MAG.C2.12	MAG.T11.11	MAG.T11.14	MAG.T11.1	MAG.T11.25	MAG.T11.24	MAG.T11.56	MAG.T11.57	MAG.T11.72	MAG.T11.77	MAG.T13.29	MAG.T11.59	MAG.T12.26	MAG.T13.20	MAG.T12.46	MAG.T12.69	MAG.T13.57	MAG.T13.59	MAG.T22.36	MAG.T23.20	MAG.T23.60	MAG.T13.71	MAG.T13.60	MAG.T13.83	MAG.T13.85	MAG.T23.24	MAG.T21.30	MAG.T13.90	MAG.T21.70	MAG.T21.39	MAG.T22.48	MAG.T22.49	MAG.T23.71	Pathogen	ARO Name	AMR Gene Family	Drug Class	Resistance Mechanism	Short Name	Description
ARO:3000165	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Shigella sonnei	tet(A)	major facilitator superfamily (MFS) antibiotic efflux pump	tetracycline antibiotic	antibiotic efflux	tet(A)	TetA is a tetracycline efflux pump found in many species of Gram-negative bacteria.
ARO:3000167	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Aeromonas salmonicida	tet(C)	major facilitator superfamily (MFS) antibiotic efflux pump	tetracycline antibiotic	antibiotic efflux	tet(C)	Tet(C) is a tetracycline efflux pump found in many species of Gram-negative bacteria. It is typically found in plasmid DNA.
ARO:3000173	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Escherichia coli	tet(E)	major facilitator superfamily (MFS) antibiotic efflux pump	tetracycline antibiotic	antibiotic efflux	tet(E)	TetE is a tetracycline efflux pump found in many Gram-negative bacteria, especially those in water environments. The gene is found on large plasmids.
ARO:3000174	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Pseudomonas sp.	tet(G)	major facilitator superfamily (MFS) antibiotic efflux pump	tetracycline antibiotic	antibiotic efflux	tet(G)	TetG is a tetracycline efflux protein found in Gram-negative bacteria. The encoding gene is found in both chromosomal and plasmid DNA where it is frequently linked to the floR, sul1, and cmlA9 genes which encode proteins that can confer florfenicol/chloramphenicol, sulfamethoxazole, and chloramphenicol resistance, respectively.
ARO:3000182	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	IncQ plasmid pIE1120	tet(Y)	major facilitator superfamily (MFS) antibiotic efflux pump	tetracycline antibiotic	antibiotic efflux	tet(Y)	TetY is a tetracycline efflux pump found in Gram-negative bacteria (Aeromonas and Escherichia). It is associated with plasmid DNA.
ARO:3000205	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Bacteroides fragilis	tet(X)	tetracycline inactivation enzyme	glycylcycline | tetracycline antibiotic	antibiotic inactivation	tet(X)	Tet(X) is a flavin-dependent monooxygenase conferring resistance to tetracycline antibiotics. Tet(X) hydroxylates position 11a of the tetraketide group thus inactivating the antibiotic.
ARO:3000216	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Escherichia coli str. K-12 substr. MG1655	acrB	resistance-nodulation-cell division (RND) antibiotic efflux pump	cephalosporin | disinfecting agents and antiseptics | fluoroquinolone antibiotic | glycylcycline | penicillin beta-lactam | phenicol antibiotic | rifamycin antibiotic | tetracycline antibiotic	antibiotic efflux	acrB	Protein subunit of AcrA-AcrB-TolC multidrug efflux complex. AcrB functions as a herterotrimer which forms the inner membrane component and is primarily responsible for substrate recognition and energy transduction by acting as a drug/proton antiporter.
ARO:3000245	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Mycolicibacterium smegmatis MC2 155	RbpA	RbpA bacterial RNA polymerase-binding protein	rifamycin antibiotic	antibiotic target protection	RbpA	RNA-polymerase binding protein which confers resistance to rifampin.
ARO:3000343	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Mycolicibacterium fortuitum	tap	major facilitator superfamily (MFS) antibiotic efflux pump	tetracycline antibiotic	antibiotic efflux	tap	Efflux pump proteins contained within Mycobacterial genomes which confer resistance to a number of different antibiotics including aminoglycosides, and tetracyclines.
ARO:3000378	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Pseudomonas aeruginosa	MexB	resistance-nodulation-cell division (RND) antibiotic efflux pump	aminocoumarin antibiotic | carbapenem | cephalosporin | diaminopyrimidine antibiotic | fluoroquinolone antibiotic | macrolide antibiotic | monobactam | penicillin beta-lactam | peptide antibiotic | phenicol antibiotic | sulfonamide antibiotic | tetracycline antibiotic	antibiotic efflux	MexB	MexB is the inner membrane multidrug exporter of the efflux complex MexAB-OprM.
ARO:3000498	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Bacteroides fragilis	ErmF	Erm 23S ribosomal RNA methyltransferase	lincosamide antibiotic | macrolide antibiotic | streptogramin A antibiotic | streptogramin B antibiotic | streptogramin antibiotic	antibiotic target alteration	ErmF	ErmF confers the MLSb phenotype.
ARO:3000501	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	1.0	0.0	0.0	0.0	0.0	Nocardia farcinica IFM 10152	rpoB2	rifamycin-resistant beta-subunit of RNA polymerase (rpoB)	peptide antibiotic | rifamycin antibiotic	antibiotic target alteration | antibiotic target replacement	rpoB2	Due to gene duplication, the genomes of Nocardia species include both rifampin-sensitive beta-subunit of RNA polymerase (rpoB) and rifampin-resistant beta-subunit of RNA polymerase (rpoB2) genes, with ~88% similarity between the two gene products. Expression of the rpoB2 variant results in replacement of rifampin sensitivity with rifampin resistance.
ARO:3000604	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Bacteroides coprosuis DSM 18011	Erm(35)	Erm 23S ribosomal RNA methyltransferase	lincosamide antibiotic | macrolide antibiotic | streptogramin A antibiotic | streptogramin B antibiotic | streptogramin antibiotic	antibiotic target alteration	Erm(35)	ErmD confers MLSb phenotype.
ARO:3000616	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Streptococcus pyogenes	mel	msr-type ABC-F protein	macrolide antibiotic | streptogramin antibiotic	antibiotic target protection	mel	Mel, a homolog of MsrA, is an ABC-F subfamily protein associated with macrolide resistance. It is expressed on the same operon as mefA and mefE, both MFS-type efflux proteins that confer macrolide resistance.
ARO:3000775	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Acinetobacter baumannii	adeB	resistance-nodulation-cell division (RND) antibiotic efflux pump	glycylcycline | tetracycline antibiotic	antibiotic efflux	adeB	AdeB is the multidrug transporter of the adeABC efflux system.
ARO:3000777	0.0	0.0	0.0	0.0	0.0	2.0	0.0	0.0	2.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	Acinetobacter baumannii AYE	adeF	resistance-nodulation-cell division (RND) antibiotic efflux pump	fluoroquinolone antibiotic | tetracycline antibiotic	antibiotic efflux	adeF	AdeF is the membrane fusion protein of the multidrug efflux complex AdeFGH.
ARO:3000790	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	2.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	mdsB	resistance-nodulation-cell division (RND) antibiotic efflux pump	carbapenem | cephalosporin | monobactam | penicillin beta-lactam | phenicol antibiotic	antibiotic efflux	mdsB	MdsB is the inner membrane transporter of the multidrug and metal efflux complex MdsABC. mdsB corresponds to 1 locus in Pseudomonas aeruginosa PAO1 (gene name: mexQ) and 2 loci in Pseudomonas aeruginosa LESB58.
ARO:3000793	0.0	0.0	2.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	1.0	0.0	0.0	Escherichia coli str. K-12 substr. MG1655	mdtB	resistance-nodulation-cell division (RND) antibiotic efflux pump	aminocoumarin antibiotic	antibiotic efflux	mdtB	MdtB is a transporter that forms a heteromultimer complex with MdtC to form a multidrug transporter. MdtBC is part of the MdtABC-TolC efflux complex.
ARO:3000794	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	2.0	0.0	0.0	0.0	0.0	Escherichia coli str. K-12 substr. MG1655	mdtC	resistance-nodulation-cell division (RND) antibiotic efflux pump	aminocoumarin antibiotic	antibiotic efflux	mdtC	MdtC is a transporter that forms a heteromultimer complex with MdtB to form a multidrug transporter. MdtBC is part of the MdtABC-TolC efflux complex. In the absence of MdtB, MdtC can form a homomultimer complex that results in a functioning efflux complex with a narrower drug specificity. mdtC corresponds to 3 loci in Pseudomonas aeruginosa PAO1 (gene name: muxC/muxB) and 3 loci in Pseudomonas aeruginosa LESB58.
ARO:3000804	0.0	0.0	0.0	0.0	0.0	2.0	0.0	0.0	2.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Pseudomonas aeruginosa PAO1	MexF	resistance-nodulation-cell division (RND) antibiotic efflux pump	diaminopyrimidine antibiotic | fluoroquinolone antibiotic | phenicol antibiotic	antibiotic efflux	MexF	MexF is the multidrug inner membrane transporter of the MexEF-OprN complex. mexF corresponds to 2 loci in Pseudomonas aeruginosa PAO1 (gene name: mexF/mexB) and 4 loci in Pseudomonas aeruginosa LESB58 (gene name: mexD/mexB).
ARO:3000850	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Elizabethkingia meningoseptica	GOB-1	GOB beta-lactamase	carbapenem | cephalosporin | penicillin beta-lactam	antibiotic inactivation	GOB-1	GOB-1 confers resistance to cephalosporins in Elizabethkingia (Chryseobacterium) meningoseptica.
ARO:3001805	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Pseudomonas aeruginosa	OXA-198	OXA beta-lactamase | OXA-198-like beta-lactamase	carbapenem | penicillin beta-lactam	antibiotic inactivation	OXA-198	OXA-198 is a beta-lactamase found in Pseudomonas aeruginosa.
ARO:3002522	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	1.0	0.0	0.0	Streptomyces niveus	novA	ATP-binding cassette (ABC) antibiotic efflux pump	aminocoumarin antibiotic	antibiotic efflux	novA	A type III ABC transporter, identified on the novobiocin biosynthetic gene cluster, involved in the transport and resistance of novobiocin.
ARO:3002524	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Mycolicibacterium fortuitum	AAC(2')-Ib	AAC(2')	aminoglycoside antibiotic	antibiotic inactivation	AAC(2')-Ib	AAC(2')-Ib is a chromosomal-encoded aminoglycoside acetyltransferase in Mycolicibacterium fortuitum and A. baumannii.
ARO:3002525	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Mycobacterium tuberculosis H37Rv	AAC(2')-Ic	AAC(2')	aminoglycoside antibiotic	antibiotic inactivation	AAC(2')-Ic	AAC(2')-Ic is a chromosomal-encoded aminoglycoside acetyltransferase in M. tuberculosis and Mycobacterium tuberculosis variant bovis.
ARO:3002527	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Mycobacterium leprae	AAC(2')-Ie	AAC(2')	aminoglycoside antibiotic	antibiotic inactivation	AAC(2')-Ie	AAC(2')-Ie is a chromosomal-encoded aminoglycoside acetyltransferase in M. leprae.
ARO:3002539	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Escherichia coli	AAC(3)-IVa	AAC(3)	aminoglycoside antibiotic	antibiotic inactivation	AAC(3)-IVa	AAC(3)-IV is a plasmid-encoded aminoglycoside acetyltransferase in E. coli, C. jejuni and P. stutzeri.
ARO:3002598	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Serratia marcescens	ANT(3'')-II-AAC(6')-IId bifunctional protein	aminoglycoside bifunctional resistance protein	aminoglycoside antibiotic	antibiotic inactivation	ANT3II_ANT6II	ANT(3'')-II-AAC(6')-IId is an integron-encoded aminoglycoside acetyltransferase in S. marcescens.
ARO:3002601	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Escherichia coli	aadA	ANT(3'')	aminoglycoside antibiotic	antibiotic inactivation	aadA	ANT(3'')-Ia is an aminoglycoside nucleotidyltransferase gene encoded by plasmids, transposons, integrons in Enterobacteriaceae, A. baumannii, P. aeruginosa and Vibrio cholerae.
ARO:3002602	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Klebsiella pneumoniae	aadA2	ANT(3'')	aminoglycoside antibiotic	antibiotic inactivation	aadA2	aadA2 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and integrons in K. pneumoniae, Salmonella spp., Corynebacterium glutamicum, C. freundii and Aeromonas spp.
ARO:3002603	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Plasmid NR79	aadA3	ANT(3'')	aminoglycoside antibiotic	antibiotic inactivation	aadA3	aadA3 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids, transposons and integrons in E. coli.
ARO:3002604	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Acinetobacter baumannii	aadA4	ANT(3'')	aminoglycoside antibiotic	antibiotic inactivation	aadA4	aadA4 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and chromosomes in Bordetella parapertussis and E. coli.
ARO:3002605	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Escherichia coli	aadA5	ANT(3'')	aminoglycoside antibiotic	antibiotic inactivation	aadA5	aadA5 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids, transposons and integrons in E. coli, K. pneumoniae, Kluyvera georgiana, P. aeruginosa and E. cloacae.
ARO:3002606	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Pseudomonas aeruginosa	aadA6	ANT(3'')	aminoglycoside antibiotic	antibiotic inactivation	aadA6	aadA6 is an integron-encoded aminoglycoside nucleotidyltransferase gene in P. aeruginosa.
ARO:3002607	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Vibrio fluvialis	aadA7	ANT(3'')	aminoglycoside antibiotic	antibiotic inactivation	aadA7	aadA7 is an integron-encoded aminoglycoside nucleotidyltransferase gene in V. fluvialis, P. aeruginosa, E. coli, V. cholerae and S. enterica.
ARO:3002608	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	uncultured bacterium	aadA8	ANT(3'')	aminoglycoside antibiotic	antibiotic inactivation	aadA8	aadA8 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and integrons in V. cholerae, K. pneumoniae and Bacillus endophyticus.
ARO:3002609	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Corynebacterium sp. L2-79-05	aadA9	ANT(3'')	aminoglycoside antibiotic	antibiotic inactivation	aadA9	aadA9 is a plasmid-encoded aminoglycoside nucleotidyltransferase gene in C. glutamicum.
ARO:3002611	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Pseudomonas aeruginosa	aadA11	ANT(3'')	aminoglycoside antibiotic	antibiotic inactivation	aadA11	aadA11 is an integron-encoded aminoglycoside nucleotidyltransferase gene in E. coli and P. aeruginosa.
ARO:3002612	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Escherichia coli	aadA12	ANT(3'')	aminoglycoside antibiotic	antibiotic inactivation	aadA12	aadA12 is an integron-encoded aminoglycoside nucleotidyltransferase gene in E. coli, Yersinia enterocolitica and S. enterica.
ARO:3002613	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Pseudomonas aeruginosa	aadA13	ANT(3'')	aminoglycoside antibiotic	antibiotic inactivation	aadA13	aadA13 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and integrons in Pseudomonas rettgeri, P. aeruginosa, Y. enterocolitica and E. coli.
ARO:3002615	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Pseudomonas aeruginosa	aadA15	ANT(3'')	aminoglycoside antibiotic	antibiotic inactivation	aadA15	aadA15 is an integron-encoded aminoglycoside nucleotidyltransferase gene in P. aeruginosa.
ARO:3002616	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Escherichia coli	aadA16	ANT(3'')	aminoglycoside antibiotic	antibiotic inactivation	aadA16	aadA16 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and integrons in E. coli, V. cholerae and K. pneumoniae.
ARO:3002617	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Aeromonas media	aadA17	ANT(3'')	aminoglycoside antibiotic	antibiotic inactivation	aadA17	aadA17 is an integron-encoded aminoglycoside nucleotidyltransferase gene in Aeromonas media.
ARO:3002618	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Salmonella enterica subsp. enterica serovar Typhimurium	aadA21	ANT(3'')	aminoglycoside antibiotic	antibiotic inactivation	aadA21	aadA21 is an integron-encoded aminoglycoside nucleotidyltransferase gene in Salmonella spp.
ARO:3002619	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Salmonella enterica subsp. enterica serovar Typhimurium	aadA22	ANT(3'')	aminoglycoside antibiotic	antibiotic inactivation	aadA22	aadA22 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and integrons in S. enterica and E. coli.
ARO:3002620	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Salmonella enterica subsp. enterica serovar Agona	aadA23	ANT(3'')	aminoglycoside antibiotic	antibiotic inactivation	aadA23	aadA23 is an integron-encoded aminoglycoside nucleotidyltransferase gene in S. enterica.
ARO:3002621	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Salmonella enterica subsp. enterica serovar Newport	aadA24	ANT(3'')	aminoglycoside antibiotic	antibiotic inactivation	aadA24	aadA24 is an integron-encoded aminoglycoside nucleotidyltransferase gene in Salmonella spp.
ARO:3002622	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Pseudomonas aeruginosa	aadA6/aadA10	ANT(3'')	aminoglycoside antibiotic	antibiotic inactivation	aadA6/aadA10	aadA6/aadA10 is an integron-encoded aminoglycoside nucleotidyltransferase gene cassette in P. aeruginosa.
ARO:3002827	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Streptomyces fradiae	tlrC	Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins	lincosamide antibiotic | macrolide antibiotic	antibiotic target protection	tlrC	tlrC is an ABC-F subfamily protein found in Streptomyces fradiae and confers resistance to mycinamicin, tylosin and lincosamides. tlrC is found in the tylosin biosynthetic cluster and is one mechanism by which S. fradiae protects itself from self-destruction when producing this macrolide.
ARO:3002831	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	Staphylococcus aureus	vgaC	vga-type ABC-F protein	lincosamide antibiotic | pleuromutilin antibiotic | streptogramin A antibiotic | streptogramin antibiotic	antibiotic target protection	vgaC	vgaC is an ABC-F subfamily protein expressed in staphylococci that confers resistance to streptogramin A antibiotics and related compounds. It is associated with plasmid DNA.
ARO:3003010	0.0	0.0	0.0	0.0	0.0	2.0	0.0	0.0	2.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Burkholderia cepacia	ceoB	resistance-nodulation-cell division (RND) antibiotic efflux pump	aminoglycoside antibiotic | fluoroquinolone antibiotic	antibiotic efflux	ceoB	ceoB is a cytoplasmic membrane component of the CeoAB-OpcM efflux pump.
ARO:3003031	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Pseudomonas aeruginosa PAO1	MexW	resistance-nodulation-cell division (RND) antibiotic efflux pump	disinfecting agents and antiseptics | fluoroquinolone antibiotic | macrolide antibiotic | phenicol antibiotic | tetracycline antibiotic	antibiotic efflux	MexW	MexW is the RND-type membrane protein of the efflux complex MexVW-OprM.
ARO:3003035	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Mycobacterium tuberculosis H37Rv	mfpA	quinolone resistance protein (qnr)	fluoroquinolone antibiotic	antibiotic target protection	mfpA	mfpA is a qnr homolog and a pentapeptide repeat protein that confers resistance to fluoroquinolones in Mycolicibacterium smegmatis.
ARO:3003036	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Streptomyces antibioticus	oleB	Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins	macrolide antibiotic	antibiotic target protection	oleB	oleB is an ABC-F subfamily protein in Streptomyces antibioticus and is involved in oleandomycin secretion.
ARO:3003049	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Yersinia enterocolitica (type O:8)	rosB	major facilitator superfamily (MFS) antibiotic efflux pump	peptide antibiotic	antibiotic efflux	rosB	rosB is part of an efflux pump/potassium antiporter system (RosAB) in Yersinia that confers resistance to cationic antimicrobial peptides such as polymyxin B.
ARO:3003055	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	Stenotrophomonas maltophilia	smeD	resistance-nodulation-cell division (RND) antibiotic efflux pump	fluoroquinolone antibiotic | macrolide antibiotic | phenicol antibiotic | tetracycline antibiotic	antibiotic efflux	smeD	smeD is the membrane fusion protein of the smeDEF multidrug efflux complex in Stenotrophomonas maltophilia.
ARO:3003109	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Acinetobacter baumannii	msrE	msr-type ABC-F protein	macrolide antibiotic | streptogramin antibiotic	antibiotic target protection	msrE	MsrE is an ABC-F subfamily protein expressed to Klebsiella pneumoniae that confers resistance to erythromycin and streptogramin B antibiotics. It is associated with plasmid DNA. It is also 100% identical to ABC-F type ribosomal protection protein Msr(E) which is in multiple species.
ARO:3003197	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Pasteurella multocida 36950	aadA25	ANT(3'')	aminoglycoside antibiotic	antibiotic inactivation	aadA25	Streptomycin/spectinomycin resistance gene found in Pasteurella multocida isolated from bovine respiratory tract.
ARO:3003563	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Rhodobacter capsulatus	RCP-1	RCP beta-lactamase	penicillin beta-lactam	antibiotic inactivation	RCP-1	RCP is a class A beta-lactamase found in Rhodopseudomonas capsulata.
ARO:3003693	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Pseudomonas aeruginosa PAO1	MexK	resistance-nodulation-cell division (RND) antibiotic efflux pump	disinfecting agents and antiseptics | macrolide antibiotic | tetracycline antibiotic	antibiotic efflux	MexK	MexK is the inner membrane resistance-nodulation-cell division (RND) transporter in the MexJK multidrug efflux protein.
ARO:3003699	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Pseudomonas aeruginosa	mexQ	resistance-nodulation-cell division (RND) antibiotic efflux pump	carbapenem | diaminopyrimidine antibiotic | disinfecting agents and antiseptics | macrolide antibiotic | phenicol antibiotic | tetracycline antibiotic	antibiotic efflux	mexQ	MexQ is the inner membrane transporter of the multidrug efflux pump MexPQ-OpmE.
ARO:3003705	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	Pseudomonas aeruginosa	mexN	resistance-nodulation-cell division (RND) antibiotic efflux pump	phenicol antibiotic	antibiotic efflux	mexN	MexN is the inner membrane transporter of the MexMN-OprM multidrug efflux complex.
ARO:3003741	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	uncultured bacterium	mphE	macrolide phosphotransferase (MPH)	macrolide antibiotic	antibiotic inactivation	mphE	mphE is a macrolide phosphotransferase and resistance gene identified on a plasmid, pRSB105.
ARO:3003742	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Photobacterium damselae subsp. damselae	mphG	macrolide phosphotransferase (MPH)	macrolide antibiotic	antibiotic inactivation	mphG	The mphG gene encodes a macrolide 2'-phosphotransferase found in Photobacterium damselae sharing sequence similarity to mphA in E. coli.
ARO:3003745	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Photobacterium damselae subsp. damselae	mef(C)	major facilitator superfamily (MFS) antibiotic efflux pump	macrolide antibiotic | tetracycline antibiotic	antibiotic efflux	mef(C)	mef(C) is a macrolide efflux gene isolated from a plasmid in Photobacterium damselae.
ARO:3003923	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	Escherichia coli	oqxB	resistance-nodulation-cell division (RND) antibiotic efflux pump	diaminopyrimidine antibiotic | fluoroquinolone antibiotic | glycylcycline | nitrofuran antibiotic | tetracycline antibiotic	antibiotic efflux	oqxB	RND efflux pump conferring resistance to fluoroquinolone.
ARO:3003949	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0		efrB	ATP-binding cassette (ABC) antibiotic efflux pump	fluoroquinolone antibiotic | macrolide antibiotic | rifamycin antibiotic	antibiotic efflux	efrB	efrB is a part of the EfrAB efflux pump, and both efrA and efrB are necessary to confer multidrug resistance.
ARO:3003950	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	Escherichia coli str. K-12 substr. MG1655	msbA	ATP-binding cassette (ABC) antibiotic efflux pump	nitroimidazole antibiotic	antibiotic efflux	msbA	MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A, a major component of the bacterial outer cell membrane, and is the only bacterial ABC transporter that is essential for cell viability.
ARO:3003955	0.0	0.0	0.0	0.0	0.0	0.0	2.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Mycobacterium tuberculosis H37Rv	efpA	major facilitator superfamily (MFS) antibiotic efflux pump	isoniazid-like antibiotic | rifamycin antibiotic	antibiotic efflux	efpA	efpA is an MFS transporter found in Mycobacterium tuberculosis.
ARO:3003987	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Paenibacillus sp. LC231	VatI	streptogramin vat acetyltransferase	streptogramin A antibiotic | streptogramin antibiotic	antibiotic inactivation	VatI	Streptogramin A acetyltransferase found in Paenibacillus sp. LC231, isolated from Lechuguilla Cave, NM, USA. Confers resistance to streptogramin A antibiotics. Described by Pawlowski et al. 2016.
ARO:3004074	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	1.0	0.0	0.0	Pseudomonas aeruginosa PAO1	MuxB	resistance-nodulation-cell division (RND) antibiotic efflux pump	aminocoumarin antibiotic | macrolide antibiotic | monobactam | tetracycline antibiotic	antibiotic efflux	MuxB	MuxB is one of the two necessary RND components in the Pseudomonas aeruginosa efflux pump system MuxABC-OpmB.
ARO:3004075	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	Pseudomonas aeruginosa PAO1	MuxC	resistance-nodulation-cell division (RND) antibiotic efflux pump	aminocoumarin antibiotic | macrolide antibiotic | monobactam | tetracycline antibiotic	antibiotic efflux	MuxC	MuxC is one of the two necessary RND components of the MuxABC-OpmB efflux pumps system in Pseudomonas aeruginosa.
ARO:3004480	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	Bifidobacterium adolescentis	Bifidobacterium adolescentis rpoB mutants conferring resistance to rifampicin	rifamycin-resistant beta-subunit of RNA polymerase (rpoB)	peptide antibiotic | rifamycin antibiotic	antibiotic target alteration | antibiotic target replacement	Bado_rpoB_RIF	Bifidobacterium are antibiotic resistant probiotics are prescribed to upkeep the population beneficial bacteria in the gut microbiome. However, horizontal gene transfer among gut microbes could create harmful antibiotic-resistant pathogenic bacteria, such as Mycobacterium tuberculosis. Lokesh et al. analyzed Bifidobacterium antitubercular drug resistance and mutations in rpoB. They found that B. animalis, B. longum and B. adolescentis showed considerable resistance to pyrazinamide, isoniazid, and streptomycin, while B. adolescentis had mutations both in the rifampicin (RIF) pocket and in regions outside the pockets, and also showed considerable resistance to RIF.
ARO:3004596	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Rhodococcus hoagii	erm(46)	Erm 23S ribosomal RNA methyltransferase	lincosamide antibiotic | macrolide antibiotic | streptogramin antibiotic	antibiotic target alteration	erm(46)	erm(46) is transferable determinant that confers resistance to macrolides.
ARO:3004600	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Riemerella anatipestifer RA-CH-2	LnuH	lincosamide nucleotidyltransferase (LNU)	lincosamide antibiotic	antibiotic inactivation	LnuH	LnuH is a lincosamide nucleotidyltransferase transferase.
ARO:3004639	1.0	0.0	6.0	1.0	0.0	2.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	2.0	1.0	0.0	1.0	2.0	1.0	0.0	0.0	0.0	0.0	1.0	0.0	1.0	3.0	1.0	0.0	0.0	0.0	Corynebacterium striatum	Corynebacterium striatum tetA	major facilitator superfamily (MFS) antibiotic efflux pump	penicillin beta-lactam | tetracycline antibiotic	antibiotic efflux	Cstr_tetA	The tetAB genes of the Corynebacterium striatum R-plasmid encode an ABC transporter and confer tetracycline, oxytetracycline, and oxalic resistance.
ARO:3004692	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Pseudomonas aeruginosa	aadA10	ANT(3'')	aminoglycoside antibiotic	antibiotic inactivation	aadA10	aadA10 is a aminoglycoside nucleotidyltransferase gene encoded by plasmids in P. aeruginosa.
ARO:3004704	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Escherichia coli	aadA8b	ANT(3'')	aminoglycoside antibiotic	antibiotic inactivation	aadA8b	aadA8b is an aminoglycoside nucleotidyltransferase gene encoded by plasmids in E. coli; can be created by a recombination event  between aadA1 and aadA2.
ARO:3004809	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0		GOB-2	GOB beta-lactamase	carbapenem | cephalosporin | penicillin beta-lactam	antibiotic inactivation	GOB-2	GOB-2 is class B beta-lactamase gene found in Elizabethkingia meningoseptica.
ARO:3005061	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Cupriavidus gilardii	AAC(3)-IVb	AAC(3)	aminoglycoside antibiotic	antibiotic inactivation	AAC(3)-IVb	A novel aminoglycoside resistance gene identified from Cupriavidus gilardii; AAC(3)-IVb / aacC10 is an aminoglycoside-3-N-acetyltransferase gene which confers resistance to gentamicin and tobramycin.
ARO:3005069	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	Pseudomonas aeruginosa	rsmA	resistance-nodulation-cell division (RND) antibiotic efflux pump	diaminopyrimidine antibiotic | fluoroquinolone antibiotic | phenicol antibiotic	antibiotic efflux	rsmA	rsmA is a gene that regulates virulence of Pseudomonas aeruginosa. However, its negative effect on MexEF-OprN overexpression has been noted to confer resistance to various antibiotics. It's Escherichia coli homolog is csrA.
ARO:3005087	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	1.0	0.0	0.0	0.0	2.0	0.0	0.0	1.0	1.0	0.0	0.0	1.0	0.0	0.0	1.0	0.0	Macrococcus canis	msrF	msr-type ABC-F protein	macrolide antibiotic | streptogramin antibiotic	antibiotic target protection	msrF	msrF is an ABC-F binding cassette ribosomal protection protein. It confers resistance to macrolide antibiotics.
ARO:3005088	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Macrococcus canis	msrH	msr-type ABC-F protein	macrolide antibiotic | streptogramin antibiotic	antibiotic target protection	msrH	msrH is a ABC-F binding cassette ribosomal protection protein. It confers resistance to macrolide antibiotics.
ARO:3005091	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Riemerella anatipestifer RA-GD	RanA	ATP-binding cassette (ABC) antibiotic efflux pump	aminoglycoside antibiotic	antibiotic efflux	RanA	RanA is a part of the RanARanB ABC-type efflux system. Alongside RanB, it confers resistance to aminoglycoside antibiotics.
ARO:3005689	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Elizabethkingia anophelis	GOB-40	GOB beta-lactamase	carbapenem | cephalosporin | penicillin beta-lactam	antibiotic inactivation	GOB-40	GOB-40 is a GOB beta-lactamase.
ARO:3005692	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Elizabethkingia anophelis	GOB-43	GOB beta-lactamase	carbapenem | cephalosporin | penicillin beta-lactam	antibiotic inactivation	GOB-43	GOB-43 is a GOB beta-lactamase.
ARO:3005694	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Elizabethkingia anophelis	GOB-45	GOB beta-lactamase	carbapenem | cephalosporin | penicillin beta-lactam	antibiotic inactivation	GOB-45	GOB-45 is a GOB beta-lactamase.
ARO:3007042	0.0	1.0	0.0	1.0	0.0	0.0	0.0	1.0	1.0	0.0	0.0	0.0	0.0	1.0	1.0	0.0	0.0	1.0	0.0	1.0	0.0	3.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Macrococcus canis	msr(G)	msr-type ABC-F protein	macrolide antibiotic | streptogramin antibiotic	antibiotic target protection	msr(G)	msr(G) is a part of the msr subfamily of ABC-F ribosomal protection proteins.
ARO:3007043	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Streptococcus pyogenes	msr(I)	msr-type ABC-F protein	macrolide antibiotic | phosphonic acid antibiotic | streptogramin antibiotic	antibiotic target protection	msr(I)	msr(I) is part of the msr subfamily of ABC-F ribosomal protection proteins.
ARO:3007492	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	uncultured bacterium	tet(62)	major facilitator superfamily (MFS) antibiotic efflux pump	tetracycline antibiotic	antibiotic efflux	tet(62)	A novel tetA-type efflux pump.
ARO:3007659	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Mycobacterium tuberculosis H37Rv	putative nickel/cobalt transporter	metal transporters with antibiotic efflux	aminoglycoside antibiotic | fluoroquinolone antibiotic | isoniazid-like antibiotic	antibiotic efflux	Rv2856	Ectopic expression of NiCoT in Escherichia coli CS109 resulted in the increase of intracellular nickel uptake with enhanced tolerance towards several antibiotics when NiCoT was overexpressed in E. coli and Mycobacterium smegmatis. The presence of a sub-inhibitory dose of nickel resulted in the manifestation of low-level tolerance towards these drugs.
ARO:3008081	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	Riemerella anatipestifer	BMHC-1	BMHC beta-lactamase	carbapenem	antibiotic inactivation	BMHC-1	Subclass B1 metallo-beta-lactamase BMHC-1.