003674,GO:0005488,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0019842,GO:0030246,GO:0031406,GO:0031418,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0048029,GO:0048037,GO:0050662,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576		ko:K03477					ko00000,ko03000				Bacteria	1QM4U@1224,1RNN2@1236,3XNF0@561,COG1349@1,COG1349@2	NA|NA|NA	K	Represses ulaG and the ulaABCDEF operon
C1_03416	362663.ECP_4435	2.2e-139	501.5	Escherichia	yjfP	GO:0003674,GO:0003824,GO:0016787,GO:0016788,GO:0034338,GO:0052689		ko:K06889					ko00000				Bacteria	1NVFB@1224,1RYJ3@1236,3XMCA@561,COG1073@1,COG1073@2	NA|NA|NA	S	short-chain carboxylesterase activity
C1_03417	155864.EDL933_5534	7.7e-52	209.5	Escherichia	bsmA	GO:0000302,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0009636,GO:0009987,GO:0010035,GO:0033554,GO:0042221,GO:0042493,GO:0042542,GO:0042710,GO:0044010,GO:0044764,GO:0046677,GO:0050896,GO:0051704,GO:0051716,GO:1901700		ko:K09914					ko00000				Bacteria	1NBPH@1224,1SDYX@1236,3XPYU@561,COG3650@1,COG3650@2	NA|NA|NA	S	response to hydrogen peroxide
C1_03418	155864.EDL933_5533	1.2e-42	178.7	Escherichia	yjfN												Bacteria	1N2WZ@1224,1S96B@1236,2DMK5@1,32S43@2,3XQ2Y@561	NA|NA|NA	S	Protein of unknown function (DUF1471)
C1_03419	469008.B21_04016	0.0	1096.6	Escherichia	aidB	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003995,GO:0005488,GO:0005515,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008470,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016491,GO:0016627,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0033554,GO:0042802,GO:0043565,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0055114,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K09456					ko00000				Bacteria	1MU20@1224,1RN7X@1236,3XP17@561,COG1960@1,COG1960@2	NA|NA|NA	I	Part of the adaptive DNA-repair response to alkylating agents. Could prevent alkylation damage by protecting DNA and destroying alkylating agents that have yet to reach their DNA target. Binds to double-stranded DNA with a preference for a DNA region that includes its own promoter. Shows weak isovaleryl-CoA dehydrogenase activity in vitro
C1_03420	155864.EDL933_5531	6.4e-234	816.2	Escherichia	yjfC		3.5.1.78,6.3.1.8	ko:K01460	ko00480,ko01100,map00480,map01100		R01917,R01918	RC00090,RC00096	ko00000,ko00001,ko01000			iECIAI39_1322.ECIAI39_3484	Bacteria	1MW6V@1224,1RQAP@1236,3XQQB@561,COG0754@1,COG0754@2	NA|NA|NA	E	Glutathionylspermidine synthase preATP-grasp
C1_03421	155864.EDL933_5530	1.5e-115	422.2	Escherichia	yjfM												Bacteria	1R90S@1224,1RZWI@1236,3XQJC@561,COG5463@1,COG5463@2	NA|NA|NA	S	Protein of unknown function (DUF1190)
C1_03422	155864.EDL933_5529	2.1e-64	251.5	Escherichia	yjfL	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K08989					ko00000				Bacteria	1N14W@1224,1S3T5@1236,3XQYP@561,COG3766@1,COG3766@2	NA|NA|NA	S	Domain of Unknown Function (DUF350)
C1_03423	316407.85676934	6.8e-124	449.9	Escherichia	yjfK												Bacteria	1MV1M@1224,1RZDJ@1236,28M4V@1,2ZAIQ@2,3XQQF@561	NA|NA|NA	S	Protein of unknown function (DUF2491)
C1_03424	199310.c5266	4.5e-110	404.1	Escherichia	yjfJ	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0042802,GO:0044424,GO:0044444,GO:0044464		ko:K03969					ko00000				Bacteria	1R41V@1224,1RPJ9@1236,3XQUU@561,COG1842@1,COG1842@2	NA|NA|NA	KT	identical protein binding
C1_03425	155864.EDL933_5526	6.3e-64	250.0	Escherichia	yjfI			ko:K04066,ko:K09980	ko03440,map03440				ko00000,ko00001,ko01000,ko03400				Bacteria	1MYU4@1224,1S7KT@1236,3XRAQ@561,COG3789@1,COG3789@2	NA|NA|NA	S	Uncharacterized protein conserved in bacteria (DUF2170)
C1_03426	198214.SF4335	2.2e-131	474.9	Gammaproteobacteria	rlmB	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.185,2.1.1.34	ko:K00556,ko:K03214,ko:K03218,ko:K22132					ko00000,ko01000,ko03009,ko03016				Bacteria	1MWCM@1224,1RN2F@1236,COG0566@1,COG0566@2	NA|NA|NA	J	Specifically methylates the ribose of guanosine 2251 in 23S rRNA
C1_03427	481805.EcolC_3834	0.0	1561.2	Escherichia	rnr	GO:0000175,GO:0003674,GO:0003724,GO:0003824,GO:0004386,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008408,GO:0008997,GO:0009056,GO:0009057,GO:0009266,GO:0009409,GO:0009628,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016896,GO:0017111,GO:0019222,GO:0019439,GO:0034458,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360,GO:1901361,GO:1901575		ko:K12573	ko03018,map03018				ko00000,ko00001,ko01000,ko03016,ko03019				Bacteria	1MUS6@1224,1RMQE@1236,3XNPR@561,COG0557@1,COG0557@2	NA|NA|NA	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
C1_03428	155864.EDL933_5523	3.3e-71	274.2	Escherichia	nsrR	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K13771	ko05132,map05132				ko00000,ko00001,ko03000				Bacteria	1N05H@1224,1S8SJ@1236,3XMZ9@561,COG1959@1,COG1959@2	NA|NA|NA	K	Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress. May require iron for activity
C1_03429	155864.EDL933_5522	3.5e-249	867.1	Escherichia	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046033,GO:0046040,GO:0046085,GO:0046086,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000			iECNA114_1301.ECNA114_4393,iECSF_1327.ECSF_4063,iJN746.PP_4889	Bacteria	1MU5B@1224,1RNEW@1236,3XNIR@561,COG0104@1,COG0104@2	NA|NA|NA	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C1_03430	155864.EDL933_5521	1.2e-28	131.7	Escherichia	yjeT			ko:K09937					ko00000				Bacteria	1N6V7@1224,1SCHT@1236,3XQ4U@561,COG3242@1,COG3242@2	NA|NA|NA	S	Uncharacterized protein conserved in bacteria (DUF2065)
C1_03431	155864.EDL933_5520	3.6e-177	627.5	Escherichia	hflC	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0031233,GO:0032991,GO:0043086,GO:0043170,GO:0044092,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0098796,GO:0140096,GO:1901564		ko:K04087		M00742			ko00000,ko00002,ko01000				Bacteria	1MV7R@1224,1RM8Z@1236,3XM38@561,COG0330@1,COG0330@2	NA|NA|NA	O	HflC and HflK help govern the stability of phage lambda cII protein, and thereby control the lysogenization frequency of phage lambda. HflKC inhibits the SecY-degrading activity of FtsH, possibly helping quality control of integral membrane proteins
C1_03432	155864.EDL933_5519	2e-209	734.9	Escherichia	hflK	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0031233,GO:0032991,GO:0043086,GO:0043170,GO:0044092,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0098796,GO:0140096,GO:1901564		ko:K04088		M00742			ko00000,ko00002,ko01000				Bacteria	1MUM2@1224,1RMUG@1236,3XNW0@561,COG0330@1,COG0330@2	NA|NA|NA	O	HflC and HflK could encode or regulate a protease
C1_03433	155864.EDL933_5518	1.2e-236	825.5	Escherichia	hflX	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006464,GO:0006468,GO:0006518,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018105,GO:0018193,GO:0018209,GO:0019001,GO:0019222,GO:0019538,GO:0019843,GO:0022411,GO:0030554,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032790,GO:0032984,GO:0032988,GO:0034248,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0036211,GO:0036289,GO:0043021,GO:0043022,GO:0043023,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:2000112		ko:K03665					ko00000,ko03009				Bacteria	1MUA0@1224,1RN7V@1236,3XMWA@561,COG2262@1,COG2262@2	NA|NA|NA	J	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C1_03434	1080067.BAZH01000004_gene3854	2e-33	148.3	Citrobacter	hfq	GO:0003674,GO:0003676,GO:0003677,GO:0003681,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006378,GO:0006396,GO:0006397,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016246,GO:0016441,GO:0016458,GO:0017148,GO:0019222,GO:0022607,GO:0022613,GO:0022618,GO:0030423,GO:0031047,GO:0031123,GO:0031124,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032268,GO:0032269,GO:0032270,GO:0034248,GO:0034249,GO:0034250,GO:0034622,GO:0034641,GO:0035194,GO:0040029,GO:0040033,GO:0043170,GO:0043631,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045974,GO:0045975,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051247,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:2000112,GO:2000113		ko:K03666	ko02024,ko03018,ko05111,map02024,map03018,map05111				ko00000,ko00001,ko03019,ko03036				Bacteria	1MZM1@1224,1S8W0@1236,3WYEV@544,COG1923@1,COG1923@2	NA|NA|NA	J	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs
C1_03435	754331.AEME01000001_gene3338	4.2e-175	620.5	Escherichia	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006417,GO:0006725,GO:0006807,GO:0006950,GO:0008033,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009451,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016070,GO:0016740,GO:0016765,GO:0019222,GO:0031323,GO:0031326,GO:0032268,GO:0033554,GO:0034248,GO:0034470,GO:0034605,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0043555,GO:0044237,GO:0044238,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0051716,GO:0052381,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1990497,GO:2000112,GO:2000765	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110		R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016				Bacteria	1MUB2@1224,1RMDU@1236,3XMXU@561,COG0324@1,COG0324@2	NA|NA|NA	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C1_03436	316407.85676921	0.0	1206.8	Escherichia	mutL	GO:0000018,GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0032300,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1990391		ko:K03572	ko03430,map03430				ko00000,ko00001,ko03400				Bacteria	1MV61@1224,1RM89@1236,3XN0H@561,COG0323@1,COG0323@2	NA|NA|NA	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of
C1_03437	316407.85676920	1.2e-241	842.0	Escherichia	amiB	GO:0000003,GO:0000910,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0007049,GO:0008150,GO:0008270,GO:0008745,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0019954,GO:0022402,GO:0022414,GO:0030288,GO:0030313,GO:0031975,GO:0032505,GO:0042597,GO:0043093,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0051301,GO:0061783	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036			iG2583_1286.G2583_4996,iSDY_1059.SDY_3034	Bacteria	1MUQK@1224,1RMP1@1236,3XN8B@561,COG0860@1,COG0860@2	NA|NA|NA	M	N-acetylmuramoyl-L-alanine amidase
C1_03438	198214.SF4323	2e-82	311.6	Gammaproteobacteria	yjeE	GO:0000166,GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043531,GO:0044237,GO:0044238,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363		ko:K06925					ko00000,ko03016				Bacteria	1RGYU@1224,1S6IB@1236,COG0802@1,COG0802@2	NA|NA|NA	S	ATPase or kinase
C1_03439	469008.B21_03996	1.1e-289	1001.9	Escherichia	nnrD	GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0052855,GO:0052856,GO:0052857	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759					ko00000,ko01000				Bacteria	1MU1Q@1224,1RMPS@1236,3XMRN@561,COG0062@1,COG0062@2,COG0063@1,COG0063@2	NA|NA|NA	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C1_03440	316407.85676917	1.7e-223	781.6	Escherichia	queG	GO:0003674,GO:0003824,GO:0006091,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009055,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0022900,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.17.99.6	ko:K18979					ko00000,ko01000,ko03016				Bacteria	1MV1H@1224,1RMD9@1236,3XP23@561,COG1600@1,COG1600@2	NA|NA|NA	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C1_03444	199310.c5249	3.3e-100	370.9	Escherichia	orn	GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004532,GO:0004536,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0008946,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0016896,GO:0019439,GO:0034611,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140097,GO:0140098,GO:1901360,GO:1901361,GO:1901575		ko:K13288	ko03008,map03008				ko00000,ko00001,ko01000,ko03009,ko03019				Bacteria	1R9WX@1224,1S217@1236,3XMZQ@561,COG1949@1,COG1949@2	NA|NA|NA	A	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C1_03445	155864.EDL933_5509	3.5e-199	700.7	Escherichia	rsgA	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0022613,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0036094,GO:0042254,GO:0042274,GO:0043167,GO:0043168,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100		R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009			iAF1260.b4161,iBWG_1329.BWG_3876,iECDH10B_1368.ECDH10B_4356,iECDH1ME8569_1439.ECDH1ME8569_4021,iEKO11_1354.EKO11_4148,iEcDH1_1363.EcDH1_3829,iEcolC_1368.EcolC_3849,iJO1366.b4161,iUMNK88_1353.UMNK88_5099,iY75_1357.Y75_RS21675	Bacteria	1MUEF@1224,1RMMB@1236,3XN8J@561,COG1162@1,COG1162@2	NA|NA|NA	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
C1_03446	155864.EDL933_5508	4.3e-183	647.1	Escherichia	psd	GO:0003674,GO:0003824,GO:0004609,GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0071704,GO:0090407,GO:1901576	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000			iECNA114_1301.ECNA114_4379,iECSF_1327.ECSF_4049	Bacteria	1MVT4@1224,1RN1U@1236,3XNZ3@561,COG0688@1,COG0688@2	NA|NA|NA	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)
C1_03447	155864.EDL933_5507	0.0	2045.0	Escherichia	yjeP			ko:K01421,ko:K02004,ko:K05802,ko:K10953,ko:K12684,ko:K22051	ko05110,map05110	M00258			ko00000,ko00001,ko00002,ko01000,ko02000,ko02042,ko02044	1.A.23.1.1,1.A.23.1.2,1.A.23.1.3,1.B.12.4,3.A.1			Bacteria	1MWSA@1224,1RMYY@1236,3XNQQ@561,COG1511@1,COG1511@2,COG3264@1,COG3264@2	NA|NA|NA	M	Mechanosensitive channel that protects cells against hypoosmotic stress when highly overexpressed. Gates spontaneously in response to increased membrane tension
C1_03448	155864.EDL933_5506	1.1e-272	945.3	Escherichia	yjeM	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K20265	ko02024,map02024				ko00000,ko00001,ko02000	2.A.3.7.1,2.A.3.7.3		iEC042_1314.EC042_1624	Bacteria	1R5N5@1224,1RR4J@1236,3XNY9@561,COG0531@1,COG0531@2	NA|NA|NA	P	transmembrane transporter activity
C1_03449	155864.EDL933_5505	3e-184	651.0	Escherichia	epmA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006430,GO:0006464,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016746,GO:0016755,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052868,GO:0071704,GO:0071915,GO:0072580,GO:0072581,GO:0090304,GO:0140096,GO:1901360,GO:1901564,GO:1901566,GO:1901576		ko:K04568					ko00000,ko01000,ko03012				Bacteria	1MU97@1224,1RMR9@1236,3XP5E@561,COG2269@1,COG2269@2	NA|NA|NA	J	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P) on 'Lys-34'. Catalyzes the ATP-dependent activation of (R)- beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon- amino group of EF-P 'Lys-34'
C1_03450	316407.85676908	0.0	1218.4	Escherichia	frdA	GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363	1.3.5.1,1.3.5.4	ko:K00239,ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000			iECIAI39_1322.ECIAI39_4621,iEcSMS35_1347.EcSMS35_4625,iNJ661.Rv1552,iPC815.YPO0360	Bacteria	1MU5M@1224,1RMU2@1236,3XP24@561,COG1053@1,COG1053@2	NA|NA|NA	C	fumarate reductase, flavoprotein subunit
C1_03451	1440052.EAKF1_ch1673	4.7e-142	510.4	Escherichia	frdB	GO:0000104,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006113,GO:0006928,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0040011,GO:0044085,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0051179,GO:0051536,GO:0051537,GO:0051538,GO:0051539,GO:0051540,GO:0051674,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071840,GO:0071944,GO:0071973,GO:0097588,GO:0098796,GO:0098797,GO:0098803	1.3.5.1,1.3.5.4	ko:K00240,ko:K00245	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000			e_coli_core.b0724,iAF1260.b0724,iBWG_1329.BWG_0583,iEC042_1314.EC042_0742,iECDH10B_1368.ECDH10B_0791,iECDH1ME8569_1439.ECDH1ME8569_0683,iECUMN_1333.ECUMN_0802,iEcDH1_1363.EcDH1_2911,iJO1366.b0724,iJR904.b0724,iNJ661.Rv1553,iPC815.YPO0359,iSDY_1059.SDY_4397,iY75_1357.Y75_RS03765	Bacteria	1MVHS@1224,1RNWR@1236,3XMXG@561,COG0479@1,COG0479@2	NA|NA|NA	C	the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth
C1_03452	155864.EDL933_5502	5.4e-68	263.5	Escherichia	frdC	GO:0000104,GO:0001539,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006091,GO:0006113,GO:0006928,GO:0006996,GO:0008150,GO:0008152,GO:0008177,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0016635,GO:0022607,GO:0030030,GO:0030031,GO:0032991,GO:0040011,GO:0044085,GO:0044237,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0048870,GO:0051179,GO:0051674,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071840,GO:0071944,GO:0071973,GO:0097588,GO:0098796,GO:0098797,GO:0098803		ko:K00246	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002			iYL1228.KPN_04551	Bacteria	1RD34@1224,1S419@1236,3XPS9@561,COG3029@1,COG3029@2	NA|NA|NA	C	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
C1_03453	155864.EDL933_5501	3.4e-61	240.7	Escherichia	frdD	GO:0000104,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0008177,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016627,GO:0016635,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803		ko:K00247	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002			iNJ661.Rv1555,iPC815.YPO0357,ic_1306.c5239	Bacteria	1RDZD@1224,1S3W5@1236,3XPPF@561,COG3080@1,COG3080@2	NA|NA|NA	C	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
C1_03454	469008.B21_03984	1.9e-219	768.1	Escherichia	ampC	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008800,GO:0016787,GO:0016810,GO:0016812,GO:0042597,GO:0044464	3.5.2.6	ko:K01467,ko:K19100,ko:K19215	ko01501,ko02020,map01501,map02020	M00628	R06363	RC01499	br01600,ko00000,ko00001,ko00002,ko01000,ko01504				Bacteria	1MY01@1224,1RNUI@1236,3XNQH@561,COG1680@1,COG1680@2	NA|NA|NA	V	beta-lactamase
C1_03455	155864.EDL933_5499	5.2e-98	363.6	Escherichia	blc	GO:0005575,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0033554,GO:0044462,GO:0044464,GO:0050896,GO:0051716,GO:0071944		ko:K03098,ko:K07071					ko00000,ko04147				Bacteria	1RDAI@1224,1S3PW@1236,3XMI7@561,COG3040@1,COG3040@2	NA|NA|NA	M	Involved in the storage or transport of lipids necessary for membrane maintenance under stressful conditions. Displays a binding preference for lysophospholipids
C1_03456	1440052.EAKF1_ch1678c	2.1e-46	191.4	Escherichia	sugE	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0015893,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046618,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944		ko:K11741					ko00000,ko02000	2.A.7.1			Bacteria	1MZ6P@1224,1S8TD@1236,3XPWE@561,COG2076@1,COG2076@2	NA|NA|NA	U	Quaternary ammonium compound efflux pump. Confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations
C1_03457	155864.EDL933_5497	8.7e-16	88.6	Escherichia	ecnB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K16347,ko:K16348					ko00000,ko02000	9.B.13.1.1			Bacteria	1NH88@1224,1SGIK@1236,3XQ3I@561,COG5510@1,COG5510@2	NA|NA|NA	S	Entericidin EcnA/B family
C1_03458	155864.EDL933_5496	4.5e-13	79.3	Escherichia	ecnA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K16347,ko:K16348					ko00000,ko02000	9.B.13.1.1			Bacteria	1NGDA@1224,1SGAS@1236,3XQ58@561,COG5510@1,COG5510@2	NA|NA|NA	S	Entericidin EcnA/B family
C1_03459	198214.SF4303	1.3e-102	379.0	Gammaproteobacteria	efp	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006448,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0072344,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112,GO:2000113,GO:2001124,GO:2001125		ko:K02356					ko00000,ko03012				Bacteria	1MW2J@1224,1RPW7@1236,COG0231@1,COG0231@2	NA|NA|NA	J	Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation
C1_03460	481805.EcolC_3866	1.3e-193	682.2	Escherichia	kamA	GO:0003674,GO:0003824,GO:0005488,GO:0016853,GO:0016866,GO:0016869,GO:0048037,GO:0051536,GO:0051539,GO:0051540	5.4.3.2	ko:K01843,ko:K19810	ko00310,map00310		R00461	RC00303	ko00000,ko00001,ko01000,ko03012			iECH74115_1262.ECH74115_5662,iECIAI39_1322.ECIAI39_4611,iS_1188.S4569	Bacteria	1MUPJ@1224,1RM84@1236,3XMWB@561,COG1509@1,COG1509@2	NA|NA|NA	C	With EpmA is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P) on 'Lys-34'. EpmB appears to act before EpmA. Displays lysine 2,3-aminomutase activity, producing (R)-beta-lysine from (S)-alpha-lysine (L-lysine). Cannot use (S)-ornithine or (R)- alpha-lysine as a substrate
C1_03461	469008.B21_03977	6.8e-156	556.6	Escherichia	yjeJ												Bacteria	1MWNU@1224,1S0I0@1236,28ICE@1,2Z8ET@2,3XNQ3@561	NA|NA|NA	S	YjeJ-like
C1_03462	637910.ROD_00481	2.1e-161	575.1	Gammaproteobacteria	piv			ko:K07486					ko00000				Bacteria	1MXKJ@1224,1RSCP@1236,COG3547@1,COG3547@2	NA|NA|NA	L	Transposase
C1_03463	155864.EDL933_5492	3.5e-58	230.7	Escherichia	yjeI	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716											Bacteria	1RJBQ@1224,1S6CT@1236,2AGMU@1,316V4@2,3XPWY@561	NA|NA|NA	S	cellular response to DNA damage stimulus
C1_03464	155864.EDL933_5491	2.2e-288	997.7	Escherichia	groL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0008144,GO:0008150,GO:0009266,GO:0009314,GO:0009405,GO:0009408,GO:0009628,GO:0009966,GO:0009967,GO:0009986,GO:0009987,GO:0010646,GO:0010647,GO:0016032,GO:0016462,GO:0016465,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018995,GO:0019058,GO:0019068,GO:0020003,GO:0023051,GO:0023056,GO:0030430,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033643,GO:0033646,GO:0033655,GO:0035639,GO:0035821,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043230,GO:0043656,GO:0043657,GO:0043900,GO:0043903,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044403,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0051817,GO:0052047,GO:0052212,GO:0061077,GO:0065007,GO:0065010,GO:0097159,GO:0097367,GO:0101031,GO:1901222,GO:1901224,GO:1901265,GO:1901363,GO:1902531,GO:1902533,GO:1990220,GO:2000535		ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152				ko00000,ko00001,ko03019,ko03029,ko03110,ko04147				Bacteria	1MURR@1224,1RMTB@1236,3XN1I@561,COG0459@1,COG0459@2	NA|NA|NA	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
C1_03465	1440052.EAKF1_ch1687c	5.3e-44	183.3	Escherichia	groS	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010033,GO:0016032,GO:0016465,GO:0019058,GO:0019068,GO:0032991,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051704,GO:0061077,GO:0101031,GO:1990220		ko:K04078					ko00000,ko03029,ko03110				Bacteria	1MZ2X@1224,1S8YR@1236,3XPUM@561,COG0234@1,COG0234@2	NA|NA|NA	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C1_03466	316407.85676893	2e-233	814.7	Escherichia	yjeH	GO:0000099,GO:0000101,GO:0000102,GO:0001101,GO:0003333,GO:0003674,GO:0005215,GO:0005294,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0009719,GO:0009987,GO:0010033,GO:0010243,GO:0015075,GO:0015171,GO:0015175,GO:0015179,GO:0015191,GO:0015238,GO:0015291,GO:0015297,GO:0015318,GO:0015711,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015820,GO:0015821,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0043200,GO:0043865,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0070887,GO:0071229,GO:0071230,GO:0071310,GO:0071417,GO:0071495,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0098655,GO:0098656,GO:1901680,GO:1901682,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039		ko:K16263					ko00000,ko02000	2.A.3.13			Bacteria	1NCSX@1224,1RND7@1236,3XNCR@561,COG0531@1,COG0531@2	NA|NA|NA	E	L-methionine secondary active transmembrane transporter activity
C1_03467	316407.85676892	1.1e-75	289.3	Escherichia	fxsA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016021,GO:0031224,GO:0044425,GO:0044464,GO:0071944		ko:K07113					ko00000				Bacteria	1MZJJ@1224,1S8XU@1236,3XPKI@561,COG3030@1,COG3030@2	NA|NA|NA	S	Suppressor of F exclusion of phage T7
C1_03468	155864.EDL933_5486	1.7e-273	948.0	Escherichia	aspA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006531,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008797,GO:0009058,GO:0009066,GO:0009893,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016053,GO:0016829,GO:0016840,GO:0016841,GO:0019222,GO:0019752,GO:0030162,GO:0031323,GO:0031325,GO:0032268,GO:0032270,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046394,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0070613,GO:0071704,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1903317,GO:1903319	4.3.1.1	ko:K01744	ko00250,ko01100,map00250,map01100		R00490	RC00316,RC02799	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_2250,iECs_1301.ECs5120,iG2583_1286.G2583_4966,iSBO_1134.SBO_4317,iSDY_1059.SDY_4444,iSF_1195.SF4293,iSFxv_1172.SFxv_4682,iSSON_1240.SSON_4322,iS_1188.S4560,iUTI89_1310.UTI89_C4736,iYL1228.KPN_04529,iZ_1308.Z5744,ic_1306.c5222	Bacteria	1R9JY@1224,1RP5Z@1236,3XP1Y@561,COG1027@1,COG1027@2	NA|NA|NA	E	Aspartate ammonia-lyase
C1_03469	198214.SF4292	1.4e-226	792.0	Gammaproteobacteria	dcuA	GO:0003674,GO:0005215,GO:0005310,GO:0005342,GO:0005469,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006855,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015138,GO:0015141,GO:0015238,GO:0015291,GO:0015297,GO:0015318,GO:0015556,GO:0015711,GO:0015740,GO:0015741,GO:0015744,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071422,GO:0071702,GO:0071944,GO:0098656,GO:1903825,GO:1905039		ko:K07791,ko:K07792	ko02020,map02020				ko00000,ko00001,ko02000	2.A.13.1		iECDH1ME8569_1439.ECDH1ME8569_3996,iEcDH1_1363.EcDH1_3854,iUMNK88_1353.UMNK88_4987	Bacteria	1MVHH@1224,1RPTE@1236,COG2704@1,COG2704@2	NA|NA|NA	S	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C1_03470	155864.EDL933_5484	6.9e-56	223.0	Escherichia	cutA	GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0010035,GO:0010038,GO:0016043,GO:0022607,GO:0042221,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0046688,GO:0046872,GO:0046914,GO:0050896,GO:0051259,GO:0051260,GO:0065003,GO:0071840	4.2.3.1	ko:K01733,ko:K03926	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000				Bacteria	1N6TN@1224,1SCFM@1236,3XPPZ@561,COG1324@1,COG1324@2	NA|NA|NA	P	Involved in resistance toward heavy metals
C1_03471	469008.B21_03968	0.0	1107.4	Escherichia	dsbD	GO:0003674,GO:0003756,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008152,GO:0009266,GO:0009628,GO:0009898,GO:0009987,GO:0015035,GO:0015036,GO:0016020,GO:0016021,GO:0016043,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0017004,GO:0019725,GO:0022607,GO:0031224,GO:0031226,GO:0034622,GO:0042221,GO:0042493,GO:0042592,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0055114,GO:0065003,GO:0065007,GO:0065008,GO:0071502,GO:0071840,GO:0071944,GO:0098552,GO:0098562,GO:0140096	1.8.1.8	ko:K04084					ko00000,ko01000,ko03110	5.A.1.1		iECSE_1348.ECSE_4435	Bacteria	1MU8W@1224,1RPF7@1236,3XMTA@561,COG4232@1,COG4232@2	NA|NA|NA	CO	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps
C1_03472	155864.EDL933_5482	1.1e-104	386.0	Escherichia	yjdC	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2001141											Bacteria	1RAPB@1224,1RPSA@1236,3XMS0@561,COG1309@1,COG1309@2	NA|NA|NA	K	nucleic acid-templated transcription
C1_03474	155864.EDL933_5481	7.3e-294	1015.8	Escherichia	cadC	GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141		ko:K03765					ko00000,ko03000				Bacteria	1PYUK@1224,1SYU4@1236,3XP26@561,COG3710@1,COG3710@2	NA|NA|NA	K	transcriptional activator
C1_03475	155864.EDL933_5480	1.7e-246	858.2	Escherichia	cadB	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0006950,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0008519,GO:0009268,GO:0009628,GO:0009987,GO:0010447,GO:0015075,GO:0015077,GO:0015078,GO:0015101,GO:0015171,GO:0015174,GO:0015179,GO:0015189,GO:0015238,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015297,GO:0015298,GO:0015318,GO:0015490,GO:0015491,GO:0015672,GO:0015695,GO:0015696,GO:0015711,GO:0015802,GO:0015807,GO:0015839,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0033554,GO:0034220,GO:0042221,GO:0042493,GO:0042802,GO:0043872,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071214,GO:0071467,GO:0071468,GO:0071702,GO:0071705,GO:0071944,GO:0072488,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:0099516,GO:0104004,GO:1902022,GO:1902475,GO:1902600,GO:1903401,GO:1903825,GO:1905039,GO:1990451,GO:1990822		ko:K03294,ko:K03756,ko:K03757,ko:K03759					ko00000,ko02000	2.A.3.2		iAF1260.b0692,iAF1260.b4132,iAPECO1_1312.APECO1_2321,iB21_1397.B21_00640,iB21_1397.B21_03965,iBWG_1329.BWG_0551,iBWG_1329.BWG_3846,iE2348C_1286.E2348C_0581,iE2348C_1286.E2348C_4459,iEC042_1314.EC042_4498,iEC55989_1330.EC55989_4625,iECABU_c1320.ECABU_c07430,iECABU_c1320.ECABU_c46860,iECBD_1354.ECBD_2969,iECBD_1354.ECBD_3898,iECB_1328.ECB_00648,iECB_1328.ECB_04003,iECDH10B_1368.ECDH10B_0758,iECDH10B_1368.ECDH10B_4325,iECDH1ME8569_1439.ECDH1ME8569_0650,iECD_1391.ECD_00648,iECD_1391.ECD_04003,iECH74115_1262.ECH74115_5648,iECIAI1_1343.ECIAI1_0668,iECIAI1_1343.ECIAI1_4365,iECNA114_1301.ECNA114_0628,iECNA114_1301.ECNA114_4318,iECO103_1326.ECO103_0686,iECO103_1326.ECO103_4884,iECO26_1355.ECO26_0754,iECO26_1355.ECO26_5227,iECO26_1355.ECO26_5244,iECOK1_1307.ECOK1_4644,iECP_1309.ECP_0710,iECP_1309.ECP_4376,iECS88_1305.ECS88_4636,iECSE_1348.ECSE_0751,iECSE_1348.ECSE_4432,iECSF_1327.ECSF_0627,iECSF_1327.ECSF_4021,iECSP_1301.ECSP_5232,iECUMN_1333.ECUMN_4666,iECW_1372.ECW_m0742,iECW_1372.ECW_m4493,iECs_1301.ECs5114,iEKO11_1354.EKO11_3188,iEKO11_1354.EKO11_4186,iETEC_1333.ETEC_0708,iETEC_1333.ETEC_4443,iEcDH1_1363.EcDH1_2945,iEcE24377_1341.EcE24377A_4687,iEcHS_1320.EcHS_A4373,iEcSMS35_1347.EcSMS35_4601,iEcolC_1368.EcolC_2964,iEcolC_1368.EcolC_3895,iG2583_1286.G2583_4959,iJO1366.b0692,iJO1366.b4132,iJR904.b0692,iJR904.b4132,iLF82_1304.LF82_0255,iNRG857_1313.NRG857_20730,iSSON_1240.SSON_0643,iUMN146_1321.UM146_20900,iUMNK88_1353.UMNK88_4999,iUMNK88_1353.UMNK88_728,iUTI89_1310.UTI89_C4729,iWFL_1372.ECW_m0742,iWFL_1372.ECW_m4493,iY75_1357.Y75_RS03590,iY75_1357.Y75_RS21520,ic_1306.c0776,ic_1306.c5141	Bacteria	1MUA2@1224,1RRKS@1236,3XMNQ@561,COG0531@1,COG0531@2	NA|NA|NA	E	cadaverine lysine antiporter
C1_03476	155864.EDL933_5479	0.0	1460.7	Escherichia	cadA	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006553,GO:0006554,GO:0006807,GO:0008150,GO:0008152,GO:0008923,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016831,GO:0017076,GO:0019001,GO:0019752,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0071704,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	4.1.1.17,4.1.1.18,4.1.1.19	ko:K01581,ko:K01582,ko:K01584,ko:K01585	ko00310,ko00330,ko00480,ko00960,ko01100,ko01110,ko01130,map00310,map00330,map00480,map00960,map01100,map01110,map01130	M00133,M00134	R00462,R00566,R00670	RC00299	ko00000,ko00001,ko00002,ko01000			iEC042_1314.EC042_4483,iECW_1372.ECW_m0743,iEcHS_1320.EcHS_A3126,iSbBS512_1146.SbBS512_E0179,iWFL_1372.ECW_m0743	Bacteria	1MWK4@1224,1RMVF@1236,3XMCQ@561,COG1982@1,COG1982@2	NA|NA|NA	E	lysine decarboxylase
C1_03477	316407.85676883	9e-270	935.6	Escherichia	yjdL	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006857,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015333,GO:0015672,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0034220,GO:0035442,GO:0035443,GO:0035672,GO:0035673,GO:0042886,GO:0042887,GO:0042937,GO:0042938,GO:0042939,GO:0044425,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071916,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600,GO:1904680		ko:K03305					ko00000	2.A.17		iECO103_1326.ECO103_0702,iEcSMS35_1347.EcSMS35_4599	Bacteria	1MW6W@1224,1RM8P@1236,3XN0T@561,COG3104@1,COG3104@2	NA|NA|NA	E	Proton-dependent permease that transports di- and tripeptides. Shows significantly higher specificity towards dipeptides than tripeptides. Has a preference for dipeptides with a C-terminal Lys residue. Can bind Ala-Lys, Lys-Ala, Ala-Ala. Can also transport alanine and trialanine
C1_03478	155864.EDL933_5477	1.1e-289	1001.9	Escherichia	lysS	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006430,GO:0006518,GO:0006520,GO:0006629,GO:0006644,GO:0006650,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009059,GO:0009405,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019637,GO:0019752,GO:0030312,GO:0030322,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0040007,GO:0042221,GO:0042391,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046471,GO:0046483,GO:0046486,GO:0046677,GO:0046872,GO:0050896,GO:0051704,GO:0065007,GO:0065008,GO:0071704,GO:0071944,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iAF1260.b4129,iECDH1ME8569_1439.ECDH1ME8569_3989,iECW_1372.ECW_m4490,iEcDH1_1363.EcDH1_3862,iJN678.lysS,iJO1366.b4129,iWFL_1372.ECW_m4490	Bacteria	1MX1V@1224,1RMJN@1236,3XQHS@561,COG1190@1,COG1190@2	NA|NA|NA	J	Belongs to the class-II aminoacyl-tRNA synthetase family
C1_03479	637910.ROD_15891	9.1e-12	75.5	Citrobacter	ydcX												Bacteria	1N8R7@1224,1SCPI@1236,2E4I9@1,32ZDC@2,3WYYE@544	NA|NA|NA	S	Toxin GhoT_OrtT
C1_03481	155864.EDL933_5474	3.2e-43	180.6	Escherichia	yjdJ			ko:K06975					ko00000				Bacteria	1N6YS@1224,1S6I3@1236,3XPWS@561,COG2388@1,COG2388@2	NA|NA|NA	S	GCN5-related N-acetyl-transferase
C1_03482	155864.EDL933_5473	2.6e-38	164.1	Escherichia	yjdI		1.6.3.4	ko:K07397,ko:K22405					ko00000,ko01000				Bacteria	1N10V@1224,1S95I@1236,3XQ06@561,COG3592@1,COG3592@2	NA|NA|NA	S	Divergent 4Fe-4S mono-cluster
C1_03483	155864.EDL933_5471	1.4e-295	1021.5	Escherichia	dcuS	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016020,GO:0016021,GO:0016043,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019219,GO:0019222,GO:0019538,GO:0022607,GO:0023014,GO:0023052,GO:0031224,GO:0031226,GO:0031323,GO:0031326,GO:0035556,GO:0036211,GO:0042802,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051259,GO:0051260,GO:0051716,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0140096,GO:1901564,GO:1903506,GO:2000112,GO:2001141	2.7.13.3	ko:K02476,ko:K07700,ko:K07701,ko:K11614	ko02020,map02020	M00486,M00488,M00490			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	1MXQ5@1224,1RNRF@1236,3XMMT@561,COG3290@1,COG3290@2	NA|NA|NA	T	Member of the two-component regulatory system DcuR DcuS. Involved in the C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respiratory system (frdABCD
C1_03484	155864.EDL933_5470	5.5e-135	486.9	Escherichia	dcuR	GO:0000160,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0023052,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035556,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141		ko:K02475,ko:K07702,ko:K07703,ko:K11615	ko02020,map02020	M00486,M00488,M00490			ko00000,ko00001,ko00002,ko02022				Bacteria	1MUC7@1224,1RNEF@1236,3XN3Z@561,COG4565@1,COG4565@2	NA|NA|NA	K	Member of the two-component regulatory system DcuR DcuS. Involved in the C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respiratory system (frdABCD
C1_03485	198214.SF4100	4.3e-242	843.6	Gammaproteobacteria	dcuB	GO:0003674,GO:0005215,GO:0005310,GO:0005342,GO:0005469,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006855,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015138,GO:0015141,GO:0015238,GO:0015291,GO:0015297,GO:0015318,GO:0015556,GO:0015711,GO:0015740,GO:0015741,GO:0015744,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071422,GO:0071702,GO:0071944,GO:0098656,GO:1903825,GO:1905039		ko:K07791,ko:K07792	ko02020,map02020				ko00000,ko00001,ko02000	2.A.13.1		iECDH1ME8569_1439.ECDH1ME8569_3996,iEcDH1_1363.EcDH1_3854,iUMNK88_1353.UMNK88_4987	Bacteria	1MVHH@1224,1RPTE@1236,COG2704@1,COG2704@2	NA|NA|NA	S	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C1_03486	199310.c5127	0.0	1104.7	Escherichia	fumB	GO:0003674,GO:0003824,GO:0004333,GO:0005488,GO:0005515,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016860,GO:0016862,GO:0016999,GO:0017144,GO:0019752,GO:0033554,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0047808,GO:0048037,GO:0050163,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0055114,GO:0071704,GO:0072350	4.2.1.2,4.2.1.32	ko:K01676,ko:K01677,ko:K01678,ko:K03780	ko00020,ko00620,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00630,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00339,R01082	RC00443,RC01382	ko00000,ko00001,ko00002,ko01000			iEC55989_1330.EC55989_1778,iPC815.YPO3335,iSBO_1134.SBO_2920	Bacteria	1MUV9@1224,1RN8U@1236,3XNXU@561,COG1838@1,COG1838@2,COG1951@1,COG1951@2	NA|NA|NA	C	Catalyzes the reversible hydration of fumarate to (S)- malate
C1_03487	155864.EDL933_5467	8.8e-113	412.9	Escherichia	yjdF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K08984					ko00000				Bacteria	1N7NB@1224,1RS4F@1236,3XMPA@561,COG3647@1,COG3647@2	NA|NA|NA	S	Predicted membrane protein (DUF2238)
C1_03488	469008.B21_03952	2.2e-260	904.4	Escherichia	melB	GO:0003674,GO:0005215,GO:0005402,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008150,GO:0008324,GO:0008643,GO:0015075,GO:0015077,GO:0015081,GO:0015144,GO:0015154,GO:0015156,GO:0015157,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015487,GO:0015592,GO:0015672,GO:0015765,GO:0015766,GO:0015769,GO:0015772,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034219,GO:0034220,GO:0035725,GO:0043887,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1901264,GO:1901505,GO:1901656		ko:K03292,ko:K11104,ko:K16139					ko00000,ko02000	2.A.2,2.A.2.1		iBWG_1329.BWG_3833,iECDH10B_1368.ECDH10B_4312,iECDH1ME8569_1439.ECDH1ME8569_3979,iEKO11_1354.EKO11_4199,iEcDH1_1363.EcDH1_3872	Bacteria	1MVUM@1224,1RP5J@1236,3XQX4@561,COG2211@1,COG2211@2	NA|NA|NA	P	Responsible for melibiose and other galactoside transport. It is capable of using hydrogen, sodium, and lithium cations as coupling cations for cotransport, depending on the particular sugar transported (symport system)
C1_03489	481805.EcolC_3908	6.4e-270	936.0	Escherichia	melA	GO:0000166,GO:0003674,GO:0003824,GO:0004553,GO:0004557,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005994,GO:0005995,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0015925,GO:0016052,GO:0016787,GO:0016798,GO:0030145,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046352,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0051287,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901575	3.2.1.122,3.2.1.22,3.2.1.86	ko:K01222,ko:K01232,ko:K07406	ko00010,ko00052,ko00500,ko00561,ko00600,ko00603,map00010,map00052,map00500,map00561,map00600,map00603		R00837,R00838,R00839,R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05133,R05134,R05549,R05961,R06091,R06113	RC00049,RC00059,RC00171,RC00451,RC00714	ko00000,ko00001,ko01000		GH4,GT4	iECH74115_1262.ECH74115_5633,iECSP_1301.ECSP_5218,iECs_1301.ECs5101	Bacteria	1NI6G@1224,1RN45@1236,3XQ8R@561,COG1486@1,COG1486@2	NA|NA|NA	G	melibiose metabolic process
C1_03490	199310.c5123	1.3e-173	615.5	Escherichia	melR	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:2000112,GO:2001141	2.1.1.63,3.1.31.1,3.2.2.21	ko:K01174,ko:K03490,ko:K10778,ko:K13529,ko:K15051	ko03410,map03410				ko00000,ko00001,ko01000,ko03000,ko03400				Bacteria	1R4BQ@1224,1RTAM@1236,3XQ6C@561,COG2169@1,COG2169@2	NA|NA|NA	K	Transcription activator for the expression of the melAB operon. MelR binds at two sites located upstream of the melAB transcription site
C1_03491	316407.85676869	0.0	1558.5	Escherichia	adiA	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004586,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006553,GO:0006554,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0006873,GO:0006885,GO:0008144,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0008792,GO:0008923,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009065,GO:0009066,GO:0009068,GO:0009308,GO:0009309,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016831,GO:0017076,GO:0019001,GO:0019725,GO:0019752,GO:0019842,GO:0030003,GO:0030004,GO:0030170,GO:0030641,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0036094,GO:0042401,GO:0042592,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0045852,GO:0046395,GO:0048037,GO:0048878,GO:0050662,GO:0050801,GO:0051453,GO:0051454,GO:0055067,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0070279,GO:0071704,GO:0097159,GO:0097164,GO:0097216,GO:0097367,GO:0098771,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606	4.1.1.17,4.1.1.18,4.1.1.19	ko:K01581,ko:K01582,ko:K01584,ko:K01585	ko00310,ko00330,ko00480,ko00960,ko01100,ko01110,ko01130,map00310,map00330,map00480,map00960,map01100,map01110,map01130	M00133,M00134	R00462,R00566,R00670	RC00299	ko00000,ko00001,ko00002,ko01000			iEC042_1314.EC042_4483,iEcHS_1320.EcHS_A3126,iSbBS512_1146.SbBS512_E0179	Bacteria	1MWK4@1224,1RMVF@1236,3XNRQ@561,COG1982@1,COG1982@2	NA|NA|NA	E	Biodegradative arginine decarboxylase
C1_03492	155864.EDL933_5461	1.3e-139	502.3	Escherichia	adiY	GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141		ko:K03755,ko:K11920,ko:K21905,ko:K21906					ko00000,ko03000				Bacteria	1RBK1@1224,1S36K@1236,3XQP6@561,COG2207@1,COG2207@2	NA|NA|NA	K	regulatory protein
C1_03493	155864.EDL933_5460	2.9e-246	857.4	Escherichia	adiC	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0006873,GO:0006885,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015171,GO:0015174,GO:0015181,GO:0015291,GO:0015297,GO:0015318,GO:0015711,GO:0015802,GO:0015809,GO:0015849,GO:0016020,GO:0016021,GO:0019725,GO:0022804,GO:0022857,GO:0030003,GO:0030004,GO:0030641,GO:0031224,GO:0031226,GO:0034220,GO:0042592,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0045852,GO:0046942,GO:0046943,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0051453,GO:0051454,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:0098771,GO:1903825,GO:1903826,GO:1905039,GO:1990822		ko:K03294,ko:K03756,ko:K03757,ko:K03759					ko00000,ko02000	2.A.3.2		iAF1260.b0692,iAF1260.b4132,iAPECO1_1312.APECO1_2321,iB21_1397.B21_00640,iB21_1397.B21_03965,iBWG_1329.BWG_0551,iBWG_1329.BWG_3846,iE2348C_1286.E2348C_0581,iE2348C_1286.E2348C_4459,iEC042_1314.EC042_4498,iEC55989_1330.EC55989_4625,iECABU_c1320.ECABU_c07430,iECABU_c1320.ECABU_c46860,iECBD_1354.ECBD_2969,iECBD_1354.ECBD_3898,iECB_1328.ECB_00648,iECB_1328.ECB_04003,iECDH10B_1368.ECDH10B_0758,iECDH10B_1368.ECDH10B_4325,iECDH1ME8569_1439.ECDH1ME8569_0650,iECD_1391.ECD_00648,iECD_1391.ECD_04003,iECH74115_1262.ECH74115_5648,iECIAI1_1343.ECIAI1_0668,iECIAI1_1343.ECIAI1_4365,iECNA114_1301.ECNA114_0628,iECNA114_1301.ECNA114_4318,iECO103_1326.ECO103_0686,iECO103_1326.ECO103_4884,iECO26_1355.ECO26_0754,iECO26_1355.ECO26_5227,iECO26_1355.ECO26_5244,iECOK1_1307.ECOK1_4644,iECP_1309.ECP_0710,iECP_1309.ECP_4376,iECS88_1305.ECS88_4636,iECSE_1348.ECSE_0751,iECSE_1348.ECSE_4432,iECSF_1327.ECSF_0627,iECSF_1327.ECSF_4021,iECSP_1301.ECSP_5232,iECUMN_1333.ECUMN_4666,iECW_1372.ECW_m0742,iECW_1372.ECW_m4493,iECs_1301.ECs5114,iEKO11_1354.EKO11_3188,iEKO11_1354.EKO11_4186,iETEC_1333.ETEC_0708,iETEC_1333.ETEC_4443,iEcDH1_1363.EcDH1_2945,iEcE24377_1341.EcE24377A_4687,iEcHS_1320.EcHS_A4373,iEcSMS35_1347.EcSMS35_4601,iEcolC_1368.EcolC_2964,iEcolC_1368.EcolC_3895,iG2583_1286.G2583_4959,iJO1366.b0692,iJO1366.b4132,iJR904.b0692,iJR904.b4132,iLF82_1304.LF82_0255,iNRG857_1313.NRG857_20730,iSSON_1240.SSON_0643,iUMN146_1321.UM146_20900,iUMNK88_1353.UMNK88_4999,iUMNK88_1353.UMNK88_728,iUTI89_1310.UTI89_C4729,iWFL_1372.ECW_m0742,iWFL_1372.ECW_m4493,iY75_1357.Y75_RS03590,iY75_1357.Y75_RS21520,ic_1306.c0776,ic_1306.c5141	Bacteria	1MUA2@1224,1RRKS@1236,3XNHB@561,COG0531@1,COG0531@2	NA|NA|NA	E	Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach
C1_03494	469008.B21_03946	0.0	1087.4	Escherichia	eptA	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016772,GO:0016776,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046401,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.7.8.42,2.7.8.43	ko:K03760,ko:K12975,ko:K19353	ko00540,ko01503,map00540,map01503	M00722,M00723	R11204,R11205,R11555,R11556,R11557	RC00002,RC00017,RC00428	ko00000,ko00001,ko00002,ko01000,ko01005			iSSON_1240.SSON_3844	Bacteria	1MWS7@1224,1RMNG@1236,3XMGY@561,COG2194@1,COG2194@2	NA|NA|NA	S	Catalyzes the addition of a phosphoethanolamine moiety to the lipid A. The phosphoethanolamine modification is required for resistance to polymyxin (By similarity)
C1_03495	155864.EDL933_5458	3.2e-121	441.0	Escherichia													Bacteria	1N0YI@1224,1RPNH@1236,3XNK2@561,COG0745@1,COG0745@2	NA|NA|NA	K	transcriptional regulatory protein
C1_03496	155864.EDL933_5457	2e-197	694.9	Escherichia	basS	GO:0000155,GO:0000160,GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0010041,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0017076,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0042221,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	2.7.13.3	ko:K07643,ko:K07645,ko:K07653,ko:K18351	ko01502,ko01503,ko02020,ko02024,map01502,map01503,map02020,map02024	M00451,M00453,M00460,M00651,M00658,M00721,M00722			ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022				Bacteria	1QTSX@1224,1RQMH@1236,3XNJ7@561,COG0642@1,COG0642@2	NA|NA|NA	T	Sensor protein basS
C1_03498	199310.c5116	6.7e-276	956.1	Escherichia	proP	GO:0003333,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0006950,GO:0006970,GO:0006972,GO:0007154,GO:0007165,GO:0007231,GO:0008150,GO:0008324,GO:0008519,GO:0009628,GO:0009651,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015101,GO:0015199,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015651,GO:0015652,GO:0015653,GO:0015672,GO:0015695,GO:0015696,GO:0015697,GO:0015711,GO:0015804,GO:0015824,GO:0015838,GO:0015849,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0023052,GO:0031224,GO:0031226,GO:0031460,GO:0033554,GO:0034220,GO:0035524,GO:0042538,GO:0043090,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0065007,GO:0071214,GO:0071470,GO:0071472,GO:0071474,GO:0071475,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0072349,GO:0072488,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098660,GO:0098662,GO:0098739,GO:0104004,GO:1902600,GO:1903825,GO:1905039,GO:1905647		ko:K03761,ko:K03762,ko:K08172,ko:K08173					ko00000,ko02000	2.A.1.6,2.A.1.6.2,2.A.1.6.4,2.A.1.6.6		iAPECO1_1312.APECO1_1067,iEC55989_1330.EC55989_2218,iECNA114_1301.ECNA114_2055,iECS88_1305.ECS88_2049,iLF82_1304.LF82_2131,iNRG857_1313.NRG857_09945,iSSON_1240.SSON_4052,iUTI89_1310.UTI89_C4705,ic_1306.c5116	Bacteria	1MU46@1224,1RNIM@1236,3XP07@561,COG0477@1,COG0477@2	NA|NA|NA	EGP	Proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response
C1_03499	155864.EDL933_5455	1.5e-166	592.0	Escherichia	yjcZ												Bacteria	1PNJ3@1224,1T18N@1236,28MYC@1,2ZB58@2,3XRMT@561	NA|NA|NA	S	YjcZ-like protein
C1_03500	155864.EDL933_5454	0.0	1438.7	Escherichia	yjdA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0007059,GO:0008150,GO:0009987,GO:0044424,GO:0044444,GO:0044464											Bacteria	1N3I9@1224,1RSA8@1236,3XMJU@561,COG0699@1,COG0699@2	NA|NA|NA	S	Important for the colocalization of sister nascent DNA strands after replication fork passage during DNA replication, and for positioning and subsequent partitioning of sister chromosomes. Does not have GTPase activity on its own
C1_03501	155864.EDL933_5453	1.3e-59	235.3	Escherichia	phnA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K06193	ko01120,map01120				ko00000				Bacteria	1RGUU@1224,1S60W@1236,3XPRW@561,COG2824@1,COG2824@2	NA|NA|NA	P	PhnA Zinc-Ribbon
C1_03502	155864.EDL933_5452	3.1e-80	304.3	Escherichia	phnB			ko:K04750					ko00000				Bacteria	1N0S4@1224,1S93U@1236,3XM9N@561,COG2764@1,COG2764@2	NA|NA|NA	S	3-demethylubiquinone-9 3-methyltransferase
C1_03503	469008.B21_03938	1.9e-141	508.4	Escherichia	phnC		3.6.3.28	ko:K02041	ko02010,map02010	M00223			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.9			Bacteria	1MVE9@1224,1RRV7@1236,3XRIR@561,COG3638@1,COG3638@2	NA|NA|NA	P	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C1_03504	316407.85676857	1.3e-187	662.1	Gammaproteobacteria	phnD			ko:K02044	ko02010,map02010	M00223			ko00000,ko00001,ko00002,ko02000	3.A.1.9			Bacteria	1MXD8@1224,1RR46@1236,COG3221@1,COG3221@2	NA|NA|NA	P	Phosphonate ABC transporter
C1_03505	469008.B21_03936	3.2e-141	507.7	Gammaproteobacteria	phnE		3.6.1.63	ko:K02042,ko:K06162	ko00440,ko02010,map00440,map02010	M00223	R10186	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.9			Bacteria	1MW4F@1224,1RQ3V@1236,COG3639@1,COG3639@2	NA|NA|NA	P	Phosphonate ABC transporter
C1_03506	316407.85676855	2.1e-134	485.0	Escherichia	phnF			ko:K02043,ko:K03710					ko00000,ko03000				Bacteria	1Q856@1224,1RQ3N@1236,3XQWA@561,COG2188@1,COG2188@2	NA|NA|NA	K	Transcriptional regulator
C1_03507	693444.D782_4167	5e-78	297.0	Gammaproteobacteria	phnG	GO:0005575,GO:0006793,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0019634,GO:0019637,GO:0019700,GO:0032991,GO:0044237,GO:0046434,GO:0061694,GO:0061695,GO:0071704,GO:1901575,GO:1902494,GO:1904176,GO:1990234	2.7.8.37	ko:K06166	ko00440,map00440		R10185	RC00005,RC00063	ko00000,ko00001,ko01000				Bacteria	1MZTZ@1224,1S3FT@1236,COG3624@1,COG3624@2	NA|NA|NA	P	Phosphonate C-P lyase system protein PhnG
C1_03508	362663.ECP_4343	4.5e-103	380.6	Escherichia	phnH	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0006793,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0019634,GO:0019637,GO:0019700,GO:0032991,GO:0042802,GO:0044237,GO:0046434,GO:0061694,GO:0061695,GO:0071704,GO:1901575,GO:1902494,GO:1904176,GO:1990234	2.7.8.37	ko:K06165	ko00440,map00440		R10185	RC00005,RC00063	ko00000,ko00001,ko01000				Bacteria	1RHXN@1224,1RZR8@1236,3XQ24@561,COG3625@1,COG3625@2	NA|NA|NA	P	Together with PhnG, PhnI and PhnL is required for the transfer of the ribose triphosphate moiety from ATP to methyl phosphonate
C1_03509	362663.ECP_4342	2.7e-199	701.0	Gammaproteobacteria	phnI	GO:0003674,GO:0003824,GO:0005575,GO:0006793,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0019634,GO:0019637,GO:0019700,GO:0032991,GO:0044237,GO:0046434,GO:0061693,GO:0061694,GO:0061695,GO:0071704,GO:1901575,GO:1902494,GO:1904176,GO:1990234	2.7.8.37	ko:K06164	ko00440,map00440		R10185	RC00005,RC00063	ko00000,ko00001,ko01000				Bacteria	1MUBA@1224,1RRT5@1236,COG3626@1,COG3626@2	NA|NA|NA	P	Phosphonate
C1_03510	469008.B21_03930	1.2e-160	572.4	Gammaproteobacteria	phnJ	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0006793,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016829,GO:0018835,GO:0019634,GO:0019637,GO:0019700,GO:0032991,GO:0044237,GO:0046434,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0098848,GO:1901575,GO:1902494,GO:1904176	4.7.1.1	ko:K06163	ko00440,map00440		R10204	RC03078,RC03079	ko00000,ko00001,ko01000				Bacteria	1MV7T@1224,1RNI7@1236,COG3627@1,COG3627@2	NA|NA|NA	H	Catalyzes the breakage of the C-P bond in alpha-D-ribose 1-methylphosphonate 5-phosphate (PRPn) forming alpha-D-ribose
C1_03511	316407.85676850	1.4e-136	492.3	Gammaproteobacteria	phnK	GO:0005575,GO:0006793,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0019634,GO:0019637,GO:0019700,GO:0032991,GO:0044237,GO:0046434,GO:0071704,GO:1901575,GO:1902494,GO:1904176	4.7.1.1	ko:K05781,ko:K06163	ko00440,map00440		R10204	RC03078,RC03079	ko00000,ko00001,ko01000				Bacteria	1MVRN@1224,1RR70@1236,COG4107@1,COG4107@2	NA|NA|NA	P	phosphonate C-P lyase system protein PhnK
C1_03512	693444.D782_4172	5.6e-121	440.3	Gammaproteobacteria	phnL	GO:0005575,GO:0006793,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0019634,GO:0019637,GO:0019700,GO:0032991,GO:0044237,GO:0046434,GO:0061694,GO:0061695,GO:0071704,GO:1901575,GO:1902494,GO:1990234	2.7.8.37	ko:K05780	ko00440,map00440		R10185	RC00005,RC00063	ko00000,ko00001,ko01000				Bacteria	1MUPB@1224,1RS1I@1236,COG4778@1,COG4778@2	NA|NA|NA	P	phosphonate C-P lyase system protein PhnL
C1_03513	693444.D782_4173	1.5e-208	731.9	Gammaproteobacteria	phnM	GO:0006793,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0019634,GO:0019637,GO:0019700,GO:0044237,GO:0046434,GO:0071704,GO:1901575	3.6.1.63	ko:K06162	ko00440,map00440		R10186	RC00002	ko00000,ko00001,ko01000				Bacteria	1MV7H@1224,1RMR7@1236,COG3454@1,COG3454@2	NA|NA|NA	P	phosphonate metabolism protein PhnM
C1_03514	316407.85676847	2.2e-99	368.2	Gammaproteobacteria	phnN	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006015,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019200,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019634,GO:0019637,GO:0019674,GO:0019693,GO:0033863,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046391,GO:0046483,GO:0046496,GO:0046835,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.4.23	ko:K05774	ko00030,map00030		R06836	RC00002	ko00000,ko00001,ko01000			iAF1260.b4094,iB21_1397.B21_03926,iBWG_1329.BWG_3809,iECBD_1354.ECBD_3936,iECB_1328.ECB_03966,iECDH10B_1368.ECDH10B_4285,iECDH1ME8569_1439.ECDH1ME8569_3953,iECD_1391.ECD_03966,iEKO11_1354.EKO11_4224,iEcDH1_1363.EcDH1_3897,iEcolC_1368.EcolC_3932,iJO1366.b4094,iSSON_1240.SSON_4270,iUMNK88_1353.UMNK88_4960,iY75_1357.Y75_RS21315	Bacteria	1RGXZ@1224,1S3VA@1236,COG3709@1,COG3709@2	NA|NA|NA	F	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
C1_03515	316407.85676846	1.7e-78	298.5	Gammaproteobacteria	phnO	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006793,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019634,GO:0019637,GO:0033051,GO:0044237,GO:0044424,GO:0044464,GO:0071704,GO:1901564		ko:K09994	ko00440,map00440		R11479	RC00096	ko00000,ko00001,ko01000				Bacteria	1QEZN@1224,1S4IF@1236,COG0454@1,COG0456@2	NA|NA|NA	K	Escherichia coli uses a different mechanism of phosphonate catabolism where PhnO is not essential and seems to play a regulatory role
C1_03516	316407.85676845	7.3e-146	523.1	Gammaproteobacteria	phnP	GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0008081,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016787,GO:0016788,GO:0019634,GO:0019637,GO:0019700,GO:0030145,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046434,GO:0046872,GO:0046914,GO:0071704,GO:1901575	3.1.4.55	ko:K06167	ko00440,map00440		R10205	RC00296	ko00000,ko00001,ko01000				Bacteria	1P9QI@1224,1RQPE@1236,COG1235@1,COG1235@2	NA|NA|NA	S	Carbon-phosphorus lyase complex accessory protein
C1_03517	199310.c5097	4.1e-29	134.0	Escherichia	yjdP												Bacteria	1MYKJ@1224,1S5WZ@1236,2B3A4@1,31VYC@2,3XQ1D@561	NA|NA|NA		
C1_03518	316407.85676843	8.8e-21	106.3	Escherichia	rpiB	GO:0003674,GO:0003824,GO:0004751,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0008786,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019313,GO:0019314,GO:0019316,GO:0019318,GO:0019320,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0046367,GO:0071704,GO:1901575	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000			iECABU_c1320.ECABU_c46440,ic_1306.c5096	Bacteria	1RHBF@1224,1S3FD@1236,3XQ0J@561,COG0698@1,COG0698@2	NA|NA|NA	G	isomerase B
C1_03519	199310.c5089	0.0	1286.2	Escherichia	yjcS	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006082,GO:0006790,GO:0006805,GO:0008150,GO:0008152,GO:0008484,GO:0009410,GO:0009987,GO:0016787,GO:0016788,GO:0018741,GO:0018909,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0043436,GO:0044237,GO:0044281,GO:0044464,GO:0050896,GO:0051716,GO:0070887,GO:0071466,GO:0071704											Bacteria	1MU82@1224,1RMHR@1236,3XQEC@561,COG2015@1,COG2015@2	NA|NA|NA	Q	dodecyl sulfate metabolic process
C1_03520	469008.B21_04514	1.3e-39	168.7	Escherichia	ytcA												Bacteria	1NIF0@1224,1SGEJ@1236,2DR7E@1,33AJ8@2,3XR32@561	NA|NA|NA	S	Uncharacterised protein family
C1_03521	316407.85676834	2.5e-181	641.3	Escherichia	mdtN	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0015238,GO:0015546,GO:0015711,GO:0015849,GO:0015893,GO:0015906,GO:0016020,GO:0022857,GO:0033554,GO:0042221,GO:0042493,GO:0042886,GO:0042887,GO:0042891,GO:0042895,GO:0042908,GO:0042910,GO:0044464,GO:0045117,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:1901474,GO:1901682,GO:1902599		ko:K03543,ko:K15548,ko:K15549		M00701			ko00000,ko00002,ko02000	8.A.1.1,8.A.1.1.3,8.A.1.7.1			Bacteria	1MWG0@1224,1RP22@1236,3XMUQ@561,COG1566@1,COG1566@2	NA|NA|NA	V	Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride
C1_03522	316407.85676833	0.0	1322.8	Escherichia	mdtO	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015238,GO:0015546,GO:0015893,GO:0015906,GO:0016020,GO:0022857,GO:0042221,GO:0042493,GO:0042886,GO:0042887,GO:0042891,GO:0042895,GO:0042908,GO:0042910,GO:0044464,GO:0045117,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:1901474,GO:1901682,GO:1902599		ko:K15547					ko00000,ko02000	2.A.85.6.1			Bacteria	1R0HK@1224,1RQSH@1236,3XNXH@561,COG1289@1,COG1289@2	NA|NA|NA	U	Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride
C1_03523	198214.SF4140	5.5e-267	926.4	Gammaproteobacteria	mdtP	GO:0003674,GO:0005215,GO:0006810,GO:0006855,GO:0008150,GO:0015238,GO:0015546,GO:0015893,GO:0015906,GO:0022857,GO:0042221,GO:0042493,GO:0042886,GO:0042887,GO:0042891,GO:0042895,GO:0042908,GO:0042910,GO:0045117,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0072348,GO:1901474,GO:1901682,GO:1902599		ko:K15550					ko00000,ko02000	1.B.17.3.9			Bacteria	1MUZZ@1224,1RQEP@1236,COG1538@1,COG1538@2	NA|NA|NA	MU	RND efflux system, outer membrane lipoprotein
C1_03524	155864.EDL933_5420	1.7e-75	288.5	Escherichia	fdhF	GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009987,GO:0015942,GO:0015944,GO:0016491,GO:0016651,GO:0016999,GO:0017144,GO:0019752,GO:0030151,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704	1.17.1.10,1.17.1.9,1.17.99.7	ko:K00123,ko:K05299,ko:K22015	ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00630,map00680,map00720,map01100,map01120,map01200	M00377	R00134,R00519	RC02796	ko00000,ko00001,ko00002,ko01000			iHN637.CLJU_c06990	Bacteria	1QTZB@1224,1T1JA@1236,3XN7Y@561,COG3383@1,COG3383@2	NA|NA|NA	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C1_03525	316407.85676831	0.0	1144.0	Escherichia	fdhF	GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009987,GO:0015942,GO:0015944,GO:0016491,GO:0016651,GO:0016999,GO:0017144,GO:0019752,GO:0030151,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704	1.17.1.10,1.17.1.9,1.17.99.7	ko:K00123,ko:K05299,ko:K22015	ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00630,map00680,map00720,map01100,map01120,map01200	M00377	R00134,R00519	RC02796	ko00000,ko00001,ko00002,ko01000			iHN637.CLJU_c06990	Bacteria	1QTZB@1224,1T1JA@1236,3XN7Y@561,COG3383@1,COG3383@2	NA|NA|NA	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C1_03526	155864.EDL933_5419	1.8e-127	461.8	Escherichia	yjcO	GO:0003674,GO:0008047,GO:0008150,GO:0030234,GO:0043085,GO:0044093,GO:0050790,GO:0065007,GO:0065009,GO:0098772		ko:K07126					ko00000				Bacteria	1NEX5@1224,1RPRA@1236,3XNHQ@561,COG0790@1,COG0790@2	NA|NA|NA	S	enzyme activator activity
C1_03527	469008.B21_03909	3.7e-230	803.9	Escherichia	gltP	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0008150,GO:0015711,GO:0015849,GO:0016020,GO:0044464,GO:0046942,GO:0051179,GO:0051234,GO:0071702,GO:0071944		ko:K03309,ko:K11102,ko:K11103	ko02020,map02020				ko00000,ko00001,ko02000	2.A.23,2.A.23.1.1,2.A.23.1.2,2.A.23.1.3,2.A.23.1.6,2.A.23.1.7		iPC815.YPO0254,iSDY_1059.SDY_4548,iYO844.BSU10220	Bacteria	1MU0Q@1224,1RMEN@1236,3XNKQ@561,COG1301@1,COG1301@2	NA|NA|NA	C	Catalyzes the proton-dependent transport of glutamate and aspartate
C1_03528	198214.SF4136	5.6e-101	373.6	Gammaproteobacteria	nrfG	GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0018193,GO:0018198,GO:0018378,GO:0019538,GO:0022607,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0065003,GO:0071704,GO:0071840,GO:1901564		ko:K02200,ko:K04018					ko00000				Bacteria	1PJQ5@1224,1S1PY@1236,COG4235@1,COG4235@2	NA|NA|NA	O	Formate-dependent nitrite reductase complex
C1_03529	198214.SF4135	1e-63	249.2	Gammaproteobacteria	ccmH	GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0018193,GO:0018198,GO:0018378,GO:0019538,GO:0022607,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0065003,GO:0071704,GO:0071840,GO:1901564		ko:K02198,ko:K02200,ko:K04016,ko:K04017,ko:K04018			R05712	RC00176	ko00000,ko02000	9.B.14.1			Bacteria	1MZZ5@1224,1S9H1@1236,COG3088@1,COG3088@2	NA|NA|NA	P	subunit of a heme lyase
C1_03530	481805.EcolC_3953	4.5e-302	1043.1	Escherichia	ccmF	GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0018193,GO:0018198,GO:0018378,GO:0019538,GO:0022607,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:1901564		ko:K02198,ko:K04016			R05712	RC00176	ko00000,ko02000	9.B.14.1			Bacteria	1QU6F@1224,1RYR7@1236,3XMP3@561,COG1138@1,COG1138@2	NA|NA|NA	O	Cytochrome c-type biogenesis protein
C1_03531	481805.EcolC_3954	2.8e-171	607.8	Escherichia	nrfD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K04015,ko:K16294					ko00000,ko02000	5.A.3.5		iAPECO1_1312.APECO1_2382,iE2348C_1286.E2348C_4396,iECABU_c1320.ECABU_c46180,iECOK1_1307.ECOK1_4578,iECP_1309.ECP_4306,iECS88_1305.ECS88_4566,iLF82_1304.LF82_1523,iNRG857_1313.NRG857_20400,iUMN146_1321.UM146_20560,iUTI89_1310.UTI89_C4663,ic_1306.c5069	Bacteria	1MXQ9@1224,1RQ22@1236,3XNMB@561,COG3301@1,COG3301@2	NA|NA|NA	P	Polysulphide reductase, NrfD
C1_03532	155864.EDL933_5412	1.7e-130	471.9	Escherichia	nrfC	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016661,GO:0016662,GO:0042279,GO:0055114,GO:0098809		ko:K04014,ko:K08358	ko00920,ko01120,ko02020,map00920,map01120,map02020		R10150	RC03109	ko00000,ko00001,ko02000	5.A.3.10		iUMNK88_1353.UMNK88_4933	Bacteria	1NBNQ@1224,1RQJG@1236,3XMN4@561,COG0437@1,COG0437@2	NA|NA|NA	C	Probably involved in the transfer of electrons from the quinone pool to the type-c cytochromes
C1_03533	481805.EcolC_3956	2.4e-109	401.4	Escherichia	nrfB	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0016661,GO:0016662,GO:0019645,GO:0020037,GO:0022900,GO:0022904,GO:0030288,GO:0030313,GO:0031975,GO:0042279,GO:0042597,GO:0044237,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0097159,GO:0098809,GO:1901363		ko:K04013					ko00000			iAF1260.b4071,iB21_1397.B21_03903,iBWG_1329.BWG_3785,iE2348C_1286.E2348C_4394,iEC55989_1330.EC55989_4566,iECABU_c1320.ECABU_c46160,iECBD_1354.ECBD_3961,iECB_1328.ECB_03943,iECDH1ME8569_1439.ECDH1ME8569_3929,iECD_1391.ECD_03943,iECED1_1282.ECED1_4799,iECH74115_1262.ECH74115_5576,iECO111_1330.ECO111_4947,iECO26_1355.ECO26_5189,iECP_1309.ECP_4304,iECSE_1348.ECSE_4366,iECSP_1301.ECSP_5168,iECW_1372.ECW_m4437,iEKO11_1354.EKO11_4249,iETEC_1333.ETEC_4381,iEcDH1_1363.EcDH1_3921,iEcE24377_1341.EcE24377A_4627,iEcHS_1320.EcHS_A4316,iJO1366.b4071,iLF82_1304.LF82_1521,iNRG857_1313.NRG857_20390,iUMNK88_1353.UMNK88_4932,iWFL_1372.ECW_m4437,iY75_1357.Y75_RS21185	Bacteria	1R4W9@1224,1RR9K@1236,3XNIN@561,COG3303@1,COG3303@2	NA|NA|NA	C	Plays a role in nitrite reduction
C1_03534	155864.EDL933_5410	2.8e-287	993.8	Escherichia	nrfA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006091,GO:0006807,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0016661,GO:0016662,GO:0016966,GO:0019645,GO:0020037,GO:0022900,GO:0022904,GO:0030288,GO:0030313,GO:0031975,GO:0042279,GO:0042597,GO:0044237,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0097159,GO:0098809,GO:1901363	1.7.2.2	ko:K03385	ko00910,ko01120,ko05132,map00910,map01120,map05132	M00530	R05712	RC00176	ko00000,ko00001,ko00002,ko01000			iZ_1308.Z5669	Bacteria	1MVJT@1224,1RQD1@1236,3XME8@561,COG3303@1,COG3303@2	NA|NA|NA	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
C1_03535	316407.85676821	0.0	1350.1	Escherichia	acsA	GO:0003674,GO:0003824,GO:0003987,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006083,GO:0006084,GO:0006085,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006473,GO:0006476,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016054,GO:0016405,GO:0016787,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017001,GO:0017144,GO:0018130,GO:0018193,GO:0018205,GO:0018394,GO:0019213,GO:0019427,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033558,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034421,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0035601,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0043687,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0045733,GO:0046390,GO:0046395,GO:0046483,GO:0050218,GO:0051186,GO:0051188,GO:0055086,GO:0071616,GO:0071704,GO:0072329,GO:0072521,GO:0072522,GO:0090407,GO:0098732,GO:0140096,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004			iE2348C_1286.E2348C_4392,iYL1228.KPN_04478	Bacteria	1MUF5@1224,1RMNZ@1236,3XNZN@561,COG0365@1,COG0365@2	NA|NA|NA	F	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl- adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1_03536	198214.SF4128	6.2e-51	206.5	Gammaproteobacteria	yjcH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1MZF3@1224,1SCCK@1236,COG3162@1,COG3162@2	NA|NA|NA	S	Membrane
C1_03537	316407.85676819	3.7e-296	1023.5	Escherichia	actP	GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006846,GO:0006847,GO:0006855,GO:0008028,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015103,GO:0015123,GO:0015238,GO:0015318,GO:0015654,GO:0015698,GO:0015710,GO:0015711,GO:0015718,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0035433,GO:0042221,GO:0042493,GO:0042891,GO:0042895,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098656,GO:1903825,GO:1905039		ko:K14393					ko00000,ko02000	2.A.21.7		iB21_1397.B21_03899,iECBD_1354.ECBD_3965,iECD_1391.ECD_03939	Bacteria	1MVJ8@1224,1RN0R@1236,3XMJ5@561,COG4147@1,COG4147@2	NA|NA|NA	P	Cation acetate symporter ActP
C1_03538	198214.SF4126	2e-183	648.7	Gammaproteobacteria	yjcF												Bacteria	1QGYJ@1224,1SJA2@1236,COG1357@1,COG1357@2	NA|NA|NA	S	Pentapeptide repeats (9 copies)
C1_03539	155864.EDL933_5405	1.9e-295	1021.1	Escherichia	yjcE	GO:0003674,GO:0005215,GO:0005451,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006814,GO:0006873,GO:0006885,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015079,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015386,GO:0015491,GO:0015672,GO:0016020,GO:0019725,GO:0022804,GO:0022821,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030004,GO:0030641,GO:0034220,GO:0035725,GO:0042592,GO:0044464,GO:0046873,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0051453,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098657,GO:0098659,GO:0098660,GO:0098662,GO:0098719,GO:0098739,GO:0098771,GO:0099516,GO:0099587,GO:1902600		ko:K03316					ko00000	2.A.36			Bacteria	1MW5T@1224,1RPH6@1236,3XN4E@561,COG0025@1,COG0025@2	NA|NA|NA	P	sodium ion import across plasma membrane
C1_03540	155864.EDL933_5403	3.3e-234	817.4	Escherichia	yjcD	GO:0003674,GO:0005215,GO:0005345,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006863,GO:0008150,GO:0015205,GO:0015208,GO:0015851,GO:0015854,GO:0016020,GO:0022857,GO:0035344,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072530,GO:0098657,GO:0098710,GO:0098739,GO:1903716,GO:1904823		ko:K06901					ko00000,ko02000	2.A.1.40		iECH74115_1262.ECH74115_5145,iECSP_1301.ECSP_4762,iECs_1301.ECs4651,iG2583_1286.G2583_4505,iZ_1308.Z5209	Bacteria	1MUV0@1224,1RMBE@1236,3XNSU@561,COG2252@1,COG2252@2	NA|NA|NA	S	High-affinity transporter for guanine and hypoxanthine
C1_03541	155864.EDL933_5401	4.5e-82	310.5	Escherichia	soxR	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0044424,GO:0044464,GO:0048037,GO:0050896,GO:0051536,GO:0051537,GO:0051540		ko:K13639					ko00000,ko03000				Bacteria	1RH2U@1224,1S6M0@1236,3XM4P@561,COG0789@1,COG0789@2	NA|NA|NA	K	Activates the transcription of the soxS gene which itself controls the superoxide response regulon. SoxR contains a 2Fe-2S iron-sulfur cluster that may act as a redox sensor system that recognizes superoxide. The variable redox state of the Fe-S cluster is employed in vivo to modulate the transcriptional activity of SoxR in response to specific types of oxidative stress. Upon reduction of 2Fe-2S cluster, SoxR reversibly loses its transcriptional activity, but retains its DNA binding affinity
C1_03542	155864.EDL933_5400	2.5e-55	221.1	Escherichia	soxS	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0001098,GO:0001108,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006081,GO:0006082,GO:0006089,GO:0006355,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009438,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019172,GO:0019219,GO:0019222,GO:0019243,GO:0019249,GO:0019752,GO:0031323,GO:0031326,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0043565,GO:0044212,GO:0044237,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044464,GO:0046185,GO:0046394,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0051596,GO:0060255,GO:0061727,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:0097159,GO:1901363,GO:1901575,GO:1901576,GO:1901615,GO:1901617,GO:1903506,GO:1990837,GO:2000112,GO:2001141		ko:K05804,ko:K13631		M00647,M00767			ko00000,ko00002,ko03000,ko03036				Bacteria	1QV3Z@1224,1T27F@1236,3XPPU@561,COG2207@1,COG2207@2	NA|NA|NA	K	Transcriptional activator of the superoxide response regulon of E.coli that includes at least 10 genes such as sodA, nfo, zwf and micF. Binds the DNA sequence 5'-GCACN(7)CAA-3'. It also facilitates the subsequent binding of RNA polymerase to the micF and the nfo promoters
C1_03543	316407.85676813	3.2e-305	1053.5	Escherichia	yjcC	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008081,GO:0016020,GO:0016787,GO:0016788,GO:0042578,GO:0044464,GO:0071111,GO:0071944	3.1.4.52	ko:K21090	ko02026,map02026				ko00000,ko00001,ko01000				Bacteria	1MVTH@1224,1RMDP@1236,3XNKJ@561,COG4943@1,COG4943@2	NA|NA|NA	T	May function as a c-di-GMP phosphodiesterase. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria. Overexpression reduces biofilm formation
C1_03544	155864.EDL933_5398	2.5e-43	181.0	Escherichia	yjcB												Bacteria	1RIMH@1224,1S71K@1236,2CRMS@1,32SPC@2,3XPTY@561	NA|NA|NA	S	Family of unknown function
C1_03545	155864.EDL933_5397	1.2e-81	309.3	Escherichia	ssb	GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006298,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008047,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030234,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0042802,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:0098772,GO:1901360,GO:1901363,GO:1901576		ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440				ko00000,ko00001,ko03029,ko03032,ko03400				Bacteria	1RCWT@1224,1S3WP@1236,3XMYI@561,COG0629@1,COG0629@2	NA|NA|NA	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
C1_03546	198214.SF4146	0.0	1878.6	Gammaproteobacteria	uvrA	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1905347,GO:1905348,GO:1990391		ko:K03701	ko03420,map03420				ko00000,ko00001,ko03400				Bacteria	1MW0W@1224,1RMS9@1236,COG0178@1,COG0178@2	NA|NA|NA	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
C1_03547	155864.EDL933_5395	1.4e-59	235.3	Escherichia	yjbR												Bacteria	1RD85@1224,1S3PR@1236,3XPRK@561,COG2315@1,COG2315@2	NA|NA|NA	S	YjbR
C1_03548	155864.EDL933_5394	5.7e-76	290.0	Escherichia	yjbQ												Bacteria	1RH13@1224,1S3VP@1236,3XNQ9@561,COG0432@1,COG0432@2	NA|NA|NA	S	Uncharacterised protein family UPF0047
C1_03549	198214.SF4149	1.7e-133	481.9	Gammaproteobacteria	aphA	GO:0003674,GO:0003824,GO:0003993,GO:0004647,GO:0005488,GO:0005575,GO:0005623,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0030288,GO:0030313,GO:0031975,GO:0042578,GO:0042597,GO:0044237,GO:0044464,GO:0048037	3.1.3.2	ko:K03788	ko00740,ko01100,map00740,map01100		R00548	RC00017	ko00000,ko00001,ko01000			iECIAI39_1322.ECIAI39_4476,iYL1228.KPN_04442	Bacteria	1PRRA@1224,1RP0N@1236,COG3700@1,COG3700@2	NA|NA|NA	S	Belongs to the class B bacterial acid phosphatase family
C1_03550	481805.EcolC_3973	1.4e-57	229.2	Gammaproteobacteria													Bacteria	1NV8P@1224,1SNIK@1236,2DV4G@1,33U04@2	NA|NA|NA		
C1_03551	469008.B21_03886	8.6e-226	789.3	Escherichia	tyrB	GO:0003674,GO:0003824,GO:0004838,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006531,GO:0006532,GO:0006551,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0008793,GO:0009058,GO:0009066,GO:0009067,GO:0009072,GO:0009073,GO:0009081,GO:0009082,GO:0009094,GO:0009095,GO:0009098,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0019292,GO:0019438,GO:0019752,GO:0019842,GO:0030170,GO:0033585,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050048,GO:0050662,GO:0070279,GO:0070547,GO:0071704,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223	2.6.1.1,2.6.1.57	ko:K00813,ko:K00832	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	M00024,M00025,M00034,M00040	R00355,R00694,R00734,R00896,R01731,R02433,R02619,R05052,R07396,R10845	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007			iECED1_1282.ECED1_4768,iECSE_1348.ECSE_4347,iJN746.PP_3590,iLF82_1304.LF82_2339,iNRG857_1313.NRG857_20250,iSFxv_1172.SFxv_1000,iUTI89_1310.UTI89_C4629	Bacteria	1MUT0@1224,1RN02@1236,3XMH8@561,COG1448@1,COG1448@2	NA|NA|NA	E	Broad-specificity enzyme that catalyzes the transamination of 2-ketoisocaproate, p-hydroxyphenylpyruvate, and phenylpyruvate to yield leucine, tyrosine, and phenylalanine, respectively. In vitro, is able to catalyze the conversion of beta-methyl phenylpyruvate to the nonproteinogenic amino acid (2S,3S)-beta-methyl-phenylalanine, a building block of the antibiotic mannopeptimycin produced by Streptomyces hygroscopicus NRRL3085
C1_03552	198214.SF4152	2.6e-205	721.1	Gammaproteobacteria	alr	GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0006022,GO:0006023,GO:0006024,GO:0006082,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008784,GO:0009058,GO:0009059,GO:0009078,GO:0009079,GO:0009252,GO:0009273,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0019842,GO:0030170,GO:0030203,GO:0030632,GO:0034645,GO:0036094,GO:0036361,GO:0040007,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044281,GO:0044283,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0047661,GO:0048037,GO:0050662,GO:0070279,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502		R00401	RC00285	ko00000,ko00001,ko01000,ko01011			iEC55989_1330.EC55989_1285,iECIAI39_1322.ECIAI39_1880,iECO103_1326.ECO103_1292,iECO26_1355.ECO26_1703,iECSE_1348.ECSE_1238,iECUMN_1333.ECUMN_1479,iECW_1372.ECW_m1275,iEKO11_1354.EKO11_2666,iEcE24377_1341.EcE24377A_1335,iPC815.YPO0321,iSBO_1134.SBO_4064,iSbBS512_1146.SbBS512_E4542,iWFL_1372.ECW_m1275,iYL1228.KPN_04440	Bacteria	1MV0Q@1224,1RM8U@1236,COG0787@1,COG0787@2	NA|NA|NA	E	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C1_03553	198214.SF4154	1.6e-263	914.8	Gammaproteobacteria	dnaB	GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112				ko00000,ko00001,ko01000,ko03032				Bacteria	1MUG9@1224,1RPM2@1236,COG0305@1,COG0305@2	NA|NA|NA	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins
C1_03554	155864.EDL933_5387	1.7e-179	635.2	Escherichia	qor	GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003960,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016651,GO:0016655,GO:0017091,GO:0033554,GO:0034599,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097159,GO:1901363	1.6.5.5	ko:K00344					ko00000,ko01000				Bacteria	1MWBD@1224,1RPCQ@1236,3XNAN@561,COG0604@1,COG0604@2	NA|NA|NA	C	Quinone oxidoreductase
C1_03555	198214.SF4155	1.4e-18	98.6	Gammaproteobacteria	pspG	GO:0006950,GO:0008150,GO:0009271,GO:0009605,GO:0009607,GO:0009615,GO:0043207,GO:0050896,GO:0051704,GO:0051707,GO:0098586											Bacteria	1N8FV@1224,1SCBJ@1236,2E8D0@1,332RI@2	NA|NA|NA	S	Phage Shock Protein G
C1_03556	155864.EDL933_5385	3.4e-202	710.7	Escherichia	dusA	GO:0000049,GO:0000166,GO:0002943,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010181,GO:0010467,GO:0016070,GO:0016491,GO:0016627,GO:0017150,GO:0032553,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050662,GO:0055114,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363		ko:K05539,ko:K05540					ko00000,ko01000,ko03016				Bacteria	1MUY1@1224,1RN28@1236,3XP3Q@561,COG0042@1,COG0042@2	NA|NA|NA	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs
C1_03557	316407.85676800	3.3e-130	471.5	Gammaproteobacteria	yjbM												Bacteria	1NTW1@1224,1SJIW@1236,2DUZ3@1,33T3G@2	NA|NA|NA	S	Protein of unknown function (DUF2713)
C1_03558	198214.SF4159	1.8e-92	345.1	Gammaproteobacteria	zur	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010043,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0046872,GO:0046914,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K02076,ko:K03711,ko:K09823	ko02024,map02024				ko00000,ko00001,ko03000				Bacteria	1MZIW@1224,1S5ZI@1236,COG0735@1,COG0735@2	NA|NA|NA	P	belongs to the Fur family
C1_03559	155864.EDL933_5382	2.3e-33	147.5	Escherichia	yjbJ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Bacteria	1N6X4@1224,1SDHP@1236,3XQ1R@561,COG3237@1,COG3237@2	NA|NA|NA	S	Belongs to the UPF0337 (CsbD) family
C1_03560	198214.SF4161	4.3e-234	817.0	Gammaproteobacteria	dinF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03327					ko00000,ko02000	2.A.66.1			Bacteria	1MV6B@1224,1RPGF@1236,COG0534@1,COG0534@2	NA|NA|NA	V	COG0534 Na -driven multidrug efflux pump
C1_03561	1440052.EAKF1_ch1871c	1.1e-107	396.0	Escherichia	lexA	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006282,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032774,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0071704,GO:0080090,GO:0080134,GO:0080135,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001020,GO:2001141	3.4.21.88	ko:K01356		M00729			ko00000,ko00002,ko01000,ko01002,ko03400				Bacteria	1MW80@1224,1RMXF@1236,3XP1V@561,COG1974@1,COG1974@2	NA|NA|NA	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C1_03562	155864.EDL933_5379	1.1e-57	229.2	Escherichia	dgkA	GO:0003674,GO:0003824,GO:0004143,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006644,GO:0006650,GO:0006654,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0045017,GO:0046473,GO:0046474,GO:0046486,GO:0050896,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.7.1.107	ko:K00901	ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00561,map00564,map01100,map01110,map04070,map04072,map05231		R02240	RC00002,RC00017	ko00000,ko00001,ko01000				Bacteria	1MZ3Q@1224,1S92I@1236,3XPP6@561,COG0818@1,COG0818@2	NA|NA|NA	M	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C1_03563	199310.c5011	0.0	1601.3	Escherichia	plsB	GO:0003674,GO:0003824,GO:0004366,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006629,GO:0006631,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0019752,GO:0031224,GO:0031226,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.3.1.15	ko:K00631	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004			iECs_1301.ECs5024,iG2583_1286.G2583_4866	Bacteria	1MWZ6@1224,1RM7K@1236,3XNFZ@561,COG2937@1,COG2937@2	NA|NA|NA	I	Belongs to the GPAT DAPAT family
C1_03564	155864.EDL933_5377	1.8e-148	531.9	Escherichia	ubiA	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008412,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006			iZ_1308.Z5639	Bacteria	1MV4Q@1224,1RMZ1@1236,3XNZT@561,COG0382@1,COG0382@2	NA|NA|NA	H	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C1_03565	198214.SF4166	5.9e-88	330.1	Gammaproteobacteria	ubiC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008813,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	4.1.3.40	ko:K03181	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R01302	RC00491,RC02148	ko00000,ko00001,ko00002,ko01000			iZ_1308.Z5638	Bacteria	1N8BF@1224,1S6A0@1236,COG3161@1,COG3161@2	NA|NA|NA	H	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway
C1_03566	316407.85676790	3.5e-220	770.8	Bacteria	yjbI												Bacteria	COG1357@1,COG1357@2	NA|NA|NA	S	protein homooligomerization
C1_03567	155864.EDL933_5375	1.5e-18	98.2	Bacteria	yjbI												Bacteria	COG1357@1,COG1357@2	NA|NA|NA	S	protein homooligomerization
C1_03569	481805.EcolC_3992	1.9e-164	585.1	Escherichia	malM	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464		ko:K05775					ko00000				Bacteria	1MY1F@1224,1RQ3A@1236,2C19D@1,2Z7PA@2,3XMDZ@561	NA|NA|NA	S	Maltose operon periplasmic
C1_03570	481805.EcolC_3993	8.6e-267	925.6	Escherichia	lamB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0006950,GO:0006974,GO:0008150,GO:0008643,GO:0009279,GO:0009987,GO:0015144,GO:0015159,GO:0015267,GO:0015288,GO:0015774,GO:0016020,GO:0016021,GO:0019867,GO:0022803,GO:0022829,GO:0022857,GO:0022884,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031975,GO:0032991,GO:0033036,GO:0033037,GO:0033554,GO:0034219,GO:0042956,GO:0042958,GO:0044425,GO:0044462,GO:0044464,GO:0045203,GO:0046930,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071702,GO:0071944,GO:0098796		ko:K02024,ko:K10124					ko00000,ko02000	1.B.3.1.1,1.B.3.1.3		iEC55989_1330.EC55989_4527,iYL1228.KPN_04425	Bacteria	1MX77@1224,1RPMF@1236,3XP8N@561,COG4580@1,COG4580@2	NA|NA|NA	M	Involved in the transport of maltose and maltodextrins
C1_03571	155864.EDL933_5372	2.2e-207	728.0	Escherichia	malK	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005363,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008134,GO:0008144,GO:0008150,GO:0008643,GO:0009898,GO:0015144,GO:0015154,GO:0015157,GO:0015399,GO:0015405,GO:0015422,GO:0015423,GO:0015766,GO:0015768,GO:0015772,GO:0015774,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019897,GO:0019898,GO:0022804,GO:0022857,GO:0030554,GO:0031224,GO:0031226,GO:0031234,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033037,GO:0033613,GO:0034219,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042956,GO:0043167,GO:0043168,GO:0043190,GO:0043211,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0097159,GO:0097367,GO:0098533,GO:0098552,GO:0098562,GO:0098796,GO:0098797,GO:1901265,GO:1901363,GO:1902494,GO:1902495,GO:1904949,GO:1990060,GO:1990351		ko:K10111	ko02010,map02010	M00194,M00200,M00204,M00207,M00491			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1		iYL1228.KPN_04424,ic_1306.c5005	Bacteria	1MU3I@1224,1RM9E@1236,3XN2Y@561,COG3842@1,COG3842@2	NA|NA|NA	P	Part of the ABC transporter complex MalEFGK involved in maltose maltodextrin import. Responsible for energy coupling to the transport system
C1_03573	155864.EDL933_5371	2e-227	794.7	Escherichia	malE	GO:0003674,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006928,GO:0006935,GO:0006950,GO:0006974,GO:0008150,GO:0008643,GO:0009593,GO:0009605,GO:0009730,GO:0009743,GO:0009987,GO:0010033,GO:0015766,GO:0015768,GO:0015772,GO:0015774,GO:0016020,GO:0016021,GO:0016477,GO:0030246,GO:0030288,GO:0030313,GO:0031224,GO:0031975,GO:0032991,GO:0033036,GO:0033037,GO:0033554,GO:0034285,GO:0034286,GO:0034288,GO:0034289,GO:0040011,GO:0042221,GO:0042330,GO:0042597,GO:0042956,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0048030,GO:0048870,GO:0050896,GO:0051179,GO:0051234,GO:0051606,GO:0051674,GO:0051716,GO:0055052,GO:0060326,GO:0070492,GO:0070887,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901700,GO:1901982,GO:1902494,GO:1902495,GO:1904949,GO:1990351		ko:K10108	ko02010,ko02030,map02010,map02030	M00194			ko00000,ko00001,ko00002,ko02000	3.A.1.1.1,3.A.1.1.22		iECUMN_1333.ECUMN_4568,iLJ478.TM1204	Bacteria	1N9AE@1224,1RN4E@1236,3XMUV@561,COG2182@1,COG2182@2	NA|NA|NA	P	Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides
C1_03574	316407.85676785	1.2e-296	1025.0	Escherichia	malF	GO:0001406,GO:0001407,GO:0003674,GO:0003824,GO:0005215,GO:0005363,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006950,GO:0006974,GO:0008150,GO:0008509,GO:0008514,GO:0008643,GO:0009987,GO:0015075,GO:0015144,GO:0015154,GO:0015157,GO:0015169,GO:0015399,GO:0015405,GO:0015422,GO:0015423,GO:0015605,GO:0015711,GO:0015748,GO:0015766,GO:0015768,GO:0015772,GO:0015774,GO:0015794,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033037,GO:0033554,GO:0034219,GO:0034220,GO:0042623,GO:0042626,GO:0042956,GO:0043190,GO:0043211,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055052,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098656,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990060,GO:1990351		ko:K02025,ko:K05814,ko:K10109,ko:K15771	ko02010,map02010	M00194,M00198,M00207,M00491			ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.1,3.A.1.1.16,3.A.1.1.2,3.A.1.1.22,3.A.1.1.3		iSFxv_1172.SFxv_3786,iZ_1308.Z5631	Bacteria	1MXKR@1224,1RN6B@1236,3XP8S@561,COG1175@1,COG1175@2	NA|NA|NA	G	probably responsible for the translocation of the substrate across the membrane
C1_03575	155864.EDL933_5369	2.3e-159	568.2	Escherichia	malG	GO:0003674,GO:0003824,GO:0005215,GO:0005363,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015154,GO:0015157,GO:0015399,GO:0015405,GO:0015422,GO:0015423,GO:0015766,GO:0015768,GO:0015772,GO:0015774,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033037,GO:0034219,GO:0042623,GO:0042626,GO:0042956,GO:0043190,GO:0043211,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990060,GO:1990351		ko:K10110,ko:K15772	ko02010,map02010	M00194,M00491			ko00000,ko00001,ko00002,ko02000	3.A.1.1.1,3.A.1.1.16,3.A.1.1.2,3.A.1.1.22		iLJ478.TM1202,iSSON_1240.SSON_4210,iYL1228.KPN_04421	Bacteria	1QA3Z@1224,1RQ00@1236,3XNEJ@561,COG3833@1,COG3833@2	NA|NA|NA	P	probably responsible for the translocation of the substrate across the membrane
C1_03576	155864.EDL933_5368	2.7e-277	960.7	Escherichia	xylE	GO:0003674,GO:0005215,GO:0005351,GO:0005402,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0008643,GO:0015075,GO:0015077,GO:0015078,GO:0015144,GO:0015145,GO:0015146,GO:0015148,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015519,GO:0015672,GO:0015749,GO:0015750,GO:0015753,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034219,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600		ko:K02100,ko:K08137,ko:K08138					ko00000,ko02000	2.A.1.1.1,2.A.1.1.2,2.A.1.1.3		iAF1260.b2841,iBWG_1329.BWG_2577,iEC55989_1330.EC55989_3118,iECDH10B_1368.ECDH10B_3013,iECDH1ME8569_1439.ECDH1ME8569_2748,iECDH1ME8569_1439.EcDH1_0849,iECIAI1_1343.ECIAI1_2951,iECIAI1_1343.ECIAI1_4259,iECIAI39_1322.ECIAI39_3261,iECO111_1330.ECO111_3570,iECO26_1355.ECO26_3914,iECSE_1348.ECSE_3098,iECSE_1348.ECSE_4322,iECUMN_1333.ECUMN_3169,iECW_1372.ECW_m3086,iECs_1301.ECs3698,iEKO11_1354.EKO11_0899,iETEC_1333.ETEC_3028,iEcDH1_1363.EcDH1_0849,iEcE24377_1341.EcE24377A_3162,iEcHS_1320.EcHS_A2988,iG2583_1286.G2583_3498,iG2583_1286.G2583_3602,iJO1366.b2841,iJR904.b2841,iSSON_1240.SSON_3001,iUMNK88_1353.UMNK88_3526,iWFL_1372.ECW_m3086,iY75_1357.Y75_RS14785,iZ_1308.Z4161	Bacteria	1MVKJ@1224,1RMHJ@1236,3XN94@561,COG0477@1,COG0477@2,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
C1_03577	198214.SF4175	7.6e-65	253.1	Gammaproteobacteria	psiE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K13256					ko00000				Bacteria	1RD8R@1224,1S4FE@1236,COG3223@1,COG3223@2	NA|NA|NA	S	Protein PsiE homolog
C1_03578	481805.EcolC_4001	0.0	1402.9	Escherichia	yjbH	GO:0000271,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016051,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0045226,GO:0046379,GO:0071704,GO:1901576		ko:K07277					ko00000,ko02000,ko03029	1.B.33			Bacteria	1MX3H@1224,1RQKV@1236,3XMA1@561,COG4775@1,COG4775@2	NA|NA|NA	M	extracellular polysaccharide metabolic process
C1_03579	198214.SF4177	1.7e-131	475.3	Gammaproteobacteria	yjbG	GO:0000271,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016051,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0045226,GO:0046379,GO:0071704,GO:1901576											Bacteria	1QUFK@1224,1T1X9@1236,29T7B@1,2ZAUX@2	NA|NA|NA	S	extracellular polysaccharide metabolic process
C1_03580	198214.SF4178	9.2e-118	429.5	Gammaproteobacteria	yjbF	GO:0000271,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016051,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0045226,GO:0046379,GO:0071704,GO:1901576											Bacteria	1N1VT@1224,1RMP6@1236,28M8B@1,2ZAMG@2	NA|NA|NA	S	Lipoprotein
C1_03581	155864.EDL933_5361	5.9e-09	66.6	Escherichia	yjbE	GO:0000271,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016051,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0045226,GO:0046379,GO:0071704,GO:1901576											Bacteria	1MZI0@1224,1SAZ2@1236,2CXU3@1,32T2M@2,3XQ1Q@561	NA|NA|NA	S	extracellular polysaccharide metabolic process
C1_03582	155864.EDL933_5360	0.0	1111.3	Escherichia	pgi	GO:0003674,GO:0003824,GO:0004347,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033554,GO:0034404,GO:0034599,GO:0034641,GO:0034654,GO:0034655,GO:0042221,GO:0042802,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0055086,GO:0070887,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147			iEcSMS35_1347.EcSMS35_4486	Bacteria	1MUFP@1224,1RNIT@1236,3XNB8@561,COG0166@1,COG0166@2	NA|NA|NA	F	Belongs to the GPI family
C1_03583	199310.c4990	4.6e-244	850.1	Escherichia	lysC	GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009085,GO:0009089,GO:0009090,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.3,2.7.2.4,4.1.1.20	ko:K00928,ko:K12524,ko:K12525,ko:K12526	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00451,R00480,R01773,R01775	RC00002,RC00043,RC00087,RC00299	ko00000,ko00001,ko00002,ko01000			iECED1_1282.ECED1_4739,iPC815.YPO3719,iUMNK88_1353.UMNK88_4778	Bacteria	1MW3H@1224,1RMJ6@1236,3XMQD@561,COG0527@1,COG0527@2	NA|NA|NA	E	Belongs to the aspartokinase family
C1_03584	1028805.GGC_1143	1e-45	190.7	Gammaproteobacteria	bepH		2.7.1.176	ko:K04095,ko:K16214					ko00000,ko01000,ko02048,ko03036				Bacteria	1NIDK@1224,1SNKG@1236,COG2184@1,COG2184@2,COG4185@1,COG4185@2	NA|NA|NA	D	zeta toxin
C1_03585	754331.AEME01000001_gene2256	2.4e-133	481.5	Gammaproteobacteria	ycgL			ko:K07074					ko00000				Bacteria	1MYFT@1224,1RY9F@1236,COG3541@1,COG3541@2	NA|NA|NA	S	nucleotidyltransferase
C1_03586	1114922.CIFAM_09_00280	1.1e-179	636.0	Citrobacter													Bacteria	1MWMD@1224,1RNGH@1236,3WWN1@544,COG0330@1,COG0330@2	NA|NA|NA	O	prohibitin homologues
C1_03587	1440052.EAKF1_ch1890	1.6e-39	168.3	Escherichia	yjbD												Bacteria	1RHBT@1224,1S7BQ@1236,2B37U@1,31VVV@2,3XQ1P@561	NA|NA|NA	S	YjbD family (DUF3811)
C1_03588	481805.EcolC_4008	9.2e-161	572.8	Escherichia	rluF	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.19,5.4.99.21,5.4.99.22	ko:K06178,ko:K06182,ko:K06183					ko00000,ko01000,ko03009				Bacteria	1MXQE@1224,1RMC7@1236,3XNF8@561,COG1187@1,COG1187@2	NA|NA|NA	J	Catalyzes the synthesis of pseudouridine from uracil- 2604 in 23S ribosomal RNA
C1_03589	155864.EDL933_5348	2.4e-127	461.5	Escherichia	pepE	GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:0140096,GO:1901564	3.4.13.21	ko:K05995					ko00000,ko01000,ko01002				Bacteria	1NBN5@1224,1RYUM@1236,3XMR5@561,COG3340@1,COG3340@2	NA|NA|NA	E	Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids
C1_03590	198214.SF4086	2.9e-285	987.3	Gammaproteobacteria	yjbB	GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0022804,GO:0022857,GO:0034220,GO:0035435,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661		ko:K03324					ko00000,ko02000	2.A.58.2			Bacteria	1MUDE@1224,1RNMM@1236,COG1283@1,COG1283@2	NA|NA|NA	P	Na Pi-Cotransporter
C1_03591	316407.85676771	0.0	2437.9	Escherichia	metH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000			iECO103_1326.ECO103_4764,iECUMN_1333.ECUMN_4545	Bacteria	1MV6G@1224,1RMYD@1236,3XM8P@561,COG0646@1,COG0646@2,COG1410@1,COG1410@2	NA|NA|NA	H	Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate
C1_03592	155864.EDL933_5345	1.1e-150	539.3	Escherichia	iclR	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K10973,ko:K13641					ko00000,ko03000				Bacteria	1MUNW@1224,1RY9N@1236,3XM44@561,COG1414@1,COG1414@2	NA|NA|NA	K	Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyruvate enhances promoter binding by stabilizing the tetrameric form
C1_03593	481805.EcolC_4013	2.2e-229	801.2	Gammaproteobacteria	arpA			ko:K06867					ko00000				Bacteria	1QWC1@1224,1T2TD@1236,32YAJ@2,COG0666@1	NA|NA|NA	S	Corresponds to locus_tag
C1_03594	481805.EcolC_4013	4.5e-13	80.9	Gammaproteobacteria	arpA			ko:K06867					ko00000				Bacteria	1QWC1@1224,1T2TD@1236,32YAJ@2,COG0666@1	NA|NA|NA	S	Corresponds to locus_tag
C1_03595	316407.85676768	0.0	1186.0	Escherichia	aceK	GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0004721,GO:0004722,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008772,GO:0009060,GO:0009987,GO:0015980,GO:0016208,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0016999,GO:0017076,GO:0017144,GO:0018105,GO:0018193,GO:0018209,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0036211,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044267,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046487,GO:0050790,GO:0055114,GO:0065007,GO:0065009,GO:0070262,GO:0071704,GO:0072350,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	2.7.11.5	ko:K00906					ko00000,ko01000				Bacteria	1MVRB@1224,1RMC2@1236,3XM4V@561,COG4579@1,COG4579@2	NA|NA|NA	F	Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation
C1_03596	316407.85676767	2.5e-247	860.9	Escherichia	aceA	GO:0001101,GO:0001666,GO:0003674,GO:0003824,GO:0004451,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006081,GO:0006082,GO:0006097,GO:0006102,GO:0006950,GO:0008150,GO:0008152,GO:0009268,GO:0009405,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0010033,GO:0010034,GO:0010447,GO:0016020,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0019899,GO:0032787,GO:0033554,GO:0033993,GO:0035375,GO:0036293,GO:0036294,GO:0042221,GO:0043167,GO:0043169,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046421,GO:0046487,GO:0046677,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0070482,GO:0070542,GO:0070887,GO:0071453,GO:0071456,GO:0071704,GO:0071944,GO:0072350,GO:0075136,GO:0075141,GO:1901700	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000			e_coli_core.b4015,iAF1260.b4015,iB21_1397.B21_03847,iBWG_1329.BWG_3671,iE2348C_1286.E2348C_4318,iEC042_1314.EC042_4377,iEC55989_1330.EC55989_4500,iECABU_c1320.ECABU_c45310,iECBD_1354.ECBD_4022,iECB_1328.ECB_03887,iECDH10B_1368.ECDH10B_4204,iECDH1ME8569_1439.ECDH1ME8569_3871,iECD_1391.ECD_03887,iECED1_1282.ECED1_4722,iECIAI1_1343.ECIAI1_4235,iECIAI39_1322.ECIAI39_4401,iECNA114_1301.ECNA114_4164,iECO103_1326.ECO103_4759,iECO111_1330.ECO111_4827,iECO26_1355.ECO26_5119,iECP_1309.ECP_4225,iECSE_1348.ECSE_4300,iECSF_1327.ECSF_3865,iECUMN_1333.ECUMN_4541,iECW_1372.ECW_m4374,iEKO11_1354.EKO11_4310,iETEC_1333.ETEC_4270,iEcDH1_1363.EcDH1_3982,iEcE24377_1341.EcE24377A_4557,iEcHS_1320.EcHS_A4249,iEcSMS35_1347.EcSMS35_4469,iEcolC_1368.EcolC_4015,iJN746.PP_4116,iJO1366.b4015,iJR904.b4015,iLF82_1304.LF82_0012,iNRG857_1313.NRG857_20015,iSDY_1059.SDY_4328,iUMNK88_1353.UMNK88_4859,iWFL_1372.ECW_m4374,iY75_1357.Y75_RS20880	Bacteria	1MWIF@1224,1RQAK@1236,3XNEM@561,COG2224@1,COG2224@2	NA|NA|NA	C	Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates
C1_03597	316407.85676766	2.2e-311	1074.3	Escherichia	aceB	GO:0003674,GO:0003824,GO:0004474,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006081,GO:0006082,GO:0006097,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044424,GO:0044464,GO:0046487,GO:0046912,GO:0071704	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000			iEC55989_1330.EC55989_4499,iLF82_1304.LF82_0013,iNRG857_1313.NRG857_20010	Bacteria	1MVEV@1224,1RPVI@1236,3XP4H@561,COG2225@1,COG2225@2	NA|NA|NA	H	Belongs to the malate synthase family
C1_03598	199310.c4970	1.9e-180	638.3	Escherichia	metAS	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0008899,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016750,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.46	ko:K00651	ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230	M00017	R01777	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000			iECUMN_1333.ECUMN_4539,iSBO_1134.SBO_4033,iSbBS512_1146.SbBS512_E4507	Bacteria	1MV64@1224,1RM7T@1236,3XNKY@561,COG1897@1,COG1897@2	NA|NA|NA	E	Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine
C1_03599	155864.EDL933_5339	4.2e-77	293.9	Escherichia	yjaB			ko:K03827					ko00000,ko01000				Bacteria	1RI35@1224,1S362@1236,3XPMC@561,COG0454@1,COG0456@2	NA|NA|NA	K	transferase activity, transferring acyl groups
C1_03604	198214.SF4078	7e-300	1035.8	Gammaproteobacteria	purH	GO:0003674,GO:0003824,GO:0004643,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147			iEcHS_1320.EcHS_A4240,iPC815.YPO3728	Bacteria	1MUDQ@1224,1RMWS@1236,COG0138@1,COG0138@2	NA|NA|NA	F	bifunctional purine biosynthesis protein purh
C1_03605	481805.EcolC_4020	2.3e-248	864.4	Escherichia	purD	GO:0000166,GO:0003674,GO:0003824,GO:0004637,GO:0005488,GO:0005524,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000			iECNA114_1301.ECNA114_3417,iECSF_1327.ECSF_3859,iJN746.PP_4823,iPC815.YPO3729	Bacteria	1MUAH@1224,1RNS4@1236,3XNXC@561,COG0151@1,COG0151@2	NA|NA|NA	F	Belongs to the GARS family
C1_03606	469008.B21_03834	4.3e-242	843.6	Escherichia	zraR	GO:0000156,GO:0000160,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0023052,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035556,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576		ko:K07713	ko02020,map02020	M00499			ko00000,ko00001,ko00002,ko02022				Bacteria	1MU0N@1224,1RMCK@1236,3XMIG@561,COG2204@1,COG2204@2	NA|NA|NA	K	Member of the two-component regulatory system ZraS ZraR. When activated by ZraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon
C1_03607	198214.SF4075	4e-251	873.6	Gammaproteobacteria	zraS	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010043,GO:0010288,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031224,GO:0031226,GO:0035556,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070887,GO:0071241,GO:0071248,GO:0071284,GO:0071294,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.7.13.3	ko:K07709	ko02020,map02020	M00499			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	1RCM9@1224,1RSI4@1236,COG4191@1,COG4191@2	NA|NA|NA	T	Member of the two-component regulatory system ZraS ZraR. May function as a membrane-associated protein kinase that phosphorylates ZraR in response to high concentrations of zinc or lead in the medium
C1_03609	155864.EDL933_5333	1.3e-64	252.3	Escherichia	zraP	GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005623,GO:0008270,GO:0016151,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0050897		ko:K07803	ko02020,map02020				ko00000,ko00001,ko03110				Bacteria	1RI83@1224,1S6TF@1236,3XPNA@561,COG3678@1,COG3678@2	NA|NA|NA	NPTU	Binds zinc. Could be an important component of the zinc- balancing mechanism
C1_03610	198214.SF4073	1.6e-109	402.1	Gammaproteobacteria	yjaH												Bacteria	1QFI0@1224,1RPY5@1236,28HWS@1,2Z82N@2	NA|NA|NA	S	Protein of unknown function (DUF1481)
C1_03611	1440052.EAKF1_ch1916c	1.2e-39	168.7	Escherichia	hupA	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0005737,GO:0005829,GO:0006139,GO:0006323,GO:0006351,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009889,GO:0009987,GO:0010467,GO:0010556,GO:0016043,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051276,GO:0051716,GO:0060255,GO:0065007,GO:0071103,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:1990104,GO:1990178,GO:2001141		ko:K03530,ko:K05787					ko00000,ko03032,ko03036,ko03400				Bacteria	1MZ5B@1224,1S8VH@1236,3XPW4@561,COG0776@1,COG0776@2	NA|NA|NA	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
C1_03612	316407.85676070	1.4e-107	395.6	Escherichia	yjaG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K09891					ko00000				Bacteria	1MWSN@1224,1RQDG@1236,3XPD1@561,COG3068@1,COG3068@2	NA|NA|NA	S	Protein of unknown function (DUF416)
C1_03613	155864.EDL933_5329	9.7e-126	456.1	Escherichia	nfi	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0034641,GO:0043170,GO:0043737,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	3.1.21.7	ko:K05982					ko00000,ko01000,ko03400				Bacteria	1MWRN@1224,1RRYH@1236,3XMDC@561,COG1515@1,COG1515@2	NA|NA|NA	L	DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA
C1_03614	316407.85676072	2e-205	721.5	Escherichia	hemE	GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006725,GO:0006778,GO:0006779,GO:0006780,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019353,GO:0019438,GO:0019752,GO:0033013,GO:0033014,GO:0033526,GO:0034641,GO:0042168,GO:0042440,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046394,GO:0046483,GO:0046501,GO:0046502,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000			iPC815.YPO3734,iSBO_1134.SBO_4018	Bacteria	1MUG1@1224,1RMDH@1236,3XN6T@561,COG0407@1,COG0407@2	NA|NA|NA	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C1_03615	316407.85676073	2e-151	541.6	Escherichia	nudC	GO:0003674,GO:0003824,GO:0004551,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0033554,GO:0034641,GO:0035529,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	1.3.7.1,3.6.1.22	ko:K03426,ko:K20449	ko00760,ko01100,ko01120,ko04146,map00760,map01100,map01120,map04146		R00103,R03004,R03164,R11104	RC00002,RC02422	ko00000,ko00001,ko01000			iAF1260.b3996,iB21_1397.B21_03826,iBWG_1329.BWG_3656,iEC55989_1330.EC55989_4481,iECBD_1354.ECBD_4036,iECB_1328.ECB_03873,iECDH10B_1368.ECDH10B_4185,iECDH1ME8569_1439.ECDH1ME8569_3856,iECD_1391.ECD_03873,iECIAI1_1343.ECIAI1_4211,iECO103_1326.ECO103_4745,iECO111_1330.ECO111_4813,iECO26_1355.ECO26_5105,iECSE_1348.ECSE_4284,iECW_1372.ECW_m4355,iEKO11_1354.EKO11_4325,iETEC_1333.ETEC_4256,iEcDH1_1363.EcDH1_3998,iEcE24377_1341.EcE24377A_4539,iEcHS_1320.EcHS_A4230,iEcolC_1368.EcolC_4029,iJO1366.b3996,iPC815.YPO3736,iSSON_1240.SSON_4169,iUMNK88_1353.UMNK88_4837,iWFL_1372.ECW_m4355,iY75_1357.Y75_RS17065,iYL1228.KPN_04378	Bacteria	1QGCX@1224,1RP0Y@1236,3XMM1@561,COG2816@1,COG2816@2	NA|NA|NA	L	Belongs to the Nudix hydrolase family. NudC subfamily
C1_03616	155864.EDL933_5326	1.3e-84	318.9	Escherichia	rsd	GO:0000988,GO:0000989,GO:0003674,GO:0008150,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141		ko:K07740					ko00000				Bacteria	1RHBB@1224,1S420@1236,3XPHA@561,COG3160@1,COG3160@2	NA|NA|NA	K	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
C1_03617	316407.85676075	0.0	1285.4	Escherichia	thiC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000			iECABU_c1320.ECABU_c45100	Bacteria	1MUVV@1224,1RP1F@1236,3XMHV@561,COG0422@1,COG0422@2	NA|NA|NA	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C1_03618	198214.SF4065	4.4e-112	410.6	Gammaproteobacteria	thiE	GO:0000287,GO:0003674,GO:0003824,GO:0004789,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.3,2.7.1.49,2.7.4.7	ko:K00788,ko:K14153	ko00730,ko01100,map00730,map01100	M00127	R03223,R03471,R04509,R10712	RC00002,RC00017,RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000			iE2348C_1286.E2348C_4300,iSSON_1240.SSON_4166	Bacteria	1RDSU@1224,1SYGR@1236,COG0352@1,COG0352@2	NA|NA|NA	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
C1_03619	198214.SF4064	6.1e-137	493.4	Gammaproteobacteria	thiF	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008144,GO:0008270,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0097159,GO:0097367,GO:1901265,GO:1901363	2.7.7.73,2.7.7.80	ko:K03148,ko:K21029	ko00730,ko01100,ko04122,map00730,map01100,map04122		R07459	RC00043	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_2482,iECDH1ME8569_1439.ECDH1ME8569_3852,iECDH1ME8569_1439.EcDH1_4002,iECIAI39_1322.ECIAI39_4382,iEcDH1_1363.EcDH1_4002,iEcSMS35_1347.EcSMS35_0851	Bacteria	1MW7H@1224,1RPJ3@1236,COG0476@1,COG0476@2	NA|NA|NA	H	COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
C1_03620	469008.B21_03821	9.5e-29	132.1	Escherichia	thiS		2.8.1.10	ko:K03149,ko:K03154	ko00730,ko01100,ko04122,map00730,map01100,map04122		R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000			iAF1260.b4407,iBWG_1329.BWG_3651,iECDH10B_1368.ECDH10B_4180,iECDH1ME8569_1439.ECDH1ME8569_3851,iECDH1ME8569_1439.EcDH1_4003,iEcDH1_1363.EcDH1_4003,iEcolC_1368.EcolC_4034,iJO1366.b4407,iJR904.b4407,iUMNK88_1353.UMNK88_4832,iY75_1357.Y75_RS17090	Bacteria	1N6ZF@1224,1SCFT@1236,3XPYX@561,COG2104@1,COG2104@2	NA|NA|NA	H	thiamine biosynthesis protein ThiS
C1_03621	469008.B21_03820	7.7e-135	486.5	Escherichia	thiG	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100		R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000			iECABU_c1320.ECABU_c45060,iECO26_1355.ECO26_5099,ic_1306.c4947	Bacteria	1N0N5@1224,1RMPD@1236,3XN6M@561,COG2022@1,COG2022@2	NA|NA|NA	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S
C1_03622	469008.B21_03819	3.3e-219	767.3	Escherichia	thiH	GO:0003674,GO:0003824,GO:0005488,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016829,GO:0016830,GO:0017144,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0036355,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.19	ko:K03150	ko00730,ko01100,map00730,map01100		R10246	RC01434,RC03095	ko00000,ko00001,ko01000			iPC815.YPO3743,iSF_1195.SF4062,iSFxv_1172.SFxv_4429,iS_1188.S3673	Bacteria	1MXK0@1224,1RNTV@1236,3XNBA@561,COG0502@1,COG0502@2	NA|NA|NA	H	2-iminoacetate synthase activity
C1_03623	155864.EDL933_5318	0.0	2712.9	Escherichia	rpoC	GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.6	ko:K03046,ko:K13797	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400				Bacteria	1MU3M@1224,1RPYH@1236,3XMYU@561,COG0086@1,COG0086@2	NA|NA|NA	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C1_03624	155864.EDL933_5317	0.0	2631.7	Escherichia	rpoB	GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.6	ko:K03043,ko:K13797	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400				Bacteria	1MUC4@1224,1RMK0@1236,3XMJ3@561,COG0085@1,COG0085@2	NA|NA|NA	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C1_03625	155864.EDL933_5316	1.4e-49	202.2	Escherichia	rplL	GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042802,GO:0042803,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0046983,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02935	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1RGU4@1224,1S5V7@1236,3XPRN@561,COG0222@1,COG0222@2	NA|NA|NA	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
C1_03626	1440052.EAKF1_ch1934c	1.7e-79	302.0	Escherichia	rplJ	GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0017148,GO:0019222,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113		ko:K02864,ko:K02935	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1RAN5@1224,1S286@1236,3XM5M@561,COG0244@1,COG0244@2	NA|NA|NA	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C1_03627	155864.EDL933_5314	2.4e-119	434.9	Escherichia	rplA	GO:0000027,GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006417,GO:0006446,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0017148,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045947,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113		ko:K02863	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1MUE6@1224,1RMDW@1236,3XMSJ@561,COG0081@1,COG0081@2	NA|NA|NA	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
C1_03628	1197719.A464_4165	2.5e-71	274.6	Salmonella	rplK	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010467,GO:0015934,GO:0015968,GO:0016043,GO:0019538,GO:0019843,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0032984,GO:0032991,GO:0033554,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0042594,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0051716,GO:0065003,GO:0070925,GO:0071496,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02867	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1RA2M@1224,1S22R@1236,3ZIPY@590,COG0080@1,COG0080@2	NA|NA|NA	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C1_03629	155864.EDL933_5312	8.2e-99	366.3	Escherichia	nusG	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0030312,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141		ko:K02601,ko:K05785					ko00000,ko03000,ko03009,ko03021				Bacteria	1MU14@1224,1RMW0@1236,3XNVU@561,COG0250@1,COG0250@2	NA|NA|NA	K	Participates in transcription elongation, termination and antitermination. In the absence of Rho, increases the rate of transcription elongation by the RNA polymerase (RNAP), probably by partially suppressing pausing. In the presence of Rho, modulates most Rho-dependent termination events by interacting with the RNAP to render the complex more susceptible to the termination activity of Rho. May be required to overcome a kinetic limitation of Rho to function at certain terminators. Also involved in ribosomal RNA
C1_03630	1440052.EAKF1_ch1938c	9.3e-57	226.1	Escherichia	secE	GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0031522,GO:0032940,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044425,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680		ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2			Bacteria	1RDI9@1224,1S3PA@1236,3XPKH@561,COG0690@1,COG0690@2	NA|NA|NA	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
C1_03631	155864.EDL933_5310	2.5e-225	787.7	Escherichia	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944		ko:K02358					ko00000,ko03012,ko03029,ko04147				Bacteria	1MVC0@1224,1RMYX@1236,3XN6C@561,COG0050@1,COG0050@2	NA|NA|NA	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C1_03636	155864.EDL933_5308	2.7e-174	617.8	Escherichia	coaA	GO:0003674,GO:0003824,GO:0004594,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.33	ko:K00867	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000			iECDH1ME8569_1439.ECDH1ME8569_3838,iECH74115_1262.ECH74115_5439,iECSE_1348.ECSE_4265,iECSF_1327.ECSF_3833,iECSP_1301.ECSP_5045,iECW_1372.ECW_m4332,iEcDH1_1363.EcDH1_4016,iEcolC_1368.EcolC_4046,iPC815.YPO3758,iSFV_1184.SFV_4047,iSFxv_1172.SFxv_4418,iWFL_1372.ECW_m4332,iZ_1308.Z5545	Bacteria	1MV3M@1224,1RNXX@1236,3XMR3@561,COG1072@1,COG1072@2	NA|NA|NA	F	Pantothenic acid kinase
C1_03637	469008.B21_03807	2.2e-179	634.8	Escherichia	birA	GO:0000166,GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004077,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009305,GO:0009374,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0017053,GO:0017076,GO:0017144,GO:0018130,GO:0018271,GO:0019538,GO:0019752,GO:0019842,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032991,GO:0033218,GO:0033293,GO:0034641,GO:0035639,GO:0036094,GO:0036211,GO:0042364,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043565,GO:0043603,GO:0043604,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1990837	2.7.1.33,6.3.4.15	ko:K01947,ko:K03524,ko:K04096	ko00770,ko00780,ko01100,map00770,map00780,map01100	M00120	R01074,R02971,R03018,R04391,R05145	RC00002,RC00017,RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko00002,ko01000,ko03000				Bacteria	1MWCC@1224,1RNGC@1236,3XN5Y@561,COG0340@1,COG0340@2,COG1654@1,COG1654@2	NA|NA|NA	K	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C1_03638	198214.SF4050	4.8e-201	706.8	Gammaproteobacteria	murB	GO:0000166,GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008360,GO:0008762,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0022603,GO:0022604,GO:0030203,GO:0034645,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045229,GO:0048037,GO:0050660,GO:0050662,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0055114,GO:0065007,GO:0065008,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100		R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011			iECED1_1282.ECED1_4683,iECUMN_1333.ECUMN_4498_AT6,iLF82_1304.LF82_1416,iNRG857_1313.NRG857_19845	Bacteria	1MXDH@1224,1RNXK@1236,COG0812@1,COG0812@2	NA|NA|NA	M	cell wall formation
C1_03643	316407.85676094	5.7e-155	553.5	Escherichia	murI	GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008881,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0030203,GO:0034645,GO:0036361,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0047661,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100		R00260	RC00302	ko00000,ko00001,ko01000,ko01011			iAPECO1_1312.APECO1_2496,iEC042_1314.EC042_4342,iECOK1_1307.ECOK1_4443,iECS88_1305.ECS88_4426,iPC815.YPO3909,iUMN146_1321.UM146_20110,iUTI89_1310.UTI89_C4562	Bacteria	1NAI2@1224,1RPU9@1236,3XN8U@561,COG0796@1,COG0796@2	NA|NA|NA	M	Provides the (R)-glutamate required for cell wall biosynthesis
C1_03644	316407.85676095	0.0	1258.0	Escherichia	btuB	GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0006810,GO:0006811,GO:0008150,GO:0015075,GO:0015267,GO:0015318,GO:0015889,GO:0015893,GO:0016020,GO:0016021,GO:0019904,GO:0022803,GO:0022838,GO:0022857,GO:0031224,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0050896,GO:0051179,GO:0051180,GO:0051181,GO:0051234,GO:0055085,GO:0071702,GO:0071705		ko:K16092					ko00000,ko02000	1.B.14.3		iECB_1328.ECB_03851,iECP_1309.ECP_4183,iSF_1195.SF4048,iS_1188.S3696	Bacteria	1MW63@1224,1RMFJ@1236,3XN0V@561,COG4206@1,COG4206@2	NA|NA|NA	P	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB
C1_03645	316407.85676096	6.7e-209	733.0	Escherichia	trmA	GO:0000049,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016740,GO:0016741,GO:0019843,GO:0030488,GO:0030696,GO:0030697,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363	2.1.1.190,2.1.1.35	ko:K00557,ko:K03215					ko00000,ko01000,ko03009,ko03016				Bacteria	1MY45@1224,1RN2B@1236,3XNI9@561,COG2265@1,COG2265@2	NA|NA|NA	J	Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA)
C1_03646	155864.EDL933_5302	1.2e-58	232.3	Escherichia	yijD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1RH5N@1224,1S68Y@1236,2ARMX@1,31GYK@2,3XPPP@561	NA|NA|NA	S	Protein of unknown function (DUF1422)
C1_03647	155864.EDL933_5301	1.2e-123	449.1	Escherichia	fabR	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K22105					ko00000,ko03000				Bacteria	1MUJ5@1224,1RN9W@1236,3XNXE@561,COG1309@1,COG1309@2	NA|NA|NA	K	fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer
C1_03648	316407.85676099	6.4e-273	946.0	Escherichia	sthA	GO:0000166,GO:0003674,GO:0003824,GO:0003957,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0008746,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0016491,GO:0016651,GO:0016652,GO:0019725,GO:0022857,GO:0022890,GO:0034220,GO:0036094,GO:0042592,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050662,GO:0050789,GO:0050794,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0065007,GO:0065008,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901363,GO:1902600	1.6.1.1	ko:K00322	ko00760,ko01100,map00760,map01100		R00112	RC00001	ko00000,ko00001,ko01000			iECED1_1282.ECED1_4669,iECs_1301.ECs4891,iZ_1308.Z5521	Bacteria	1MVVE@1224,1RMJT@1236,3XN5G@561,COG1249@1,COG1249@2	NA|NA|NA	C	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation
C1_03649	155864.EDL933_5297	3.9e-170	604.0	Escherichia	oxyR	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0001130,GO:0001131,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0033554,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2000142,GO:2001141		ko:K04761	ko02026,map02026				ko00000,ko00001,ko03000				Bacteria	1MVA1@1224,1RPAJ@1236,3XNXK@561,COG0583@1,COG0583@2	NA|NA|NA	K	Hydrogen peroxide sensor. Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS (a regulatory RNA), dps, fur and grxA. OxyR expression is negatively autoregulated by binding to a 43 bp region upstream of its own coding sequence. OxyR is inactivated by reduction of its essential disulfide bond by the product of GrxA, itself positively regulated by OxyR. Has also a positive regulatory effect on the production of surface proteins that control the colony morphology and auto-aggregation ability
C1_03650	199310.c4921	3.3e-239	833.9	Escherichia	yjjL											iEC55989_1330.EC55989_4444,iEcE24377_1341.EcE24377A_4501,iYL1228.KPN_01586	Bacteria	1MVPS@1224,1RPRB@1236,3XP6M@561,COG2271@1,COG2271@2	NA|NA|NA	P	Probably responsible for the transport of L-galactonate from the periplasm across the inner membrane. Is essential for growth on L-galactonate as the sole carbon source
C1_03651	199310.c4920	3.5e-243	847.0	Gammaproteobacteria	rspA	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0008150,GO:0008152,GO:0008927,GO:0009056,GO:0016052,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043169,GO:0044238,GO:0046872,GO:0071704,GO:1901575	4.2.1.8	ko:K08323	ko00040,ko01100,map00040,map01100	M00061	R05606	RC00543	ko00000,ko00001,ko00002,ko01000				Bacteria	1R74Y@1224,1S0VE@1236,COG4948@1,COG4948@2	NA|NA|NA	M	Belongs to the mandelate racemase muconate lactonizing enzyme family
C1_03652	316407.85676101	4.4e-258	896.7	Escherichia	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,4.3.2.1	ko:K01755,ko:K14681	ko00220,ko00250,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map01100,map01110,map01130,map01210,map01230	M00028,M00029,M00844,M00845	R00259,R01086	RC00004,RC00064,RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	1MUTU@1224,1RMA3@1236,3XMS6@561,COG0165@1,COG0165@2	NA|NA|NA	E	argininosuccinate lyase
C1_03653	511145.b3959	5.2e-139	500.4	Escherichia	argB	GO:0003674,GO:0003824,GO:0003991,GO:0004358,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016407,GO:0016410,GO:0016597,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0033554,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,2.7.2.8	ko:K00930,ko:K14682	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02649	RC00002,RC00004,RC00043,RC00064	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_2508,iB21_1397.B21_03793,iEC55989_1330.EC55989_4441,iECB_1328.ECB_03844,iECDH10B_1368.ECDH10B_4147,iECDH1ME8569_1439.ECDH1ME8569_3827,iECD_1391.ECD_03844,iECH74115_1262.ECH74115_5419,iECIAI1_1343.ECIAI1_4167,iECO103_1326.ECO103_4715,iECOK1_1307.ECOK1_4431,iECP_1309.ECP_2830,iECS88_1305.ECS88_4414,iECSE_1348.ECSE_4252,iETEC_1333.ETEC_4227,iEcE24377_1341.EcE24377A_4498,iEcHS_1320.EcHS_A4193,iEcolC_1368.EcolC_4057,iLF82_1304.LF82_0116,iNRG857_1313.NRG857_13920,iSbBS512_1146.SbBS512_E4445,iUMN146_1321.UM146_20050,iUMNK88_1353.UMNK88_4797,iUTI89_1310.UTI89_C4550,iY75_1357.Y75_RS17255	Bacteria	1MU17@1224,1RNKK@1236,3XN7Q@561,COG0548@1,COG0548@2	NA|NA|NA	F	Catalyzes the ATP-dependent phosphorylation of N-acetyl- L-glutamate
C1_03654	316407.85676103	5.2e-192	676.8	Escherichia	argC	GO:0003674,GO:0003824,GO:0003942,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000			iLJ478.TM1782,iSSON_1240.SSON_4131,iYO844.BSU11190	Bacteria	1MVJ6@1224,1RNMX@1236,3XM7I@561,COG0002@1,COG0002@2	NA|NA|NA	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C1_03655	199310.c4916	6.3e-226	789.6	Escherichia	argE	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0008777,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0019752,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0046914,GO:0050897,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000			iECUMN_1333.ECUMN_4488	Bacteria	1MVBR@1224,1RNDG@1236,3XMEN@561,COG0624@1,COG0624@2	NA|NA|NA	E	Displays a broad specificity and can also deacylate substrates such as acetylarginine, acetylhistidine or acetylglutamate semialdehyde
C1_03656	199310.c4915	0.0	1750.7	Escherichia	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008964,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0072350	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000			iJN678.ppc,iSFV_1184.SFV_4025	Bacteria	1MUD5@1224,1RPTP@1236,3XM42@561,COG2352@1,COG2352@2	NA|NA|NA	H	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C1_03657	469008.B21_03789	0.0	1171.4	Escherichia	cptA	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016772,GO:0016776,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046401,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.7.8.42,2.7.8.43	ko:K03760,ko:K12975,ko:K19353	ko00540,ko01503,map00540,map01503	M00722,M00723	R11204,R11205,R11555,R11556,R11557	RC00002,RC00017,RC00428	ko00000,ko00001,ko00002,ko01000,ko01005			iSSON_1240.SSON_3844	Bacteria	1MWS7@1224,1RQI2@1236,3XMV4@561,COG2194@1,COG2194@2	NA|NA|NA	S	Catalyzes the addition of a phosphoethanolamine moiety to the outer membrane lipopolysaccharide core
C1_03658	469008.B21_03788	3.4e-160	570.9	Escherichia	yijO	GO:0003674,GO:0003700,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141											Bacteria	1N7DZ@1224,1RN9G@1236,3XN7P@561,COG2207@1,COG2207@2	NA|NA|NA	K	transcriptional regulator
C1_03659	198214.SF4030	1.2e-55	222.2	Gammaproteobacteria	fruA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090582	2.7.1.202,2.7.1.56	ko:K00882,ko:K02768,ko:K02769,ko:K02770,ko:K11202	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273,M00306	R02071,R03232	RC00002,RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1		iEcSMS35_1347.EcSMS35_2314,iSbBS512_1146.SbBS512_E0796	Bacteria	1RICG@1224,1S65D@1236,COG1445@1,COG1445@2	NA|NA|NA	G	pts system
C1_03660	316407.85676109	1.5e-163	582.0	Escherichia	pflC		1.97.1.4	ko:K04069			R04710		ko00000,ko01000			e_coli_core.b3952,iAF1260.b3952,iAPECO1_1312.APECO1_2515,iBWG_1329.BWG_3620,iECDH10B_1368.ECDH10B_4140,iECDH1ME8569_1439.ECDH1ME8569_3820,iEcDH1_1363.EcDH1_4034,iJO1366.b3952,iJR904.b3952,iLF82_1304.LF82_1623,iNRG857_1313.NRG857_19745,iY75_1357.Y75_RS17295	Bacteria	1PD9E@1224,1RQG5@1236,3XN6N@561,COG1180@1,COG1180@2	NA|NA|NA	O	Activation of pyruvate formate-lyase 2 under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C1_03661	469008.B21_03785	0.0	1516.1	Escherichia	pflD		2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120		R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000			iECH74115_1262.ECH74115_5411,iECSP_1301.ECSP_5020,iECs_1301.ECs4880,iZ_1308.Z5507	Bacteria	1MWBF@1224,1RMEK@1236,3XNTU@561,COG1882@1,COG1882@2	NA|NA|NA	C	formate C-acetyltransferase activity
C1_03662	155864.EDL933_5286	5e-48	196.8	Escherichia	frwB	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090582		ko:K11202		M00306			ko00000,ko00002,ko01000,ko02000	4.A.2.1			Bacteria	1RHSU@1224,1S6R1@1236,3XPSP@561,COG1445@1,COG1445@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FrwABC PTS system is involved in fructose transport
C1_03663	316407.85676112	3.6e-191	674.1	Escherichia	frwC	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016021,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034219,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563		ko:K11201,ko:K11202,ko:K11203		M00306			ko00000,ko00002,ko01000,ko02000	4.A.2.1			Bacteria	1P0NB@1224,1RPQZ@1236,3XNJ3@561,COG1299@1,COG1299@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
C1_03664	155864.EDL933_5283	0.0	1620.9	Escherichia	ptsA		2.7.1.121,2.7.1.194,2.7.1.197,2.7.1.200,2.7.1.202,2.7.3.9	ko:K02768,ko:K02769,ko:K02770,ko:K02773,ko:K02784,ko:K02798,ko:K02806,ko:K02821,ko:K05881,ko:K08483,ko:K08485,ko:K11183,ko:K11184,ko:K11189,ko:K11201,ko:K18531	ko00051,ko00052,ko00053,ko00561,ko01100,ko01120,ko02060,map00051,map00052,map00053,map00561,map01100,map01120,map02060	M00273,M00274,M00279,M00283,M00306,M00550	R01012,R02704,R03232,R05570,R07671	RC00015,RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1,4.A.2.1.12,4.A.2.1.2,4.A.2.1.24,4.A.2.1.5,4.A.5.1,4.A.7.1,8.A.7,8.A.8.1.1		e_coli_core.b2415,iAF1260.b2415,iB21_1397.B21_02276,iB21_1397.B21_02277,iBWG_1329.BWG_2177,iE2348C_1286.E2348C_2601,iE2348C_1286.E2348C_2602,iEC042_1314.EC042_2624,iEC042_1314.EC042_2625,iEC55989_1330.EC55989_2705,iECABU_c1320.ECABU_c27360,iECABU_c1320.ECABU_c47530,iECBD_1354.ECBD_1265,iECBD_1354.ECBD_1266,iECB_1328.ECB_02315,iECB_1328.ECB_02316,iECDH10B_1368.ECDH10B_2580,iECDH1ME8569_1439.ECDH1ME8569_2349,iECDH1ME8569_1439.EcDH1_1246,iECD_1391.ECD_02315,iECD_1391.ECD_02316,iECED1_1282.ECED1_2859,iECH74115_1262.ECH74115_3646,iECH74115_1262.ECH74115_3647,iECIAI1_1343.ECIAI1_2473,iECIAI1_1343.ECIAI1_2474,iECIAI39_1322.ECIAI39_0923,iECIAI39_1322.ECIAI39_2561,iECIAI39_1322.ECIAI39_2562,iECNA114_1301.ECNA114_2492,iECO103_1326.ECO103_2934,iECO103_1326.ECO103_2935,iECO111_1330.ECO111_3145,iECO111_1330.ECO111_3146,iECO26_1355.ECO26_3468,iECO26_1355.ECO26_3469,iECOK1_1307.ECOK1_2732,iECP_1309.ECP_2439,iECP_1309.ECP_2440,iECS88_1305.ECS88_2605,iECSE_1348.ECSE_2706,iECSE_1348.ECSE_2707,iECSF_1327.ECSF_2279,iECSP_1301.ECSP_3363,iECSP_1301.ECSP_3364,iECUMN_1333.ECUMN_2737,iECUMN_1333.ECUMN_2738,iECUMN_1333.ECUMN_4728,iECW_1372.ECW_m2644,iECW_1372.ECW_m2645,iECs_1301.ECs1703,iECs_1301.ECs3287,iECs_1301.ECs3288,iEKO11_1354.EKO11_1312,iEKO11_1354.EKO11_1313,iETEC_1333.ETEC_2528,iEcDH1_1363.EcDH1_1246,iEcE24377_1341.EcE24377A_2702,iEcE24377_1341.EcE24377A_2703,iEcHS_1320.EcHS_A2550,iEcHS_1320.EcHS_A2551,iEcSMS35_1347.EcSMS35_2570,iEcSMS35_1347.EcSMS35_2571,iEcSMS35_1347.EcSMS35_4666,iEcolC_1368.EcolC_1262,iEcolC_1368.EcolC_1263,iG2583_1286.G2583_2947,iJO1366.b2415,iJR904.b2415,iLF82_1304.LF82_1769,iLF82_1304.LF82_1770,iNRG857_1313.NRG857_12110,iNRG857_1313.NRG857_12115,iSBO_1134.SBO_2155,iSBO_1134.SBO_2439,iSBO_1134.SBO_2440,iSDY_1059.SDY_2612,iSDY_1059.SDY_2613,iSFV_1184.SFV_2467,iSFV_1184.SFV_2468,iSF_1195.SF2470,iSF_1195.SF2471,iSFxv_1172.SFxv_2719,iSFxv_1172.SFxv_2720,iSSON_1240.SSON_2504,iSSON_1240.SSON_2505,iS_1188.S2616,iS_1188.S2617,iSbBS512_1146.SbBS512_E0794,iSbBS512_1146.SbBS512_E2765,iUMN146_1321.UM146_04545,iUMNK88_1353.UMNK88_3017,iUMNK88_1353.UMNK88_3018,iUTI89_1310.UTI89_C2749,iWFL_1372.ECW_m2644,iWFL_1372.ECW_m2645,iY75_1357.Y75_RS12655,iZ_1308.Z1969,iZ_1308.Z3681,iZ_1308.Z3682,ic_1306.c2950,ic_1306.c5284	Bacteria	1MUT8@1224,1RN6R@1236,3XP7E@561,COG1080@1,COG1080@2,COG1762@1,COG1762@2,COG1925@1,COG1925@2	NA|NA|NA	G	Multifunctional protein that includes general (non sugar-specific) and sugar-specific components of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FrwABC PTS system is involved in fructose transport
C1_03665	481805.EcolC_4069	4e-116	424.1	Escherichia	tal	GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0016832,GO:0097023	2.2.1.2	ko:K00616,ko:K08313,ko:K08314	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000			iB21_1397.B21_03781,iECBD_1354.ECBD_4077,iECB_1328.ECB_03832,iECD_1391.ECD_03832,iECH74115_1262.ECH74115_5407,iECSP_1301.ECSP_5016,iECs_1301.ECs4875,iEcHS_1320.EcHS_A4181,iG2583_1286.G2583_4758,iSBO_1134.SBO_0715,iZ_1308.Z5501	Bacteria	1MWQ8@1224,1RNWN@1236,3XQP0@561,COG0176@1,COG0176@2	NA|NA|NA	G	Catalyzes the reversible formation of fructose 6- phosphate from dihydroxyacetone and D-glyceraldehyde 3-phosphate via an aldolization reaction
C1_03666	199310.c4904	2.5e-203	714.5	Escherichia	gldA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006066,GO:0006071,GO:0006081,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0008888,GO:0009056,GO:0009438,GO:0009987,GO:0015980,GO:0016052,GO:0016491,GO:0016614,GO:0016616,GO:0019147,GO:0019400,GO:0019405,GO:0019563,GO:0019588,GO:0019662,GO:0019751,GO:0042180,GO:0042182,GO:0042802,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046164,GO:0046174,GO:0046185,GO:0051596,GO:0055114,GO:0071704,GO:1901575,GO:1901615,GO:1901616	1.1.1.6	ko:K00005,ko:K08317	ko00561,ko00640,ko01100,map00561,map00640,map01100		R01034,R10715,R10717	RC00029,RC00117,RC00670	ko00000,ko00001,ko01000			iAF1260.b3945,iB21_1397.B21_03780,iBWG_1329.BWG_3614,iECABU_c1320.ECABU_c44570,iECBD_1354.ECBD_4078,iECB_1328.ECB_03831,iECDH10B_1368.ECDH10B_4134,iECDH1ME8569_1439.ECDH1ME8569_3814,iECD_1391.ECD_03831,iECED1_1282.ECED1_4651,iECIAI1_1343.ECIAI1_4154,iECNA114_1301.ECNA114_4086,iECO103_1326.ECO103_4702,iECO111_1330.ECO111_4771,iECO26_1355.ECO26_5062,iECP_1309.ECP_4159,iECSE_1348.ECSE_4239,iECSF_1327.ECSF_3807,iECW_1372.ECW_m4302,iEKO11_1354.EKO11_4366,iETEC_1333.ETEC_4214,iEcDH1_1363.EcDH1_4040,iEcE24377_1341.EcE24377A_4485,iEcHS_1320.EcHS_A4180,iEcolC_1368.EcolC_4070,iJO1366.b3945,iJR904.b3945,iLF82_1304.LF82_0835,iNRG857_1313.NRG857_19715,iSDY_1059.SDY_3780,iUMNK88_1353.UMNK88_4784,iWFL_1372.ECW_m4302,iY75_1357.Y75_RS17325,ic_1306.c4904	Bacteria	1MWAE@1224,1RN9F@1236,3XMX6@561,COG0371@1,COG0371@2	NA|NA|NA	C	Catalyzes the NAD-dependent oxidation of glycerol to dihydroxyacetone (glycerone). Allows microorganisms to utilize glycerol as a source of carbon under anaerobic conditions. In E.coli, an important role of GldA is also likely to regulate the intracellular level of dihydroxyacetone by catalyzing the reverse reaction, i.e. the conversion of dihydroxyacetone into glycerol. Possesses a broad substrate specificity, since it is also able to oxidize 1,2-propanediol and to reduce glycolaldehyde, methylglyoxal and hydroxyacetone into ethylene glycol, lactaldehyde and 1,2-propanediol, respectively
C1_03667	637910.ROD_00481	2.1e-161	575.1	Gammaproteobacteria	piv			ko:K07486					ko00000				Bacteria	1MXKJ@1224,1RSCP@1236,COG3547@1,COG3547@2	NA|NA|NA	L	Transposase
C1_03668	155864.EDL933_5280	8.6e-113	412.9	Escherichia	yijF			ko:K09974					ko00000				Bacteria	1RE1M@1224,1S44B@1236,3XN1E@561,COG3738@1,COG3738@2	NA|NA|NA	S	Domain of unknown function (DUF1287)
C1_03669	198214.SF4021	6.8e-159	566.6	Gammaproteobacteria	yijE	GO:0000099,GO:0000101,GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015318,GO:0015711,GO:0015849,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0098656,GO:1901682,GO:1903825,GO:1905039											Bacteria	1NEYM@1224,1RY44@1236,COG0697@1,COG0697@2	NA|NA|NA	EG	Permeases of the drug metabolite transporter (DMT) superfamily
C1_03670	155864.EDL933_5278	0.0	1471.1	Escherichia	katG	GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0042802,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110		R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000			iG2583_1286.G2583_4754	Bacteria	1MUBF@1224,1RNA5@1236,3XNUR@561,COG0376@1,COG0376@2	NA|NA|NA	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C1_03671	198214.SF4019	1e-167	595.9	Gammaproteobacteria	metF	GO:0000166,GO:0003674,GO:0003824,GO:0004489,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019438,GO:0019752,GO:0022607,GO:0034641,GO:0036094,GO:0042398,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0071949,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000			iPC815.YPO0117,iSBO_1134.SBO_3961	Bacteria	1MUC9@1224,1RMXS@1236,COG0685@1,COG0685@2	NA|NA|NA	E	Methylenetetrahydrofolate reductase
C1_03672	316407.85676120	0.0	1599.7	Escherichia	metL	GO:0003674,GO:0003824,GO:0004072,GO:0004412,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009085,GO:0009089,GO:0009090,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.3,2.7.2.4	ko:K00003,ko:K00928,ko:K12524,ko:K12525	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000			iECED1_1282.ECED1_4739,iSFV_1184.SFV_0001,iUMNK88_1353.UMNK88_4778,iYL1228.KPN_04234	Bacteria	1MW3H@1224,1RN1G@1236,3XPCP@561,COG0460@1,COG0460@2,COG0527@1,COG0527@2	NA|NA|NA	E	Homoserine dehydrogenase II
C1_03673	316407.85676121	6.4e-218	763.1	Escherichia	metB	GO:0000096,GO:0000097,GO:0000098,GO:0003674,GO:0003824,GO:0003962,GO:0004121,GO:0004123,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006090,GO:0006520,GO:0006534,GO:0006555,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009067,GO:0009069,GO:0009071,GO:0009086,GO:0009093,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019448,GO:0019450,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046395,GO:0046439,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	2.5.1.48,4.4.1.8	ko:K01739,ko:K01760	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04941,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00382,RC00420,RC00488,RC00710,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000			iAF1260.b3939,iBWG_1329.BWG_3608,iECDH10B_1368.ECDH10B_4128,iECDH1ME8569_1439.ECDH1ME8569_3808,iETEC_1333.ETEC_4208,iEcDH1_1363.EcDH1_4046,iEcHS_1320.EcHS_A4172,iEcolC_1368.EcolC_4076,iJO1366.b3939,iJR904.b3939,iSbBS512_1146.SbBS512_E3435,iUMNK88_1353.UMNK88_4777,iUTI89_1310.UTI89_C4524,iY75_1357.Y75_RS17365	Bacteria	1MU57@1224,1RMCV@1236,3XNGS@561,COG0626@1,COG0626@2	NA|NA|NA	E	Catalyzes the formation of L-cystathionine from O- succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma- replacement reaction. In the absence of thiol, catalyzes gamma- elimination to form 2-oxobutanoate, succinate and ammonia
C1_03674	155864.EDL933_5273	3.9e-53	213.8	Escherichia	metJ	GO:0000096,GO:0003674,GO:0003700,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006355,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0019752,GO:0031323,GO:0031326,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0140110,GO:1901564,GO:1901605,GO:1903506,GO:2000112,GO:2001141		ko:K03764					ko00000,ko03000				Bacteria	1RH3B@1224,1S5ZV@1236,3XPPY@561,COG3060@1,COG3060@2	NA|NA|NA	K	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
C1_03675	469008.B21_03772	2.1e-111	408.3	Escherichia	yiiX												Bacteria	1RBGX@1224,1S01D@1236,3XN9V@561,COG3863@1,COG3863@2	NA|NA|NA	S	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
C1_03676	481805.EcolC_4079	1.8e-46	191.4	Gammaproteobacteria	insA			ko:K07480,ko:K07489					ko00000				Bacteria	1RKZJ@1224,1S7ZU@1236,COG3677@1,COG3677@2	NA|NA|NA	L	InsA C-terminal domain
C1_03679	155864.EDL933_5269	0.0	2452.2	Escherichia													Bacteria	1MVV1@1224,1SKYM@1236,3XQSX@561,COG3209@1,COG3209@2	NA|NA|NA	M	Rhs elements have a nonessential function. They may play an important role in the natural ecology of the cell
C1_03680	155864.EDL933_5268	3.2e-35	153.7	Escherichia	rpmE	GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02909	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1MZ69@1224,1SCMH@1236,3XPZ0@561,COG0254@1,COG0254@2	NA|NA|NA	J	Binds the 23S rRNA
C1_03681	1440052.EAKF1_ch1978	0.0	1464.5	Escherichia	priA	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006276,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0010332,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042221,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0046677,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576		ko:K04066	ko03440,map03440				ko00000,ko00001,ko01000,ko03400				Bacteria	1MUUZ@1224,1RPZ7@1236,3XNVC@561,COG1198@1,COG1198@2	NA|NA|NA	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C1_03682	198214.SF4012	3.1e-192	677.6	Gammaproteobacteria	cytR	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K05499					ko00000,ko03000				Bacteria	1MVUR@1224,1RN8T@1236,COG1609@1,COG1609@2	NA|NA|NA	K	transcriptional
C1_03683	198214.SF4011	2.6e-136	491.5	Gammaproteobacteria	ftsN	GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0022402,GO:0022607,GO:0030428,GO:0031224,GO:0031226,GO:0032506,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047		ko:K03591					ko00000,ko03036				Bacteria	1PWIT@1224,1RNC1@1236,COG3087@1,COG3087@2	NA|NA|NA	D	Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases
C1_03684	155864.EDL933_5263	4.2e-92	344.0	Escherichia	hslV	GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016787,GO:0017076,GO:0019538,GO:0019904,GO:0022607,GO:0030163,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0051603,GO:0065003,GO:0070003,GO:0070011,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369	3.4.25.2	ko:K01419					ko00000,ko01000,ko01002				Bacteria	1MVF2@1224,1RP7P@1236,3XP2F@561,COG5405@1,COG5405@2	NA|NA|NA	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C1_03685	155864.EDL933_5262	9.5e-242	842.4	Escherichia	hslU	GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019904,GO:0022607,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043335,GO:0043933,GO:0044085,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1904949,GO:1905368,GO:1905369		ko:K03667					ko00000,ko03110				Bacteria	1MVK9@1224,1RMYV@1236,3XMJI@561,COG1220@1,COG1220@2	NA|NA|NA	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C1_03686	316407.85676130	3.1e-167	594.3	Escherichia	menA	GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006775,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009233,GO:0009234,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0032194,GO:0042180,GO:0042181,GO:0042362,GO:0042371,GO:0042373,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046428,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006			iECH74115_1262.ECH74115_5387,iG2583_1286.G2583_4737	Bacteria	1MXQQ@1224,1RPW5@1236,3XNGM@561,COG1575@1,COG1575@2	NA|NA|NA	H	Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK)
C1_03687	155864.EDL933_5260	2.7e-85	321.2	Escherichia	rraA	GO:0003674,GO:0004857,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008428,GO:0009892,GO:0009894,GO:0009895,GO:0010605,GO:0019219,GO:0019222,GO:0030234,GO:0031323,GO:0031324,GO:0031329,GO:0031330,GO:0032069,GO:0032074,GO:0043086,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060699,GO:0060700,GO:0060701,GO:0060702,GO:0065007,GO:0065009,GO:0080090,GO:0098772,GO:1902369		ko:K02553					ko00000,ko03019			iJR904.b3929	Bacteria	1RH18@1224,1RS9U@1236,3XMGB@561,COG0684@1,COG0684@2	NA|NA|NA	H	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome
C1_03688	155864.EDL933_5257	2.2e-24	117.9	Escherichia	zapB	GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0007049,GO:0008150,GO:0009987,GO:0019954,GO:0022402,GO:0022414,GO:0032153,GO:0032505,GO:0042802,GO:0043093,GO:0044424,GO:0044444,GO:0044464,GO:0051301	2.1.1.80,3.1.1.61	ko:K09892,ko:K13924	ko02020,ko02030,map02020,map02030	M00506			ko00000,ko00001,ko00002,ko01000,ko02022,ko02035,ko03036				Bacteria	1MZJE@1224,1S8TG@1236,3XPZA@561,COG3074@1,COG3074@2	NA|NA|NA	D	Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA
C1_03689	155864.EDL933_5256	3.7e-159	567.4	Escherichia	glpF	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009987,GO:0010035,GO:0010038,GO:0015144,GO:0015166,GO:0015168,GO:0015254,GO:0015267,GO:0015318,GO:0015791,GO:0015793,GO:0015850,GO:0016020,GO:0022803,GO:0022857,GO:0034219,GO:0042221,GO:0044464,GO:0046689,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0070887,GO:0071241,GO:0071248,GO:0071288,GO:0071702,GO:0071944,GO:1901618		ko:K02440,ko:K06188					ko00000,ko02000	1.A.8,1.A.8.1,1.A.8.2		iAF1260.b3927,iAPECO1_1312.APECO1_2542,iB21_1397.B21_03761,iBWG_1329.BWG_3596,iEC042_1314.EC042_4301,iEC55989_1330.EC55989_4405,iECABU_c1320.ECABU_c44330,iECBD_1354.ECBD_4097,iECB_1328.ECB_03812,iECDH10B_1368.ECDH10B_4116,iECDH1ME8569_1439.ECDH1ME8569_3796,iECD_1391.ECD_03812,iECED1_1282.ECED1_4629,iECH74115_1262.ECH74115_5382,iECIAI1_1343.ECIAI1_4132,iECNA114_1301.ECNA114_4066,iECO103_1326.ECO103_4601,iECO111_1330.ECO111_4750,iECO26_1355.ECO26_4658,iECOK1_1307.ECOK1_4395,iECP_1309.ECP_4136,iECS88_1305.ECS88_4377,iECSE_1348.ECSE_4216,iECSF_1327.ECSF_3787,iECSP_1301.ECSP_4990,iECUMN_1333.ECUMN_4455,iECW_1372.ECW_m4279,iECs_1301.ECs4852,iEKO11_1354.EKO11_4388,iETEC_1333.ETEC_4196,iEcDH1_1363.EcDH1_4058,iEcE24377_1341.EcE24377A_4461,iEcSMS35_1347.EcSMS35_4367,iEcolC_1368.EcolC_4091,iG2583_1286.G2583_4732,iJO1366.b3927,iJR904.b3927,iLF82_1304.LF82_0868,iNRG857_1313.NRG857_19605,iSSON_1240.SSON_4096,iUMNK88_1353.UMNK88_4764,iUTI89_1310.UTI89_C4511,iWFL_1372.ECW_m4279,iY75_1357.Y75_RS17425,iZ_1308.Z5472,ic_1306.c4879	Bacteria	1MXTJ@1224,1RP2X@1236,3XNW4@561,COG0580@1,COG0580@2	NA|NA|NA	G	Transporter of glycerol across the cytoplasmic membrane, with limited permeability to water and small uncharged compounds such as polyols
C1_03690	155864.EDL933_5255	7.1e-294	1015.8	Escherichia	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019405,GO:0019563,GO:0019751,GO:0033554,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046164,GO:0046174,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:1901575,GO:1901615,GO:1901616	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626		R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147			iE2348C_1286.E2348C_4230,iECNA114_1301.ECNA114_4065,iECSF_1327.ECSF_3786	Bacteria	1MUP7@1224,1RMAF@1236,3XN2R@561,COG0554@1,COG0554@2	NA|NA|NA	F	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C1_03691	198214.SF4003	1.5e-183	648.7	Gammaproteobacteria	glpX	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0030145,GO:0030388,GO:0042132,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0046914,GO:0050308,GO:0071704,GO:1901135,GO:1901576	2.2.1.1,3.1.3.11,3.1.3.37	ko:K00615,ko:K02446,ko:K11532	ko00010,ko00030,ko00051,ko00680,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00003,M00004,M00007,M00165,M00167	R00762,R01067,R01641,R01830,R01845,R04780,R06590	RC00017,RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000			iSF_1195.SF2920,iUMNK88_1353.UMNK88_4762	Bacteria	1MUB1@1224,1RR0E@1236,COG1494@1,COG1494@2	NA|NA|NA	G	Fructose-1,6-bisphosphatase
C1_03692	198214.SF4002	2.1e-129	468.4	Gammaproteobacteria	fpr	GO:0000166,GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004324,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006000,GO:0006001,GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0010035,GO:0016043,GO:0016052,GO:0016226,GO:0016491,GO:0016730,GO:0016731,GO:0019318,GO:0019320,GO:0022607,GO:0031163,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051186,GO:0055114,GO:0071704,GO:0071840,GO:0071949,GO:0097159,GO:1901265,GO:1901363,GO:1901575,GO:1901700	1.18.1.2,1.19.1.1	ko:K00528,ko:K05784	ko00362,ko00364,ko00622,ko01100,ko01120,ko01220,map00362,map00364,map00622,map01100,map01120,map01220	M00551	R05290,R05291,R05428,R05621,R05622,R05665,R08100,R08101,R08108,R08109,R08110,R10159	RC00270,RC01378,RC01450,RC01910	br01602,ko00000,ko00001,ko00002,ko01000			iECIAI39_1322.ECIAI39_3072,iEcSMS35_1347.EcSMS35_4364,iYL1228.KPN_04002	Bacteria	1MW37@1224,1RR95@1236,COG1018@1,COG1018@2	NA|NA|NA	C	COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1
C1_03693	198214.SF4001	4.5e-76	290.4	Gammaproteobacteria	uspD	GO:0000302,GO:0000303,GO:0000305,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0009314,GO:0009411,GO:0009416,GO:0009605,GO:0009628,GO:0009991,GO:0010035,GO:0031667,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:1901700		ko:K06149,ko:K14065					ko00000				Bacteria	1NR8I@1224,1SMC8@1236,COG0589@1,COG0589@2	NA|NA|NA	T	Required for resistance to DNA-damaging agents
C1_03694	155864.EDL933_5251	1.7e-45	188.3	Escherichia	yiiS												Bacteria	1NCVJ@1224,1SFQD@1236,3XPU6@561,COG3691@1,COG3691@2	NA|NA|NA	S	Protein of unknown function (DUF406)
C1_03695	155864.EDL933_5250	1.8e-80	305.1	Escherichia	yiiR	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1RD1M@1224,1S2CI@1236,3XPKT@561,COG3152@1,COG3152@2	NA|NA|NA	S	Protein of unknown function (DUF805)
C1_03696	155864.EDL933_5249	1.1e-104	386.0	Escherichia	yiiQ												Bacteria	1R3S9@1224,1S0JQ@1236,2CM5I@1,2Z94B@2,3XNRX@561	NA|NA|NA	S	Protein of unknown function (DUF1454)
C1_03697	155864.EDL933_5248	5.3e-136	490.3	Escherichia	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147				Bacteria	1MWK5@1224,1RM8I@1236,3XMQC@561,COG0149@1,COG0149@2	NA|NA|NA	F	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
C1_03698	469008.B21_03752	4.1e-141	507.3	Escherichia	cdh	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006220,GO:0006244,GO:0006629,GO:0006644,GO:0006650,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008715,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009395,GO:0009987,GO:0016020,GO:0016042,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046341,GO:0046342,GO:0046434,GO:0046475,GO:0046483,GO:0046486,GO:0046503,GO:0046700,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072529,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576	3.6.1.26	ko:K01521	ko00564,ko01110,map00564,map01110		R01797	RC00002	ko00000,ko00001,ko01000			iE2348C_1286.E2348C_4222,iECABU_c1320.ECABU_c44240,iLF82_1304.LF82_0283,iNRG857_1313.NRG857_19560,iSFxv_1172.SFxv_4357,ic_1306.c4870	Bacteria	1NGNY@1224,1RMYU@1236,3XNN6@561,COG2134@1,COG2134@2	NA|NA|NA	I	CDP-diacylglycerol catabolic process
C1_03699	198214.SF3995	5.9e-188	663.3	Gammaproteobacteria	sbp	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006790,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008152,GO:0008272,GO:0009987,GO:0015698,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043167,GO:0043168,GO:0043199,GO:0044237,GO:0044464,GO:0051179,GO:0051234,GO:0072348,GO:1901681		ko:K02048	ko00920,ko02010,map00920,map02010	M00185			ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3		ic_1306.c4869	Bacteria	1MUAU@1224,1RMAR@1236,COG1613@1,COG1613@2	NA|NA|NA	P	sulfate ABC transporter
C1_03700	155864.EDL933_5244	4e-181	640.6	Escherichia	pfkA	GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003872,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005945,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008443,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016043,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019003,GO:0019200,GO:0019318,GO:0019320,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032787,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035639,GO:0036094,GO:0042802,GO:0042866,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046031,GO:0046034,GO:0046365,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046835,GO:0046872,GO:0046939,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0061615,GO:0061695,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902494,GO:1990234	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019			iNRG857_1313.NRG857_19550	Bacteria	1MVN3@1224,1RMVY@1236,3XNE3@561,COG0205@1,COG0205@2	NA|NA|NA	F	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
C1_03701	155864.EDL933_5243	3.3e-161	574.3	Escherichia	fieF	GO:0000041,GO:0003674,GO:0005215,GO:0005381,GO:0005385,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006826,GO:0006829,GO:0006873,GO:0006875,GO:0006876,GO:0006882,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015086,GO:0015093,GO:0015291,GO:0015318,GO:0015341,GO:0015562,GO:0015684,GO:0015691,GO:0016020,GO:0019725,GO:0022804,GO:0022857,GO:0022883,GO:0022890,GO:0030001,GO:0030003,GO:0034220,GO:0034755,GO:0042592,GO:0042802,GO:0044464,GO:0046583,GO:0046873,GO:0046915,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0055065,GO:0055069,GO:0055073,GO:0055076,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0070574,GO:0070838,GO:0071577,GO:0071944,GO:0072503,GO:0072507,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:1903874		ko:K13283					ko00000,ko02000	2.A.4.7.1			Bacteria	1MUDS@1224,1RNS2@1236,3XN1Q@561,COG0053@1,COG0053@2	NA|NA|NA	P	Iron-efflux transporter responsible for iron detoxification. Also able to transport Zn(2 ) in a proton- dependent manner
C1_03702	155864.EDL933_5242	3.5e-80	304.3	Escherichia	cpxP	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0030288,GO:0030313,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031975,GO:0042597,GO:0042802,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051082,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K06006					ko00000,ko03110				Bacteria	1RIYB@1224,1S628@1236,3XPJN@561,COG3678@1,COG3678@2	NA|NA|NA	NPTU	overexpression decreases Cpx pathway activity. Some periplasmic stimulii (shown for P pili subunit PapE and probably 0.3 M NaCl) increase CpxP's susceptibility to DegP, leading to CpxP degradation, inducing the Cpx pathway. Aids in combating extracytoplasmic protein- mediated toxicity. Overexpression leads to degradation by DegP of misfolded P pili subunits in the periplasm (tested using PapE). Inhibits autophosphorylation of CpxA in reconstituted liposomes by 50 but has no effect on phosphatase activity of CpxA. Has mild protein chaperone activity
C1_03703	198214.SF3991	7e-127	459.9	Gammaproteobacteria													Bacteria	1MVCB@1224,1RMW7@1236,COG0745@1,COG0745@2	NA|NA|NA	K	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
C1_03704	199310.c4863	7e-256	889.4	Escherichia													Bacteria	1MUAK@1224,1RPDY@1236,3XPHK@561,COG0642@1,COG2205@2	NA|NA|NA	T	PhoQ Sensor
C1_03705	637910.ROD_00481	2.1e-161	575.1	Gammaproteobacteria	piv			ko:K07486					ko00000				Bacteria	1MXKJ@1224,1RSCP@1236,COG3547@1,COG3547@2	NA|NA|NA	L	Transposase
C1_03706	316407.85676149	1.1e-126	459.1	Escherichia	yiiM	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009636,GO:0009987,GO:0019748,GO:0042221,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0098754											Bacteria	1RAPM@1224,1RRB8@1236,3XMCD@561,COG2258@1,COG2258@2	NA|NA|NA	S	toxin catabolic process
C1_03707	198214.SF3986	2.1e-169	601.7	Gammaproteobacteria	kdgT	GO:0003674,GO:0005215,GO:0005342,GO:0005351,GO:0005402,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0008028,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0008643,GO:0015075,GO:0015077,GO:0015078,GO:0015144,GO:0015145,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015355,GO:0015649,GO:0015672,GO:0015711,GO:0015718,GO:0015749,GO:0015849,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0034219,GO:0034220,GO:0035429,GO:0042873,GO:0042879,GO:0044425,GO:0044464,GO:0046411,GO:0046942,GO:0046943,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:1902600,GO:1903825,GO:1905039		ko:K02526					ko00000,ko02000	2.A.10.1		iECH74115_1262.ECH74115_5364,iECSP_1301.ECSP_4972,iG2583_1286.G2583_4714,iUTI89_1310.UTI89_C4493	Bacteria	1MV01@1224,1RSNP@1236,28H7K@1,2Z7JT@2	NA|NA|NA	U	The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system
C1_03708	155864.EDL933_5236	6.4e-116	423.3	Escherichia	sodA	GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004784,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009266,GO:0009268,GO:0009408,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0010038,GO:0010269,GO:0010447,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0030145,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071241,GO:0071248,GO:0071291,GO:0071450,GO:0071451,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016				ko00000,ko00001,ko01000			iAF1260.b1656,iAPECO1_1312.APECO1_736,iB21_1397.B21_01616,iBWG_1329.BWG_1471,iE2348C_1286.E2348C_1742,iE2348C_1286.E2348C_4213,iEC042_1314.EC042_1825,iEC55989_1330.EC55989_1824,iECABU_c1320.ECABU_c19090,iECBD_1354.ECBD_1987,iECB_1328.ECB_01626,iECDH10B_1368.ECDH10B_1790,iECDH1ME8569_1439.ECDH1ME8569_1601,iECD_1391.ECD_01626,iECED1_1282.ECED1_1855,iECH74115_1262.ECH74115_2368,iECIAI1_1343.ECIAI1_1708,iECO103_1326.ECO103_1797,iECO111_1330.ECO111_2126,iECO26_1355.ECO26_2385,iECOK1_1307.ECOK1_1775,iECP_1309.ECP_1601,iECS88_1305.ECS88_1705,iECSE_1348.ECSE_1780,iECSF_1327.ECSF_3769,iECSP_1301.ECSP_2222,iECUMN_1333.ECUMN_1946,iECW_1372.ECW_m1823,iECs_1301.ECs2365,iEKO11_1354.EKO11_2118,iETEC_1333.ETEC_1691,iEcDH1_1363.EcDH1_1984,iEcE24377_1341.EcE24377A_1869,iEcHS_1320.EcHS_A1735,iEcSMS35_1347.EcSMS35_1542,iEcolC_1368.EcolC_1973,iG2583_1286.G2583_2051,iJO1366.b1656,iJR904.b1656,iLF82_1304.LF82_2148,iNRG857_1313.NRG857_08300,iSBO_1134.SBO_1475,iSDY_1059.SDY_1882,iSFV_1184.SFV_1678,iSF_1195.SF1684,iSFxv_1172.SFxv_1892,iSSON_1240.SSON_1500,iS_1188.S1816,iSbBS512_1146.SbBS512_E1853,iUMN146_1321.UM146_08870,iUMNK88_1353.UMNK88_2117,iUTI89_1310.UTI89_C1847,iWFL_1372.ECW_m1823,iY75_1357.Y75_RS08680,iZ_1308.Z2678,ic_1306.c2050	Bacteria	1MVW2@1224,1RP7X@1236,3XNVZ@561,COG0605@1,COG0605@2	NA|NA|NA	P	radicals which are normally produced within the cells and which are toxic to biological systems
C1_03709	34506.g4897	4.1e-192	677.2	Bilateria												iECSE_1348.ECSE_4196,iEcE24377_1341.EcE24377A_4438	Metazoa	2D1PQ@1,2SIT7@2759,3AD8R@33154,3BWTE@33208,3DDW1@33213	NA|NA|NA	S	L-rhamnose-proton symport protein (RhaT)
C1_03710	198214.SF3983	1.1e-178	632.5	Gammaproteobacteria	rhaR	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141		ko:K02854,ko:K02855					ko00000,ko03000				Bacteria	1QA56@1224,1RSI2@1236,COG1917@1,COG1917@2,COG4977@1,COG4977@2	NA|NA|NA	K	Activates expression of the rhaSR operon in response to L-rhamnose
C1_03711	316407.85676154	3.7e-159	567.4	Escherichia	rhaS	GO:0003674,GO:0003700,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141		ko:K02855					ko00000,ko03000				Bacteria	1Q7DC@1224,1RQ1U@1236,3XMYV@561,COG4977@1,COG4977@2	NA|NA|NA	K	Activates expression of the rhaBAD and rhaT operons
C1_03712	155864.EDL933_5230	7.2e-283	979.2	Escherichia	rhaB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0005996,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0008993,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0019200,GO:0019299,GO:0019301,GO:0019318,GO:0019320,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046365,GO:0046835,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901575	2.7.1.17,2.7.1.189,2.7.1.5,2.7.1.51,5.3.1.14	ko:K00848,ko:K00854,ko:K00879,ko:K01813,ko:K11216	ko00040,ko00051,ko01100,ko01120,ko02024,map00040,map00051,map01100,map01120,map02024	M00014	R01639,R01902,R02437,R03014,R03241,R11183	RC00002,RC00017,RC00434,RC00538	ko00000,ko00001,ko00002,ko01000			iEC55989_1330.EC55989_4019,iECIAI1_1343.ECIAI1_3729,iECO103_1326.ECO103_4670,iECO111_1330.ECO111_4384,iECO26_1355.ECO26_5037,iECSE_1348.ECSE_3838,iECSF_1327.ECSF_2594,iECW_1372.ECW_m3838,iEKO11_1354.EKO11_0162,iEcE24377_1341.EcE24377A_4435,iWFL_1372.ECW_m3838	Bacteria	1N51F@1224,1RQX6@1236,3XPCK@561,COG1070@1,COG1070@2	NA|NA|NA	F	Involved in the catabolism of L-rhamnose (6-deoxy-L- mannose). Catalyzes the transfer of the gamma-phosphate group from ATP to the 1-hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate
C1_03713	316407.85676156	4.3e-244	850.1	Escherichia	rhaA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0008270,GO:0008740,GO:0009056,GO:0009987,GO:0016043,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019299,GO:0019301,GO:0019318,GO:0019320,GO:0019321,GO:0019324,GO:0022607,GO:0030145,GO:0030246,GO:0032991,GO:0033296,GO:0036094,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0046872,GO:0046914,GO:0048029,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901575	2.7.1.5,5.3.1.14	ko:K00848,ko:K01813	ko00040,ko00051,ko01120,map00040,map00051,map01120		R01902,R02437,R03014	RC00002,RC00017,RC00434	ko00000,ko00001,ko01000			iECIAI39_1322.ECIAI39_3092,iUMNK88_1353.UMNK88_4739	Bacteria	1MW7Z@1224,1RPDX@1236,3XN9F@561,COG4806@1,COG4806@2	NA|NA|NA	G	L-rhamnose isomerase activity
C1_03714	316407.85676157	5.8e-157	560.1	Escherichia	rhaD	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006004,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008738,GO:0008742,GO:0008994,GO:0009056,GO:0009058,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0016853,GO:0016854,GO:0016857,GO:0019299,GO:0019301,GO:0019317,GO:0019318,GO:0019320,GO:0019321,GO:0019323,GO:0019324,GO:0019566,GO:0019568,GO:0019569,GO:0019571,GO:0019572,GO:0019637,GO:0019752,GO:0019852,GO:0042354,GO:0042355,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046372,GO:0046373,GO:0046872,GO:0046914,GO:0051167,GO:0051186,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901159,GO:1901575,GO:1901576	4.1.1.104,4.1.2.17,4.1.2.19,5.1.3.4	ko:K01628,ko:K01629,ko:K03077,ko:K22130	ko00040,ko00051,ko00053,ko01100,ko01120,map00040,map00051,map00053,map01100,map01120	M00550	R01785,R02262,R02263,R05850	RC00438,RC00599,RC00603,RC00604,RC01479	ko00000,ko00001,ko00002,ko01000			iECED1_1282.ECED1_3191,iECH74115_1262.ECH74115_5354,iECO111_1330.ECO111_4403,iECSP_1301.ECSP_4963,iECs_1301.ECs4829,iLF82_1304.LF82_1866,iNRG857_1313.NRG857_19475,iSDY_1059.SDY_4367,iSFV_1184.SFV_3593,iSSON_1240.SSON_0067,iSSON_1240.SSON_4072,iYL1228.KPN_04211,iZ_1308.Z5446,ic_1306.c4851	Bacteria	1MXV2@1224,1RP50@1236,3XP6R@561,COG0235@1,COG0235@2	NA|NA|NA	G	Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde
C1_03715	198214.SF3978	7.1e-55	219.5	Gammaproteobacteria	rhaM	GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009056,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019299,GO:0019301,GO:0019318,GO:0019320,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0071704,GO:1901575	5.1.3.32	ko:K03534			R10819	RC00563	ko00000,ko01000				Bacteria	1RGYV@1224,1S6AI@1236,COG3254@1,COG3254@2	NA|NA|NA	G	Involved in the anomeric conversion of L-rhamnose
C1_03716	469008.B21_03735	7.6e-252	875.9	Escherichia	lamB			ko:K02024					ko00000,ko02000	1.B.3.1.1			Bacteria	1R3B6@1224,1T65Z@1236,3XQX2@561,COG4580@1,COG4580@2	NA|NA|NA	G	Porin-like glycoporin RafY
C1_03717	316407.85676159	3.8e-78	297.4	Escherichia	frvA	GO:0001932,GO:0001934,GO:0003674,GO:0003824,GO:0004857,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0006810,GO:0006811,GO:0006820,GO:0008047,GO:0008150,GO:0008152,GO:0008643,GO:0009058,GO:0009059,GO:0009401,GO:0009893,GO:0009987,GO:0010033,GO:0010243,GO:0010467,GO:0010562,GO:0010604,GO:0015144,GO:0015711,GO:0015749,GO:0015791,GO:0015796,GO:0015849,GO:0015850,GO:0015882,GO:0016020,GO:0016021,GO:0016070,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019207,GO:0019209,GO:0019220,GO:0019222,GO:0019438,GO:0019887,GO:0022804,GO:0022857,GO:0022898,GO:0030234,GO:0030295,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031399,GO:0031401,GO:0032147,GO:0032268,GO:0032270,GO:0032409,GO:0032412,GO:0032774,GO:0032879,GO:0033674,GO:0034219,GO:0034220,GO:0034641,GO:0034645,GO:0034654,GO:0034762,GO:0034765,GO:0035461,GO:0042221,GO:0042325,GO:0042327,GO:0043085,GO:0043086,GO:0043170,GO:0043269,GO:0043549,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045859,GO:0045860,GO:0045937,GO:0046483,GO:0046942,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051049,GO:0051171,GO:0051173,GO:0051174,GO:0051179,GO:0051180,GO:0051181,GO:0051182,GO:0051234,GO:0051246,GO:0051247,GO:0051338,GO:0051347,GO:0051476,GO:0055085,GO:0060255,GO:0065007,GO:0065009,GO:0071702,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0090563,GO:0090581,GO:0090584,GO:0090585,GO:0097659,GO:0098656,GO:0098772,GO:1901264,GO:1901360,GO:1901362,GO:1901576,GO:1901656,GO:1901698,GO:1903825,GO:1905039	2.7.1.194,2.7.1.195,2.7.1.197,2.7.1.200,2.7.1.202,2.7.3.9	ko:K02768,ko:K02769,ko:K02770,ko:K02773,ko:K02798,ko:K02806,ko:K02821,ko:K08483,ko:K11189,ko:K11198,ko:K11199,ko:K11200,ko:K11201,ko:K18531	ko00051,ko00052,ko00053,ko01100,ko01120,ko02060,map00051,map00052,map00053,map01100,map01120,map02060	M00273,M00274,M00279,M00283,M00305,M00306,M00550	R02704,R03232,R05570,R07671,R11169	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1,4.A.2.1.12,4.A.2.1.2,4.A.2.1.24,4.A.2.1.3,4.A.2.1.5,4.A.5.1,4.A.7.1,8.A.7		iECABU_c1320.ECABU_c47530,iECUMN_1333.ECUMN_4728,iEcSMS35_1347.EcSMS35_4666,ic_1306.c5284	Bacteria	1RBJS@1224,1S2C8@1236,3XRDF@561,COG1762@1,COG1762@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FrvAB PTS system is involved in fructose transport
C1_03718	316407.85676160	1.3e-263	915.2	Escherichia	frvB	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090582	2.7.1.202	ko:K02768,ko:K02769,ko:K02770,ko:K11202,ko:K11203	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273,M00306	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1			Bacteria	1R5GJ@1224,1S19Y@1236,3XRKB@561,COG1299@1,COG1299@2,COG1445@1,COG1445@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FrvAB PTS system is involved in fructose transport
C1_03719	198214.SF3975	4.5e-202	710.3	Gammaproteobacteria	frvX			ko:K18530					ko00000,ko01000,ko01002				Bacteria	1MXEU@1224,1RYRZ@1236,COG1363@1,COG1363@2	NA|NA|NA	G	aminopeptidase
C1_03720	469008.B21_03731	0.0	1146.7	Gammaproteobacteria	frvR	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576	2.7.1.194,2.7.1.195,2.7.1.197,2.7.1.200,2.7.1.202,2.7.3.9	ko:K02538,ko:K02768,ko:K02769,ko:K02770,ko:K02773,ko:K02798,ko:K02806,ko:K02821,ko:K03483,ko:K08483,ko:K09685,ko:K11189,ko:K11198,ko:K11199,ko:K11200,ko:K11201,ko:K18531	ko00051,ko00052,ko00053,ko01100,ko01120,ko02060,map00051,map00052,map00053,map01100,map01120,map02060	M00273,M00274,M00279,M00283,M00305,M00306,M00550	R02704,R03232,R05570,R07671,R11169	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000,ko03000	4.A.2.1,4.A.2.1.12,4.A.2.1.2,4.A.2.1.24,4.A.2.1.3,4.A.2.1.5,4.A.5.1,4.A.7.1,8.A.7		iECIAI39_1322.ECIAI39_0923,iSbBS512_1146.SbBS512_E4725	Bacteria	1PIA1@1224,1S0BZ@1236,COG1762@1,COG1762@2,COG3711@1,COG3711@2	NA|NA|NA	GKT	Frv operon regulatory protein
C1_03721	316407.85676163	1.4e-187	662.1	Escherichia	yiiG												Bacteria	1RFF5@1224,1S3Y0@1236,2A2TX@1,30R7T@2,3XPFG@561	NA|NA|NA	S	Protein of unknown function (DUF3829)
C1_03722	316407.85676164	1.5e-155	555.4	Escherichia	fdhD	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0043085,GO:0043546,GO:0044093,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0050790,GO:0065007,GO:0065009,GO:0097159,GO:0097163,GO:0140104,GO:1901363		ko:K02379					ko00000				Bacteria	1NRU0@1224,1RNFH@1236,3XNWH@561,COG1526@1,COG1526@2	NA|NA|NA	J	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C1_03723	155864.EDL933_5218	1.6e-108	398.7	Escherichia	fdoG	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006464,GO:0006790,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009326,GO:0009987,GO:0015942,GO:0015944,GO:0015980,GO:0016043,GO:0016226,GO:0016491,GO:0016622,GO:0016903,GO:0016999,GO:0017144,GO:0018282,GO:0018289,GO:0018291,GO:0019538,GO:0019752,GO:0022607,GO:0031163,GO:0032787,GO:0032991,GO:0033554,GO:0036211,GO:0036397,GO:0042597,GO:0043170,GO:0043412,GO:0043436,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0047111,GO:0050896,GO:0051186,GO:0051716,GO:0052738,GO:0055114,GO:0071704,GO:0071840,GO:1901564,GO:1902494	1.17.1.9,1.17.5.3	ko:K00123,ko:K08348	ko00630,ko00680,ko01100,ko01120,ko01200,ko02020,map00630,map00680,map01100,map01120,map01200,map02020		R00519	RC02796	ko00000,ko00001,ko01000	5.A.3.2		iECW_1372.ECW_m4203,iECs_1301.ECs2078,iWFL_1372.ECW_m4203,iYL1228.KPN_04190,iZ_1308.Z2236	Bacteria	1MW3N@1224,1RN6N@1236,3XM6Z@561,COG0243@1,COG0243@2,COG3383@1,COG3383@2	NA|NA|NA	C	Formate dehydrogenase allows E.coli to use formate as major electron donor during anaerobic respiration, when nitrate is used as electron acceptor. The alpha subunit FdnG contains the formate oxidation site. Electrons are transferred from formate to menaquinone in the gamma subunit (FdnI), through the 4Fe-4S clusters in the beta subunit (FdnH). Formate dehydrogenase-N is part of a system that generates proton motive force, together with the dissimilatory nitrate reductase (Nar)
C1_03724	198214.SF3970	0.0	1678.3	Gammaproteobacteria	fdoG	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006464,GO:0006790,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009326,GO:0009987,GO:0015942,GO:0015944,GO:0015980,GO:0016043,GO:0016226,GO:0016491,GO:0016622,GO:0016903,GO:0016999,GO:0017144,GO:0018282,GO:0018289,GO:0018291,GO:0019538,GO:0019752,GO:0022607,GO:0031163,GO:0032787,GO:0032991,GO:0033554,GO:0036211,GO:0036397,GO:0042597,GO:0043170,GO:0043412,GO:0043436,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0047111,GO:0050896,GO:0051186,GO:0051716,GO:0052738,GO:0055114,GO:0071704,GO:0071840,GO:1901564,GO:1902494	1.17.1.9,1.17.5.3	ko:K00123,ko:K08348	ko00630,ko00680,ko01100,ko01120,ko01200,ko02020,map00630,map00680,map01100,map01120,map01200,map02020		R00519	RC02796	ko00000,ko00001,ko01000	5.A.3.2		iECW_1372.ECW_m4203,iECs_1301.ECs2078,iWFL_1372.ECW_m4203,iYL1228.KPN_04190,iZ_1308.Z2236	Bacteria	1MW3N@1224,1RN6N@1236,COG0243@1,COG0243@2,COG3383@1,COG3383@2	NA|NA|NA	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C1_03725	198214.SF3969	1.6e-179	635.2	Gammaproteobacteria	fdoH	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0008150,GO:0008152,GO:0009326,GO:0009898,GO:0009987,GO:0015942,GO:0015944,GO:0015980,GO:0016020,GO:0016491,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0031224,GO:0031226,GO:0031235,GO:0032787,GO:0032991,GO:0036397,GO:0043436,GO:0044237,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0052738,GO:0055114,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:1902494		ko:K00124,ko:K08349	ko00630,ko00680,ko01100,ko01120,ko01200,ko02020,map00630,map00680,map01100,map01120,map01200,map02020		R00519	RC02796	ko00000,ko00001	5.A.3.2		iAF1260.b3893,iAPECO1_1312.APECO1_2572,iB21_1397.B21_03727,iBWG_1329.BWG_3563,iEC042_1314.EC042_4267,iEC55989_1330.EC55989_4370,iECABU_c1320.ECABU_c43980,iECBD_1354.ECBD_4132,iECB_1328.ECB_03778,iECDH10B_1368.ECDH10B_4083,iECDH1ME8569_1439.ECDH1ME8569_3764,iECD_1391.ECD_03778,iECED1_1282.ECED1_4596,iECIAI1_1343.ECIAI1_4097,iECIAI39_1322.ECIAI39_3106,iECO103_1326.ECO103_4634,iECO26_1355.ECO26_4693,iECOK1_1307.ECOK1_4361,iECP_1309.ECP_1476,iECP_1309.ECP_4105,iECS88_1305.ECS88_4341,iECSE_1348.ECSE_4179,iECUMN_1333.ECUMN_4423,iECW_1372.ECW_m4202,iEKO11_1354.EKO11_4464,iEcDH1_1363.EcDH1_4091,iEcE24377_1341.EcE24377A_4422,iEcHS_1320.EcHS_A4121,iEcSMS35_1347.EcSMS35_4279,iEcolC_1368.EcolC_4125,iJO1366.b3893,iJR904.b3893,iLF82_1304.LF82_0634,iNRG857_1313.NRG857_19435,iSBO_1134.SBO_3907,iSFV_1184.SFV_3602,iSF_1195.SF3969,iSSON_1240.SSON_4062,iS_1188.S3779,iUMN146_1321.UM146_19695,iUMNK88_1353.UMNK88_4726,iUTI89_1310.UTI89_C4480,iWFL_1372.ECW_m4202,iY75_1357.Y75_RS17605,iYL1228.KPN_04189,ic_1306.c4843	Bacteria	1MU1B@1224,1RNFG@1236,COG0437@1,COG0437@2	NA|NA|NA	C	formate dehydrogenase
C1_03726	155864.EDL933_5216	8.6e-116	422.9	Escherichia	fdoI	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006091,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009326,GO:0009987,GO:0015942,GO:0015944,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0031224,GO:0031226,GO:0032787,GO:0032991,GO:0033554,GO:0036397,GO:0043436,GO:0044237,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0050896,GO:0051716,GO:0052738,GO:0055114,GO:0071704,GO:0071944,GO:1902494		ko:K00127,ko:K08350	ko00630,ko00680,ko01100,ko01120,ko01200,ko02020,map00630,map00680,map01100,map01120,map01200,map02020		R00519	RC02796	ko00000,ko00001	5.A.3.2		iEC042_1314.EC042_1608,iECED1_1282.ECED1_1627,iECNA114_1301.ECNA114_3649,iECSF_1327.ECSF_1390,iECUMN_1333.ECUMN_1730,ic_1306.c1907	Bacteria	1MXFQ@1224,1RNHH@1236,3XP33@561,COG2864@1,COG2864@2	NA|NA|NA	C	Allows to use formate as major electron donor during aerobic respiration. Subunit gamma is probably the cytochrome b556(FDO) component of the formate dehydrogenase
C1_03727	155864.EDL933_5215	1.7e-176	625.2	Escherichia	fdhE	GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006807,GO:0008150,GO:0008152,GO:0008199,GO:0009061,GO:0009987,GO:0010467,GO:0015980,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046872,GO:0046914,GO:0051604,GO:0055114,GO:0071704,GO:1901564		ko:K02380					ko00000				Bacteria	1NK06@1224,1RQC4@1236,3XMIZ@561,COG3058@1,COG3058@2	NA|NA|NA	O	Necessary for formate dehydrogenase activity
C1_03728	637910.ROD_00481	2.1e-161	575.1	Gammaproteobacteria	piv			ko:K07486					ko00000				Bacteria	1MXKJ@1224,1RSCP@1236,COG3547@1,COG3547@2	NA|NA|NA	L	Transposase
C1_03729	198214.SF3966	1e-37	162.2	Gammaproteobacteria	yiiF												Bacteria	1NJ8V@1224,1SH2N@1236,COG3905@1,COG3905@2	NA|NA|NA	K	Ribbon-helix-helix protein, copG family
C1_03730	155864.EDL933_5212	1e-31	142.1	Escherichia	yiiE												Bacteria	1QIPE@1224,1TGIQ@1236,3XR5Q@561,COG3905@1,COG3905@2	NA|NA|NA	K	regulation of nucleic acid-templated transcription
C1_03732	199310.c4838	1.2e-45	188.7	Gammaproteobacteria				ko:K07726					ko00000,ko03000				Bacteria	1MZGM@1224,1S97H@1236,COG2944@1,COG2944@2	NA|NA|NA	K	transcriptional regulator
C1_03733	199310.c4837	8.6e-53	212.6	Escherichia													Bacteria	1N7N5@1224,1S3WA@1236,3XR3G@561,COG4737@1,COG4737@2	NA|NA|NA	S	Cytotoxic translational repressor of toxin-antitoxin stability system
C1_03734	362663.ECP_4098	1.7e-173	615.1	Escherichia				ko:K01066					ko00000,ko01000				Bacteria	1NEXK@1224,1RNNH@1236,3XQU5@561,COG0657@1,COG0657@2	NA|NA|NA	I	alpha/beta hydrolase fold
C1_03735	155864.EDL933_5208	5.1e-181	640.2	Escherichia	yiiD	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006473,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0071704,GO:1901564		ko:K06323					ko00000				Bacteria	1R407@1224,1RPJ2@1236,3XP34@561,COG0454@1,COG0456@2	NA|NA|NA	K	protein acetylation
C1_03736	155864.EDL933_5207	1.1e-74	285.8	Escherichia	dtd	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106026,GO:0106074,GO:0140098,GO:0140101,GO:1901360		ko:K07560					ko00000,ko01000,ko03016				Bacteria	1RGTV@1224,1S61I@1236,3XNWE@561,COG1490@1,COG1490@2	NA|NA|NA	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
C1_03737	155864.EDL933_5206	4e-148	530.8	Escherichia	rbn	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K07058					ko00000				Bacteria	1QICW@1224,1RMKI@1236,3XN3U@561,COG1295@1,COG1295@2	NA|NA|NA	S	UPF0761 membrane protein YihY
C1_03738	198214.SF3957	7.8e-111	406.4	Gammaproteobacteria	yihX	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008877,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0030145,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050308	3.1.3.10	ko:K20866	ko00010,ko01120,map00010,map01120		R00947	RC00078	ko00000,ko00001,ko01000				Bacteria	1PGNF@1224,1RRDC@1236,COG1011@1,COG1011@2	NA|NA|NA	S	hydrolase
C1_03739	481805.EcolC_4134	3.8e-178	630.6	Escherichia	JD73_05665		5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000				Bacteria	1N5HJ@1224,1S9UC@1236,3XQC5@561,COG2017@1,COG2017@2	NA|NA|NA	G	Aldose 1-epimerase
C1_03740	481805.EcolC_4135	3.8e-254	883.6	Escherichia	GJ11_24635			ko:K03761,ko:K03762,ko:K08172,ko:K08173					ko00000,ko02000	2.A.1.6,2.A.1.6.2,2.A.1.6.4,2.A.1.6.6		e_coli_core.b2587,iAF1260.b2587,iAPECO1_1312.APECO1_1067,iB21_1397.B21_02445,iBWG_1329.BWG_2351,iEC55989_1330.EC55989_2218,iEC55989_1330.EC55989_2877,iECBD_1354.ECBD_1093,iECB_1328.ECB_02481,iECDH10B_1368.ECDH10B_2755,iECDH1ME8569_1439.ECDH1ME8569_2514,iECD_1391.ECD_02481,iECIAI1_1343.ECIAI1_2705,iECIAI39_1322.ECIAI39_2795,iECNA114_1301.ECNA114_2055,iECO103_1326.ECO103_3166,iECO111_1330.ECO111_3313,iECO26_1355.ECO26_3634,iECS88_1305.ECS88_2049,iECW_1372.ECW_m2816,iEKO11_1354.EKO11_1146,iETEC_1333.ETEC_2800,iEcDH1_1363.EcDH1_1081,iEcE24377_1341.EcE24377A_2873,iEcolC_1368.EcolC_1090,iJO1366.b2587,iJR904.b2587,iLF82_1304.LF82_2131,iNRG857_1313.NRG857_09945,iSBO_1134.SBO_2619,iSDY_1059.SDY_2830,iSF_1195.SF2649,iSFxv_1172.SFxv_2906,iSSON_1240.SSON_4052,iS_1188.S2822,iUMNK88_1353.UMNK88_3239,iUTI89_1310.UTI89_C4705,iWFL_1372.ECW_m2816,iY75_1357.Y75_RS13520,ic_1306.c5116	Bacteria	1MU46@1224,1RMF0@1236,3XPBU@561,COG0477@1,COG0477@2	NA|NA|NA	EGP	MFS/sugar transport protein
C1_03741	481805.EcolC_4136	1.1e-256	892.1	Escherichia	JD73_05655			ko:K08138					ko00000,ko02000	2.A.1.1.3		iECIAI1_1343.ECIAI1_4259,iECSE_1348.ECSE_4322	Bacteria	1N3I0@1224,1RQYP@1236,3XQDS@561,COG0477@1,COG0477@2	NA|NA|NA	EGP	MFS/sugar transport protein
C1_03742	481805.EcolC_4137	1.1e-189	669.1	Escherichia			1.1.1.303,1.1.1.4	ko:K00004	ko00650,map00650		R02855,R02946,R10504	RC00205,RC00525	ko00000,ko00001,ko01000				Bacteria	1R635@1224,1RRUW@1236,3XQ9A@561,COG1063@1,COG1063@2	NA|NA|NA	E	Alcohol dehydrogenase GroES-like domain
C1_03743	199310.c4827	3.2e-161	574.3	Escherichia	lacD	GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0006790,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016832,GO:0019637,GO:0034308,GO:0042180,GO:0044237,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0061595,GO:0061720,GO:0071704,GO:1901135,GO:1901136,GO:1901575,GO:1901615,GO:1902776,GO:1902777	4.1.2.40,4.1.2.57	ko:K01635,ko:K01671	ko00052,ko01100,ko02024,map00052,map01100,map02024		R01069,R10760	RC00438,RC00439	ko00000,ko00001,ko01000				Bacteria	1R4PC@1224,1T0SP@1236,3XRMM@561,COG3684@1,COG3684@2	NA|NA|NA	G	Cleaves 6-deoxy-6-sulfo-D-fructose 1-phosphate (SFP) to form dihydroxyacetone phosphate (DHAP) and 3-sulfolactaldehyde (SLA)
C1_03744	481805.EcolC_4139	6.2e-157	560.1	Escherichia	yihU	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006790,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009636,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019748,GO:0042221,GO:0042802,GO:0044237,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0047577,GO:0050896,GO:0055114,GO:0061596,GO:0071704,GO:0098754,GO:1901135,GO:1901136,GO:1901575,GO:1902776,GO:1902777	1.1.1.373,1.1.1.411,1.1.1.61	ko:K08318,ko:K08319	ko00650,ko01100,ko01200,map00650,map01100,map01200		R01644,R10719	RC00087,RC00099	ko00000,ko00001,ko01000			iBWG_1329.BWG_3552,iECDH10B_1368.ECDH10B_4072,iECDH1ME8569_1439.ECDH1ME8569_3753,iECO111_1330.ECO111_4702,iECO26_1355.ECO26_4708,iECW_1372.ECW_m4186,iEKO11_1354.EKO11_4480,iEcDH1_1363.EcDH1_4104,iJO1366.b3882,iSFV_1184.SFV_3617,iSF_1195.SF3954,iSFxv_1172.SFxv_4308,iS_1188.S3792,iWFL_1372.ECW_m4186,iY75_1357.Y75_RS17665	Bacteria	1RA7F@1224,1RMMY@1236,3XMX8@561,COG2084@1,COG2084@2	NA|NA|NA	I	Reduces 3-sulfolactaldehyde (SLA) to 2,3- dihydroxypropane 1-sulfonate (DHPS)
C1_03745	481805.EcolC_4140	6.8e-167	593.2	Escherichia	yihV	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006066,GO:0006082,GO:0006790,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0034308,GO:0042180,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044273,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046835,GO:0061594,GO:0061720,GO:0071704,GO:1901135,GO:1901136,GO:1901575,GO:1901615,GO:1902776,GO:1902777	2.7.1.15,2.7.1.184	ko:K00852,ko:K18478	ko00030,map00030		R01051,R02750,R10970	RC00002,RC00017	ko00000,ko00001,ko01000				Bacteria	1MWX4@1224,1RQW6@1236,3XPC4@561,COG0524@1,COG0524@2	NA|NA|NA	F	Phosphorylates 6-deoxy-6-sulfo-D-fructose (SF) to 6- deoxy-6-sulfo-D-fructose 1-phosphate (SFP)
C1_03746	481805.EcolC_4141	2.8e-140	504.6	Escherichia	yihW	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576											Bacteria	1MUJG@1224,1RQW5@1236,3XP99@561,COG1349@1,COG1349@2	NA|NA|NA	K	transcriptional regulator
C1_03747	199310.c4823	3.7e-235	820.5	Escherichia	yihN	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1MXUC@1224,1RRF8@1236,3XQBM@561,COG2271@1,COG2271@2	NA|NA|NA	P	transmembrane transport
C1_03748	316407.85676186	4e-181	640.6	Escherichia	yihM												Bacteria	1MY5W@1224,1RW4G@1236,3XQ67@561,COG1082@1,COG1082@2	NA|NA|NA	G	Xylose isomerase-like TIM barrel
C1_03749	155864.EDL933_5191	8.6e-133	479.6	Escherichia	yihL	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576		ko:K03710					ko00000,ko03000				Bacteria	1R4PN@1224,1RQ87@1236,3XQCK@561,COG2188@1,COG2188@2	NA|NA|NA	K	HTH-type transcriptional regulator YihL
C1_03750	155864.EDL933_5190	0.0	1196.8	Escherichia	typA	GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840		ko:K06207					ko00000				Bacteria	1MV5Q@1224,1RMJB@1236,3XNMS@561,COG1217@1,COG1217@2	NA|NA|NA	T	Probably interacts with the ribosomes in a GTP dependent manner
C1_03751	155864.EDL933_5189	9e-275	952.2	Escherichia	glnA	GO:0003674,GO:0003824,GO:0004356,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006541,GO:0006542,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009314,GO:0009628,GO:0009987,GO:0016053,GO:0016211,GO:0016853,GO:0016866,GO:0016874,GO:0016879,GO:0016880,GO:0019676,GO:0019740,GO:0019752,GO:0034022,GO:0042537,GO:0042802,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050486,GO:0050896,GO:0071704,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.4.4.3,6.3.1.2	ko:K01915,ko:K20712	ko00220,ko00250,ko00627,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00627,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727		R00253,R06988,R09284	RC00010,RC01754,RC02798	ko00000,ko00001,ko01000,ko04147			iJN746.PP_5046	Bacteria	1MUGQ@1224,1RMD1@1236,3XMQ8@561,COG0174@1,COG0174@2	NA|NA|NA	F	Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia
C1_03752	155864.EDL933_5188	9.9e-194	682.6	Escherichia	glnL	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019222,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0042578,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051716,GO:0065007,GO:0071704,GO:0140096,GO:1901564	2.7.13.3	ko:K07708,ko:K07710	ko02020,map02020	M00497,M00500			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	1MVN6@1224,1RN15@1236,3XNNN@561,COG3852@1,COG3852@2	NA|NA|NA	F	Member of the two-component regulatory system NtrB NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Under conditions of nitrogen limitation, NtrB autophosphorylates and transfers the phosphoryl group to NtrC. In the presence of nitrogen, acts as a phosphatase that dephosphorylates and inactivates NtrC
C1_03753	155864.EDL933_5187	2e-266	924.5	Escherichia	glnG	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043565,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141		ko:K07712	ko02020,map02020	M00497			ko00000,ko00001,ko00002,ko02022				Bacteria	1MU0N@1224,1RMCK@1236,3XNAJ@561,COG2204@1,COG2204@2	NA|NA|NA	T	Member of the two-component regulatory system NtrB NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter- sigma54-RNA polymerase complexes
C1_03754	362663.ECP_4078	1.2e-09	67.8	Gammaproteobacteria													Bacteria	1P8DX@1224,1SVWN@1236,2C785@1,2ZG52@2	NA|NA|NA		
C1_03755	155864.EDL933_5186	2.1e-268	931.0	Escherichia	hemN	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.98.3,2.1.1.342	ko:K02495,ko:K21936	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R06895,R11700	RC00884	ko00000,ko00001,ko00002,ko01000			iECIAI39_1322.ECIAI39_3134,iZ_1308.Z5403	Bacteria	1MV1I@1224,1RN1Y@1236,3XMD9@561,COG0635@1,COG0635@2	NA|NA|NA	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family
C1_03756	198214.SF3936	5.2e-63	247.3	Gammaproteobacteria	yihI	GO:0003674,GO:0005096,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008047,GO:0008150,GO:0030234,GO:0030695,GO:0043085,GO:0043087,GO:0043547,GO:0044087,GO:0044093,GO:0044424,GO:0044444,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051336,GO:0051345,GO:0060589,GO:0065007,GO:0065009,GO:0090069,GO:0090071,GO:0098772		ko:K09894					ko00000				Bacteria	1N8HM@1224,1SDUG@1236,COG3078@1,COG3078@2	NA|NA|NA	S	A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis
C1_03757	1440052.EAKF1_ch2082	9.8e-112	409.5	Escherichia	engB	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K03978					ko00000,ko03036				Bacteria	1MY3Z@1224,1RNJP@1236,3XN28@561,COG0218@1,COG0218@2	NA|NA|NA	D	Necessary for normal cell division and for the maintenance of normal septation
C1_03758	316407.85676195	0.0	1819.3	Escherichia	polA	GO:0000287,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004519,GO:0004520,GO:0004527,GO:0004536,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0017108,GO:0018130,GO:0019438,GO:0022616,GO:0030312,GO:0030955,GO:0031420,GO:0033554,GO:0033567,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0048256,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576	2.7.7.7	ko:K01146,ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440		R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400				Bacteria	1MU31@1224,1RNBG@1236,3XNHM@561,COG0258@1,COG0258@2,COG0749@1,COG0749@2	NA|NA|NA	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1_03759	469008.B21_03697	3.4e-177	627.5	Escherichia	yihG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1MVWG@1224,1RR21@1236,3XMIX@561,COG0204@1,COG0204@2	NA|NA|NA	I	transferase activity, transferring acyl groups
C1_03760	198214.SF3932	6.4e-268	929.5	Bacteria	ydgA												Bacteria	COG5339@1,COG5339@2	NA|NA|NA	S	identical protein binding
C1_03761	155864.EDL933_5175	1.2e-114	419.1	Escherichia	dsbA	GO:0003674,GO:0003756,GO:0003824,GO:0005575,GO:0005623,GO:0006457,GO:0008150,GO:0008152,GO:0009987,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071236,GO:0140096		ko:K03673	ko01503,map01503	M00728			ko00000,ko00001,ko00002,ko03110			iEcSMS35_1347.EcSMS35_4241	Bacteria	1RGWH@1224,1S5WA@1236,3XNYE@561,COG1651@1,COG1651@2	NA|NA|NA	O	Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB
C1_03762	155864.EDL933_5174	6e-193	679.9	Escherichia	srkA	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0071704,GO:0140096,GO:1901564											Bacteria	1MU2Q@1224,1RNHI@1236,3XNBG@561,COG2334@1,COG2334@2	NA|NA|NA	F	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C1_03763	1440052.EAKF1_ch2090c	7e-43	179.5	Escherichia	yihD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K09896					ko00000				Bacteria	1N026@1224,1S93G@1236,3XPVB@561,COG3084@1,COG3084@2	NA|NA|NA	S	Protein of unknown function (DUF1040)
C1_03764	481805.EcolC_4158	3e-107	394.4	Escherichia	mobA	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019538,GO:0019637,GO:0019720,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061603,GO:0070568,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902757,GO:1902758	2.10.1.1,2.7.7.77	ko:K03750,ko:K03752,ko:K13818	ko00790,ko01100,map00790,map01100		R09735,R11581	RC03462	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_2604,iEcHS_1320.EcHS_A4080,iEcolC_1368.EcolC_4158,iLF82_1304.LF82_1370,iNRG857_1313.NRG857_19230,iSBO_1134.SBO_3869,iSbBS512_1146.SbBS512_E4329,iUMNK88_1353.UMNK88_4686,ic_1306.c4801	Bacteria	1RH3M@1224,1S74N@1236,3XPN6@561,COG0746@1,COG0746@2	NA|NA|NA	F	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor
C1_03765	469008.B21_03691	2.9e-93	347.8	Escherichia	mobB	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	2.10.1.1,2.7.7.77	ko:K02379,ko:K03750,ko:K03752,ko:K03753,ko:K13818	ko00790,ko01100,map00790,map01100		R09735,R11581	RC03462	ko00000,ko00001,ko01000			iB21_1397.B21_03691,iBWG_1329.BWG_3527,iECBD_1354.ECBD_4174,iECDH1ME8569_1439.ECDH1ME8569_3728,iEcDH1_1363.EcDH1_4130,iJO1366.b3856,iSbBS512_1146.SbBS512_E4328,iY75_1357.Y75_RS17805	Bacteria	1RD3Q@1224,1S72P@1236,3XNU6@561,COG1763@1,COG1763@2	NA|NA|NA	H	GTP-binding protein that is not required for the biosynthesis of Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor, and not necessary for the formation of active molybdoenzymes using this form of molybdenum cofactor. May act as an adapter protein to achieve the efficient biosynthesis and utilization of MGD. Displays a weak intrinsic GTPase activity. Is also able to bind the nucleotides ATP, TTP and GDP, but with lower affinity than GTP
C1_03771	198214.SF3926	5.7e-100	370.2	Gammaproteobacteria	hemG	GO:0000166,GO:0003674,GO:0003824,GO:0004729,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0010181,GO:0016491,GO:0016627,GO:0016634,GO:0016635,GO:0018130,GO:0019438,GO:0032553,GO:0033013,GO:0033014,GO:0034641,GO:0036094,GO:0042168,GO:0042440,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0070818,GO:0070819,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000			iAF1260.b3850,iAF987.Gmet_2953,iAPECO1_1312.APECO1_2607,iB21_1397.B21_03690,iBWG_1329.BWG_3526,iE2348C_1286.E2348C_4162,iECABU_c1320.ECABU_c43520,iECBD_1354.ECBD_4175,iECB_1328.ECB_03741,iECDH10B_1368.ECDH10B_4039,iECDH1ME8569_1439.ECDH1ME8569_3727,iECD_1391.ECD_03741,iECED1_1282.ECED1_4552,iECH74115_1262.ECH74115_5289,iECIAI1_1343.ECIAI1_4043,iECNA114_1301.ECNA114_4159,iECOK1_1307.ECOK1_4319,iECS88_1305.ECS88_4298,iECSF_1327.ECSF_3707,iECSP_1301.ECSP_4903,iECs_1301.ECs4778,iEcDH1_1363.EcDH1_4131,iEcHS_1320.EcHS_A4073,iEcolC_1368.EcolC_4160,iG2583_1286.G2583_4648,iJO1366.b3850,iJR904.b3850,iLF82_1304.LF82_0981,iNRG857_1313.NRG857_19220,iSDY_1059.SDY_3895,iUMN146_1321.UM146_19505,iUMNK88_1353.UMNK88_4678,iUTI89_1310.UTI89_C4435,iY75_1357.Y75_RS17835,iZ_1308.Z5372,ic_1306.c4797	Bacteria	1RAH2@1224,1S372@1236,COG4635@1,COG4635@2	NA|NA|NA	CH	Protoporphyrinogen oxidase
C1_03772	155864.EDL933_5169	1.3e-273	948.3	Escherichia	trkH	GO:0003674,GO:0005215,GO:0005216,GO:0005261,GO:0005267,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015267,GO:0015318,GO:0015672,GO:0016020,GO:0016021,GO:0022803,GO:0022838,GO:0022857,GO:0022890,GO:0030001,GO:0030955,GO:0031224,GO:0031226,GO:0031420,GO:0034220,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0046983,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098660,GO:0098662		ko:K03498,ko:K03499					ko00000,ko02000	2.A.38.1,2.A.38.4		iPC815.YPO3762,iSFV_1184.SFV_3651	Bacteria	1MUIJ@1224,1RMN6@1236,3XMVE@561,COG0168@1,COG0168@2	NA|NA|NA	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA
C1_03773	316407.85676205	1.5e-109	402.1	Escherichia	yigZ		2.1.1.45,3.4.13.9	ko:K00560,ko:K01271	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000,ko01002				Bacteria	1NFJC@1224,1RPBF@1236,3XNVA@561,COG1739@1,COG1739@2	NA|NA|NA	S	Uncharacterized protein family UPF0029
C1_03774	316407.85676206	1e-264	918.7	Escherichia	pepQ	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009056,GO:0009987,GO:0016787,GO:0016805,GO:0019538,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0070573,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271					ko00000,ko01000,ko01002				Bacteria	1MURT@1224,1RMKT@1236,3XM9C@561,COG0006@1,COG0006@2	NA|NA|NA	E	Splits dipeptides with a prolyl residue in the C- terminal position
C1_03775	316407.85676207	0.0	1441.4	Escherichia	fadB	GO:0003674,GO:0003824,GO:0003857,GO:0004165,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0006725,GO:0006805,GO:0008150,GO:0008152,GO:0008691,GO:0008692,GO:0009056,GO:0009062,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016042,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016856,GO:0016860,GO:0016863,GO:0019395,GO:0019439,GO:0019748,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0098754,GO:1901360,GO:1901361,GO:1901575	1.1.1.157,1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8	ko:K00074,ko:K01782,ko:K01825	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R01976,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R04756,R05066,R05305,R05576,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01078,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000			iECO103_1326.ECO103_1532,iETEC_1333.ETEC_2476,iLF82_1304.LF82_0614,iNRG857_1313.NRG857_19200	Bacteria	1MU9P@1224,1RMZ8@1236,3XMBN@561,COG1024@1,COG1024@2,COG1250@1,COG1250@2	NA|NA|NA	I	Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate
C1_03776	481805.EcolC_4165	1.6e-216	758.4	Escherichia	fadA	GO:0003674,GO:0003824,GO:0003988,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	2.3.1.16	ko:K00632	ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212	M00087,M00113	R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_2612,iECNA114_1301.ECNA114_4154,iECOK1_1307.ECOK1_4314,iECP_1309.ECP_4058,iECS88_1305.ECS88_4293,iECSF_1327.ECSF_3702,iEcE24377_1341.EcE24377A_4364,iLF82_1304.LF82_0613,iNRG857_1313.NRG857_19195,iPC815.YPO3767	Bacteria	1MU5G@1224,1RM93@1236,3XM40@561,COG0183@1,COG0183@2	NA|NA|NA	I	Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed
C1_03777	155864.EDL933_5164	2e-129	468.4	Escherichia	fre	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006807,GO:0006950,GO:0006979,GO:0008047,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0019538,GO:0030091,GO:0030234,GO:0042602,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0050896,GO:0052875,GO:0055114,GO:0065007,GO:0065009,GO:0071704,GO:0098772,GO:1901564	1.16.1.3,1.17.1.1,1.5.1.41	ko:K00523,ko:K02823,ko:K05368,ko:K18248,ko:K20256	ko00240,ko00520,ko00627,ko00740,ko00860,ko01100,ko01120,ko02024,map00240,map00520,map00627,map00740,map00860,map01100,map01120,map02024	M00637	R00097,R00823,R00825,R03391,R03392,R05705	RC00126,RC00192,RC00220,RC00230	br01602,ko00000,ko00001,ko00002,ko01000			iSF_1195.SF3920,iSFxv_1172.SFxv_4273,iS_1188.S3832	Bacteria	1MV72@1224,1RPH5@1236,3XPH0@561,COG0543@1,COG0543@2	NA|NA|NA	C	Catalyzes the reduction of soluble flavins by reduced pyridine nucleotides. Seems to reduce the complexed Fe(3 ) iron of siderophores to Fe(2 ), thus releasing it from the chelator
C1_03778	199310.c4790	6.6e-300	1035.8	Escherichia	ubiD	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008694,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	4.1.1.61,4.1.1.98	ko:K03182,ko:K16239	ko00130,ko00627,ko01100,ko01110,ko01120,map00130,map00627,map01100,map01110,map01120	M00117	R01238,R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000			iECO111_1330.ECO111_4669,iIT341.HP0396	Bacteria	1MU62@1224,1RNH8@1236,3XMYJ@561,COG0043@1,COG0043@2	NA|NA|NA	H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis
C1_03779	155864.EDL933_5162	1.7e-87	328.6	Escherichia	rfaH	GO:0001000,GO:0001073,GO:0001121,GO:0001124,GO:0003674,GO:0003676,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006354,GO:0006355,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008494,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031554,GO:0031564,GO:0032268,GO:0032270,GO:0032774,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045182,GO:0045727,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090079,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141		ko:K02601,ko:K05785					ko00000,ko03000,ko03009,ko03021				Bacteria	1N01W@1224,1S91B@1236,3XM7J@561,COG0250@1,COG0250@2	NA|NA|NA	K	Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components. RfaH is recruited into a multi-component RNA polymerase complex by the ops element, which is a short conserved DNA sequence located downstream of the main promoter of these operons. Once bound, RfaH suppresses pausing and inhibits Rho- dependent and intrinsic termination at a subset of sites. Termination signals are bypassed, which allows complete synthesis of long RNA chains
C1_03780	198214.SF3917	3.3e-149	534.3	Gammaproteobacteria	tatD	GO:0000175,GO:0000302,GO:0000738,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004532,GO:0004536,GO:0004540,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0009056,GO:0009057,GO:0009636,GO:0009987,GO:0010035,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0042221,GO:0042493,GO:0042542,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046700,GO:0046872,GO:0050896,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140097,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901700		ko:K03424					ko00000,ko01000				Bacteria	1MXN8@1224,1RNCC@1236,COG0084@1,COG0084@2	NA|NA|NA	L	3'-5' exonuclease that prefers single-stranded DNA and RNA. May play a role in the H(2)O(2)-induced DNA damage repair
C1_03781	155864.EDL933_5160	1e-131	476.1	Escherichia	tatC	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009314,GO:0009628,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0050896,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680		ko:K03118	ko03060,ko03070,map03060,map03070	M00336			ko00000,ko00001,ko00002,ko02044	2.A.64			Bacteria	1MVAY@1224,1RPRN@1236,3XPGT@561,COG0805@1,COG0805@2	NA|NA|NA	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides
C1_03782	155864.EDL933_5159	1.6e-80	305.4	Escherichia	tatB	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680		ko:K03116,ko:K03117	ko03060,ko03070,map03060,map03070	M00336			ko00000,ko00001,ko00002,ko02044	2.A.64			Bacteria	1N73F@1224,1SD9K@1236,3XP1U@561,COG1826@1,COG1826@2	NA|NA|NA	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation
C1_03783	155864.EDL933_5158	8.8e-38	162.5	Escherichia	tatA	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680		ko:K03116,ko:K03425	ko03060,ko03070,map03060,map03070	M00336			ko00000,ko00001,ko00002,ko02044	2.A.64			Bacteria	1N6S4@1224,1SCC7@1236,3XPXZ@561,COG1826@1,COG1826@2	NA|NA|NA	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
C1_03784	155864.EDL933_5157	0.0	1110.5	Escherichia	ubiB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663		ko:K03688					ko00000			iYL1228.KPN_04331	Bacteria	1MU1Z@1224,1RNQM@1236,3XNRF@561,COG0661@1,COG0661@2	NA|NA|NA	H	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C1_03785	198214.SF3912	5e-105	387.1	Gammaproteobacteria	yigP	GO:0006082,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0019752,GO:0032150,GO:0042180,GO:0042181,GO:0043436,GO:0043648,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046417,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663		ko:K03690					ko00000				Bacteria	1R1CM@1224,1S745@1236,COG3165@1,COG3165@2	NA|NA|NA	S	protein conserved in bacteria
C1_03786	1440052.EAKF1_ch2109c	3.5e-140	504.2	Escherichia	ubiE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008425,GO:0008757,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0030580,GO:0032259,GO:0040007,GO:0042180,GO:0042181,GO:0043333,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000			iAF1260.b3833,iBWG_1329.BWG_3511,iE2348C_1286.E2348C_4147,iEC042_1314.EC042_4213,iEC55989_1330.EC55989_4310,iECDH10B_1368.ECDH10B_4024,iECDH1ME8569_1439.ECDH1ME8569_3712,iECH74115_1262.ECH74115_5274,iECIAI1_1343.ECIAI1_4028,iECIAI39_1322.ECIAI39_3162,iECO103_1326.ECO103_4330,iECO111_1330.ECO111_4661,iECO26_1355.ECO26_4752,iECSE_1348.ECSE_4121,iECSP_1301.ECSP_4888,iECUMN_1333.ECUMN_4359,iECW_1372.ECW_m4135,iECs_1301.ECs4763,iEKO11_1354.EKO11_4524,iETEC_1333.ETEC_4110,iEcDH1_1363.EcDH1_4146,iEcE24377_1341.EcE24377A_4354,iEcHS_1320.EcHS_A4057,iEcSMS35_1347.EcSMS35_4216,iEcolC_1368.EcolC_4175,iG2583_1286.G2583_4633,iJO1366.b3833,iJR904.b3833,iSBO_1134.SBO_3847,iSDY_1059.SDY_3910,iSFV_1184.SFV_3665,iSF_1195.SF3911,iSFxv_1172.SFxv_4263,iSSON_1240.SSON_4008,iS_1188.S3843,iSbBS512_1146.SbBS512_E4305,iUMNK88_1353.UMNK88_4663,iWFL_1372.ECW_m4135,iY75_1357.Y75_RS17910,iZ_1308.Z5355	Bacteria	1MX8I@1224,1RMAU@1236,3XNXR@561,COG0500@1,COG2226@2	NA|NA|NA	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)
C1_03787	155864.EDL933_5154	3.9e-257	893.6	Escherichia	rmuC	GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:1901360		ko:K09760					ko00000				Bacteria	1MWHV@1224,1RMB8@1236,3XMJN@561,COG1322@1,COG1322@2	NA|NA|NA	S	DNA recombination protein RmuC
C1_03788	155864.EDL933_5153	5.6e-138	496.9	Escherichia	udp	GO:0003674,GO:0003824,GO:0004850,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006218,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009116,GO:0009119,GO:0009164,GO:0009987,GO:0016043,GO:0016740,GO:0016757,GO:0016763,GO:0019439,GO:0022607,GO:0030955,GO:0031420,GO:0033554,GO:0034214,GO:0034641,GO:0034655,GO:0034656,GO:0042454,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046108,GO:0046131,GO:0046133,GO:0046135,GO:0046483,GO:0046700,GO:0046872,GO:0050896,GO:0051259,GO:0051716,GO:0055086,GO:0065003,GO:0071704,GO:0071840,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658	2.4.2.3	ko:K00757	ko00240,ko00983,ko01100,map00240,map00983,map01100		R01876,R02484,R08229	RC00063	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_2630,iB21_1397.B21_03667,iECABU_c1320.ECABU_c43290,iECBD_1354.ECBD_4198,iECB_1328.ECB_03718,iECD_1391.ECD_03718,iECNA114_1301.ECNA114_4136,iECOK1_1307.ECOK1_4296,iECP_1309.ECP_4040,iECS88_1305.ECS88_4275,iECSF_1327.ECSF_3683,iEcSMS35_1347.EcSMS35_4208,iLF82_1304.LF82_2357,iNRG857_1313.NRG857_19105,iUMN146_1321.UM146_19385,iUMNK88_1353.UMNK88_4655	Bacteria	1P0EC@1224,1RN3N@1236,3XN82@561,COG2820@1,COG2820@2	NA|NA|NA	F	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
C1_03789	198214.SF3908	9.2e-155	552.7	Gammaproteobacteria	ysgA		3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130		R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000				Bacteria	1MW7S@1224,1RPGK@1236,COG0412@1,COG0412@2	NA|NA|NA	Q	Dienelactone hydrolase
C1_03790	481805.EcolC_4179	0.0	1528.1	Escherichia	metE	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003871,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0030312,GO:0032259,GO:0034641,GO:0035999,GO:0036211,GO:0040007,GO:0042084,GO:0042085,GO:0042558,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0050667,GO:0051186,GO:0071704,GO:0071944,GO:0140096,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000			iE2348C_1286.E2348C_4130,iECO103_1326.ECO103_4334,iECO111_1330.ECO111_4657,iECO26_1355.ECO26_4756,iECW_1372.ECW_m4131,iEKO11_1354.EKO11_4528,iPC815.YPO3788,iWFL_1372.ECW_m4131	Bacteria	1MUI9@1224,1RMBA@1236,3XP3E@561,COG0620@1,COG0620@2	NA|NA|NA	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C1_03791	362663.ECP_4022	4.3e-180	637.1	Escherichia	metR	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016597,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031406,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141		ko:K03576					ko00000,ko03000				Bacteria	1MUIX@1224,1RRF3@1236,3XPAG@561,COG0583@1,COG0583@2	NA|NA|NA	K	MetR is a positive activator of the metA, metE and metH genes
C1_03792	316407.85676224	2.3e-167	594.7	Escherichia	yigM	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1MWMC@1224,1RQST@1236,3XP2T@561,COG0697@1,COG0697@2	NA|NA|NA	EG	EamA-like transporter family
C1_03793	362663.ECP_4020	1.2e-151	542.3	Escherichia	yigL	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0033883,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0050308		ko:K11938					ko00000,ko01000			iEC55989_1330.EC55989_0460,iECO111_1330.ECO111_0479,iECO26_1355.ECO26_0481,iUTI89_1310.UTI89_C4390	Bacteria	1MV02@1224,1RP1D@1236,3XMVF@561,COG0561@1,COG0561@2	NA|NA|NA	S	Catalyzes Strongly the dephosphorylation of pyridoxal- phosphate (PLP) and moderately the dephosphorylation of 2- deoxyglucose 6-phosphate (2bGLU6P) and beta-glucose 6-phosphate (bGlu6P). Also hydrolyzes both purines (GMP and IMP) and pyrimidines as secondary substrates
C1_03794	199310.c4747	5.1e-203	713.4	Escherichia	pldB	GO:0003674,GO:0003824,GO:0004620,GO:0004622,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0008150,GO:0008152,GO:0016020,GO:0016298,GO:0016740,GO:0016746,GO:0016747,GO:0016787,GO:0016788,GO:0044238,GO:0044464,GO:0052689,GO:0071704,GO:0071944	3.1.1.5	ko:K01048	ko00564,map00564				ko00000,ko00001,ko01000			iETEC_1333.ETEC_4102,iEcHS_1320.EcHS_A4049	Bacteria	1MWDA@1224,1RRJP@1236,3XMJA@561,COG2267@1,COG2267@2	NA|NA|NA	I	Lysophospholipase L2
C1_03795	155864.EDL933_5146	7.9e-106	389.8	Escherichia	rhtB	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015175,GO:0015179,GO:0015318,GO:0015711,GO:0015804,GO:0015807,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0042968,GO:0042970,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:1902475,GO:1903825,GO:1905039		ko:K05834					ko00000,ko02000	2.A.76.1.1		iECIAI39_1322.ECIAI39_3185	Bacteria	1MXAI@1224,1RPWN@1236,3XNZJ@561,COG1280@1,COG1280@2	NA|NA|NA	E	Conducts the efflux of homoserine and homoserine lactone
C1_03796	469008.B21_03651	1.2e-109	402.5	Escherichia	rhtC	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015175,GO:0015179,GO:0015318,GO:0015711,GO:0015804,GO:0015807,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0042968,GO:0042970,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:1902475,GO:1903825,GO:1905039		ko:K05835					ko00000,ko02000	2.A.76.1.2			Bacteria	1MX0K@1224,1RP43@1236,3XP86@561,COG1280@1,COG1280@2	NA|NA|NA	E	Threonine efflux protein
C1_03797	155864.EDL933_5144	0.0	1221.8	Escherichia	recQ	GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008270,GO:0009295,GO:0009378,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017116,GO:0017117,GO:0030894,GO:0032392,GO:0032508,GO:0032991,GO:0032993,GO:0033202,GO:0033554,GO:0034641,GO:0042623,GO:0043138,GO:0043140,GO:0043142,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1904949	3.6.4.12	ko:K03654	ko03018,map03018				ko00000,ko00001,ko01000,ko03400				Bacteria	1MVGG@1224,1RMPG@1236,3XNKI@561,COG0514@1,COG0514@2	NA|NA|NA	L	ATP-dependent DNA helicase
C1_03798	155864.EDL933_5143	9.8e-171	605.9	Escherichia	pldA	GO:0003674,GO:0003824,GO:0004620,GO:0004623,GO:0005488,GO:0005509,GO:0005515,GO:0005575,GO:0005623,GO:0008970,GO:0009279,GO:0016020,GO:0016021,GO:0016298,GO:0016787,GO:0016788,GO:0019867,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031975,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044425,GO:0044462,GO:0044464,GO:0045203,GO:0046872,GO:0046983,GO:0052689,GO:0071944	3.1.1.32,3.1.1.4	ko:K01058	ko00564,ko00565,ko00590,ko00591,ko00592,ko01100,ko01110,map00564,map00565,map00590,map00591,map00592,map01100,map01110		R01315,R01316,R01317,R02053,R02054,R04034,R07064,R07379,R07387,R07859,R07860	RC00020,RC00037,RC00041,RC00094	ko00000,ko00001,ko01000			iEC042_1314.EC042_4201,iECUMN_1333.ECUMN_4347,iEcSMS35_1347.EcSMS35_4188	Bacteria	1PC8I@1224,1RMJH@1236,3XM7B@561,COG2829@1,COG2829@2	NA|NA|NA	M	hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities
C1_03799	155864.EDL933_5142	7.3e-80	303.1	Escherichia	yigI	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Bacteria	1N5HF@1224,1RNAK@1236,3XPAZ@561,COG2050@1,COG2050@2	NA|NA|NA	Q	Thioesterase superfamily
C1_03800	155864.EDL933_5141	6.1e-160	570.1	Escherichia	rarD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016021,GO:0031224,GO:0044425,GO:0044464,GO:0071944		ko:K05786					ko00000,ko02000	2.A.7.7			Bacteria	1MX5G@1224,1RMAC@1236,3XP4W@561,COG2962@1,COG2962@2	NA|NA|NA	S	EamA-like transporter family
C1_03803	469008.B21_03643	6.6e-90	336.7	Escherichia	lytH			ko:K06401,ko:K21472					ko00000,ko01000,ko01002,ko01011				Bacteria	1R8BV@1224,1RZI2@1236,3XR0R@561,COG0739@1,COG0739@2	NA|NA|NA	M	Protein of unknown function (DUF3289)
C1_03804	155864.EDL933_5137	3.8e-92	344.0	Escherichia													Bacteria	1N22B@1224,1SBN5@1236,2E0YA@1,32WEU@2,3XRDP@561	NA|NA|NA	S	Enterobacterial putative membrane protein (DUF943)
C1_03805	155864.EDL933_5136	1.8e-173	615.1	Escherichia	corA	GO:0000041,GO:0003674,GO:0005215,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0008150,GO:0008324,GO:0015075,GO:0015087,GO:0015095,GO:0015099,GO:0015318,GO:0015675,GO:0015693,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035444,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:1903830		ko:K03284,ko:K16074					ko00000,ko02000	1.A.35.1,1.A.35.3,1.A.35.4		iAF987.Gmet_0134,iYL1228.KPN_04313	Bacteria	1MWMP@1224,1RNDQ@1236,3XN9J@561,COG0598@1,COG0598@2	NA|NA|NA	P	Mediates influx of magnesium ions
C1_03806	155864.EDL933_5134	3.6e-137	494.2	Escherichia	yigE												Bacteria	1NH9S@1224,1RNWS@1236,3XNYD@561,COG3698@1,COG3698@2	NA|NA|NA	S	Phosphodiester glycosidase
C1_03807	155864.EDL933_5132	0.0	1442.6	Escherichia	uvrD	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006289,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017116,GO:0022607,GO:0031297,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0042802,GO:0043142,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045005,GO:0046483,GO:0050896,GO:0051259,GO:0051260,GO:0051276,GO:0051716,GO:0065003,GO:0070035,GO:0070581,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	3.6.4.12	ko:K03656,ko:K03657	ko03420,ko03430,map03420,map03430				ko00000,ko00001,ko01000,ko03400				Bacteria	1MU0G@1224,1RNJI@1236,3XPBA@561,COG0210@1,COG0210@2	NA|NA|NA	L	A helicase with DNA-dependent ATPase activity. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand. Initiates unwinding more efficiently from a nicked substrate than ds duplex DNA. Involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair, and probably also in repair of alkylated DNA
C1_03808	198214.SF3890	3.9e-133	480.7	Gammaproteobacteria	yigB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0017144,GO:0018130,GO:0022611,GO:0032502,GO:0034641,GO:0042364,GO:0042578,GO:0042726,GO:0042727,GO:0043167,GO:0043169,GO:0043726,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.1.3.10,3.1.3.102,3.1.3.104	ko:K07025,ko:K20862,ko:K20866	ko00010,ko00740,ko01100,ko01110,ko01120,map00010,map00740,map01100,map01110,map01120	M00125	R00548,R00947,R07280	RC00017,RC00078	ko00000,ko00001,ko00002,ko01000				Bacteria	1N0I6@1224,1RQ41@1236,COG1011@1,COG1011@2	NA|NA|NA	S	Hydrolase
C1_03809	198214.SF3889	6.1e-168	596.7	Gammaproteobacteria	xerC	GO:0000150,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009987,GO:0015074,GO:0032991,GO:0034641,GO:0042150,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0071139,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363		ko:K03733					ko00000,ko03036				Bacteria	1MUJJ@1224,1RMJG@1236,COG4973@1,COG4973@2	NA|NA|NA	D	Belongs to the 'phage' integrase family. XerC subfamily
C1_03810	316407.85676240	2.9e-128	464.5	Escherichia	yigA			ko:K09921					ko00000				Bacteria	1R4BP@1224,1S9SC@1236,3XNG2@561,COG3159@1,COG3159@2	NA|NA|NA	S	Protein of unknown function, DUF484
C1_03811	155864.EDL933_5128	5.8e-157	560.1	Escherichia	dapF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000			iECED1_1282.ECED1_4494	Bacteria	1MWDH@1224,1RMGV@1236,3XP2D@561,COG0253@1,COG0253@2	NA|NA|NA	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C1_03812	155864.EDL933_5127	1.3e-30	138.3	Escherichia	yifL												Bacteria	1N70H@1224,1SDC8@1236,3XPYT@561,COG5567@1,COG5567@2	NA|NA|NA	N	Prokaryotic lipoprotein-attachment site
C1_03813	1410619.SRDD_12330	2.1e-57	228.8	Gammaproteobacteria													Bacteria	1RCE7@1224,1S2J0@1236,28RND@1,2ZE13@2	NA|NA|NA	S	Protein involved in biological_process
C1_03814	199310.c4728	1.2e-261	908.7	Escherichia													Bacteria	1R9A3@1224,1RS8S@1236,28M3A@1,2ZAHK@2,3XNER@561	NA|NA|NA		
C1_03815	199310.c4727	5.7e-239	833.2	Escherichia													Bacteria	1R9A3@1224,1RS8S@1236,28M3A@1,2ZAHK@2,3XNER@561	NA|NA|NA		
C1_03816	316407.85676244	7e-58	229.6	Escherichia	cyaY	GO:0003674,GO:0003824,GO:0004322,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006790,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008198,GO:0008199,GO:0009987,GO:0016043,GO:0016226,GO:0016491,GO:0016530,GO:0016722,GO:0016724,GO:0018282,GO:0018283,GO:0019538,GO:0019725,GO:0022607,GO:0030003,GO:0031163,GO:0033554,GO:0034599,GO:0034986,GO:0036211,GO:0042221,GO:0042592,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0050896,GO:0051186,GO:0051536,GO:0051537,GO:0051540,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071704,GO:0071840,GO:0098771,GO:0140104,GO:1901564	1.16.3.1	ko:K06202,ko:K19054	ko00860,map00860		R00078	RC02758	ko00000,ko00001,ko01000,ko03029			iECW_1372.ECW_m4108,iEKO11_1354.EKO11_4552,iWFL_1372.ECW_m4108	Bacteria	1RH9A@1224,1S5UP@1236,3XPP1@561,COG1965@1,COG1965@2	NA|NA|NA	P	Belongs to the frataxin family
C1_03817	155864.EDL933_5124	0.0	1735.7	Escherichia	cyaA	GO:0003674,GO:0003824,GO:0004016,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006171,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009975,GO:0009987,GO:0016829,GO:0016849,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046058,GO:0046390,GO:0046483,GO:0052652,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.6.1.1	ko:K05851	ko00230,ko02026,ko05111,map00230,map02026,map05111		R00089,R00434	RC00295	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_2672,iECOK1_1307.ECOK1_4253,iECS88_1305.ECS88_4229,iUMN146_1321.UM146_19155,iUTI89_1310.UTI89_C4365	Bacteria	1PI5T@1224,1RMPZ@1236,3XMBV@561,COG3072@1,COG3072@2	NA|NA|NA	F	Belongs to the adenylyl cyclase class-1 family
C1_03818	481805.EcolC_4202	4.2e-175	620.5	Escherichia	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018065,GO:0018130,GO:0018160,GO:0018193,GO:0018198,GO:0019438,GO:0019538,GO:0033013,GO:0033014,GO:0034641,GO:0036211,GO:0042168,GO:0042440,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.107,2.5.1.61,4.2.1.75	ko:K01749,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084,R03165,R03194	RC00003,RC00871,RC01861,RC02317	ko00000,ko00001,ko00002,ko01000			iEC55989_1330.EC55989_4275,iECH74115_1262.ECH74115_5243,iECIAI1_1343.ECIAI1_3991,iECO103_1326.ECO103_4362,iECO111_1330.ECO111_4628,iECO26_1355.ECO26_4784,iECSE_1348.ECSE_4086,iEKO11_1354.EKO11_4554,iHN637.CLJU_RS15760,iPC815.YPO3849	Bacteria	1MU56@1224,1RMQ8@1236,3XMHW@561,COG0181@1,COG0181@2	NA|NA|NA	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps
C1_03819	198214.SF3876	2.7e-137	494.6	Gammaproteobacteria	hemD	GO:0003674,GO:0003824,GO:0004852,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.107,2.5.1.61,4.2.1.75	ko:K01719,ko:K01749,ko:K02496,ko:K13542,ko:K13543	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084,R03165,R03194	RC00003,RC00871,RC01861,RC02317	ko00000,ko00001,ko00002,ko01000			iJN746.PP_0187,iSBO_1134.SBO_3815	Bacteria	1MWZD@1224,1RM9K@1236,COG1587@1,COG1587@2	NA|NA|NA	H	Uroporphyrinogen-III synthase
C1_03820	481805.EcolC_4204	8.6e-181	639.8	Escherichia	hemX		2.1.1.107,4.2.1.75	ko:K02496,ko:K06313,ko:K13543	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000			iAF1260.b3803,iBWG_1329.BWG_3482,iECDH1ME8569_1439.ECDH1ME8569_3682,iECUMN_1333.ECUMN_4327,iECs_1301.ECs4733,iEcDH1_1363.EcDH1_4176,iJO1366.b3803,iJR904.b3803,iUMN146_1321.UM146_19140,iY75_1357.Y75_RS18060,iZ_1308.Z5317	Bacteria	1MY3A@1224,1RNJY@1236,3XMMF@561,COG2959@1,COG2959@2	NA|NA|NA	H	HemX, putative uroporphyrinogen-III C-methyltransferase
C1_03821	155864.EDL933_5120	2.9e-221	774.2	Escherichia	hemY	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02498					ko00000				Bacteria	1MU7A@1224,1RMRG@1236,3XN16@561,COG3071@1,COG3071@2	NA|NA|NA	H	Involved in a late step of protoheme IX synthesis
C1_03822	155864.EDL933_5118	5.6e-16	89.4	Escherichia	aslA		3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600		R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000				Bacteria	1MUJH@1224,1RN2V@1236,3XPCB@561,COG3119@1,COG3119@2	NA|NA|NA	P	arylsulfatase activity
C1_03823	155864.EDL933_5117	7e-247	859.4	Escherichia	aslB	GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0019538,GO:0043170,GO:0044238,GO:0051604,GO:0071704,GO:1901564		ko:K06871					ko00000				Bacteria	1MX3M@1224,1RN4R@1236,3XPDR@561,COG0641@1,COG0641@2	NA|NA|NA	C	protein maturation
C1_03828	155864.EDL933_5116	1.2e-255	888.6	Escherichia	yifK	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03293					ko00000	2.A.3.1			Bacteria	1MUPS@1224,1RR4H@1236,3XNRA@561,COG1113@1,COG1113@2	NA|NA|NA	E	transport protein
C1_03829	481805.EcolC_4208	2.4e-138	498.0	Escherichia	rffM	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009246,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0046378,GO:0071704,GO:1901135,GO:1901137,GO:1901576	2.4.1.180,2.4.1.187	ko:K02852,ko:K05946	ko05111,map05111				ko00000,ko00001,ko01000,ko01003		GT26	iLF82_1304.LF82_1862	Bacteria	1N1HD@1224,1RP6P@1236,3XMEI@561,COG1922@1,COG1922@2	NA|NA|NA	M	Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis
C1_03830	155864.EDL933_5114	1.5e-250	871.7	Escherichia	wzyE	GO:0000271,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009246,GO:0009987,GO:0016020,GO:0016051,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046378,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576		ko:K02853					ko00000,ko01000,ko01003				Bacteria	1MVRX@1224,1RR2C@1236,2DB7H@1,2Z7MA@2,3XPD5@561	NA|NA|NA	S	Probably involved in the polymerization of enterobacterial common antigen (ECA) trisaccharide repeat units
C1_03831	481805.EcolC_4210	1.4e-206	725.3	Escherichia	rffT		2.4.1.325	ko:K11055,ko:K12582			R10303	RC00005,RC00049	ko00000,ko01000,ko01003		GT56	iSFV_1184.SFV_3711,iSF_1195.SF3867,iSFxv_1172.SFxv_4213,iS_1188.S3893	Bacteria	1QV3U@1224,1T279@1236,3XRNC@561,COG1819@1,COG1819@2	NA|NA|NA	CG	Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis
C1_03832	362663.ECP_3983	4.6e-222	776.9	Escherichia	wzxE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03328,ko:K16693					ko00000,ko02000	2.A.66.2,2.A.66.2.3		iSDY_1059.SDY_3956	Bacteria	1MV5E@1224,1RP0A@1236,3XMWN@561,COG2244@1,COG2244@2	NA|NA|NA	U	Mediates the transbilayer movement of Und-PP-GlcNAc- ManNAcA-Fuc4NAc (lipid III) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of enterobacterial common antigen (ECA)
C1_03833	362663.ECP_3982	8.4e-207	726.1	Escherichia	wecE	GO:0000271,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005975,GO:0005976,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009246,GO:0009987,GO:0016051,GO:0016740,GO:0016769,GO:0019180,GO:0019842,GO:0030170,GO:0033692,GO:0034637,GO:0034645,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0046378,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901135,GO:1901137,GO:1901363,GO:1901576	2.6.1.59	ko:K02805					ko00000,ko01000,ko01007			iE2348C_1286.E2348C_4092,iEC55989_1330.EC55989_4263,iECIAI1_1343.ECIAI1_3978,iECIAI39_1322.ECIAI39_2996,iECO103_1326.ECO103_4373,iECO111_1330.ECO111_4617,iECO26_1355.ECO26_4795,iECUMN_1333.ECUMN_4316,iECW_1372.ECW_m4089,iEKO11_1354.EKO11_4565,iSSON_1240.SSON_3963,iWFL_1372.ECW_m4089	Bacteria	1MUPN@1224,1RNEQ@1236,3XMFI@561,COG0399@1,COG0399@2	NA|NA|NA	E	Catalyzes the synthesis of dTDP-4-amino-4,6-dideoxy-D- galactose (dTDP-Fuc4N) from dTDP-4-keto-6-deoxy-D-glucose (dTDP-D- Glc4O) and L-glutamate
C1_03834	199310.c4710	3.6e-120	437.6	Escherichia	wecD	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0008080,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009246,GO:0009987,GO:0016051,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044464,GO:0046378,GO:0071704,GO:1901135,GO:1901137,GO:1901576	2.3.1.210	ko:K03826,ko:K16704					ko00000,ko01000			iAF1260.b3790,iBWG_1329.BWG_3472,iECBD_1354.ECBD_4249,iECDH10B_1368.ECDH10B_3979,iECDH1ME8569_1439.ECDH1ME8569_3672,iECIAI39_1322.ECIAI39_2997,iECNA114_1301.ECNA114_3928,iEcDH1_1363.EcDH1_4186,iEcolC_1368.EcolC_4213,iJO1366.b3790,iJR904.b3790,iSFV_1184.SFV_3714,iY75_1357.Y75_RS18130	Bacteria	1PHCJ@1224,1RYNF@1236,3XNBF@561,COG0454@1,COG0456@2	NA|NA|NA	K	Catalyzes the acetylation of dTDP-fucosamine (dTDP-4- amino-4,6-dideoxy-D-galactose) to dTDP-Fuc4NAc, which is utilized in the biosynthesis of the enterobacterial common antigen (ECA)
C1_03835	198214.SF3863	1.8e-167	595.1	Gammaproteobacteria	rfbA	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005976,GO:0005996,GO:0006006,GO:0006139,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008879,GO:0009058,GO:0009059,GO:0009117,GO:0009141,GO:0009147,GO:0009200,GO:0009211,GO:0009219,GO:0009225,GO:0009226,GO:0009262,GO:0009394,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019299,GO:0019300,GO:0019305,GO:0019318,GO:0019319,GO:0019438,GO:0019637,GO:0019692,GO:0030312,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045226,GO:0046075,GO:0046364,GO:0046379,GO:0046383,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000			iNJ661.Rv0334,iSF_1195.SF2102,iSFxv_1172.SFxv_2338,iS_1188.S2225,iUMNK88_1353.UMNK88_4598,iYL1228.KPN_04289	Bacteria	1MU0X@1224,1RMTR@1236,COG1209@1,COG1209@2	NA|NA|NA	H	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C1_03836	481805.EcolC_4215	2.2e-209	734.6	Escherichia	rffG	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008460,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016829,GO:0016835,GO:0016836,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0045226,GO:0046379,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000			iECNA114_1301.ECNA114_3926,iECO26_1355.ECO26_2952,iECSF_1327.ECSF_3628	Bacteria	1MU5E@1224,1RP7G@1236,3XM8Z@561,COG1088@1,COG1088@2	NA|NA|NA	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
C1_03837	155864.EDL933_5107	1.5e-241	841.6	Escherichia	wecC	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009246,GO:0009987,GO:0016051,GO:0016491,GO:0016614,GO:0016616,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046378,GO:0055114,GO:0071704,GO:0089714,GO:1901135,GO:1901137,GO:1901576	1.1.1.336	ko:K02472,ko:K02474	ko00520,ko05111,map00520,map05111		R03317,R06894	RC00291	ko00000,ko00001,ko01000,ko01005			iECSE_1348.ECSE_4070	Bacteria	1MUC6@1224,1RMX0@1236,3XNEF@561,COG0677@1,COG0677@2	NA|NA|NA	M	Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD( ) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA)
C1_03838	155864.EDL933_5106	2.4e-217	761.1	Escherichia	wecB	GO:0000271,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0008761,GO:0009058,GO:0009059,GO:0009246,GO:0009987,GO:0016051,GO:0016853,GO:0016854,GO:0016857,GO:0033692,GO:0034637,GO:0034645,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046378,GO:0071704,GO:1901135,GO:1901137,GO:1901576	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005			iECOK1_1307.ECOK1_4232,iECS88_1305.ECS88_4208,iECs_1301.ECs4719,iEcSMS35_1347.EcSMS35_4150,iG2583_1286.G2583_4580,iPC815.YPO3864,iSDY_1059.SDY_3962,iSSON_1240.SSON_3958,iUMN146_1321.UM146_19070,iZ_1308.Z5297	Bacteria	1MWZN@1224,1RPNC@1236,3XM4Q@561,COG0381@1,COG0381@2	NA|NA|NA	M	Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues
C1_03839	155864.EDL933_5105	1.2e-196	692.2	Escherichia	wzzE	GO:0000271,GO:0003674,GO:0005488,GO:0005515,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009246,GO:0009987,GO:0016051,GO:0033692,GO:0034637,GO:0034645,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0046378,GO:0071704,GO:1901135,GO:1901137,GO:1901576		ko:K05789,ko:K05790					ko00000,ko01005			iAF1260.b3785,iB21_1397.B21_03612,iBWG_1329.BWG_3467,iECBD_1354.ECBD_4254,iECB_1328.ECB_03663,iECDH10B_1368.ECDH10B_3974,iECDH1ME8569_1439.ECDH1ME8569_3667,iECD_1391.ECD_03663,iECH74115_1262.ECH74115_5218,iECIAI1_1343.ECIAI1_3972,iECSP_1301.ECSP_4833,iECUMN_1333.ECUMN_4310,iETEC_1333.ETEC_4067,iEcDH1_1363.EcDH1_4191,iEcE24377_1341.EcE24377A_4296,iEcHS_1320.EcHS_A4002,iJO1366.b3785,iSF_1195.SF3859,iS_1188.S3901,iSbBS512_1146.SbBS512_E4136,iUMNK88_1353.UMNK88_4594,iY75_1357.Y75_RS18155	Bacteria	1MW70@1224,1RRBS@1236,3XNGX@561,COG3765@1,COG3765@2	NA|NA|NA	M	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
C1_03840	198214.SF3858	2.1e-202	711.4	Gammaproteobacteria	wecA	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0005975,GO:0005976,GO:0006629,GO:0008144,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008963,GO:0009058,GO:0009059,GO:0009103,GO:0009246,GO:0009274,GO:0009276,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016051,GO:0016740,GO:0016772,GO:0016780,GO:0030145,GO:0030312,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0033692,GO:0034637,GO:0034645,GO:0042546,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046378,GO:0046872,GO:0046914,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.7.8.33,2.7.8.35,5.1.3.14	ko:K01791,ko:K02851	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420,R08856	RC00002,RC00290	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005			iAF987.Gmet_1505,iECSF_1327.ECSF_3624	Bacteria	1MWYW@1224,1RNAP@1236,COG0472@1,COG0472@2	NA|NA|NA	M	Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP- C55)
C1_03841	155864.EDL933_5103	6.7e-36	156.0	Gammaproteobacteria													Bacteria	1NYNU@1224,1SQJM@1236,2CHHE@1,33ZHN@2	NA|NA|NA		
C1_03842	1440052.EAKF1_ch2156c	5.3e-234	816.6	Escherichia	rho	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576		ko:K02887,ko:K03628	ko03010,ko03018,map03010,map03018	M00178			br01610,ko00000,ko00001,ko00002,ko03011,ko03019,ko03021				Bacteria	1MUCF@1224,1RP95@1236,3XPGE@561,COG1158@1,COG1158@2	NA|NA|NA	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C1_03843	1080067.BAZH01000037_gene1962	1.8e-56	224.9	Citrobacter	trxA	GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748		ko:K03671	ko04621,ko05418,map04621,map05418				ko00000,ko00001,ko03110			iECW_1372.ECW_m4079,iECs_1301.ECs4714,iEKO11_1354.EKO11_4576,iG2583_1286.G2583_4574,iSBO_1134.SBO_3791,iSDY_1059.SDY_3968,iSF_1195.SF3854,iSSON_1240.SSON_3952,iS_1188.S3905,iWFL_1372.ECW_m4079,iZ_1308.Z5291	Bacteria	1MZBB@1224,1S5WR@1236,3WYGA@544,COG3118@1,COG3118@2	NA|NA|NA	O	Thioredoxin
C1_03844	198214.SF3853	9e-242	842.4	Gammaproteobacteria	rhlB	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0019904,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0090304,GO:0097718,GO:0140098,GO:1901360,GO:1901361,GO:1901575	3.6.4.13	ko:K03732	ko03018,map03018	M00394			ko00000,ko00001,ko00002,ko01000,ko03019				Bacteria	1MU49@1224,1RMWA@1236,COG0513@1,COG0513@2	NA|NA|NA	JKL	DEAD-box RNA helicase involved in
C1_03845	155864.EDL933_5099	2.4e-278	964.1	Escherichia	gppA	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006793,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008894,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034641,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:1901360	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230		R03409	RC00002	ko00000,ko00001,ko01000			iECABU_c1320.ECABU_c42590,iECED1_1282.ECED1_4463,iECIAI39_1322.ECIAI39_2643	Bacteria	1MV35@1224,1RN3V@1236,3XMDD@561,COG0248@1,COG0248@2	NA|NA|NA	F	Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the stringent response , an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities
C1_03846	155864.EDL933_5098	0.0	1329.3	Escherichia	rep	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022402,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044786,GO:0044787,GO:0046483,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	3.6.4.12	ko:K03656,ko:K03657	ko03420,ko03430,map03420,map03430				ko00000,ko00001,ko01000,ko03400				Bacteria	1MU0G@1224,1RNJI@1236,3XMV2@561,COG0210@1,COG0210@2	NA|NA|NA	L	it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction
C1_03847	155864.EDL933_5097	8e-76	289.7	Gammaproteobacteria													Bacteria	1RJX6@1224,1S7HT@1236,COG3692@1,COG3692@2	NA|NA|NA	S	PemK-like, MazF-like toxin of type II toxin-antitoxin system
C1_03848	1218086.BBNB01000018_gene1192	4.9e-47	193.4	Citrobacter	ppiC	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0071704,GO:0140096,GO:1901564	5.2.1.8	ko:K03769					ko00000,ko01000,ko03110				Bacteria	1MZDK@1224,1S9DN@1236,3WYKX@544,COG0760@1,COG0760@2	NA|NA|NA	O	PPIC-type PPIASE domain
C1_03849	199310.c4696	2.3e-281	974.2	Escherichia	ilvC	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004455,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0022607,GO:0036094,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050661,GO:0050662,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000			iEC042_1314.EC042_4152,iECABU_c1320.ECABU_c42560,iECED1_1282.ECED1_4460,iECO103_1326.ECO103_4390,iECO111_1330.ECO111_4600,iECO26_1355.ECO26_4812,iECP_1309.ECP_3967,iECSE_1348.ECSE_4057,iECUMN_1333.ECUMN_4300,iEcE24377_1341.EcE24377A_4285,iEcSMS35_1347.EcSMS35_4140,iIT341.HP0330,iLF82_1304.LF82_1103	Bacteria	1MV7M@1224,1RNA8@1236,3XMWQ@561,COG0059@1,COG0059@2	NA|NA|NA	EH	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C1_03850	155864.EDL933_5094	1.7e-165	588.6	Escherichia	ilvY	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464		ko:K02521					ko00000,ko03000				Bacteria	1MZX1@1224,1RNFR@1236,3XMHE@561,COG0583@1,COG0583@2	NA|NA|NA	K	transcriptional regulator IlvY
C1_03851	155864.EDL933_5093	1e-295	1021.9	Escherichia	ilvA	GO:0003674,GO:0003824,GO:0004794,GO:0005488,GO:0006082,GO:0006520,GO:0006549,GO:0006566,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009081,GO:0009082,GO:0009097,GO:0009987,GO:0016053,GO:0016597,GO:0016829,GO:0016840,GO:0016841,GO:0019752,GO:0019842,GO:0030170,GO:0031406,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.1.15,4.3.1.19	ko:K01751,ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_2699,iECED1_1282.ECED1_3331	Bacteria	1MVWJ@1224,1RMY6@1236,3XN65@561,COG1171@1,COG1171@2	NA|NA|NA	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C1_03852	469008.B21_03598	0.0	1204.9	Escherichia	ilvD	GO:0003674,GO:0003824,GO:0004160,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000			iAF987.Gmet_1259,iECIAI39_1322.ECIAI39_3015	Bacteria	1MUTQ@1224,1RMP2@1236,3XNTA@561,COG0129@1,COG0129@2	NA|NA|NA	E	Dihydroxy-acid dehydratase
C1_03853	155864.EDL933_5091	5.7e-177	626.7	Escherichia	ilvE	GO:0003674,GO:0003824,GO:0004084,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006531,GO:0006532,GO:0006551,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009081,GO:0009082,GO:0009098,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.21,2.6.1.42	ko:K00824,ko:K00826	ko00270,ko00280,ko00290,ko00310,ko00330,ko00360,ko00472,ko00473,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00310,map00330,map00360,map00472,map00473,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01148,R01214,R01582,R02199,R02459,R02851,R02924,R05053,R10991	RC00006,RC00008,RC00025,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007			iB21_1397.B21_03597,iECBD_1354.ECBD_4269,iECB_1328.ECB_03648,iECD_1391.ECD_03648,iECO103_1326.ECO103_4394	Bacteria	1MVB0@1224,1RP6Z@1236,3XMH2@561,COG0115@1,COG0115@2	NA|NA|NA	E	Acts on leucine, isoleucine and valine
C1_03854	1440052.EAKF1_ch2172c	1.1e-40	172.2	Escherichia	ilvM	GO:0003674,GO:0003824,GO:0003984,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576	2.2.1.6	ko:K01653,ko:K11258	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000				Bacteria	1MZ9W@1224,1S8VQ@1236,3XPY7@561,COG3978@1,COG3978@2	NA|NA|NA	E	acetolactate synthase activity
C1_03855	155864.EDL933_5089	0.0	1100.9	Escherichia	ilvG		2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000				Bacteria	1MU6U@1224,1RMQQ@1236,3XMNP@561,COG0028@1,COG0028@2	NA|NA|NA	H	Thiamine pyrophosphate enzyme, central domain
C1_03856	34506.g1348	1e-284	985.3	Bilateria													Metazoa	2E0SH@1,2S868@2759,3A9FW@33154,3BUAQ@33208,3DD4V@33213	NA|NA|NA	O	Magnesium chelatase, subunit ChlI C-terminal
C1_03857	155864.EDL933_5087	5e-54	216.9	Escherichia	yifE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0007059,GO:0008150,GO:0009987,GO:0016043,GO:0044424,GO:0044444,GO:0044464,GO:0051276,GO:0071840		ko:K09897					ko00000				Bacteria	1RD72@1224,1S3NW@1236,3XPT4@561,COG3085@1,COG3085@2	NA|NA|NA	S	Belongs to the UPF0438 family
C1_03858	198214.SF3839	1.5e-155	555.4	Gammaproteobacteria	hdfR	GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141											Bacteria	1MXXA@1224,1RREE@1236,COG0583@1,COG0583@2	NA|NA|NA	K	Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon
C1_03865	155864.EDL933_5085	3.4e-126	457.6	Escherichia	yieP	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K19776					ko00000,ko03000				Bacteria	1MV83@1224,1RR9F@1236,3XM43@561,COG2186@1,COG2186@2	NA|NA|NA	K	DNA-binding transcription factor activity
C1_03866	316407.85676284	9.8e-253	879.0	Escherichia	hsrA	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944											Bacteria	1QTWJ@1224,1T1QY@1236,3XNAU@561,COG0477@1,COG0477@2	NA|NA|NA	EGP	Major facilitator superfamily
C1_03867	199310.c4681	2.1e-185	654.8	Escherichia	rbsR	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141		ko:K02529,ko:K03604					ko00000,ko03000				Bacteria	1MVUR@1224,1RN2K@1236,3XNVG@561,COG1609@1,COG1609@2	NA|NA|NA	K	Transcriptional repressor for the ribose rbsDACBK operon. RbsR binds to a region of perfect dyad symmetry spanning the rbs operon transcriptional start site. The affinity for the rbs operator is reduced by addition of ribose, consistent with ribose being the inducer of the operon
C1_03868	155864.EDL933_5082	4.3e-164	583.9	Escherichia	rbsK	GO:0003674,GO:0003824,GO:0004747,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019303,GO:0019321,GO:0019323,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046835,GO:0071704,GO:1901575	2.7.1.15	ko:K00852	ko00030,map00030		R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000			iE2348C_1286.E2348C_4062,iEcDH1_1363.EcDH1_4215	Bacteria	1MV5B@1224,1RNVY@1236,3XNNI@561,COG0524@1,COG0524@2	NA|NA|NA	F	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1_03869	155864.EDL933_5081	1.3e-154	552.4	Escherichia	rbsB	GO:0003674,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006935,GO:0008150,GO:0008643,GO:0009605,GO:0015144,GO:0015145,GO:0015749,GO:0015750,GO:0015752,GO:0016020,GO:0016021,GO:0022857,GO:0030246,GO:0030288,GO:0030313,GO:0031224,GO:0031975,GO:0034219,GO:0036094,GO:0040011,GO:0042221,GO:0042330,GO:0042597,GO:0044425,GO:0044464,GO:0048029,GO:0050896,GO:0050918,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944		ko:K02058,ko:K10439	ko02010,ko02030,map02010,map02030	M00212,M00221			ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19			Bacteria	1NRXG@1224,1RPBV@1236,3XMWE@561,COG1879@1,COG1879@2	NA|NA|NA	G	Part of the ABC transporter complex RbsABC involved in ribose import. Binds ribose. Also serves as the primary chemoreceptor for chemotaxis
C1_03870	155864.EDL933_5080	9.2e-162	576.2	Escherichia	rbsC	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015146,GO:0015591,GO:0015749,GO:0015750,GO:0015752,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0032991,GO:0034219,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351		ko:K03549,ko:K10440	ko02010,map02010	M00212			ko00000,ko00001,ko00002,ko02000	2.A.72,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19		iAF1260.b3750,iAPECO1_1312.APECO1_2713,iB21_1397.B21_03581,iBWG_1329.BWG_3441,iE2348C_1286.E2348C_4060,iEC042_1314.EC042_4137,iEC55989_1330.EC55989_4225,iECABU_c1320.ECABU_c42350,iECBD_1354.ECBD_4280,iECB_1328.ECB_03636,iECDH10B_1368.ECDH10B_3938,iECDH1ME8569_1439.ECDH1ME8569_3638,iECED1_1282.ECED1_4440,iECH74115_1262.ECH74115_5186,iECIAI1_1343.ECIAI1_3934,iECNA114_1301.ECNA114_3899,iECO103_1326.ECO103_4407,iECO111_1330.ECO111_4584,iECO26_1355.ECO26_4828,iECOK1_1307.ECOK1_4199,iECS88_1305.ECS88_4172,iECSE_1348.ECSE_4040,iECSF_1327.ECSF_3598,iECSP_1301.ECSP_4800,iECUMN_1333.ECUMN_4280,iECs_1301.ECs4692,iEcDH1_1363.EcDH1_4217,iEcE24377_1341.EcE24377A_4266,iEcHS_1320.EcHS_A3966,iEcSMS35_1347.EcSMS35_4118,iEcolC_1368.EcolC_4244,iJO1366.b3750,iJR904.b3750,iLF82_1304.LF82_1817,iNRG857_1313.NRG857_18675,iUMN146_1321.UM146_18940,iUMNK88_1353.UMNK88_4562,iUTI89_1310.UTI89_C4305,iY75_1357.Y75_RS18320,ic_1306.c4678	Bacteria	1MX7D@1224,1RNTS@1236,3XN9E@561,COG1172@1,COG1172@2	NA|NA|NA	G	Part of the ABC transporter complex RbsABC involved in ribose import. Probably responsible for the translocation of the substrate across the membrane
C1_03871	469008.B21_03580	5.3e-281	973.0	Escherichia	rbsA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008144,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015146,GO:0015399,GO:0015405,GO:0015407,GO:0015591,GO:0015608,GO:0015611,GO:0015749,GO:0015750,GO:0015752,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0031224,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034219,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043190,GO:0043211,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0097159,GO:0097367,GO:0098533,GO:0098796,GO:0098797,GO:1901265,GO:1901363,GO:1902494,GO:1902495,GO:1904949,GO:1990351	3.6.3.17	ko:K10441,ko:K10542	ko02010,map02010	M00212,M00214			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.3		iEC55989_1330.EC55989_4224,iECSE_1348.ECSE_4039,iECW_1372.ECW_m4052,iEcE24377_1341.EcE24377A_4265,iWFL_1372.ECW_m4052,iYL1228.KPN_04154	Bacteria	1MU22@1224,1RMCH@1236,3XN9K@561,COG1129@1,COG1129@2	NA|NA|NA	P	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system
C1_03872	198214.SF3829	4.7e-70	270.4	Gammaproteobacteria	rbsD	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0009056,GO:0015144,GO:0015145,GO:0015146,GO:0015399,GO:0015405,GO:0015407,GO:0015591,GO:0015608,GO:0015611,GO:0015749,GO:0015750,GO:0015752,GO:0016052,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016866,GO:0016887,GO:0017111,GO:0019303,GO:0019321,GO:0019323,GO:0022804,GO:0022857,GO:0034219,GO:0042623,GO:0042626,GO:0042802,GO:0043211,GO:0043492,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704,GO:1901575	5.4.99.62	ko:K06726	ko02010,map02010		R08247	RC02247	ko00000,ko00001,ko01000			iAF1260.b3748,iBWG_1329.BWG_3439,iECDH10B_1368.ECDH10B_3936,iECDH1ME8569_1439.ECDH1ME8569_3636,iECH74115_1262.ECH74115_5184,iECSP_1301.ECSP_4798,iECs_1301.ECs4690,iETEC_1333.ETEC_4039,iEcDH1_1363.EcDH1_4219,iJO1366.b3748,iJR904.b3748,iY75_1357.Y75_RS18330	Bacteria	1RI53@1224,1S60T@1236,COG1869@1,COG1869@2	NA|NA|NA	G	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose
C1_03873	199310.c4675	0.0	1211.4	Escherichia	kup	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098660,GO:0098662		ko:K03549					ko00000,ko02000	2.A.72		iECs_1301.ECs4689,iG2583_1286.G2583_4543,iZ_1308.Z5248	Bacteria	1MUVH@1224,1RPM6@1236,3XMNU@561,COG3158@1,COG3158@2	NA|NA|NA	P	Responsible for the low-affinity transport of potassium into the cell, with the
C1_03874	316407.85676292	2.2e-279	967.6	Escherichia	ravA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0042802,GO:0044424,GO:0044444,GO:0044464		ko:K03924					ko00000,ko01000				Bacteria	1PC08@1224,1RQ5U@1236,3XMMQ@561,COG0714@1,COG0714@2	NA|NA|NA	S	Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone
C1_03875	155864.EDL933_5075	3.7e-271	940.3	Escherichia	viaA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0016020,GO:0032781,GO:0043085,GO:0043462,GO:0044093,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0051336,GO:0051345,GO:0065007,GO:0065009											Bacteria	1N1RQ@1224,1RPQT@1236,3XNVH@561,COG2425@1,COG2425@2	NA|NA|NA	S	VWA domain protein interacting with AAA ATPase
C1_03876	155864.EDL933_5074	4.8e-190	670.2	Escherichia	asnA	GO:0003674,GO:0003824,GO:0004071,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006528,GO:0006529,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009987,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019752,GO:0032787,GO:0033554,GO:0034641,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.1.1	ko:K01914	ko00250,ko00460,ko01100,ko01110,ko01230,map00250,map00460,map01100,map01110,map01230		R00483	RC00010	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_2719,iECOK1_1307.ECOK1_4193,iECS88_1305.ECS88_4166,iUMN146_1321.UM146_18910,iUTI89_1310.UTI89_C4299	Bacteria	1MVWF@1224,1RN79@1236,3XNFG@561,COG2502@1,COG2502@2	NA|NA|NA	F	aspartate--ammonia ligase
C1_03877	155864.EDL933_5073	2.5e-77	294.7	Escherichia	asnC	GO:0001101,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016597,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031406,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043177,GO:0043200,GO:0043565,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1901698,GO:1901700,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141		ko:K03718					ko00000,ko03000				Bacteria	1MWPX@1224,1RRPA@1236,3XM6Y@561,COG1522@1,COG1522@2	NA|NA|NA	K	and repressor of the expression of gidA at a post-transcriptional level
C1_03878	469008.B21_03570	7.6e-79	299.7	Escherichia	mioC	GO:0000166,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0010181,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0050789,GO:0050794,GO:0051302,GO:0065007,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K06205					ko00000				Bacteria	1N30T@1224,1S403@1236,3XP8U@561,COG0716@1,COG0716@2	NA|NA|NA	C	electron transporter required for biotin synthase activity
C1_03879	199310.c4669	0.0	1234.6	Escherichia	gidA	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363		ko:K03495			R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036				Bacteria	1MU6F@1224,1RMM1@1236,3XNZB@561,COG0445@1,COG0445@2	NA|NA|NA	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
C1_03880	155864.EDL933_5070	2.7e-114	417.9	Escherichia	rsmG	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.170	ko:K03501					ko00000,ko01000,ko03009,ko03036				Bacteria	1MY0K@1224,1RMRZ@1236,3XMZH@561,COG0357@1,COG0357@2	NA|NA|NA	J	Specifically methylates the N7 position of guanine in position 527 of 16S rRNA
C1_03881	198214.SF3819	6e-56	223.4	Gammaproteobacteria	atpI	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0044769,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600		ko:K02116					ko00000,ko00194	3.A.2.1		iSSON_1240.SSON_3880	Bacteria	1RITN@1224,1S767@1236,COG3312@1,COG3312@2	NA|NA|NA	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation
C1_03882	155864.EDL933_5068	1.6e-146	525.4	Escherichia	atpB	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600		ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157			ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1		iAPECO1_1312.APECO1_2725,iE2348C_1286.E2348C_4048,iEC042_1314.EC042_4125,iECABU_c1320.ECABU_c42230,iECED1_1282.ECED1_4428,iECIAI39_1322.ECIAI39_4342,iECNA114_1301.ECNA114_3887,iECOK1_1307.ECOK1_4187,iECP_1309.ECP_3937,iECS88_1305.ECS88_4160,iECSF_1327.ECSF_3586,iECUMN_1333.ECUMN_4268,iEcSMS35_1347.EcSMS35_4106,iLF82_1304.LF82_0192,iNRG857_1313.NRG857_18615,iUMN146_1321.UM146_18880,iUMNK88_1353.UMNK88_4550,iUTI89_1310.UTI89_C4293,ic_1306.c4666	Bacteria	1MV87@1224,1RPHK@1236,3XMPD@561,COG0356@1,COG0356@2	NA|NA|NA	C	it plays a direct role in the translocation of protons across the membrane
C1_03883	1005994.GTGU_04025	2.2e-32	144.4	Gammaproteobacteria	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600		ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157			ko00000,ko00001,ko00002,ko00194	3.A.2.1			Bacteria	1N1NA@1224,1S9MD@1236,32S3K@2,COG0636@1	NA|NA|NA	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C1_03884	155864.EDL933_5066	9.3e-59	233.0	Escherichia	atpF	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031225,GO:0032991,GO:0033177,GO:0034220,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1902600		ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157			ko00000,ko00001,ko00002,ko00194	3.A.2.1		e_coli_core.b3736,iAF1260.b3736,iB21_1397.B21_03564,iBWG_1329.BWG_3427,iE2348C_1286.E2348C_4046,iEC042_1314.EC042_4123,iEC55989_1330.EC55989_4211,iECABU_c1320.ECABU_c42210,iECBD_1354.ECBD_4296,iECB_1328.ECB_03620,iECDH10B_1368.ECDH10B_3923,iECDH1ME8569_1439.ECDH1ME8569_3624,iECD_1391.ECD_03620,iECED1_1282.ECED1_4426,iECH74115_1262.ECH74115_5172,iECIAI1_1343.ECIAI1_3920,iECIAI39_1322.ECIAI39_4340,iECO103_1326.ECO103_4422,iECO111_1330.ECO111_4570,iECO26_1355.ECO26_4842,iECOK1_1307.ECOK1_4185,iECP_1309.ECP_3935,iECS88_1305.ECS88_4158,iECSE_1348.ECSE_4026,iECSF_1327.ECSF_3584,iECSP_1301.ECSP_4786,iECUMN_1333.ECUMN_4266,iECW_1372.ECW_m4039,iECs_1301.ECs4678,iEKO11_1354.EKO11_4609,iETEC_1333.ETEC_4027,iEcDH1_1363.EcDH1_4231,iEcE24377_1341.EcE24377A_4252,iEcHS_1320.EcHS_A3952,iEcSMS35_1347.EcSMS35_4104,iEcolC_1368.EcolC_4258,iG2583_1286.G2583_4532,iJO1366.b3736,iJR904.b3736,iSDY_1059.SDY_4012,iSFV_1184.SFV_3762,iSF_1195.SF3816,iSFxv_1172.SFxv_4159,iSSON_1240.SSON_3883,iS_1188.S3952,iSbBS512_1146.SbBS512_E4185,iUMN146_1321.UM146_18870,iUMNK88_1353.UMNK88_4548,iUTI89_1310.UTI89_C4291,iWFL_1372.ECW_m4039,iY75_1357.Y75_RS18390,iZ_1308.Z5234,ic_1306.c4664	Bacteria	1RHZ0@1224,1S402@1236,3XNMY@561,COG0711@1,COG0711@2	NA|NA|NA	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C1_03885	155864.EDL933_5065	2.8e-88	331.3	Escherichia	atpH	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600		ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157			ko00000,ko00001,ko00002,ko00194	3.A.2.1		iSF_1195.SF3815,iSFxv_1172.SFxv_4157,iS_1188.S3953	Bacteria	1MVRH@1224,1S8X2@1236,3XMJ4@561,COG0712@1,COG0712@2	NA|NA|NA	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C1_03886	1440052.EAKF1_ch2199	1.2e-285	988.4	Escherichia	atpA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157			ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1		iIT341.HP1134,iSB619.SA_RS10975,iSbBS512_1146.SbBS512_E4187	Bacteria	1MUG7@1224,1RP4V@1236,3XP3D@561,COG0056@1,COG0056@2	NA|NA|NA	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C1_03887	155864.EDL933_5063	2e-155	555.1	Escherichia	atpG	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600		ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157			ko00000,ko00001,ko00002,ko00194	3.A.2.1		iLJ478.TM1611,iSSON_1240.SSON_3886,iYL1228.KPN_04138	Bacteria	1MU28@1224,1RNWJ@1236,3XPI3@561,COG0224@1,COG0224@2	NA|NA|NA	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C1_03888	1440052.EAKF1_ch2201	7.5e-258	896.0	Escherichia	atpD	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157			ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1		e_coli_core.b3732,iAF1260.b3732,iAPECO1_1312.APECO1_2729,iB21_1397.B21_03560,iBWG_1329.BWG_3423,iE2348C_1286.E2348C_4042,iEC042_1314.EC042_4119,iEC55989_1330.EC55989_4207,iECABU_c1320.ECABU_c42160,iECBD_1354.ECBD_4300,iECB_1328.ECB_03616,iECDH10B_1368.ECDH10B_3919,iECDH1ME8569_1439.ECDH1ME8569_3620,iECD_1391.ECD_03616,iECED1_1282.ECED1_4422,iECH74115_1262.ECH74115_5168,iECIAI1_1343.ECIAI1_3916,iECIAI39_1322.ECIAI39_4336,iECNA114_1301.ECNA114_3881,iECO103_1326.ECO103_4426,iECO111_1330.ECO111_4566,iECO26_1355.ECO26_4846,iECOK1_1307.ECOK1_4181,iECP_1309.ECP_3931,iECS88_1305.ECS88_4154,iECSE_1348.ECSE_4022,iECSF_1327.ECSF_3580,iECSP_1301.ECSP_4782,iECUMN_1333.ECUMN_4262,iECW_1372.ECW_m4035,iECs_1301.ECs4674,iEKO11_1354.EKO11_4613,iETEC_1333.ETEC_4023,iEcDH1_1363.EcDH1_4235,iEcE24377_1341.EcE24377A_4247,iEcSMS35_1347.EcSMS35_4100,iEcolC_1368.EcolC_4262,iG2583_1286.G2583_4528,iJO1366.b3732,iJR904.b3732,iLF82_1304.LF82_0194,iNRG857_1313.NRG857_18585,iPC815.YPO4121,iSFV_1184.SFV_3758,iSF_1195.SF3812,iSFxv_1172.SFxv_4154,iSSON_1240.SSON_3887,iS_1188.S3956,iSbBS512_1146.SbBS512_E4189,iUMN146_1321.UM146_18850,iUMNK88_1353.UMNK88_4544,iUTI89_1310.UTI89_C4285,iWFL_1372.ECW_m4035,iY75_1357.Y75_RS18410,iZ_1308.Z5230,ic_1306.c4658	Bacteria	1MUFU@1224,1RN6U@1236,3XPEM@561,COG0055@1,COG0055@2	NA|NA|NA	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C1_03889	199310.c4657	1.4e-69	268.9	Escherichia	atpC	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600		ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157			ko00000,ko00001,ko00002,ko00194	3.A.2.1		iHN637.CLJU_RS01195,iJN746.PP_5412,iSbBS512_1146.SbBS512_E4190	Bacteria	1RHE4@1224,1S25H@1236,3XM4A@561,COG0355@1,COG0355@2	NA|NA|NA	C	Produces ATP from ADP in the presence of a proton gradient across the membrane
C1_03890	155864.EDL933_5060	4.4e-258	896.7	Escherichia	glmU	GO:0000270,GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006022,GO:0006023,GO:0006024,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006629,GO:0006725,GO:0006793,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009225,GO:0009226,GO:0009252,GO:0009273,GO:0009987,GO:0016051,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0018130,GO:0019134,GO:0019438,GO:0030203,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0042546,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0046872,GO:0055086,GO:0070569,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1903509	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000			iECED1_1282.ECED1_4420,iYL1228.KPN_04135	Bacteria	1MUPH@1224,1RNKE@1236,3XP6N@561,COG1207@1,COG1207@2	NA|NA|NA	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C1_03891	316407.85676309	0.0	1189.5	Escherichia	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009226,GO:0009987,GO:0016740,GO:0016769,GO:0018130,GO:0019438,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0034654,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931		R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002			iE2348C_1286.E2348C_4039,iEC042_1314.EC042_4115,iECIAI39_1322.ECIAI39_4333,iECNA114_1301.ECNA114_3878,iECOK1_1307.ECOK1_4178,iECSF_1327.ECSF_3577,iECUMN_1333.ECUMN_4259,iEcSMS35_1347.EcSMS35_4097,iLF82_1304.LF82_0844,iNRG857_1313.NRG857_18570,iSFV_1184.SFV_3755,iSF_1195.SF3809,iSFxv_1172.SFxv_4151,iS_1188.S3959,iUMN146_1321.UM146_18835,iUTI89_1310.UTI89_C4281	Bacteria	1MW4K@1224,1RMVN@1236,3XMF7@561,COG0449@1,COG0449@2	NA|NA|NA	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
C1_03892	198214.SF3807	1.3e-99	369.0	Gammaproteobacteria	lpfA			ko:K07345	ko05133,map05133				ko00000,ko00001,ko02035,ko02044				Bacteria	1N294@1224,1S4MK@1236,COG3539@1,COG3539@2	NA|NA|NA	NU	Fimbrial protein
C1_03893	701347.Entcl_4426	8.4e-83	313.5	Gammaproteobacteria				ko:K07346					ko00000,ko02035,ko02044,ko03110				Bacteria	1R4J7@1224,1RRW6@1236,COG3121@1,COG3121@2	NA|NA|NA	M	chaperone
C1_03894	198214.SF3723	0.0	1667.1	Gammaproteobacteria				ko:K07347,ko:K07354	ko05133,map05133				ko00000,ko00001,ko02000,ko02035,ko02044	1.B.11.3			Bacteria	1MUHE@1224,1RMPU@1236,COG3188@1,COG3188@2	NA|NA|NA	NU	Usher protein
C1_03895	198214.SF3726	3e-121	441.8	Bacteria													Bacteria	COG3539@1,COG3539@2	NA|NA|NA	NU	cell adhesion
C1_03896	198214.SF3727	2e-194	684.9	Gammaproteobacteria	pstS	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0006974,GO:0008150,GO:0009314,GO:0009628,GO:0009987,GO:0010921,GO:0015698,GO:0019220,GO:0019222,GO:0030288,GO:0030313,GO:0031323,GO:0031975,GO:0033554,GO:0035303,GO:0042301,GO:0042597,GO:0043167,GO:0043168,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0051716,GO:0065007,GO:0065009		ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222			ko00000,ko00001,ko00002,ko02000	3.A.1.7		iECH74115_1262.ECH74115_5157,iECSP_1301.ECSP_4770,iECs_1301.ECs4664,iG2583_1286.G2583_4518,iZ_1308.Z5219	Bacteria	1MUAZ@1224,1RN5Q@1236,COG0226@1,COG0226@2	NA|NA|NA	P	Part of the ABC transporter complex PstSACB involved in phosphate import
C1_03897	155864.EDL933_5050	1.6e-169	602.1	Escherichia	pstC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0009314,GO:0009628,GO:0010921,GO:0015698,GO:0016020,GO:0016021,GO:0019220,GO:0019222,GO:0031224,GO:0031226,GO:0031323,GO:0034220,GO:0035303,GO:0035435,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0051704,GO:0055085,GO:0065007,GO:0065009,GO:0071944,GO:0098656,GO:0098660,GO:0098661		ko:K02037,ko:K02038	ko02010,map02010	M00222			ko00000,ko00001,ko00002,ko02000	3.A.1.7		ic_1306.c4652	Bacteria	1MVKP@1224,1RQXJ@1236,3XM5Y@561,COG0573@1,COG0573@2	NA|NA|NA	P	probably responsible for the translocation of the substrate across the membrane
C1_03898	155864.EDL933_5049	7e-156	556.6	Escherichia	pstA	GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0010921,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0019220,GO:0019222,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0031323,GO:0033554,GO:0034220,GO:0035303,GO:0035435,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0051704,GO:0051716,GO:0055085,GO:0065007,GO:0065009,GO:0071944,GO:0098656,GO:0098660,GO:0098661		ko:K02037,ko:K02038	ko02010,map02010	M00222			ko00000,ko00001,ko00002,ko02000	3.A.1.7		iYL1228.KPN_04131,iZ_1308.Z5217	Bacteria	1MUWB@1224,1RPV9@1236,3XM86@561,COG0581@1,COG0581@2	NA|NA|NA	P	Phosphate transport system permease protein PstA
C1_03899	155864.EDL933_5048	1.8e-144	518.5	Escherichia	pstB	GO:0000166,GO:0003674,GO:0005215,GO:0005315,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008144,GO:0008150,GO:0010921,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0017076,GO:0019220,GO:0019222,GO:0022804,GO:0022857,GO:0030554,GO:0031323,GO:0032553,GO:0032555,GO:0032559,GO:0034220,GO:0035303,GO:0035435,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0055085,GO:0065007,GO:0065009,GO:0071944,GO:0097159,GO:0097367,GO:0098656,GO:0098660,GO:0098661,GO:1901265,GO:1901363	3.6.3.27	ko:K02036	ko02010,map02010	M00222			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7			Bacteria	1MU16@1224,1RNUF@1236,3XNH7@561,COG1117@1,COG1117@2	NA|NA|NA	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
C1_03900	199310.c4648	1.1e-130	472.6	Escherichia	phoU	GO:0000287,GO:0001558,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006873,GO:0006950,GO:0007154,GO:0008150,GO:0009266,GO:0009267,GO:0009268,GO:0009405,GO:0009408,GO:0009605,GO:0009628,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010563,GO:0010605,GO:0010629,GO:0010966,GO:0016020,GO:0016036,GO:0019220,GO:0019222,GO:0019725,GO:0019897,GO:0019898,GO:0022898,GO:0030002,GO:0030145,GO:0030320,GO:0030643,GO:0031323,GO:0031324,GO:0031667,GO:0031668,GO:0031669,GO:0032409,GO:0032410,GO:0032412,GO:0032413,GO:0032879,GO:0033554,GO:0034605,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0040008,GO:0042221,GO:0042592,GO:0042594,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043269,GO:0043271,GO:0044070,GO:0044092,GO:0044419,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045936,GO:0046677,GO:0046872,GO:0046914,GO:0046983,GO:0048519,GO:0048523,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0051049,GO:0051051,GO:0051128,GO:0051174,GO:0051704,GO:0051716,GO:0055062,GO:0055081,GO:0055082,GO:0055083,GO:0060255,GO:0065007,GO:0065008,GO:0065009,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071496,GO:0071944,GO:0072501,GO:0072502,GO:0072505,GO:0072506,GO:0098771,GO:0104004,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186		ko:K02039					ko00000				Bacteria	1MUMI@1224,1RMW5@1236,3XNJ8@561,COG0704@1,COG0704@2	NA|NA|NA	P	Part of the phosphate (Pho) regulon, which plays a key role in phosphate homeostasis. PhoU is essential for the repression of the Pho regulon at high phosphate conditions
C1_03901	316407.85676315	1.4e-145	522.3	Escherichia	bglG	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0097159,GO:1901363		ko:K02538,ko:K03488					ko00000,ko03000				Bacteria	1NHN8@1224,1RR9W@1236,3XR5Z@561,COG3711@1,COG3711@2	NA|NA|NA	K	Mediates the positive regulation of the beta-glucoside (bgl) operon by functioning as a transcriptional antiterminator. This is an RNA-binding protein that recognizes a specific sequence located just upstream of two termination sites within the operon
C1_03902	469008.B21_03550	0.0	1211.1	Escherichia	bglF	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563	2.7.1.192,2.7.1.193,2.7.1.199,2.7.1.201,2.7.1.208	ko:K02749,ko:K02750,ko:K02752,ko:K02753,ko:K02755,ko:K02756,ko:K02757,ko:K02778,ko:K02779,ko:K02790,ko:K02791,ko:K02802,ko:K02803,ko:K02804,ko:K02818,ko:K02819,ko:K11191,ko:K11192	ko00010,ko00500,ko00520,ko02060,ko05111,map00010,map00500,map00520,map02060,map05111	M00265,M00266,M00267,M00268,M00270,M00271,M00272,M00303	R02738,R02780,R04111,R04394,R05132,R05199,R08559	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.1.1,4.A.1.1.10,4.A.1.1.15,4.A.1.1.16,4.A.1.1.2,4.A.1.1.3,4.A.1.1.4,4.A.1.1.5,4.A.1.1.7,4.A.1.1.8,4.A.1.2.11,4.A.1.2.13,4.A.1.2.2,4.A.1.2.3,4.A.1.2.4,4.A.1.2.5,4.A.1.2.6,4.A.1.2.7,4.A.1.2.8		iAPECO1_1312.APECO1_3811,iE2348C_1286.E2348C_4032,iECABU_c1320.ECABU_c48060,iECIAI39_1322.ECIAI39_2574,iECNA114_1301.ECNA114_1668,iECOK1_1307.ECOK1_3087,iECP_1309.ECP_0691,iECS88_1305.ECS88_2978,iECSF_1327.ECSF_1482,iEcHS_1320.EcHS_A3936,iUMN146_1321.UM146_03015,iUTI89_1310.UTI89_C3077,ic_1306.c5339	Bacteria	1MXEG@1224,1RNEG@1236,3XMAD@561,COG1263@1,COG1263@2,COG1264@1,COG1264@2,COG2190@1,COG2190@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in beta-glucoside transport
C1_03903	469008.B21_03549	6.2e-276	956.1	Escherichia	bglB	GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008422,GO:0008706,GO:0015926,GO:0016787,GO:0016798,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901135,GO:1901657	3.2.1.86	ko:K01223	ko00010,ko00500,map00010,map00500		R00839,R05133,R05134	RC00049,RC00171,RC00714	ko00000,ko00001,ko01000		GT1	iSSON_1240.SSON_3054	Bacteria	1MWG6@1224,1RMM2@1236,3XNCY@561,COG2723@1,COG2723@2	NA|NA|NA	G	Catalyzes the hydrolysis of phosphorylated beta- glucosides into glucose-6-phosphate (G-6-P) and aglycone. It has a high affinity for phosphorylated aromatic beta-glucosides (p- nitrophenyl-beta-glucoside, phenyl beta-glucoside, arbutin and phosphorylated salicin), and a low affinity for phosphorylated beta-methyl-glucoside
C1_03904	316407.85676318	0.0	1077.4	Gammaproteobacteria	bglH	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0006950,GO:0006974,GO:0008150,GO:0008643,GO:0009279,GO:0009987,GO:0015144,GO:0015159,GO:0015267,GO:0015288,GO:0015774,GO:0016020,GO:0016021,GO:0019867,GO:0022803,GO:0022829,GO:0022857,GO:0022884,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031975,GO:0032991,GO:0033036,GO:0033037,GO:0033554,GO:0034219,GO:0042956,GO:0042958,GO:0044425,GO:0044462,GO:0044464,GO:0045203,GO:0046930,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071702,GO:0071944,GO:0098796		ko:K02024,ko:K10124					ko00000,ko02000	1.B.3.1.1,1.B.3.1.3		iEC55989_1330.EC55989_4527	Bacteria	1PNS3@1224,1RQTQ@1236,COG4580@1,COG4580@2	NA|NA|NA	M	PFAM porin LamB type
C1_03905	469008.B21_03547	1.5e-107	395.6	Gammaproteobacteria	yieL			ko:K07214					ko00000				Bacteria	1QU4Q@1224,1RZ98@1236,COG2382@1,COG2382@2	NA|NA|NA	P	Belongs to the glycosyl hydrolase 13 family
C1_03906	469008.B21_03547	1.5e-103	382.1	Gammaproteobacteria	yieL			ko:K07214					ko00000				Bacteria	1QU4Q@1224,1RZ98@1236,COG2382@1,COG2382@2	NA|NA|NA	P	Belongs to the glycosyl hydrolase 13 family
C1_03907	316407.85676320	6.1e-134	483.4	Gammaproteobacteria	nagB	GO:0003674,GO:0003824,GO:0004342,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006040,GO:0006044,GO:0006046,GO:0006047,GO:0006048,GO:0006054,GO:0006082,GO:0006139,GO:0006725,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016054,GO:0016787,GO:0016853,GO:0016860,GO:0016861,GO:0016999,GO:0017001,GO:0017144,GO:0018130,GO:0019239,GO:0019262,GO:0019438,GO:0019752,GO:0034641,GO:0034654,GO:0042737,GO:0042802,GO:0043436,GO:0043877,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046348,GO:0046349,GO:0046395,GO:0046483,GO:0055086,GO:0071704,GO:1901071,GO:1901072,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901362,GO:1901575,GO:1901576	3.1.1.31,3.5.99.6	ko:K01057,ko:K02080,ko:K02564	ko00030,ko00052,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00052,map00520,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R00765,R02035,R08365	RC00163,RC00537	ko00000,ko00001,ko00002,ko01000			iB21_1397.B21_02959,iECB_1328.ECB_03008,iECD_1391.ECD_03008,iZ_1308.Z0825	Bacteria	1PJ4E@1224,1S1EI@1236,COG0363@1,COG0363@2	NA|NA|NA	G	glucosamine-6-phosphate deaminase activity
C1_03908	469008.B21_03545	1.7e-118	431.8	Escherichia	cbrC	GO:0002682,GO:0002683,GO:0008150,GO:0008152,GO:0009404,GO:0009605,GO:0009607,GO:0009987,GO:0019748,GO:0030153,GO:0031347,GO:0031348,GO:0035821,GO:0043207,GO:0044003,GO:0044237,GO:0044403,GO:0044413,GO:0044414,GO:0044419,GO:0045088,GO:0045824,GO:0048519,GO:0048583,GO:0048585,GO:0050776,GO:0050777,GO:0050789,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0051832,GO:0051833,GO:0052031,GO:0052037,GO:0052167,GO:0052170,GO:0052173,GO:0052200,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0065007,GO:0075136,GO:0080134		ko:K09925					ko00000				Bacteria	1RC5N@1224,1S2QQ@1236,3XQTG@561,COG3196@1,COG3196@2	NA|NA|NA	S	bacteriocin immunity
C1_03909	198214.SF3744	1.4e-75	288.9	Gammaproteobacteria	yieI												Bacteria	1NJZ6@1224,1SID8@1236,2ERDW@1,33IZG@2	NA|NA|NA		
C1_03910	469008.B21_03543	7.3e-126	456.4	Escherichia	yieH	GO:0000287,GO:0003674,GO:0003824,GO:0003850,GO:0004346,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0030145,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050308,GO:0050309											Bacteria	1NSPA@1224,1RQET@1236,3XMUW@561,COG0637@1,COG0637@2	NA|NA|NA	S	Catalyzes strongly the dephosphorylation of 6- phosphogluconate (6P-Glu) and slightly the dephosphorylation of dihydroxyacetone phosphate (DHAP) and phosphoenolpyruvate (PEP). Also hydrolyzes both purines (GMP and IMP) and pyrimidines as secondary substrates
C1_03911	469008.B21_03542	1.9e-234	818.1	Escherichia	yieG	GO:0003674,GO:0005215,GO:0005345,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006863,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015205,GO:0015207,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015672,GO:0015851,GO:0015853,GO:0016020,GO:0022804,GO:0022857,GO:0022890,GO:0034220,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072530,GO:0098655,GO:0098660,GO:0098662,GO:1902600,GO:1904823		ko:K06901					ko00000,ko02000	2.A.1.40		iECH74115_1262.ECH74115_5145,iECSP_1301.ECSP_4762,iECUMN_1333.ECUMN_4191,iECs_1301.ECs4651,iG2583_1286.G2583_4505,iJO1366.b3714,iY75_1357.Y75_RS18500,iZ_1308.Z5209	Bacteria	1MUV0@1224,1RMBE@1236,3XNC6@561,COG2252@1,COG2252@2	NA|NA|NA	S	Belongs to the xanthine uracil permease family. AzgA purine transporter (TC 2.A.1.40) subfamily
C1_03912	155864.EDL933_5038	2e-100	371.7	Escherichia	yieF	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006805,GO:0008150,GO:0008152,GO:0009410,GO:0009987,GO:0010181,GO:0016491,GO:0016645,GO:0016646,GO:0032553,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0050896,GO:0051716,GO:0052873,GO:0055114,GO:0070887,GO:0071466,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K19784					ko00000				Bacteria	1RAFI@1224,1RYNR@1236,3XP8R@561,COG0431@1,COG0431@2	NA|NA|NA	S	Can also reduce toxic chromate to insoluble and less toxic Cr(3 ). Catalyzes the transfer of three electrons to Cr(6 ) producing Cr(3 ) and one electron to molecular oxygen without producing the toxic Cr(5 ) species and only producing a minimal amount of reactive oxygen species (ROS). Chromate reduction protects the cell against chromate toxicity, but is likely a secondary activity
C1_03913	198214.SF3748	4.1e-141	507.3	Gammaproteobacteria	yieE	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008897,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016780,GO:0019752,GO:0019878,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.8.7	ko:K00997,ko:K06133	ko00770,map00770		R01625	RC00002	ko00000,ko00001,ko01000				Bacteria	1PH34@1224,1RP3Q@1236,COG2091@1,COG2091@2	NA|NA|NA	H	Phosphopantetheinyl transferase
C1_03914	469008.B21_03539	1.5e-183	648.7	Escherichia	yidZ	GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141											Bacteria	1R4F5@1224,1RRRX@1236,3XNGP@561,COG0583@1,COG0583@2	NA|NA|NA	K	Involved in anaerobic NO protection
C1_03915	469008.B21_03538	6.7e-207	726.5	Escherichia	mdtL	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015893,GO:0016020,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944		ko:K07552,ko:K08163,ko:K18552					br01600,ko00000,ko01504,ko02000	2.A.1.2,2.A.1.2.22,2.A.1.2.3			Bacteria	1P8JD@1224,1T1SC@1236,3XMTT@561,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
C1_03916	469008.B21_03537	1.5e-233	815.1	Escherichia	tnaB	GO:0003333,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0015291,GO:0015293,GO:0015711,GO:0015849,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:1903825,GO:1905039		ko:K03834,ko:K03835,ko:K03836,ko:K03837,ko:K03838					ko00000,ko02000	2.A.42.1.1,2.A.42.1.2,2.A.42.1.3,2.A.42.2.1,2.A.42.2.2		iAPECO1_1312.APECO1_3308,iE2348C_1286.E2348C_3406,iEC042_1314.EC042_4066,iEC55989_1330.EC55989_3533,iEC55989_1330.EC55989_3581,iECABU_c1320.ECABU_c35330,iECED1_1282.ECED1_3781,iECIAI1_1343.ECIAI1_3265,iECNA114_1301.ECNA114_4343,iECO103_1326.ECO103_3863,iECO103_1326.ECO103_3910,iECO111_1330.ECO111_3985,iECO26_1355.ECO26_4221,iECO26_1355.ECO26_4267,iECOK1_1307.ECOK1_3543,iECP_1309.ECP_3209,iECSE_1348.ECSE_3400,iECSE_1348.ECSE_3447,iECSF_1327.ECSF_2956,iECUMN_1333.ECUMN_2202,iECW_1372.ECW_m3385,iEKO11_1354.EKO11_0601,iEcE24377_1341.EcE24377A_3643,iLF82_1304.LF82_2232,iNRG857_1313.NRG857_15495,iSBO_1134.SBO_2981,iSDY_1059.SDY_3013,iSFV_1184.SFV_3804,iSFxv_1172.SFxv_4080,iSSON_1240.SSON_3307,iS_1188.S4018,iSbBS512_1146.SbBS512_E3241,iUMN146_1321.UM146_00750,iUTI89_1310.UTI89_C3551,iWFL_1372.ECW_m3385,iY75_1357.Y75_p3461,ic_1306.c3874	Bacteria	1MWGI@1224,1RMME@1236,3XPAV@561,COG0814@1,COG0814@2	NA|NA|NA	E	Involved in tryptophan transport across the cytoplasmic membrane. Plays a role in transporting tryptophan which is to be used catabolically
C1_03917	198214.SF3754	2e-274	951.0	Gammaproteobacteria	tnaA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009034,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016829,GO:0016830,GO:0016846,GO:0019439,GO:0019752,GO:0019842,GO:0022607,GO:0030170,GO:0030955,GO:0031420,GO:0034641,GO:0036094,GO:0042402,GO:0042430,GO:0042436,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044464,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046872,GO:0048037,GO:0050662,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0060187,GO:0065003,GO:0070279,GO:0071704,GO:0071840,GO:0080146,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	4.1.99.1	ko:K01667	ko00380,map00380		R00673	RC00209,RC00355	ko00000,ko00001,ko01000			ic_1306.c4631	Bacteria	1NG5U@1224,1RS6E@1236,COG3033@1,COG3033@2	NA|NA|NA	E	Belongs to the beta-eliminating lyase family
C1_03918	469008.B21_03534	1.2e-252	878.6	Escherichia	mnmE	GO:0000166,GO:0001510,GO:0001882,GO:0001883,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006457,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009268,GO:0009451,GO:0009628,GO:0009636,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0030488,GO:0030955,GO:0031420,GO:0032259,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0061077,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363		ko:K03650			R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016				Bacteria	1MUCQ@1224,1RN5S@1236,3XNA1@561,COG0486@1,COG0486@2	NA|NA|NA	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C1_03919	199310.c4629	0.0	1080.9	Escherichia	yidC	GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0031224,GO:0031226,GO:0032940,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051205,GO:0051234,GO:0051259,GO:0051260,GO:0051641,GO:0061024,GO:0065003,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150		ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9			Bacteria	1MV5M@1224,1RMH1@1236,3XN50@561,COG0706@1,COG0706@2	NA|NA|NA	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins
C1_03920	1440052.EAKF1_ch2229c	1.5e-52	211.8	Escherichia	rnpA	GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005655,GO:0005730,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0030681,GO:0031123,GO:0031404,GO:0031974,GO:0031981,GO:0032991,GO:0033204,GO:0034414,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042301,GO:0042779,GO:0042780,GO:0042781,GO:0043167,GO:0043168,GO:0043170,GO:0043199,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043628,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901681,GO:1902494,GO:1902555,GO:1905267,GO:1905348,GO:1990904	3.1.26.5	ko:K03536,ko:K08998					ko00000,ko01000,ko03016				Bacteria	1MZQE@1224,1S90M@1236,3XPNX@561,COG0594@1,COG0594@2	NA|NA|NA	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
C1_03921	1005994.GTGU_04003	7.1e-15	85.5	Gammaproteobacteria	rpmH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02914	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1NGGS@1224,1SGDJ@1236,COG0230@1,COG0230@2	NA|NA|NA	J	Belongs to the bacterial ribosomal protein bL34 family
C1_03922	316407.85676342	1.6e-263	914.8	Escherichia	dnaA	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010556,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:1990837,GO:2000112		ko:K02313	ko02020,ko04112,map02020,map04112				ko00000,ko00001,ko03032,ko03036				Bacteria	1MU5H@1224,1RNHP@1236,3XNWU@561,COG0593@1,COG0593@2	NA|NA|NA	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C1_03923	155864.EDL933_5024	3.8e-204	717.2	Escherichia	dnaN	GO:0003674,GO:0003824,GO:0003887,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0022616,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Bacteria	1MVD9@1224,1RMNP@1236,3XMYP@561,COG0592@1,COG0592@2	NA|NA|NA	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
C1_03924	155864.EDL933_5023	2.4e-203	714.5	Escherichia	recF	GO:0000731,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0018130,GO:0019438,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901576		ko:K03629	ko03440,map03440				ko00000,ko00001,ko03400				Bacteria	1MX8N@1224,1RN5P@1236,3XNSR@561,COG1195@1,COG1195@2	NA|NA|NA	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C1_03925	155864.EDL933_5022	0.0	1595.9	Escherichia	gyrB	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576	5.99.1.3	ko:K02470					ko00000,ko01000,ko03032,ko03400				Bacteria	1MVKT@1224,1RNB2@1236,3XM6W@561,COG0187@1,COG0187@2	NA|NA|NA	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C1_03926	316407.85676346	9.6e-65	252.7	Escherichia	yidB												Bacteria	1N7FF@1224,1S9KM@1236,3XPQ2@561,COG3753@1,COG3753@2	NA|NA|NA	S	Bacterial protein of unknown function (DUF937)
C1_03927	198214.SF3767	3.2e-147	527.7	Gammaproteobacteria	yidA	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0050308											Bacteria	1MXIH@1224,1RQH8@1236,COG0561@1,COG0561@2	NA|NA|NA	S	member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins
C1_03928	198214.SF3768	5.9e-120	436.8	Gammaproteobacteria	yidX												Bacteria	1RJVW@1224,1S89V@1236,2BBJI@1,3253A@2	NA|NA|NA		
C1_03929	198214.SF3769	1.2e-123	449.1	Gammaproteobacteria	dgoR	GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141		ko:K19776					ko00000,ko03000				Bacteria	1MV83@1224,1RSDC@1236,COG2186@1,COG2186@2	NA|NA|NA	K	transcriptional
C1_03930	198214.SF3770	1.1e-164	585.9	Gammaproteobacteria	dgoK	GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008671,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019520,GO:0019583,GO:0019584,GO:0019752,GO:0032787,GO:0034192,GO:0034194,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046395,GO:0046835,GO:0071704,GO:0072329,GO:1901575	2.7.1.58	ko:K00883	ko00052,ko01100,map00052,map01100	M00552	R03387	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000			iECABU_c1320.ECABU_c41760,iECSE_1348.ECSE_3980,iLF82_1304.LF82_0474,iNRG857_1313.NRG857_18400	Bacteria	1MWGX@1224,1RYZB@1236,COG3734@1,COG3734@2	NA|NA|NA	G	2-keto-3-deoxy-galactonokinase
C1_03931	316407.85676351	7.6e-109	399.8	Escherichia	dgoA	GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0008674,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016830,GO:0016832,GO:0019520,GO:0019583,GO:0019584,GO:0019752,GO:0032787,GO:0034192,GO:0034194,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046395,GO:0071704,GO:0072329,GO:1901575	4.1.2.14,4.1.2.21,4.1.3.42	ko:K01625,ko:K01631	ko00030,ko00052,ko00630,ko01100,ko01120,ko01200,map00030,map00052,map00630,map01100,map01120,map01200	M00008,M00061,M00308,M00552,M00631	R00470,R01064,R05605	RC00307,RC00308,RC00435	ko00000,ko00001,ko00002,ko01000			iECIAI1_1343.ECIAI1_3871,iECO103_1326.ECO103_4465,iECO111_1330.ECO111_4520,iECO26_1355.ECO26_4889,iECW_1372.ECW_m3992,iEKO11_1354.EKO11_0010,iEcE24377_1341.EcE24377A_4202,iUMNK88_1353.UMNK88_4503,iWFL_1372.ECW_m3992,iYL1228.KPN_04096	Bacteria	1RD0T@1224,1RQMK@1236,3XP06@561,COG0800@1,COG0800@2	NA|NA|NA	G	Involved in the degradation of galactose via the DeLey- Doudoroff pathway. Catalyzes the reversible, stereospecific retro- aldol cleavage of 2-keto-3-deoxy-6-phosphogalactonate (KDPGal) to pyruvate and D-glyceraldehyde-3-phosphate. In the synthetic direction, it catalyzes the addition of pyruvate to electrophilic aldehydes with re-facial selectivity. It can use a limited number of aldehyde substrates, including D-glyceraldehyde-3-phosphate (natural substrate), D-glyceraldehyde, glycolaldehyde, 2- pyridinecarboxaldehyde, D-ribose, D-erythrose and D-threose. It efficiently catalyzes aldol addition only using pyruvate as the nucleophilic component and accepts both stereochemical configurations at C2 of the electrophile
C1_03932	316407.85676352	1.1e-225	788.9	Escherichia	dgoD	GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0019520,GO:0019583,GO:0019584,GO:0019752,GO:0032787,GO:0034192,GO:0034194,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046395,GO:0071704,GO:0072329,GO:1901575	4.2.1.6	ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000			iAF1260.b4478,iB21_1397.B21_03519,iBWG_1329.BWG_3382,iEC042_1314.EC042_4048,iEC55989_1330.EC55989_4161,iECBD_1354.ECBD_0011,iECB_1328.ECB_03575,iECDH10B_1368.ECDH10B_3878,iECDH1ME8569_1439.ECDH1ME8569_3579,iECD_1391.ECD_03575,iECIAI1_1343.ECIAI1_3870,iECO103_1326.ECO103_4466,iECO111_1330.ECO111_4519,iECSE_1348.ECSE_3978,iECUMN_1333.ECUMN_4223,iECW_1372.ECW_m3991,iEKO11_1354.EKO11_0011,iETEC_1333.ETEC_3982,iEcDH1_1363.EcDH1_0011,iEcE24377_1341.EcE24377A_4201,iEcSMS35_1347.EcSMS35_4057,iEcolC_1368.EcolC_0011,iJO1366.b4478,iWFL_1372.ECW_m3991,iY75_1357.Y75_RS18645	Bacteria	1MURK@1224,1RPIT@1236,3XMIV@561,COG4948@1,COG4948@2	NA|NA|NA	M	Catalyzes the dehydration of D-galactonate to 2-keto-3- deoxy-D-galactonate
C1_03933	199310.c4612	3.6e-246	857.1	Escherichia	dgoT	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0015711,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0044425,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944		ko:K03535,ko:K08194,ko:K12299					ko00000,ko02000	2.A.1.14.1,2.A.1.14.14,2.A.1.14.7		iECO103_1326.ECO103_4467,iSF_1195.SF3164,iSFxv_1172.SFxv_3474,iSSON_1240.SSON_2946,iS_1188.S3379	Bacteria	1MVPS@1224,1RNMV@1236,3XMSP@561,COG2271@1,COG2271@2	NA|NA|NA	P	Intake of galactonate into the cell
C1_03934	199310.c4611	1.1e-205	722.2	Escherichia	cbrA	GO:0000166,GO:0003674,GO:0005488,GO:0008150,GO:0008152,GO:0009404,GO:0009987,GO:0019748,GO:0030153,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0048037,GO:0050660,GO:0050662,GO:0097159,GO:1901265,GO:1901363											Bacteria	1MXQY@1224,1RZ79@1236,3XM79@561,COG0644@1,COG0644@2	NA|NA|NA	C	bacteriocin immunity
C1_03935	469008.B21_03516	9.9e-246	855.5	Escherichia	yidR	GO:0005975,GO:0005996,GO:0006063,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0019586,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046365,GO:0046395,GO:0046397,GO:0071704,GO:0072329,GO:1901575											Bacteria	1MWDT@1224,1RMFV@1236,3XMAC@561,COG0823@1,COG0823@2	NA|NA|NA	U	galacturonate metabolic process
C1_03936	155864.EDL933_5016	9.7e-42	175.6	Escherichia	yidQ	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716											Bacteria	1MZ8R@1224,1S9TX@1236,3XPW1@561,COG5645@1,COG5645@2	NA|NA|NA	S	cellular response to DNA damage stimulus
C1_03937	1440052.EAKF1_ch2245	1.9e-71	275.0	Escherichia	ibpA	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896		ko:K04080,ko:K04081,ko:K13993	ko04141,map04141				ko00000,ko00001,ko03110				Bacteria	1RH2X@1224,1S6WS@1236,3XPM8@561,COG0071@1,COG0071@2	NA|NA|NA	O	Associates with aggregated proteins, together with IbpB, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK DnaJ GrpE. Its activity is ATP- independent
C1_03938	155864.EDL933_5013	2.2e-75	288.1	Escherichia	ibpB	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0010035,GO:0010038,GO:0042221,GO:0042802,GO:0044424,GO:0044464,GO:0046688,GO:0050896,GO:0097501,GO:1990169		ko:K04080,ko:K04081,ko:K13993	ko04141,map04141				ko00000,ko00001,ko03110				Bacteria	1R9Z9@1224,1S23Z@1236,3XP7K@561,COG0071@1,COG0071@2	NA|NA|NA	O	Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK DnaJ GrpE. Its activity is ATP- independent
C1_03939	155864.EDL933_5011	7.1e-303	1045.8	Escherichia	yidE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03281,ko:K07085					ko00000	2.A.49,2.A.81			Bacteria	1MUVM@1224,1RQY2@1236,3XNHV@561,COG0569@1,COG0569@2,COG2985@1,COG2985@2	NA|NA|NA	P	potassium ion transport
C1_03940	316407.85676360	7.9e-126	456.4	Escherichia	yidP	GO:0003674,GO:0003700,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006810,GO:0006950,GO:0008150,GO:0008152,GO:0008643,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051179,GO:0051234,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071702,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K03482,ko:K03710,ko:K11922					ko00000,ko03000				Bacteria	1MUEB@1224,1RN2J@1236,3XQQU@561,COG2188@1,COG2188@2	NA|NA|NA	K	transcriptional regulator
C1_03941	155864.EDL933_5009	1.2e-302	1045.0	Escherichia	glvC		2.7.1.192,2.7.1.193,2.7.1.199,2.7.1.201,2.7.1.208	ko:K02749,ko:K02750,ko:K02752,ko:K02753,ko:K02778,ko:K02779,ko:K02790,ko:K02791,ko:K02802,ko:K02803,ko:K02804,ko:K02818,ko:K02819,ko:K11191,ko:K11192	ko00010,ko00500,ko00520,ko02060,ko05111,map00010,map00500,map00520,map02060,map05111	M00265,M00266,M00267,M00268,M00270,M00272,M00303	R02738,R02780,R04111,R04394,R05132,R05199,R08559	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.1.1,4.A.1.1.10,4.A.1.1.15,4.A.1.1.16,4.A.1.1.2,4.A.1.1.3,4.A.1.1.4,4.A.1.1.5,4.A.1.1.7,4.A.1.1.8,4.A.1.2.13,4.A.1.2.3,4.A.1.2.4,4.A.1.2.7,4.A.1.2.8		iECABU_c1320.ECABU_c48060,iECIAI39_1322.ECIAI39_2574,iECIAI39_1322.ECIAI39_2901,iECNA114_1301.ECNA114_1668,iECP_1309.ECP_0691,iECSF_1327.ECSF_1482,ic_1306.c5339	Bacteria	1MU2P@1224,1RNF4@1236,3XP6Q@561,COG1263@1,COG1263@2,COG1264@1,COG1264@2	NA|NA|NA	G	Phosphotransferase system, EIIC
C1_03942	469008.B21_03508	5.8e-112	410.2	Escherichia	aglB		3.2.1.122,3.2.1.22,3.2.1.86	ko:K01222,ko:K01232,ko:K07406	ko00010,ko00052,ko00500,ko00561,ko00600,ko00603,map00010,map00052,map00500,map00561,map00600,map00603		R00837,R00838,R00839,R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05133,R05134,R05549,R05961,R06091,R06113	RC00049,RC00059,RC00171,RC00451,RC00714	ko00000,ko00001,ko01000		GH4,GT4	iECH74115_1262.ECH74115_5633,iECSP_1301.ECSP_5218,iECs_1301.ECs5101	Bacteria	1NI6G@1224,1RYKZ@1236,3XP52@561,COG1486@1,COG1486@2	NA|NA|NA	G	Family 4 glycosyl hydrolase
C1_03943	155864.EDL933_5008	1.6e-24	117.9	Escherichia	aglB		3.2.1.122,3.2.1.22,3.2.1.86	ko:K01222,ko:K01232,ko:K07406	ko00010,ko00052,ko00500,ko00561,ko00600,ko00603,map00010,map00052,map00500,map00561,map00600,map00603		R00837,R00838,R00839,R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05133,R05134,R05549,R05961,R06091,R06113	RC00049,RC00059,RC00171,RC00451,RC00714	ko00000,ko00001,ko01000		GH4,GT4	iECH74115_1262.ECH74115_5633,iECSP_1301.ECSP_5218,iECs_1301.ECs5101	Bacteria	1NI6G@1224,1RYKZ@1236,3XP52@561,COG1486@1,COG1486@2	NA|NA|NA	G	Family 4 glycosyl hydrolase
C1_03944	316407.85676363	6.7e-175	619.8	Escherichia	yidL	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576											Bacteria	1R5IW@1224,1S033@1236,3XRCD@561,COG2207@1,COG2207@2	NA|NA|NA	K	sequence-specific DNA binding
C1_03945	316407.85676364	0.0	1099.3	Gammaproteobacteria	yidK	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0015291,GO:0015293,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944		ko:K03307					ko00000	2.A.21		iECIAI1_1343.ECIAI1_3857,iECO111_1330.ECO111_4504,iECO26_1355.ECO26_4903,iECSE_1348.ECSE_3965,iECW_1372.ECW_m3979,iEKO11_1354.EKO11_0023,iEcE24377_1341.EcE24377A_4187,iWFL_1372.ECW_m3979	Bacteria	1MXWV@1224,1RR4S@1236,COG4146@1,COG4146@2	NA|NA|NA	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1_03946	316407.85676365	9.5e-307	1058.5	Escherichia	yidJ			ko:K01138					ko00000,ko01000				Bacteria	1MV0B@1224,1RMJ0@1236,3XQGB@561,COG3119@1,COG3119@2	NA|NA|NA	P	sulfuric ester hydrolase activity
C1_03947	316407.85676366	2.8e-73	281.2	Escherichia	yidI	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1RHWJ@1224,1S6BM@1236,2B6XT@1,31ZXV@2,3XPNI@561	NA|NA|NA		
C1_03948	155864.EDL933_5003	1.6e-55	221.9	Escherichia	yidH	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0016020,GO:0044464,GO:0050896,GO:0071944		ko:K00389					ko00000				Bacteria	1REUC@1224,1S618@1236,3XPRM@561,COG2149@1,COG2149@2	NA|NA|NA	S	response to oxidative stress
C1_03949	155864.EDL933_5002	2.5e-59	234.6	Escherichia	yidG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1RJVC@1224,1S5YN@1236,2ATH5@1,31J0W@2,3XPVT@561	NA|NA|NA	S	Domain of unknown function (DUF202)
C1_03950	198214.SF3788	9.7e-91	339.3	Gammaproteobacteria	yidF			ko:K06871					ko00000				Bacteria	1NAKI@1224,1T1AF@1236,COG0641@1,COG0641@2	NA|NA|NA	K	radical SAM
C1_03951	316407.85676370	1.4e-215	755.4	Escherichia	emrD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K08154					ko00000,ko02000	2.A.1.2.9			Bacteria	1N0VD@1224,1RN3X@1236,3XPF0@561,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
C1_03954	316407.85676372	0.0	1107.8	Escherichia	ilvB	GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000			iSDY_1059.SDY_4155	Bacteria	1MU6U@1224,1RMQQ@1236,3XM7M@561,COG0028@1,COG0028@2	NA|NA|NA	H	acetolactate synthase
C1_03955	1440052.EAKF1_ch2259	1.6e-48	198.4	Escherichia	ilvN	GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000			iAF1260.b3670,iAPECO1_1312.APECO1_2782,iB21_1397.B21_03496,iBWG_1329.BWG_3361,iE2348C_1286.E2348C_3985,iEC042_1314.EC042_4025,iECABU_c1320.ECABU_c41570,iECBD_1354.ECBD_0033,iECB_1328.ECB_03554,iECDH10B_1368.ECDH10B_3853,iECDH1ME8569_1439.ECDH1ME8569_3555,iECD_1391.ECD_03554,iECED1_1282.ECED1_4366,iECH74115_1262.ECH74115_5103,iECIAI1_1343.ECIAI1_3846,iECIAI39_1322.ECIAI39_4272,iECNA114_1301.ECNA114_3825,iECO111_1330.ECO111_4494,iECO26_1355.ECO26_4913,iECOK1_1307.ECOK1_4123,iECP_1309.ECP_3877,iECS88_1305.ECS88_4095,iECSE_1348.ECSE_3954,iECSF_1327.ECSF_3518,iECSP_1301.ECSP_4721,iECUMN_1333.ECUMN_4201,iECW_1372.ECW_m3968,iECs_1301.ECs4611,iEKO11_1354.EKO11_0033,iETEC_1333.ETEC_3964,iEcDH1_1363.EcDH1_0033,iEcE24377_1341.EcE24377A_4179,iEcHS_1320.EcHS_A3883,iEcSMS35_1347.EcSMS35_4037,iEcolC_1368.EcolC_0029,iG2583_1286.G2583_4464,iJO1366.b3670,iJR904.b3670,iLF82_1304.LF82_1110,iNRG857_1313.NRG857_18305,iPC815.YPO2294,iSSON_1240.SSON_3624,iUMN146_1321.UM146_18560,iUMNK88_1353.UMNK88_4479,iUTI89_1310.UTI89_C4226,iWFL_1372.ECW_m3968,iY75_1357.Y75_RS18770,iYL1228.KPN_04073,iZ_1308.Z5164,ic_1306.c4595	Bacteria	1N065@1224,1S73I@1236,3XPW8@561,COG0440@1,COG0440@2	NA|NA|NA	E	acetolactate synthase
C1_03956	155864.EDL933_4993	1.8e-104	385.2	Escherichia	uhpA	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141		ko:K02282,ko:K07686,ko:K07687,ko:K07688,ko:K07689,ko:K07690,ko:K20264	ko02020,ko02024,ko02025,ko02026,ko05111,ko05133,map02020,map02024,map02025,map02026,map05111,map05133	M00473,M00474,M00475,M00477,M00697,M00818			ko00000,ko00001,ko00002,ko01504,ko02022,ko02035,ko02044				Bacteria	1QW4D@1224,1RVMQ@1236,3XMI5@561,COG2197@1,COG2197@2	NA|NA|NA	K	Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. Activates the transcription of the uhpT gene. Acts by binding specifically to the uhpT promoter region
C1_03957	316407.85676375	4.3e-283	979.9	Escherichia	uhpB	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.7.13.3	ko:K07675,ko:K14988,ko:K20263	ko02020,ko02024,map02020,map02024	M00473,M00522,M00818			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	1QUAD@1224,1RMGY@1236,3XP1Q@561,COG3851@1,COG3851@2	NA|NA|NA	T	Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpB functions as a membrane-associated protein kinase that autophosphorylates in response to interaction with UhpC, and subsequently transfers its phosphate group to the response regulator UhpA. Can also dephosphorylate UhpA
C1_03958	481805.EcolC_0032	1.1e-253	882.1	Escherichia	uhpC	GO:0000160,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0023052,GO:0031224,GO:0031226,GO:0035556,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071944		ko:K02445,ko:K07783	ko02020,map02020				ko00000,ko00001,ko02000	2.A.1.4.3,2.A.1.4.4,2.A.1.4.6			Bacteria	1MX4V@1224,1RMB3@1236,3XN04@561,COG2271@1,COG2271@2	NA|NA|NA	G	Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC senses external glucose-6-phosphate and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB
C1_03959	155864.EDL933_4990	6.4e-257	892.9	Escherichia	uhpT	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015114,GO:0015119,GO:0015291,GO:0015297,GO:0015301,GO:0015315,GO:0015318,GO:0015526,GO:0015605,GO:0015698,GO:0015711,GO:0015712,GO:0015748,GO:0015760,GO:0016020,GO:0022804,GO:0022857,GO:0034220,GO:0035435,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:0099516,GO:1901264,GO:1901505		ko:K02445,ko:K07784	ko02020,map02020				ko00000,ko00001,ko02000	2.A.1.4.1,2.A.1.4.3		iECSF_1327.ECSF_3513	Bacteria	1MXY3@1224,1RYKQ@1236,3XM92@561,COG2271@1,COG2271@2	NA|NA|NA	P	Mediates the exchange of external hexose 6-phosphate and internal inorganic phosphate. Can transport glucose-6-phosphate, fructose-6-phosphate and mannose-6-phosphate. Also catalyzes the neutral exchange of internal and external phosphate
C1_03960	481805.EcolC_0034	0.0	1174.1	Escherichia	ade	GO:0000034,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005506,GO:0006040,GO:0006044,GO:0006046,GO:0006139,GO:0006144,GO:0006145,GO:0006146,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008448,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0016787,GO:0016810,GO:0016811,GO:0016814,GO:0018130,GO:0019213,GO:0019239,GO:0019438,GO:0019439,GO:0030145,GO:0034641,GO:0042221,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0046083,GO:0046100,GO:0046101,GO:0046112,GO:0046113,GO:0046148,GO:0046348,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055086,GO:0055114,GO:0070887,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:0097237,GO:0098754,GO:0098869,GO:1901071,GO:1901072,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1990748	3.5.4.2	ko:K01486	ko00230,ko01100,map00230,map01100		R01244	RC00477	ko00000,ko00001,ko01000			iECUMN_1333.ECUMN_4192,iSFV_1184.SFV_3844,iYO844.BSU14520	Bacteria	1MVFP@1224,1RYZ1@1236,3XPH7@561,COG1001@1,COG1001@2	NA|NA|NA	F	adenine deaminase
C1_03961	198214.SF3797	4.6e-236	823.5	Gammaproteobacteria	yieG	GO:0003674,GO:0005215,GO:0005345,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006863,GO:0008150,GO:0015205,GO:0015207,GO:0015851,GO:0015853,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072530,GO:1904823		ko:K06901					ko00000,ko02000	2.A.1.40		iECH74115_1262.ECH74115_5145,iECOK1_1307.ECOK1_4117,iECSP_1301.ECSP_4762,iECUMN_1333.ECUMN_4191,iECs_1301.ECs4651,iG2583_1286.G2583_4505,iUTI89_1310.UTI89_C4220,iZ_1308.Z5209	Bacteria	1MUV0@1224,1RMBE@1236,COG2252@1,COG2252@2	NA|NA|NA	S	permease
C1_03962	155864.EDL933_4986	3e-78	297.7	Escherichia	yicN												Bacteria	1RBC6@1224,1S3E1@1236,28NJF@1,2ZBKK@2,3XPAP@561	NA|NA|NA	S	Protein of unknown function (DUF1198)
C1_03963	198214.SF3799	3.4e-217	760.8	Gammaproteobacteria	nepI	GO:0003674,GO:0005215,GO:0005337,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0015211,GO:0015858,GO:0015860,GO:0015931,GO:0015932,GO:0016020,GO:0022857,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072530,GO:1901264,GO:1901505,GO:1901642		ko:K03445					ko00000,ko02000	2.A.1.2.26			Bacteria	1MVD0@1224,1RMBW@1236,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
C1_03964	316407.85676382	8.7e-47	192.6	Escherichia	yicS												Bacteria	1N3XB@1224,1SAN1@1236,2D8BC@1,32TQY@2,3XQ5W@561	NA|NA|NA		
C1_03965	316407.85676383	3.1e-150	537.7	Escherichia	metQ	GO:0000101,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0008150,GO:0015711,GO:0015821,GO:0015849,GO:0016020,GO:0016021,GO:0030288,GO:0030313,GO:0031224,GO:0031225,GO:0031226,GO:0031975,GO:0032991,GO:0042597,GO:0042940,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0046658,GO:0046942,GO:0048473,GO:0051179,GO:0051234,GO:0055052,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351		ko:K02072,ko:K02073	ko02010,map02010	M00238			ko00000,ko00001,ko00002,ko02000	3.A.1.24		ic_1306.c0238	Bacteria	1MUVY@1224,1RSKH@1236,3XNXN@561,COG1464@1,COG1464@2	NA|NA|NA	M	NLPA lipoprotein
C1_03966	469008.B21_03485	2e-158	565.1	Escherichia	yicL	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1NHTP@1224,1RR5J@1236,3XNDX@561,COG0697@1,COG0697@2	NA|NA|NA	EG	EamA-like transporter family
C1_03967	469008.B21_03484	2.8e-188	664.5	Escherichia	setB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03291					ko00000,ko02000	2.A.1.20		iEC042_1314.EC042_2403,iECDH1ME8569_1439.ECDH1ME8569_0068	Bacteria	1MWWU@1224,1RN2I@1236,3XQFD@561,COG0477@1,COG2814@2	NA|NA|NA	P	sugar efflux transporter
C1_03970	316407.85676386	7.8e-263	912.5	Escherichia	yicJ	GO:0003674,GO:0005215,GO:0005402,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008150,GO:0008324,GO:0008643,GO:0015075,GO:0015077,GO:0015081,GO:0015144,GO:0015154,GO:0015156,GO:0015157,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015487,GO:0015592,GO:0015672,GO:0015765,GO:0015766,GO:0015769,GO:0015772,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034219,GO:0034220,GO:0035725,GO:0043887,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0072348,GO:0098655,GO:0098660,GO:0098662,GO:1901264,GO:1901505,GO:1901656,GO:1901682		ko:K03292,ko:K11104,ko:K16139,ko:K16248					ko00000,ko02000	2.A.2,2.A.2.1		iBWG_1329.BWG_3833,iECDH10B_1368.ECDH10B_4312,iECDH1ME8569_1439.ECDH1ME8569_3979,iEKO11_1354.EKO11_4199,iEcDH1_1363.EcDH1_3872	Bacteria	1MVUM@1224,1RP5J@1236,3XN02@561,COG2211@1,COG2211@2	NA|NA|NA	G	sodium ion transport
C1_03971	362663.ECP_3762	0.0	1630.2	Escherichia	yicI	GO:0003674,GO:0003824,GO:0004553,GO:0005488,GO:0005515,GO:0016787,GO:0016798,GO:0042802,GO:0080176	3.2.1.177	ko:K01811					ko00000,ko01000		GH31		Bacteria	1MWNJ@1224,1RMJ9@1236,3XMXR@561,COG1501@1,COG1501@2	NA|NA|NA	G	Belongs to the glycosyl hydrolase 31 family
C1_03972	481805.EcolC_0056	0.0	1102.4	Escherichia	yicH	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K07289					ko00000				Bacteria	1MU7Y@1224,1RN96@1236,3XMHH@561,COG2982@1,COG2982@2	NA|NA|NA	M	AsmA family
C1_03973	155864.EDL933_4918	2.9e-249	867.5	Escherichia	xanP	GO:0003674,GO:0005215,GO:0005345,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006863,GO:0008150,GO:0015205,GO:0015851,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0042906,GO:0042907,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072530,GO:1904823		ko:K02824,ko:K03458,ko:K09016,ko:K16345,ko:K16346					ko00000,ko02000	2.A.40,2.A.40.1.1,2.A.40.1.2,2.A.40.1.3,2.A.40.4.2,2.A.40.4.3		iECO103_1326.ECO103_1052,iG2583_1286.G2583_3536,iSDY_1059.SDY_4086,iSFxv_1172.SFxv_2795,iS_1188.S2690	Bacteria	1MUN9@1224,1RMGW@1236,3XNJJ@561,COG2233@1,COG2233@2	NA|NA|NA	F	Specific, proton motive force-dependent high-affinity transporter for xanthine
C1_03974	155864.EDL933_4917	1.6e-211	741.9	Escherichia	gltS	GO:0003333,GO:0003674,GO:0005215,GO:0005283,GO:0005310,GO:0005342,GO:0005343,GO:0005416,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006820,GO:0006835,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015077,GO:0015081,GO:0015171,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015501,GO:0015672,GO:0015711,GO:0015849,GO:0016020,GO:0017153,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0044464,GO:0046873,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:1903825,GO:1905039		ko:K03312					ko00000,ko02000	2.A.27		iIT341.HP1506,iPC815.YPO0035,iZ_1308.Z5081	Bacteria	1MVBC@1224,1RP0S@1236,3XM45@561,COG0786@1,COG0786@2	NA|NA|NA	P	Catalyzes the sodium-dependent transport of glutamate
C1_03975	155864.EDL933_4916	6.3e-170	603.2	Gammaproteobacteria													Bacteria	1NT05@1224,1SKT8@1236,2EXA6@1,33QKW@2	NA|NA|NA		
C1_03976	155864.EDL933_4915	0.0	1350.9	Escherichia	recG	GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016020,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494	3.6.4.12	ko:K03655	ko03440,map03440				ko00000,ko00001,ko01000,ko03400				Bacteria	1MWN2@1224,1RMMQ@1236,3XNNB@561,COG1200@1,COG1200@2	NA|NA|NA	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C1_03977	198214.SF3691	5.8e-126	456.8	Gammaproteobacteria	trmH	GO:0001510,GO:0002128,GO:0002938,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008175,GO:0008757,GO:0009020,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0106050,GO:0140098,GO:0140101,GO:1901360	2.1.1.185,2.1.1.34	ko:K00556,ko:K03214,ko:K03218,ko:K03437,ko:K15333					ko00000,ko01000,ko03009,ko03016,ko03036				Bacteria	1MWBE@1224,1RMPR@1236,COG0566@1,COG0566@2	NA|NA|NA	J	Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA
C1_03978	155864.EDL933_4913	0.0	1385.5	Escherichia	spoT	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657	2.7.6.5,3.1.7.2	ko:K00951,ko:K01139	ko00230,map00230		R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009			iECNA114_1301.ECNA114_3794,iECOK1_1307.ECOK1_4092,iECP_1309.ECP_3748,iECS88_1305.ECS88_4065,iECSF_1327.ECSF_3486,iLF82_1304.LF82_2165,iNRG857_1313.NRG857_18145,iUMN146_1321.UM146_18405,iUTI89_1310.UTI89_C4195,ic_1306.c4475	Bacteria	1MU44@1224,1RN3H@1236,3XMC5@561,COG0317@1,COG0317@2	NA|NA|NA	F	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C1_03979	1005994.GTGU_03944	1.6e-39	168.3	Gammaproteobacteria	rpoZ	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030312,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400				Bacteria	1N6TX@1224,1SCSR@1236,COG1758@1,COG1758@2	NA|NA|NA	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
C1_03980	198214.SF3688	2.1e-111	408.3	Gammaproteobacteria	gmk	GO:0003674,GO:0003824,GO:0004385,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.4.8,4.1.1.23	ko:K00942,ko:K01591	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00050,M00051	R00332,R00965,R02090	RC00002,RC00409	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_2813,iIT341.HP0321,iPC815.YPO0040,iSBO_1134.SBO_3729,iSFV_1184.SFV_3881,iSFxv_1172.SFxv_4016,iUTI89_1310.UTI89_C4193	Bacteria	1MW92@1224,1RN09@1236,COG0194@1,COG0194@2	NA|NA|NA	F	Essential for recycling GMP and indirectly, cGMP
C1_03981	469008.B21_03456	0.0	1147.1	Escherichia	ligB	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430		R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400			iEC55989_1330.EC55989_2701,iECIAI1_1343.ECIAI1_2469,iECO103_1326.ECO103_2930,iECO111_1330.ECO111_3141,iECO26_1355.ECO26_3464,iECSE_1348.ECSE_2702,iECW_1372.ECW_m2640,iEKO11_1354.EKO11_1317,iEcE24377_1341.EcE24377A_2698,iWFL_1372.ECW_m2640	Bacteria	1MUZ1@1224,1RN3F@1236,3XMXN@561,COG0272@1,COG0272@2	NA|NA|NA	L	catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction
C1_03982	155864.EDL933_4908	2.3e-105	388.3	Escherichia	yicG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1R9H8@1224,1S00T@1236,3XMVT@561,COG2860@1,COG2860@2	NA|NA|NA	S	UPF0126 domain
C1_03983	155864.EDL933_4907	5.3e-150	537.0	Gammaproteobacteria	dinD	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496		ko:K07741,ko:K14623					ko00000,ko03400				Bacteria	1MVMT@1224,1RYM2@1236,COG3645@1,COG3645@2	NA|NA|NA	S	DNA-damage-inducible protein d
C1_03984	155864.EDL933_4905	8.5e-151	539.7	Escherichia	yicC	GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009022,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:0140101,GO:1901360,GO:1901361,GO:1901575											Bacteria	1MWRA@1224,1RMAB@1236,3XPBQ@561,COG1561@1,COG1561@2	NA|NA|NA	S	Domain of unknown function (DUF1732)
C1_03985	155864.EDL933_4904	1.2e-126	459.1	Escherichia	rph	GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006401,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019439,GO:0022613,GO:0031123,GO:0031125,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0042254,GO:0043170,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:1901361,GO:1901575	2.7.7.56,3.6.1.66	ko:K00989,ko:K02428	ko00230,map00230		R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03016				Bacteria	1MVFZ@1224,1RNTB@1236,3XMIK@561,COG0689@1,COG0689@2	NA|NA|NA	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C1_03986	155864.EDL933_4903	1.2e-114	419.1	Escherichia	pyrE	GO:0000287,GO:0003674,GO:0003824,GO:0004588,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_2819,iECIAI39_1322.ECIAI39_4161,iEcSMS35_1347.EcSMS35_3977,iUTI89_1310.UTI89_C4186	Bacteria	1MW6F@1224,1RQYG@1236,3XNWG@561,COG0461@1,COG0461@2	NA|NA|NA	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C1_03987	155864.EDL933_4902	4.7e-100	370.5	Escherichia	slmA	GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0000918,GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0007049,GO:0007346,GO:0008150,GO:0009295,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0010564,GO:0010948,GO:0010974,GO:0016043,GO:0019219,GO:0019222,GO:0022402,GO:0022607,GO:0031323,GO:0031326,GO:0031333,GO:0032271,GO:0032272,GO:0032465,GO:0032466,GO:0032506,GO:0032954,GO:0032955,GO:0042802,GO:0043085,GO:0043087,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043254,GO:0043547,GO:0043565,GO:0043590,GO:0044085,GO:0044087,GO:0044093,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0045786,GO:0045930,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051252,GO:0051301,GO:0051302,GO:0051336,GO:0051345,GO:0051726,GO:0051782,GO:0060255,GO:0061640,GO:0065007,GO:0065009,GO:0071840,GO:0080090,GO:0090529,GO:0097159,GO:0140110,GO:1901363,GO:1901891,GO:1901892,GO:1902410,GO:1902412,GO:1902413,GO:1903047,GO:1903436,GO:1903437,GO:1903506,GO:1990837,GO:2000112,GO:2001141		ko:K05501					ko00000,ko03000,ko03036				Bacteria	1MWF7@1224,1RPZ6@1236,3XNEV@561,COG1309@1,COG1309@2	NA|NA|NA	K	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions
C1_03988	155864.EDL933_4901	1.7e-81	308.5	Escherichia	dut	GO:0000166,GO:0000287,GO:0001882,GO:0001884,GO:0002134,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019103,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0022607,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0051259,GO:0051260,GO:0055086,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901136,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.6.1.23,4.1.1.36,6.3.2.5	ko:K01520,ko:K13038	ko00240,ko00770,ko00983,ko01100,map00240,map00770,map00983,map01100	M00053,M00120	R02100,R03269,R04231,R11896	RC00002,RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000,ko03400				Bacteria	1RA7P@1224,1S233@1236,3XND3@561,COG0756@1,COG0756@2	NA|NA|NA	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
C1_03989	155864.EDL933_4900	3.7e-224	783.9	Escherichia	coaBC	GO:0000166,GO:0003674,GO:0003824,GO:0004632,GO:0004633,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0010181,GO:0015936,GO:0015937,GO:0016829,GO:0016830,GO:0016831,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032553,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.1.1.36,6.3.2.5	ko:K01598,ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000			iEC042_1314.EC042_3945,iECUMN_1333.ECUMN_4154,iJN746.PP_5285,iSBO_1134.SBO_3641	Bacteria	1MVQP@1224,1RMKQ@1236,3XN0I@561,COG0452@1,COG0452@2	NA|NA|NA	F	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C1_03990	155864.EDL933_4899	8.7e-119	433.0	Escherichia	radC			ko:K03630					ko00000				Bacteria	1MXZ5@1224,1RP86@1236,3XMBP@561,COG2003@1,COG2003@2	NA|NA|NA	E	Belongs to the UPF0758 family. YicR subfamily
C1_03991	198214.SF3676	5.5e-36	156.4	Gammaproteobacteria	rpmB	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02902	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1MZ57@1224,1S8UG@1236,COG0227@1,COG0227@2	NA|NA|NA	J	Belongs to the bacterial ribosomal protein bL28 family
C1_03992	1076550.LH22_02755	1.2e-21	108.2	Pantoea	rpmG	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046677,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02913	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1N6QV@1224,1SCEJ@1236,3W1AP@53335,COG0267@1,COG0267@2	NA|NA|NA	J	there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc
C1_03993	155864.EDL933_4896	4.8e-156	557.0	Escherichia	fpg	GO:0000702,GO:0000703,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008270,GO:0008534,GO:0009987,GO:0016787,GO:0016788,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410				ko00000,ko00001,ko01000,ko03400				Bacteria	1MVM5@1224,1RP3J@1236,3XNNS@561,COG0266@1,COG0266@2	NA|NA|NA	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
C1_03994	155864.EDL933_4895	5e-84	317.0	Escherichia	coaD	GO:0003674,GO:0003824,GO:0004595,GO:0005488,GO:0005515,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0015939,GO:0015940,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046390,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000			iPC815.YPO0053,iSDY_1059.SDY_4064	Bacteria	1RD9F@1224,1S41J@1236,3XMRA@561,COG0669@1,COG0669@2	NA|NA|NA	F	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C1_03995	199310.c4457	9.1e-242	842.4	Escherichia	kdtA	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005		GT30	iECNA114_1301.ECNA114_3778,iIT341.HP0957,iUMNK88_1353.UMNK88_4417	Bacteria	1MU9F@1224,1RNBR@1236,3XNZ6@561,COG1519@1,COG1519@2	NA|NA|NA	M	Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of two 3-deoxy-D-manno-octulosonate (Kdo) residues from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide- 1,4'-bisphosphate precursor of lipid A
C1_03996	198214.SF3669	7.7e-202	709.5	Gammaproteobacteria	rfaQ	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:0071967,GO:1901135,GO:1901137,GO:1901576,GO:1903509		ko:K02849	ko00540,ko01100,map00540,map01100	M00080			ko00000,ko00001,ko00002,ko01000,ko01003,ko01005		GT9	iAF1260.b3632,iBWG_1329.BWG_3323,iECDH10B_1368.ECDH10B_3814,iJO1366.b3632,iSSON_1240.SSON_3775,iY75_1357.Y75_RS18975	Bacteria	1MYZA@1224,1RR6K@1236,COG0859@1,COG0859@2	NA|NA|NA	M	heptosyltransferase
C1_03997	199310.c4455	1.3e-215	755.4	Escherichia	rfaG	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008610,GO:0008653,GO:0008919,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0046401,GO:0046527,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509		ko:K02844	ko00540,ko01100,map00540,map01100	M00080			ko00000,ko00001,ko00002,ko01000,ko01003,ko01005		GT4	iSDY_1059.SDY_4061	Bacteria	1NE3V@1224,1RQE3@1236,3XNUU@561,COG0438@1,COG0438@2	NA|NA|NA	M	Lipopolysaccharide core biosynthesis protein RfaG
C1_03998	481805.EcolC_0081	1.2e-143	515.8	Escherichia													Bacteria	1MXX9@1224,1RQFJ@1236,3XMKG@561,COG0515@1,COG0515@2	NA|NA|NA	F	Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core
C1_03999	502347.ESCAB7627_4715	2.9e-74	284.6	Escherichia	rfaJ		2.4.1.44,2.4.1.58	ko:K03275,ko:K03278,ko:K03279	ko00540,ko01100,map00540,map01100	M00080	R01994,R01997	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005		GT8		Bacteria	1N9H7@1224,1RQGY@1236,3XQM1@561,COG1442@1,COG1442@2	NA|NA|NA	M	lipopolysaccharide glucosyltransferase II activity
C1_04000	316407.85676414	1.1e-200	705.7	Escherichia	waaB	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008378,GO:0008610,GO:0008653,GO:0008921,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035250,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509		ko:K02840	ko00540,ko01100,map00540,map01100	M00080			ko00000,ko00001,ko00002,ko01000,ko01003,ko01005		GT4		Bacteria	1PDRU@1224,1S0YU@1236,3XQF3@561,COG0438@1,COG0438@2	NA|NA|NA	M	Adds a galactose goup to a glucose group of LPS
C1_04001	316407.85676415	4.3e-194	683.7	Escherichia	rfaI	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008610,GO:0008653,GO:0008919,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0046401,GO:0046527,GO:0047270,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.1.44	ko:K03275,ko:K03276,ko:K03278	ko00540,ko01100,map00540,map01100	M00080	R01994,R01997	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005		GT8		Bacteria	1N9H7@1224,1RQGY@1236,3XQM1@561,COG1442@1,COG1442@2	NA|NA|NA	M	lipopolysaccharide glucosyltransferase II activity
C1_04002	316407.85676416	7.1e-189	666.4	Escherichia	rfaJ	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008610,GO:0008653,GO:0008919,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0046401,GO:0046527,GO:0047270,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.1.44,2.4.1.58	ko:K03275,ko:K03276,ko:K03278,ko:K03279	ko00540,ko01100,map00540,map01100	M00080	R01994,R01997	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005		GT8	iECP_1309.ECP_3726,iSFV_1184.SFV_3904,iSF_1195.SF3664,iSFxv_1172.SFxv_3993,iS_1188.S4104	Bacteria	1MUEC@1224,1RMCM@1236,3XQE2@561,COG1442@1,COG1442@2	NA|NA|NA	M	Lipopolysaccharide 1,2-glucosyltransferase
C1_04003	316407.85676417	1.1e-121	442.6	Escherichia	rfaY	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0044237		ko:K02850	ko00540,ko01100,map00540,map01100	M00080			ko00000,ko00001,ko00002,ko01000,ko01005				Bacteria	1QYXJ@1224,1T3WV@1236,3XRNG@561,COG3642@1,COG3642@2	NA|NA|NA	T	Catalyzes the phosphorylation of heptose(II) of the outer membrane lipopolysaccharide core
C1_04004	316407.85676418	7.9e-149	533.1	Escherichia	rfaZ	GO:0000271,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0046401,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509		ko:K12981	ko00540,map00540				ko00000,ko00001,ko01000,ko01003,ko01005		GT73		Bacteria	1R5PS@1224,1RXZJ@1236,2DB7S@1,2Z7NB@2,3XQVX@561	NA|NA|NA	J	lipopolysaccharide core region biosynthetic process
C1_04005	316407.85676419	2.3e-201	708.0	Escherichia	waaU	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0008610,GO:0008653,GO:0008713,GO:0008917,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509		ko:K03277	ko00540,ko01100,map00540,map01100				ko00000,ko00001,ko01000,ko01003,ko01005			iAF1260.b3623,iBWG_1329.BWG_3314,iECDH10B_1368.ECDH10B_3805,iECDH1ME8569_1439.ECDH1ME8569_3508,iEcDH1_1363.EcDH1_0082,iJO1366.b3623,iY75_1357.Y75_RS19020	Bacteria	1MYTQ@1224,1SYM4@1236,3XRAE@561,COG0859@1,COG0859@2	NA|NA|NA	M	Adds the terminal N-acetyl-D-glucosamine group on the glucose(II) group of LPS
C1_04006	316407.85676420	1.8e-205	721.8	Gammaproteobacteria	rfaL	GO:0000271,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046401,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509		ko:K02847	ko00540,ko01100,map00540,map01100	M00080			ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	9.B.67.4,9.B.67.5			Bacteria	1R7C4@1224,1RSH3@1236,COG3307@1,COG3307@2	NA|NA|NA	M	O-antigen ligase
C1_04007	316407.85676421	1.1e-178	632.5	Escherichia	rfaC	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509		ko:K02841	ko00540,ko01100,map00540,map01100	M00080			ko00000,ko00001,ko00002,ko01000,ko01003,ko01005		GT9	iB21_1397.B21_03429,iECBD_1354.ECBD_0105,iECB_1328.ECB_03478,iECD_1391.ECD_03478,iECNA114_1301.ECNA114_3774,iECSF_1327.ECSF_3456,iSF_1195.SF3661,iS_1188.S4107	Bacteria	1MYZA@1224,1RPMN@1236,3XMT5@561,COG0859@1,COG0859@2	NA|NA|NA	M	lipopolysaccharide
C1_04008	198214.SF3660	4e-203	713.8	Gammaproteobacteria	rfaF	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509		ko:K02843	ko00540,ko01100,map00540,map01100	M00080			ko00000,ko00001,ko00002,ko01000,ko01003,ko01005		GT9	iECH74115_1262.ECH74115_4993,iECSP_1301.ECSP_4617,iECs_1301.ECs4498,iG2583_1286.G2583_4359,iZ_1308.Z5047	Bacteria	1MXA2@1224,1RMBF@1236,COG0859@1,COG0859@2	NA|NA|NA	M	heptosyltransferase
C1_04009	155864.EDL933_4883	6.8e-178	629.8	Escherichia	hldD	GO:0000166,GO:0000271,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008712,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016853,GO:0016854,GO:0016857,GO:0033692,GO:0034637,GO:0034645,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0048037,GO:0050661,GO:0050662,GO:0070401,GO:0071704,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901576,GO:1903509	5.1.3.20	ko:K03274	ko00540,ko01100,map00540,map01100	M00064	R05176	RC01291	ko00000,ko00001,ko00002,ko01000,ko01005			iPC815.YPO0058,iYL1228.KPN_03963	Bacteria	1MVE4@1224,1RP2S@1236,3XNDJ@561,COG0451@1,COG0451@2	NA|NA|NA	F	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose
C1_04010	155864.EDL933_4881	5.2e-223	780.0	Escherichia	kbl	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0016874,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.3.1.29,2.3.1.47	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03210,R10124	RC00004,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007			iECW_1372.ECW_m3896,iEKO11_1354.EKO11_0103,iPC815.YPO0059,iWFL_1372.ECW_m3896	Bacteria	1MVVH@1224,1RNS6@1236,3XNF2@561,COG0156@1,COG0156@2	NA|NA|NA	H	Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA
C1_04011	198214.SF3656	1.3e-198	698.7	Gammaproteobacteria	tdh	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006566,GO:0006567,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0008652,GO:0008743,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030145,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0046870,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	1.1.1.103	ko:K00060	ko00260,map00260		R01465	RC00525	ko00000,ko00001,ko01000			iEC042_1314.EC042_3926,iECUMN_1333.ECUMN_4133,iPC815.YPO0060	Bacteria	1MV9A@1224,1RMNY@1236,COG1063@1,COG1063@2	NA|NA|NA	C	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate
C1_04012	199310.c4441	2.3e-198	698.0	Escherichia	yibD	GO:0003674,GO:0003824,GO:0005575,GO:0006950,GO:0007154,GO:0008150,GO:0008194,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0015020,GO:0016020,GO:0016036,GO:0016740,GO:0016757,GO:0016758,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042594,GO:0050896,GO:0051716,GO:0071496		ko:K19354					ko00000,ko01000,ko01003,ko01005		GT2		Bacteria	1N72Z@1224,1RRQJ@1236,3XMEY@561,COG1216@1,COG1216@2	NA|NA|NA	S	glucuronosyltransferase activity
C1_04013	155864.EDL933_4878	4.1e-178	630.6	Escherichia	yibQ			ko:K09798					ko00000				Bacteria	1N3JP@1224,1RNKH@1236,3XN4X@561,COG2861@1,COG2861@2	NA|NA|NA	S	carbohydrate metabolic process
C1_04014	155864.EDL933_4877	5.2e-197	693.7	Escherichia	envC	GO:0000920,GO:0001896,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008219,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0012501,GO:0016020,GO:0016787,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0042546,GO:0042597,GO:0043085,GO:0044085,GO:0044093,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071554,GO:0071840,GO:0071944		ko:K06194,ko:K12943,ko:K21471					ko00000,ko01000,ko01002,ko01011	1.A.34.1.2			Bacteria	1MY3E@1224,1RPQP@1236,3XMXJ@561,COG4942@1,COG4942@2	NA|NA|NA	D	Activator of the cell wall hydrolases AmiA and AmiB. Required for septal murein cleavage and daughter cell separation during cell division. In vitro, exhibits weak endoproteolytic activity on beta-casein
C1_04015	362663.ECP_3713	1.6e-293	1014.6	Escherichia	gpmI	GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0030145,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0043937,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046537,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0050789,GO:0050793,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000			iECSE_1348.ECSE_3895,iJN678.yibO,iJN746.PP_5056	Bacteria	1MUQ1@1224,1RMJE@1236,3XMVW@561,COG0696@1,COG0696@2	NA|NA|NA	F	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C1_04016	155864.EDL933_4875	2.6e-71	274.6	Escherichia	yibN	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122		R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000				Bacteria	1MZ83@1224,1S8ZI@1236,3XNPZ@561,COG0607@1,COG0607@2	NA|NA|NA	P	Rhodanese-like domain
C1_04017	155864.EDL933_4874	2.7e-41	174.1	Escherichia	grxC	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0033218,GO:0042277,GO:0043167,GO:0043168,GO:0043295,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0055114,GO:0072341,GO:1900750,GO:1901681		ko:K03674,ko:K03676					ko00000,ko03110			iAF1260.b0849,iAPECO1_1312.grxC,iB21_1397.B21_00860,iBWG_1329.BWG_0702,iEC55989_1330.EC55989_0894,iECBD_1354.ECBD_2745,iECB_1328.ECB_00854,iECDH10B_1368.ECDH10B_0919,iECDH1ME8569_1439.ECDH1ME8569_0801,iECD_1391.ECD_00854,iECO111_1330.ECO111_0918,iECO26_1355.ECO26_0976,iECSE_1348.ECSE_0907,iECW_1372.ECW_m0957,iEKO11_1354.EKO11_2987,iETEC_1333.ETEC_0916,iEcDH1_1363.EcDH1_2793,iEcE24377_1341.EcE24377A_0921,iJO1366.b0849,iSBO_1134.SBO_0783,iSFV_1184.SFV_0834,iSF_1195.SF0802,iSFxv_1172.SFxv_0871,iSSON_1240.SSON_0834,iS_1188.S0845,iWFL_1372.ECW_m0957,iY75_1357.Y75_RS04415	Bacteria	1N72P@1224,1SCA2@1236,3XPU4@561,COG0695@1,COG0695@2	NA|NA|NA	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C1_04018	155864.EDL933_4873	1.1e-83	315.8	Escherichia	secB	GO:0002790,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006605,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0034613,GO:0042886,GO:0043952,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051082,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0072321		ko:K03071	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044,ko03110	3.A.5			Bacteria	1RI75@1224,1S62H@1236,3XNNZ@561,COG1952@1,COG1952@2	NA|NA|NA	U	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C1_04019	155864.EDL933_4872	3e-187	661.0	Escherichia	gpsA	GO:0003674,GO:0003824,GO:0004367,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006072,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0047952,GO:0052646,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110		R00842,R00844	RC00029	ko00000,ko00001,ko01000			iSFV_1184.SFV_3923	Bacteria	1MUU3@1224,1RPQ7@1236,3XNWW@561,COG0240@1,COG0240@2	NA|NA|NA	I	Glycerol-3-phosphate dehydrogenase
C1_04020	155864.EDL933_4871	3.6e-151	540.8	Escherichia	cysE	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009001,GO:0009058,GO:0009069,GO:0009070,GO:0009314,GO:0009333,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016053,GO:0016407,GO:0016412,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019344,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000				Bacteria	1MVFX@1224,1RNCA@1236,3XNRD@561,COG1045@1,COG1045@2	NA|NA|NA	E	Belongs to the transferase hexapeptide repeat family
C1_04021	155864.EDL933_4870	1.3e-87	328.9	Escherichia	trmL	GO:0001510,GO:0002128,GO:0002130,GO:0002131,GO:0002132,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.207	ko:K03216					ko00000,ko01000,ko03016				Bacteria	1RCY4@1224,1S3PI@1236,3XN4Z@561,COG0219@1,COG0219@2	NA|NA|NA	J	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C1_04022	199310.c4427	2.7e-224	784.3	Escherichia	lldD	GO:0000166,GO:0003674,GO:0003824,GO:0004457,GO:0004459,GO:0004460,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005996,GO:0006004,GO:0006082,GO:0006089,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009060,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0010181,GO:0015980,GO:0016020,GO:0016052,GO:0016053,GO:0016310,GO:0016491,GO:0016614,GO:0016616,GO:0016898,GO:0017144,GO:0018130,GO:0019317,GO:0019318,GO:0019320,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019516,GO:0019637,GO:0019693,GO:0019752,GO:0032553,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0042354,GO:0042355,GO:0042866,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044464,GO:0045333,GO:0046031,GO:0046034,GO:0046365,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615	1.1.2.3	ko:K00101	ko00620,ko01100,map00620,map01100		R00196	RC00044	ko00000,ko00001,ko01000			iECOK1_1307.ECOK1_4049,iJN746.PP_4736	Bacteria	1MUEZ@1224,1RPA1@1236,3XP35@561,COG1304@1,COG1304@2	NA|NA|NA	C	Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain
C1_04023	198214.SF3643	7.2e-141	506.5	Gammaproteobacteria	lldR	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0043565,GO:0050896,GO:0051716,GO:0097159,GO:1901363		ko:K14348					ko00000,ko03000				Bacteria	1QHAH@1224,1SYG2@1236,COG2186@1,COG2186@2	NA|NA|NA	K	Represses the lctPRD operon
C1_04024	155864.EDL933_4867	9.5e-308	1062.0	Escherichia	lldP	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006950,GO:0006974,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015672,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0033554,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600		ko:K00427,ko:K02550,ko:K03303					ko00000,ko02000	2.A.14,2.A.14.1.1,2.A.14.1.2		e_coli_core.b3603,iAF1260.b3603,iECDH1ME8569_1439.ECDH1ME8569_3488,iECW_1372.ECW_m3882,iEcDH1_1363.EcDH1_0102,iEcolC_1368.EcolC_0105,iIT341.HP0140,iIT341.HP0141,iJO1366.b3603,iJR904.b3603,iWFL_1372.ECW_m3882,iYL1228.KPN_03947	Bacteria	1MV13@1224,1RPNW@1236,3XNWT@561,COG1620@1,COG1620@2	NA|NA|NA	C	Transports L-lactate across the membrane. Can also transport D-lactate and glycolate. Seems to be driven by a proton motive force
C1_04025	155864.EDL933_4866	0.0	2016.5	Escherichia				ko:K21449					ko00000,ko02000	1.B.40.2			Bacteria	1N338@1224,1RPXV@1236,3XNG0@561,COG5295@1,COG5295@2	NA|NA|NA	UW	Mediates aggregation, biofilm formation and adhesion to a range of extracellular matrix (ECM) proteins, such as fibronectin, fibrinogen, laminin and collagen types I, II, III, and V. Mediates adhesion to
C1_04026	469008.B21_03410	4.4e-118	430.6	Escherichia													Bacteria	1RFVD@1224,1S5KT@1236,2C0YN@1,2ZYYI@2,3XQDP@561	NA|NA|NA	S	Protein of unknown function (DUF3251)
C1_04027	155864.EDL933_4864	1.1e-54	219.2	Escherichia	yibL	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K14762					ko00000,ko03009				Bacteria	1RJ19@1224,1S5V8@1236,2AN7V@1,31D5W@2,3XPSG@561	NA|NA|NA	S	Protein of unknown function (DUF2810)
C1_04028	155864.EDL933_4863	7.3e-32	142.5	Escherichia	yibT	GO:0001101,GO:0008150,GO:0010033,GO:0042221,GO:0050896,GO:0097305,GO:1901422,GO:1901700											Bacteria	1N93Z@1224,1SD4V@1236,2E4DS@1,32Z93@2,3XQ0F@561	NA|NA|NA	S	response to butan-1-ol
C1_04029	155864.EDL933_4862	9.4e-101	372.9	Escherichia	mtlR	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K02562					ko00000,ko03000				Bacteria	1NEDY@1224,1RPCM@1236,3XNUX@561,COG3722@1,COG3722@2	NA|NA|NA	K	Involved in the repression of the expression of the mannitol mtlADR operon. Does not bind the operator promoter regulatory region of this operon. Therefore, seems to belong to a new class of transcription factors in bacteria that may regulate gene expression indirectly, perhaps as a part of a larger transcriptional complex
C1_04030	198214.SF3634	7.5e-211	739.6	Gammaproteobacteria	mtlD	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006059,GO:0006066,GO:0008150,GO:0008152,GO:0008926,GO:0009056,GO:0009987,GO:0016052,GO:0016491,GO:0016614,GO:0016616,GO:0019400,GO:0019405,GO:0019407,GO:0019592,GO:0019594,GO:0019751,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046164,GO:0046174,GO:0055114,GO:0071704,GO:1901575,GO:1901615,GO:1901616	1.1.1.17	ko:K00009	ko00051,map00051		R02703	RC00085	ko00000,ko00001,ko01000			iSBO_1134.SBO_3598,iSbBS512_1146.SbBS512_E4017	Bacteria	1MXV8@1224,1RPCP@1236,COG0246@1,COG0246@2	NA|NA|NA	C	Mannitol-1-Phosphate 5-Dehydrogenase
C1_04031	481805.EcolC_0113	0.0	1224.2	Escherichia	mtlA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0015166,GO:0015318,GO:0015575,GO:0015791,GO:0015797,GO:0015850,GO:0016020,GO:0016021,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034219,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090565,GO:1901618	2.7.1.197,2.7.1.202	ko:K02768,ko:K02769,ko:K02770,ko:K02798,ko:K02799,ko:K02800	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273,M00274	R02704,R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1,4.A.2.1.12,4.A.2.1.2,4.A.2.1.24,4.A.2.1.5		iAPECO1_1312.APECO1_2858,iEC042_1314.EC042_3906,iECIAI39_1322.ECIAI39_4114,iECOK1_1307.ECOK1_4040,iECS88_1305.ECS88_4012,iECUMN_1333.ECUMN_4110,iUMN146_1321.UM146_18140,iUTI89_1310.UTI89_C4137	Bacteria	1MUPU@1224,1RNAG@1236,3XME2@561,COG2213@1,COG2213@2,COG4668@1,COG4668@2	NA|NA|NA	G	PTS system mannitol-specific
C1_04032	481805.EcolC_0114	1.8e-62	245.0	Escherichia	yibI	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1N0NJ@1224,1S9BM@1236,2CIMK@1,32S89@2,3XPRA@561	NA|NA|NA	S	Protein of unknown function (DUF3302)
C1_04033	155864.EDL933_4857	8.5e-207	726.1	Escherichia	yibH	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0033554,GO:0044464,GO:0050896,GO:0051716,GO:0071944		ko:K03543,ko:K15548,ko:K15549		M00701			ko00000,ko00002,ko02000	8.A.1.1,8.A.1.1.3,8.A.1.7.1			Bacteria	1NAMI@1224,1RP4N@1236,3XP6B@561,COG1566@1,COG1566@2	NA|NA|NA	V	membrane
C1_04034	316407.85676447	1.8e-78	298.5	Proteobacteria	yibG	GO:0003674,GO:0006950,GO:0006979,GO:0008047,GO:0008150,GO:0030234,GO:0043085,GO:0044093,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0098772	3.1.1.32,3.1.1.4	ko:K01058,ko:K07126	ko00564,ko00565,ko00590,ko00591,ko00592,ko01100,ko01110,map00564,map00565,map00590,map00591,map00592,map01100,map01110		R01315,R01316,R01317,R02053,R02054,R04034,R07064,R07379,R07387,R07859,R07860	RC00020,RC00037,RC00041,RC00094	ko00000,ko00001,ko01000				Bacteria	1P4XC@1224,COG0790@1,COG0790@2	NA|NA|NA	S	COG0790 FOG TPR repeat, SEL1 subfamily
C1_04035	1440052.EAKF1_ch3017c	4.5e-43	180.3	Escherichia		GO:0005575,GO:0005623,GO:0008150,GO:0009279,GO:0009405,GO:0016020,GO:0019867,GO:0030260,GO:0030312,GO:0030313,GO:0031975,GO:0044403,GO:0044409,GO:0044419,GO:0044462,GO:0044464,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0071944		ko:K07483					ko00000				Bacteria	1RHBZ@1224,1S69Y@1236,3XR2P@561,COG2963@1,COG2963@2	NA|NA|NA	L	transposase activity
C1_04036	316407.1736794	7.5e-171	606.3	Gammaproteobacteria		GO:0008150,GO:0009987,GO:0032196		ko:K07497					ko00000				Bacteria	1MVXQ@1224,1RR4F@1236,COG2801@1,COG2801@2	NA|NA|NA	L	COG2801 Transposase and inactivated derivatives
C1_04037	469008.B21_03401	7.8e-67	259.6	Bacteria	yibJ												Bacteria	COG3209@1,COG3209@2	NA|NA|NA	M	self proteolysis
C1_04038	316407.85676449	2.5e-155	554.7	Escherichia	yibA	GO:0006950,GO:0006974,GO:0008150,GO:0009314,GO:0009628,GO:0009987,GO:0033554,GO:0042221,GO:0046677,GO:0050896,GO:0051716											Bacteria	1NB0I@1224,1SV0F@1236,3XR9A@561,COG1413@1,COG1413@2	NA|NA|NA	C	response to radiation
C1_04039	316407.85676450	0.0	2466.4	Escherichia	rhsA	GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010438,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042594,GO:0050896,GO:0051716,GO:0071496											Bacteria	1MVV1@1224,1SKYM@1236,3XQSX@561,COG3209@1,COG3209@2	NA|NA|NA	M	Rhs elements have a nonessential function. They may play an important role in the natural ecology of the cell
C1_04040	199310.c4413	2.2e-108	398.3	Escherichia	yibF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418		R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2			Bacteria	1RHSK@1224,1RR26@1236,3XM6X@561,COG0625@1,COG0625@2	NA|NA|NA	O	Glutathione S-transferase, C-terminal domain
C1_04041	155864.EDL933_4851	3.4e-250	870.5	Escherichia	selA	GO:0003674,GO:0003824,GO:0004125,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009059,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0019752,GO:0019842,GO:0030170,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0090304,GO:0097056,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970		R08219	RC01246	ko00000,ko00001,ko01000			iECP_1309.ECP_3693,iSbBS512_1146.SbBS512_E4006	Bacteria	1MWXI@1224,1RN73@1236,3XMP2@561,COG1921@1,COG1921@2	NA|NA|NA	J	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis
C1_04042	316407.85676453	0.0	1230.3	Escherichia	selB	GO:0000049,GO:0000166,GO:0001514,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006412,GO:0006414,GO:0006417,GO:0006451,GO:0006518,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009069,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016259,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034248,GO:0034641,GO:0034645,GO:0035368,GO:0035639,GO:0036094,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:2000112		ko:K03833					ko00000,ko03012				Bacteria	1MWXH@1224,1RQJI@1236,3XNXT@561,COG3276@1,COG3276@2	NA|NA|NA	J	Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP
C1_04043	469008.B21_03395	9.8e-211	739.2	Escherichia	yiaY	GO:0003674,GO:0003824,GO:0004022,GO:0008150,GO:0008152,GO:0008743,GO:0016491,GO:0016614,GO:0016616,GO:0055114	1.1.1.1	ko:K13954	ko00010,ko00071,ko00350,ko00625,ko00626,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map01100,map01110,map01120,map01130,map01220		R00623,R00754,R04880,R05233,R05234,R06917,R06927	RC00050,RC00088,RC00099,RC00116,RC00649	ko00000,ko00001,ko01000			iSF_1195.SF3627,iS_1188.S4141	Bacteria	1MVPH@1224,1RMVU@1236,3XP0A@561,COG1454@1,COG1454@2	NA|NA|NA	C	L-threonine 3-dehydrogenase activity
C1_04044	481805.EcolC_0125	3.4e-299	1033.5	Escherichia	aldB	GO:0003674,GO:0003824,GO:0004029,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010033,GO:0016491,GO:0016620,GO:0016903,GO:0033554,GO:0042221,GO:0042493,GO:0045471,GO:0046677,GO:0050896,GO:0051716,GO:0055114,GO:0097305,GO:1901700		ko:K00138,ko:K18370	ko00010,ko00620,ko00640,ko01100,ko01110,ko01120,map00010,map00620,map00640,map01100,map01110,map01120		R00711,R10703	RC00047,RC00545	ko00000,ko00001,ko01000			iSF_1195.SF3626,iSFxv_1172.SFxv_3952,iS_1188.S4142	Bacteria	1MU1V@1224,1RMBQ@1236,3XMIY@561,COG1012@1,COG1012@2	NA|NA|NA	C	Belongs to the aldehyde dehydrogenase family
C1_04045	155864.EDL933_4845	5.2e-53	213.4	Escherichia	yiaW	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1N0NJ@1224,1S9BM@1236,2CIMK@1,32S89@2,3XPRA@561	NA|NA|NA	S	Protein of unknown function (DUF3302)
C1_04046	316407.85676457	9.7e-203	712.6	Escherichia	yiaV	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0015238,GO:0015546,GO:0015711,GO:0015849,GO:0015893,GO:0015906,GO:0016020,GO:0022857,GO:0033554,GO:0042221,GO:0042493,GO:0042886,GO:0042887,GO:0042891,GO:0042895,GO:0042908,GO:0042910,GO:0044464,GO:0045117,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:1901474,GO:1901682,GO:1902599		ko:K03543,ko:K15548,ko:K15549		M00701			ko00000,ko00002,ko02000	8.A.1.1,8.A.1.1.3,8.A.1.7.1			Bacteria	1NAMI@1224,1RP4N@1236,3XP6B@561,COG1566@1,COG1566@2	NA|NA|NA	V	membrane
C1_04047	316407.85676458	3.6e-182	644.0	Gammaproteobacteria	yiaU	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1990837											Bacteria	1R72C@1224,1RRH2@1236,COG0583@1,COG0583@2	NA|NA|NA	K	Transcriptional regulator
C1_04048	155864.EDL933_4842	3e-136	491.1	Escherichia	yiaT	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944		ko:K07274					ko00000,ko02000	9.B.99.1			Bacteria	1MWQN@1224,1RQTM@1236,3XM2G@561,COG3713@1,COG3713@2	NA|NA|NA	M	May serve as a scaffold protein required for the formation of a complex with MrcB PonB and MltA, this complex could play a role in enlargement and septation of the murein sacculus
C1_04049	316407.85676460	1.6e-131	475.3	Escherichia	araD	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006004,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008738,GO:0008742,GO:0008994,GO:0009056,GO:0009058,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0016853,GO:0016854,GO:0016857,GO:0019299,GO:0019301,GO:0019317,GO:0019318,GO:0019320,GO:0019321,GO:0019323,GO:0019324,GO:0019566,GO:0019568,GO:0019569,GO:0019571,GO:0019572,GO:0019637,GO:0019752,GO:0019852,GO:0042354,GO:0042355,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046372,GO:0046373,GO:0046872,GO:0046914,GO:0051167,GO:0051186,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901159,GO:1901575,GO:1901576	4.1.1.104,4.1.2.17,4.1.2.19,5.1.3.4	ko:K01628,ko:K01629,ko:K03077,ko:K22130	ko00040,ko00051,ko00053,ko01100,ko01120,map00040,map00051,map00053,map01100,map01120	M00550	R01785,R02262,R02263,R05850	RC00438,RC00599,RC00603,RC00604,RC01479	ko00000,ko00001,ko00002,ko01000			iECED1_1282.ECED1_3191,iECO111_1330.ECO111_4403,iLF82_1304.LF82_1866,iLF82_1304.LF82_2127,iNRG857_1313.NRG857_17845,iNRG857_1313.NRG857_19475,iSDY_1059.SDY_4367,iSSON_1240.SSON_0067	Bacteria	1MU54@1224,1RMIP@1236,3XQC1@561,COG0235@1,COG0235@2	NA|NA|NA	G	L-ribulose-5-phosphate 4-epimerase
C1_04050	469008.B21_03385	1.1e-163	582.4	Escherichia	sgbU	GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019324,GO:0034015,GO:0044238,GO:0044281,GO:0071704	5.1.3.22	ko:K03079	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R03244	RC00540	ko00000,ko00001,ko00002,ko01000			iEcSMS35_1347.EcSMS35_4668	Bacteria	1MWTD@1224,1RPT6@1236,3XM8E@561,COG3623@1,COG3623@2	NA|NA|NA	G	Catalyzes the isomerization of L-xylulose-5-phosphate to L-ribulose-5-phosphate (Potential). May be involved in the utilization of 2,3-diketo-L-gulonate
C1_04051	469008.B21_03384	4.6e-120	437.2	Escherichia	sgbH	GO:0003674,GO:0003824,GO:0005975,GO:0008150,GO:0008152,GO:0009056,GO:0016052,GO:0016829,GO:0016830,GO:0016831,GO:0033982,GO:0044238,GO:0071704,GO:1901575	4.1.1.85,4.1.2.43	ko:K03078,ko:K08093	ko00030,ko00040,ko00053,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00040,map00053,map00680,map01100,map01120,map01200,map01230	M00345,M00550,M00580	R05338,R07125	RC00421,RC00422,RC01721	ko00000,ko00001,ko00002,ko01000			iAF1260.b4196,iAPECO1_1312.APECO1_2196,iBWG_1329.BWG_3908,iE2348C_1286.E2348C_4519,iECDH10B_1368.ECDH10B_4391,iECDH1ME8569_1439.ECDH1ME8569_4053,iECED1_1282.ECED1_4983,iECIAI1_1343.ECIAI1_4429,iECNA114_1301.ECNA114_4412,iECOK1_1307.ECOK1_4710,iECP_1309.ECP_4441,iECS88_1305.ECS88_4782,iECSE_1348.ECSE_4494,iECSF_1327.ECSF_4082,iEcDH1_1363.EcDH1_3797,iJO1366.b4196,iJR904.b4196,iLF82_1304.LF82_2128,iLF82_1304.LF82_2375,iNRG857_1313.NRG857_17835,iNRG857_1313.NRG857_21325,iUMN146_1321.UM146_21220,iY75_1357.Y75_RS21850	Bacteria	1QWE4@1224,1RRCI@1236,3XMQG@561,COG0269@1,COG0269@2	NA|NA|NA	G	Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. May be involved in the utilization of 2,3- diketo-L-gulonate
C1_04052	316407.85676463	5.4e-294	1016.1	Escherichia	lyx	GO:0000166,GO:0003674,GO:0003824,GO:0004856,GO:0005488,GO:0005524,GO:0005975,GO:0005996,GO:0005997,GO:0005998,GO:0006004,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0008737,GO:0008744,GO:0008993,GO:0009056,GO:0009372,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0019200,GO:0019299,GO:0019301,GO:0019317,GO:0019318,GO:0019320,GO:0019321,GO:0019323,GO:0019324,GO:0019566,GO:0019568,GO:0019571,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042354,GO:0042355,GO:0042710,GO:0042732,GO:0042843,GO:0043167,GO:0043168,GO:0044010,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044764,GO:0046365,GO:0046372,GO:0046835,GO:0051704,GO:0071518,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901575	2.7.1.17,2.7.1.189,2.7.1.5,2.7.1.51,2.7.1.53	ko:K00848,ko:K00854,ko:K00879,ko:K00880,ko:K11216	ko00040,ko00051,ko00053,ko01100,ko01120,ko02024,map00040,map00051,map00053,map01100,map01120,map02024	M00014	R01639,R01901,R01902,R03014,R03241,R07127,R11183	RC00002,RC00017,RC00538	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_2885,iB21_1397.B21_02615,iECB_1328.ECB_02654,iECD_1391.ECD_02654,iECOK1_1307.ECOK1_4011,iECP_1309.ECP_3667,iECS88_1305.ECS88_3982,iEcE24377_1341.EcE24377A_4435,iEcSMS35_1347.EcSMS35_3903,iUMN146_1321.UM146_17990,iUTI89_1310.UTI89_C4105	Bacteria	1MWS5@1224,1RP2G@1236,3XP88@561,COG1070@1,COG1070@2	NA|NA|NA	G	Catalyzes the phosphorylation of L-xylulose and 3-keto- L-gulonate. Is involved in L-lyxose utilization via xylulose, and may also be involved in the utilization of 2,3-diketo-L-gulonate
C1_04053	316407.85676464	2.6e-180	637.9	Escherichia	yiaO	GO:0003674,GO:0005488,GO:0006810,GO:0006950,GO:0006974,GO:0008150,GO:0008643,GO:0009987,GO:0030246,GO:0033554,GO:0034219,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071702		ko:K21395					ko00000,ko02000	2.A.56.1		iECSE_1348.ECSE_3855,iEcE24377_1341.EcE24377A_4076,iUMNK88_1353.UMNK88_4364	Bacteria	1MVHC@1224,1RUFU@1236,3XN4F@561,COG1638@1,COG1638@2	NA|NA|NA	G	Part of the tripartite ATP-independent periplasmic (TRAP) transport system YiaMNO involved in the uptake of 2,3- diketo-L-gulonate. This protein specifically binds 2,3-diketo-L- gulonate. Is not able to bind either L-ascorbate or dehydroascorbate
C1_04054	316407.85676465	1.1e-223	782.3	Escherichia	yiaN	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0016020,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944		ko:K21393					ko00000,ko02000	2.A.56.1		iECABU_c1320.ECABU_c40220,iECNA114_1301.ECNA114_3731,iECO103_1326.ECO103_4656,iECOK1_1307.ECOK1_4026,iECP_1309.ECP_3683,iECSF_1327.ECSF_3414,iLF82_1304.LF82_3342,iNRG857_1313.NRG857_17820,iUMN146_1321.UM146_18065,iUTI89_1310.UTI89_C4121,ic_1306.c4400	Bacteria	1MU0F@1224,1RRZ7@1236,3XN0Q@561,COG1593@1,COG1593@2	NA|NA|NA	P	2,3-diketo-L-gulonate TRAP transporter large permease protein YiaN
C1_04055	316407.85676466	2.5e-80	304.7	Gammaproteobacteria	yiaM	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0016020,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944		ko:K11689,ko:K21394	ko02020,map02020				ko00000,ko00001,ko02000	2.A.56.1			Bacteria	1NBJ4@1224,1SAXN@1236,COG3090@1,COG3090@2	NA|NA|NA	G	TRAP transporter small permease
C1_04056	469008.B21_03379	4.6e-82	310.5	Escherichia	yiaL	GO:0008150,GO:0009314,GO:0009628,GO:0050896		ko:K12112,ko:K19334	ko00052,ko00511,ko01100,map00052,map00511,map01100		R01678	RC00049	ko00000,ko00001,ko02048				Bacteria	1N8IZ@1224,1T0V3@1236,3XP74@561,COG2731@1,COG2731@2	NA|NA|NA	G	response to radiation
C1_04057	198214.SF3619	9.1e-189	666.0	Gammaproteobacteria	dlgD	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0055114	1.1.1.130	ko:K08092,ko:K13574	ko00040,ko00053,map00040,map00053		R02637,R02639	RC00238	ko00000,ko00001,ko01000			iEC55989_1330.EC55989_4032,iECIAI1_1343.ECIAI1_3742,iECO103_1326.ECO103_4659,iECO111_1330.ECO111_4395,iECO26_1355.ECO26_5026,iECSE_1348.ECSE_3851,iECW_1372.ECW_m3849,iEKO11_1354.EKO11_0151,iSF_1195.SF3619,iSFxv_1172.SFxv_3943,iS_1188.S4150,iWFL_1372.ECW_m3849	Bacteria	1MWQY@1224,1RSGK@1236,COG2055@1,COG2055@2	NA|NA|NA	C	Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate
C1_04058	199310.c4395	3.6e-154	550.8	Escherichia	yiaJ	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K19333,ko:K21602					ko00000,ko03000				Bacteria	1MUNW@1224,1RRE5@1236,3XMNS@561,COG1414@1,COG1414@2	NA|NA|NA	K	transcriptional
C1_04059	155864.EDL933_4838	1e-89	335.9	Escherichia	ysaA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0044424,GO:0044464,GO:0055114		ko:K05796,ko:K12136,ko:K15827					ko00000,ko01000			iSSON_1240.SSON_2871	Bacteria	1RAJI@1224,1S1ZU@1236,3XM83@561,COG1142@1,COG1142@2	NA|NA|NA	C	4Fe-4S binding domain
C1_04060	155864.EDL933_4837	3.2e-247	860.5	Escherichia	avtA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009042,GO:0009058,GO:0009078,GO:0009079,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0030632,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.66	ko:K00835	ko00290,ko01100,ko01110,ko01130,map00290,map01100,map01110,map01130		R01215	RC00008,RC00036	ko00000,ko00001,ko01000,ko01007			iEKO11_1354.EKO11_0154,iEcSMS35_1347.EcSMS35_3895	Bacteria	1MVRW@1224,1RNK1@1236,3XNPA@561,COG3977@1,COG3977@2	NA|NA|NA	E	Valine--pyruvate aminotransferase
C1_04061	155864.EDL933_4836	0.0	1417.1	Escherichia	malS	GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0004556,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009311,GO:0009313,GO:0009987,GO:0016052,GO:0016160,GO:0016787,GO:0016798,GO:0030288,GO:0030313,GO:0030978,GO:0030980,GO:0031975,GO:0042597,GO:0043167,GO:0043169,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044464,GO:0046872,GO:0051691,GO:0051692,GO:0071704,GO:1901575	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973		R02108,R02112,R11262		ko00000,ko00001,ko01000		GH13	iECABU_c1320.ECABU_c40140,iECP_1309.ECP_3675,iECSE_1348.ECSE_3847,iPC815.YPO4080,ic_1306.c4392	Bacteria	1MU90@1224,1RQ1S@1236,3XN2F@561,COG0366@1,COG0366@2	NA|NA|NA	G	Since only maltooligosaccharides up to a chain length of 6 glucose units are actively transported through the cytoplasmic membrane via the membrane-bound complex of three proteins, MalF, MalG, and MalK, longer maltooligosaccharides must first be degraded by the periplasmic alpha-amylase, the MalS protein
C1_04062	199310.c4390	7.4e-144	516.5	Escherichia	bax			ko:K03796					ko00000		GH73		Bacteria	1RD3U@1224,1S3RA@1236,3XN6F@561,COG2992@1,COG2992@2	NA|NA|NA	S	amidase activity
C1_04063	155864.EDL933_4834	3.9e-223	780.4	Escherichia	xylR	GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141	5.3.1.12	ko:K01812,ko:K02529,ko:K16210	ko00040,ko01100,map00040,map01100	M00061,M00631	R01482,R01983	RC00376	ko00000,ko00001,ko00002,ko01000,ko02000,ko03000	2.A.2.5			Bacteria	1NYTD@1224,1RNGZ@1236,3XN8D@561,COG1609@1,COG1609@2,COG2207@1,COG2207@2	NA|NA|NA	K	Regulatory protein for the xylBAFGHR operon
C1_04064	155864.EDL933_4833	1.5e-209	735.3	Escherichia	xylH	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005996,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0015144,GO:0015145,GO:0015749,GO:0016020,GO:0016021,GO:0019321,GO:0022857,GO:0031224,GO:0034219,GO:0042732,GO:0044238,GO:0044281,GO:0044425,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704,GO:0071944		ko:K10544	ko02010,map02010	M00215			ko00000,ko00001,ko00002,ko02000	3.A.1.2.4		iEC55989_1330.EC55989_4023	Bacteria	1MXXS@1224,1RNWF@1236,3XP4K@561,COG4214@1,COG4214@2	NA|NA|NA	G	Part of the binding-protein-dependent transport system for D-xylose. Probably responsible for the translocation of the substrate across the membrane
C1_04065	481805.EcolC_0147	6e-288	996.1	Escherichia	xylG	GO:0000166,GO:0003674,GO:0005215,GO:0005488,GO:0005524,GO:0005975,GO:0005996,GO:0006810,GO:0008144,GO:0008150,GO:0008152,GO:0008643,GO:0015144,GO:0015145,GO:0015146,GO:0015148,GO:0015749,GO:0015750,GO:0015753,GO:0017076,GO:0019321,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034219,GO:0035639,GO:0036094,GO:0042732,GO:0043167,GO:0043168,GO:0044238,GO:0044281,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363	3.6.3.17	ko:K10545	ko02010,map02010	M00215			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.4		iECABU_c1320.ECABU_c40100,iECP_1309.ECP_3670,iSF_1195.SF3611,iS_1188.S4158	Bacteria	1MU22@1224,1RMCH@1236,3XPAB@561,COG1129@1,COG1129@2	NA|NA|NA	G	Part of the ABC transporter complex XylFGH involved in xylose import. Responsible for energy coupling to the transport system
C1_04066	199310.c4386	3.2e-178	630.9	Escherichia	xylF	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005975,GO:0005996,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0015749,GO:0015750,GO:0015753,GO:0019321,GO:0030246,GO:0030288,GO:0030313,GO:0031975,GO:0034219,GO:0036094,GO:0042597,GO:0042732,GO:0044238,GO:0044281,GO:0044464,GO:0048029,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704		ko:K10543	ko02010,map02010	M00215			ko00000,ko00001,ko00002,ko02000	3.A.1.2.4		iB21_1397.B21_03369,iECBD_1354.ECBD_0168,iECD_1391.ECD_03418,iEcHS_1320.EcHS_A3769,iEcolC_1368.EcolC_0148,iUTI89_1310.UTI89_C4107,ic_1306.c4386	Bacteria	1MX63@1224,1RRJ3@1236,3XM8D@561,COG4213@1,COG4213@2	NA|NA|NA	G	D-xylose metabolic process
C1_04067	199310.c4385	1.1e-261	908.7	Escherichia	xylA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009045,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0042732,GO:0042843,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046365,GO:0071704,GO:1901575	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100		R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000			iECO26_1355.ECO26_5036,iHN637.CLJU_RS08960,iPC815.YPO4038	Bacteria	1MXS2@1224,1RN5Y@1236,3XMQW@561,COG2115@1,COG2115@2	NA|NA|NA	G	Belongs to the xylose isomerase family
C1_04068	198214.SF3608	1.4e-278	964.9	Gammaproteobacteria	xylB	GO:0003674,GO:0003824,GO:0004856,GO:0005975,GO:0005996,GO:0005997,GO:0005998,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019321,GO:0019323,GO:0042732,GO:0042843,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046365,GO:0046835,GO:0071704,GO:1901575	2.7.1.17,2.7.1.5	ko:K00848,ko:K00854	ko00040,ko00051,ko01100,ko01120,map00040,map00051,map01100,map01120	M00014	R01639,R01902,R03014	RC00002,RC00017,RC00538	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_2885,iEC55989_1330.EC55989_4019,iECIAI1_1343.ECIAI1_3729,iECO103_1326.ECO103_4670,iECO111_1330.ECO111_4384,iECO26_1355.ECO26_5037,iECOK1_1307.ECOK1_4011,iECP_1309.ECP_3667,iECS88_1305.ECS88_3982,iECSE_1348.ECSE_3838,iECW_1372.ECW_m3838,iEKO11_1354.EKO11_0162,iEcE24377_1341.EcE24377A_4435,iUMN146_1321.UM146_17990,iUTI89_1310.UTI89_C4105,iWFL_1372.ECW_m3838	Bacteria	1MW4A@1224,1RR7X@1236,COG1070@1,COG1070@2	NA|NA|NA	G	xylulose kinase
C1_04069	155864.EDL933_4828	2.2e-54	218.0	Escherichia	yiaA	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033554,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0071944											Bacteria	1NE4E@1224,1SFCV@1236,3XRGV@561,COG4682@1,COG4682@2	NA|NA|NA	S	yiaA/B two helix domain
C1_04070	155864.EDL933_4827	2.5e-74	284.6	Escherichia	yiaA	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033554,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0071944											Bacteria	1RH8F@1224,1S6WM@1236,3XQIU@561,COG4682@1,COG4682@2	NA|NA|NA	S	cellular response to DNA damage stimulus
C1_04071	198214.SF3605	1.6e-185	655.2	Gammaproteobacteria	wecH	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0008374,GO:0009058,GO:0009059,GO:0009246,GO:0009987,GO:0016020,GO:0016051,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046378,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576											Bacteria	1PX98@1224,1RMGG@1236,COG3274@1,COG3274@2	NA|NA|NA	S	Responsible for the incorporation of O-acetyl groups into the enterobacterial common antigen (ECA) trisaccharide repeat units
C1_04072	155864.EDL933_4825	7.2e-49	199.5	Escherichia	ysaB												Bacteria	1N2GI@1224,1SAV9@1236,2CYUU@1,32T4W@2,3XPWG@561	NA|NA|NA	S	YsaB-like lipoprotein
C1_04073	155864.EDL933_4824	3.9e-178	630.6	Escherichia	glyQ	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016874,GO:0016875,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0140098,GO:0140101	6.1.1.14	ko:K01878,ko:K14164	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iAF1260.b3560,iAF987.Gmet_2942,iJO1366.b3560,iPC815.YPO4072,iY75_1357.Y75_RS19360	Bacteria	1MVCJ@1224,1RMYI@1236,3XP5A@561,COG0752@1,COG0752@2	NA|NA|NA	J	glycyl-tRNA synthetase alpha subunit
C1_04074	198214.SF3602	0.0	1317.8	Gammaproteobacteria	glyS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.14	ko:K01879,ko:K14164	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iAPECO1_1312.APECO1_2891,iE2348C_1286.E2348C_3810,iECABU_c1320.ECABU_c40010,iECED1_1282.ECED1_4242,iECH74115_1262.ECH74115_4934,iECNA114_1301.ECNA114_3710,iECOK1_1307.ECOK1_4005,iECP_1309.ECP_3661,iECS88_1305.ECS88_3976,iECSF_1327.ECSF_3393,iECSP_1301.ECSP_4554,iECs_1301.ECs4442,iG2583_1286.G2583_4300,iJN678.glyS,iUMN146_1321.UM146_17960,iUTI89_1310.UTI89_C4099,ic_1306.c4378	Bacteria	1MV2F@1224,1RNR3@1236,COG0751@1,COG0751@2	NA|NA|NA	J	Glycyl-tRNA synthetase beta subunit
C1_04075	362663.ECP_3660	5.3e-30	136.3	Gammaproteobacteria	hokA			ko:K18919,ko:K18920					ko00000,ko02048				Bacteria	1NF35@1224,1SFFW@1236,2EFY7@1,337V7@2	NA|NA|NA	S	PFAM Hok gef
C1_04076	1028307.EAE_06080	3e-33	147.1	Enterobacter	cspA	GO:0001072,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003723,GO:0003727,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043242,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0060567,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K03704					ko00000,ko03000				Bacteria	1N6Q5@1224,1SCA7@1236,3X2PC@547,COG1278@1,COG1278@2	NA|NA|NA	K	SMART Cold shock protein
C1_04077	155864.EDL933_4820	8e-45	186.0	Escherichia	yiaG			ko:K07726					ko00000,ko03000				Bacteria	1MZTT@1224,1S95K@1236,3XPXQ@561,COG2944@1,COG2944@2	NA|NA|NA	K	HTH-type transcriptional regulator YiaG
C1_04078	155864.EDL933_4819	1.4e-127	462.2	Escherichia	yiaF	GO:0008150,GO:0009987,GO:0044764,GO:0051704											Bacteria	1QD1H@1224,1RNW1@1236,28M2J@1,2ZAGZ@2,3XMJB@561	NA|NA|NA	S	multi-organism cellular process
C1_04079	155864.EDL933_4818	3.4e-180	637.5	Escherichia	ghrB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0008873,GO:0008875,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016618,GO:0019520,GO:0019522,GO:0019752,GO:0030267,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046176,GO:0046181,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	1.1.1.215,1.1.1.26,1.1.1.43,1.1.1.79,1.1.1.81	ko:K00015,ko:K00032,ko:K00090	ko00030,ko00260,ko00480,ko00620,ko00630,ko01100,ko01110,ko01120,map00030,map00260,map00480,map00620,map00630,map01100,map01110,map01120		R00465,R00717,R01388,R01392,R01739,R02032,R02034	RC00001,RC00031,RC00042,RC00084	ko00000,ko00001,ko01000			iSFV_1184.SFV_3534	Bacteria	1MU2D@1224,1RMGZ@1236,3XNIJ@561,COG1052@1,COG1052@2	NA|NA|NA	CH	Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively
C1_04080	1440052.EAKF1_ch2389c	7.6e-107	393.3	Escherichia	yiaD												Bacteria	1MYBP@1224,1RVRF@1236,3XNTG@561,COG2885@1,COG2885@2	NA|NA|NA	M	Belongs to the ompA family
C1_04081	481805.EcolC_0165	0.0	1599.7	Escherichia	bisC	GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016667,GO:0016671,GO:0030151,GO:0033744,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0055114	1.7.2.3,1.8.5.3	ko:K07306,ko:K07811,ko:K07812,ko:K08351	ko00780,ko00920,ko01100,ko02020,map00780,map00920,map01100,map02020		R09501,R10127	RC02555,RC03056	ko00000,ko00001,ko01000,ko02000	5.A.3.3,5.A.3.4		iEC042_1314.EC042_1073,iECOK1_1307.ECOK1_3996,iEcHS_1320.EcHS_A3752,iEcolC_1368.EcolC_0165,iNRG857_1313.NRG857_09385,iUTI89_1310.UTI89_C4091	Bacteria	1NR6J@1224,1RMVE@1236,3XNDI@561,COG0243@1,COG0243@2	NA|NA|NA	C	This enzyme may serve as a scavenger, allowing the cell to utilize biotin sulfoxide as a biotin source. It reduces a spontaneous oxidation product of biotin, D-biotin D-sulfoxide (BSO or BDS), back to biotin. Also exhibits methionine-(S)-sulfoxide (Met-S-SO) reductase activity, acting specifically on the (S) enantiomer in the free, but not the protein-bound form. It thus plays a role in assimilation of oxidized methionines
C1_04082	198214.SF3584	1.5e-82	312.0	Gammaproteobacteria	yiaC		2.3.1.1,2.3.1.210	ko:K03826,ko:K16704,ko:K22476	ko00220,ko01210,ko01230,map00220,map01210,map01230		R00259	RC00004,RC00064	ko00000,ko00001,ko01000			iECNA114_1301.ECNA114_3928	Bacteria	1MZQ5@1224,1S45R@1236,COG0454@1,COG0456@2	NA|NA|NA	K	acetyltransferase
C1_04083	469008.B21_03350	7.6e-108	396.4	Escherichia	tag		3.2.2.20	ko:K01246	ko03410,map03410				ko00000,ko00001,ko01000,ko03400				Bacteria	1R9X5@1224,1S25K@1236,3XNN4@561,COG2818@1,COG2818@2	NA|NA|NA	L	glycosylase I
C1_04084	198214.SF3583	1e-130	472.6	Gammaproteobacteria	yhjY			ko:K12287,ko:K12686					ko00000,ko02000,ko02044	1.B.12.8			Bacteria	1N2A9@1224,1RSZ5@1236,COG5571@1,COG5571@2	NA|NA|NA	N	outer membrane autotransporter
C1_04085	316407.85676498	3.2e-196	691.0	Escherichia	yhjX	GO:0005575,GO:0005623,GO:0005886,GO:0007154,GO:0008150,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0031667,GO:0031668,GO:0031669,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:0071944		ko:K08177					ko00000,ko02000	2.A.1.11			Bacteria	1MWC7@1224,1RY1W@1236,3XP8V@561,COG2223@1,COG2223@2	NA|NA|NA	P	Part of a nutrient-sensing regulatory network composed of the two-component regulatory systems BtsS BtsR and YpdA YpdB, and their respective target proteins, YjiY and YhjX
C1_04086	316407.85676499	0.0	1122.8	Escherichia	eptB	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008654,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016772,GO:0016776,GO:0016780,GO:0019637,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0043838,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046401,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.7.8.42,2.7.8.43	ko:K03760,ko:K12975,ko:K19353	ko00540,ko01503,map00540,map01503	M00722,M00723	R11204,R11205,R11555,R11556,R11557	RC00002,RC00017,RC00428	ko00000,ko00001,ko00002,ko01000,ko01005			iSSON_1240.SSON_3844	Bacteria	1MWS7@1224,1RMNG@1236,3XPCS@561,COG2194@1,COG2194@2	NA|NA|NA	S	Catalyzes the addition of a phosphoethanolamine (pEtN) moiety to the outer 3-deoxy-D-manno-octulosonic acid (Kdo) residue of a Kdo(2)-lipid A. Phosphatidylethanolamines with one unsaturated acyl group functions as pEtN donors and the reaction releases diacylglycerol
C1_04088	362663.ECP_3647	1.7e-37	162.5	Gammaproteobacteria													Bacteria	1P8M3@1224,1SVC4@1236,28VP7@1,2ZHR6@2	NA|NA|NA		
C1_04089	316407.85676500	0.0	1094.3	Escherichia	dppA	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006810,GO:0006857,GO:0008150,GO:0009987,GO:0015833,GO:0020037,GO:0030288,GO:0030313,GO:0031975,GO:0033218,GO:0042277,GO:0042597,GO:0042886,GO:0042938,GO:0044464,GO:0046906,GO:0048037,GO:0051179,GO:0051234,GO:0061077,GO:0071702,GO:0071705,GO:0097159,GO:1901363		ko:K02035,ko:K12368	ko02010,ko02024,ko02030,map02010,map02024,map02030	M00239,M00324			ko00000,ko00001,ko00002,ko02000	3.A.1.5		iSSON_1240.SSON_3846	Bacteria	1MUZH@1224,1RNES@1236,3XMYT@561,COG0747@1,COG0747@2	NA|NA|NA	E	Dipeptide-binding protein of a transport system that can be subject to osmotic shock. DppA is also required for peptide chemotaxis
C1_04090	199310.c4358	2.2e-185	654.8	Escherichia	dppB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02033,ko:K12369	ko02010,ko02024,map02010,map02024	M00239,M00324			ko00000,ko00001,ko00002,ko02000	3.A.1.5		iECUMN_1333.ECUMN_4053	Bacteria	1MU8Z@1224,1RNJ1@1236,3XMU4@561,COG0601@1,COG0601@2	NA|NA|NA	EP	probably responsible for the translocation of the substrate across the membrane
C1_04091	155864.EDL933_4800	2.4e-148	531.6	Escherichia	dppC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02034,ko:K12370,ko:K13891,ko:K15582,ko:K15586	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00324,M00348,M00439,M00440			ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.11,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25		iAF1260.b1245,iAF1260.b3542,iAPECO1_1312.APECO1_2906,iB21_1397.B21_01229,iB21_1397.B21_03344,iBWG_1329.BWG_3231,iE2348C_1286.E2348C_3790,iEC042_1314.EC042_3848,iEC55989_1330.EC55989_1342,iEC55989_1330.EC55989_3993,iECABU_c1320.ECABU_c08730,iECABU_c1320.ECABU_c39840,iECBD_1354.ECBD_0194,iECBD_1354.ECBD_2377,iECB_1328.ECB_01219,iECB_1328.ECB_03393,iECDH10B_1368.ECDH10B_1307,iECDH10B_1368.ECDH10B_3721,iECDH1ME8569_1439.ECDH1ME8569_1185,iECDH1ME8569_1439.ECDH1ME8569_3422,iECD_1391.ECD_01219,iECD_1391.ECD_03393,iECED1_1282.ECED1_4221,iECH74115_1262.ECH74115_4910,iECIAI1_1343.ECIAI1_1264,iECIAI1_1343.ECIAI1_3700,iECIAI39_1322.ECIAI39_4051,iECNA114_1301.ECNA114_3693,iECO103_1326.ECO103_1345,iECO103_1326.ECO103_4274,iECO111_1330.ECO111_1572,iECO111_1330.ECO111_4358,iECO26_1355.ECO26_1756,iECO26_1355.ECO26_4636,iECOK1_1307.ECOK1_3988,iECP_1309.ECP_0846,iECP_1309.ECP_3643,iECS88_1305.ECS88_3962,iECSE_1348.ECSE_1293,iECSE_1348.ECSE_3815,iECSF_1327.ECSF_3376,iECSP_1301.ECSP_1637,iECSP_1301.ECSP_4533,iECUMN_1333.ECUMN_1542,iECUMN_1333.ECUMN_4052,iECW_1372.ECW_m1337,iECW_1372.ECW_m3808,iECs_1301.ECs1745,iECs_1301.ECs4422,iEKO11_1354.EKO11_0191,iEKO11_1354.EKO11_2607,iETEC_1333.ETEC_1347,iETEC_1333.ETEC_3787,iEcDH1_1363.EcDH1_0170,iEcDH1_1363.EcDH1_2403,iEcE24377_1341.EcE24377A_1393,iEcE24377_1341.EcE24377A_4034,iEcHS_1320.EcHS_A1354,iEcHS_1320.EcHS_A3741,iEcSMS35_1347.EcSMS35_3861,iEcolC_1368.EcolC_0173,iEcolC_1368.EcolC_2383,iG2583_1286.G2583_1517,iG2583_1286.G2583_4279,iJO1366.b1245,iJO1366.b3542,iLF82_1304.LF82_0517,iNRG857_1313.NRG857_17605,iSSON_1240.SSON_1935,iSbBS512_1146.SbBS512_E3843,iUMN146_1321.UM146_17880,iUMNK88_1353.UMNK88_1565,iUMNK88_1353.UMNK88_4323,iUTI89_1310.UTI89_C4080,iWFL_1372.ECW_m1337,iWFL_1372.ECW_m3808,iY75_1357.Y75_RS06515,iY75_1357.Y75_RS19465,iZ_1308.Z2021,iZ_1308.Z4959,ic_1306.c0917,ic_1306.c4357	Bacteria	1MUG0@1224,1RN08@1236,3XM6Q@561,COG1173@1,COG1173@2	NA|NA|NA	EP	probably responsible for the translocation of the substrate across the membrane
C1_04092	155864.EDL933_4799	1e-179	636.0	Escherichia	dppD	GO:0000166,GO:0003674,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008144,GO:0008150,GO:0015232,GO:0015886,GO:0016020,GO:0017076,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901678	3.6.3.24	ko:K02031,ko:K02032,ko:K12371,ko:K15583,ko:K15587	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00324,M00439,M00440			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25		iECIAI1_1343.ECIAI1_1494,iECIAI39_1322.ECIAI39_3960,iEcSMS35_1347.EcSMS35_3763,iSBO_1134.SBO_1821,iYL1228.KPN_03896	Bacteria	1R4KB@1224,1SMBI@1236,3XM53@561,COG0444@1,COG0444@2	NA|NA|NA	EP	Part of the binding-protein-dependent transport system for dipeptides. Probably responsible for energy coupling to the transport system
C1_04093	155864.EDL933_4798	7e-189	666.4	Escherichia	dppF	GO:0000166,GO:0003674,GO:0005215,GO:0005488,GO:0005524,GO:0006810,GO:0008144,GO:0008150,GO:0009314,GO:0009628,GO:0015232,GO:0015886,GO:0017076,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0050896,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901678		ko:K02032,ko:K10823,ko:K12372	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00324,M00439			ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25		iAPECO1_1312.APECO1_362,iEC042_1314.EC042_3846,iECABU_c1320.ECABU_c39820,iECED1_1282.ECED1_4219,iECH74115_1262.ECH74115_2095,iECOK1_1307.ECOK1_1402,iECS88_1305.ECS88_1315,iECSP_1301.ECSP_1968,iECs_1301.ECs2087,iPC815.YPO3999,iSF_1195.SF3575,iSFxv_1172.SFxv_3897,iS_1188.S4195,iUMN146_1321.UM146_10835,iUTI89_1310.UTI89_C1445,iZ_1308.Z2227,ic_1306.c4355	Bacteria	1NU4K@1224,1SKPD@1236,3XMBJ@561,COG4608@1,COG4608@2	NA|NA|NA	P	Belongs to the ABC transporter superfamily
C1_04094	316407.85676505	1.1e-226	792.3	Escherichia	yhjV	GO:0000096,GO:0000098,GO:0001101,GO:0003333,GO:0003674,GO:0005215,GO:0005300,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008152,GO:0008324,GO:0008509,GO:0008514,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009093,GO:0009314,GO:0009628,GO:0009987,GO:0010033,GO:0010243,GO:0015075,GO:0015077,GO:0015078,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015194,GO:0015195,GO:0015196,GO:0015238,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015672,GO:0015711,GO:0015801,GO:0015804,GO:0015807,GO:0015825,GO:0015826,GO:0015827,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0016054,GO:0019752,GO:0022804,GO:0022857,GO:0022889,GO:0022890,GO:0031224,GO:0031226,GO:0032329,GO:0034220,GO:0042221,GO:0042493,GO:0043200,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0044425,GO:0044459,GO:0044464,GO:0046395,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:1901367,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901698,GO:1901700,GO:1902475,GO:1902600,GO:1903825,GO:1905039		ko:K03834,ko:K03835,ko:K03836,ko:K03837,ko:K03838					ko00000,ko02000	2.A.42.1.1,2.A.42.1.2,2.A.42.1.3,2.A.42.2.1,2.A.42.2.2		iAPECO1_1312.APECO1_3308,iE2348C_1286.E2348C_3406,iEC55989_1330.EC55989_3533,iEC55989_1330.EC55989_3581,iECABU_c1320.ECABU_c35330,iECED1_1282.ECED1_3781,iECIAI1_1343.ECIAI1_3265,iECNA114_1301.ECNA114_4343,iECO103_1326.ECO103_3863,iECO103_1326.ECO103_3910,iECO111_1330.ECO111_3985,iECO26_1355.ECO26_4221,iECO26_1355.ECO26_4267,iECOK1_1307.ECOK1_3543,iECP_1309.ECP_3209,iECSE_1348.ECSE_3400,iECSE_1348.ECSE_3447,iECSF_1327.ECSF_2956,iECUMN_1333.ECUMN_2202,iECW_1372.ECW_m3385,iEKO11_1354.EKO11_0601,iEcE24377_1341.EcE24377A_3643,iLF82_1304.LF82_2232,iNRG857_1313.NRG857_15495,iSBO_1134.SBO_2981,iSDY_1059.SDY_3013,iSSON_1240.SSON_3307,iSbBS512_1146.SbBS512_E3241,iUMN146_1321.UM146_00750,iUTI89_1310.UTI89_C3551,iWFL_1372.ECW_m3385,iY75_1357.Y75_p3461,ic_1306.c3874	Bacteria	1PCGR@1224,1RSH4@1236,3XN9W@561,COG0814@1,COG0814@2	NA|NA|NA	E	amino acid transmembrane transport
C1_04095	198214.SF3571	7.3e-12	75.1	Gammaproteobacteria				ko:K18862					ko00000,ko02048				Bacteria	1NH19@1224,1SHTV@1236,2DRFU@1,33BJB@2	NA|NA|NA	S	Toxin Ldr, type I toxin-antitoxin system
C1_04097	198214.SF3571	7.3e-12	75.1	Gammaproteobacteria				ko:K18862					ko00000,ko02048				Bacteria	1NH19@1224,1SHTV@1236,2DRFU@1,33BJB@2	NA|NA|NA	S	Toxin Ldr, type I toxin-antitoxin system
C1_04098	198214.SF3571	7.3e-12	75.1	Gammaproteobacteria				ko:K18862					ko00000,ko02048				Bacteria	1NH19@1224,1SHTV@1236,2DRFU@1,33BJB@2	NA|NA|NA	S	Toxin Ldr, type I toxin-antitoxin system
C1_04099	198214.SF3571	7.3e-12	75.1	Gammaproteobacteria				ko:K18862					ko00000,ko02048				Bacteria	1NH19@1224,1SHTV@1236,2DRFU@1,33BJB@2	NA|NA|NA	S	Toxin Ldr, type I toxin-antitoxin system
C1_04100	155864.EDL933_4794	0.0	1113.2	Escherichia	kbaA	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0022603,GO:0042173,GO:0043937,GO:0043938,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0048518,GO:0048522,GO:0050789,GO:0050793,GO:0050794,GO:0051094,GO:0065007,GO:0071944	2.7.8.42,2.7.8.43	ko:K03760,ko:K06349,ko:K12975,ko:K19353	ko00540,ko01503,map00540,map01503	M00722,M00723	R11204,R11205,R11555,R11556,R11557	RC00002,RC00017,RC00428	ko00000,ko00001,ko00002,ko01000,ko01005			iSSON_1240.SSON_3844	Bacteria	1MWJY@1224,1RN4T@1236,3XNT8@561,COG2194@1,COG2194@2	NA|NA|NA	S	cellulose biosynthetic process
C1_04101	155864.EDL933_4793	6.1e-25	119.4	Escherichia	bcsF												Bacteria	1N7UP@1224,1SDDF@1236,2E541@1,32ZX1@2,3XQ2X@561	NA|NA|NA	S	Cellulose biosynthesis protein BcsF
C1_04102	316407.85676509	1.3e-306	1058.1	Escherichia	bcsE	GO:0000166,GO:0003674,GO:0005488,GO:0008144,GO:0017076,GO:0019001,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0035438,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363											Bacteria	1R485@1224,1RQGD@1236,28JMX@1,2Z9EC@2,3XNE5@561	NA|NA|NA	S	cyclic-di-GMP binding
C1_04103	316407.85676510	3.7e-27	126.7	Escherichia	yhjR	GO:0000271,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016051,GO:0030243,GO:0030244,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0051273,GO:0051274,GO:0071704,GO:0090540,GO:1901576											Bacteria	1NKIS@1224,1SHIW@1236,2DRDK@1,33BAX@2,3XQ50@561	NA|NA|NA	S	bacterial cellulose biosynthetic process
C1_04104	198214.SF3565	5.3e-141	506.9	Gammaproteobacteria	yhjQ			ko:K03496					ko00000,ko03036,ko04812				Bacteria	1MXFI@1224,1RYAG@1236,COG1192@1,COG1192@2	NA|NA|NA	D	Cellulose synthase
C1_04105	316407.85676511	0.0	1774.6	Escherichia	bcsA	GO:0000271,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016020,GO:0016051,GO:0030243,GO:0030244,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0051273,GO:0051274,GO:0071704,GO:0071944,GO:0090540,GO:1901576	2.4.1.12	ko:K00694	ko00500,ko01100,ko02026,map00500,map01100,map02026		R02889	RC00005	ko00000,ko00001,ko01000,ko01003,ko02000	4.D.3.1.2,4.D.3.1.5,4.D.3.1.6	GT2		Bacteria	1MWF8@1224,1RPJ6@1236,3XM9Y@561,COG1215@1,COG1215@2	NA|NA|NA	M	Catalytic subunit of cellulose synthase. It polymerizes uridine 5'-diphosphate glucose to cellulose, which is produced as an extracellular component for mechanical and chemical protection at the onset of the stationary phase, when the cells exhibit multicellular behavior (rdar morphotype). Coexpression of cellulose and thin aggregative fimbriae
C1_04106	481805.EcolC_0185	0.0	1528.8	Escherichia	bcsB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K20541					ko00000,ko02000	4.D.3.1.6			Bacteria	1MWF8@1224,1RPJ6@1236,3XNAD@561,COG1215@1,COG1215@2	NA|NA|NA	M	Binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP)
C1_04107	469008.B21_03332	7.2e-219	766.1	Escherichia	bcsZ	GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005576,GO:0008810,GO:0016787,GO:0016798	3.2.1.4	ko:K01179,ko:K20542	ko00500,ko01100,map00500,map01100		R06200,R11307,R11308		ko00000,ko00001,ko01000		GH5,GH8,GH9		Bacteria	1MW17@1224,1RNEU@1236,3XP70@561,COG3405@1,COG3405@2	NA|NA|NA	G	Belongs to the glycosyl hydrolase 8 (cellulase D) family
C1_04108	481805.EcolC_0187	0.0	2193.3	Escherichia	bcsC		1.8.1.9,2.7.11.1	ko:K00384,ko:K02453,ko:K11912,ko:K14949,ko:K20543	ko00450,ko02025,ko03070,ko05111,ko05152,map00450,map02025,map03070,map05111,map05152	M00331	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko00002,ko01000,ko01001,ko02000,ko02044	1.B.55.3,3.A.15			Bacteria	1MVB8@1224,1RPSN@1236,3XMYE@561,COG0457@1,COG0457@2,COG3118@1,COG3118@2	NA|NA|NA	O	cellulose synthase operon protein C
C1_04109	198214.SF3561	0.0	1232.2	Gammaproteobacteria	yhjK	GO:0003674,GO:0003824,GO:0004112,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008081,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046390,GO:0046483,GO:0052652,GO:0052653,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576											Bacteria	1RGCV@1224,1S1IZ@1236,COG2199@1,COG2199@2,COG2200@1,COG2200@2	NA|NA|NA	T	the EAL-domain portion of HmsP from Y. pestis shows phosphodiesterase activity which is required for the inhibition of biofilm formation
C1_04110	199310.c4340	1.7e-224	785.0	Escherichia	dctA	GO:0003333,GO:0003674,GO:0005215,GO:0005310,GO:0005326,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0006950,GO:0006974,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015138,GO:0015140,GO:0015141,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015238,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015366,GO:0015556,GO:0015672,GO:0015711,GO:0015740,GO:0015741,GO:0015743,GO:0015744,GO:0015800,GO:0015807,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0033554,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0070778,GO:0071422,GO:0071423,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:1902475,GO:1902600,GO:1903825,GO:1905039		ko:K11102,ko:K11103	ko02020,map02020				ko00000,ko00001,ko02000	2.A.23.1.1,2.A.23.1.2,2.A.23.1.3,2.A.23.1.6,2.A.23.1.7		iSDY_1059.SDY_4548	Bacteria	1MU0Q@1224,1RMEN@1236,3XNK8@561,COG1301@1,COG1301@2	NA|NA|NA	C	Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate across the membrane
C1_04111	155864.EDL933_4780	1.3e-284	984.9	Escherichia	yhjJ			ko:K07263					ko00000,ko01000,ko01002				Bacteria	1NAH6@1224,1RNKC@1236,3XN4Q@561,COG0612@1,COG0612@2	NA|NA|NA	S	metallopeptidase activity
C1_04112	155864.EDL933_4779	3.8e-173	614.0	Escherichia	kdgK	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006063,GO:0006064,GO:0006082,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008673,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0019200,GO:0019585,GO:0019586,GO:0019698,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033554,GO:0035639,GO:0036094,GO:0042839,GO:0042840,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046395,GO:0046396,GO:0046397,GO:0046835,GO:0050896,GO:0051716,GO:0071704,GO:0072329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901575	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_2922,iPC815.YPO3990,iUTI89_1310.UTI89_C4058	Bacteria	1MVG2@1224,1RNH5@1236,3XMJV@561,COG0524@1,COG0524@2	NA|NA|NA	G	2-dehydro-3-deoxygluconokinase activity
C1_04113	316407.85676519	1.8e-144	518.5	Escherichia	yhjH	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006355,GO:0008081,GO:0008134,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016787,GO:0016788,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032879,GO:0040012,GO:0040013,GO:0042578,GO:0043392,GO:0043433,GO:0044092,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051090,GO:0051098,GO:0051100,GO:0051101,GO:0051171,GO:0051252,GO:0051270,GO:0051271,GO:0060255,GO:0065007,GO:0065009,GO:0071111,GO:0080090,GO:1902021,GO:1902201,GO:1903506,GO:2000112,GO:2000145,GO:2000146,GO:2000677,GO:2000678,GO:2001141	3.1.4.52	ko:K21086	ko02026,map02026				ko00000,ko00001,ko01000				Bacteria	1N1RI@1224,1RQ03@1236,3XMQ2@561,COG2200@1,COG2200@2	NA|NA|NA	T	A bis-(3'-5') cyclic diguanylic acid (c-di-GMP) phosphodiesterase involved in regulating the levels of c-di-GMP that control cell motility (the flagella) and adhesion (adhesive curli fimbriae). The YhjH effect on flagella is controlled via the c-di-GMP-binding flagellar brake protein YcgR, however curli expression is not regulated via YcgR. Forms a network with different diguanylate cyclases (DosC, YeaJ, YedQ, YegE have been identified) to regulate c-di-GMP levels. Flagellar activity is high at low c-di-GMP levels whereas curli fimbria are induced at high c-di-GMP levels. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria
C1_04114	316407.85676520	0.0	1340.5	Escherichia	yhjG	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0032386,GO:0032879,GO:0032880,GO:0033157,GO:0044464,GO:0050789,GO:0051049,GO:0051223,GO:0060341,GO:0065007,GO:0070201,GO:0071944,GO:0090087,GO:0090313,GO:1903533,GO:1903827,GO:1905475		ko:K07289,ko:K07290					ko00000	9.B.121			Bacteria	1MUAN@1224,1RNZM@1236,3XN25@561,COG2982@1,COG2982@2	NA|NA|NA	M	regulation of protein targeting
C1_04115	316407.85676521	8.3e-238	829.3	Escherichia	yhjE	GO:0003333,GO:0003674,GO:0005215,GO:0005216,GO:0005261,GO:0005267,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006820,GO:0006865,GO:0006950,GO:0006970,GO:0006972,GO:0007154,GO:0007165,GO:0007231,GO:0008028,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0008519,GO:0009628,GO:0009651,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015079,GO:0015101,GO:0015199,GO:0015267,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015530,GO:0015651,GO:0015652,GO:0015653,GO:0015672,GO:0015695,GO:0015696,GO:0015697,GO:0015711,GO:0015718,GO:0015733,GO:0015804,GO:0015824,GO:0015838,GO:0015849,GO:0015850,GO:0016020,GO:0016021,GO:0022803,GO:0022804,GO:0022838,GO:0022857,GO:0022890,GO:0023052,GO:0030001,GO:0031224,GO:0031226,GO:0031460,GO:0033554,GO:0034220,GO:0035524,GO:0042538,GO:0043090,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0046942,GO:0046943,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0065007,GO:0071214,GO:0071470,GO:0071472,GO:0071474,GO:0071475,GO:0071702,GO:0071705,GO:0071804,GO:0071805,GO:0071944,GO:0072337,GO:0072349,GO:0072488,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098660,GO:0098662,GO:0098739,GO:0104004,GO:1901618,GO:1902600,GO:1903825,GO:1905039,GO:1905647		ko:K03761,ko:K03762,ko:K08172,ko:K08173					ko00000,ko02000	2.A.1.6,2.A.1.6.2,2.A.1.6.4,2.A.1.6.6		e_coli_core.b2587,iAF1260.b2587,iAPECO1_1312.APECO1_1067,iB21_1397.B21_02445,iBWG_1329.BWG_2351,iEC55989_1330.EC55989_2218,iEC55989_1330.EC55989_2877,iECBD_1354.ECBD_1093,iECB_1328.ECB_02481,iECDH10B_1368.ECDH10B_2755,iECDH1ME8569_1439.ECDH1ME8569_2514,iECD_1391.ECD_02481,iECIAI1_1343.ECIAI1_2705,iECIAI39_1322.ECIAI39_2795,iECNA114_1301.ECNA114_2055,iECO103_1326.ECO103_3166,iECO111_1330.ECO111_3313,iECO26_1355.ECO26_3634,iECS88_1305.ECS88_2049,iECW_1372.ECW_m2816,iEKO11_1354.EKO11_1146,iETEC_1333.ETEC_2800,iEcDH1_1363.EcDH1_1081,iEcE24377_1341.EcE24377A_2873,iEcolC_1368.EcolC_1090,iJO1366.b2587,iJR904.b2587,iLF82_1304.LF82_2131,iNRG857_1313.NRG857_09945,iSBO_1134.SBO_2619,iSDY_1059.SDY_2830,iSF_1195.SF2649,iSFxv_1172.SFxv_2906,iS_1188.S2822,iUMNK88_1353.UMNK88_3239,iUTI89_1310.UTI89_C4705,iWFL_1372.ECW_m2816,iY75_1357.Y75_RS13520,ic_1306.c5116	Bacteria	1MU46@1224,1RMF0@1236,3XM70@561,COG0477@1,COG0477@2	NA|NA|NA	P	transmembrane transporter activity
C1_04116	155864.EDL933_4775	1.1e-184	652.5	Escherichia	yhjD	GO:0003674,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015920,GO:0016020,GO:0016021,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0033036,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:1901264,GO:1901505		ko:K07058					ko00000				Bacteria	1N04V@1224,1RNIB@1236,3XMFQ@561,COG1295@1,COG1295@2	NA|NA|NA	S	lipopolysaccharide transmembrane transporter activity
C1_04117	469008.B21_03322	5.2e-181	640.2	Escherichia	yhjC	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141		ko:K18900		M00698			ko00000,ko00002,ko01504,ko03000				Bacteria	1MV06@1224,1RPI0@1236,3XNXD@561,COG0583@1,COG0583@2	NA|NA|NA	K	transcriptional regulator
C1_04118	316407.85676524	6.2e-108	396.7	Escherichia	yhjB	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576											Bacteria	1NRJH@1224,1S15H@1236,3XNTW@561,COG2197@1,COG2197@2	NA|NA|NA	K	nucleic acid-templated transcription
C1_04119	198214.SF3550	0.0	1148.7	Gammaproteobacteria	treF	GO:0003674,GO:0003824,GO:0004553,GO:0004555,GO:0005975,GO:0005984,GO:0005991,GO:0005993,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009628,GO:0009987,GO:0015927,GO:0016052,GO:0016787,GO:0016798,GO:0033554,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0046352,GO:0050896,GO:0051716,GO:0071214,GO:0071470,GO:0071474,GO:0071704,GO:0104004,GO:1901575	3.2.1.28	ko:K01194,ko:K03931	ko00500,ko01100,map00500,map01100		R00010	RC00049	ko00000,ko00001,ko00537,ko01000		GH37,GH63	iAF1260.b1197,iB21_1397.B21_01182,iBWG_1329.BWG_1022,iECBD_1354.ECBD_2425,iECB_1328.ECB_01172,iECDH10B_1368.ECDH10B_1250,iECDH1ME8569_1439.ECDH1ME8569_1136,iECD_1391.ECD_01172,iETEC_1333.ETEC_1301,iEcDH1_1363.EcDH1_2451,iEcHS_1320.EcHS_A1301,iEcolC_1368.EcolC_2429,iJO1366.b1197,iJR904.b1197,iSBO_1134.SBO_3518,iY75_1357.Y75_RS06245	Bacteria	1MWSM@1224,1RMFP@1236,COG1626@1,COG1626@2	NA|NA|NA	G	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
C1_04120	481805.EcolC_0199	2.4e-275	954.1	Escherichia	yhjA	GO:0000302,GO:0003674,GO:0003824,GO:0004130,GO:0004601,GO:0005488,GO:0006091,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009061,GO:0009636,GO:0009987,GO:0010035,GO:0015980,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017144,GO:0019645,GO:0020037,GO:0022900,GO:0022904,GO:0042221,GO:0042493,GO:0042542,GO:0042743,GO:0044237,GO:0045333,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051716,GO:0055114,GO:0070887,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1990748	1.11.1.5	ko:K00428					ko00000,ko01000				Bacteria	1MV70@1224,1RPPQ@1236,3XNH5@561,COG1858@1,COG1858@2	NA|NA|NA	C	cytochrome C peroxidase
C1_04121	199310.c4328	1.4e-283	981.5	Escherichia	gadA		4.1.1.15	ko:K01580	ko00250,ko00410,ko00430,ko00650,ko01100,ko01110,ko01120,ko02024,ko04727,ko04940,map00250,map00410,map00430,map00650,map01100,map01110,map01120,map02024,map04727,map04940	M00027	R00261,R00489,R01682,R02466	RC00299	ko00000,ko00001,ko00002,ko01000			iAF1260.b3517,iE2348C_1286.E2348C_3759,iECDH1ME8569_1439.ECDH1ME8569_3396,iEcDH1_1363.EcDH1_0196,iEcolC_1368.EcolC_0200,iJO1366.b3517,iJR904.b3517,iUTI89_1310.UTI89_C1707,ic_1306.c1922	Bacteria	1MX25@1224,1RNSQ@1236,3XMMA@561,COG0076@1,COG0076@2	NA|NA|NA	E	Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria
C1_04122	198214.SF3595	2e-149	535.0	Gammaproteobacteria	gadX	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141		ko:K03755,ko:K11920,ko:K21905,ko:K21906					ko00000,ko03000				Bacteria	1R8WH@1224,1S13W@1236,COG2207@1,COG2207@2	NA|NA|NA	K	Porin thermoregulatory protein envY
C1_04123	155864.EDL933_4766	3.4e-132	477.6	Escherichia	gadW	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141		ko:K03755,ko:K11920,ko:K21905,ko:K21906					ko00000,ko03000				Bacteria	1QIIZ@1224,1TGDT@1236,3XQQ1@561,COG2207@1,COG2207@2	NA|NA|NA	K	Depending on the conditions (growth phase and medium), acts as a positive or negative regulator of gadA and gadBC. Repression occurs directly or via the repression of the expression of gadX. Activation occurs directly by the binding of GadW to the gadA and gadBC promoters
C1_04125	155864.EDL933_4765	0.0	1940.2	Escherichia	acrB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015893,GO:0016020,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944		ko:K18138,ko:K18142,ko:K18899	ko01501,ko01503,map01501,map01503	M00647,M00696,M00697,M00699,M00718			ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2,2.A.6.2.13		iAF1260.b3266,iJO1366.b3266,iZ_1308.Z4627	Bacteria	1MU48@1224,1SK4F@1236,3XMW6@561,COG0841@1,COG0841@2	NA|NA|NA	V	Part of the tripartite efflux system MdtEF-TolC, which confers resistance to
C1_04126	316407.85676531	3.9e-207	727.2	Escherichia	mdtE	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0006869,GO:0008150,GO:0010876,GO:0015238,GO:0015711,GO:0015718,GO:0015721,GO:0015849,GO:0015850,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0032991,GO:0033036,GO:0042221,GO:0042493,GO:0042597,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098796,GO:1902495,GO:1990281,GO:1990351		ko:K03585,ko:K18141,ko:K18898	ko01501,ko01503,map01501,map01503	M00646,M00647,M00696,M00697,M00699,M00718			ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1,8.A.1.6,8.A.1.6.3		iSDY_1059.SDY_0456	Bacteria	1MU78@1224,1SJRC@1236,3XPI0@561,COG0845@1,COG0845@2	NA|NA|NA	M	Part of the tripartite efflux system MdtEF-TolC, which confers resistance to
C1_04128	155864.EDL933_4762	5.5e-92	343.6	Escherichia	gadE	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141		ko:K21907,ko:K21963					ko00000,ko03000				Bacteria	1NS5V@1224,1SM5P@1236,3XQTN@561,COG2771@1,COG2771@2	NA|NA|NA	K	Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci
C1_04129	155864.EDL933_4761	1.1e-93	349.4	Escherichia	hdeD	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009268,GO:0009628,GO:0016020,GO:0044464,GO:0050896,GO:0071944		ko:K21908					ko00000	9.B.36.1.1			Bacteria	1RFV7@1224,1S4XK@1236,3XMX7@561,COG3247@1,COG3247@2	NA|NA|NA	S	response to pH
C1_04130	155864.EDL933_4760	7.5e-55	219.5	Escherichia	hdeA	GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0009268,GO:0009628,GO:0009987,GO:0010447,GO:0042802,GO:0050896,GO:0051087,GO:0051716,GO:0071214,GO:0071467,GO:0071468,GO:0104004		ko:K19777					ko00000,ko03110				Bacteria	1NBBC@1224,1SH1A@1236,2E34D@1,32Y4G@2,3XQZE@561	NA|NA|NA	M	Required for optimal acid stress protection. Exhibits a chaperone-like activity only at low pH by suppressing non- specifically the aggregation of denaturated periplasmic proteins
C1_04131	198214.SF3543	1.8e-56	224.9	Gammaproteobacteria	hdeB	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008150,GO:0009268,GO:0009628,GO:0010447,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0050896,GO:0051082		ko:K19778					ko00000,ko03110				Bacteria	1N783@1224,1SD8J@1236,2EACP@1,334GK@2	NA|NA|NA	M	Required for optimal acid stress protection, which is important for survival of enteric bacteria in the acidic environment of the host stomach. Exhibits a chaperone-like activity at acidic pH by preventing the aggregation of many different periplasmic proteins
C1_04132	316407.85676536	4.5e-112	410.6	Escherichia	yhiD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K07507					ko00000,ko02000	9.B.20			Bacteria	1MURJ@1224,1RPR1@1236,3XQPA@561,COG1285@1,COG1285@2	NA|NA|NA	S	MgtC family
C1_04133	316407.85676537	5.5e-92	343.6	Escherichia	dctR	GO:0006109,GO:0008150,GO:0009894,GO:0010675,GO:0019222,GO:0031323,GO:0031329,GO:0043470,GO:0043471,GO:0050789,GO:0050794,GO:0060255,GO:0065007,GO:0080090		ko:K21901					ko00000,ko03000				Bacteria	1NQRW@1224,1SJSE@1236,3XPP2@561,COG2197@1,COG2197@2	NA|NA|NA	K	May act as a transcriptional regulator of dctA
C1_04134	155864.EDL933_4745	9.4e-106	389.4	Escherichia	slp	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0016020,GO:0019867,GO:0042802		ko:K07285					ko00000				Bacteria	1MZ8C@1224,1S9UB@1236,3XPBG@561,COG3065@1,COG3065@2	NA|NA|NA	M	Outer membrane protein slp
C1_04135	481805.EcolC_0212	8.1e-130	469.9	Gammaproteobacteria													Bacteria	1NS1S@1224,1SKRW@1236,2DU92@1,33PF7@2	NA|NA|NA		
C1_04136	198214.SF3538	3e-163	581.3	Gammaproteobacteria				ko:K07089					ko00000				Bacteria	1MUN8@1224,1RR9N@1236,COG0701@1,COG0701@2	NA|NA|NA	S	permease
C1_04137	393305.YE3478	3.4e-43	180.6	Gammaproteobacteria				ko:K03696,ko:K03892	ko01100,map01100				ko00000,ko03000,ko03110				Bacteria	1MZAU@1224,1S8YH@1236,COG0640@1,COG0640@2	NA|NA|NA	K	transcriptional
C1_04138	198214.SF3536	3.5e-73	280.8	Gammaproteobacteria	arsC	GO:0003674,GO:0003824,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008794,GO:0009987,GO:0016491,GO:0030611,GO:0030613,GO:0030614,GO:0033554,GO:0042221,GO:0046685,GO:0050896,GO:0051716,GO:0055114	1.20.4.1	ko:K00537					ko00000,ko01000			iE2348C_1286.E2348C_3739,iECW_1372.ECW_m3763,iEKO11_1354.EKO11_0239,iLF82_1304.LF82_0152,iNRG857_1313.NRG857_17370,iWFL_1372.ECW_m3763	Bacteria	1MZ4Z@1224,1S3Z8@1236,COG1393@1,COG1393@2	NA|NA|NA	P	arsenate reductase
C1_04139	155864.EDL933_4742	4.7e-230	803.5	Escherichia	arsB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008490,GO:0008509,GO:0015075,GO:0015103,GO:0015104,GO:0015105,GO:0015291,GO:0015318,GO:0015698,GO:0015699,GO:0015700,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042960,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656		ko:K03893					ko00000,ko02000	2.A.45.1,3.A.4.1		iAF1260.b3502,iB21_1397.B21_03304,iBWG_1329.BWG_3192,iECBD_1354.ECBD_0238,iECB_1328.ECB_03351,iECDH10B_1368.ECDH10B_3678,iECDH1ME8569_1439.ECDH1ME8569_3381,iECD_1391.ECD_03351,iECH74115_1262.ECH74115_4851,iECIAI1_1343.ECIAI1_3649,iECO103_1326.ECO103_4229,iECO111_1330.ECO111_4311,iECO26_1355.ECO26_4590,iECSE_1348.ECSE_3768,iECSP_1301.ECSP_4482,iECs_1301.ECs4374,iETEC_1333.ETEC_3749,iEcDH1_1363.EcDH1_0212,iEcE24377_1341.EcE24377A_3985,iEcHS_1320.EcHS_A3704,iEcolC_1368.EcolC_0214,iG2583_1286.G2583_4228,iJO1366.b3502,iSFV_1184.SFV_3514,iSF_1195.SF3535,iS_1188.S4233,iUMNK88_1353.UMNK88_4279,iY75_1357.Y75_RS19690,iZ_1308.Z4904	Bacteria	1MUX4@1224,1RMAV@1236,3XPC3@561,COG1055@1,COG1055@2	NA|NA|NA	U	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C1_04140	316407.85676543	3.7e-60	237.3	Escherichia	arsR	GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0043170,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0046685,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141		ko:K03892,ko:K21903					ko00000,ko03000				Bacteria	1MZT1@1224,1SAI5@1236,3XPX9@561,COG0640@1,COG0640@2	NA|NA|NA	K	Transcriptional repressor for the arsEFG operon. ArsE is a trans-acting regulatory protein which controls its own expression. The repressive effect of ArsE is alleviated by oxyions of III oxidation state of arsenic, antimony, and bismuth, as well as arsenate (As(V)) (By similarity)
C1_04141	362663.ECP_3591	6.9e-20	102.4	Escherichia													Bacteria	1QIQ7@1224,1TGJI@1236,2AV4N@1,31KUV@2,3XR7E@561	NA|NA|NA		
C1_04142	469008.B21_03302	4.5e-263	913.3	Escherichia	gor	GO:0000166,GO:0003674,GO:0003824,GO:0004362,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015036,GO:0015037,GO:0015038,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071949,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748	1.8.1.7	ko:K00383	ko00480,ko04918,map00480,map04918		R00094,R00115	RC00011	ko00000,ko00001,ko01000			iZ_1308.Z4900	Bacteria	1MU2Z@1224,1RMC0@1236,3XNV7@561,COG1249@1,COG1249@2	NA|NA|NA	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1_04143	199310.c4298	2.2e-159	568.2	Escherichia	rlmJ	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008988,GO:0009451,GO:0009987,GO:0010467,GO:0015976,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036307,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.266	ko:K07115					ko00000,ko01000,ko03009				Bacteria	1MWGA@1224,1RNI1@1236,3XMD2@561,COG2961@1,COG2961@2	NA|NA|NA	J	Specifically methylates the adenine in position 2030 of 23S rRNA
C1_04144	469008.B21_03300	0.0	1384.4	Escherichia	prlC	GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006465,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0034641,GO:0034645,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051604,GO:0070011,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564,GO:1901576	3.4.15.5,3.4.24.70	ko:K01284,ko:K01414					ko00000,ko01000,ko01002				Bacteria	1MU1K@1224,1RMAH@1236,3XNTT@561,COG0339@1,COG0339@2	NA|NA|NA	E	May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4)
C1_04145	155864.EDL933_4735	1.9e-138	498.4	Escherichia	rsmJ	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036308,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.242	ko:K15984					ko00000,ko01000,ko03009				Bacteria	1MX8Z@1224,1RMIB@1236,3XMKK@561,COG0742@1,COG0742@2	NA|NA|NA	J	Specifically methylates the guanosine in position 1516 of 16S rRNA
C1_04146	316407.85676548	1.8e-273	948.0	Escherichia	dtpB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006855,GO:0006857,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015238,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015333,GO:0015672,GO:0015833,GO:0015893,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0035442,GO:0035443,GO:0035672,GO:0035673,GO:0042221,GO:0042493,GO:0042886,GO:0042887,GO:0042891,GO:0042895,GO:0042937,GO:0042938,GO:0042939,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071916,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600,GO:1904680		ko:K03305					ko00000	2.A.17		iB21_1397.B21_01594,iBWG_1329.BWG_1449,iEC042_1314.EC042_1803,iECBD_1354.ECBD_2009,iECB_1328.ECB_01604,iECDH10B_1368.ECDH10B_1768,iECDH1ME8569_1439.ECDH1ME8569_1578,iECD_1391.ECD_01604,iECH74115_1262.ECH74115_4843,iECSP_1301.ECSP_4476,iECUMN_1333.ECUMN_1925,iECs_1301.ECs4368,iETEC_1333.ETEC_1669,iEcDH1_1363.EcDH1_2006,iEcSMS35_1347.EcSMS35_1565,iEcolC_1368.EcolC_1995,iJO1366.b1634,iUMNK88_1353.UMNK88_2094,iY75_1357.Y75_RS08570,iZ_1308.Z4896	Bacteria	1MW6W@1224,1RM8P@1236,3XPF2@561,COG3104@1,COG3104@2	NA|NA|NA	U	Proton-dependent permease that transports di- and tripeptides
C1_04147	1114922.CIFAM_12_00790	1.1e-74	285.8	Citrobacter	uspA	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0042802,GO:0044424,GO:0044464		ko:K06149,ko:K14064					ko00000				Bacteria	1MV6Y@1224,1RQQ7@1236,3WV7C@544,COG0589@1,COG0589@2	NA|NA|NA	T	Required for resistance to DNA-damaging agents
C1_04148	1440052.EAKF1_ch2466	1.2e-57	228.8	Escherichia	uspB	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009636,GO:0010033,GO:0016020,GO:0042221,GO:0042493,GO:0044464,GO:0045471,GO:0046677,GO:0050896,GO:0071944,GO:0097305,GO:1901700		ko:K06144					ko00000,ko02000	9.B.4.1.1			Bacteria	1RDHD@1224,1S3P8@1236,291H9@1,2ZP3V@2,3XPS7@561	NA|NA|NA	S	response to ethanol
C1_04149	155864.EDL933_4730	3.4e-272	943.7	Escherichia	pitA	GO:0000041,GO:0003674,GO:0005215,GO:0005315,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006817,GO:0006820,GO:0006829,GO:0008150,GO:0008324,GO:0008509,GO:0015075,GO:0015077,GO:0015078,GO:0015103,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015654,GO:0015672,GO:0015698,GO:0015710,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098656,GO:0098660,GO:0098661,GO:0098662,GO:1902600		ko:K03306,ko:K16322					ko00000,ko02000	2.A.20,2.A.20.1		iECO111_1330.ECO111_4301	Bacteria	1MVXK@1224,1RP0Q@1236,3XMW3@561,COG0306@1,COG0306@2	NA|NA|NA	P	Low-affinity inorganic phosphate transport. Can also transport arsenate
C1_04150	469008.B21_03294	1.8e-231	808.1	Escherichia	yhiN	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K07007					ko00000				Bacteria	1MUGC@1224,1RNCW@1236,3XMPE@561,COG2081@1,COG2081@2	NA|NA|NA	S	HI0933-like protein
C1_04151	155864.EDL933_4727	1.9e-192	678.3	Escherichia	yhiM	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944											Bacteria	1NP1K@1224,1TGB4@1236,28KGD@1,2ZA26@2,3XQBH@561	NA|NA|NA	S	Protein of unknown function (DUF2776)
C1_04152	198214.SF3505	9.6e-192	676.0	Gammaproteobacteria													Bacteria	1NU0X@1224,1SKUI@1236,2F0JS@1,33S2G@2	NA|NA|NA	S	Domain of unknown function (DUF4049)
C1_04153	469008.B21_03292	5.8e-64	250.0	Gammaproteobacteria													Bacteria	1NU0X@1224,1SKUI@1236,2F0JS@1,33S2G@2	NA|NA|NA	S	Domain of unknown function (DUF4049)
C1_04154	316407.85676555	3.2e-308	1063.5	Gammaproteobacteria	yhiJ												Bacteria	1NRVU@1224,1SKWJ@1236,2F0JS@1,33TNG@2	NA|NA|NA	S	Domain of unknown function (DUF4049)
C1_04155	469008.B21_03289	2e-157	562.0	Escherichia	yhiI	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K01993					ko00000				Bacteria	1MUG6@1224,1RS3I@1236,3XP98@561,COG0845@1,COG0845@2	NA|NA|NA	M	protein secretion
C1_04156	316407.85676557	0.0	1769.6	Escherichia	rbbA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006417,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0042623,GO:0043021,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045727,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060187,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1990904,GO:2000112		ko:K01990,ko:K13926		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	1QTT9@1224,1T1GD@1236,3XP1H@561,COG0842@1,COG0842@2,COG1129@1,COG1129@2	NA|NA|NA	V	Exhibits an intrinsic ATPase activity that is stimulated by both 70S ribosomes and 30S ribosomal subunits. Could be involved in protein-chain elongation and in release of deacyl-tRNA from ribosomes after peptide bond synthesis. Stimulates the synthesis of polyphenylalanine in vitro
C1_04157	198214.SF3501	9e-201	706.1	Gammaproteobacteria	yhhJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K01992		M00254			ko00000,ko00002,ko02000	3.A.1			Bacteria	1MUIA@1224,1RQSE@1236,COG0842@1,COG0842@2	NA|NA|NA	V	ABC-type multidrug transport system, permease component
C1_04158	316407.85676559	4.3e-219	766.9	Escherichia	yhhI												Bacteria	1MXB5@1224,1RSAV@1236,3XQUD@561,COG5433@1,COG5433@2	NA|NA|NA	L	transposase
C1_04159	316407.85676449	2.6e-36	157.5	Escherichia	yibA	GO:0006950,GO:0006974,GO:0008150,GO:0009314,GO:0009628,GO:0009987,GO:0033554,GO:0042221,GO:0046677,GO:0050896,GO:0051716											Bacteria	1NB0I@1224,1SV0F@1236,3XR9A@561,COG1413@1,COG1413@2	NA|NA|NA	C	response to radiation
C1_04160	316407.85676560	1.2e-64	252.3	Bacteria	yhhH												Bacteria	2DRW6@1,33DD7@2	NA|NA|NA	S	NTF2 fold immunity protein
C1_04161	316407.85676561	0.0	2424.4	Escherichia	rhsB	GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010438,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042594,GO:0050896,GO:0051716,GO:0071496											Bacteria	1MVV1@1224,1SKYM@1236,3XQSX@561,COG3209@1,COG3209@2	NA|NA|NA	M	Rhs elements have a nonessential function. They may play an important role in the natural ecology of the cell
C1_04162	1440052.EAKF1_ch2473c	1e-69	269.2	Escherichia	nikR	GO:0000976,GO:0000984,GO:0000985,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016043,GO:0016151,GO:0019219,GO:0019222,GO:0022607,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0032991,GO:0032993,GO:0042802,GO:0043167,GO:0043169,GO:0043254,GO:0043565,GO:0043933,GO:0044085,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0060255,GO:0065003,GO:0065007,GO:0071840,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141		ko:K07722					ko00000,ko03000				Bacteria	1RK4R@1224,1S44Q@1236,3XPMA@561,COG0864@1,COG0864@2	NA|NA|NA	K	Transcriptional repressor of the nikABCDE operon. Is active in the presence of excessive concentrations of intracellular nickel
C1_04163	316407.85676563	4.7e-143	513.8	Escherichia	nikE	GO:0000041,GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0006810,GO:0006811,GO:0006812,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0009987,GO:0015675,GO:0017076,GO:0030001,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034220,GO:0035444,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0097159,GO:0097367,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901363	3.6.3.24	ko:K02032,ko:K10824	ko02010,ko02024,map02010,map02024	M00239,M00440			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.5		iAPECO1_1312.APECO1_2974,iE2348C_1286.E2348C_3721,iECABU_c1320.ECABU_c39100,iECED1_1282.ECED1_4153,iECOK1_1307.ECOK1_3909,iECP_1309.ECP_3575,iECS88_1305.ECS88_3883,iUMN146_1321.UM146_17525,iUTI89_1310.UTI89_C3997,ic_1306.c4273	Bacteria	1R3X1@1224,1RMIC@1236,3XM78@561,COG1124@1,COG1124@2	NA|NA|NA	P	Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system
C1_04164	316407.85676564	1.1e-133	482.6	Escherichia	nikD	GO:0000041,GO:0000166,GO:0003674,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008144,GO:0008150,GO:0015232,GO:0015675,GO:0015886,GO:0016020,GO:0017076,GO:0022857,GO:0030001,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034220,GO:0035444,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0097159,GO:0097367,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901363,GO:1901678	3.6.3.24	ko:K02031,ko:K02032,ko:K12371,ko:K15583,ko:K15586,ko:K15587	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00324,M00439,M00440			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25		iECIAI1_1343.ECIAI1_1494,iECIAI39_1322.ECIAI39_3960,iEcSMS35_1347.EcSMS35_3763,iSBO_1134.SBO_1821	Bacteria	1R4F4@1224,1RZNK@1236,3XPEJ@561,COG0444@1,COG0444@2	NA|NA|NA	P	Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system
C1_04165	155864.EDL933_4709	5.3e-150	537.0	Escherichia	nikC	GO:0000041,GO:0003674,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015099,GO:0015318,GO:0015675,GO:0016020,GO:0016021,GO:0016151,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0035444,GO:0043167,GO:0043169,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0046914,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098655,GO:0098660,GO:0098662	3.6.3.24	ko:K02034,ko:K12370,ko:K13891,ko:K15582,ko:K15586,ko:K15587	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00324,M00348,M00439,M00440			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.11,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25		iAF1260.b1245,iAF1260.b3542,iAPECO1_1312.APECO1_2906,iB21_1397.B21_01229,iB21_1397.B21_03344,iBWG_1329.BWG_3231,iE2348C_1286.E2348C_3790,iEC042_1314.EC042_3848,iEC55989_1330.EC55989_1342,iEC55989_1330.EC55989_3993,iECABU_c1320.ECABU_c08730,iECABU_c1320.ECABU_c39840,iECBD_1354.ECBD_0194,iECBD_1354.ECBD_2377,iECB_1328.ECB_01219,iECB_1328.ECB_03393,iECDH10B_1368.ECDH10B_1307,iECDH10B_1368.ECDH10B_3721,iECDH1ME8569_1439.ECDH1ME8569_1185,iECDH1ME8569_1439.ECDH1ME8569_3422,iECD_1391.ECD_01219,iECD_1391.ECD_03393,iECED1_1282.ECED1_4221,iECH74115_1262.ECH74115_4910,iECIAI1_1343.ECIAI1_1264,iECIAI1_1343.ECIAI1_3700,iECIAI39_1322.ECIAI39_4051,iECNA114_1301.ECNA114_3693,iECO103_1326.ECO103_1345,iECO103_1326.ECO103_4274,iECO111_1330.ECO111_1572,iECO111_1330.ECO111_4358,iECO26_1355.ECO26_1756,iECO26_1355.ECO26_4636,iECOK1_1307.ECOK1_3988,iECP_1309.ECP_0846,iECP_1309.ECP_3643,iECS88_1305.ECS88_3962,iECSE_1348.ECSE_1293,iECSE_1348.ECSE_3815,iECSF_1327.ECSF_3376,iECSP_1301.ECSP_1637,iECSP_1301.ECSP_4533,iECUMN_1333.ECUMN_1542,iECUMN_1333.ECUMN_4052,iECW_1372.ECW_m1337,iECW_1372.ECW_m3808,iECs_1301.ECs1745,iECs_1301.ECs4422,iEKO11_1354.EKO11_0191,iEKO11_1354.EKO11_2607,iETEC_1333.ETEC_1347,iETEC_1333.ETEC_3787,iEcDH1_1363.EcDH1_0170,iEcDH1_1363.EcDH1_2403,iEcE24377_1341.EcE24377A_1393,iEcE24377_1341.EcE24377A_4034,iEcHS_1320.EcHS_A1354,iEcHS_1320.EcHS_A3741,iEcSMS35_1347.EcSMS35_3861,iEcolC_1368.EcolC_0173,iEcolC_1368.EcolC_2383,iG2583_1286.G2583_1517,iG2583_1286.G2583_4279,iJO1366.b1245,iJO1366.b3542,iLF82_1304.LF82_0517,iNRG857_1313.NRG857_17605,iSSON_1240.SSON_1935,iSbBS512_1146.SbBS512_E3843,iUMN146_1321.UM146_17880,iUMNK88_1353.UMNK88_1565,iUMNK88_1353.UMNK88_4323,iUTI89_1310.UTI89_C4080,iWFL_1372.ECW_m1337,iWFL_1372.ECW_m3808,iY75_1357.Y75_RS06515,iY75_1357.Y75_RS19465,iYL1228.KPN_03852,iZ_1308.Z2021,iZ_1308.Z4959,ic_1306.c0917,ic_1306.c4357	Bacteria	1NNQQ@1224,1RNGP@1236,3XNXB@561,COG1173@1,COG1173@2	NA|NA|NA	P	Nickel transport system permease protein nikC
C1_04166	316407.85676566	1.9e-172	611.7	Escherichia	nikB	GO:0000041,GO:0003674,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015099,GO:0015318,GO:0015675,GO:0016020,GO:0016021,GO:0016151,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0035444,GO:0043167,GO:0043169,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0046914,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098655,GO:0098660,GO:0098662		ko:K15585	ko02010,map02010	M00440			ko00000,ko00001,ko00002,ko02000	3.A.1.5		iG2583_1286.G2583_4198	Bacteria	1MU8Z@1224,1RP7R@1236,3XMHP@561,COG0601@1,COG0601@2	NA|NA|NA	P	Nickel transport system permease protein NikB
C1_04167	316407.85676567	2.1e-304	1050.8	Escherichia	nikA	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006935,GO:0008150,GO:0009605,GO:0016151,GO:0020037,GO:0030288,GO:0030313,GO:0031975,GO:0040011,GO:0042221,GO:0042330,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050896,GO:0050919,GO:0051540,GO:0097159,GO:1901363		ko:K15584	ko02010,map02010	M00440			ko00000,ko00001,ko00002,ko02000	3.A.1.5		iSFV_1184.SFV_3479	Bacteria	1P1HT@1224,1RQ7Z@1236,3XPAH@561,COG0747@1,COG0747@2	NA|NA|NA	E	periplasmic
C1_04168	316407.85676568	1.3e-110	405.6	Escherichia	sfp	GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006520,GO:0006553,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008652,GO:0008897,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016780,GO:0018070,GO:0018193,GO:0018209,GO:0018215,GO:0019538,GO:0019752,GO:0019878,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.8.7	ko:K00997,ko:K06133	ko00770,map00770		R01625	RC00002	ko00000,ko00001,ko01000			iECNA114_1301.ECNA114_3584	Bacteria	1MZHC@1224,1SCGA@1236,3XNTQ@561,COG2091@1,COG2091@2	NA|NA|NA	H	May be involved in an alternative pathway for phosphopantetheinyl transfer and holo-ACP synthesis in E.coli. The native apo-protein substrate is
C1_04169	155864.EDL933_4687	3.9e-182	644.0	Escherichia	yhhT	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944		ko:K03548,ko:K11744					ko00000,ko02000	2.A.86.1			Bacteria	1MXXU@1224,1RQCM@1236,3XP7B@561,COG0628@1,COG0628@2	NA|NA|NA	S	transporter activity
C1_04170	198214.SF3491	5.1e-229	800.0	Gammaproteobacteria	yhhS	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1QUBP@1224,1RUKT@1236,COG0477@1,COG0477@2	NA|NA|NA	EGP	MFS-type transporter
C1_04171	155864.EDL933_4685	5.1e-96	357.1	Escherichia	dcrB	GO:0005575,GO:0005623,GO:0042597,GO:0044464											Bacteria	1MVXI@1224,1RSF1@1236,28J7P@1,2Z932@2,3XN32@561	NA|NA|NA	S	DcrB
C1_04172	155864.EDL933_4684	2.8e-117	427.9	Escherichia	yhhQ	GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006810,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046116,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0072531,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659,GO:1990397		ko:K09125					ko00000				Bacteria	1MVQU@1224,1RNX0@1236,3XN77@561,COG1738@1,COG1738@2	NA|NA|NA	U	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C1_04173	155864.EDL933_4683	2.3e-40	171.0	Escherichia	tusA	GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0019725,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042592,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048878,GO:0051186,GO:0051188,GO:0051189,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0090407,GO:0097163,GO:0140104,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576		ko:K04085	ko04122,map04122				ko00000,ko00001,ko01000,ko03016				Bacteria	1MZA5@1224,1S8TC@1236,3XPXD@561,COG0425@1,COG0425@2	NA|NA|NA	J	Sulfur carrier protein involved in sulfur trafficking in the cell. Part of a sulfur-relay system required for 2-thiolation during synthesis of 2-thiouridine of the modified wobble base 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) in tRNA. Interacts with IscS and stimulates its cysteine desulfurase activity. Accepts an activated sulfur from IscS, which is then transferred to TusD, and thus determines the direction of sulfur flow from IscS to 2-thiouridine formation. Also appears to be involved in sulfur transfer for the biosynthesis of molybdopterin
C1_04174	155864.EDL933_4682	0.0	1343.6	Escherichia	zntA	GO:0000041,GO:0003674,GO:0003824,GO:0005215,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0006829,GO:0006950,GO:0008150,GO:0008324,GO:0008551,GO:0009636,GO:0010035,GO:0010038,GO:0010043,GO:0010312,GO:0015075,GO:0015086,GO:0015087,GO:0015094,GO:0015099,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015675,GO:0015691,GO:0015692,GO:0016020,GO:0016021,GO:0016462,GO:0016463,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0034220,GO:0035444,GO:0042221,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0044464,GO:0046686,GO:0046873,GO:0046915,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070574,GO:0070838,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0090662,GO:0097501,GO:0098655,GO:0098660,GO:0098662,GO:0098754,GO:0099131,GO:0099132,GO:1990359	3.6.3.3,3.6.3.5	ko:K01534					ko00000,ko01000	3.A.3.6		iLF82_1304.LF82_3723,iNRG857_1313.NRG857_17200,iUMNK88_1353.UMNK88_4239,iYL1228.KPN_03835	Bacteria	1MU08@1224,1RN2C@1236,3XM67@561,COG2217@1,COG2217@2	NA|NA|NA	P	Confers resistance to zinc, cadmium and lead. Couples the hydrolysis of ATP with the export of zinc, cadmium or lead, with highest activity when the metals are present as metal-thiolate complexes. Can also bind nickel, copper, cobalt and mercury
C1_04175	198214.SF3486	1.1e-112	412.5	Gammaproteobacteria	yhhN	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1PN0I@1224,1RNUV@1236,COG3714@1,COG3714@2	NA|NA|NA	S	membrane
C1_04176	198214.SF3485	1.1e-56	225.7	Gammaproteobacteria	yhhM												Bacteria	1RDRA@1224,1S5XK@1236,2AHZY@1,318D9@2	NA|NA|NA	S	Protein of unknown function (DUF2500)
C1_04177	155864.EDL933_4679	1.7e-41	174.9	Escherichia	yhhL			ko:K08993					ko00000				Bacteria	1N00W@1224,1SA2V@1236,3XPWX@561,COG3776@1,COG3776@2	NA|NA|NA	S	Protein of unknown function (DUF1145)
C1_04178	199310.c4258	5.6e-109	400.2	Escherichia	rsmD	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052913,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.171	ko:K08316			R07234	RC00003	ko00000,ko01000,ko03009				Bacteria	1MXKW@1224,1RN21@1236,3XNX4@561,COG0742@1,COG0742@2	NA|NA|NA	J	Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle
C1_04179	469008.B21_03266	2.7e-229	801.2	Escherichia	ftsY	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019897,GO:0019898,GO:0031224,GO:0031226,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033036,GO:0033365,GO:0034613,GO:0035639,GO:0036094,GO:0042886,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7			Bacteria	1MUDU@1224,1RNIN@1236,3XN2M@561,COG0552@1,COG0552@2	NA|NA|NA	D	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components
C1_04180	155864.EDL933_4676	9.9e-123	446.0	Escherichia	ftsE	GO:0000166,GO:0000287,GO:0000910,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0007049,GO:0008144,GO:0008150,GO:0008356,GO:0009898,GO:0009966,GO:0009987,GO:0010646,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019897,GO:0019898,GO:0022402,GO:0022603,GO:0022607,GO:0023051,GO:0030145,GO:0030554,GO:0031234,GO:0032153,GO:0032506,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042173,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043937,GO:0043938,GO:0044085,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0046677,GO:0046872,GO:0046914,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051094,GO:0051301,GO:0065007,GO:0070297,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363,GO:1902531		ko:K09811,ko:K09812	ko02010,map02010	M00256			ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140			Bacteria	1MVQ4@1224,1RMZA@1236,3XP97@561,COG2884@1,COG2884@2	NA|NA|NA	D	Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring
C1_04181	198214.SF3480	2.7e-191	674.5	Gammaproteobacteria	ftsX	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009274,GO:0009276,GO:0009987,GO:0016020,GO:0016021,GO:0030312,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0032153,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0071944		ko:K09811,ko:K09812	ko02010,map02010	M00256			ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140			Bacteria	1MU65@1224,1RYBV@1236,COG2177@1,COG2177@2	NA|NA|NA	D	Part of the ABC transporter FtsEX involved in cellular division
C1_04182	1440052.EAKF1_ch2494	1.3e-154	552.4	Escherichia	rpoH	GO:0000150,GO:0000976,GO:0000984,GO:0000985,GO:0000988,GO:0000990,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006310,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009009,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031421,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140097,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2001141		ko:K03089					ko00000,ko03021				Bacteria	1MVWR@1224,1RMFR@1236,3XM8B@561,COG0568@1,COG0568@2	NA|NA|NA	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes
C1_04183	1440052.EAKF1_ch2502	2.6e-205	721.1	Escherichia	livJ	GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0008150,GO:0015711,GO:0015803,GO:0015804,GO:0015818,GO:0015820,GO:0015829,GO:0015849,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0046942,GO:0051179,GO:0051234,GO:0071702,GO:0071705		ko:K01999	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4		iECNA114_1301.ECNA114_3569,iECSF_1327.ECSF_3279,iECs_1301.ECs4309,iEcSMS35_1347.EcSMS35_3743,iG2583_1286.G2583_4163,iSFxv_1172.SFxv_3794,iSSON_1240.SSON_3698,iS_1188.S4285,iZ_1308.Z4834	Bacteria	1MWJ1@1224,1RP5V@1236,3XMH3@561,COG0683@1,COG0683@2	NA|NA|NA	E	This protein is a component of the leucine, isoleucine, valine, (threonine) transport system, which is one of the two periplasmic binding protein-dependent transport systems of the high-affinity transport of the branched-chain amino acids
C1_04184	155864.EDL933_4672	2.1e-39	167.9	Escherichia													Bacteria	1N13V@1224,1S955@1236,3XQ0W@561,COG4453@1,COG4453@2	NA|NA|NA	S	Protein of unknown function (DUF1778)
C1_04185	155864.EDL933_4671	2.9e-93	347.8	Escherichia	Z012_05445		2.3.1.189	ko:K15520					ko00000,ko01000				Bacteria	1N009@1224,1S2EE@1236,3XN46@561,COG0454@1,COG0456@2	NA|NA|NA	K	Acetyltransferase (GNAT) domain
C1_04186	198214.SF3477	2.2e-66	258.1	Gammaproteobacteria	panZ	GO:0006082,GO:0006508,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0010467,GO:0015939,GO:0015940,GO:0016053,GO:0016485,GO:0019538,GO:0019752,GO:0031638,GO:0032787,GO:0034641,GO:0042364,GO:0042398,GO:0043086,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0050790,GO:0051186,GO:0051188,GO:0051604,GO:0065007,GO:0065009,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576											Bacteria	1RIN3@1224,1S494@1236,COG0454@1,COG0456@2	NA|NA|NA	K	Controls both the activation and catalytic activity of PanD in a coenzyme A (CoA)-dependent fashion
C1_04187	316407.85676585	5.7e-208	729.9	Escherichia	livK	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0008150,GO:0015711,GO:0015803,GO:0015804,GO:0015818,GO:0015820,GO:0015829,GO:0015849,GO:0016597,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044464,GO:0046942,GO:0051179,GO:0051234,GO:0070728,GO:0071702,GO:0071705		ko:K01999	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4		iECNA114_1301.ECNA114_3569,iECSF_1327.ECSF_3279,iEcSMS35_1347.EcSMS35_3743,iUTI89_1310.UTI89_C3965,iYL1228.KPN_03820	Bacteria	1MWJ1@1224,1RP5V@1236,3XP89@561,COG0683@1,COG0683@2	NA|NA|NA	E	This protein is a component of the leucine-specific transport system, which is one of the two periplasmic binding protein-dependent transport systems of the high-affinity transport of the branched-chain amino acids in E.coli
C1_04188	1440052.EAKF1_ch2506	1.2e-158	565.8	Escherichia	livH	GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015190,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015820,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0043090,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098713,GO:0098739,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039		ko:K01997	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4		iSFV_1184.SFV_3460,iSF_1195.SF3475,iSFxv_1172.SFxv_3791,iS_1188.S4288	Bacteria	1MU25@1224,1RNDV@1236,3XMWM@561,COG0559@1,COG0559@2	NA|NA|NA	E	Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane
C1_04189	155864.EDL933_4666	7.5e-228	796.2	Escherichia	livM	GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039		ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4		iPC815.YPO3806,iSDY_1059.SDY_3605	Bacteria	1MV66@1224,1RPTT@1236,3XMKJ@561,COG4177@1,COG4177@2	NA|NA|NA	P	the binding-protein-dependent transport system
C1_04190	155864.EDL933_4665	2.1e-140	505.0	Escherichia	livG	GO:0000166,GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005488,GO:0005524,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008144,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0017076,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034220,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0097159,GO:0097367,GO:0098655,GO:0098656,GO:1901265,GO:1901363,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039		ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4		iECNA114_1301.ECNA114_3561	Bacteria	1MUTY@1224,1RQU2@1236,3XMRQ@561,COG0411@1,COG0411@2	NA|NA|NA	P	High-affinity branched-chain amino acid transport ATP-binding protein livG
C1_04191	155864.EDL933_4664	1.6e-126	458.8	Escherichia	livF	GO:0000166,GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005488,GO:0005524,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008144,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015175,GO:0015179,GO:0015188,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0017076,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034220,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0097159,GO:0097367,GO:0098655,GO:0098656,GO:1901265,GO:1901363,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039		ko:K01996	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4		iAPECO1_1312.APECO1_3005,iECs_1301.ECs4301,iSSON_1240.SSON_3692,iUTI89_1310.UTI89_C3961,iYL1228.KPN_03816,iZ_1308.Z4824	Bacteria	1MVVC@1224,1RMK8@1236,3XNKA@561,COG0410@1,COG0410@2	NA|NA|NA	P	High-affinity branched-chain amino acid transport ATP-binding protein
C1_04192	155864.EDL933_4660	3.6e-257	893.6	Escherichia	ugpB	GO:0001407,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0015711,GO:0015748,GO:0015794,GO:0030288,GO:0030313,GO:0031975,GO:0034220,GO:0042597,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0098656,GO:1901264		ko:K02027,ko:K05813	ko02010,map02010	M00198,M00207			ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.3		iEcE24377_1341.EcE24377A_3931	Bacteria	1MVMW@1224,1RRH3@1236,3XMXF@561,COG1653@1,COG1653@2	NA|NA|NA	P	Sn-glycerol-3-phosphate and glycerophosphoryl diester- binding protein interacts with the binding protein-dependent transport system UgpACE
C1_04193	1440052.EAKF1_ch2513	1.7e-157	562.0	Escherichia	ugpA	GO:0001406,GO:0001407,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015169,GO:0015605,GO:0015711,GO:0015748,GO:0015794,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0032991,GO:0034220,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055052,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098656,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351		ko:K05814,ko:K10109,ko:K15771	ko02010,map02010	M00194,M00198,M00491			ko00000,ko00001,ko00002,ko02000	3.A.1.1.1,3.A.1.1.16,3.A.1.1.2,3.A.1.1.22,3.A.1.1.3		iSFxv_1172.SFxv_3786	Bacteria	1MVAP@1224,1RNQF@1236,3XM4S@561,COG1175@1,COG1175@2	NA|NA|NA	G	probably responsible for the translocation of the substrate across the membrane
C1_04194	469008.B21_03253	2.2e-151	541.6	Escherichia	ugpE	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015169,GO:0015605,GO:0015711,GO:0015748,GO:0015794,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0032991,GO:0034220,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055052,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098656,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351		ko:K05815	ko02010,map02010	M00198			ko00000,ko00001,ko00002,ko02000	3.A.1.1.3		iLF82_1304.LF82_2362,iNRG857_1313.NRG857_17110,iYL1228.KPN_03811	Bacteria	1MUWS@1224,1RMKG@1236,3XNKK@561,COG0395@1,COG0395@2	NA|NA|NA	G	probably responsible for the translocation of the substrate across the membrane
C1_04195	481805.EcolC_0266	3.3e-200	704.1	Escherichia	ugpC	GO:0000166,GO:0001406,GO:0001407,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008144,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015169,GO:0015399,GO:0015405,GO:0015430,GO:0015605,GO:0015711,GO:0015748,GO:0015794,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0031224,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055052,GO:0055085,GO:0071702,GO:0071944,GO:0097159,GO:0097367,GO:0098533,GO:0098656,GO:0098796,GO:0098797,GO:1901264,GO:1901265,GO:1901363,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351	3.6.3.20	ko:K05816,ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00198,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1,3.A.1.1.3		iAF1260.b3450,iB21_1397.B21_03252,iBWG_1329.BWG_3141,iECABU_c1320.ECABU_c38800,iECB_1328.ECB_03299,iECDH10B_1368.ECDH10B_3624,iECD_1391.ECD_03299,iETEC_1333.ETEC_3696,iJO1366.b3450,iJR904.b3450,iUMNK88_1353.UMNK88_4218,iY75_1357.Y75_RS19980,ic_1306.c4239	Bacteria	1MU3I@1224,1RM9E@1236,3XPDF@561,COG3842@1,COG3842@2	NA|NA|NA	P	Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system
C1_04196	469008.B21_03251	9e-141	506.1	Escherichia	ugpQ	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0008081,GO:0008889,GO:0016787,GO:0016788,GO:0042578,GO:0043167,GO:0043169,GO:0046872,GO:0047389,GO:0047395	3.1.4.46	ko:K01126	ko00564,map00564		R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000			iEC042_1314.EC042_3710,iEC55989_1330.EC55989_3857	Bacteria	1MU8H@1224,1RQWX@1236,3XNM9@561,COG0584@1,COG0584@2	NA|NA|NA	C	glycerophosphoryl diester phosphodiesterase
C1_04197	198214.SF3465	3.2e-69	267.7	Gammaproteobacteria	yhhA												Bacteria	1N0WI@1224,1SAJI@1236,2D4KK@1,32THA@2	NA|NA|NA	S	Protein of unknown function (DUF2756)
C1_04198	481805.EcolC_0269	0.0	1146.3	Escherichia	ggt	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006082,GO:0006508,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0019538,GO:0019752,GO:0030288,GO:0030313,GO:0031975,GO:0034722,GO:0036374,GO:0042597,GO:0043094,GO:0043102,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070011,GO:0071704,GO:0097264,GO:0140096,GO:1901564,GO:1901566,GO:1901576	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100		R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002			iAPECO1_1312.APECO1_3012,iECOK1_1307.ECOK1_3869,iECS88_1305.ECS88_3844,iECW_1372.ECW_m3706,iEKO11_1354.EKO11_0296,iETEC_1333.ETEC_3693,iUMN146_1321.UM146_17325,iUTI89_1310.UTI89_C3954,iWFL_1372.ECW_m3706	Bacteria	1MUV6@1224,1RMIT@1236,3XN4W@561,COG0405@1,COG0405@2	NA|NA|NA	M	it may function in amino acid uptake salvage, or possibly in peptidoglycan linkage. Catalyzes the hydrolysis and transpeptidation of many gamma-glutamyl compounds (including some D-gamma-glutamyl substrates), with a preference for basic and aromatic amino acids as acceptors. The KM values for gamma-glutamyl acceptors are so high that it has been proposed transpeptidation is not the physiological role in E.coli
C1_04199	316407.85676597	5.3e-49	199.9	Gammaproteobacteria	yrhB												Bacteria	1N6EH@1224,1SBUZ@1236,2EHFB@1,32TBX@2	NA|NA|NA	S	Immunity protein 35
C1_04201	469008.B21_03247	2.5e-86	324.7	Escherichia	yrhA												Bacteria	1RFEN@1224,1S549@1236,292QA@1,2ZQ83@2,3XRD0@561	NA|NA|NA		
C1_04202	316407.85676601	2e-222	778.1	Escherichia	yhhZ			ko:K06887					ko00000				Bacteria	1RB0U@1224,1S2CP@1236,3XR91@561,COG3157@1,COG3157@2	NA|NA|NA	S	Type VI secretion system effector, Hcp
C1_04203	316407.85676602	4.8e-90	337.0	Escherichia	yhhY	GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031248,GO:0031365,GO:0032991,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564,GO:1902493,GO:1902494,GO:1990234	2.1.2.9	ko:K00604,ko:K03825	ko00670,ko00970,map00670,map00970		R03940	RC00026,RC00165	ko00000,ko00001,ko01000				Bacteria	1QUGY@1224,1T1YJ@1236,3XP7U@561,COG1247@1,COG1247@2	NA|NA|NA	M	Catalyzes the N-acetylation of L-phenylalanine and L- methionine using acetyl-CoA as acetyl donor in vitro. Cannot accept L-tyrosine as substrate and propionyl-CoA, succinyl-CoA or (S)-methylmalonyl-CoA as acyl donors. Is also able to acetylate and thus detoxify several nonhydrolyzable aminoacyl adenylates, but not the processed form of the peptide- nucleotide antibiotic microcin C (McC). When overproduced, provides complete resistance to leucyl sulfamoyl adenylate (LSA) and partial resistance to alanyl sulfamoyl adenylate (ASA) and phenylalanyl sulfamoyl adenylate (FSA). Therefore, may protect bacteria from various toxic aminoacyl nucleotides, either exogenous or those generated inside the cell during normal metabolism
C1_04204	316407.85676603	1.7e-198	698.4	Escherichia	yhhX	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	1.1.1.371	ko:K16044	ko00562,ko01120,map00562,map01120		R09954	RC00182	ko00000,ko00001,ko01000				Bacteria	1NHXV@1224,1RZPJ@1236,3XN06@561,COG0673@1,COG0673@2	NA|NA|NA	S	oxidoreductase activity
C1_04205	316407.85676604	2.2e-133	481.5	Escherichia	yhhW	GO:0003674,GO:0003824,GO:0008127,GO:0008150,GO:0008152,GO:0016491,GO:0016701,GO:0016702,GO:0051213,GO:0055114		ko:K06911					ko00000				Bacteria	1MVSW@1224,1RNVS@1236,3XMG6@561,COG1741@1,COG1741@2	NA|NA|NA	S	however, may provide a mechanism that would avoid inhibition of key cellular proteins, such as DNA gyrase, by quercetin
C1_04206	155864.EDL933_4648	5.7e-183	646.7	Escherichia	gntR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141		ko:K06145					ko00000,ko03000				Bacteria	1MUEP@1224,1RQKH@1236,3XNR3@561,COG1609@1,COG1609@2	NA|NA|NA	K	Negative regulator for the gluconate utilization system GNT-I, the gntUKR operon
C1_04207	316407.85676606	2.6e-94	351.3	Escherichia	gntK	GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019520,GO:0019521,GO:0019523,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046183,GO:0046316,GO:0046395,GO:0071704,GO:0072329,GO:1901575	2.7.1.12	ko:K00851	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200		R01737	RC00002,RC00017	ko00000,ko00001,ko01000			iECSF_1327.ECSF_4156,iUTI89_1310.UTI89_C3945,iYL1228.KPN_03801	Bacteria	1RHD0@1224,1RP41@1236,3XN1N@561,COG3265@1,COG3265@2	NA|NA|NA	F	gluconokinase activity
C1_04208	155864.EDL933_4646	1.1e-240	839.0	Escherichia	gntU	GO:0003674,GO:0005215,GO:0005402,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0008643,GO:0015075,GO:0015144,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034219,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098655		ko:K03299,ko:K06156					ko00000,ko02000	2.A.8,2.A.8.1.8		iAF1260.b4476,iB21_1397.B21_03240,iBWG_1329.BWG_3127,iEC55989_1330.EC55989_3845,iECB_1328.ECB_03287,iECDH10B_1368.ECDH10B_3609,iECDH1ME8569_1439.ECDH1ME8569_3313,iECD_1391.ECD_03287,iECH74115_1262.ECH74115_4752,iECIAI1_1343.ECIAI1_3581,iECIAI39_1322.ECIAI39_3918,iECO26_1355.ECO26_4525,iECSE_1348.ECSE_3704,iECSP_1301.ECSP_4391,iECUMN_1333.ECUMN_3899,iECs_1301.ECs4285,iEKO11_1354.EKO11_0306,iETEC_1333.ETEC_3684,iEcDH1_1363.EcDH1_0279,iEcE24377_1341.EcE24377A_3914,iEcHS_1320.EcHS_A3635,iEcSMS35_1347.EcSMS35_3719,iEcolC_1368.EcolC_0277,iG2583_1286.G2583_4138,iJO1366.b4476,iSDY_1059.SDY_3587,iUMNK88_1353.UMNK88_4205,iY75_1357.Y75_RS20045,iYL1228.KPN_03800,iZ_1308.Z4804	Bacteria	1MUFG@1224,1RNGE@1236,3XMJC@561,COG2610@1,COG2610@2	NA|NA|NA	P	Low-affinity gluconate
C1_04209	155864.EDL933_4640	3.2e-96	357.8	Escherichia	yhgN	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K05595					ko00000,ko02000	2.A.95.1			Bacteria	1N689@1224,1RPV0@1236,3XMAM@561,COG2095@1,COG2095@2	NA|NA|NA	U	MarC family integral membrane protein
C1_04210	155864.EDL933_4639	1.1e-211	742.3	Escherichia	asd	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004073,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006553,GO:0006555,GO:0006566,GO:0006790,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009081,GO:0009082,GO:0009085,GO:0009086,GO:0009088,GO:0009089,GO:0009090,GO:0009092,GO:0009097,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0033554,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000			iECP_1309.ECP_3527	Bacteria	1MUHG@1224,1RMN3@1236,3XMDB@561,COG0136@1,COG0136@2	NA|NA|NA	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C1_04211	316407.85676610	0.0	1548.9	Escherichia	glgB	GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033554,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:1901576	2.4.1.18	ko:K00700,ko:K17734	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110		ko00000,ko00001,ko00002,ko01000,ko01002,ko04147		CBM48,GH13	iAPECO1_1312.APECO1_3025,iECNA114_1301.ECNA114_3542,iECOK1_1307.ECOK1_3857,iECS88_1305.ECS88_3830,iECSF_1327.ECSF_3253,iLF82_1304.LF82_0837,iNRG857_1313.NRG857_17030,iUTI89_1310.UTI89_C3941	Bacteria	1QTVN@1224,1RQSK@1236,3XMP5@561,COG0296@1,COG0296@2	NA|NA|NA	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C1_04212	316407.85676611	0.0	1404.8	Escherichia	glgX	GO:0000272,GO:0003674,GO:0003824,GO:0004133,GO:0004135,GO:0004553,GO:0005975,GO:0005976,GO:0005977,GO:0005980,GO:0006073,GO:0006091,GO:0006112,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0015926,GO:0015980,GO:0016052,GO:0016787,GO:0016798,GO:0033554,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0090599,GO:1901575	3.2.1.196,3.2.1.68	ko:K01214,ko:K02438	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02111,R09995,R11261		ko00000,ko00001,ko00002,ko01000		CBM48,GH13	iEcHS_1320.EcHS_A3631,iEcolC_1368.EcolC_0281	Bacteria	1MU19@1224,1RP6F@1236,3XNET@561,COG1523@1,COG1523@2	NA|NA|NA	G	Removes maltotriose and maltotetraose chains that are attached by 1,6-alpha-linkage to the limit dextrin main chain, generating a debranched limit dextrin
C1_04213	155864.EDL933_4636	7.6e-252	875.9	Escherichia	glgC	GO:0000166,GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008144,GO:0008150,GO:0008152,GO:0008878,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016043,GO:0016051,GO:0016208,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0022607,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0033692,GO:0034637,GO:0034645,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043933,GO:0044042,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0046872,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0070566,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901576	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_3027,iUTI89_1310.UTI89_C3939,iYL1228.KPN_03796	Bacteria	1MVTC@1224,1RP04@1236,3XP6K@561,COG0448@1,COG0448@2	NA|NA|NA	F	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C1_04214	155864.EDL933_4635	4.7e-279	966.5	Escherichia	glgA	GO:0000271,GO:0003674,GO:0003824,GO:0004373,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008194,GO:0009011,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033554,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046527,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:1901576	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003		GT5	iSFV_1184.SFV_3438	Bacteria	1MUGM@1224,1RNMP@1236,3XP2P@561,COG0297@1,COG0297@2	NA|NA|NA	F	Synthesizes alpha-1,4-glucan chains using ADP-glucose
C1_04215	198214.SF3451	0.0	1647.1	Gammaproteobacteria	glgP	GO:0000272,GO:0003674,GO:0003824,GO:0004645,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0005977,GO:0005980,GO:0006073,GO:0006091,GO:0006112,GO:0008144,GO:0008150,GO:0008152,GO:0008184,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0015980,GO:0016052,GO:0016740,GO:0016757,GO:0016758,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901575	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931		R02111		ko00000,ko00001,ko01000		GT35	iECNA114_1301.ECNA114_3525	Bacteria	1MW4J@1224,1RN8P@1236,COG0058@1,COG0058@2	NA|NA|NA	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
C1_04216	469008.B21_03232	2.5e-275	954.1	Escherichia	sphX			ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222			ko00000,ko00001,ko00002,ko02000	3.A.1.7			Bacteria	1QIED@1224,1TG8R@1236,3XQ3C@561,COG0226@1,COG0226@2	NA|NA|NA	P	Part of the ABC transporter complex PstSACB involved in phosphate import
C1_04218	199310.c4205	3.5e-132	477.6	Proteobacteria													Bacteria	1N92A@1224,2C0A3@1,32Y9P@2	NA|NA|NA		
C1_04219	1440052.EAKF1_ch2536	4.5e-74	284.3	Escherichia													Bacteria	1QIH9@1224,1TGBV@1236,2AUY4@1,31KMK@2,3XQFN@561	NA|NA|NA		
C1_04220	469008.B21_03229	3.2e-294	1016.9	Escherichia	glpD	GO:0000166,GO:0003674,GO:0003824,GO:0004368,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005887,GO:0006072,GO:0006091,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009331,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016614,GO:0016901,GO:0019637,GO:0022900,GO:0031224,GO:0031226,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046168,GO:0046434,GO:0048037,GO:0050660,GO:0050662,GO:0052590,GO:0052646,GO:0055114,GO:0071704,GO:0071944,GO:0071949,GO:0097159,GO:1901135,GO:1901136,GO:1901265,GO:1901363,GO:1901575,GO:1902494,GO:1990204	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110		R00848	RC00029	ko00000,ko00001,ko01000			iSSON_1240.SSON_3663	Bacteria	1MUMY@1224,1RMGP@1236,3XMEJ@561,COG0578@1,COG0578@2	NA|NA|NA	C	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C1_04221	198214.SF3447	7.9e-57	226.1	Gammaproteobacteria	glpE	GO:0003674,GO:0003824,GO:0004792,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016740,GO:0016782,GO:0016783,GO:0044424,GO:0044464	2.8.1.1	ko:K02439,ko:K07390	ko00920,ko01110,ko01120,map00920,map01110,map01120		R01931		ko00000,ko00001,ko01000,ko03029,ko03110			iECSF_1327.ECSF_3244	Bacteria	1MZPW@1224,1S94C@1236,COG0607@1,COG0607@2	NA|NA|NA	P	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide
C1_04222	199310.c4201	6.9e-158	563.1	Escherichia	glpG	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019219,GO:0019222,GO:0019538,GO:0031224,GO:0031226,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042802,GO:0043170,GO:0043565,GO:0044212,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:0140096,GO:1901363,GO:1901564,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K02441					ko00000				Bacteria	1MYPM@1224,1RN1K@1236,3XMTF@561,COG0705@1,COG0705@2	NA|NA|NA	S	Rhomboid-type serine protease that catalyzes intramembrane proteolysis
C1_04223	198214.SF3445	3.3e-138	497.7	Gammaproteobacteria	glpR	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K02444					ko00000,ko03000				Bacteria	1MUJG@1224,1RPS0@1236,COG1349@1,COG1349@2	NA|NA|NA	K	transcriptional regulator
C1_04224	316407.85676620	3.7e-301	1040.0	Escherichia	rtcR	GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141		ko:K14414					ko00000,ko03000				Bacteria	1MX6U@1224,1RS3H@1236,3XNMV@561,COG4650@1,COG4650@2	NA|NA|NA	K	Transcriptional regulatory protein RtcR
C1_04225	316407.85676621	1.1e-233	815.5	Escherichia	rtcB	GO:0003674,GO:0003824,GO:0003909,GO:0005488,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006396,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008452,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0030145,GO:0033554,GO:0034641,GO:0042245,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:0140098,GO:1901360	6.5.1.3	ko:K14415					ko00000,ko01000,ko03016				Bacteria	1MUHA@1224,1RMXH@1236,3XMBB@561,COG1690@1,COG1690@2	NA|NA|NA	S	RNA ligase that mediates the joining of broken tRNA-like stem-loop structures in case of tRNA damage. Probably participates to tRNA restriction-repair by ligating broken tRNA-like stem-loop structures with 2',3'-cyclic phosphate and 5'-OH ends to form a splice junction with a 2'-OH, 3',5'-phosphodiester, a step that requires GTP. Also acts as a DNA ligase in case of DNA damage by splicing 'dirty' DNA breaks, characterized by 3'-PO4 (or cyclic-PO4) and 5'-OH ends that cannot be sealed by classical DNA ligases
C1_04226	469008.B21_03223	2.9e-182	644.4	Escherichia	rtcA	GO:0003674,GO:0003824,GO:0003963,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009975,GO:0016874,GO:0016886,GO:0044424,GO:0044464,GO:0140098	6.5.1.4	ko:K01974					ko00000,ko01000				Bacteria	1MX7Q@1224,1RSFF@1236,3XMP7@561,COG0430@1,COG0430@2	NA|NA|NA	A	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP
C1_04227	155864.EDL933_4620	0.0	1778.8	Escherichia	malT	GO:0003674,GO:0003700,GO:0005488,GO:0005515,GO:0005975,GO:0006355,GO:0008150,GO:0008152,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0030246,GO:0031323,GO:0031326,GO:0042802,GO:0044238,GO:0048031,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070492,GO:0071704,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141		ko:K03556					ko00000,ko03000				Bacteria	1MVZZ@1224,1RN29@1236,3XN8M@561,COG2909@1,COG2909@2	NA|NA|NA	K	Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Binds and recognizes a DNA motif (called the malT box) 5'-GGA TG GA-3'
C1_04228	316407.85676624	0.0	1619.8	Escherichia	malP	GO:0000272,GO:0003674,GO:0003824,GO:0004645,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005980,GO:0006073,GO:0006091,GO:0006112,GO:0008144,GO:0008150,GO:0008152,GO:0008184,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0015980,GO:0016052,GO:0016740,GO:0016757,GO:0016758,GO:0019842,GO:0030170,GO:0030978,GO:0030980,GO:0031220,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901575	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931		R02111		ko00000,ko00001,ko01000		GT35	iECNA114_1301.ECNA114_3525	Bacteria	1MW4J@1224,1RN8P@1236,3XMMY@561,COG0058@1,COG0058@2	NA|NA|NA	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
C1_04229	481805.EcolC_0297	0.0	1434.5	Escherichia	malQ	GO:0000023,GO:0000025,GO:0003674,GO:0003824,GO:0004133,GO:0004134,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005984,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0015980,GO:0016052,GO:0016740,GO:0016757,GO:0016758,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046352,GO:0055114,GO:0071704,GO:1901575	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100		R05196	RC00049	ko00000,ko00001,ko01000		GH77	iECIAI1_1343.ECIAI1_3560,iECO111_1330.ECO111_4225,iECO26_1355.ECO26_4504,iEcE24377_1341.EcE24377A_3892,iJN678.malQ,iUMNK88_1353.UMNK88_4184,iYL1228.KPN_03786	Bacteria	1QTVJ@1224,1RMJW@1236,3XP9K@561,COG1640@1,COG1640@2	NA|NA|NA	G	beta-maltose 4-alpha-glucanotransferase activity
C1_04230	199310.c4192	5.7e-231	806.6	Escherichia	gntT	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008028,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0008643,GO:0015075,GO:0015128,GO:0015144,GO:0015171,GO:0015175,GO:0015238,GO:0015318,GO:0015711,GO:0015718,GO:0015804,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0022889,GO:0031224,GO:0031226,GO:0032329,GO:0034219,GO:0034220,GO:0035429,GO:0042221,GO:0042493,GO:0042873,GO:0042879,GO:0042940,GO:0042942,GO:0042943,GO:0042945,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1903825,GO:1905039		ko:K03299,ko:K06155,ko:K06157,ko:K13629,ko:K16321					ko00000,ko02000	2.A.8,2.A.8.1.2,2.A.8.1.3,2.A.8.1.4,2.A.8.1.5		iHN637.CLJU_RS05690,iSSON_1240.SSON_3547	Bacteria	1MUFG@1224,1RNGE@1236,3XNJE@561,COG2610@1,COG2610@2	NA|NA|NA	P	gluconate transporter
C1_04231	1440052.EAKF1_ch2549c	5.2e-104	383.6	Escherichia	nfuA	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010106,GO:0010467,GO:0015976,GO:0016043,GO:0016226,GO:0019538,GO:0019725,GO:0022607,GO:0030003,GO:0031163,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042592,GO:0042594,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0050896,GO:0051186,GO:0051536,GO:0051539,GO:0051540,GO:0051604,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071496,GO:0071704,GO:0071840,GO:0097428,GO:0098771,GO:1901564		ko:K07400,ko:K13628,ko:K19168					ko00000,ko02048,ko03016				Bacteria	1MU8Y@1224,1RN7J@1236,3XNB4@561,COG0316@1,COG0316@2,COG0694@1,COG0694@2	NA|NA|NA	O	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C1_04232	199310.c4190	1.6e-128	465.3	Escherichia	comF	GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0015976,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575	3.6.4.12	ko:K03654	ko03018,map03018				ko00000,ko00001,ko01000,ko03400				Bacteria	1RHAV@1224,1S64Q@1236,3XMCJ@561,COG1040@1,COG1040@2	NA|NA|NA	S	DNA utilization protein
C1_04233	198214.SF3435	3e-147	527.7	Gammaproteobacteria	bioH	GO:0003674,GO:0003824,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016787,GO:0016788,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0052689,GO:0071704,GO:0072330,GO:0090499,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.197,3.1.1.85	ko:K02169,ko:K02170	ko00780,ko01100,map00780,map01100	M00572	R09543,R09725	RC00003,RC00460,RC00461	ko00000,ko00001,ko00002,ko01000			iBWG_1329.BWG_3103,iECBD_1354.ECBD_0333,iECDH10B_1368.ECDH10B_3587,iECDH1ME8569_1439.ECDH1ME8569_3291,iETEC_1333.ETEC_3662,iEcDH1_1363.EcDH1_0301,iJO1366.b3412,iY75_1357.Y75_RS20155	Bacteria	1QUBR@1224,1RSF9@1236,COG0596@1,COG0596@2	NA|NA|NA	S	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters
C1_04234	469008.B21_03215	6.9e-164	583.2	Gammaproteobacteria	yhgA	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1990238											Bacteria	1MUSP@1224,1RNUW@1236,COG5464@1,COG5464@2	NA|NA|NA	S	Transposase
C1_04235	155864.EDL933_4611	8.5e-37	159.1	Escherichia	feoC			ko:K07490					ko00000,ko02000				Bacteria	1N73I@1224,1SDB1@1236,2E630@1,330S2@2,3XQ4D@561	NA|NA|NA	K	May function as a transcriptional regulator that controls feoABC expression
C1_04236	155864.EDL933_4610	0.0	1485.3	Escherichia	feoB	GO:0000041,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005215,GO:0005381,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006826,GO:0006950,GO:0006974,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015093,GO:0015318,GO:0015684,GO:0016020,GO:0017076,GO:0019001,GO:0022857,GO:0022890,GO:0030001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033554,GO:0034220,GO:0034755,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0044464,GO:0046873,GO:0046915,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0070838,GO:0071944,GO:0072509,GO:0072511,GO:0097159,GO:0097367,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901363,GO:1903874		ko:K04759					ko00000,ko02000	9.A.8.1		iECs_1301.ECs4251,iYL1228.KPN_03779	Bacteria	1MUZC@1224,1RME9@1236,3XNS0@561,COG0370@1,COG0370@2	NA|NA|NA	P	Transporter of a GTP-driven Fe(2 ) uptake system
C1_04237	1440052.EAKF1_ch2556c	6.5e-34	149.4	Escherichia	feoA	GO:0000041,GO:0006810,GO:0006811,GO:0006812,GO:0006826,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0015684,GO:0030001,GO:0033554,GO:0034220,GO:0034755,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0070627,GO:0070838,GO:0072511,GO:0097286,GO:0098655,GO:0098657,GO:0098659,GO:0098660,GO:0098662,GO:0098707,GO:0098711,GO:0098739,GO:0099587,GO:1903874		ko:K04758					ko00000,ko02000				Bacteria	1N8ZJ@1224,1S9TZ@1236,3XQ0E@561,COG1918@1,COG1918@2	NA|NA|NA	P	Ferrous iron transport protein A
C1_04238	481805.EcolC_0306	0.0	1503.0	Escherichia	yhgF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0044424,GO:0044444,GO:0044464,GO:0050896		ko:K06959					ko00000				Bacteria	1MUA7@1224,1RMNH@1236,3XMBH@561,COG2183@1,COG2183@2	NA|NA|NA	K	response to ionizing radiation
C1_04239	155864.EDL933_4606	1.5e-85	322.0	Escherichia	greB	GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010604,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031437,GO:0031439,GO:0032774,GO:0032784,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903311,GO:1903313,GO:1903506,GO:2000112,GO:2001141		ko:K04760					ko00000,ko03021				Bacteria	1RAP0@1224,1S40Q@1236,3XP87@561,COG0782@1,COG0782@2	NA|NA|NA	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length
C1_04240	1006000.GKAS_00792	1.4e-130	472.2	Gammaproteobacteria													Bacteria	1MY3D@1224,1RPKN@1236,COG0745@1,COG0745@2	NA|NA|NA	K	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
C1_04241	198214.SF3423	2.2e-254	884.4	Gammaproteobacteria													Bacteria	1MUAK@1224,1RPP2@1236,COG0642@1,COG2205@2	NA|NA|NA	T	PhoQ Sensor
C1_04242	199310.c4179	3.3e-46	190.7	Escherichia				ko:K07726					ko00000,ko03000				Bacteria	1N155@1224,1S7SR@1236,3XPUV@561,COG2944@1,COG2944@2	NA|NA|NA	K	Helix-turn-helix domain
C1_04243	502347.ESCAB7627_4376	5.7e-52	209.9	Escherichia													Bacteria	1N7N5@1224,1S3WA@1236,3XR3G@561,COG4737@1,COG4737@2	NA|NA|NA	S	Cytotoxic translational repressor of toxin-antitoxin stability system
C1_04244	316407.85676638	0.0	1105.1	Escherichia	pckA	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005488,GO:0005509,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0017076,GO:0019318,GO:0019319,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901576	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000			iSB619.SA_RS09060,iSF_1195.SF3422,iUTI89_1310.UTI89_C3903,iYO844.BSU30560	Bacteria	1MWXN@1224,1RPM0@1236,3XMXQ@561,COG1866@1,COG1866@2	NA|NA|NA	F	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C1_04245	198214.SF3420	0.0	1097.4	Gammaproteobacteria	yhgE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K13652					ko00000,ko03000				Bacteria	1QU1G@1224,1RSNB@1236,COG3449@1,COG3449@2	NA|NA|NA	L	Domain of unknown function (DUF4153)
C1_04246	155864.EDL933_4600	3.6e-165	587.4	Escherichia	hslO	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0006979,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0031647,GO:0036506,GO:0042026,GO:0042802,GO:0043167,GO:0043169,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0065007,GO:0065008		ko:K04083					ko00000,ko03110				Bacteria	1MUMU@1224,1RMP3@1236,3XP30@561,COG1281@1,COG1281@2	NA|NA|NA	O	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C1_04247	198214.SF3418	1.9e-65	255.0	Gammaproteobacteria	hslR	GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0003727,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009451,GO:0009628,GO:0009987,GO:0016070,GO:0033554,GO:0034605,GO:0034641,GO:0043021,GO:0043023,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363		ko:K04762					ko00000,ko03110				Bacteria	1MZR6@1224,1S8VU@1236,COG1188@1,COG1188@2	NA|NA|NA	J	Belongs to the HSP15 family
C1_04248	155864.EDL933_4598	1e-127	462.6	Escherichia	yrfG	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008477,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016798,GO:0016799,GO:0030145,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050483,GO:0050484	3.1.3.5	ko:K20881	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110		R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000				Bacteria	1NH15@1224,1RP27@1236,3XN3E@561,COG1011@1,COG1011@2	NA|NA|NA	S	GMP 5'-nucleotidase activity
C1_04249	469008.B21_03202	0.0	1417.9	Escherichia	yrfF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1N39T@1224,1RN16@1236,28IJR@1,2Z8KK@2,3XN1H@561	NA|NA|NA	S	Intracellular growth attenuator protein IgaA
C1_04250	316407.85676644	2.2e-99	368.2	Escherichia	nudE	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019144,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872		ko:K08312	ko00230,map00230		R01054	RC00002	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_3067,iE2348C_1286.E2348C_3641,iECABU_c1320.ECABU_c38150,iECED1_1282.ECED1_4056,iECNA114_1301.ECNA114_3494,iECOK1_1307.ECOK1_3810,iECP_1309.ECP_3483,iECS88_1305.ECS88_3783,iECSF_1327.ECSF_3218,iLF82_1304.LF82_1531,iNRG857_1313.NRG857_16815,iUMN146_1321.UM146_17040,iUTI89_1310.UTI89_C3895,ic_1306.c4167	Bacteria	1RCX7@1224,1S3ZE@1236,3XMNF@561,COG0494@1,COG0494@2	NA|NA|NA	L	ADP compounds hydrolase nudE
C1_04251	469008.B21_03200	0.0	1697.6	Escherichia	mrcA	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042546,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501				ko00000,ko00001,ko01000,ko01003,ko01011		GT51		Bacteria	1MU5A@1224,1RM7J@1236,3XP4D@561,COG5009@1,COG5009@2	NA|NA|NA	M	penicillin-binding protein 1A
C1_04252	469008.B21_03199	1.8e-147	528.5	Escherichia	hofM	GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0015976,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575		ko:K02461,ko:K02662,ko:K02663,ko:K12288	ko03070,ko05111,map03070,map05111	M00331			ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15			Bacteria	1RK2D@1224,1RQWR@1236,3XPHT@561,COG4972@1,COG4972@2	NA|NA|NA	NU	carbon utilization
C1_04253	198214.SF3412	3e-85	321.2	Gammaproteobacteria	hofN	GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0015976,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575		ko:K02662,ko:K02663,ko:K12279,ko:K12289					ko00000,ko02035,ko02044				Bacteria	1ND6V@1224,1SC9M@1236,COG3166@1,COG3166@2	NA|NA|NA	NU	carbon utilization
C1_04254	469008.B21_03197	9.6e-74	282.7	Escherichia	hofO	GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0015976,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575		ko:K12290					ko00000,ko02044				Bacteria	1N5KZ@1224,1S9X7@1236,2CD7R@1,32UHA@2,3XPUZ@561	NA|NA|NA	S	carbon utilization
C1_04255	316407.85676649	6.7e-74	283.1	Escherichia	hofP	GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0015976,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575		ko:K12291					ko00000,ko02044				Bacteria	1N98X@1224,1SEDR@1236,2EBIY@1,335JD@2,3XPR6@561	NA|NA|NA	S	carbon utilization
C1_04256	469008.B21_03195	4.6e-219	766.9	Escherichia	pilQ	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0015976,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575		ko:K02507,ko:K02666					ko00000,ko02035,ko02044	3.A.15.2			Bacteria	1QTT6@1224,1RN3Z@1236,3XPCW@561,COG4796@1,COG4796@2	NA|NA|NA	U	Required for the use of extracellular DNA as a nutrient. Could be the porin responsible for transport of DNA across the outer membrane
C1_04257	155864.EDL933_4588	8.7e-90	336.3	Escherichia	aroK	GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615	2.7.1.71,4.2.3.4	ko:K00891,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_1620,iECOK1_1307.ECOK1_0367,iECS88_1305.ECS88_0383,iUMN146_1321.UM146_15425,iUTI89_1310.UTI89_C0407	Bacteria	1MUFJ@1224,1RPF6@1236,3XP1J@561,COG0703@1,COG0703@2	NA|NA|NA	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C1_04258	199310.c4159	2.1e-202	711.4	Escherichia	aroB	GO:0000166,GO:0003674,GO:0003824,GO:0003856,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0051287,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000			iAF1260.b3389,iBWG_1329.BWG_3080,iECDH10B_1368.ECDH10B_3564,iECDH1ME8569_1439.ECDH1ME8569_3268,iECNA114_1301.ECNA114_3486,iEcDH1_1363.EcDH1_0324,iIT341.HP0283,iJO1366.b3389,iJR904.b3389,iY75_1357.Y75_RS20275	Bacteria	1MUBK@1224,1RN4I@1236,3XNNQ@561,COG0337@1,COG0337@2	NA|NA|NA	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C1_04259	155864.EDL933_4586	7.9e-177	626.7	Escherichia	damX	GO:0003674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0030428,GO:0032153,GO:0042834,GO:0044464,GO:0097367		ko:K03112					ko00000				Bacteria	1Q1YI@1224,1RRJF@1236,3XMJJ@561,COG3266@1,COG3266@2	NA|NA|NA	D	Cell division protein DamX
C1_04260	155864.EDL933_4585	2.4e-158	564.7	Escherichia	dam	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006281,GO:0006298,GO:0006304,GO:0006305,GO:0006306,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007049,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009007,GO:0009008,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016740,GO:0016741,GO:0022402,GO:0032259,GO:0032775,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0043412,GO:0043414,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044728,GO:0044786,GO:0044787,GO:0046483,GO:0048037,GO:0050662,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901576,GO:1901681,GO:1902292,GO:1902328,GO:1904047	2.1.1.72	ko:K06223	ko03430,map03430				ko00000,ko00001,ko01000,ko02048,ko03032,ko03400				Bacteria	1P85S@1224,1RMNW@1236,3XMRF@561,COG0338@1,COG0338@2	NA|NA|NA	L	Methylates DNA within the sequence GATC and protects the DNA from cleavage by the restriction endonuclease MboI. Although it shares sequence specificity with a number of type II restriction endonucleases and methylases, it is thought to act in postreplication mismatch repair rather than as a part of a restriction modification system. May also play a role in DNA replication
C1_04261	155864.EDL933_4584	7.7e-123	446.4	Escherichia	rpe	GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0008198,GO:0009056,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046872,GO:0046914,GO:0071704,GO:1901575	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000			iPC815.YPO0155,iYL1228.KPN_03757	Bacteria	1MUZM@1224,1RN3K@1236,3XNQC@561,COG0036@1,COG0036@2	NA|NA|NA	F	Catalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate
C1_04262	198214.SF3403	2e-140	505.0	Gammaproteobacteria	gph	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008967,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0031404,GO:0033554,GO:0034641,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130		R01334	RC00017	ko00000,ko00001,ko01000			iSBO_1134.SBO_3372,iSbBS512_1146.SbBS512_E3762,iYL1228.KPN_03756	Bacteria	1RDDY@1224,1S3QD@1236,COG0546@1,COG0546@2	NA|NA|NA	G	Phosphoglycolate phosphatase
C1_04263	316407.85676657	4.1e-189	667.2	Escherichia	trpS	GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iAF1260.b3384,iB21_1397.B21_03188,iBWG_1329.BWG_3075,iEC042_1314.EC042_3645,iECBD_1354.ECBD_0363,iECB_1328.ECB_03236,iECDH10B_1368.ECDH10B_3559,iECDH1ME8569_1439.ECDH1ME8569_3263,iECD_1391.ECD_03236,iECUMN_1333.ECUMN_3842,iECW_1372.ECW_m3639,iEKO11_1354.EKO11_0361,iEcDH1_1363.EcDH1_0329,iEcHS_1320.EcHS_A3580,iEcolC_1368.EcolC_0329,iJO1366.b3384,iLF82_1304.LF82_2316,iNRG857_1313.NRG857_16750,iPC815.YPO0157,iUMNK88_1353.UMNK88_4150,iWFL_1372.ECW_m3639,iY75_1357.Y75_RS20300	Bacteria	1MV4T@1224,1RNDC@1236,3XPGI@561,COG0180@1,COG0180@2	NA|NA|NA	J	Belongs to the class-I aminoacyl-tRNA synthetase family
C1_04264	316407.85676658	1.4e-167	595.5	Escherichia	yhfZ			ko:K03710					ko00000,ko03000				Bacteria	1PKNV@1224,1RS6T@1236,3XM6I@561,COG2188@1,COG2188@2	NA|NA|NA	K	YhfZ C-terminal domain
C1_04265	316407.85676659	1.8e-62	245.0	Escherichia	yhfY												Bacteria	1N0D7@1224,1S8TE@1236,2C4HW@1,32T80@2,3XPTF@561	NA|NA|NA	S	regulation of nucleic acid-templated transcription
C1_04266	469008.B21_03185	5.2e-220	770.0	Escherichia	yhfX												Bacteria	1QJTS@1224,1RQWY@1236,3XN0G@561,COG3457@1,COG3457@2	NA|NA|NA	E	Alanine racemase, N-terminal domain
C1_04267	469008.B21_03184	2.5e-228	797.7	Escherichia	yhfW	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008973,GO:0016853,GO:0016866,GO:0016868,GO:0044424,GO:0044444,GO:0044464										iAPECO1_1312.APECO1_3083,iEC55989_1330.EC55989_3785,iECED1_1282.ECED1_4038,iECIAI1_1343.ECIAI1_3518,iECOK1_1307.ECOK1_3793,iECS88_1305.ECS88_3765,iEcE24377_1341.EcE24377A_3849,iUMN146_1321.UM146_16955,iUTI89_1310.UTI89_C3878	Bacteria	1R4RD@1224,1RRD0@1236,3XN30@561,COG1015@1,COG1015@2	NA|NA|NA	G	phosphopentomutase activity
C1_04268	316407.85676662	7.6e-163	579.7	Escherichia	php	GO:0003674,GO:0005488,GO:0008270,GO:0043167,GO:0043169,GO:0046872,GO:0046914		ko:K07048					ko00000				Bacteria	1NPYS@1224,1RRE8@1236,3XN00@561,COG1735@1,COG1735@2	NA|NA|NA	S	Its real enzymatic activity is not yet known. It was tested for general esterase, aminopeptidase, sulfatase, phosphatase, carbonic anhydrase, phosphodiesterase, and phosphotriesterase activities with the following substrates p- nitrophenyl acetate, L-alanine nitroanilide, p-nitrophenyl sulfate, bis(p-nitrophenyl) phosphate, paraoxon, and p-nitrophenyl phosphate. No enzymatic activity was detected with any of these non-specific substrates
C1_04269	198214.SF3396	2.4e-59	234.6	Gammaproteobacteria	yhfU												Bacteria	1RHR3@1224,1T660@1236,2CDRP@1,32N2F@2	NA|NA|NA	S	Protein of unknown function DUF2620
C1_04270	199310.c4147	8.2e-230	802.7	Escherichia	yhfT	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1QMHW@1224,1RQ8K@1236,2CGY9@1,2Z8E9@2,3XQ6T@561	NA|NA|NA	S	Protein of unknown function
C1_04271	316407.85676665	4.5e-197	693.7	Escherichia	yhfS	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003961,GO:0004124,GO:0006082,GO:0006520,GO:0006534,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0017144,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071265,GO:0071266,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.48	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000				Bacteria	1Q22V@1224,1S07H@1236,3XPA6@561,COG0626@1,COG0626@2	NA|NA|NA	E	O-acetylhomoserine aminocarboxypropyltransferase activity
C1_04272	316407.85676666	3.9e-136	490.7	Escherichia	frlR	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576		ko:K02529,ko:K10711					ko00000,ko03000				Bacteria	1MZ1G@1224,1RPRE@1236,3XQ7D@561,COG2188@1,COG2188@2	NA|NA|NA	K	May regulate the transcription of the frlABCDR operon, involved in the utilization of fructoselysine and psicoselysine
C1_04273	316407.85676667	1.4e-152	545.4	Escherichia	frlD	GO:0003674,GO:0003824,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0019200,GO:0044237,GO:0044238,GO:0044262,GO:0046835,GO:0071704	2.7.1.218	ko:K10710			R08124	RC00002,RC00017	ko00000,ko01000			iECs_1301.ECs4224,iETEC_1333.ETEC_3624	Bacteria	1R6C2@1224,1RWC9@1236,3XQAZ@561,COG0524@1,COG0524@2	NA|NA|NA	F	Catalyzes the ATP-dependent phosphorylation of fructoselysine to fructoselysine 6-phosphate. Functions in a fructoselysine degradation pathway that allows E.coli to grow on fructoselysine or psicoselysine. To a much lesser extenst, is also able to phosphorylate psicoselysine
C1_04274	155864.EDL933_4578	5.7e-160	570.1	Escherichia	frlC	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006040,GO:0008150,GO:0008152,GO:0009056,GO:0016853,GO:0016854,GO:0016857,GO:0042802,GO:0046348,GO:0071704,GO:1901135,GO:1901136,GO:1901575		ko:K10709					ko00000			iECO111_1330.ECO111_4182	Bacteria	1Q64Z@1224,1S19D@1236,3XQPT@561,COG1082@1,COG1082@2	NA|NA|NA	G	Catalyzes the reversible interconversion of fructoselysine with its C-3 epimer, psicoselysine. Allows E.coli to utilize psicoselysine for growth. Does not act on psicose or fructoselysine 6-phosphate
C1_04275	198214.SF3390	3.8e-198	697.2	Gammaproteobacteria	frlB	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0016829,GO:0016835,GO:0016836,GO:0042802		ko:K10708			R08125	RC00053,RC01805	ko00000,ko01000			iSFV_1184.SFV_3377,iSFxv_1172.SFxv_3701	Bacteria	1Q9B7@1224,1RS9I@1236,COG2222@1,COG2222@2	NA|NA|NA	M	Catalyzes the reversible conversion of fructoselysine 6- phosphate to glucose 6-phosphate and lysine. Functions in a fructoselysine degradation pathway that allows E.coli to grow on fructoselysine or psicoselysine
C1_04276	316407.85676670	1.2e-247	862.1	Escherichia	frlA	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006040,GO:0006082,GO:0006520,GO:0006807,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008152,GO:0008509,GO:0008514,GO:0009056,GO:0009063,GO:0009987,GO:0015075,GO:0015171,GO:0015179,GO:0015291,GO:0015297,GO:0015318,GO:0015711,GO:0015807,GO:0015849,GO:0016020,GO:0016021,GO:0016054,GO:0019752,GO:0022804,GO:0022857,GO:0030389,GO:0030392,GO:0030393,GO:0031224,GO:0031226,GO:0034220,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044425,GO:0044459,GO:0044464,GO:0046348,GO:0046395,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0098656,GO:1901135,GO:1901136,GO:1901281,GO:1901564,GO:1901565,GO:1901575,GO:1902475,GO:1903825,GO:1905039		ko:K03294,ko:K19540					ko00000,ko02000	2.A.3.2,2.A.3.8.17		iAF1260.b3370,iB21_1397.B21_03173,iBWG_1329.BWG_3062,iEC042_1314.EC042_3632,iEC55989_1330.EC55989_3776,iECBD_1354.ECBD_0378,iECB_1328.ECB_03221,iECDH10B_1368.ECDH10B_3546,iECDH1ME8569_1439.ECDH1ME8569_3250,iECD_1391.ECD_03221,iECIAI1_1343.ECIAI1_3509,iECO111_1330.ECO111_4180,iECO26_1355.ECO26_4459,iETEC_1333.ETEC_3621,iEcDH1_1363.EcDH1_0342,iJO1366.b3370,iSSON_1240.SSON_3502,iUMNK88_1353.UMNK88_4136,iY75_1357.Y75_RS20365	Bacteria	1MXNJ@1224,1RY8P@1236,3XQUA@561,COG0531@1,COG0531@2	NA|NA|NA	E	Is likely involved in the transport of fructoselysine and psicoselysine to the cytoplasm, where they are degraded
C1_04277	155864.EDL933_4574	1.2e-24	118.2	Escherichia	yhfL												Bacteria	1NC5P@1224,1SEQS@1236,2E4XM@1,32ZRK@2,3XQ4T@561	NA|NA|NA	S	Protein of unknown function (DUF4223)
C1_04278	155864.EDL933_4573	2.1e-260	904.4	Escherichia	cysG	GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009628,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.76,2.1.1.107,2.1.1.131,3.7.1.12,4.2.1.75,4.99.1.3,4.99.1.4	ko:K02302,ko:K02303,ko:K02304,ko:K03795,ko:K13541,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03165,R03194,R03947,R05180,R05807,R05809,R07772	RC00003,RC00871,RC01012,RC01034,RC01293,RC01545,RC01861,RC02097,RC03471	ko00000,ko00001,ko00002,ko01000			iECIAI1_1343.ECIAI1_3507,iECSE_1348.ECSE_3630,iEcE24377_1341.EcE24377A_3838,iJN746.PP_3999,iPC815.YPO0158	Bacteria	1MUI0@1224,1RM9V@1236,3XP4Y@561,COG0007@1,COG0007@2,COG1648@1,COG1648@2	NA|NA|NA	H	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C1_04279	316407.85676673	8.8e-150	536.2	Escherichia	nirC	GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0008028,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015238,GO:0015318,GO:0015499,GO:0015711,GO:0015718,GO:0015724,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0042891,GO:0042895,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098656,GO:1903825,GO:1905039		ko:K02598,ko:K03459,ko:K06212,ko:K21990,ko:K21993					ko00000,ko02000	1.A.16.1.1,1.A.16.1.2,1.A.16.1.3,1.A.16.2,1.A.16.3,1.A.16.4		iB21_1397.B21_02346,iECBD_1354.ECBD_1196,iECB_1328.ECB_02384,iECD_1391.ECD_02384,iSF_1195.SF0899,iSF_1195.SF3386,iS_1188.S0963,iS_1188.S4377	Bacteria	1NBAQ@1224,1RNT4@1236,3XN3M@561,COG2116@1,COG2116@2	NA|NA|NA	P	Catalyzes nitrite uptake and nitrite export across the cytoplasmic membrane. Is up to 10-fold more active than NarK or NarU in nitrite uptake for subsequent reduction in the cytoplasm by the NirB NirD nitrite reductase
C1_04280	1440052.EAKF1_ch2598c	1e-56	225.7	Escherichia	nirD	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006091,GO:0008150,GO:0008152,GO:0008942,GO:0009061,GO:0009344,GO:0009987,GO:0015980,GO:0016491,GO:0016661,GO:0032991,GO:0044237,GO:0044424,GO:0044464,GO:0045333,GO:0046857,GO:0055114,GO:0098809	1.7.1.15	ko:K00362,ko:K00363,ko:K05710	ko00360,ko00910,ko01120,ko01220,map00360,map00910,map01120,map01220	M00530,M00545	R00787,R06782,R06783	RC00098,RC00176	br01602,ko00000,ko00001,ko00002,ko01000			iEC55989_1330.EC55989_3772	Bacteria	1MZBY@1224,1S9F1@1236,3XPX5@561,COG2146@1,COG2146@2	NA|NA|NA	P	Rieske-like [2Fe-2S] domain
C1_04281	155864.EDL933_4570	0.0	1714.5	Escherichia	nirB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006091,GO:0008150,GO:0008152,GO:0008942,GO:0009061,GO:0009344,GO:0009987,GO:0015980,GO:0016491,GO:0016661,GO:0020037,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044464,GO:0045333,GO:0046857,GO:0046906,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0051536,GO:0051540,GO:0055114,GO:0097159,GO:0098809,GO:1901265,GO:1901363	1.7.1.15	ko:K00362	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000			iECIAI39_1322.ECIAI39_3849	Bacteria	1MW58@1224,1RNGY@1236,3XM6G@561,COG1251@1,COG1251@2	NA|NA|NA	C	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1_04282	199310.c4139	1.2e-216	758.8	Escherichia	tsgA	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0010035,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0042221,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0071944,GO:0072714		ko:K02429,ko:K06141					ko00000,ko02000	2.A.1,2.A.1.7			Bacteria	1NTMP@1224,1RSCQ@1236,3XMC1@561,COG0738@1,COG0738@2	NA|NA|NA	G	response to selenite ion
C1_04283	155864.EDL933_4567	4.1e-101	374.0	Escherichia	ppiA	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005623,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0036211,GO:0042597,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0071704,GO:0140096,GO:1901564	5.2.1.8	ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217				ko00000,ko00001,ko01000,ko03110,ko04147				Bacteria	1R9ZQ@1224,1RP9U@1236,3XMM6@561,COG0652@1,COG0652@2	NA|NA|NA	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C1_04284	155864.EDL933_4566	6e-21	105.9	Escherichia	yhfG												Bacteria	1N9B8@1224,1SE93@1236,2EDND@1,337I4@2,3XQ66@561	NA|NA|NA	S	Protein of unknown function (DUF2559)
C1_04285	316407.85676679	1.4e-112	412.1	Escherichia	fic	GO:0008150,GO:0050789,GO:0050794,GO:0051302,GO:0065007		ko:K04095					ko00000,ko03036				Bacteria	1R72A@1224,1RYM7@1236,3XM4Y@561,COG2184@1,COG2184@2	NA|NA|NA	D	adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (By similarity). Involved in cell filamentation induced by cyclic AMP. May have some role in cell division
C1_04286	316407.85676680	9.3e-106	389.4	Escherichia	pabA	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0004049,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006575,GO:0006576,GO:0006586,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009108,GO:0009308,GO:0009309,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0016769,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042398,GO:0042401,GO:0042430,GO:0042435,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046820,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	2.4.2.18,2.6.1.85,4.1.3.27	ko:K01658,ko:K01664,ko:K13497	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01073,R01716	RC00010,RC00440,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_3095,iEC042_1314.EC042_3623,iECABU_c1320.ECABU_c37840,iECED1_1282.ECED1_4024,iECNA114_1301.ECNA114_3463,iECOK1_1307.ECOK1_3780,iECP_1309.ECP_3451,iECS88_1305.ECS88_3751,iECSF_1327.ECSF_3187,iLF82_1304.LF82_1586,iNRG857_1313.NRG857_16660,iSBO_1134.SBO_1803,iSbBS512_1146.SbBS512_E1488,iUMN146_1321.UM146_16880,iUTI89_1310.UTI89_C3863,ic_1306.c4135	Bacteria	1MV5Y@1224,1RMQW@1236,3XN45@561,COG0512@1,COG0512@2	NA|NA|NA	EH	Part of a heterodimeric complex that catalyzes the two- step biosynthesis of 4-amino-4-deoxychorismate (ADC), a precursor of p-aminobenzoate (PABA) and tetrahydrofolate. In the first step, a glutamine amidotransferase (PabA) generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by aminodeoxychorismate synthase (PabB) to produce ADC. PabA converts glutamine into glutamate only in the presence of stoichiometric amounts of PabB
C1_04287	316407.85676681	3e-234	817.4	Escherichia	argD	GO:0003674,GO:0003824,GO:0003992,GO:0005488,GO:0005515,GO:0006082,GO:0006105,GO:0006520,GO:0006525,GO:0006526,GO:0006527,GO:0006553,GO:0006591,GO:0006593,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009016,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009065,GO:0009066,GO:0009067,GO:0009084,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016769,GO:0017144,GO:0019545,GO:0019752,GO:0019842,GO:0030170,GO:0033359,GO:0036094,GO:0042450,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043825,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0046451,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	2.6.1.11,2.6.1.17,2.6.1.81	ko:K00821,ko:K00840	ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04217,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007			iEC55989_1330.EC55989_1916,iSFV_1184.SFV_3365,iSF_1195.SF3378,iSFxv_1172.SFxv_3689,iSSON_1240.SSON_3490,iS_1188.S4385	Bacteria	1MV3C@1224,1RMV1@1236,3XPBV@561,COG4992@1,COG4992@2	NA|NA|NA	E	Involved in both the arginine and lysine biosynthetic pathways
C1_04288	155864.EDL933_4562	0.0	1362.1	Escherichia	yhfK	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1NJVZ@1224,1RP8F@1236,3XNYG@561,COG1289@1,COG1289@2	NA|NA|NA	S	FUSC-like inner membrane protein yccS
C1_04289	1440052.EAKF1_ch2607c	1.6e-114	418.7	Escherichia	crp	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0007154,GO:0007584,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009605,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0009991,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016070,GO:0017076,GO:0018130,GO:0019001,GO:0019219,GO:0019222,GO:0019438,GO:0030551,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0032553,GO:0032555,GO:0032561,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0035438,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045013,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0045990,GO:0046483,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0061984,GO:0061985,GO:0065007,GO:0070887,GO:0071496,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140110,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141		ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111				ko00000,ko00001,ko03000				Bacteria	1MXID@1224,1RMIZ@1236,3XPHB@561,COG0664@1,COG0664@2	NA|NA|NA	K	class I promoters have a single CRP-binding site upstream of the RNA polymerase (RNAP)- binding site, whereas in class II promoters the single CRP- and RNAP-binding site overlap, CRP making multiple contacts with RNAP. Class III promoters require multiple activator molecules, including at least one CRP dimer. It can act as an activator, repressor, coactivator or corepressor. Induces a severe bend in DNA (about 87 degrees), bringing upstream promoter elements into contact with RNAP. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP. High levels of active CRP are detrimental to growth. Plays a major role in carbon catabolite repression (CCR). CCR involves cAMP, adenylate cyclase (cyaA), CRP and the EIIA-Glc component of the PTS (crr). In the presence of glucose EIIA-Glc is dephosphorylated, and does not activate adenylate cyclase, leading to reduced cAMP and thus decreased CRP activity. Also plays a role in many other processes (see PubMed 22573269)
C1_04290	155864.EDL933_4560	3.6e-67	260.8	Escherichia	yhfA			ko:K07397					ko00000				Bacteria	1RCZW@1224,1S3XF@1236,3XPIF@561,COG1765@1,COG1765@2	NA|NA|NA	O	OsmC-like protein
C1_04291	198214.SF3374	8.9e-164	582.8	Gammaproteobacteria	prkB	GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009224,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0043771,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046035,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.1.19	ko:K00855	ko00710,ko01100,ko01120,ko01200,map00710,map01100,map01120,map01200	M00165,M00166	R01523	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000				Bacteria	1MWN9@1224,1RMS7@1236,COG3954@1,COG3954@2	NA|NA|NA	G	Phosphoribulokinase
C1_04292	1440052.EAKF1_ch2610c	1.8e-33	147.9	Escherichia	yheU			ko:K07019,ko:K09898					ko00000				Bacteria	1N6TM@1224,1SCDE@1236,3XQ0T@561,COG3089@1,COG3089@2	NA|NA|NA	S	Belongs to the UPF0270 family
C1_04293	316407.85676687	2.5e-202	711.1	Escherichia	yheT	GO:0003674,GO:0003824,GO:0006629,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0044237,GO:0044238,GO:0044255,GO:0050526,GO:0052689,GO:0071704		ko:K07019					ko00000				Bacteria	1MWV1@1224,1RN39@1236,3XMVG@561,COG0429@1,COG0429@2	NA|NA|NA	S	poly(3-hydroxybutyrate) depolymerase activity
C1_04294	155864.EDL933_4556	0.0	1189.1	Escherichia	yheS	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K06158					ko00000,ko03012				Bacteria	1MU37@1224,1RPES@1236,3XNB3@561,COG0488@1,COG0488@2	NA|NA|NA	S	ABC transporter, ATP-binding protein
C1_04295	155864.EDL933_4555	2.9e-104	384.4	Escherichia	kefG			ko:K03923,ko:K11746,ko:K11748					ko00000,ko02000	2.A.37.1.1,2.A.37.1.2		iLF82_1304.LF82_1283	Bacteria	1MXFT@1224,1RMVS@1236,3XP5S@561,COG2249@1,COG2249@2	NA|NA|NA	S	Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefB
C1_04296	469008.B21_03153	0.0	1117.1	Escherichia	kefB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015318,GO:0015672,GO:0016020,GO:0016021,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098660,GO:0098662		ko:K03455,ko:K11745,ko:K11747					ko00000,ko02000	2.A.37,2.A.37.1.1,2.A.37.1.2		iB21_1397.B21_03153,iEC55989_1330.EC55989_3754,iECBD_1354.ECBD_0398,iECB_1328.ECB_03201,iECD_1391.ECD_03201,iECO26_1355.ECO26_4439,iECOK1_1307.ECOK1_0046,iECS88_1305.ECS88_0050,iECSE_1348.ECSE_3612,iECW_1372.ECW_m3606,iEKO11_1354.EKO11_0394,iEcHS_1320.EcHS_A3547,iSFV_1184.SFV_3356,iSSON_1240.SSON_3481,iUMN146_1321.UM146_23015,iUTI89_1310.UTI89_C0053,iWFL_1372.ECW_m3606,iYL1228.KPN_03736	Bacteria	1MV34@1224,1RNVR@1236,3XNFT@561,COG0475@1,COG0475@2,COG1226@1,COG1226@2	NA|NA|NA	P	Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K( ) H( ) antiport
C1_04297	155864.EDL933_4553	4.1e-32	143.3	Escherichia	yheV			ko:K07070					ko00000				Bacteria	1N6RJ@1224,1SC9Y@1236,3XQ22@561,COG3529@1,COG3529@2	NA|NA|NA	S	Probable metal-binding protein (DUF2387)
C1_04298	155864.EDL933_4552	8.3e-89	333.2	Escherichia	slyD	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006464,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010467,GO:0016151,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0022417,GO:0031647,GO:0035821,GO:0036211,GO:0042026,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043963,GO:0044003,GO:0044068,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0044501,GO:0046872,GO:0046914,GO:0050821,GO:0050896,GO:0050897,GO:0051082,GO:0051604,GO:0051701,GO:0051704,GO:0051817,GO:0052027,GO:0052250,GO:0065007,GO:0065008,GO:0071704,GO:0140096,GO:1901564	5.2.1.8	ko:K03774,ko:K03775					ko00000,ko01000,ko03110				Bacteria	1RD35@1224,1S3QR@1236,3XMA6@561,COG1047@1,COG1047@2	NA|NA|NA	O	Folding helper with both chaperone and peptidyl-prolyl cis-trans isomerase (PPIase) activities. Chaperone activity prevents aggregation of unfolded or partially folded proteins and promotes their correct folding. PPIases catalyze the cis-trans isomerization of Xaa-Pro bonds of peptides, which accelerates slow steps of protein folding and thus shortens the lifetime of intermediates. Both strategies lower the concentration of intermediates and increase the productivity and yield of the folding reaction. SlyD could be involved in Tat-dependent translocation, by binding to the Tat-type signal of folded proteins
C1_04299	155864.EDL933_4551	1.9e-30	137.9	Escherichia	slyX			ko:K03745					ko00000				Bacteria	1NGFM@1224,1SGAM@1236,3XPZ6@561,COG2900@1,COG2900@2	NA|NA|NA	S	Belongs to the SlyX family
C1_04300	155864.EDL933_4550	1.1e-139	502.7	Escherichia	fkpA	GO:0005575,GO:0005623,GO:0006457,GO:0008150,GO:0009987,GO:0030288,GO:0030313,GO:0031975,GO:0042026,GO:0042597,GO:0044464	5.2.1.8	ko:K03772					ko00000,ko01000,ko03110				Bacteria	1RDA1@1224,1RRKU@1236,3XN8I@561,COG0545@1,COG0545@2	NA|NA|NA	M	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C1_04301	198214.SF3364	7e-130	469.9	Gammaproteobacteria	yheO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Bacteria	1MU5K@1224,1RPDQ@1236,COG2964@1,COG2964@2	NA|NA|NA	S	protein conserved in bacteria
C1_04302	469008.B21_03147	1.8e-63	248.4	Escherichia	tusD	GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006790,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0019417,GO:0032991,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055114,GO:0071704,GO:0090304,GO:0097163,GO:0140104,GO:1901360,GO:1902494,GO:1990228,GO:1990234		ko:K07235	ko04122,map04122				ko00000,ko00001,ko01000,ko03016				Bacteria	1N021@1224,1S99J@1236,3XPIA@561,COG1553@1,COG1553@2	NA|NA|NA	J	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C1_04303	469008.B21_03146	1.7e-60	238.4	Escherichia	tusC	GO:0002097,GO:0002098,GO:0002143,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1902494,GO:1990228,GO:1990234		ko:K07236	ko04122,map04122				ko00000,ko00001,ko03016				Bacteria	1N8RV@1224,1SD0S@1236,3XPSC@561,COG2923@1,COG2923@2	NA|NA|NA	J	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions
C1_04304	469008.B21_03145	3.2e-46	190.7	Escherichia	tusB	GO:0002097,GO:0002098,GO:0002143,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1902494,GO:1990228,GO:1990234		ko:K07237	ko04122,map04122				ko00000,ko00001,ko03016				Bacteria	1NGF3@1224,1SGPI@1236,3XPX0@561,COG2168@1,COG2168@2	NA|NA|NA	J	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions
C1_04305	1005994.GTGU_03045	5.8e-64	250.0	Gammaproteobacteria	rpsL	GO:0000372,GO:0000375,GO:0000376,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008380,GO:0009058,GO:0009059,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010604,GO:0010628,GO:0015935,GO:0016070,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0031323,GO:0031325,GO:0032991,GO:0033120,GO:0034336,GO:0034337,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043484,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990145,GO:1990904		ko:K02950	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1RCWY@1224,1S3WB@1236,COG0048@1,COG0048@2	NA|NA|NA	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C1_04306	1440052.EAKF1_ch2624	1.1e-78	299.3	Escherichia	rpsG	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0016020,GO:0016043,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113		ko:K02992	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1MXC8@1224,1RN77@1236,3XMJS@561,COG0049@1,COG0049@2	NA|NA|NA	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center
C1_04307	1440052.EAKF1_ch2625	0.0	1397.5	Escherichia	fusA	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576		ko:K02355					ko00000,ko03012,ko03029				Bacteria	1MUCV@1224,1RNSZ@1236,3XMEB@561,COG0480@1,COG0480@2	NA|NA|NA	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C1_04308	1440052.EAKF1_ch2626	1.1e-225	788.9	Escherichia	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944		ko:K02358					ko00000,ko03012,ko03029,ko04147				Bacteria	1MVC0@1224,1RMYX@1236,3XN6C@561,COG0050@1,COG0050@2	NA|NA|NA	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C1_04309	155864.EDL933_4541	4.9e-30	136.3	Escherichia	bfd	GO:0003674,GO:0005488,GO:0048037,GO:0051536,GO:0051537,GO:0051540		ko:K02192					ko00000				Bacteria	1N86H@1224,1SCIU@1236,3XQ0Z@561,COG2906@1,COG2906@2	NA|NA|NA	P	could be a general redox and or regulatory component participating in the iron storage mobilization functions of BFR. Could participate in the release or the delivery of iron from to bacterioferritin (or other iron complexes)
C1_04310	198214.SF3355	2.2e-84	318.2	Gammaproteobacteria	bfr	GO:0003674,GO:0003824,GO:0004322,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016722,GO:0016724,GO:0019725,GO:0020037,GO:0030003,GO:0042592,GO:0042802,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046906,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0051179,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0097159,GO:0097577,GO:0098771,GO:1901363	1.16.3.1	ko:K03594	ko00860,map00860		R00078	RC02758	ko00000,ko00001,ko01000				Bacteria	1RCW7@1224,1S45S@1236,COG2193@1,COG2193@2	NA|NA|NA	P	Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex
C1_04311	754331.AEME01000001_gene3765	7.5e-77	293.1	Escherichia	hopD		3.4.23.43	ko:K02464,ko:K02506,ko:K02654	ko03070,map03070	M00331			ko00000,ko00001,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15,3.A.15.2			Bacteria	1MUZF@1224,1RN90@1236,3XPSX@561,COG1989@1,COG1989@2	NA|NA|NA	NOU	Type IV leader peptidase family
C1_04312	1440052.EAKF1_ch2630	1.5e-49	201.8	Escherichia	rpsJ	GO:0001072,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006355,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0015935,GO:0019219,GO:0019222,GO:0019538,GO:0022626,GO:0022627,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043244,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0140110,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2001141		ko:K02946	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1RGWF@1224,1S3QX@1236,3XPQU@561,COG0051@1,COG0051@2	NA|NA|NA	J	Involved in the binding of tRNA to the ribosomes
C1_04313	155864.EDL933_4537	6.3e-111	406.8	Escherichia	rplC	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010604,GO:0010628,GO:0015934,GO:0016020,GO:0016043,GO:0019219,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0031323,GO:0031325,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000232,GO:2000234		ko:K02906	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1MUST@1224,1RMK9@1236,3XNYM@561,COG0087@1,COG0087@2	NA|NA|NA	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C1_04314	1005994.GTGU_03023	1.8e-102	378.6	Gammaproteobacteria	rplD	GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003700,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0005886,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008428,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030234,GO:0030312,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032069,GO:0032074,GO:0032268,GO:0032269,GO:0032991,GO:0032993,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042788,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060698,GO:0060699,GO:0060700,GO:0060701,GO:0060702,GO:0065003,GO:0065007,GO:0065009,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:0098772,GO:0140110,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990904,GO:2000112,GO:2000113,GO:2001141		ko:K02926,ko:K16193	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1MXPF@1224,1RNNK@1236,COG0088@1,COG0088@2	NA|NA|NA	J	Forms part of the polypeptide exit tunnel
C1_04315	1440052.EAKF1_ch2633	1.7e-45	188.3	Escherichia	rplW	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02892	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1MZXX@1224,1S8VX@1236,3XPXA@561,COG0089@1,COG0089@2	NA|NA|NA	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
C1_04316	1073999.BN137_4054	2.3e-153	548.1	Gammaproteobacteria	rplB	GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02886	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1MVTD@1224,1RMGR@1236,COG0090@1,COG0090@2	NA|NA|NA	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C1_04317	1006000.GKAS_02813	9.1e-46	189.1	Gammaproteobacteria	rpsS	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02965	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1RGYX@1224,1S5VT@1236,COG0185@1,COG0185@2	NA|NA|NA	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C1_04318	1073999.BN137_4056	1e-51	209.1	Gammaproteobacteria	rplV	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042788,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02890	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1RH0W@1224,1S5XT@1236,COG0091@1,COG0091@2	NA|NA|NA	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C1_04319	1005994.GTGU_03018	3.8e-125	454.1	Gammaproteobacteria	rpsC	GO:0000028,GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02982	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1MUAI@1224,1RN0P@1236,COG0092@1,COG0092@2	NA|NA|NA	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C1_04320	1440052.EAKF1_ch2638	1.1e-68	265.8	Escherichia	rplP	GO:0000027,GO:0000049,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02878	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1RA0Z@1224,1S201@1236,3XPK2@561,COG0197@1,COG0197@2	NA|NA|NA	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C1_04321	155864.EDL933_4529	9.7e-23	112.1	Escherichia	rpmC	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02904	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1N6PR@1224,1SCBN@1236,3XPZK@561,COG0255@1,COG0255@2	NA|NA|NA	J	ribosomal protein L29
C1_04322	1224318.DT73_19190	4e-40	170.2	Gammaproteobacteria	rpsQ	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046677,GO:0050896,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02961	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1MZIK@1224,1S8SS@1236,COG0186@1,COG0186@2	NA|NA|NA	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C1_04323	198214.SF3342	1.2e-61	242.3	Gammaproteobacteria	rplN	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02874	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1RCWZ@1224,1S3Z3@1236,COG0093@1,COG0093@2	NA|NA|NA	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C1_04324	1045856.EcWSU1_04111	4.5e-49	200.3	Enterobacter	rplX	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02895	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1MZQD@1224,1S973@1236,3X2E6@547,COG0198@1,COG0198@2	NA|NA|NA	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C1_04325	1166130.H650_13010	2.4e-95	354.8	Enterobacter	rplE	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02931	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1MUU9@1224,1RPE1@1236,3X0U0@547,COG0094@1,COG0094@2	NA|NA|NA	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C1_04326	1005994.GTGU_03011	9.6e-49	199.1	Gammaproteobacteria	rpsN	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02954	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1MZDT@1224,1S62N@1236,COG0199@1,COG0199@2	NA|NA|NA	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C1_04327	1114922.CIFAM_27_00220	2.8e-64	251.1	Citrobacter	rpsH	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009894,GO:0009987,GO:0010467,GO:0010468,GO:0010608,GO:0015935,GO:0016043,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031323,GO:0031329,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043487,GO:0043488,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0061013,GO:0065003,GO:0065007,GO:0065008,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903311,GO:1990904		ko:K02994	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1RDG3@1224,1S452@1236,3WYA3@544,COG0096@1,COG0096@2	NA|NA|NA	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C1_04328	155864.EDL933_4522	2.3e-93	348.2	Escherichia	rplF	GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02933	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1R9YZ@1224,1S1Z1@1236,3XPDH@561,COG0097@1,COG0097@2	NA|NA|NA	J	is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C1_04329	1006000.GKAS_02825	5.2e-54	216.9	Gammaproteobacteria	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02881	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1RGY7@1224,1S5V2@1236,COG0256@1,COG0256@2	NA|NA|NA	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C1_04330	1114922.CIFAM_27_00250	8.1e-85	319.7	Citrobacter	rpsE	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990145,GO:1990904		ko:K02988	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1MUS4@1224,1RNEV@1236,3WV8F@544,COG0098@1,COG0098@2	NA|NA|NA	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C1_04331	1440052.EAKF1_ch2649	6.3e-24	115.9	Escherichia	rpmD	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02907	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1N6ZE@1224,1SC8N@1236,3XQ3P@561,COG1841@1,COG1841@2	NA|NA|NA	J	structural constituent of ribosome
C1_04332	1114922.CIFAM_27_00270	4.7e-65	253.8	Citrobacter	rplO	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02876	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1RDC8@1224,1S3P6@1236,3WY82@544,COG0200@1,COG0200@2	NA|NA|NA	J	binds to the 23S rRNA
C1_04333	155864.EDL933_4517	1e-243	849.0	Escherichia	secY	GO:0002790,GO:0003674,GO:0005048,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0031522,GO:0032940,GO:0032978,GO:0032991,GO:0033036,GO:0033218,GO:0033365,GO:0034613,GO:0042277,GO:0042886,GO:0042887,GO:0043952,GO:0044425,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680		ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044	3.A.5			Bacteria	1MVU7@1224,1RNJV@1236,3XNT2@561,COG0201@1,COG0201@2	NA|NA|NA	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
C1_04334	1005994.GTGU_03003	1.2e-12	77.8	Gammaproteobacteria	rpmJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02919	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1NGEI@1224,1SGC9@1236,COG0257@1,COG0257@2	NA|NA|NA	J	Belongs to the bacterial ribosomal protein bL36 family
C1_04335	155864.EDL933_4515	1.5e-56	225.3	Escherichia	rpsM	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02952	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1RD1G@1224,1S3NX@1236,3XPPN@561,COG0099@1,COG0099@2	NA|NA|NA	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C1_04336	1114922.CIFAM_27_00300	7.7e-67	259.6	Citrobacter	rpsK	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02948	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1RD0A@1224,1S3Q2@1236,3WY9K@544,COG0100@1,COG0100@2	NA|NA|NA	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C1_04337	199310.c4057	8.4e-108	396.4	Escherichia	rpsD	GO:0000028,GO:0000900,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006355,GO:0006412,GO:0006417,GO:0006446,GO:0006450,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0010629,GO:0015935,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030371,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031554,GO:0031564,GO:0032268,GO:0032269,GO:0032270,GO:0032991,GO:0034248,GO:0034249,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043244,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0045727,GO:0045903,GO:0045947,GO:0048027,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051247,GO:0051248,GO:0051252,GO:0060255,GO:0065003,GO:0065007,GO:0065008,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090079,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990145,GO:1990904,GO:2000112,GO:2000113,GO:2001141		ko:K02986	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1MW0U@1224,1RQ38@1236,3XNVS@561,COG0522@1,COG0522@2	NA|NA|NA	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C1_04338	1114922.CIFAM_27_00320	1.8e-181	641.7	Citrobacter	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400				Bacteria	1MU75@1224,1RMU3@1236,3WW1W@544,COG0202@1,COG0202@2	NA|NA|NA	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C1_04339	1399774.JDWH01000027_gene3583	1.6e-61	241.9	Enterobacter	rplQ	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02879,ko:K16193	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1RCWN@1224,1S3QK@1236,3X29H@547,COG0203@1,COG0203@2	NA|NA|NA	J	Ribosomal protein L17
C1_04340	316407.85676748	5.8e-64	250.0	Escherichia	yhdN												Bacteria	1NAHU@1224,1S9DD@1236,2D7FD@1,32TNY@2,3XPSQ@561	NA|NA|NA	S	Domain of unknown function (DUF1992)
C1_04341	155864.EDL933_4509	6.6e-72	276.6	Escherichia	zntR	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0046872,GO:0046914,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141		ko:K13638,ko:K19591		M00769			ko00000,ko00002,ko01504,ko03000				Bacteria	1MZ3P@1224,1SA5G@1236,3XPN1@561,COG0789@1,COG0789@2	NA|NA|NA	K	Transcriptional regulator
C1_04342	316407.85676750	3.7e-34	150.2	Escherichia	arfA	GO:0000049,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0006412,GO:0006414,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0019222,GO:0019538,GO:0031323,GO:0031326,GO:0032268,GO:0034248,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0072344,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112		ko:K09890					ko00000,ko03012				Bacteria	1N709@1224,1SDRD@1236,3XQ3B@561,COG3036@1,COG3036@2	NA|NA|NA	S	Rescues ribosomes stalled at the 3' end of non-stop mRNAs. This activity is crucial when the stalled ribosome cannot be rescued by the SsrA(tmRNA)- SmpB quality control system. Binds the 30S subunit, contacting 16S rRNA with the N-terminus near the decoding center and its C-terminus in the mRNA entry channel
C1_04343	155864.EDL933_4508	2.6e-65	254.6	Escherichia	mscL	GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015075,GO:0015267,GO:0015318,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022838,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0034220,GO:0042592,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066		ko:K03282					ko00000,ko02000	1.A.22.1			Bacteria	1RHG8@1224,1S3PD@1236,3XPMG@561,COG1970@1,COG1970@2	NA|NA|NA	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
C1_04344	155864.EDL933_4507	9.5e-253	879.0	Escherichia	trkA	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0015075,GO:0015672,GO:0016020,GO:0022857,GO:0030001,GO:0034220,GO:0051179,GO:0051234,GO:0055085,GO:0098655		ko:K03499,ko:K05571					ko00000,ko02000	2.A.38.1,2.A.38.4,2.A.63.1,2.A.63.2		iE2348C_1286.E2348C_3552	Bacteria	1MW8R@1224,1RNVQ@1236,3XNHZ@561,COG0569@1,COG0569@2	NA|NA|NA	P	Part of the constitutive potassium transport systems TrkG and TrkH. May regulate the transport activity of TrkG and TrkH systems. Binds to NAD( ) and NADH
C1_04345	316407.85676753	3.7e-251	873.6	Escherichia	sun	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.176	ko:K03500					ko00000,ko01000,ko03009				Bacteria	1MWPE@1224,1RN8X@1236,3XN6S@561,COG0144@1,COG0144@2,COG0781@1,COG0781@2	NA|NA|NA	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C1_04346	155864.EDL933_4505	2.2e-176	624.8	Escherichia	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006418,GO:0006431,GO:0006464,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019752,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.1.176,2.1.2.9	ko:K00604,ko:K03500	ko00670,ko00970,map00670,map00970		R03940	RC00026,RC00165	ko00000,ko00001,ko01000,ko03009			iECABU_c1320.ECABU_c37050,iECUMN_1333.ECUMN_3761,ic_1306.c4048	Bacteria	1MU4Q@1224,1RP1T@1236,3XNR9@561,COG0223@1,COG0223@2	NA|NA|NA	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C1_04347	155864.EDL933_4504	1.1e-86	325.9	Escherichia	def	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0008463,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043021,GO:0043022,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046872,GO:0046914,GO:0071704,GO:1901564	3.5.1.88	ko:K01462					ko00000,ko01000				Bacteria	1RA2P@1224,1S247@1236,3XNEA@561,COG0242@1,COG0242@2	NA|NA|NA	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
C1_04348	316407.85676756	1.1e-211	742.3	Escherichia	dprA			ko:K04096					ko00000				Bacteria	1MVF6@1224,1RPJE@1236,3XP00@561,COG0758@1,COG0758@2	NA|NA|NA	LU	Partially complements natural chromosomal DNA transformation defect of an H.influenzae dprA disruption mutant. May help load RecA onto ssDNA (By similarity)
C1_04349	155864.EDL933_4502	1.2e-82	312.4	Escherichia	smg			ko:K03747					ko00000				Bacteria	1RD5F@1224,1S43X@1236,3XQIC@561,COG2922@1,COG2922@2	NA|NA|NA	S	Belongs to the Smg family
C1_04350	316407.85676758	1.9e-84	318.5	Escherichia	yrdD	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005506,GO:0008270,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0097159,GO:1901363		ko:K07479					ko00000				Bacteria	1MX2E@1224,1RQ85@1236,3XN35@561,COG0551@1,COG0551@2	NA|NA|NA	L	DNA topological change
C1_04351	155864.EDL933_4500	1.6e-105	388.7	Escherichia	tsaC	GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061710,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363	2.7.7.87	ko:K07479,ko:K07566			R10463	RC00745	ko00000,ko01000,ko03009,ko03016				Bacteria	1MVPM@1224,1S610@1236,3XN9Z@561,COG0009@1,COG0009@2	NA|NA|NA	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-) CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate
C1_04352	198214.SF3313	8.1e-151	539.7	Gammaproteobacteria	aroE	GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615	1.1.1.25,1.1.1.282	ko:K00014,ko:K05887	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01872,R02413,R06846,R06847	RC00154,RC00206	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_3165,iECOK1_1307.ECOK1_3701,iECS88_1305.ECS88_3669,iECUMN_1333.ECUMN_3755,iSBO_1134.SBO_3275,iSFxv_1172.SFxv_1929,iS_1188.S1854,iUMN146_1321.UM146_16315,iUTI89_1310.UTI89_C3726	Bacteria	1MVH4@1224,1RPB7@1236,COG0169@1,COG0169@2	NA|NA|NA	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C1_04353	316407.85676761	9.3e-45	185.7	Escherichia	yrdB												Bacteria	1N7X6@1224,1SC8J@1236,2E6QS@1,331AY@2,3XQ1C@561	NA|NA|NA	S	Protein of unknown function (DUF1488)
C1_04354	155864.EDL933_4497	2e-92	345.1	Escherichia	yrdA	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008270,GO:0009987,GO:0016043,GO:0022607,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071840		ko:K08279,ko:K08699					ko00000				Bacteria	1RD76@1224,1RPB6@1236,3XNFA@561,COG0663@1,COG0663@2	NA|NA|NA	S	protein homotrimerization
C1_04362	155864.EDL933_4495	1.4e-141	508.8	Escherichia	yhdZ	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	3.6.3.21	ko:K02028,ko:K09972,ko:K10004	ko02010,ko02020,map02010,map02020	M00230,M00232,M00236			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3,3.A.1.3.17,3.A.1.3.18,3.A.1.3.19,3.A.1.3.4,3.A.1.3.7,3.A.1.3.8		iAPECO1_1312.APECO1_1411,iE2348C_1286.E2348C_0545,iECOK1_1307.ECOK1_0655,iECP_1309.ECP_0675,iECS88_1305.ECS88_0687,iEcSMS35_1347.EcSMS35_0673,iJN746.PP_1300,iUMN146_1321.UM146_14290,iUTI89_1310.UTI89_C0648	Bacteria	1MU9Q@1224,1RMX1@1236,3XMTZ@561,COG1126@1,COG1126@2	NA|NA|NA	P	amino-acid ABC transporter ATP-binding protein YhdZ
C1_04363	198214.SF3309	1.4e-209	735.3	Gammaproteobacteria	yhdY	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K02029,ko:K09971	ko02010,map02010	M00232,M00236			ko00000,ko00001,ko00002,ko02000	3.A.1.3,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8			Bacteria	1MV3I@1224,1RPJR@1236,COG0765@1,COG0765@2	NA|NA|NA	P	amino acid ABC transporter
C1_04364	316407.85676060	1.4e-212	745.3	Escherichia	yhdX	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K09970	ko02010,map02010	M00232			ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8			Bacteria	1MV0S@1224,1RN6V@1236,3XNNW@561,COG4597@1,COG4597@2	NA|NA|NA	P	amino-acid ABC transporter permease protein YhdX
C1_04365	155864.EDL933_4492	1.7e-193	681.8	Escherichia	aapJ	GO:0005575,GO:0005623,GO:0042597,GO:0044464		ko:K09969	ko02010,map02010	M00232			ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8			Bacteria	1MV5D@1224,1RNJJ@1236,3XMWH@561,COG0834@1,COG0834@2	NA|NA|NA	ET	amino-acid ABC
C1_04366	1114922.CIFAM_19_00050	1.8e-33	147.9	Citrobacter	yhdV												Bacteria	1N0QR@1224,1S8YI@1236,2CDN7@1,32RY2@2,3WYRQ@544	NA|NA|NA	S	Protein involved in biological_process
C1_04368	481805.EcolC_0440	0.0	1941.0	Escherichia	acrF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K18138,ko:K18142,ko:K18899	ko01501,ko01503,map01501,map01503	M00647,M00696,M00697,M00699,M00718			ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2,2.A.6.2.13		iAF1260.b3266,iJO1366.b3266,iZ_1308.Z4627	Bacteria	1MU48@1224,1RMBN@1236,3XP6I@561,COG0841@1,COG0841@2	NA|NA|NA	U	efflux transmembrane transporter activity
C1_04369	316407.85676056	4.9e-210	736.9	Escherichia	acrE	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0006869,GO:0008150,GO:0010876,GO:0015238,GO:0015711,GO:0015718,GO:0015721,GO:0015849,GO:0015850,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0032991,GO:0033036,GO:0042221,GO:0042493,GO:0042597,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098796,GO:1902495,GO:1990281,GO:1990351		ko:K03585,ko:K18141,ko:K18898	ko01501,ko01503,map01501,map01503	M00646,M00647,M00696,M00697,M00699,M00718			ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1,8.A.1.6,8.A.1.6.3		iSDY_1059.SDY_0456	Bacteria	1MU78@1224,1RPI1@1236,3XNKF@561,COG0845@1,COG0845@2	NA|NA|NA	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1_04370	155864.EDL933_4486	1.3e-119	435.6	Escherichia	ttgR	GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042221,GO:0042493,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K03577,ko:K18140		M00647,M00696			ko00000,ko00002,ko01504,ko03000				Bacteria	1RCKE@1224,1S3A5@1236,3XP9B@561,COG1309@1,COG1309@2	NA|NA|NA	K	acrEF envCD operon repressor
C1_04371	199310.c4029	1.9e-25	120.9	Escherichia	yhdU												Bacteria	1N88G@1224,1SD0T@1236,2E736@1,331MQ@2,3XR8B@561	NA|NA|NA	S	Protein of unknown function (DUF2556)
C1_04372	316407.85676053	3.5e-168	597.4	Escherichia	yhdJ	GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006304,GO:0006305,GO:0006306,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009007,GO:0009008,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0032775,GO:0034641,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044728,GO:0046483,GO:0071704,GO:0090304,GO:0140097,GO:1901360	2.1.1.72	ko:K00571,ko:K07319					ko00000,ko01000,ko02048				Bacteria	1MX9M@1224,1S17I@1236,3XMME@561,COG2189@1,COG2189@2	NA|NA|NA	L	Belongs to the N(4) N(6)-methyltransferase family
C1_04373	1005994.GTGU_03789	9.7e-46	189.1	Gammaproteobacteria	fis	GO:0000018,GO:0000229,GO:0000785,GO:0000786,GO:0000787,GO:0000789,GO:0000976,GO:0000984,GO:0000985,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008301,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016032,GO:0016070,GO:0018130,GO:0019042,GO:0019045,GO:0019046,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031421,GO:0032359,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0042803,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044374,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044427,GO:0044444,GO:0044446,GO:0044464,GO:0044815,GO:0045892,GO:0045893,GO:0045911,GO:0045934,GO:0045935,GO:0046483,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051704,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K03557,ko:K07712	ko02020,ko05111,map02020,map05111	M00497			ko00000,ko00001,ko00002,ko02022,ko03000,ko03036,ko03400				Bacteria	1N7MJ@1224,1SD35@1236,COG2901@1,COG2901@2	NA|NA|NA	K	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C1_04374	199310.c4026	4.7e-182	643.7	Escherichia	dusB	GO:0002943,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009314,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016491,GO:0016627,GO:0017150,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0050896,GO:0055114,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360		ko:K05539,ko:K05540					ko00000,ko01000,ko03016				Bacteria	1MV5V@1224,1RMJP@1236,3XNH8@561,COG0042@1,COG0042@2	NA|NA|NA	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C1_04375	155864.EDL933_4481	1.6e-168	598.6	Escherichia	prmA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006480,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016278,GO:0016279,GO:0016740,GO:0016741,GO:0018011,GO:0018012,GO:0018022,GO:0018023,GO:0018193,GO:0018194,GO:0018205,GO:0019538,GO:0031365,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564		ko:K02687					ko00000,ko01000,ko03009				Bacteria	1MUPC@1224,1RNAR@1236,3XPE5@561,COG2264@1,COG2264@2	NA|NA|NA	J	Methylates ribosomal protein L11
C1_04376	155864.EDL933_4480	1.8e-254	884.8	Escherichia	panF	GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0008028,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015233,GO:0015238,GO:0015291,GO:0015293,GO:0015318,GO:0015711,GO:0015718,GO:0015849,GO:0015887,GO:0015893,GO:0016020,GO:0022804,GO:0022857,GO:0034220,GO:0035461,GO:0042221,GO:0042493,GO:0042886,GO:0042887,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051180,GO:0051181,GO:0051182,GO:0051184,GO:0051185,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0072349,GO:0090482,GO:0098656,GO:1903825,GO:1905039		ko:K03307,ko:K14392					ko00000,ko02000	2.A.21,2.A.21.1		iE2348C_1286.E2348C_3528,iECED1_1282.ECED1_3917,iECP_1309.ECP_3351	Bacteria	1QUAY@1224,1RP9P@1236,3XNIQ@561,COG4145@1,COG4145@2	NA|NA|NA	H	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1_04377	155864.EDL933_4479	2.2e-40	171.0	Escherichia	yhdT												Bacteria	1MZ8K@1224,1S8QV@1236,3XPXX@561,COG3924@1,COG3924@2	NA|NA|NA	S	Protein of unknown function (DUF997)
C1_04378	362663.ECP_3349	7.9e-182	642.9	Proteobacteria	scrK		2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100		R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000				Bacteria	1NF0X@1224,COG0524@1,COG0524@2	NA|NA|NA	G	PFAM PfkB domain protein
C1_04379	362663.ECP_3348	1.2e-146	525.8	Gammaproteobacteria													Bacteria	1R3QU@1224,1S1NZ@1236,COG1349@1,COG1349@2	NA|NA|NA	K	Transcriptional
C1_04380	199310.c4018	1.6e-157	562.0	Escherichia	kbaY		4.1.2.40	ko:K08302	ko00052,ko01100,map00052,map01100		R01069	RC00438,RC00439	ko00000,ko00001,ko01000			iAF1260.b3137,iAPECO1_1312.APECO1_3290,iB21_1397.B21_02955,iBWG_1329.BWG_2841,iEC042_1314.EC042_3431,iEC55989_1330.EC55989_3557,iECABU_c1320.ECABU_c35530,iECBD_1354.ECBD_0603,iECB_1328.ECB_03004,iECDH10B_1368.ECDH10B_3310,iECDH1ME8569_1439.ECDH1ME8569_3028,iECD_1391.ECD_03004,iECED1_1282.ECED1_3801,iECH74115_1262.ECH74115_4454,iECIAI1_1343.ECIAI1_3287,iECO103_1326.ECO103_3884,iECO111_1330.ECO111_3961,iECO26_1355.ECO26_4242,iECOK1_1307.ECOK1_3561,iECP_1309.ECP_3229,iECS88_1305.ECS88_3525,iECSE_1348.ECSE_3423,iECSP_1301.ECSP_4111,iECW_1372.ECW_m3407,iECs_1301.ECs4017,iEKO11_1354.EKO11_0580,iETEC_1333.ETEC_3404,iEcDH1_1363.EcDH1_0568,iEcE24377_1341.EcE24377A_3619,iEcHS_1320.EcHS_A3329,iEcolC_1368.EcolC_0561,iG2583_1286.G2583_2628,iG2583_1286.G2583_3861,iJO1366.b3137,iJR904.b3137,iLF82_1304.LF82_1138,iNRG857_1313.NRG857_15590,iUMN146_1321.UM146_00665,iUMNK88_1353.UMNK88_3896,iUTI89_1310.UTI89_C3568,iWFL_1372.ECW_m3407,iY75_1357.Y75_RS16275,iZ_1308.Z4491,ic_1306.c3894	Bacteria	1MURX@1224,1RQUC@1236,3XPA4@561,COG0191@1,COG0191@2	NA|NA|NA	F	which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6- bisphosphate (TBP). Requires
C1_04381	199310.c4017	1e-154	552.7	Escherichia	rbsB			ko:K10439	ko02010,ko02030,map02010,map02030	M00212			ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19			Bacteria	1NRXG@1224,1RP6T@1236,3XRFX@561,COG1879@1,COG1879@2	NA|NA|NA	G	Periplasmic binding protein domain
C1_04382	362663.ECP_3345	1.5e-275	954.9	Escherichia	rbsA		3.6.3.17	ko:K10441,ko:K17215	ko02010,map02010	M00212,M00593			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19			Bacteria	1MU22@1224,1RMCH@1236,3XN9K@561,COG1129@1,COG1129@2	NA|NA|NA	P	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system
C1_04383	362663.ECP_3344	7.2e-170	603.2	Gammaproteobacteria				ko:K10440	ko02010,map02010	M00212			ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19			Bacteria	1QICJ@1224,1RYUV@1236,COG1172@1,COG1172@2	NA|NA|NA	G	Belongs to the binding-protein-dependent transport system permease family
C1_04384	199310.c4014	1.9e-183	648.3	Gammaproteobacteria	scrK		2.7.1.101,2.7.1.4	ko:K00847,ko:K21621	ko00051,ko00052,ko00500,ko00520,ko01100,map00051,map00052,map00500,map00520,map01100		R00760,R00867,R02927,R03920	RC00002,RC00017,RC00810	ko00000,ko00001,ko01000				Bacteria	1MX38@1224,1RRWT@1236,COG0524@1,COG0524@2	NA|NA|NA	G	Belongs to the carbohydrate kinase PfkB family
C1_04385	362663.ECP_3342	6.8e-203	713.0	Escherichia													Bacteria	1MVUY@1224,1RQ29@1236,3XR9C@561,COG2017@1,COG2017@2	NA|NA|NA	G	Domain of unknown function (DUF4432)
C1_04386	316407.85676047	8.7e-259	899.0	Escherichia	accC	GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000			iSF_1195.SF3294	Bacteria	1MU4H@1224,1RMNB@1236,3XP5G@561,COG0439@1,COG0439@2	NA|NA|NA	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
C1_04387	155864.EDL933_4477	4.2e-75	287.3	Escherichia	accB	GO:0003674,GO:0003824,GO:0003989,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009305,GO:0009987,GO:0016049,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901576	2.3.1.12	ko:K00627,ko:K02160	ko00010,ko00020,ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00010,map00020,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00307,M00376	R00209,R00742,R02569	RC00004,RC00040,RC00367,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000			iYL1228.KPN_03664	Bacteria	1RCXA@1224,1S3YP@1236,3XM9J@561,COG0511@1,COG0511@2	NA|NA|NA	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
C1_04388	481805.EcolC_0453	2.2e-156	558.1	Gammaproteobacteria													Bacteria	1NE0R@1224,1SDSW@1236,COG4848@1,COG4848@2	NA|NA|NA	S	Belongs to the UPF0354 family
C1_04389	155864.EDL933_4474	3.1e-181	641.0	Escherichia	yhdH	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016627,GO:0016628,GO:0043957,GO:0055114		ko:K19745	ko00640,ko01100,map00640,map01100		R00919	RC00095	ko00000,ko00001,ko01000				Bacteria	1MV3W@1224,1RMHG@1236,3XP5P@561,COG0604@1,COG0604@2	NA|NA|NA	C	acryloyl-CoA reductase (NADP+) activity
C1_04390	316407.85676044	0.0	1267.3	Escherichia	csrD	GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016043,GO:0016070,GO:0019219,GO:0019222,GO:0019439,GO:0022607,GO:0031323,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044464,GO:0046483,GO:0046700,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:1901360,GO:1901361,GO:1901575		ko:K18765					ko00000,ko03019				Bacteria	1MUQV@1224,1RN0Q@1236,3XMX0@561,COG2199@1,COG2199@2,COG2200@1,COG2200@2	NA|NA|NA	T	Serves as a specificity factor required for RNase E- mediated decay of the small global regulatory RNAs CsrB and CsrC, it is probably not a nuclease. Nor does its activity involve c-di- GMP, despite its domain composition. Positively modulates motility gene expression, is also required for curli expression
C1_04391	1006000.GKAS_00120	1.5e-189	668.7	Gammaproteobacteria	mreB	GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005856,GO:0005886,GO:0007049,GO:0008150,GO:0008360,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0032505,GO:0042802,GO:0043093,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051301,GO:0051302,GO:0051782,GO:0051983,GO:0065007,GO:0065008,GO:0071944		ko:K03569					ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1			Bacteria	1MUMW@1224,1RN82@1236,COG1077@1,COG1077@2	NA|NA|NA	D	rod shape-determining protein MreB
C1_04392	155864.EDL933_4471	1e-177	629.4	Escherichia	mreC	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007163,GO:0008150,GO:0008360,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0030428,GO:0031224,GO:0031226,GO:0042546,GO:0043621,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071554,GO:0071840,GO:0071944,GO:0071963		ko:K03570					ko00000,ko03036	9.B.157.1			Bacteria	1N8ZS@1224,1RMK4@1236,3XNFQ@561,COG1792@1,COG1792@2	NA|NA|NA	M	shape-determining protein MreC
C1_04393	155864.EDL933_4470	2.1e-82	311.6	Escherichia	mreD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008360,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944		ko:K03571					ko00000,ko03036	9.B.157.1			Bacteria	1RER7@1224,1S8VI@1236,3XPDW@561,COG2891@1,COG2891@2	NA|NA|NA	M	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C1_04394	199310.c4002	1.3e-102	379.0	Escherichia	maf	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0030312,GO:0036218,GO:0036221,GO:0042802,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0047429,GO:0071944	2.1.1.190	ko:K03215,ko:K06287					ko00000,ko01000,ko03009				Bacteria	1RH6H@1224,1S41D@1236,3XMC4@561,COG0424@1,COG0424@2	NA|NA|NA	D	UTP diphosphatase activity
C1_04395	155864.EDL933_4468	1.5e-275	954.9	Escherichia	rng	GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008996,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360		ko:K08301					ko00000,ko01000,ko03009,ko03019				Bacteria	1MV65@1224,1RMIW@1236,3XM8G@561,COG1530@1,COG1530@2	NA|NA|NA	J	Involved in the processing of the 5'-end of 16S rRNA. Could be involved in chromosome segregation and cell division. It may be one of the components of the cytoplasmic axial filaments bundles or merely regulate the formation of this structure
C1_04396	316407.85676038	0.0	2558.1	Escherichia	yhdP	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0042597,GO:0044425,GO:0044459,GO:0044464,GO:0071944											Bacteria	1MXWF@1224,1RNUK@1236,3XMN7@561,COG3164@1,COG3164@2	NA|NA|NA	S	Protein of unknown function
C1_04397	198214.SF3283	1.3e-268	931.8	Gammaproteobacteria	tldD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564		ko:K03568					ko00000,ko01002				Bacteria	1MUSK@1224,1RMA5@1236,COG0312@1,COG0312@2	NA|NA|NA	S	'responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase
C1_04398	199310.c3998	2.9e-173	614.4	Escherichia	aaeR	GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141		ko:K21698					ko00000,ko03000				Bacteria	1PTTR@1224,1RRTB@1236,3XP4Q@561,COG0583@1,COG0583@2	NA|NA|NA	K	Activates transcription of the aaeXAB operon
C1_04399	1114922.CIFAM_19_00390	4.3e-29	133.3	Citrobacter	aaeX			ko:K21695					ko00000	8.A.48			Bacteria	1N7N9@1224,1SCX3@1236,2DNQE@1,32YJX@2,3WYUM@544	NA|NA|NA	S	Protein of unknown function (DUF1656)
C1_04400	316407.85676034	4.1e-167	594.0	Escherichia	aaeA	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0015238,GO:0015546,GO:0015711,GO:0015849,GO:0015893,GO:0015906,GO:0016020,GO:0022857,GO:0033554,GO:0042221,GO:0042493,GO:0042886,GO:0042887,GO:0042891,GO:0042895,GO:0042908,GO:0042910,GO:0044464,GO:0045117,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:1901474,GO:1901682,GO:1902599		ko:K03543,ko:K15548,ko:K15549		M00701			ko00000,ko00002,ko02000	8.A.1.1,8.A.1.1.3,8.A.1.7.1			Bacteria	1MWG0@1224,1RPC8@1236,3XMB6@561,COG1566@1,COG1566@2	NA|NA|NA	V	P-hydroxybenzoic acid efflux pump subunit AaeA
C1_04401	198214.SF3280	0.0	1263.4	Gammaproteobacteria	aaeB	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0015711,GO:0015849,GO:0016020,GO:0044464,GO:0046942,GO:0051179,GO:0051234,GO:0071702,GO:0071944		ko:K03468					ko00000,ko02000	2.A.85.1.2			Bacteria	1MX9H@1224,1RPFA@1236,COG1289@1,COG1289@2	NA|NA|NA	U	Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell
C1_04402	155864.EDL933_4461	2.9e-44	184.1	Escherichia	yhcO			ko:K03623					ko00000				Bacteria	1MZ53@1224,1S8RD@1236,3XPUY@561,COG2732@1,COG2732@2	NA|NA|NA	K	Barstar (barnase inhibitor)
C1_04403	155864.EDL933_4460	2.5e-29	134.4	Escherichia	yhcN	GO:0000302,GO:0006950,GO:0006979,GO:0008150,GO:0009268,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0010447,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042710,GO:0044010,GO:0044011,GO:0044764,GO:0046677,GO:0050896,GO:0051703,GO:0051704,GO:0051716,GO:0070301,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071468,GO:0090605,GO:0090609,GO:0097237,GO:0104004,GO:1901700,GO:1901701											Bacteria	1N52F@1224,1S957@1236,2CAQ2@1,31NM5@2,3XPYP@561	NA|NA|NA	S	cellular response to acidic pH
C1_04404	155864.EDL933_4459	1.8e-78	298.5	Escherichia	argR	GO:0000820,GO:0000821,GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006259,GO:0006310,GO:0006355,GO:0006520,GO:0006521,GO:0006525,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009064,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016043,GO:0016597,GO:0019219,GO:0019222,GO:0019752,GO:0022607,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031329,GO:0031333,GO:0031334,GO:0031406,GO:0032991,GO:0032993,GO:0033238,GO:0033241,GO:0034214,GO:0034618,GO:0034641,GO:0036094,GO:0042150,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043254,GO:0043436,GO:0043565,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044212,GO:0044237,GO:0044238,GO:0044260,GO:0044281,GO:0044424,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051130,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051259,GO:0060255,GO:0062012,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0140110,GO:1900079,GO:1900081,GO:1901360,GO:1901363,GO:1901564,GO:1901605,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2000144,GO:2000282,GO:2001141		ko:K03402					ko00000,ko03000				Bacteria	1N2AF@1224,1RSF7@1236,3XN1P@561,COG1438@1,COG1438@2	NA|NA|NA	K	Regulates arginine biosynthesis genes
C1_04405	155864.EDL933_4458	2.1e-166	591.7	Escherichia	mdh	GO:0003674,GO:0003824,GO:0004470,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006099,GO:0006101,GO:0006108,GO:0006113,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009060,GO:0009061,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015980,GO:0016020,GO:0016052,GO:0016053,GO:0016310,GO:0016491,GO:0016614,GO:0016615,GO:0016999,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019898,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044425,GO:0044444,GO:0044464,GO:0045333,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072350,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000			iEcolC_1368.EcolC_0470	Bacteria	1MV57@1224,1RMAX@1236,3XMCI@561,COG0039@1,COG0039@2	NA|NA|NA	C	Catalyzes the reversible oxidation of malate to oxaloacetate
C1_04406	198214.SF3275	3.8e-193	680.6	Gammaproteobacteria	degS	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0009987,GO:0010033,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030163,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0033554,GO:0035966,GO:0035967,GO:0042221,GO:0042597,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051603,GO:0051716,GO:0051788,GO:0061077,GO:0070011,GO:0070887,GO:0071218,GO:0071310,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564,GO:1901565,GO:1901575	3.4.21.107	ko:K04691,ko:K04771,ko:K04772	ko01503,ko02020,map01503,map02020	M00728			ko00000,ko00001,ko00002,ko01000,ko01002,ko03110				Bacteria	1MU63@1224,1RN9T@1236,COG0265@1,COG0265@2	NA|NA|NA	M	Belongs to the peptidase S1C family
C1_04407	316407.85676027	1.7e-241	841.6	Escherichia	degQ	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030163,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051603,GO:0061077,GO:0070011,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564,GO:1901565,GO:1901575	1.3.1.74,3.4.21.107	ko:K04771,ko:K04772,ko:K08070	ko01503,ko02020,map01503,map02020	M00728			ko00000,ko00001,ko00002,ko01000,ko01002,ko03110				Bacteria	1MU63@1224,1RN9T@1236,3XP2Q@561,COG0265@1,COG0265@2	NA|NA|NA	M	DegQ could degrade transiently denatured and unfolded proteins which accumulate in the periplasm following stress conditions. DegQ is efficient with Val-Xaa and Ile-Xaa peptide bonds, suggesting a preference for a beta-branched side chain amino acids. Only unfolded proteins devoid of disulfide bonds appear capable to be cleaved, thereby preventing non-specific proteolysis of folded proteins. DegQ can substitute for the periplasmic protease DegP
C1_04408	155864.EDL933_4455	1.5e-65	255.4	Escherichia	yhcB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0071944		ko:K09908					ko00000				Bacteria	1RE90@1224,1S3S2@1236,3XPIB@561,COG3105@1,COG3105@2	NA|NA|NA	S	oxidoreductase activity
C1_04409	198214.SF3272	9.3e-214	749.2	Gammaproteobacteria	zapE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032153,GO:0044424,GO:0044464,GO:0051301		ko:K06916					ko00000,ko03036				Bacteria	1MUUW@1224,1RMTJ@1236,COG1485@1,COG1485@2	NA|NA|NA	D	Reduces the stability of FtsZ polymers in the presence of ATP
C1_04410	1440052.EAKF1_ch2715	4.5e-76	290.4	Escherichia	rplM	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0070180,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113		ko:K02871	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1RA11@1224,1S280@1236,3XP67@561,COG0102@1,COG0102@2	NA|NA|NA	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C1_04411	1005994.GTGU_03830	8.8e-63	246.1	Gammaproteobacteria	rpsI	GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02996	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1RD4A@1224,1S3Q7@1236,COG0103@1,COG0103@2	NA|NA|NA	J	Belongs to the universal ribosomal protein uS9 family
C1_04412	1440052.EAKF1_ch2717	5.4e-118	430.3	Escherichia	sspA	GO:0001000,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006950,GO:0008150,GO:0009605,GO:0009889,GO:0009891,GO:0009893,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0042594,GO:0043175,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070063,GO:0080090,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141		ko:K03599					ko00000,ko02000,ko03021	1.A.12.3.1			Bacteria	1MXJD@1224,1RP12@1236,3XM2Z@561,COG0625@1,COG0625@2	NA|NA|NA	K	Forms an equimolar complex with the RNA polymerase holoenzyme (RNAP) but not with the core enzyme
C1_04413	155864.EDL933_4450	4.5e-88	330.5	Escherichia	sspB	GO:0000502,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0009376,GO:0009893,GO:0009894,GO:0009896,GO:0010604,GO:0019222,GO:0019899,GO:0031597,GO:0032781,GO:0032991,GO:0042176,GO:0042802,GO:0042803,GO:0043085,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043462,GO:0044093,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0045732,GO:0046983,GO:0048518,GO:0050789,GO:0050790,GO:0051117,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051336,GO:0051345,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:0097159,GO:1901363,GO:1902494,GO:1904949,GO:1905368,GO:1905369,GO:1990904		ko:K03600,ko:K09985					ko00000,ko03021				Bacteria	1MZ2Q@1224,1S8WT@1236,3XMPC@561,COG2969@1,COG2969@2	NA|NA|NA	S	the ssrA degradation tag (AANDENYALAA) is added trans-translationally to proteins that are stalled on the ribosome, freeing the ribosome and targeting stalled peptides for degradation. SspB activates the ATPase activity of ClpX. Seems to act in concert with SspA in the regulation of several proteins during exponential and stationary-phase growth
C1_04414	316407.85676020	3.6e-236	823.9	Escherichia	dcuD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0008150,GO:0015711,GO:0015740,GO:0015849,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0051179,GO:0051234,GO:0071702,GO:0071944		ko:K03326					ko00000,ko02000	2.A.61.1			Bacteria	1MWBG@1224,1RQB2@1236,3XNN1@561,COG3069@1,COG3069@2	NA|NA|NA	P	Responsible for the transport of C4-dicarboxylates during anaerobic growth
C1_04415	316407.85676019	3.9e-142	510.8	Escherichia	nanR	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576		ko:K22104					ko00000,ko03000				Bacteria	1N6N0@1224,1RPZ0@1236,3XNGW@561,COG2186@1,COG2186@2	NA|NA|NA	K	Transcriptional repressor that controls expression of the genes required for the catabolism of sialic acids
C1_04416	155864.EDL933_4447	5.3e-164	583.6	Escherichia	nanA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006040,GO:0006054,GO:0006082,GO:0008150,GO:0008152,GO:0008747,GO:0009056,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016833,GO:0016999,GO:0017001,GO:0017144,GO:0019262,GO:0019752,GO:0042737,GO:0042802,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046348,GO:0046395,GO:0071704,GO:1901135,GO:1901136,GO:1901575	4.1.3.3,4.3.3.7	ko:K01639,ko:K01714	ko00261,ko00300,ko00520,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map00520,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R01811,R10147	RC00159,RC00600,RC03062,RC03063	ko00000,ko00001,ko00002,ko01000			iAF1260.b3225,iAPECO1_1312.APECO1_3218,iB21_1397.B21_03036,iBWG_1329.BWG_2926,iE2348C_1286.E2348C_3497,iEC042_1314.EC042_3509,iEC55989_1330.EC55989_3638,iECABU_c1320.ECABU_c36330,iECBD_1354.ECBD_0522,iECB_1328.ECB_03085,iECDH10B_1368.ECDH10B_3402,iECDH1ME8569_1439.ECDH1ME8569_3113,iECD_1391.ECD_03085,iECH74115_1262.ECH74115_4542,iECIAI1_1343.ECIAI1_3367,iECNA114_1301.ECNA114_3298,iECO103_1326.ECO103_3966,iECO26_1355.ECO26_4324,iECOK1_1307.ECOK1_3639,iECP_1309.ECP_3308,iECS88_1305.ECS88_3602,iECSF_1327.ECSF_3050,iECSP_1301.ECSP_4194,iECUMN_1333.ECUMN_3699,iECs_1301.ECs4098,iETEC_1333.ETEC_3486,iEcDH1_1363.EcDH1_0481,iEcE24377_1341.EcE24377A_3707,iEcHS_1320.EcHS_A3413,iEcolC_1368.EcolC_0481,iG2583_1286.G2583_3945,iJO1366.b3225,iJR904.b3225,iSDY_1059.SDY_3400,iSFV_1184.SFV_3250,iSF_1195.SF3261,iSFxv_1172.SFxv_3573,iSSON_1240.SSON_3366,iS_1188.S3478,iSbBS512_1146.SbBS512_E3551,iUMN146_1321.UM146_00280,iUTI89_1310.UTI89_C3655,iY75_1357.Y75_RS16725,iZ_1308.Z4583	Bacteria	1Q7AX@1224,1RRZG@1236,3XP47@561,COG0329@1,COG0329@2	NA|NA|NA	H	Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate
C1_04417	198214.SF3260	1.8e-281	974.5	Gammaproteobacteria	nanT	GO:0003674,GO:0005215,GO:0005342,GO:0005351,GO:0005402,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0008643,GO:0015075,GO:0015077,GO:0015078,GO:0015136,GO:0015144,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015672,GO:0015711,GO:0015739,GO:0015849,GO:0016020,GO:0022804,GO:0022857,GO:0022890,GO:0034219,GO:0034220,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:1901264,GO:1901505,GO:1902600,GO:1903825,GO:1905039		ko:K03290,ko:K08178					ko00000,ko02000	2.A.1.12		iECUMN_1333.ECUMN_3698	Bacteria	1MWKH@1224,1RZ3Z@1236,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
C1_04418	199310.c3977	8.7e-122	443.0	Escherichia	nanE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006040,GO:0006050,GO:0006051,GO:0006053,GO:0006054,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016853,GO:0016854,GO:0016857,GO:0016999,GO:0017001,GO:0017144,GO:0019262,GO:0019752,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046346,GO:0046348,GO:0046395,GO:0047465,GO:0071704,GO:1901135,GO:1901136,GO:1901575	2.7.1.60,5.1.3.9	ko:K01788,ko:K13967	ko00520,ko01100,map00520,map01100		R02087,R02705	RC00002,RC00017,RC00290	ko00000,ko00001,ko01000			iB21_1397.B21_03034,iECBD_1354.ECBD_0524,iECB_1328.ECB_03083,iECD_1391.ECD_03083,iEcHS_1320.EcHS_A3411,iEcolC_1368.EcolC_0483,iSFV_1184.SFV_3248,iSF_1195.SF3259,iSFxv_1172.SFxv_3571,iS_1188.S3476,iUTI89_1310.UTI89_C3653,ic_1306.c3977	Bacteria	1PRVW@1224,1RS59@1236,3XNV5@561,COG3010@1,COG3010@2	NA|NA|NA	G	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
C1_04419	469008.B21_03033	2.9e-154	551.2	Escherichia	nanK	GO:0003674,GO:0003824,GO:0005975,GO:0006040,GO:0006054,GO:0006082,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009384,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016999,GO:0017001,GO:0017144,GO:0019200,GO:0019262,GO:0019752,GO:0033554,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044281,GO:0044282,GO:0046348,GO:0046395,GO:0046835,GO:0050896,GO:0051716,GO:0071704,GO:1901135,GO:1901136,GO:1901575	2.7.1.2,2.7.1.60,5.1.3.9	ko:K00845,ko:K00885,ko:K13967	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786,R02087,R02705	RC00002,RC00017,RC00290	ko00000,ko00001,ko00002,ko01000			iE2348C_1286.E2348C_3494,iECO26_1355.ECO26_4321,iECSF_1327.ECSF_3047,iECs_1301.ECs4095,iSFV_1184.SFV_3247,iSFxv_1172.SFxv_3570,iZ_1308.Z4580	Bacteria	1Q78E@1224,1RRA2@1236,3XNS2@561,COG1940@1,COG1940@2	NA|NA|NA	F	Belongs to the ROK (NagC XylR) family. NanK subfamily
C1_04420	198214.SF3257	1.6e-82	312.0	Gammaproteobacteria	yhcH	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716		ko:K12112,ko:K19334	ko00052,ko00511,ko01100,map00052,map00511,map01100		R01678	RC00049	ko00000,ko00001,ko02048				Bacteria	1RCDU@1224,1S39H@1236,COG2731@1,COG2731@2	NA|NA|NA	G	cellular response to DNA damage stimulus
C1_04421	362663.ECP_3303	8.7e-212	742.7	Escherichia	yhcG												Bacteria	1NBWK@1224,1RY9R@1236,3XR0X@561,COG4804@1,COG4804@2	NA|NA|NA	S	nuclease activity
C1_04422	155864.EDL933_4441	7e-275	952.6	Escherichia	gltD	GO:0003674,GO:0003824,GO:0004355,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045181,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230		R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000			iEC042_1314.EC042_3503,iYL1228.KPN_03625	Bacteria	1MU2H@1224,1RMY7@1236,3XP5J@561,COG0493@1,COG0493@2	NA|NA|NA	C	glutamate synthase
C1_04423	469008.B21_03028	0.0	3025.0	Escherichia	gltB	GO:0003674,GO:0003824,GO:0004355,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045181,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230		R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000			iBWG_1329.BWG_2914,iECDH10B_1368.ECDH10B_3387,iECDH1ME8569_1439.EcDH1_0495,iEcDH1_1363.EcDH1_0495,iPC815.YPO3557	Bacteria	1MU7B@1224,1RN2W@1236,3XMUK@561,COG0067@1,COG0067@2,COG0069@1,COG0069@2,COG0070@1,COG0070@2	NA|NA|NA	E	glutamate synthase
C1_04424	155864.EDL933_4439	5.9e-182	643.3	Escherichia	yhcC	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464,GO:0048037,GO:0051536,GO:0051539,GO:0051540		ko:K07139					ko00000				Bacteria	1MUYF@1224,1RP94@1236,3XP7F@561,COG1242@1,COG1242@2	NA|NA|NA	S	4 iron, 4 sulfur cluster binding
C1_04425	198214.SF3250	0.0	1448.7	Gammaproteobacteria	arcB	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009927,GO:0009987,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031224,GO:0035556,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.7.13.3	ko:K07648	ko02020,ko02026,map02020,map02026	M00456			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Bacteria	1NC9X@1224,1SVEC@1236,COG0784@1,COG0784@2,COG2198@1,COG2198@2,COG5002@1,COG5002@2	NA|NA|NA	T	Histidine kinase
C1_04426	198214.SF3249	1.2e-115	422.5	Gammaproteobacteria	elbB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009893,GO:0009987,GO:0019216,GO:0019222,GO:0019747,GO:0031323,GO:0031325,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0045828,GO:0045834,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0065007,GO:0071704,GO:0080090,GO:1901576											Bacteria	1MW2K@1224,1RMDJ@1236,COG3155@1,COG3155@2	NA|NA|NA	Q	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C1_04427	316407.85676002	1.5e-132	478.8	Escherichia	mtgA	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008289,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031406,GO:0031975,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042277,GO:0042546,GO:0042597,GO:0043164,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071723,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681	2.4.1.129,3.4.16.4	ko:K03814,ko:K05365	ko00550,map00550		R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011		GT51	iSBO_1134.SBO_0138	Bacteria	1RDAQ@1224,1RMGB@1236,3XP9W@561,COG0744@1,COG0744@2	NA|NA|NA	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C1_04428	481805.EcolC_0493	8.2e-119	433.0	Escherichia													Bacteria	1RI1C@1224,1RNN5@1236,3XMM0@561,COG0515@1,COG0515@2	NA|NA|NA	KLT	PhoP regulatory network protein YrbL
C1_04429	198214.SF3246	2.3e-41	174.5	Gammaproteobacteria	ptsO	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006808,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0009401,GO:0009987,GO:0010033,GO:0010243,GO:0016310,GO:0016740,GO:0016772,GO:0019538,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0050789,GO:0050896,GO:0051179,GO:0051234,GO:0065007,GO:0071702,GO:0071704,GO:1901564,GO:1901698	2.7.1.121,2.7.1.202,2.7.3.9	ko:K02768,ko:K02784,ko:K05881,ko:K08483,ko:K08485,ko:K11183,ko:K11189,ko:K11201	ko00051,ko00561,ko01100,ko01120,ko02060,map00051,map00561,map01100,map01120,map02060	M00273,M00306	R01012,R03232	RC00015,RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1,8.A.7,8.A.8.1.1		e_coli_core.b2415,iAF1260.b2415,iB21_1397.B21_02276,iBWG_1329.BWG_2177,iE2348C_1286.E2348C_2601,iEC042_1314.EC042_2624,iEC55989_1330.EC55989_2705,iECABU_c1320.ECABU_c27360,iECBD_1354.ECBD_1266,iECB_1328.ECB_02315,iECDH10B_1368.ECDH10B_2580,iECDH1ME8569_1439.ECDH1ME8569_2349,iECDH1ME8569_1439.EcDH1_1246,iECD_1391.ECD_02315,iECED1_1282.ECED1_2859,iECH74115_1262.ECH74115_3646,iECIAI1_1343.ECIAI1_2473,iECIAI39_1322.ECIAI39_2561,iECNA114_1301.ECNA114_2492,iECO103_1326.ECO103_2934,iECO111_1330.ECO111_3145,iECO26_1355.ECO26_3468,iECOK1_1307.ECOK1_2732,iECP_1309.ECP_2439,iECS88_1305.ECS88_2605,iECSE_1348.ECSE_2706,iECSF_1327.ECSF_2279,iECSP_1301.ECSP_3363,iECUMN_1333.ECUMN_2737,iECW_1372.ECW_m2644,iECs_1301.ECs3287,iEKO11_1354.EKO11_1313,iETEC_1333.ETEC_2528,iEcDH1_1363.EcDH1_1246,iEcE24377_1341.EcE24377A_2702,iEcHS_1320.EcHS_A2550,iEcSMS35_1347.EcSMS35_2570,iEcolC_1368.EcolC_1263,iG2583_1286.G2583_2947,iJO1366.b2415,iJR904.b2415,iLF82_1304.LF82_1769,iNRG857_1313.NRG857_12110,iSBO_1134.SBO_2155,iSBO_1134.SBO_2439,iSDY_1059.SDY_2612,iSFV_1184.SFV_2467,iSF_1195.SF1201,iSF_1195.SF2470,iSFxv_1172.SFxv_2719,iSSON_1240.SSON_2504,iS_1188.S1285,iS_1188.S2616,iSbBS512_1146.SbBS512_E0794,iSbBS512_1146.SbBS512_E2765,iUMN146_1321.UM146_04545,iUMNK88_1353.UMNK88_3017,iUTI89_1310.UTI89_C2749,iWFL_1372.ECW_m2644,iY75_1357.Y75_RS12655,iZ_1308.Z3681,ic_1306.c2950	Bacteria	1N6RM@1224,1SCXX@1236,COG1925@1,COG1925@2	NA|NA|NA	G	Phosphotransferase System
C1_04430	155864.EDL933_4433	1.1e-158	565.8	Escherichia	rapZ	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363		ko:K06958					ko00000,ko03019				Bacteria	1MVX6@1224,1RNJX@1236,3XP0Y@561,COG1660@1,COG1660@2	NA|NA|NA	S	Modulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ. When glucosamine-6-phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ and targets it to cleavage by RNase E. Consequently, GlmZ is inactivated and unable to activate GlmS synthesis. Under low GlcN6P concentrations, RapZ is sequestered and inactivated by an other regulatory small RNA, GlmY, preventing GlmZ degradation and leading to synthesis of GlmS
C1_04431	198214.SF3244	5.7e-83	313.5	Gammaproteobacteria	ptsN	GO:0001932,GO:0001934,GO:0003674,GO:0003824,GO:0004857,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006810,GO:0008047,GO:0008150,GO:0008643,GO:0009401,GO:0009893,GO:0010033,GO:0010243,GO:0010562,GO:0010604,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0019207,GO:0019209,GO:0019220,GO:0019222,GO:0019887,GO:0022804,GO:0022857,GO:0022898,GO:0030234,GO:0030295,GO:0031323,GO:0031325,GO:0031399,GO:0031401,GO:0032147,GO:0032268,GO:0032270,GO:0032409,GO:0032412,GO:0032879,GO:0033674,GO:0034219,GO:0034762,GO:0034765,GO:0042221,GO:0042325,GO:0042327,GO:0043085,GO:0043086,GO:0043269,GO:0043549,GO:0044092,GO:0044093,GO:0044424,GO:0044444,GO:0044464,GO:0045859,GO:0045860,GO:0045937,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051049,GO:0051171,GO:0051173,GO:0051174,GO:0051179,GO:0051234,GO:0051246,GO:0051247,GO:0051338,GO:0051347,GO:0055085,GO:0060255,GO:0065007,GO:0065009,GO:0071702,GO:0071944,GO:0080090,GO:0090563,GO:0098772,GO:1901698	2.7.1.194,2.7.1.195,2.7.1.200,2.7.1.202,2.7.3.9	ko:K02768,ko:K02769,ko:K02770,ko:K02773,ko:K02806,ko:K02821,ko:K08483,ko:K11189,ko:K11198,ko:K11199,ko:K11200,ko:K11201	ko00051,ko00052,ko00053,ko01100,ko01120,ko02060,map00051,map00052,map00053,map01100,map01120,map02060	M00273,M00279,M00283,M00305,M00306,M00550	R03232,R05570,R07671,R11169	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1,4.A.2.1.3,4.A.5.1,4.A.7.1,8.A.7		iECIAI39_1322.ECIAI39_0923,iSbBS512_1146.SbBS512_E4725	Bacteria	1RD0E@1224,1S668@1236,COG1762@1,COG1762@2	NA|NA|NA	G	PTS IIA-like nitrogen-regulatory protein PtsN
C1_04432	155864.EDL933_4431	4.2e-46	190.3	Escherichia	hpf	GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0016020,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1990904,GO:2000112,GO:2000113		ko:K05808,ko:K05809					ko00000,ko03009				Bacteria	1MZHW@1224,1S8U1@1236,3XPXC@561,COG1544@1,COG1544@2	NA|NA|NA	J	During stationary phase, promotes and stabilizes dimerization of 70S ribosomes by the ribosome modulation factor (RMF), leading to the formation of inactive 100S ribosomes
C1_04433	155864.EDL933_4430	7.1e-235	819.7	Escherichia	rpoN	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141		ko:K03092	ko02020,ko05111,map02020,map05111				ko00000,ko00001,ko03021				Bacteria	1MW4V@1224,1RMY0@1236,3XN0B@561,COG1508@1,COG1508@2	NA|NA|NA	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C1_04434	1440052.EAKF1_ch2738c	1.4e-130	472.2	Escherichia	lptB	GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015399,GO:0015405,GO:0015437,GO:0015920,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0032991,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351		ko:K01990,ko:K06861	ko02010,map02010	M00254,M00320			ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1,3.A.1			Bacteria	1MU8M@1224,1RPW1@1236,3XNDU@561,COG1137@1,COG1137@2	NA|NA|NA	P	Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system
C1_04435	155864.EDL933_4428	6e-97	360.1	Escherichia	lptA	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0009279,GO:0010876,GO:0015920,GO:0016020,GO:0017089,GO:0019867,GO:0030288,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0042597,GO:0042802,GO:0044462,GO:0044464,GO:0046836,GO:0051179,GO:0051234,GO:0071702,GO:0071944,GO:1901264		ko:K09774					ko00000,ko02000	1.B.42.1		iB21_1397.B21_03016,iECBD_1354.ECBD_0542,iECB_1328.ECB_03065,iECD_1391.ECD_03065	Bacteria	1N776@1224,1RPM7@1236,3XNN8@561,COG1934@1,COG1934@2	NA|NA|NA	S	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C1_04436	155864.EDL933_4427	1.6e-100	372.1	Escherichia	lptC	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015920,GO:0016020,GO:0016021,GO:0017089,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0033036,GO:0042597,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0046836,GO:0051179,GO:0051234,GO:0071702,GO:0071944,GO:1901264		ko:K02040,ko:K11719	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222			ko00000,ko00001,ko00002,ko02000	1.B.42.1,3.A.1.7		iB21_1397.B21_03015,iECBD_1354.ECBD_0543,iECB_1328.ECB_03064,iECD_1391.ECD_03064	Bacteria	1RA1Y@1224,1SDZE@1236,3XN1W@561,COG3117@1,COG3117@2	NA|NA|NA	U	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA
C1_04437	198214.SF3238	1e-99	369.4	Gammaproteobacteria	kdsC	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008781,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016311,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016791,GO:0019143,GO:0033692,GO:0034637,GO:0034645,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0070567,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	3.1.3.45	ko:K03270	ko00540,ko01100,map00540,map01100	M00063	R03350	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005			iECO26_1355.ECO26_4302	Bacteria	1RH85@1224,1S6D0@1236,COG1778@1,COG1778@2	NA|NA|NA	S	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C1_04438	316407.85675991	6.7e-184	649.8	Escherichia	kdsD	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0005996,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0019146,GO:0019294,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0046364,GO:0046394,GO:0046400,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	5.3.1.13	ko:K02467,ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005			iAPECO1_1312.APECO1_3818,iECABU_c1320.ECABU_c29780,iECED1_1282.ECED1_3157,iECH74115_1262.ECH74115_4519,iECOK1_1307.ECOK1_3081,iECS88_1305.ECS88_2971,iECSP_1301.ECSP_4172,iECs_1301.ECs4076,iPC815.YPO3577,iSFV_1184.SFV_3227,iSFxv_1172.SFxv_3550,iUTI89_1310.UTI89_C3070,iYL1228.KPN_03607,iZ_1308.Z4560,ic_1306.c3262	Bacteria	1MUXD@1224,1RMT9@1236,3XMJQ@561,COG0517@1,COG0517@2,COG0794@1,COG0794@2	NA|NA|NA	M	Involved in the biosynthesis of 3-deoxy-D-manno- octulosonate (KDO), a unique 8-carbon sugar component of lipopolysaccharides (LPSs)
C1_04439	155864.EDL933_4424	1.3e-168	599.0	Escherichia	yrbG	GO:0003674,GO:0005215,GO:0005216,GO:0005261,GO:0005262,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006814,GO:0006816,GO:0006873,GO:0006874,GO:0006875,GO:0008150,GO:0008273,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015081,GO:0015085,GO:0015267,GO:0015291,GO:0015297,GO:0015298,GO:0015318,GO:0015368,GO:0015491,GO:0015672,GO:0016020,GO:0016021,GO:0019725,GO:0022803,GO:0022804,GO:0022821,GO:0022838,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030955,GO:0031224,GO:0031226,GO:0031402,GO:0031420,GO:0034220,GO:0035725,GO:0042592,GO:0043167,GO:0043169,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0070588,GO:0070838,GO:0071804,GO:0071805,GO:0071944,GO:0072503,GO:0072507,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099516		ko:K07301					ko00000,ko02000	2.A.19.5		iAPECO1_1312.APECO1_3239,iECABU_c1320.ECABU_c36110,iECNA114_1301.ECNA114_3275,iECOK1_1307.ECOK1_3617,iECS88_1305.ECS88_3578,iECSF_1327.ECSF_3028,iUMN146_1321.UM146_00400,iUTI89_1310.UTI89_C3632,ic_1306.c3956	Bacteria	1MU3R@1224,1RMRD@1236,3XMSD@561,COG0530@1,COG0530@2	NA|NA|NA	P	calcium:cation antiporter activity
C1_04440	155864.EDL933_4423	1.7e-148	531.9	Escherichia	mlaF	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0008144,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K02065	ko02010,map02010	M00210,M00669,M00670			ko00000,ko00001,ko00002,ko02000	3.A.1.27			Bacteria	1MUSD@1224,1RMCJ@1236,3XN7D@561,COG1127@1,COG1127@2	NA|NA|NA	P	Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Probably responsible for energy coupling to the transport system
C1_04441	155864.EDL933_4422	3e-134	484.6	Escherichia	mlaE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02066	ko02010,map02010	M00210,M00669,M00670			ko00000,ko00001,ko00002,ko02000	3.A.1.27			Bacteria	1MVPN@1224,1RM9H@1236,3XM51@561,COG0767@1,COG0767@2	NA|NA|NA	Q	Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane
C1_04442	155864.EDL933_4421	2.2e-96	358.2	Escherichia	mlaD	GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008289,GO:0016020,GO:0016021,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0042597,GO:0043167,GO:0043168,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K02067	ko02010,map02010	M00210,M00669,M00670			ko00000,ko00001,ko00002,ko02000	3.A.1.27			Bacteria	1NCUG@1224,1RQ0Y@1236,3XM4B@561,COG1463@1,COG1463@2	NA|NA|NA	Q	Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane
C1_04443	198214.SF3232	3e-113	414.5	Gammaproteobacteria	mlaC	GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0006869,GO:0008150,GO:0009987,GO:0010876,GO:0015711,GO:0015748,GO:0015914,GO:0016043,GO:0030288,GO:0030313,GO:0031975,GO:0033036,GO:0042597,GO:0044464,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071840,GO:0120009,GO:0120010		ko:K07323	ko02010,map02010	M00210			ko00000,ko00001,ko00002,ko02000	3.A.1.27.3			Bacteria	1NKFA@1224,1RNJW@1236,COG2854@1,COG2854@2	NA|NA|NA	Q	ABC-type transport system involved in resistance to organic solvents auxiliary component
C1_04444	155864.EDL933_4419	3e-47	194.1	Escherichia	mlaB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716		ko:K02066,ko:K04749,ko:K07122	ko02010,map02010	M00210,M00669,M00670			ko00000,ko00001,ko00002,ko02000,ko03021	3.A.1.27,3.A.1.27.3			Bacteria	1NGIE@1224,1SD2Q@1236,3XPX2@561,COG3113@1,COG3113@2	NA|NA|NA	S	Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane
C1_04445	155864.EDL933_4418	4.1e-43	180.3	Escherichia	yrbA	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051536,GO:0051537,GO:0051540		ko:K07390					ko00000,ko03029,ko03110				Bacteria	1N1WJ@1224,1SCAR@1236,3XPX8@561,COG5007@1,COG5007@2	NA|NA|NA	K	Belongs to the BolA IbaG family
C1_04446	198214.SF3229	4e-234	817.0	Gammaproteobacteria	murA	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008760,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016765,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100		R00660	RC00350	ko00000,ko00001,ko01000,ko01011				Bacteria	1MUH7@1224,1RN91@1236,COG0766@1,COG0766@2	NA|NA|NA	M	Belongs to the EPSP synthase family. MurA subfamily
C1_04447	155864.EDL933_4416	1.3e-47	195.3	Escherichia	sfsB	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576		ko:K07724					ko00000,ko03000				Bacteria	1N8W7@1224,1S966@1236,3XPV4@561,COG3423@1,COG3423@2	NA|NA|NA	K	This protein is involved in positive regulation of the metabolism of sugars
C1_04448	1440052.EAKF1_ch2752c	1.7e-179	635.2	Escherichia	ispB	GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009108,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663	2.5.1.30,2.5.1.90	ko:K00805,ko:K02523	ko00900,ko01110,map00900,map01110		R09247,R09248	RC00279	ko00000,ko00001,ko01000,ko01006			iYL1228.KPN_03597,ic_1306.c3945	Bacteria	1MUK6@1224,1RPR7@1236,3XP2Y@561,COG0142@1,COG0142@2	NA|NA|NA	H	Polyprenyl synthetase
C1_04449	1218086.BBNB01000015_gene2157	3.1e-50	204.1	Citrobacter	rplU	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02888	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1MZEW@1224,1S5VB@1236,3WYFF@544,COG0261@1,COG0261@2	NA|NA|NA	J	This protein binds to 23S rRNA in the presence of protein L20
C1_04450	1440052.EAKF1_ch2754	5.3e-40	169.9	Escherichia	rpmA	GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904		ko:K02899	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1MZGH@1224,1S8R2@1236,3XPWZ@561,COG0211@1,COG0211@2	NA|NA|NA	J	Ribosomal L27 protein
C1_04451	155864.EDL933_4412	8.3e-171	606.3	Escherichia	yhbE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1PGSE@1224,1RMZY@1236,3XP7W@561,COG0697@1,COG0697@2	NA|NA|NA	EG	EamA-like transporter family
C1_04452	198214.SF3223	2e-211	741.5	Gammaproteobacteria	obg	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0007059,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0022607,GO:0022611,GO:0022613,GO:0022618,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0042254,GO:0042255,GO:0043021,GO:0043023,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0065003,GO:0065007,GO:0070925,GO:0071826,GO:0071840,GO:0090069,GO:0090071,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K03979					ko00000,ko01000,ko03009				Bacteria	1MUGZ@1224,1RMFQ@1236,COG0536@1,COG0536@2	NA|NA|NA	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C1_04453	316407.85675976	5.4e-259	899.8	Escherichia	dacB	GO:0000003,GO:0000270,GO:0000910,GO:0003674,GO:0003824,GO:0004175,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0006022,GO:0006026,GO:0006027,GO:0006508,GO:0006807,GO:0007049,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009056,GO:0009057,GO:0009253,GO:0009254,GO:0009987,GO:0016043,GO:0016787,GO:0016998,GO:0017171,GO:0019538,GO:0019954,GO:0022402,GO:0022414,GO:0022603,GO:0022604,GO:0030203,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0032505,GO:0033218,GO:0033293,GO:0036094,GO:0042597,GO:0043093,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044464,GO:0045229,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051301,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0097159,GO:0140096,GO:1901135,GO:1901136,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901681	3.4.16.4	ko:K07259	ko00550,map00550				ko00000,ko00001,ko01000,ko01002,ko01011			iAPECO1_1312.APECO1_3250,iECOK1_1307.ECOK1_3603,iECS88_1305.ECS88_3564,iUMN146_1321.UM146_00470,iUTI89_1310.UTI89_C3615,iYL1228.KPN_03592	Bacteria	1MW40@1224,1RP8V@1236,3XMT9@561,COG2027@1,COG2027@2	NA|NA|NA	M	D-alanyl-D-alanine carboxypeptidase
C1_04454	155864.EDL933_4409	5.1e-81	307.0	Escherichia	greA	GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006354,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0030312,GO:0031323,GO:0031326,GO:0032774,GO:0032784,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141		ko:K03624					ko00000,ko03021				Bacteria	1RCXW@1224,1S3UP@1236,3XMI4@561,COG0782@1,COG0782@2	NA|NA|NA	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
C1_04455	155864.EDL933_4408	9.6e-46	189.1	Escherichia	yhbY	GO:0000027,GO:0000028,GO:0000966,GO:0000967,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0034470,GO:0034471,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0042274,GO:0043021,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1990275		ko:K07574					ko00000,ko03009				Bacteria	1N8K5@1224,1SDIM@1236,3XPVR@561,COG1534@1,COG1534@2	NA|NA|NA	J	preribosome binding
C1_04456	155864.EDL933_4407	5.2e-113	413.7	Escherichia	ftsJ	GO:0000027,GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008650,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022607,GO:0022613,GO:0022618,GO:0031167,GO:0032259,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043170,GO:0043412,GO:0043414,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.166	ko:K02427					ko00000,ko01000,ko03009				Bacteria	1MW1C@1224,1RN5M@1236,3XP2N@561,COG0293@1,COG0293@2	NA|NA|NA	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C1_04457	502347.ESCAB7627_0547	0.0	1266.1	Escherichia	ftsH	GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019222,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575		ko:K03798		M00742			ko00000,ko00002,ko01000,ko01002,ko03110				Bacteria	1MU6J@1224,1RME8@1236,3XMUM@561,COG0465@1,COG0465@2	NA|NA|NA	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C1_04458	155864.EDL933_4405	1.1e-153	549.3	Escherichia	folP	GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042221,GO:0042364,GO:0042398,GO:0042493,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046655,GO:0046656,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000			iECO103_1326.ECO103_3924,iPC815.YPO3501	Bacteria	1MUIR@1224,1RM8G@1236,3XM3V@561,COG0294@1,COG0294@2	NA|NA|NA	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C1_04459	316407.85675970	6.2e-249	866.3	Escherichia	glmM	GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006464,GO:0006468,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008966,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019538,GO:0034641,GO:0034654,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0046777,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130		R02060	RC00408	ko00000,ko00001,ko01000			iAF987.Gmet_1886,iLJ478.TM0184,iSB619.SA_RS11275,iSBO_1134.SBO_3206	Bacteria	1MU24@1224,1RMR2@1236,3XNUN@561,COG1109@1,COG1109@2	NA|NA|NA	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C1_04460	469008.B21_02991	1.1e-50	205.7	Escherichia	secG	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680		ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2			Bacteria	1N8MF@1224,1SD3P@1236,3XPS3@561,COG1314@1,COG1314@2	NA|NA|NA	U	Preprotein translocase band 1 subunit
C1_04462	469008.B21_02990	1.3e-309	1068.1	Escherichia	yhbX	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016772,GO:0016776,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046401,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.7.8.42,2.7.8.43	ko:K03760,ko:K12975,ko:K19353	ko00540,ko01503,map00540,map01503	M00722,M00723	R11204,R11205,R11555,R11556,R11557	RC00002,RC00017,RC00428	ko00000,ko00001,ko00002,ko01000,ko01005			iSSON_1240.SSON_3844	Bacteria	1MWS7@1224,1SYHV@1236,3XQZT@561,COG2194@1,COG2194@2	NA|NA|NA	S	sulfuric ester hydrolase activity
C1_04463	198214.SF3213	1.2e-260	905.2	Gammaproteobacteria	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147			iSBO_1134.SBO_3210,iSbBS512_1146.SbBS512_E3599	Bacteria	1MV0Y@1224,1RMEC@1236,COG0137@1,COG0137@2	NA|NA|NA	E	Belongs to the argininosuccinate synthase family. Type
C1_04465	316407.85675966	5.6e-77	293.5	Escherichia	rimP	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576		ko:K09748					ko00000,ko03009				Bacteria	1RDP2@1224,1S3Y7@1236,3XMQF@561,COG0779@1,COG0779@2	NA|NA|NA	J	Required for maturation of 30S ribosomal subunits
C1_04466	155864.EDL933_4398	1.1e-273	948.7	Escherichia	nusA	GO:0001000,GO:0001121,GO:0001125,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141		ko:K02600					ko00000,ko03009,ko03021				Bacteria	1MWT7@1224,1RNQS@1236,3XP77@561,COG0195@1,COG0195@2	NA|NA|NA	K	Participates in both transcription termination and antitermination
C1_04467	155864.EDL933_4397	0.0	1451.4	Escherichia	infB	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034645,GO:0036094,GO:0043021,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576		ko:K02519					ko00000,ko03012,ko03029				Bacteria	1MV26@1224,1RM9X@1236,3XMNK@561,COG0532@1,COG0532@2	NA|NA|NA	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C1_04468	155864.EDL933_4396	2.5e-65	254.6	Escherichia	rbfA	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0030490,GO:0033554,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043021,GO:0043024,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071840,GO:0090304,GO:1901360		ko:K02834					ko00000,ko03009				Bacteria	1MZPE@1224,1S9AF@1236,3XPJJ@561,COG0858@1,COG0858@2	NA|NA|NA	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C1_04469	155864.EDL933_4395	3.2e-175	620.9	Escherichia	truB	GO:0000049,GO:0001522,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0031119,GO:0034337,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990481	5.4.99.25	ko:K03177					ko00000,ko01000,ko03016				Bacteria	1MV0N@1224,1RMKP@1236,3XME1@561,COG0130@1,COG0130@2	NA|NA|NA	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C1_04470	198214.SF3206	3.2e-40	170.6	Gammaproteobacteria	rpsO	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006378,GO:0006396,GO:0006397,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016071,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031123,GO:0031124,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043631,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02956	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Bacteria	1MZ2W@1224,1S8U6@1236,COG0184@1,COG0184@2	NA|NA|NA	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C1_04471	155864.EDL933_4393	0.0	1351.7	Escherichia	pnp	GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019				Bacteria	1MVB9@1224,1RNBF@1236,3XN31@561,COG1185@1,COG1185@2	NA|NA|NA	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
C1_04472	155864.EDL933_4392	9e-164	582.8	Escherichia	nlpI	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009987,GO:0016020,GO:0030674,GO:0044464,GO:0051301,GO:0060090,GO:0071944		ko:K05803					ko00000				Bacteria	1N02Y@1224,1RP8P@1236,3XNGQ@561,COG4785@1,COG4785@2	NA|NA|NA	D	May be involved in cell division. May play a role in bacterial septation or regulation of cell wall degradation during cell division
C1_04473	155864.EDL933_4391	5.8e-309	1066.2	Escherichia	deaD	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003724,GO:0003725,GO:0003727,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006417,GO:0006725,GO:0006807,GO:0006950,GO:0006996,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009987,GO:0010468,GO:0010501,GO:0010556,GO:0010557,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019439,GO:0022607,GO:0022613,GO:0022618,GO:0030312,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031330,GO:0032268,GO:0032270,GO:0033554,GO:0033592,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034655,GO:0042254,GO:0042255,GO:0042273,GO:0042623,GO:0043170,GO:0043487,GO:0043488,GO:0043489,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045934,GO:0046483,GO:0046700,GO:0048255,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051247,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0061013,GO:0065003,GO:0065007,GO:0065008,GO:0070035,GO:0070417,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097617,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902369,GO:1902373,GO:1903311,GO:1903312,GO:2000112	3.6.4.13	ko:K05591,ko:K05592	ko03018,map03018				ko00000,ko00001,ko01000,ko03009,ko03019				Bacteria	1MU49@1224,1RMWA@1236,3XNGY@561,COG0513@1,COG0513@2	NA|NA|NA	F	DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation
C1_04474	481805.EcolC_0537	1.8e-226	791.6	Escherichia	mtr	GO:0003333,GO:0003674,GO:0005215,GO:0005300,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015179,GO:0015196,GO:0015238,GO:0015291,GO:0015293,GO:0015318,GO:0015711,GO:0015801,GO:0015807,GO:0015827,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903825,GO:1905039		ko:K03834,ko:K03835,ko:K03836,ko:K03837,ko:K03838					ko00000,ko02000	2.A.42.1.1,2.A.42.1.2,2.A.42.1.3,2.A.42.2.1,2.A.42.2.2		iAPECO1_1312.APECO1_3308,iE2348C_1286.E2348C_3406,iEC55989_1330.EC55989_3533,iEC55989_1330.EC55989_3581,iECABU_c1320.ECABU_c35330,iECED1_1282.ECED1_3781,iECIAI1_1343.ECIAI1_3265,iECNA114_1301.ECNA114_4343,iECO103_1326.ECO103_3863,iECO103_1326.ECO103_3910,iECO111_1330.ECO111_3985,iECO26_1355.ECO26_4221,iECO26_1355.ECO26_4267,iECOK1_1307.ECOK1_3543,iECP_1309.ECP_3209,iECSE_1348.ECSE_3400,iECSE_1348.ECSE_3447,iECSF_1327.ECSF_2956,iECUMN_1333.ECUMN_2202,iECW_1372.ECW_m3385,iEKO11_1354.EKO11_0601,iEcE24377_1341.EcE24377A_3643,iLF82_1304.LF82_2232,iNRG857_1313.NRG857_15495,iSBO_1134.SBO_2981,iSDY_1059.SDY_3013,iSFV_1184.SFV_3804,iSFxv_1172.SFxv_4080,iSSON_1240.SSON_3307,iS_1188.S4018,iSbBS512_1146.SbBS512_E3241,iUMN146_1321.UM146_00750,iUTI89_1310.UTI89_C3551,iWFL_1372.ECW_m3385,ic_1306.c3874	Bacteria	1MWGI@1224,1RMME@1236,3XMR8@561,COG0814@1,COG0814@2	NA|NA|NA	E	Tryptophan-specific transport protein
C1_04475	199310.c3913	1.7e-190	671.8	Escherichia	yhbW	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Bacteria	1MVF0@1224,1RMCE@1236,3XM8W@561,COG2141@1,COG2141@2	NA|NA|NA	C	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
C1_04476	155864.EDL933_4387	7.8e-168	596.3	Escherichia	yhbV												Bacteria	1MWFW@1224,1RMWM@1236,3XMXE@561,COG0826@1,COG0826@2	NA|NA|NA	O	peptidase activity
C1_04477	481805.EcolC_0540	1.4e-189	668.7	Escherichia	yhbU			ko:K08303	ko05120,map05120				ko00000,ko00001,ko01000,ko01002				Bacteria	1MUQG@1224,1RP6X@1236,3XN96@561,COG0826@1,COG0826@2	NA|NA|NA	O	peptidase activity
C1_04478	155864.EDL933_4384	1.8e-90	338.6	Escherichia	yhbT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K08303	ko05120,map05120				ko00000,ko00001,ko01000,ko01002				Bacteria	1RB7T@1224,1RMJD@1236,3XMBQ@561,COG3154@1,COG3154@2	NA|NA|NA	I	SCP-2 sterol transfer family
C1_04479	155864.EDL933_4383	2.6e-91	341.3	Escherichia	yhbS	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006473,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564		ko:K03824					ko00000,ko01000				Bacteria	1RA42@1224,1S2G0@1236,3XP7J@561,COG3153@1,COG3153@2	NA|NA|NA	S	transferase activity, transferring acyl groups
C1_04480	481805.EcolC_0543	2e-49	201.4	Escherichia	yhbQ	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360		ko:K07461					ko00000				Bacteria	1N6PA@1224,1SCBH@1236,3XPY2@561,COG2827@1,COG2827@2	NA|NA|NA	L	Belongs to the UPF0213 family
C1_04481	198214.SF3195	2.2e-78	298.1	Gammaproteobacteria	yhbP	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K09979					ko00000				Bacteria	1RH76@1224,1S6F1@1236,COG3787@1,COG3787@2	NA|NA|NA	S	Belongs to the UPF0306 family
C1_04482	155864.EDL933_4380	1.7e-90	338.6	Escherichia	yfkM	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006089,GO:0006139,GO:0006259,GO:0006281,GO:0006464,GO:0006517,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009100,GO:0009266,GO:0009268,GO:0009314,GO:0009408,GO:0009411,GO:0009416,GO:0009438,GO:0009628,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019172,GO:0019249,GO:0019538,GO:0019752,GO:0030091,GO:0032787,GO:0033554,GO:0034641,GO:0036211,GO:0036524,GO:0036525,GO:0042180,GO:0042182,GO:0042802,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0046394,GO:0046483,GO:0050896,GO:0051596,GO:0051716,GO:0061727,GO:0071704,GO:0072330,GO:0090304,GO:0140096,GO:1901135,GO:1901360,GO:1901564,GO:1901575,GO:1901576,GO:1901615,GO:1901617	3.5.1.124,4.2.1.130	ko:K03152,ko:K05520,ko:K05523	ko00620,ko01120,map00620,map01120		R09796	RC02658	ko00000,ko00001,ko01000,ko01002				Bacteria	1MY0C@1224,1S3SC@1236,3XN80@561,COG0693@1,COG0693@2	NA|NA|NA	S	Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Is able to repair glycated serum albumin, collagen, glyceraldehyde-3-phosphate dehydrogenase, and fructose biphosphate aldolase. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage. Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair. In vitro, prevents acrylamide formation in asparagine glyoxal and asparagine sugar mixtures at 55 degrees Celsius, likely by degrading asparagine glyoxal Maillard adducts formed at high temperatures. Also displays an apparent glyoxalase activity that in fact reflects its deglycase activity. Is a general stress protein
C1_04483	469008.B21_02970	3.3e-115	421.0	Escherichia	yraR												Bacteria	1MZG7@1224,1S39N@1236,3XNI7@561,COG0702@1,COG0702@2	NA|NA|NA	GM	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C1_04484	198214.SF3192	2.3e-190	671.4	Gammaproteobacteria	yraQ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K07089					ko00000				Bacteria	1MUN8@1224,1RR9N@1236,COG0701@1,COG0701@2	NA|NA|NA	S	permease
C1_04485	155864.EDL933_4377	3.7e-94	350.9	Escherichia	yraP	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0032153,GO:0044462,GO:0044464,GO:0071944											Bacteria	1MUZ2@1224,1RY2B@1236,3XNV6@561,COG2823@1,COG2823@2	NA|NA|NA	S	BON domain
C1_04486	1440052.EAKF1_ch2788c	3.1e-104	384.4	Escherichia	gmhA	GO:0003674,GO:0005488,GO:0005515,GO:0006275,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010556,GO:0010557,GO:0010604,GO:0019219,GO:0019222,GO:0030174,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032298,GO:0042802,GO:0045740,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051052,GO:0051054,GO:0051171,GO:0051173,GO:0060255,GO:0065007,GO:0080090,GO:0090329,GO:2000105,GO:2000112	2.7.1.167,2.7.1.33,2.7.7.70,5.3.1.28	ko:K03271,ko:K03272,ko:K03525,ko:K12961	ko00540,ko00770,ko01100,map00540,map00770,map01100	M00064,M00120	R02971,R03018,R04391,R05644,R05645,R05646,R09768,R09769	RC00002,RC00017,RC00078,RC00434	ko00000,ko00001,ko00002,ko01000,ko01005,ko03036				Bacteria	1NJ8X@1224,1RS1Y@1236,3XMII@561,COG0279@1,COG0279@2	NA|NA|NA	J	Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein
C1_04487	155864.EDL933_4375	2.2e-69	268.1	Escherichia	yraN			ko:K07460					ko00000				Bacteria	1N6VN@1224,1SC8A@1236,3XPNC@561,COG0792@1,COG0792@2	NA|NA|NA	L	Belongs to the UPF0102 family
C1_04488	155864.EDL933_4374	0.0	1273.5	Escherichia	lpoA	GO:0000270,GO:0003674,GO:0005575,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0030203,GO:0030234,GO:0030312,GO:0030313,GO:0031241,GO:0031975,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044462,GO:0044464,GO:0050790,GO:0065007,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0098552,GO:0098772,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576		ko:K07121					ko00000				Bacteria	1MUHR@1224,1RXX4@1236,3XMC3@561,COG3107@1,COG3107@2	NA|NA|NA	M	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a)
C1_04489	481805.EcolC_0552	2.6e-155	554.7	Escherichia	rsmI	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.198	ko:K07056					ko00000,ko01000,ko03009				Bacteria	1MU0E@1224,1RM7U@1236,3XP22@561,COG0313@1,COG0313@2	NA|NA|NA	J	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C1_04490	316407.85675941	1.8e-201	708.4	Gammaproteobacteria	yraK	GO:0007155,GO:0008150,GO:0009987,GO:0022610,GO:0031589,GO:0042710,GO:0043708,GO:0043709,GO:0044010,GO:0044764,GO:0051704,GO:0090605,GO:0090609											Bacteria	1R6S6@1224,1S0U1@1236,COG3539@1,COG3539@2	NA|NA|NA	NU	Part of the yraHIJK fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim operon
C1_04491	481805.EcolC_0554	0.0	1677.5	Escherichia	yraJ	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0006950,GO:0006974,GO:0008150,GO:0009279,GO:0009297,GO:0009987,GO:0015267,GO:0015288,GO:0015473,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0022803,GO:0022829,GO:0022857,GO:0030030,GO:0030031,GO:0030312,GO:0030313,GO:0031975,GO:0033554,GO:0043711,GO:0044085,GO:0044462,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071840,GO:0071944		ko:K07347,ko:K07354	ko05133,map05133				ko00000,ko00001,ko02000,ko02035,ko02044	1.B.11.3			Bacteria	1MUHE@1224,1RMPU@1236,3XQDY@561,COG3188@1,COG3188@2	NA|NA|NA	NU	Part of the yraHIJK fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim operon. Probably involved in the export and assembly of fimbrial subunits across the outer membrane
C1_04492	316407.85675939	3.4e-126	457.6	Escherichia	yraI	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006457,GO:0006950,GO:0006974,GO:0007155,GO:0008150,GO:0009987,GO:0016043,GO:0022610,GO:0030030,GO:0030288,GO:0030313,GO:0031975,GO:0033554,GO:0042597,GO:0043711,GO:0044183,GO:0044464,GO:0050896,GO:0051716,GO:0061077,GO:0071840		ko:K07346,ko:K07353,ko:K15540					ko00000,ko02035,ko02044,ko03110				Bacteria	1PJPH@1224,1RYC4@1236,3XR1M@561,COG3121@1,COG3121@2	NA|NA|NA	M	Part of the yraHIJK fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim operon
C1_04493	155864.EDL933_4366	4.1e-104	384.0	Escherichia	yraH	GO:0007155,GO:0008150,GO:0022610		ko:K07345	ko05133,map05133				ko00000,ko00001,ko02035,ko02044				Bacteria	1N34A@1224,1SBGF@1236,3XRDH@561,COG3539@1,COG3539@2	NA|NA|NA	NU	Part of the yraHIJK fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim operon
C1_04494	198214.SF3177	2.2e-128	464.9	Gammaproteobacteria	nagB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016853,GO:0016860,GO:0016861,GO:0043877,GO:0044424,GO:0044444,GO:0044464	3.1.1.31,3.5.99.6	ko:K01057,ko:K02080,ko:K02564	ko00030,ko00052,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00052,map00520,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R00765,R02035,R08365	RC00163,RC00537	ko00000,ko00001,ko00002,ko01000			iB21_1397.B21_02959,iECB_1328.ECB_03008,iECD_1391.ECD_03008,iECNA114_1301.ECNA114_3225,iECSF_1327.ECSF_2979,iZ_1308.Z0825	Bacteria	1R8UH@1224,1RY0A@1236,COG0363@1,COG0363@2	NA|NA|NA	G	glucosamine-6-phosphate deaminase
C1_04495	155864.EDL933_4363	1.9e-141	508.4	Escherichia	agaD	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034219,GO:0044425,GO:0044459,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944		ko:K02747,ko:K02796,ko:K02815,ko:K10986	ko00051,ko00052,ko00520,ko01100,ko02060,map00051,map00052,map00520,map01100,map02060	M00276,M00277,M00278,M00287	R02630,R04076,R08366,R08367	RC00017,RC01069,RC03206	ko00000,ko00001,ko00002,ko02000	4.A.6.1,4.A.6.1.3,4.A.6.1.4,4.A.6.1.5		iECO103_1326.ECO103_3880,iECO111_1330.ECO103_3880,iECP_1309.ECP_1762,iUTI89_1310.UTI89_C3571,ic_1306.c3897	Bacteria	1R44X@1224,1RZ59@1236,3XMX9@561,COG3716@1,COG3716@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in N-acetylgalactosamine transport
C1_04496	316407.85675935	5.2e-142	510.4	Escherichia	agaC	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034219,GO:0044425,GO:0044459,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944		ko:K10985	ko00052,ko02060,map00052,map02060	M00287	R08367	RC00017,RC03206	ko00000,ko00001,ko00002,ko02000	4.A.6.1.5			Bacteria	1R5G0@1224,1RZTN@1236,3XPEE@561,COG3715@1,COG3715@2	NA|NA|NA	G	PTS system N-acetylgalactosamine-specific
C1_04497	469008.B21_02956	2.5e-83	314.7	Escherichia	agaB		2.7.1.191	ko:K02745,ko:K02794,ko:K10984	ko00051,ko00052,ko00520,ko01100,ko02060,map00051,map00052,map00520,map01100,map02060	M00276,M00277,M00287	R02630,R08366,R08367	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.6.1,4.A.6.1.4,4.A.6.1.5		iB21_1397.B21_02956,iEC55989_1330.EC55989_3558,iECBD_1354.ECBD_0602,iECB_1328.ECB_03005,iECD_1391.ECD_03005,iECH74115_1262.ECH74115_4447,iECIAI1_1343.ECIAI1_3288,iECIAI39_1322.ECIAI39_3639,iECO103_1326.ECO103_3885,iECO111_1330.ECO111_3962,iECO26_1355.ECO26_4243,iECSE_1348.ECSE_3424,iECSP_1301.ECSP_4104,iECW_1372.ECW_m3408,iEKO11_1354.EKO11_0579,iEcE24377_1341.EcE24377A_3620,iEcSMS35_1347.EcSMS35_3437,iEcolC_1368.EcolC_0560,iUMNK88_1353.UMNK88_3897,iWFL_1372.ECW_m3408	Bacteria	1R4ES@1224,1RWA2@1236,3XMC9@561,COG3444@1,COG3444@2	NA|NA|NA	G	IIB component
C1_04498	155864.EDL933_4360	1.4e-158	565.5	Escherichia	kbaY	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008270,GO:0009025,GO:0009987,GO:0016043,GO:0016829,GO:0016830,GO:0016832,GO:0022607,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071840	4.1.2.40	ko:K08302	ko00052,ko01100,map00052,map01100		R01069	RC00438,RC00439	ko00000,ko00001,ko01000			iAF1260.b3137,iAPECO1_1312.APECO1_3290,iB21_1397.B21_02955,iBWG_1329.BWG_2841,iEC042_1314.EC042_3431,iEC55989_1330.EC55989_3557,iECABU_c1320.ECABU_c35530,iECBD_1354.ECBD_0603,iECB_1328.ECB_03004,iECDH10B_1368.ECDH10B_3310,iECDH1ME8569_1439.ECDH1ME8569_3028,iECD_1391.ECD_03004,iECED1_1282.ECED1_3801,iECH74115_1262.ECH74115_4454,iECIAI1_1343.ECIAI1_3287,iECO103_1326.ECO103_3884,iECO111_1330.ECO111_3961,iECO26_1355.ECO26_4242,iECOK1_1307.ECOK1_3561,iECP_1309.ECP_3229,iECS88_1305.ECS88_3525,iECSE_1348.ECSE_3423,iECSP_1301.ECSP_4111,iECW_1372.ECW_m3407,iECs_1301.ECs4017,iEKO11_1354.EKO11_0580,iETEC_1333.ETEC_3404,iEcDH1_1363.EcDH1_0568,iEcE24377_1341.EcE24377A_3619,iEcHS_1320.EcHS_A3329,iEcolC_1368.EcolC_0561,iG2583_1286.G2583_2628,iG2583_1286.G2583_3861,iJO1366.b3137,iJR904.b3137,iLF82_1304.LF82_1138,iNRG857_1313.NRG857_15590,iUMN146_1321.UM146_00665,iUMNK88_1353.UMNK88_3896,iUTI89_1310.UTI89_C3568,iWFL_1372.ECW_m3407,iY75_1357.Y75_RS16275,iZ_1308.Z4491,ic_1306.c3894	Bacteria	1MURX@1224,1RQUC@1236,3XPA4@561,COG0191@1,COG0191@2	NA|NA|NA	F	which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6- bisphosphate (TBP). Requires
C1_04499	469008.B21_02954	1.6e-221	775.0	Escherichia	agaS	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006040,GO:0006044,GO:0006046,GO:0006810,GO:0008150,GO:0008152,GO:0008448,GO:0008643,GO:0009056,GO:0009401,GO:0015144,GO:0016020,GO:0016021,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0022857,GO:0031224,GO:0031226,GO:0034219,GO:0044425,GO:0044459,GO:0044464,GO:0046348,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704,GO:0071944,GO:1901071,GO:1901072,GO:1901135,GO:1901136,GO:1901575		ko:K02082					ko00000,ko01000				Bacteria	1NICK@1224,1RRU0@1236,3XPES@561,COG2222@1,COG2222@2	NA|NA|NA	G	Catalyzes the isomerization-deamination of galactosamine 6-phosphate to form tagatofuranose 6-phosphate and ammonium ion
C1_04500	481805.EcolC_0563	5.3e-217	760.0	Escherichia	agaA	GO:0003674,GO:0003824,GO:0006040,GO:0006044,GO:0006046,GO:0008150,GO:0008152,GO:0008448,GO:0009056,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0046348,GO:0071704,GO:1901071,GO:1901072,GO:1901135,GO:1901136,GO:1901575	3.5.1.25	ko:K02079	ko00052,map00052		R05168	RC00166,RC00300	ko00000,ko00001,ko01000			iECBD_1354.ECBD_0605,iECB_1328.ECB_03002,iECD_1391.ECD_03002,iECO103_1326.ECO103_3882,iECO111_1330.ECO103_3882	Bacteria	1MW8Y@1224,1RMRV@1236,3XQ91@561,COG1820@1,COG1820@2	NA|NA|NA	G	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C1_04501	1440052.EAKF1_ch2803c	2.2e-75	288.1	Escherichia	agaF			ko:K02744	ko00052,ko02060,map00052,map02060	M00277,M00287	R08366,R08367	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.6.1.4,4.A.6.1.5		iECO111_1330.ECO111_3958,iECO26_1355.ECO26_4239,iECP_1309.ECP_3226,iSF_1195.SF3171,iSFxv_1172.SFxv_3481,iS_1188.S3386	Bacteria	1Q8RH@1224,1S2UG@1236,3XM6B@561,COG2893@1,COG2893@2	NA|NA|NA	G	PTS system fructose IIA component
C1_04502	1440052.EAKF1_ch2804c	1.1e-156	559.3	Escherichia	agaD			ko:K02747,ko:K02796,ko:K02815,ko:K10986,ko:K17467	ko00030,ko00051,ko00052,ko00520,ko01100,ko01120,ko02060,map00030,map00051,map00052,map00520,map01100,map01120,map02060	M00276,M00277,M00278,M00287,M00610	R02630,R04076,R08366,R08367,R10407	RC00017,RC01069,RC03206	ko00000,ko00001,ko00002,ko02000	4.A.6.1,4.A.6.1.17,4.A.6.1.3,4.A.6.1.4,4.A.6.1.5		iECIAI1_1343.ECIAI1_1888,iECO103_1326.ECO103_3880,iECO111_1330.ECO103_3880,iSBO_1134.SBO_1231,iSF_1195.SF1409,iSFxv_1172.SFxv_1596,iS_1188.S1524,iUTI89_1310.UTI89_C3571,ic_1306.c3897	Bacteria	1N45J@1224,1RSNE@1236,3XQRF@561,COG3716@1,COG3716@2	NA|NA|NA	G	PTS system mannose/fructose/sorbose family IID component
C1_04503	155864.EDL933_4354	3.8e-134	484.2	Escherichia	agaC			ko:K02746	ko00052,ko02060,map00052,map02060	M00277	R08366	RC00017	ko00000,ko00001,ko00002,ko02000	4.A.6.1.4		ic_1306.c3889	Bacteria	1NBYA@1224,1RQ1Z@1236,3XNP9@561,COG3715@1,COG3715@2	NA|NA|NA	G	PTS system sorbose-specific iic component
C1_04504	198214.SF3168	1.1e-83	315.8	Gammaproteobacteria	agaV		2.7.1.191	ko:K02745,ko:K02794	ko00051,ko00052,ko00520,ko01100,ko02060,map00051,map00052,map00520,map01100,map02060	M00276,M00277	R02630,R08366	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.6.1,4.A.6.1.4		iECH74115_1262.ECH74115_4447,iECSP_1301.ECSP_4104	Bacteria	1R4ES@1224,1RQ2P@1236,COG3444@1,COG3444@2	NA|NA|NA	G	pts system
C1_04505	316407.85675929	1.9e-247	861.3	Escherichia	kbaZ	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034219,GO:0044425,GO:0044459,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944	5.1.3.40	ko:K16371,ko:K21622	ko00052,ko01100,map00052,map01100		R01069,R11623	RC00438,RC00439	ko00000,ko00001,ko01000			iECIAI1_1343.ECIAI1_3280,iECO111_1330.ECO111_2811,iECO26_1355.ECO26_3004	Bacteria	1MW3Q@1224,1RQAU@1236,3XNDM@561,COG4573@1,COG4573@2	NA|NA|NA	G	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
C1_04507	592316.Pat9b_4039	7.7e-72	276.9	Pantoea				ko:K03496					ko00000,ko03036,ko04812				Bacteria	1QGKJ@1224,1TE11@1236,3W2IZ@53335,COG1192@1,COG1192@2	NA|NA|NA	D	ATPase MipZ
C1_04508	155864.EDL933_p0060	9.2e-128	463.0	Escherichia				ko:K04763,ko:K07357					ko00000,ko03036				Bacteria	1R8ME@1224,1RZMH@1236,3XPF5@561,COG0582@1,COG0582@2	NA|NA|NA	L	Phage integrase family
C1_04509	396595.TK90_2739	2.4e-42	178.3	Gammaproteobacteria													Bacteria	1NXAM@1224,1SW20@1236,2FAEB@1,342NM@2	NA|NA|NA		
C1_04511	573.JG24_01590	7.2e-21	106.3	Gammaproteobacteria													Bacteria	1NZ97@1224,1SQ06@1236,2ET1W@1,3431J@2	NA|NA|NA		
C1_04512	1216966.BAUC01000040_gene2829	9.8e-74	283.1	Gammaproteobacteria													Bacteria	1PH0Z@1224,1RZGV@1236,28JS6@1,2Z9HQ@2	NA|NA|NA		
C1_04513	1440052.EAKF1_ch3773	2.2e-175	621.7	Escherichia	ompC	GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0006869,GO:0006950,GO:0006974,GO:0008150,GO:0009279,GO:0009987,GO:0010876,GO:0015711,GO:0015748,GO:0015914,GO:0016020,GO:0016021,GO:0019867,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031975,GO:0033036,GO:0033554,GO:0044425,GO:0044462,GO:0044464,GO:0045203,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0071702,GO:0071944		ko:K09475	ko01501,ko02020,map01501,map02020				ko00000,ko00001,ko02000	1.B.1.1.3		iEC042_1314.EC042_2456,iUMNK88_1353.UMNK88_2764	Bacteria	1MVRY@1224,1RNBS@1236,3XPDX@561,COG3203@1,COG3203@2	NA|NA|NA	M	Forms pores that allow passive diffusion of small molecules across the outer membrane
C1_04514	1440052.EAKF1_ch0901c	2.3e-75	288.9	Escherichia	appY	GO:0003674,GO:0003700,GO:0006355,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009314,GO:0009605,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010165,GO:0010212,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016036,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042594,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141		ko:K03755,ko:K07780,ko:K11920,ko:K21905,ko:K21906	ko02020,map02020				ko00000,ko00001,ko03000				Bacteria	1Q19X@1224,1RPD4@1236,3XQUJ@561,COG2207@1,COG2207@2	NA|NA|NA	K	Helix-turn-helix domain
C1_04517	1115512.EH105704_01_01750	8e-44	183.3	Escherichia													Bacteria	1RHGV@1224,1S6CQ@1236,3XQZM@561,COG1045@1,COG1045@2	NA|NA|NA	E	Serine acetyltransferase
C1_04519	399742.Ent638_4314	9.1e-41	172.6	Gammaproteobacteria	relE			ko:K06218					ko00000,ko02048				Bacteria	1MZ76@1224,1S8RR@1236,COG2026@1,COG2026@2	NA|NA|NA	DJ	Cytotoxic translational repressor of toxin-antitoxin stability system
C1_04520	502347.ESCAB7627_0420	7.7e-36	156.0	Escherichia	stbD			ko:K18923					ko00000,ko02048				Bacteria	1N6YR@1224,1S8RK@1236,3XR3K@561,COG2161@1,COG2161@2	NA|NA|NA	D	Antitoxin Phd_YefM, type II toxin-antitoxin system
C1_04521	573.JG24_02480	3.2e-115	421.8	Gammaproteobacteria	repA												Bacteria	1RC4P@1224,1S2PD@1236,28P1U@1,2ZBY2@2	NA|NA|NA	S	IncFII RepA protein family
C1_04523	343509.SG1212	1.2e-06	60.1	Bacteria	nusG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141		ko:K02601,ko:K05785					ko00000,ko03000,ko03009,ko03021				Bacteria	COG0250@1,COG0250@2	NA|NA|NA	K	Participates in transcription elongation, termination and antitermination
C1_04530	568768.CM001975_gene824	8e-15	88.6	Dickeya	pilL			ko:K02487,ko:K18353	ko01502,ko02020,map01502,map02020	M00507,M00651			ko00000,ko00001,ko00002,ko01504,ko02022,ko02035				Bacteria	1MXMF@1224,1TA7J@1236,2JF6I@204037,COG3266@1,COG3266@2	NA|NA|NA	S	Integrating conjugative element protein PilL
C1_04531	243265.plu1050	2e-08	65.9	Gammaproteobacteria													Bacteria	1N3RY@1224,1SAHG@1236,2D4GY@1,32TH3@2	NA|NA|NA	S	PilM
C1_04532	1441930.Z042_07625	1.4e-98	367.1	Gammaproteobacteria	pilN												Bacteria	1NQ25@1224,1S00D@1236,COG1450@1,COG1450@2	NA|NA|NA	NU	Type II secretory pathway, component PulD
C1_04533	1005994.GTGU_04258	6.4e-25	122.1	Gammaproteobacteria	pilO												Bacteria	1R9AT@1224,1RX3K@1236,28JMG@1,2Z9DZ@2	NA|NA|NA	S	Pilin accessory protein (PilO)
C1_04534	1441930.Z042_07610	4.6e-07	61.2	Serratia													Bacteria	1QQT6@1224,1RTGV@1236,2BIB6@1,32CGY@2,405E1@613	NA|NA|NA		
C1_04535	1441930.Z042_07605	2.2e-93	349.7	Serratia	pilQ												Bacteria	1R9U0@1224,1RSBE@1236,404XN@613,COG2804@1,COG2804@2	NA|NA|NA	NU	Type II/IV secretion system protein
C1_04536	716541.ECL_00420	5.8e-48	198.4	Gammaproteobacteria	pilR	GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0016020,GO:0032940,GO:0033036,GO:0042886,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098776		ko:K02455,ko:K10934	ko03070,ko05110,ko05111,map03070,map05110,map05111	M00331			ko00000,ko00001,ko00002,ko02044	3.A.15			Bacteria	1RAQ3@1224,1RQQ4@1236,COG1459@1,COG1459@2	NA|NA|NA	NU	Type II secretion system (T2SS), protein F
C1_04537	1149133.ppKF707_2247	7.4e-08	64.3	Pseudomonas aeruginosa group													Bacteria	1PJBG@1224,1TCC0@1236,1YK5Y@136841,2A8ED@1,30XG6@2	NA|NA|NA	S	PilS N terminal
C1_04538	568768.CM001975_gene832	4.2e-41	174.5	Gammaproteobacteria	pilT												Bacteria	1MZU4@1224,1RXXU@1236,COG0741@1,COG0741@2	NA|NA|NA	M	Transglycosylase SLT domain
C1_04540	1166016.W5S_3530	1.5e-35	157.5	Pectobacterium													Bacteria	1MRSH@122277,1QXC0@1224,1T379@1236,2E2ZJ@1,32Y06@2	NA|NA|NA	S	Bacterial shufflon protein, N-terminal constant region
C1_04542	220341.16505330	1.7e-146	525.8	Gammaproteobacteria	rci												Bacteria	1NWGS@1224,1RPST@1236,COG0582@1,COG0582@2	NA|NA|NA	L	Belongs to the 'phage' integrase family
C1_04543	561231.Pecwa_0706	1.2e-24	120.6	Pectobacterium													Bacteria	1MT0B@122277,1N4GV@1224,1S8ZX@1236,2E288@1,32XEB@2	NA|NA|NA		
C1_04544	716541.ECL_00526	1.7e-141	509.2	Enterobacter													Bacteria	1N1QM@1224,1RR0J@1236,28IW1@1,2Z8UB@2,3X1WM@547	NA|NA|NA	S	F plasmid transfer operon, TraF, protein
C1_04546	573.JG24_01925	5.4e-32	144.1	Gammaproteobacteria				ko:K12205					ko00000,ko02044	3.A.7.10.1,3.A.7.9.1			Bacteria	1N1SV@1224,1SBBB@1236,2C84D@1,32RKD@2	NA|NA|NA	S	DotD protein
C1_04547	1332071.L581_1527	1e-76	293.5	Gammaproteobacteria	dotC			ko:K12204					ko00000,ko02044	3.A.7.10.1,3.A.7.9.1			Bacteria	1MYQ8@1224,1RZGD@1236,COG1388@1,COG1388@2	NA|NA|NA	M	Type IV secretory system, conjugal DNA-protein transfer
C1_04548	1332071.L581_1528	1.3e-114	419.9	Serratia	dotB			ko:K12203					ko00000,ko02044	3.A.7.10.1,3.A.7.9.1			Bacteria	1MU3J@1224,1RN8G@1236,4000U@613,COG2805@1,COG2805@2	NA|NA|NA	NU	Type II/IV secretion system protein
C1_04549	573.JG24_01940	4e-20	104.0	Gammaproteobacteria				ko:K12222					ko00000,ko02044	3.A.7.10.1,3.A.7.9.1			Bacteria	1NDJU@1224,1SDG6@1236,2E6TC@1,331DA@2	NA|NA|NA		
C1_04550	1332071.L581_1531	1.3e-102	381.7	Gammaproteobacteria			6.3.2.4	ko:K01921,ko:K06919,ko:K08086,ko:K08307	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502		R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011				Bacteria	1R7S0@1224,1RVCF@1236,COG3170@1,COG3170@2,COG4643@1,COG4643@2	NA|NA|NA	NU	Tfp pilus assembly protein FimV
C1_04552	1332071.L581_1533	3.2e-39	168.7	Gammaproteobacteria	icmL			ko:K12214					ko00000,ko02044	3.A.7.10.1,3.A.7.9.1			Bacteria	1RGI1@1224,1S56Y@1236,2BVH1@1,32QVP@2	NA|NA|NA	S	Type-IV b secretion system, inner-membrane complex component
C1_04553	1332071.L581_1534	9e-77	293.9	Gammaproteobacteria	icmK			ko:K12213					ko00000,ko02044	3.A.7.10.1,3.A.7.9.1			Bacteria	1N2P6@1224,1RRXA@1236,2CPXU@1,32SK2@2	NA|NA|NA	S	Putative outer membrane core complex of type IVb secretion
C1_04554	1229485.AMYV01000083_gene3483	1e-62	247.7	Gammaproteobacteria				ko:K12209					ko00000,ko02044	3.A.7.9.1			Bacteria	1R7K8@1224,1RRJ6@1236,28KP9@1,2ZA7E@2	NA|NA|NA	S	Bacterial conjugation TrbI-like protein
C1_04555	1229485.AMYV01000083_gene3482	2.7e-11	76.3	Gammaproteobacteria				ko:K12211					ko00000,ko02044	3.A.7.9.1			Bacteria	1NWB6@1224,1SNWM@1236,2F5BA@1,33XXE@2	NA|NA|NA		
C1_04556	1229485.AMYV01000083_gene3481	2.5e-23	115.5	Gammaproteobacteria													Bacteria	1RM2Z@1224,1S7DC@1236,2BF2T@1,328UU@2	NA|NA|NA		
C1_04558	36870.25166296	1.7e-40	172.6	Gammaproteobacteria	nuc			ko:K06131	ko00564,ko01100,map00564,map01100		R07390	RC00017	ko00000,ko00001,ko01000				Bacteria	1RK7U@1224,1T0HC@1236,COG1502@1,COG1502@2	NA|NA|NA	I	PLD-like domain
C1_04559	1332071.L581_1540	1.6e-09	70.1	Gammaproteobacteria													Bacteria	1NUVJ@1224,1SNHY@1236,2DV93@1,33USS@2	NA|NA|NA		
C1_04560	1229485.AMYV01000083_gene3478	2.7e-308	1064.7	Gammaproteobacteria	icmB			ko:K12206					ko00000,ko02044	3.A.7.9.1			Bacteria	1MWW7@1224,1RQMQ@1236,COG0433@1,COG0433@2,COG3451@1,COG3451@2	NA|NA|NA	U	type IV secretory pathway VirB4
C1_04561	573.JG24_02005	1e-61	243.8	Gammaproteobacteria													Bacteria	1R56Z@1224,1RZS4@1236,28I39@1,2Z874@2	NA|NA|NA		
C1_04562	223283.PSPTO_A0063	3.3e-10	72.0	Gammaproteobacteria													Bacteria	1NXR0@1224,1SPZ1@1236,2F7WH@1,340AG@2	NA|NA|NA		
C1_04564	1229485.AMYV01000119_gene3528	1.2e-172	613.6	Gammaproteobacteria													Bacteria	1QUD6@1224,1RP7Y@1236,28NBP@1,2ZBEY@2	NA|NA|NA		
C1_04567	637910.ROD_42472	2.7e-07	60.5	Gammaproteobacteria	hokA			ko:K18919,ko:K18920					ko00000,ko02048				Bacteria	1NF35@1224,1SFFW@1236,2EFY7@1,337V7@2	NA|NA|NA	S	PFAM Hok gef
C1_04568	637910.ROD_p2291	1.9e-162	579.7	Citrobacter	topB		5.99.1.2	ko:K03168,ko:K03169,ko:K07479					ko00000,ko01000,ko03032,ko03400				Bacteria	1MUFZ@1224,1RN4X@1236,3WVAG@544,COG0550@1,COG0550@2,COG0551@1,COG0551@2	NA|NA|NA	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C1_04569	1332071.L581_1546	7.9e-54	218.0	Gammaproteobacteria	icmP			ko:K12218					ko00000,ko02044	3.A.7.10.1,3.A.7.9.1			Bacteria	1RJER@1224,1S6F3@1236,2CA66@1,31YVT@2	NA|NA|NA		
C1_04570	1229485.AMYV01000119_gene3525	1.6e-41	177.2	Gammaproteobacteria				ko:K12228					ko00000,ko02044	3.A.7.10.1			Bacteria	1MYHA@1224,1S7JM@1236,COG1651@1,COG1651@2	NA|NA|NA	O	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C1_04571	500637.PROVRUST_08416	3.4e-50	204.9	Gammaproteobacteria													Bacteria	1NH5A@1224,1SGTR@1236,2EPIG@1,33H54@2	NA|NA|NA		
C1_04572	469008.B21_03473	1.5e-80	305.4	Escherichia	ssb	GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006298,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008047,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030234,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0042802,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:0098772,GO:1901360,GO:1901363,GO:1901576		ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440				ko00000,ko00001,ko03029,ko03032,ko03400				Bacteria	1RCWT@1224,1S3WP@1236,3XMYI@561,COG0629@1,COG0629@2	NA|NA|NA	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
C1_04573	469008.B21_03474	2.1e-196	692.6	Gammaproteobacteria	icmO			ko:K12217					ko00000,ko02044	3.A.7.10.1,3.A.7.9.1			Bacteria	1MV0M@1224,1RSC0@1236,COG3505@1,COG3505@2	NA|NA|NA	U	Type IV secretory pathway VirD4
C1_04574	155864.EDL933_p0088	7.8e-113	415.2	Gammaproteobacteria													Bacteria	1QUDG@1224,1RSQW@1236,COG3843@1,COG3843@2	NA|NA|NA	U	Relaxase/Mobilisation nuclease domain
C1_04575	573.JG24_01885	1.9e-15	88.6	Gammaproteobacteria													Bacteria	1NEFP@1224,1SQTB@1236,2E8NX@1,33304@2	NA|NA|NA		
C1_04576	1229485.AMYV01000119_gene3519	5.3e-11	73.9	Gammaproteobacteria													Bacteria	1P555@1224,1ST73@1236,28XYR@1,2ZJUN@2	NA|NA|NA		
C1_04578	1332071.L581_1507	2e-83	315.8	Serratia													Bacteria	1MUZW@1224,1RSAY@1236,401RF@613,COG0827@1,COG0827@2	NA|NA|NA	L	Domain of unknown function (DUF4942)
C1_04581	371042.NG99_16895	1.1e-89	336.7	Gammaproteobacteria													Bacteria	1MUSP@1224,1RNUW@1236,COG5464@1,COG5464@2	NA|NA|NA	S	Transposase
C1_04582	1114922.CIFAM_22_00120	1.7e-09	68.6	Citrobacter													Bacteria	1QNHA@1224,1TM2X@1236,2ESHU@1,31QYK@2,3WZPY@544	NA|NA|NA		
C1_04583	1141136.K4F707_9CAUD	3e-11	75.1	Myoviridae													Viruses	4QEJG@10239,4QI5Z@10662,4QU8Z@28883,4R02Y@35237	NA|NA|NA		
C1_04584	571.MC52_30280	8.7e-55	219.9	Gammaproteobacteria	ard												Bacteria	1RGJX@1224,1S45W@1236,COG4734@1,COG4734@2	NA|NA|NA	S	Antirestriction protein (ArdA)
C1_04585	1458706.A0A096XER3_9CAUD	1.2e-13	83.6	Podoviridae													Viruses	4QHQ1@10239,4QNPF@10744,4QUDS@28883,4QXZ1@35237	NA|NA|NA		
C1_04586	155864.EDL933_p0087	1.4e-77	296.2	Escherichia	psiA												Bacteria	1RFX4@1224,1S5K4@1236,29AWV@1,2ZXW0@2,3XQT2@561	NA|NA|NA	S	PsiA protein
C1_04587	754331.AEME01000001_gene3329	1.8e-64	251.9	Escherichia	psiB												Bacteria	1NBCK@1224,1SCFX@1236,2EAYP@1,334ZM@2,3XQ71@561	NA|NA|NA	S	Plasmid SOS inhibition protein (PsiB)
C1_04588	754331.AEME01000001_gene3328	0.0	1208.4	Escherichia	yubM			ko:K03497					ko00000,ko03000,ko03036,ko04812				Bacteria	1MVF9@1224,1RR8P@1236,3XQF9@561,COG1475@1,COG1475@2	NA|NA|NA	K	ParB-like nuclease domain
C1_04589	754331.AEME01000001_gene3327	1.5e-38	164.9	Escherichia													Bacteria	1QING@1224,1TGHS@1236,2A5HI@1,30U7R@2,3XR3F@561	NA|NA|NA	S	Bacterial protein of unknown function (DUF905)
C1_04590	754331.AEME01000001_gene3326	2.5e-60	238.4	Escherichia	ssb	GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006298,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008047,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030234,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0042802,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:0098772,GO:1901360,GO:1901363,GO:1901576		ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440				ko00000,ko00001,ko03029,ko03032,ko03400				Bacteria	1RCWT@1224,1S3WP@1236,3XQQG@561,COG0629@1,COG0629@2	NA|NA|NA	L	Single-strand binding protein family
C1_04591	155864.EDL933_p0077	1.9e-26	124.4	Escherichia													Bacteria	1NMP2@1224,1SGW6@1236,2ET5W@1,33KPY@2,3XR96@561	NA|NA|NA		
C1_04592	155864.EDL933_p0076	3.1e-69	267.7	Escherichia													Bacteria	1P4TQ@1224,1SU5S@1236,2DDV0@1,2ZJDM@2,3XR5V@561	NA|NA|NA		
C1_04593	155864.EDL933_p0075	3.1e-77	294.3	Gammaproteobacteria													Bacteria	1N1W2@1224,1SBCR@1236,2DNA7@1,32WE3@2	NA|NA|NA	S	Antirestriction protein
C1_04594	155864.EDL933_p0074	5e-134	483.8	Escherichia													Bacteria	1QGBT@1224,1TDR8@1236,2CCC6@1,31INX@2,3XQH7@561	NA|NA|NA		
C1_04595	754331.AEME01000001_gene2245	1.8e-69	268.5	Escherichia													Bacteria	1RIHW@1224,1S7FM@1236,2BKJJ@1,32F0T@2,3XQFK@561	NA|NA|NA	S	Protein of unknown function (DUF1380)
C1_04596	754331.AEME01000001_gene2244	1.8e-33	147.9	Gammaproteobacteria													Bacteria	1NHP1@1224,1SGVJ@1236,2ESQW@1,33K9C@2	NA|NA|NA		
C1_04597	198214.CP0198	6.6e-130	469.9	Gammaproteobacteria			2.1.1.72	ko:K00571,ko:K07319					ko00000,ko01000,ko02048				Bacteria	1R7KV@1224,1RZ25@1236,COG0863@1,COG0863@2	NA|NA|NA	L	Belongs to the N(4) N(6)-methyltransferase family
C1_04598	198214.CP0196	2e-185	654.8	Gammaproteobacteria													Bacteria	1NNXE@1224,1RQNW@1236,2DBDM@1,2Z8MT@2	NA|NA|NA	S	Protein of unknown function (DUF1281)
C1_04599	571.MC52_30245	4.6e-17	93.6	Bacteria				ko:K12149					ko00000,ko03400				Bacteria	2C6FZ@1,2ZKIJ@2	NA|NA|NA	S	DinI-like family
C1_04600	571.MC52_30240	9.6e-42	176.4	Gammaproteobacteria				ko:K03503					ko00000,ko01000,ko01002,ko03400				Bacteria	1MZFA@1224,1S5X5@1236,COG1974@1,COG1974@2	NA|NA|NA	KT	Belongs to the peptidase S24 family
C1_04601	571.MC52_30235	3.3e-175	621.3	Gammaproteobacteria	umuC		2.7.7.7	ko:K02346,ko:K03502					ko00000,ko01000,ko03400				Bacteria	1MUUH@1224,1RMT1@1236,COG0389@1,COG0389@2	NA|NA|NA	L	DNA polymerase
C1_04602	66269.NL54_21970	5.6e-07	60.8	Gammaproteobacteria													Bacteria	1NI2Q@1224,1SHW9@1236,2DSQV@1,33H3G@2	NA|NA|NA	S	Plasmid stability protein
C1_04603	573.JG24_01795	8e-113	413.7	Gammaproteobacteria	yegD			ko:K04046,ko:K18640					ko00000,ko03110,ko04812	1.A.33			Bacteria	1R4I4@1224,1RRY4@1236,COG0443@1,COG0443@2	NA|NA|NA	O	PFAM StbA family protein
C1_04604	1458706.A0A096XER3_9CAUD	6.7e-24	116.7	Podoviridae													Viruses	4QHQ1@10239,4QNPF@10744,4QUDS@28883,4QXZ1@35237	NA|NA|NA		
C1_04605	1224318.DT73_12550	1.9e-28	131.7	Gammaproteobacteria	ycfB												Bacteria	1RHVW@1224,1S6VG@1236,COG1598@1,COG1598@2	NA|NA|NA	K	HicB_like antitoxin of bacterial toxin-antitoxin system
C1_04607	637910.ROD_p2001	4.9e-57	226.9	Gammaproteobacteria	hicB												Bacteria	1PWGA@1224,1S6AD@1236,COG4226@1,COG4226@2	NA|NA|NA	S	protein encoded in hypervariable junctions of pilus gene clusters
C1_04608	637910.ROD_p2011	2.8e-38	164.1	Gammaproteobacteria													Bacteria	1NDYW@1224,1SG65@1236,2BIP3@1,32CWA@2	NA|NA|NA	S	HicA toxin of bacterial toxin-antitoxin,
C1_04610	1484157.PSNIH2_19995	4.2e-19	100.5	Pantoea													Bacteria	1QIMD@1224,1TGGG@1236,2AV1U@1,31KRP@2,3W2BC@53335	NA|NA|NA		
C1_04612	637910.ROD_p2051	6.5e-19	99.8	Gammaproteobacteria													Bacteria	1NHPU@1224,1SGI1@1236,2EQSY@1,33ICR@2	NA|NA|NA		
C1_04616	675812.VHA_000041	5.1e-16	90.5	Vibrionales													Bacteria	1QK4Z@1224,1TI83@1236,1XYM2@135623,28P3F@1,2ZBZ4@2	NA|NA|NA		
C1_04617	573.JG24_01835	9.8e-23	112.8	Gammaproteobacteria													Bacteria	1NKQA@1224,1SJBA@1236,2EK02@1,33DQM@2	NA|NA|NA		
C1_04618	573.JG24_00245	1.1e-89	336.3	Bacteria				ko:K03496					ko00000,ko03036,ko04812				Bacteria	COG1192@1,COG1192@2	NA|NA|NA	D	plasmid maintenance
C1_04619	573.JG24_00240	2.4e-17	94.7	Gammaproteobacteria													Bacteria	1NP2J@1224,1SJ2J@1236,2EPC8@1,33GYZ@2	NA|NA|NA		
C1_04620	243277.VC_1497	2e-07	62.8	Vibrionales	proQ	GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003727,GO:0003729,GO:0003730,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006970,GO:0006972,GO:0006974,GO:0007154,GO:0007165,GO:0007231,GO:0008150,GO:0009628,GO:0009651,GO:0009987,GO:0010468,GO:0010608,GO:0010958,GO:0019222,GO:0023052,GO:0032879,GO:0032890,GO:0032892,GO:0033554,GO:0033592,GO:0034057,GO:0034762,GO:0034764,GO:0034765,GO:0034767,GO:0042538,GO:0042710,GO:0043269,GO:0043270,GO:0044010,GO:0044070,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0048518,GO:0050789,GO:0050794,GO:0050896,GO:0051049,GO:0051050,GO:0051704,GO:0051716,GO:0051952,GO:0051954,GO:0051955,GO:0051957,GO:0060255,GO:0065007,GO:0070881,GO:0071214,GO:0071470,GO:0071472,GO:0071474,GO:0071475,GO:0097159,GO:0097617,GO:0104004,GO:1901363,GO:1902834,GO:1902836,GO:1903789,GO:1903793,GO:1903959,GO:1903961,GO:1904062,GO:1904064		ko:K03607					ko00000				Bacteria	1N68T@1224,1RP4S@1236,1XT78@135623,COG3109@1,COG3109@2	NA|NA|NA	J	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
C1_04622	481805.EcolC_0023	2.1e-205	721.5	Escherichia	Z012_11195			ko:K07496					ko00000				Bacteria	1MUU0@1224,1RS1J@1236,3XPN5@561,COG0675@1,COG0675@2	NA|NA|NA	L	Transposase
C1_04623	1120970.AUBZ01000066_gene3378	3.4e-13	80.1	Gammaproteobacteria													Bacteria	1NGXK@1224,1SHSZ@1236,2EG9H@1,33A1A@2	NA|NA|NA		
C1_04624	573.JG24_02480	5.6e-117	427.6	Gammaproteobacteria	repA												Bacteria	1RC4P@1224,1S2PD@1236,28P1U@1,2ZBY2@2	NA|NA|NA	S	IncFII RepA protein family
C1_04625	243265.plu0270	4.2e-08	64.7	Gammaproteobacteria													Bacteria	1NNF9@1224,1SHU2@1236,2C9U5@1,33N75@2	NA|NA|NA	S	CaiF/GrlA transcriptional regulator
C1_04627	637730.C8XUQ9_9CAUD	1.5e-09	68.2	Myoviridae													Viruses	4QF4W@10239,4QIMX@10662,4QTG4@28883,4QXFN@35237	NA|NA|NA		
C1_04628	1484158.PSNIH1_09835	1e-91	343.6	Pantoea	qmcA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Bacteria	1MUM8@1224,1RNW8@1236,3VZD7@53335,COG0330@1,COG0330@2	NA|NA|NA	O	Band 7 protein
C1_04630	1484157.PSNIH2_12470	1.3e-09	69.7	Pantoea	ybbJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K07340					ko00000				Bacteria	1N241@1224,1S5W4@1236,3W0M9@53335,COG1585@1,COG1585@2	NA|NA|NA	OU	membrane
C1_04635	1166016.W5S_2323	2.3e-54	219.5	Gammaproteobacteria				ko:K03201	ko03070,map03070	M00333			ko00000,ko00001,ko00002,ko02044	3.A.7			Bacteria	1RGQN@1224,1T0W7@1236,COG3704@1,COG3704@2	NA|NA|NA	U	TrbL/VirB6 plasmid conjugal transfer protein
C1_04636	1028806.GGE_1604	2.9e-10	72.4	Gammaproteobacteria				ko:K03200	ko03070,map03070	M00333			ko00000,ko00001,ko00002,ko02044	3.A.7			Bacteria	1NJCA@1224,1SGUE@1236,2EGTW@1,33AK2@2	NA|NA|NA	S	Type IV secretion system proteins
C1_04638	325777.GW15_0210300	1.6e-29	136.7	Proteobacteria	xseA		3.1.11.6	ko:K03601	ko03430,map03430				ko00000,ko00001,ko01000,ko03400				Bacteria	1QZ1C@1224,COG1570@1,COG1570@2	NA|NA|NA	L	exodeoxyribonuclease VII activity
C1_04639	637910.ROD_p2371	1.9e-33	148.3	Gammaproteobacteria	kikA												Bacteria	1N527@1224,1S8VP@1236,2E2MR@1,32XQV@2	NA|NA|NA	S	TrbM
C1_04640	1224136.AMFN01000014_gene2616	3.8e-27	129.4	unclassified Enterobacteriaceae				ko:K11894					ko00000,ko02044	3.A.23.1			Bacteria	1QQT4@1224,1RTGT@1236,283IX@191675,COG3266@1,COG3266@2	NA|NA|NA	S	Toxin co-regulated pilus biosynthesis protein Q
C1_04641	572265.HDEF_1346	6.1e-20	104.0	unclassified Enterobacteriaceae													Bacteria	1QQTE@1224,1RTH0@1236,283NR@191675,29GRJ@1,303PE@2	NA|NA|NA	S	PilM
C1_04643	465817.ETA_pET350040	6.8e-27	127.5	Erwinia	virB1			ko:K03194	ko03070,map03070	M00333			ko00000,ko00001,ko00002,ko02044				Bacteria	1N00I@1224,1TF0C@1236,3X7WN@551,COG0741@1,COG0741@2	NA|NA|NA	M	Transglycosylase SLT domain
C1_04644	1028805.GGC_1121	2.5e-14	84.7	Proteobacteria													Bacteria	1P4CC@1224,2CJTC@1,2ZVIU@2	NA|NA|NA		
C1_04646	1028805.GGC_1123	6.9e-195	687.6	Gammaproteobacteria	lvhB4			ko:K03199,ko:K20530	ko02024,ko03070,map02024,map03070	M00333			ko00000,ko00001,ko00002,ko02044	3.A.7,3.A.7.4			Bacteria	1MXH0@1224,1RQW2@1236,COG3451@1,COG3451@2	NA|NA|NA	U	type IV secretory pathway, VirB4 components
C1_04648	1028805.GGC_1126	6.8e-40	171.0	Gammaproteobacteria				ko:K03203	ko03070,map03070	M00333			ko00000,ko00001,ko00002,ko02044	3.A.7			Bacteria	1MYE6@1224,1T0B6@1236,COG3736@1,COG3736@2	NA|NA|NA	U	VirB8 protein
C1_04649	465817.ETA_pET350110	5.1e-46	191.4	Erwinia	virB9			ko:K03204	ko03070,map03070	M00333			ko00000,ko00001,ko00002,ko02044	3.A.7			Bacteria	1QJQM@1224,1TEIF@1236,3X7XP@551,COG3504@1,COG3504@2	NA|NA|NA	U	Conjugal transfer protein
C1_04650	465817.ETA_pET350120	2.8e-56	226.1	Erwinia	virB10			ko:K03195,ko:K12082	ko03070,map03070	M00333			ko00000,ko00001,ko00002,ko02044	3.A.7,3.A.7.3.1			Bacteria	1MXVX@1224,1RSE1@1236,3X7UP@551,COG2948@1,COG2948@2	NA|NA|NA	U	Bacterial conjugation TrbI-like protein
C1_04651	870967.VIS19158_11783	2.5e-96	359.0	Vibrionales	virB11			ko:K02283,ko:K03196	ko03070,ko05120,map03070,map05120	M00333,M00564			ko00000,ko00001,ko00002,ko02035,ko02044	3.A.7			Bacteria	1R82Y@1224,1T07N@1236,1Y052@135623,COG0630@1,COG0630@2	NA|NA|NA	NU	COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis
C1_04652	465817.ETA_pET350140	5.5e-113	415.2	Gammaproteobacteria	virD4			ko:K03205	ko03070,map03070	M00333			ko00000,ko00001,ko00002,ko02044	3.A.7			Bacteria	1MV1G@1224,1RNF5@1236,COG3505@1,COG3505@2	NA|NA|NA	U	Type IV secretory pathway, VirD4 components
C1_04654	572265.HDEF_1347	9.3e-138	497.3	unclassified Enterobacteriaceae	mshL			ko:K02453,ko:K02666,ko:K12282	ko03070,ko05111,map03070,map05111	M00331			ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2			Bacteria	1QVDE@1224,1T2C9@1236,283BF@191675,COG4796@1,COG4796@2	NA|NA|NA	U	Secretin N-terminal domain
C1_04655	572265.HDEF_1348	6.8e-67	261.5	unclassified Enterobacteriaceae													Bacteria	1PVIS@1224,1TBST@1236,283FW@191675,2AFFN@1,315FS@2	NA|NA|NA	S	Pilin accessory protein (PilO)
C1_04656	1224136.AMFN01000014_gene2612	3e-10	72.0	unclassified Enterobacteriaceae													Bacteria	1QQT7@1224,1RTGW@1236,283KW@191675,2BI8H@1,32CDX@2	NA|NA|NA		
C1_04657	572265.HDEF_1350	5.4e-140	504.6	unclassified Enterobacteriaceae	pilQ												Bacteria	1R9U0@1224,1RSBE@1236,282XD@191675,COG2804@1,COG2804@2	NA|NA|NA	NU	Type II/IV secretion system protein
C1_04658	572265.HDEF_1227	9.3e-41	174.5	Bacteria	pilR	GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0016020,GO:0032940,GO:0033036,GO:0042886,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098776		ko:K02455,ko:K02505,ko:K10934	ko03070,ko05110,ko05111,map03070,map05110,map05111	M00331			ko00000,ko00001,ko00002,ko02044	3.A.15			Bacteria	COG1459@1,COG1459@2	NA|NA|NA	U	protein transport across the cell outer membrane
C1_04660	572265.HDEF_0956	1.5e-40	172.6	unclassified Enterobacteriaceae	pilT												Bacteria	1MZU4@1224,1S4BQ@1236,283FS@191675,COG0741@1,COG0741@2	NA|NA|NA	M	Transglycosylase SLT domain
C1_04662	1005994.GTGU_04265	2.7e-68	266.2	Gammaproteobacteria	pilV	GO:0003674,GO:0005198,GO:0005575,GO:0005623,GO:0008150,GO:0009289,GO:0009405,GO:0009987,GO:0016043,GO:0030030,GO:0042995,GO:0044419,GO:0044464,GO:0051704,GO:0071840		ko:K02457,ko:K02458,ko:K10926,ko:K10930,ko:K10931	ko03070,ko05110,ko05111,map03070,map05110,map05111	M00331			ko00000,ko00001,ko00002,ko02044	3.A.15			Bacteria	1P5SN@1224,1RSQK@1236,COG2165@1,COG2165@2	NA|NA|NA	NU	Bacterial shufflon protein, N-terminal constant region
C1_04663	568768.CM001975_gene834	3.8e-12	77.4	Gammaproteobacteria	pilV	GO:0003674,GO:0005198,GO:0005575,GO:0005623,GO:0008150,GO:0009289,GO:0009405,GO:0009987,GO:0016043,GO:0030030,GO:0042995,GO:0044419,GO:0044464,GO:0051704,GO:0071840		ko:K02457,ko:K02458,ko:K10926,ko:K10930,ko:K10931	ko03070,ko05110,ko05111,map03070,map05110,map05111	M00331			ko00000,ko00001,ko00002,ko02044	3.A.15			Bacteria	1P5SN@1224,1RSQK@1236,COG2165@1,COG2165@2	NA|NA|NA	NU	Bacterial shufflon protein, N-terminal constant region
C1_04664	220341.16505330	2.7e-152	545.0	Gammaproteobacteria	rci												Bacteria	1NWGS@1224,1RPST@1236,COG0582@1,COG0582@2	NA|NA|NA	L	Belongs to the 'phage' integrase family
C1_04666	637910.ROD_p2331	1.3e-66	259.2	Gammaproteobacteria			3.1.31.1	ko:K01174					ko00000,ko01000				Bacteria	1N145@1224,1S9I3@1236,COG1525@1,COG1525@2	NA|NA|NA	L	nuclease
C1_04667	457398.HMPREF0326_02655	1.2e-07	65.1	Bacteria													Bacteria	2ETGX@1,33M0T@2	NA|NA|NA	S	PcfJ-like protein
C1_04668	637910.ROD_p2301	7e-109	399.8	Gammaproteobacteria													Bacteria	1P19W@1224,1SV6H@1236,2FBZS@1,34440@2	NA|NA|NA		
C1_04669	637910.ROD_p2291	0.0	1275.4	Citrobacter	topB		5.99.1.2	ko:K03168,ko:K03169,ko:K07479					ko00000,ko01000,ko03032,ko03400				Bacteria	1MUFZ@1224,1RN4X@1236,3WVAG@544,COG0550@1,COG0550@2,COG0551@1,COG0551@2	NA|NA|NA	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C1_04672	362663.ECP_2998	6.3e-20	102.8	Gammaproteobacteria													Bacteria	1P216@1224,1SSWR@1236,2CN5N@1,349RM@2	NA|NA|NA	S	Haemolysin expression modulating protein
C1_04677	465817.ETA_pET350280	1.2e-103	385.2	Gammaproteobacteria				ko:K03203	ko03070,map03070	M00333			ko00000,ko00001,ko00002,ko02044	3.A.7			Bacteria	1R0FX@1224,1T4GP@1236,COG3736@1,COG3736@2	NA|NA|NA	U	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C1_04678	870967.VIS19158_11533	4.1e-16	90.9	Vibrionales													Bacteria	1QMS0@1224,1TK1S@1236,1Y1YQ@135623,2AY1H@1,31Q38@2	NA|NA|NA	S	Bacterial mobilisation protein (MobC)
C1_04680	1028805.GGC_1138	1.8e-64	252.7	Gammaproteobacteria	traL			ko:K03496					ko00000,ko03036,ko04812				Bacteria	1R4EP@1224,1S10G@1236,COG1192@1,COG1192@2	NA|NA|NA	D	conjugal transfer protein TraL
# 4427 queries scanned
# Total time (seconds): 1450.43704915
# Rate: 3.05 q/s