# CCycDB Gene Family MAG.C2.12 MAG.T11.11 MAG.T13.20 MAG.T13.85 MAG.T13.59 MAG.T11.14 MAG.T11.1 MAG.T11.24 MAG.T11.25 MAG.T11.56 MAG.T11.59 MAG.T11.77 MAG.T13.83 MAG.T13.71 MAG.T12.46 MAG.T13.57 MAG.T13.60 MAG.T12.69 MAG.T11.57 MAG.T13.90 MAG.T21.39 MAG.T22.36 MAG.T22.49 MAG.T23.24 MAG.T23.71 MAG.T23.60 MAG.T11.72 MAG.T13.29 MAG.T12.26 MAG.T23.20 MAG.T21.70 MAG.T22.48 MAG.T21.30 Category subCategoryI subCategoryII Description RegX3 2.0 2.0 1.0 1.0 1.0 5.0 1.0 1.0 1.0 6.0 1.0 1.0 1.0 0.0 3.0 1.0 1.0 3.0 3.0 5.0 2.0 1.0 3.0 1.0 1.0 0.0 2.0 8.0 4.0 7.0 2.0 3.0 1.0 Transport | Organic Biosynthesis Two-component system | Inorganic phosphorus Two-component system Two-component system, OmpR family, response regulator RegX3 SenX3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport | Organic Biosynthesis Two-component system | Inorganic phosphorus Two-component system Two-component system, OmpR family, sensor histidine kinase SenX3 [Mn]sod 0.0 1.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 1.0 2.0 0.0 1.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics Lignin Superoxide dismutase [Mn] aapJ 0.0 0.0 0.0 0.0 0.0 4.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 Transport ABC transport ABC transport General L-amino acid-binding periplasmic protein aapM 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 Transport ABC transport ABC transport General L-amino acid transport system permease protein aapP 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 1.0 0.0 Transport ABC transport ABC transport General L-amino acid transport ATP-binding protein aapQ 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Transport ABC transport ABC transport General L-amino acid transport system permease protein aarC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Carbohydrate Citrate cycle | Pyruvate Succinyl-CoA:acetate CoA-transferase aauA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 aauB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 accA 1.0 1.0 1.0 0.0 1.0 2.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 2.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Carbohydrate | CO2 | Lipid Pyruvate | 3-Hydroxypropionate Bicycle | 3-Hydroxypropionate/4-Hydroxybutyrate Cycle | Fatty acid Acetyl-CoA carboxylase carboxyltransferase accB 0.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Carbohydrate | CO2 | Lipid Pyruvate | 3-Hydroxypropionate Bicycle | 3-Hydroxypropionate/4-Hydroxybutyrate Cycle | Fatty acid Acetyl-CoA carboxylase accC 2.0 1.0 2.0 2.0 1.0 3.0 2.0 1.0 2.0 1.0 1.0 1.0 1.0 2.0 2.0 1.0 1.0 1.0 2.0 2.0 1.0 1.0 2.0 1.0 1.0 1.0 1.0 3.0 1.0 1.0 2.0 2.0 2.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Carbohydrate | CO2 | Lipid Pyruvate | 3-Hydroxypropionate Bicycle | 3-Hydroxypropionate/4-Hydroxybutyrate Cycle | Fatty acid Acetyl-CoA carboxylase|Biotin carboxylase accD 1.0 1.0 1.0 1.0 1.0 2.0 1.0 2.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Carbohydrate | CO2 | Lipid Pyruvate | 3-Hydroxypropionate Bicycle | 3-Hydroxypropionate/4-Hydroxybutyrate Cycle | Fatty acid Acetyl-CoA carboxylase carboxyl transferase accD6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Carbohydrate | CO2 | Lipid Pyruvate | 3-Hydroxypropionate Bicycle | 3-Hydroxypropionate/4-Hydroxybutyrate Cycle | Fatty acid Acetyl-CoA/propionyl-CoA carboxylase carboxyl transferase subunit acdA 1.0 2.0 4.0 3.0 3.0 14.0 2.0 0.0 1.0 13.0 3.0 5.0 3.0 3.0 3.0 0.0 3.0 0.0 3.0 5.0 5.0 4.0 3.0 0.0 0.0 0.0 1.0 3.0 7.0 1.0 0.0 5.0 3.0 Organic Degration | Carbon Release | Organic Biosynthesis Carbohydrate | CH4 Monosaccharide | Aceticlastic methanogenesis | Pyruvate | Glycolysis Acetate-CoA ligase (ADP-forming) acdB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Degration | Carbon Release | Organic Biosynthesis Carbohydrate | CH4 Monosaccharide | Aceticlastic methanogenesis | Pyruvate | Glycolysis Acetate-CoA ligase (ADP-forming) aceA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 aceE 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 1.0 2.0 0.0 2.0 0.0 Organic Degration | Carbon Release | Organic Biosynthesis Carbohydrate | CO2 Monosaccharide | CO2 | Fermentation | Pyruvate Pyruvate dehydrogenase E1 component ackA 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 1.0 0.0 1.0 2.0 0.0 0.0 0.0 2.0 1.0 1.0 1.0 0.0 0.0 Organic Degration | Carbon Release | Organic Biosynthesis Carbohydrate | CH4 Aceticlastic methanogenesis | Fermentation | Pyruvate Acetate kinase aclB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 Carbon Fixation CO2 Reductive tricarboxylic acid cycle ATP citrate lyase acmA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 acmB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 acnB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 Organic Degration Carbohydrate Citrate cycle | Glyoxylate cycle Aconitate hydratase acnD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 acoA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 3.0 1.0 0.0 0.0 1.0 2.0 0.0 Organic Degration Xenobiotics Herbicide Acetoin:2,6-dichlorophenolindophenol oxidoreductase acoB 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 2.0 0.0 Organic Degration Xenobiotics Herbicide Acetoin:2,6-dichlorophenolindophenol oxidoreductase acpH 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Cofactor Coenzyme Acyl carrier protein phosphodiesteras acpP 1.0 2.0 1.0 4.0 6.0 3.0 1.0 2.0 3.0 1.0 2.0 3.0 5.0 2.0 1.0 3.0 2.0 4.0 1.0 0.0 3.0 1.0 1.0 2.0 1.0 1.0 2.0 1.0 0.0 3.0 2.0 2.0 1.0 Organic Degration Secondary metabolite | Lipid | Antibiotic Secondary metabolite | Antibiotic | Fatty acid Acyl carrier protein acpS 0.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 3.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 2.0 0.0 Organic Degration Cofactor Coenzyme Holo-[acyl-carrier-protein] synthase acrC 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 acs 1.0 0.0 0.0 1.0 0.0 0.0 1.0 1.0 1.0 2.0 0.0 1.0 0.0 0.0 1.0 1.0 0.0 1.0 0.0 1.0 2.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Organic Degration | Carbon Release | Organic Biosynthesis Carbohydrate | CH4 Aceticlastic methanogenesis | Pyruvate | Glycolysis Acetyl-CoA synthetase acsA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 Carbon Fixation | Carbon Release CO2 | CH4 | CO Reductive acetyl-CoA pathway | CO | CO, Oxidized ferredoxin <=> CO2, Reduced ferredoxin | CO2 | Aceticlastic methanogenesis Carbon monoxide dehydrogenase acsB 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Fixation | Carbon Release CO2 | CO CO2 | Acetyl-CoA <=> CO, CoA | Reductive acetyl-CoA pathway | CO Acetyl-CoA synthase acsF 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Porphyrin Magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase actIII 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Transformation | Organic Biosynthesis Secondary metabolite | Lipid | Antibiotic Polyketide | Tetracycline Ketoacyl reductase acuI 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 2.0 1.0 1.0 0.0 0.0 0.0 Organic Degration Organic sulfur cycle | DMSP catabolic pathway Ancillary genes | Organic sulfur transformation Acrylyl-CoA reductase AcuI acyP 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Carbohydrate | Aromatics Aromatics | Fermentation | Pyruvate Acylphosphatase adc 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 Organic Degration | Carbon Release | Organic Biosynthesis CO2 | Amino acid | Cofactor Aromatic | CO2 | Vitamin B | beta-amino acid Acetoacetate decarboxylase|Acylphosphatase add 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor | Nucleotide Purine | Vitamin K | Coenzyme Aminodeoxyfutalosine deaminase|Adenosine deaminase adh 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Degration | Organic Biosynthesis Carbohydrate | Aromatics | Lipid | Cofactor Aromatics | Fermentation | Vitamin A | Glycolysis | Fatty acid | Pyruvate Alcohol dehydrogenase adh1 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Transformation | Organic Degration Xenobiotics Lignin Alcohol dehydrogenase adh3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 adhC 0.0 0.0 2.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 1.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 Organic Degration | Organic Biosynthesis Carbohydrate | Aromatics | Lipid | Cofactor Aromatics | Vitamin A | Fatty acid | Glycolysis | Pyruvate NADP-dependent alcohol dehydrogenase adk 2.0 1.0 2.0 2.0 2.0 2.0 1.0 3.0 1.0 1.0 2.0 2.0 3.0 2.0 2.0 1.0 3.0 2.0 1.0 2.0 1.0 2.0 2.0 1.0 1.0 0.0 2.0 1.0 0.0 3.0 1.0 1.0 3.0 Organic Degration | Organic Biosynthesis Organophosphorus compound | Cofactor | Nucleotide Purine | Vitamin B | Purine metabolism Adenylate kinase aftA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Glycan Galactoarabinan | Lipoarabinomannan Galactan 5-O-arabinofuranosyltransferase aftB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Biosynthesis Glycan Glycolipid | Galactoarabinan | Lipoarabinomannan Terminal beta-(1->2)-arabinofuranosyltransferase aftC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Biosynthesis Glycan Glycolipid | Galactoarabinan | Lipoarabinomannan Alpha-(1->3)-arabinofuranosyltransferase afuB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Transport ABC transport ABC transport Iron(III) transport system permease protein aglG 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Transport ABC transport ABC transport Alpha-glucoside transport system permease protein aglK 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Transport ABC transport ABC transport Alpha-glucoside transport ATP-binding protein aguA 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Carbohydrate | Amino acid Pectin | Alpha-galactans | Xylan | Hemicellulose | Cationic Agmatine deiminase aguB 0.0 0.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Release | Organic Biosynthesis CO2 | Amino acid CO2 | Cationic N-carbamoylputrescine amidase ahbD 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Release | Organic Biosynthesis CO2 | Cofactor CO2 | Porphyrin AdoMet-dependent heme synthase ahr 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Degration | Organic Biosynthesis Carbohydrate Pyruvate | Glycolysis Alcohol/geraniol dehydrogenase (NADP+) ala 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Carbohydrate Pyruvate Alanine dehydrogenase alaA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Amino acid Aliphatic | Anionic | Cationic Glutamate-pyruvate aminotransferase AlaA aldC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Carbon Release CO2 CO2 Alpha-acetolactate decarboxylase aldH 0.0 1.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 2.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Carbohydrate Monosaccharide | Plastics NADP-dependent fatty aldehyde dehydrogenase algA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Glycan | Carbohydrate Monosaccharide | O-linked Alginate biosynthesis protein algD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport | Organic Degration Carbohydrate | Two-component system Monosaccharide | Two-component system GDP-mannose 6-dehydrogenase aliB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Degration Aromatics Aromatics Cyclohexanecarboxyl-CoA dehydrogenase alkB1 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics Plastics Alkane 1-monooxygenase alkB2 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics Plastics Alkane 1-monooxygenase alkT 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 Organic Degration Lipid Fatty acid Rubredoxin-NAD(+) reductase alr 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Amino acid D-Amino acid Alanine racemase amgK 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 amn 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Nucleotide Purine AMP nucleosidase ansA 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 Organic Degration | Transport | Organic Transformation | Organic Biosynthesis Two-component system | Amino acid L-Amino acid | Two-component system | Anionic | Cationic | D-Amino acid | Aliphatic L-asparaginase ansB 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration | Transport | Organic Transformation | Organic Biosynthesis Nitrogen cycle | Amino acid | Two-component system Two-component system | Anionic | Organic degradation and synthesis | Cationic | D-Amino acid | Aliphatic L-asparaginase aofH 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Amino acid Aromatic | Aliphatic Flavin-containing monoamine oxidase aor 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics | Carbohydrate Monosaccharide | Lignin | Pentose phosphate Aldehyde ferredoxin oxidoreductase aotP 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Transport ABC transport ABC transport Arginine/ornithine transport ATP-binding protein apcC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Fixation | Organic Transformation | Organic Degration Xenobiotics | Photosynthesis Photosynthesis proteins | Lignin Phycobilisome 7.8 kDa linker polypeptide, allophycocyanin-associated, core apgM 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Carbohydrate | Amino acid | CH4 | Methane-aerobic Aliphatic | Aerobic oxidation | serine cycle | Glycolysis 2,3-bisphosphoglycerate-independent phosphoglycerate mutase aprA 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Degration Inorganic sulfur transformation Dissimilatory sulfur reduction and oxidation Adenylylsulfate reductase, subunit A apt 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Nucleotide Purine Adenine phosphoribosyltransferase araB 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Carbohydrate Monosaccharide Ribulokinase araC 0.0 0.0 0.0 0.0 0.0 3.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 2.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 4.0 0.0 3.0 0.0 araD 0.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Carbohydrate Monosaccharide L-ribulose-5-phosphate 4-epimerase araD-K01683 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Carbohydrate Monosaccharide Arabinonate dehydratase araG 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Transport ABC transport ABC transport L-arabinose transport ATP-binding protein arcA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Amino acid Cationic Arginine deiminase arcC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Amino acid | Nucleotide Purine | Cationic Carbamate kinase arg 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Amino acid Cationic Arginase argA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 1.0 0.0 0.0 1.0 0.0 Organic Biosynthesis Amino acid Cationic Amino-acid acetyltransferase argB 1.0 1.0 1.0 0.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 1.0 0.0 Organic Biosynthesis Amino acid L-Amino acid | Cationic Amino-acid acetyltransferase argC 1.0 1.0 1.0 0.0 1.0 2.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 Organic Biosynthesis Amino acid L-Amino acid | Cationic N-acetyl-gamma-glutamyl-phosphate reductase argD 1.0 2.0 2.0 1.0 2.0 1.0 2.0 0.0 1.0 1.0 1.0 1.0 0.0 2.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 2.0 0.0 0.0 0.0 1.0 1.0 2.0 1.0 2.0 1.0 0.0 Organic Biosynthesis Amino acid L-Amino acid | Cationic Acetylornithine aminotransferase argE 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Amino acid L-Amino acid | Cationic Acetylornithine deacetylase argF 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Amino acid Cationic Ornithine carbamoyltransferase argG 1.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 2.0 0.0 0.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 Organic Degration | Organic Biosynthesis Amino acid Anionic | Cationic Argininosuccinate synthase argH 1.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 Organic Degration | Organic Biosynthesis Amino acid Cationic Argininosuccinate lyase argJ 1.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 Organic Biosynthesis Amino acid Cationic Arginine biosynthesis bifunctional protein argO 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Amino acid Cationic Arginine exporter protein ArgO arnA 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Release CO2 CO2 UDP-glucuronic acid dehydrogenase|UDP-4-keto-hexauronic acid decarboxylating arnC 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 aroB 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 aroC 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 2.0 1.0 1.0 1.0 1.0 1.0 0.0 aroE 1.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 2.0 1.0 5.0 1.0 2.0 0.0 aroG 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Amino acid Aromatic Phospho-2-dehydro-3-deoxyheptonate aldolase aroK 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 aroQ 1.0 1.0 1.0 1.0 1.0 2.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 artQ 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Transport ABC transport ABC transport Arginine ABC transporter permease protein|Arginine transport system permease protein aruH 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Amino acid Cationic Arginine--pyruvate transaminase aruI 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Carbon Release | Organic Biosynthesis CO2 | Amino acid CO2 | Cationic 2-ketoarginine decarboxylase asd 1.0 1.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Organic Biosynthesis Amino acid L-Amino acid | Alcohol | Anionic | S side-chain Aspartate-semialdehyde dehydrogenase asnB 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 2.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 1.0 1.0 1.0 2.0 0.0 1.0 Organic Degration | Organic Biosynthesis Nitrogen cycle | Amino acid Anionic | Organic degradation and synthesis Asparagine synthetase B [glutamine-hydrolyzing] aspA-K01744 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 Organic Degration Amino acid L-Amino acid Aspartate ammonia-lyase aspB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Amino acid | Secondary metabolite | Antibiotic S side-chain | Anionic | Antibiotic | Secondary metabolite | Cationic | Aromatic Aspartate aminotransferase aspC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Amino acid | Secondary metabolite | Antibiotic S side-chain | Anionic | Antibiotic | Secondary metabolite | Cationic | Aromatic Aspartate aminotransferase astD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Amino acid Cationic N-succinylglutamate 5-semialdehyde dehydrogenase atpA 2.0 2.0 0.0 2.0 1.0 1.0 1.0 2.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 2.0 1.0 1.0 2.0 1.0 1.0 4.0 2.0 1.0 1.0 0.0 1.0 1.0 2.0 0.0 1.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Carbohydrate | Photosynthesis Photosynthetic phosphorylation | ATPase | Oxidative phosphorylation ATP synthase subunit alpha atpB 1.0 1.0 1.0 1.0 1.0 2.0 1.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 0.0 2.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Carbohydrate | Photosynthesis Photosynthetic phosphorylation | ATPase | Oxidative phosphorylation ATP synthase subunit a atpC 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 2.0 1.0 1.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Carbohydrate | Photosynthesis Photosynthetic phosphorylation | ATPase | Oxidative phosphorylation ATP synthase epsilon chain atpD 1.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 0.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Carbohydrate | Photosynthesis Photosynthetic phosphorylation | ATPase | Oxidative phosphorylation ATP synthase subunit beta atpE 2.0 1.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 2.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Carbohydrate | Photosynthesis Photosynthetic phosphorylation | ATPase | Oxidative phosphorylation ATP synthase subunit c atpF 0.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 2.0 0.0 0.0 0.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Carbohydrate | Photosynthesis Photosynthetic phosphorylation | ATPase | Oxidative phosphorylation ATP synthase subunit b atpG 1.0 1.0 1.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Carbohydrate | Photosynthesis Photosynthetic phosphorylation | ATPase | Oxidative phosphorylation ATP synthase gamma chain atpH 0.0 1.0 1.0 0.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Carbohydrate | Photosynthesis Photosynthetic phosphorylation | ATPase | Oxidative phosphorylation ATP synthase subunit delta atpI 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration Carbohydrate Oxidative phosphorylation V-type ATP synthase|ATP synthase subunit a atzB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics Herbicide Hydroxydechloroatrazine ethylaminohydrolase bacA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport | Carbon Release | Organic Transformation | Organic Degration Glycan | Antibiotic | CO2 | Secondary metabolite | ABC transport Polypeptide antibiotic | Antibiotic | Peptidoglycan | CO2 | Secondary metabolite | ABC transport Prephenate decarboxylase badH 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Degration Xenobiotics | Aromatics Aromatics | Lignin 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase badI 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Degration Xenobiotics | Aromatics Aromatics | Lignin 2-ketocyclohexane-carboxyl-CoA hydrolase badK 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 2.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Aromatics Aromatics | Lignin Cyclohex-1-ene-1-carboxyl-CoA hydratase bbsA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics | Aromatics Aromatics | Lignin Benzoylsuccinyl-CoA thiolase bbsB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics | Aromatics Aromatics | Lignin Benzoylsuccinyl-CoA thiolase bbsC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics | Aromatics Aromatics | Lignin 2-[hydroxy(Phenyl)methyl]-succinyl-CoA dehydrogenase bbsG 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics | Aromatics Aromatics | Lignin (R)-benzylsuccinyl-CoA dehydrogenase bccA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Carbohydrate | CO2 | Lipid Pyruvate | 3-Hydroxypropionate Bicycle | 3-Hydroxypropionate/4-Hydroxybutyrate Cycle | Fatty acid Acetyl-CoA/propionyl-CoA carboxylase bchC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Porphyrin 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase bchD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Porphyrin Mg-protoporphyrin IX chelatase bchE 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Porphyrin Anaerobic magnesium-protoporphyrin IX monomethyl ester cyclase bchF 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Porphyrin 2-vinyl bacteriochlorophyllide hydratase bchG 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Porphyrin Bacteriochlorophyll synthase bchH 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Porphyrin Magnesium-chelatase bchI 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Porphyrin Magnesium-chelatase bchP 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 Organic Biosynthesis Secondary metabolite | Cofactor Terpenoid | Porphyrin Geranylgeranyl reductase bchX 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Porphyrin Chlorophyllide reductase bchY 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Porphyrin Chlorophyllide reductase bchZ 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Porphyrin Chlorophyllide reductase bclA 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics Lignin Benzoate--CoA ligase bcpA 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Release | Organic Biosynthesis Carbohydrate | CO2 CO2 | Pyruvate Oxaloacetate decarboxylase bdhA 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 2.0 0.0 benA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics | Aromatics Aromatics | Lignin Benzoate dioxygenase, alpha subunit benB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics | Aromatics Aromatics | Lignin Benzoate dioxygenase, beta subunit benC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics | Aromatics Aromatics | Lignin Benzoate 1,2-dioxygenase electron transfer component benD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics | Aromatics Aromatics | Lignin 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase benE 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 Organic Transformation | Organic Degration Xenobiotics Lignin Benzoate membrane transport protein benK 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 Organic Transformation | Organic Degration Xenobiotics Lignin Benzoate MFS transporter benM 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Transformation | Organic Degration Xenobiotics Lignin HTH-type transcriptional regulator betA 0.0 0.0 0.0 0.0 0.0 12.0 0.0 0.0 0.0 1.0 0.0 2.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 1.0 0.0 0.0 0.0 0.0 0.0 3.0 2.0 0.0 2.0 0.0 Organic Degration Organic sulfur cycle Organic sulfur transformation Oxygen-dependent choline dehydrogenase betB 0.0 1.0 1.0 1.0 1.0 4.0 1.0 1.0 0.0 7.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 4.0 3.0 0.0 1.0 0.0 1.0 1.0 4.0 2.0 7.0 0.0 3.0 1.0 Organic Degration Organic sulfur cycle Organic sulfur transformation NAD/NADP-dependent betaine aldehyde dehydrogenase betC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 7.0 0.0 4.0 0.0 0.0 2.0 0.0 3.0 0.0 0.0 1.0 2.0 0.0 1.0 1.0 0.0 1.0 0.0 Organic Degration Organic sulfur cycle Organic sulfur transformation Choline-sulfatase bfr 1.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 2.0 0.0 0.0 Organic Biosynthesis Cofactor Porphyrin Bacterioferritin bglX 0.0 0.0 3.0 2.0 0.0 0.0 1.0 0.0 1.0 0.0 2.0 0.0 0.0 2.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics | Carbohydrate | Secondary metabolite | Antibiotic Arabinose | Chitin | Pectin | Antibiotic | Arabinan | Starch | Xylan | Beta-galactans | Xyloglucan | Secondary metabolite | Hemicellulose | Lignin | Beta-mannan | Cellulose | Disaccharide Beta-glucosidase bioA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B Adenosylmethionine-8-amino-7-oxononanoate aminotransferase bioB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B Biotin synthase bioC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 2.0 1.0 0.0 0.0 1.0 0.0 Organic Biosynthesis Cofactor Vitamin B Malonyl-[acyl-carrier protein] O-methyltransferase bioD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Fixation | Carbon Release | Organic Biosynthesis CO2 | Cofactor CO2 | Diaminononanoate, CO2 <=> Phosphate, Dethiobiotin | Vitamin B Dethiobiotin synthetase bioF 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 3.0 1.0 0.0 1.0 0.0 0.0 Carbon Release | Organic Biosynthesis CO2 | Cofactor CO2 | Vitamin B 8-amino-7-oxononanoate synthase bioH 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B Pimeloyl-[acyl-carrier protein] methyl ester esterase bioY 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 Transport ABC transport ABC transport Biotin transporter birA 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Cofactor Vitamin B Biotin--[acetyl-CoA-carboxylase] ligase biuH 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration Xenobiotics Herbicide Biuret hydrolase bkdA1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Release CO2 CO2 2-oxoisovalerate dehydrogenase subunit alpha|3-methyl-2-oxobutanoate dehydrogenase subunit alpha bkdA2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Release CO2 CO2 2-oxoisovalerate dehydrogenase subunit alpha|3-methyl-2-oxobutanoate dehydrogenase subunit alpha bktB 0.0 1.0 1.0 1.0 2.0 0.0 2.0 1.0 2.0 1.0 2.0 1.0 1.0 2.0 2.0 0.0 2.0 0.0 2.0 0.0 2.0 1.0 2.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 2.0 Organic Degration Xenobiotics Lignin beta-ketothiolase bktL 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics Lignin Putative beta-ketothiolase blt 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics Lignin Benzoylacetyl-CoA thiolase bluB 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 1.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Cofactor Vitamin B 5,6-dimethylbenzimidazole synthase boxB 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Aromatics Aromatics | Lignin Benzoyl-CoA oxygenase component boxC 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Aromatics Aromatics | Lignin Benzoyl-CoA-dihydrodiol lyase boxD 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Aromatics Aromatics | Lignin 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase bphC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics Organic pollutant | Lignin Biphenyl-2,3-diol 1,2-dioxygenase bphF 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics Organic pollutant Biphenyl dioxygenase system ferredoxin subunit bphH 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics | Aromatics Organic pollutant | Aromatics | Lignin 2-hydroxypenta-2,4-dienoate hydratase braD 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport Two-component system | ABC transport Two-component system | ABC transport High-affinity branched-chain amino acid transport system permease protein braE 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport Two-component system | ABC transport Two-component system | ABC transport High-affinity branched-chain amino acid transport system permease protein bsdC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Carbon Release | Organic Degration CO2 | Aromatics CO2 | Aromatics Phenolic acid decarboxylase bshB1 0.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 btaA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Transformation | Organic Biosynthesis Lipid Fatty acid S-adenosylmethionine-diacylglycerol 3-amino-3-carboxypropyl transferase btuB 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport | Organic Biosynthesis ABC transport | Cofactor Vitamin B | ABC transport Vitamin B12 transporter BtuB btuC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 Transport | Organic Biosynthesis ABC transport | Cofactor Vitamin B | ABC transport Vitamin B12 import system permease protein BtuC btuF 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Transport | Organic Biosynthesis ABC transport | Cofactor Vitamin B | ABC transport Vitamin B12-binding protein btuR 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B | Porphyrin Cob(I)alamin adenosyltransferase budC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 bzdW 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics Lignin Putative dienoyl-CoA hydratase bztB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Transport ABC transport ABC transport Glutamate/glutamine/aspartate/asparagine transport system permease protein bztC 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport ABC transport ABC transport Glutamate/glutamine/aspartate/asparagine transport system permease protein bztD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 1.0 0.0 Transport ABC transport ABC transport Glutamate/glutamine/aspartate/asparagine transport ATP-binding protein calB 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 1.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics Lignin Coniferyl aldehyde dehydrogenase can 0.0 1.0 1.0 1.0 2.0 1.0 1.0 0.0 1.0 0.0 2.0 1.0 1.0 2.0 1.0 1.0 1.0 0.0 1.0 0.0 0.0 1.0 2.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 0.0 2.0 2.0 Carbon Release CO2 CO2 Carbonic anhydrase carA-EC6.3.5.5 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 Organic Biosynthesis Amino acid Anionic Carbamoyl-phosphate synthase carB 1.0 1.0 0.0 2.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 2.0 1.0 2.0 1.0 2.0 Carbon Release | Organic Degration CO2 | Secondary metabolite | Antibiotic CO2 | Secondary metabolite | Antibiotic Carbamoyl-phosphate synthase cat 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 1.0 0.0 2.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 Organic Transformation | Organic Degration Xenobiotics Lignin Catalase catC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Degration Xenobiotics | Aromatics Aromatics | Lignin Muconolactone Delta-isomerase catE 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 1.0 0.0 0.0 Organic Degration Xenobiotics | Aromatics Organic pollutant | Aromatics | Lignin Catechol-2,3-dioxygenase catR 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration Xenobiotics Lignin HTH-type transcriptional regulator cbbA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 Carbon Fixation | Organic Biosynthesis CO2 | Photosynthesis Calvin cycle | Calvin-Benson-Bassham Cycle Fructose-1,6-bisphosphate aldolase cbbE 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 Carbon Fixation | Organic Biosynthesis CO2 | Photosynthesis Calvin cycle | Calvin-Benson-Bassham Cycle Ribulose-phosphate 3-epimerase cbbG 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 Carbon Fixation | Organic Biosynthesis CO2 | Photosynthesis Calvin cycle | Calvin-Benson-Bassham Cycle Glyceraldehyde-3-phosphate dehydrogenase cbbL 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Fixation | Carbon Release | Organic Biosynthesis CO2 | Photosynthesis CO2 | Calvin cycle | Calvin-Benson-Bassham Cycle Ribulose bisphosphate carboxylase cbbP 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 Carbon Fixation | Organic Biosynthesis CO2 | Photosynthesis Calvin cycle | Calvin-Benson-Bassham Cycle Phosphoribulokinase cbbS 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Fixation | Carbon Release | Organic Biosynthesis CO2 | Photosynthesis CO2 | Calvin cycle | Calvin-Benson-Bassham Cycle Ribulose bisphosphate carboxylase cbbT 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Carbon Fixation | Organic Biosynthesis CO2 | Photosynthesis Calvin cycle | Calvin-Benson-Bassham Cycle Transketolase cbbX 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Fixation | Organic Biosynthesis CO2 | Photosynthesis Calvin cycle | Calvin-Benson-Bassham Cycle Torulene oxygenas|Rubisco expression protein cbdA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Carbon Release | Organic Degration CO2 | Aromatics CO2 | Aromatics 2-halobenzoate 1,2-dioxygenase cbiA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 1.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B Cobyrinate a,c-diamide synthase cbiC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B Cobalt-precorrin-8 methylmutase cbiD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 2.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B | Porphyrin Cobalt-precorrin-5B C(1)-methyltransferase cbiF 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B | Porphyrin Cobalt-precorrin-4 C(11)-methyltransferase cbiG 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B | Porphyrin Cobalt-precorrin-5A hydrolase cbiH 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B | Porphyrin Cobalt-factor III C(17)-methyltransferase cbiL 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Transport | Organic Biosynthesis ABC transport | Cofactor Vitamin B | ABC transport Cobalt-precorrin-2 C(20)-methyltransferase cbiM 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport ABC transport ABC transport Cobalt transport protein cbiX 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 2.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B | Porphyrin Sirohydrochlorin cobaltochelatase ccmA 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 Transport ABC transport ABC transport Cytochrome c biogenesis ATP-binding export protein ccmB 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 Transport ABC transport ABC transport Heme exporter protein ccmC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 Transport ABC transport ABC transport Heme exporter protein ccmD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 Transport ABC transport ABC transport Heme exporter protein ccoN 1.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 1.0 0.0 2.0 2.0 0.0 0.0 2.0 0.0 Transport | Organic Degration Carbohydrate | Two-component system Two-component system | Oxidative phosphorylation Cytochrome-c oxidase ccoNO 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 Transport | Organic Degration Carbohydrate | Two-component system Two-component system | Oxidative phosphorylation Cytochrome-c oxidase ccoO 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 Transport | Organic Degration Carbohydrate | Two-component system Two-component system | Oxidative phosphorylation Cytochrome-c oxidase ccoP 0.0 0.0 1.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 2.0 0.0 Transport | Organic Degration Carbohydrate | Two-component system Two-component system | Oxidative phosphorylation Cbb3-type cytochrome c oxidase ccoQ 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 1.0 0.0 1.0 0.0 Transport | Organic Degration Carbohydrate | Two-component system Two-component system | Oxidative phosphorylation Cytochrome-c oxidase ccr 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Carbon Release CO2 CO2 Crotonyl-CoA carboxylase/reductase ccrA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 ccsA 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 1.0 0.0 Organic Biosynthesis Cofactor Porphyrin Cytochrome c biogenesis protein cdd 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Nucleotide Pyrimidine Cytidine deaminase cdsA 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 0.0 0.0 Organic Transformation | Organic Biosynthesis Lipid Fatty acid Phosphatidate cytidylyltransferase celB-glu 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 Organic Degration | Organic Biosynthesis Carbohydrate Monosaccharide Phosphoglucomutase cgkA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Carbohydrate Xyloglucan | Hemicellulose Kappa-carrageenase chbC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport | Organic Degration Carbohydrate | Phosphotransferase system Phosphotransferase system | Polysaccharide PTS system N,N'-diacetylchitobiose-specific EIIC component chdC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Release | Organic Biosynthesis CO2 | Cofactor CO2 | Porphyrin Coproheme decarboxylase cheB 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.0 0.0 1.0 4.0 0.0 0.0 Transport Two-component system Two-component system Protein-glutamate methylesterase/protein-glutamine glutaminase cheD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 1.0 0.0 0.0 chiA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Carbohydrate Peptidoglycan | Chitin | Cellulose | Xyloglucan Chitinase|Lysozyme chlB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Porphyrin Light-independent protochlorophyllide reductase chlG 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Porphyrin Chlorophyll synthase chlL 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Porphyrin Light-independent protochlorophyllide reductase iron-sulfur ATP-binding protein chlN 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Porphyrin Light-independent protochlorophyllide reductase subunit N chlP 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Secondary metabolite | Cofactor Terpenoid | Porphyrin Geranylgeranyl reductase chp2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Xenobiotics Others Diacyltrehalose acyltransferase chvE 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Transport ABC transport ABC transport Multiple sugar-binding periplasmic receptor cimA 2.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 0.0 Organic Biosynthesis Amino acid Aliphatic (R)-citramalate synthase clrB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 Organic Degration Xenobiotics Selenocompound Chlorate reductase cmk 0.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 2.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 2.0 1.0 Organic Degration | Organic Biosynthesis Organophosphorus compound | Nucleotide Pyrimidine | Pyrimidine metabolism Cytidylate kinase cmpB 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport ABC transport ABC transport Bicarbonate transport system permease protein cmtG 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics Lignin 4-hydroxy-2-oxovalerate aldolase cmtH 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics Lignin Acetaldehyde dehydrogenase coaA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B Pantothenate kinase coaBC 1.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 2.0 1.0 2.0 1.0 1.0 1.0 1.0 0.0 0.0 2.0 1.0 1.0 1.0 1.0 1.0 0.0 Carbon Release | Organic Biosynthesis CO2 | Cofactor CO2 | Coenzyme Coenzyme A biosynthesis bifunctional protein CoaBC coaD 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 2.0 1.0 1.0 1.0 1.0 1.0 Organic Biosynthesis Cofactor Coenzyme Phosphopantetheine adenylyltransferase coaX 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 2.0 1.0 1.0 1.0 0.0 0.0 Organic Degration | Organic Biosynthesis Cofactor Vitamin B Type III pantothenate kinase cobA 1.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 3.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 2.0 0.0 3.0 1.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B | Porphyrin Uroporphyrinogen-III C-methyltransferase cobB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 2.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B Hydrogenobyrinate a,c-diamide synthase cobC-beta 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B Threonine-phosphate decarboxylase cobD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.0 0.0 1.0 1.0 0.0 0.0 Carbon Release | Organic Biosynthesis CO2 | Cofactor CO2 | Vitamin B | Porphyrin Threonine-phosphate decarboxylase cobF 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B | Porphyrin Precorrin-6A synthase cobH 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B Precorrin-8X methylmutase cobI 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B Precorrin-2 c(20)-methyltransferase cobJ 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B | Porphyrin Precorrin-3B C(17)-methyltransferase cobK 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B Precorrin-6A reductase cobL 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B Precorrin-6Y C(5,15)-methyltransferase cobM 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B | Porphyrin Precorrin-4 C(11)-methyltransferase cobN 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B | Porphyrin Aerobic cobaltochelatase subunit CobN cobO 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B Corrinoid adenosyltransferase cobP 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B | Porphyrin Bifunctional adenosylcobalamin biosynthesis protein CobP cobQ 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B | Porphyrin Cobyric acid synthase cobS-co 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B Aerobic cobaltochelatase subunit CobS cobS-gdp 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B Adenosylcobinamide-GDP ribazoletransferase cobT-alpha 1.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 2.0 0.0 1.0 0.0 1.0 1.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase cobT-co 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B Aerobic cobaltochelatase subunit CobT cobU-ade 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B Bifunctional adenosylcobalamin biosynthesis protein CobU cofE 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Coenzyme Coenzyme F420:L-glutamate ligase cofH 0.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Coenzyme 5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase comA 0.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 Organic Degration | Organic Biosynthesis Organic sulfur cycle | Cofactor Organic sulfur transformation | Coenzyme Phosphosulfolactate synthase comB 0.0 1.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Organic sulfur cycle | Cofactor Organic sulfur transformation | Coenzyme 2-phosphosulfolactate phosphatase comC 0.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Organic sulfur cycle | Cofactor Organic sulfur transformation | Coenzyme L-sulfolactate dehydrogenase comD 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 Organic Degration | Carbon Release | Organic Biosynthesis Organic sulfur cycle | CO2 | Cofactor CO2 | Organic sulfur transformation | Coenzyme Sulfopyruvate decarboxylase subunit alpha comE 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 Organic Degration | Carbon Release | Organic Biosynthesis Organic sulfur cycle | CO2 | Cofactor CO2 | Organic sulfur transformation | Coenzyme Sulfopyruvate decarboxylase subunit beta cooF 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Carbon Fixation | Carbon Release | Organic Degration Aromatics | CH4 | CO CO, Oxidized ferredoxin <=> CO2, Reduced ferredoxin | Aceticlastic methanogenesis | Aromatics | CO Anaerobic carbon-monoxide dehydrogenase couL 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 coxB 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 Organic Degration Carbohydrate Oxidative phosphorylation Cytochrome c oxidase coxC 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Carbohydrate Oxidative phosphorylation Cytochrome aa3 coxS 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3.0 0.0 Carbon Fixation | Carbon Release CO2 | CO CO2 | CO, Quinone <=> CO2, Hydroquinone | CO Aerboic carbon monoxide dehydrogenase crtA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Photosynthesis | Secondary metabolite Terpenoid | Photosynthetic pigment Spheroidene monooxygenase crtC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Photosynthesis | Secondary metabolite Terpenoid | Photosynthetic pigment Acyclic carotenoid 1,2-hydratase crtD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Photosynthesis | Secondary metabolite Terpenoid | Photosynthetic pigment 1-hydroxycarotenoid 3,4-desaturase crtF 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Photosynthesis | Secondary metabolite Terpenoid | Photosynthetic pigment Demethylspheroidene O-methyltransferase crtU 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Photosynthesis | Secondary metabolite Terpenoid | Photosynthetic pigment Beta-carotene desaturase ctaA 0.0 1.0 1.0 1.0 1.0 2.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 1.0 Organic Degration | Transport | Organic Biosynthesis Carbohydrate | Two-component system | Cofactor Two-component system | Oxidative phosphorylation | Porphyrin Heme A synthase ctaB 0.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 0.0 1.0 1.0 2.0 1.0 2.0 0.0 2.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 1.0 Organic Degration | Organic Biosynthesis Carbohydrate | Cofactor Oxidative phosphorylation | Porphyrin Protoheme IX farnesyltransferase ctaC 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 Organic Degration Carbohydrate Oxidative phosphorylation Cytochrome c oxidase ctaD 1.0 1.0 1.0 0.0 2.0 1.0 1.0 1.0 1.0 4.0 1.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 2.0 0.0 1.0 1.0 1.0 0.0 1.0 1.0 Organic Degration Carbohydrate Oxidative phosphorylation Cytochrome c oxidase ctaE 0.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 0.0 1.0 1.0 0.0 1.0 2.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 Organic Degration Carbohydrate Oxidative phosphorylation Cytochrome c oxidase ctaF 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Carbohydrate Oxidative phosphorylation Cytochrome c oxidase ctaG 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 Organic Degration Carbohydrate Oxidative phosphorylation Cytochrome c oxidase assembly protein cutC 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Degration Carbohydrate Monosaccharide | Pentose phosphate Glyceraldehyde dehydrogenase small chain cutM 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Fixation | Carbon Release CO2 | CO CO2 | CO, Quinone <=> CO2, Hydroquinone | CO Aerboic carbon monoxide dehydrogenase cuyA 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Organic sulfur cycle | Amino acid S side-chain | Link between inorganic and organic sulfur transformation L-cysteate sulfo-lyase cyc1 0.0 0.0 0.0 0.0 0.0 1.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 cydA 0.0 0.0 0.0 0.0 0.0 3.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 Transport | Organic Degration Carbohydrate | Two-component system Two-component system | Oxidative phosphorylation Cytochrome bd ubiquinol oxidase cydX 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 Transport | Organic Degration Carbohydrate | Two-component system Two-component system | Oxidative phosphorylation Cytochrome bd ubiquinol oxidase cymE 1.0 0.0 0.0 0.0 0.0 4.0 2.0 0.0 2.0 4.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 4.0 0.0 1.0 1.0 1.0 0.0 1.0 3.0 3.0 2.0 2.0 4.0 0.0 Organic Degration Xenobiotics Lignin acetyl-coenzyme A synthetase cynT 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Fixation | Carbon Release CO2 CO2 | CO2 <=> carbonic acid Carbonic anhydrase cyoB 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Carbohydrate Oxidative phosphorylation Cytochrome bo(3) ubiquinol oxidase cyoC 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Carbohydrate Oxidative phosphorylation Cytochrome bo(3) ubiquinol oxidase cyoD 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Carbohydrate Oxidative phosphorylation Cytochrome bo(3) ubiquinol oxidase cyoE 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Carbohydrate | Cofactor Oxidative phosphorylation | Porphyrin Protoheme IX farnesyltransferase cysA 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 2.0 2.0 1.0 0.0 0.0 Transport | Organic Degration Organic sulfur cycle | ABC transport Auxiliary | ABC transport Sulfate/thiosulfate import ATP-binding protein cysC 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 3.0 1.0 0.0 Organic Degration Inorganic sulfur transformation Assimilatory sulfate reduction Adenylyl-sulfate kinase cysD 0.0 1.0 1.0 0.0 0.0 0.0 1.0 1.0 0.0 2.0 1.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 2.0 1.0 0.0 Organic Degration | Organic Biosynthesis Xenobiotics | Amino acid | Inorganic sulfur transformation | Nucleotide Selenocompound | Purine | Se | Assimilatory sulfate reduction Sulfate adenylyltransferase cysE 1.0 0.0 0.0 0.0 1.0 1.0 0.0 2.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 3.0 1.0 1.0 2.0 1.0 0.0 Organic Degration | Organic Biosynthesis Organic sulfur cycle | Amino acid L-Amino acid | Alcohol | Link between inorganic and organic sulfur transformation | S side-chain Serine O-acetyltransferase cysG 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 2.0 1.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B | Porphyrin Siroheme synthase cysH 0.0 1.0 1.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 Organic Degration Inorganic sulfur transformation Assimilatory sulfate reduction Phosphoadenosine phosphosulfate reductase cysI 0.0 0.0 0.0 0.0 0.0 2.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Inorganic sulfur transformation Assimilatory sulfate reduction Sulfite reductase (NADPH) hemoprotein beta-component cysJ 0.0 0.0 0.0 0.0 0.0 4.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 2.0 0.0 0.0 0.0 Organic Degration Inorganic sulfur transformation Assimilatory sulfate reduction Sulfite reductase (NADPH) flavoprotein alpha-component cysK 2.0 1.0 1.0 3.0 1.0 4.0 2.0 1.0 3.0 3.0 3.0 3.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 1.0 1.0 3.0 0.0 2.0 1.0 2.0 2.0 4.0 1.0 1.0 1.0 Organic Degration | Organic Biosynthesis Organic sulfur cycle | Amino acid L-Amino acid | S side-chain | Link between inorganic and organic sulfur transformation Cysteine synthase cysK2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Amino acid L-Amino acid | S side-chain S-sulfocysteine synthase cysM 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 2.0 1.0 0.0 0.0 1.0 0.0 Organic Degration | Organic Biosynthesis Organic sulfur cycle | Amino acid L-Amino acid | S side-chain | Link between inorganic and organic sulfur transformation Cysteine synthase cysN 0.0 0.0 1.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 Organic Degration | Organic Biosynthesis Xenobiotics | Inorganic sulfur transformation | Nucleotide Selenocompound | Purine | Assimilatory sulfate reduction Sulfate adenylyltransferase subunit 1 cysN_cysC 0.0 0.0 1.0 0.0 0.0 1.0 1.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 2.0 1.0 1.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 cysQ 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 Organic Degration Inorganic sulfur transformation Assimilatory sulfate reduction 3'(2'), 5'-bisphosphate nucleotidase cysU 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 Transport | Organic Degration Organic sulfur cycle | ABC transport Auxiliary | ABC transport Sulfate transport system permease protein cysW 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 0.0 0.0 Transport | Organic Degration Organic sulfur cycle | ABC transport Auxiliary | ABC transport Sulfate transport system permease protein cysZ 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Degration Organic sulfur cycle Auxiliary Sulfate transporter CysZ dacB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 4.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation Glycan Peptidoglycan Carboxypeptidase|D-alanyl-D-alanine carboxypeptidase dacC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation Glycan Peptidoglycan D-alanyl-D-alanine carboxypeptidase dad 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Degration Aromatics Aromatics 2,4'-dihydroxyacetophenone dioxygenase dadA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 1.0 0.0 dagK 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Transformation | Organic Biosynthesis Lipid Fatty acid Diacylglycerol kinase dapA 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Amino acid L-Amino acid | Cationic 4-hydroxy-tetrahydrodipicolinate synthase dapB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Amino acid L-Amino acid | Cationic 4-hydroxy-tetrahydrodipicolinate reductase dapE 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 2.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 Organic Biosynthesis Amino acid L-Amino acid | Cationic Succinyl-diaminopimelate desuccinylase dapL 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 Organic Biosynthesis Amino acid Cationic LL-diaminopimelate aminotransferase dat 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 2.0 0.0 Organic Degration | Organic Transformation | Organic Biosynthesis Amino acid Aliphatic | Cationic | D-Amino acid D-alanine aminotransferase|Diaminobutyrate--2-oxoglutarate aminotransferase dat-K00836 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 dauA-K19746 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Transformation | Organic Degration Amino acid D-Amino acid FAD-dependent catabolic D-arginine dehydrogenase davT 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Amino acid L-Amino acid | Cationic 5-aminovalerate aminotransferase dcd 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 1.0 1.0 0.0 2.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 Organic Degration | Organic Biosynthesis Organophosphorus compound | Nucleotide Pyrimidine | Pyrimidine metabolism dCTP deaminase dck 0.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Nucleotide Purine Deoxyadenosine/deoxycytidine kinase dcm 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Nucleotide Pyrimidine DNA-cytosine methyltransferase dcsE 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Amino acid L-Amino acid | Alcohol Serine O-succinyltransferase dcsG 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Release CO2 CO2 Cycloserine biosynthesis protein ddl 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 Organic Transformation | Organic Biosynthesis Glycan | Amino acid Peptidoglycan | D-Amino acid D-alanine--D-alanine ligase deoB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 Organic Degration | Organic Biosynthesis Organophosphorus compound | Nucleotide | Carbohydrate Monosaccharide | Purine | Pentose phosphate pathway | Pentose phosphate Phosphopentomutase deoC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Carbohydrate Monosaccharide | Pentose phosphate Deoxyribose-phosphate aldolase deoD 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Cofactor | Nucleotide Purine | Pyrimidine | Vitamin B Purine nucleoside phosphorylase desA1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation Lipid Fatty acid Acyl-[acyl-carrier-protein] desaturase desA2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation Lipid Fatty acid Acyl-[acyl-carrier-protein] desaturase desV 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 devB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Carbohydrate Monosaccharide | Pentose phosphate 6-phosphogluconolactonase dgkA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 2.0 1.0 0.0 0.0 1.0 0.0 Organic Degration | Organic Transformation | Organic Biosynthesis Glycan | Lipid | Carbohydrate Peptidoglycan | Fatty acid Diacylglycerol kinase dgoA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 Organic Degration Carbohydrate Monosaccharide 2-dehydro-3-deoxy-6-phosphogalactonate aldolase dgoD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Carbohydrate Monosaccharide D-galactonate dehydratase dgt 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Nucleotide Purine Deoxyguanosinetriphosphate triphosphohydrolase dhaK 0.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 2.0 0.0 1.0 0.0 0.0 0.0 Organic Degration Lipid Fatty acid Dihydroxyacetone kinase|PEP-dependent dihydroxyacetone kinase|PTS-dependent dihydroxyacetone kinase dhaL 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Lipid Fatty acid PEP-dependent dihydroxyacetone kinase|PTS-dependent dihydroxyacetone kinase|Phosphoenolpyruvate--glycerone phosphotransferase dhbA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration Aromatics Aromatics 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase dhlDH 2.0 1.0 1.0 0.0 1.0 3.0 2.0 2.0 2.0 2.0 1.0 2.0 3.0 2.0 2.0 2.0 1.0 2.0 2.0 1.0 1.0 1.0 2.0 3.0 0.0 1.0 1.0 2.0 3.0 3.0 2.0 2.0 1.0 Organic Transformation | Organic Degration Xenobiotics Lignin dihydrolipoamide dehydrogenase dht 0.0 1.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Amino acid | Nucleotide | Cofactor Vitamin B | Pyrimidine | beta-amino acid D-hydantoinase/dihydropyrimidinase dmdB 0.0 0.0 0.0 0.0 0.0 3.0 0.0 0.0 0.0 1.0 0.0 3.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 2.0 0.0 Organic Degration | Organic Biosynthesis Xenobiotics | Organic sulfur cycle | DMSP catabolic pathway | Cofactor Vitamin B | Organic sulfur transformation | DMSP demethylation | DMS synthesis | Vitamin E | Lignin 3-(methylthio)propionyl---CoA ligase dmdC 0.0 0.0 1.0 0.0 0.0 2.0 0.0 0.0 0.0 2.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 3.0 1.0 3.0 0.0 1.0 0.0 Organic Degration Organic sulfur cycle | DMSP catabolic pathway Organic sulfur transformation | DMS synthesis | DMSP demethylation 3-(methylthio)propanoyl-CoA dehydrogenase dmdD 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 2.0 1.0 0.0 1.0 0.0 Carbon Release | Organic Degration Organic sulfur cycle | CO2 | DMSP catabolic pathway CO2 | Organic sulfur transformation | DMS synthesis | DMSP demethylation (methylthio)acryloyl-CoA hydratase dml 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Cofactor Lignin | Vitamin B | Vitamin E 2,3-dimethylmalate lyase dmpB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Aromatics Aromatics | Lignin | Styrene Metapyrocatechase|Catechol 2,3-dioxygenase dmpC 0.0 2.0 0.0 1.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 1.0 1.0 0.0 2.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 Organic Degration Xenobiotics | Aromatics Aromatics | Lignin 2-hydroxymuconic semialdehyde dehydrogenase dmpD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Aromatics Aromatics | Styrene 2-hydroxymuconate semialdehyde hydrolase dmpE 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics Lignin 2-oxopent-4-enoate hydratase(2-hydroxypent-2,4-dienoate hydratase) dmpF 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics Lignin Acetaldehyde dehydrogenase dmpG 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics Lignin 4-hydroxy-2-oxovalerate aldolase dmpH 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 Carbon Release | Organic Degration Xenobiotics | CO2 | Aromatics Organic pollutant | CO2 | Lignin | Aromatics 4-oxalocrotonate decarboxylase dmpI 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics Lignin 2-hydroxymuconate tautomerase dmpL 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Aromatics Organic pollutant | Aromatics | Lignin Phenol 2-monooxygenase, oxygenase component dmpM 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Aromatics | Secondary metabolite | Antibiotic Organic pollutant | Aromatics | Antibiotic | Secondary metabolite | Lignin Phenol 2-monooxygenase, stimulatory component dmpN 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Aromatics Organic pollutant | Aromatics | Lignin Phenol 2-monooxygenase, oxygenase component dmpO 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Aromatics Organic pollutant | Aromatics | Lignin Phenol 2-monooxygenase, oxygenase component dmpP 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Aromatics Organic pollutant | Aromatics | Lignin Phenol 2-monooxygenase, reductase component dmsA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Organic sulfur cycle Organic sulfur transformation Anaerobic dimethyl sulfoxide reductase subunit A dmsB 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Organic sulfur cycle Organic sulfur transformation Anaerobic dimethyl sulfoxide reductase subunit B doeB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 doeD 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 dppA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Transport ABC transport ABC transport ABC transporter substrate-binding protein dppB 1.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Transport ABC transport ABC transport Dipeptide transport system permease protein|Di/tripeptide transport system permease protein dppC 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 Transport ABC transport ABC transport Dipeptide transport system permease protein|Di/tripeptide transport system permease protein dppF 0.0 0.0 0.0 0.0 0.0 3.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 Transport ABC transport ABC transport Dipeptide transport ATP-binding protein|Dipeptide transport system permease protein|Di/tripeptide transport system permease protein dsdA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 dsrA 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Aromatics | Inorganic sulfur transformation Aromatics | Dissimilatory sulfur reduction and oxidation Sulfite reductase dsrC 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Inorganic sulfur transformation Dissimilatory sulfur reduction and oxidation Dissimilatory sulfite reductase related protein dsrK 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Inorganic sulfur transformation Dissimilatory sulfur reduction and oxidation Protein DsrK dsrL 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Inorganic sulfur transformation Dissimilatory sulfur reduction and oxidation Protein DsrL dsrM 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Inorganic sulfur transformation Dissimilatory sulfur reduction and oxidation Protein DsrM dthadh 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 dut 1.0 1.0 1.0 2.0 1.0 1.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 Organic Degration | Organic Biosynthesis Organophosphorus compound | Nucleotide Pyrimidine | Pyrimidine metabolism dUTP pyrophosphatase dxr 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Secondary metabolite Terpenoid 1-deoxy-D-xylulose-5-phosphate reductoisomerase dxs 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Release | Organic Biosynthesis CO2 | Secondary metabolite | Cofactor Terpenoid | CO2 | Vitamin B 1-deoxy-D-xylulose-5-phosphate synthase eba736 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics Lignin Putative acyl-CoA dehydrogenase eba738 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics Lignin Putative alcohol dehydrogenase ech 0.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 6.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics Lignin Enoyl-CoA hydratase/aldolase ecm 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 ectD 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Release | Organic Biosynthesis Xenobiotics | CO2 Others | CO2 Ectoine dioxygenase eda 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 2.0 0.0 0.0 0.0 Organic Degration Carbohydrate Galacturonic acid | Pentose phosphate 2-dehydro-3-deoxy-phosphogluconate aldolase|KHG/KDPG aldolase edd 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration Carbohydrate Monosaccharide | Pentose phosphate Phosphogluconate dehydratase efeB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics Lignin Deferrochelatase/peroxidase efeN 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics Lignin Probable deferrochelatase/peroxidase ehbE 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Release CH4 Central methanogenic pathway Energy-converting hydrogenase B eltD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 embA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Glycan Galactoarabinan Arabinosyltransferase A embB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Glycan Galactoarabinan Arabinosyltransferase B embC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Biosynthesis Glycan Glycolipid | Galactoarabinan | Lipoarabinomannan Arabinosyltransferase C eno 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Carbon Fixation | Organic Degration Carbohydrate | CH4 | Methane-aerobic Aerobic oxidation | serine cycle | Glycolysis Enolase entF 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 epd 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B D-erythrose-4-phosphate dehydrogenase epi 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Carbon Fixation | Organic Degration Carbohydrate | CO2 Fermentation | 3-Hydroxypropionate Bicycle | 3-Hydroxypropionate/4-Hydroxybutyrate Cycle Ethylmalonyl-CoA/methylmalonyl-CoA epimerase eptB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Biosynthesis Glycan Lipopolysaccharide Kdo(2)-lipid A phosphoethanolamine 7''-transferase eryCI 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 eryF 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport | Organic Transformation | Organic Biosynthesis Lipid | ABC transport Polyketide | ABC transport 6-deoxyerythronolide B hydroxylase ethA 0.0 0.0 0.0 0.0 0.0 3.0 2.0 0.0 0.0 2.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Degration Aromatics Aromatics FAD-containing monooxygenase|Monooxygenase eutE 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Carbohydrate Pyruvate Aldehyde dehydrogenase exaA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 2.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Xenobiotics | Carbohydrate Organic pollutant | Fermentation | Pyruvate | Glycolysis Alcohol dehydrogenase(cytochrome c) fabA 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Lipid Fatty acid 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase fabB 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 Carbon Release | Organic Biosynthesis CO2 | Lipid | Cofactor CO2 | Vitamin B | Fatty acid 3-oxoacyl-[acyl-carrier-protein] synthase fabD 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 Organic Biosynthesis Lipid Fatty acid Malonyl CoA-acyl carrier protein transacylase fabF 2.0 2.0 1.0 3.0 3.0 2.0 1.0 3.0 1.0 2.0 1.0 1.0 3.0 1.0 1.0 1.0 1.0 3.0 1.0 0.0 3.0 1.0 1.0 2.0 1.0 2.0 0.0 1.0 0.0 1.0 3.0 2.0 1.0 Carbon Release | Organic Biosynthesis CO2 | Lipid | Cofactor CO2 | Vitamin B | Fatty acid 3-oxoacyl-[acyl-carrier-protein] synthase fabG 2.0 2.0 2.0 3.0 4.0 10.0 4.0 6.0 2.0 12.0 2.0 2.0 3.0 2.0 2.0 3.0 2.0 1.0 2.0 1.0 3.0 2.0 1.0 3.0 2.0 2.0 1.0 4.0 5.0 9.0 3.0 13.0 1.0 Organic Biosynthesis Lipid | Cofactor Vitamin B | Fatty acid 3-oxoacyl-[acyl-carrier-protein] reductase fabH 1.0 3.0 3.0 2.0 3.0 0.0 3.0 0.0 3.0 0.0 2.0 1.0 1.0 2.0 1.0 1.0 3.0 1.0 1.0 0.0 1.0 0.0 3.0 0.0 1.0 1.0 1.0 1.0 0.0 1.0 2.0 1.0 0.0 Carbon Release | Organic Biosynthesis CO2 | Lipid CO2 | Fatty acid 3-oxoacyl-[acyl-carrier-protein] synthase fabI 0.0 1.0 1.0 1.0 1.0 2.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 2.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 0.0 2.0 0.0 3.0 1.0 1.0 1.0 Organic Biosynthesis Lipid | Cofactor Vitamin B | Fatty acid Enoyl-[acyl-carrier-protein] reductase fabK 0.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 Organic Biosynthesis Lipid Fatty acid Enoyl-[acyl carrier protein] reductase fabL 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Biosynthesis Lipid Fatty acid Enoyl-[acyl-carrier-protein] reductase fabV 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Lipid Fatty acid Enoyl-[acyl-carrier-protein] reductase fabZ 1.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 0.0 0.0 1.0 1.0 0.0 4.0 0.0 0.0 1.0 1.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Organic Biosynthesis Lipid | Cofactor Vitamin B | Fatty acid 3-hydroxyacyl-[acyl-carrier-protein] dehydratase fadA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 1.0 0.0 Organic Degration Aromatics | Lipid Aromatics | Fatty acid Acetyl-CoA acetyltransferase fadB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Aromatics | Xenobiotics | CO2 | Lipid | Amino acid L-Amino acid | Aromatics | 3-Hydroxypropionate/4-Hydroxybutyrate Cycle | Fatty acid | Plastics | Dicarboxylate/4-hydroxybutyrate cycle 3-hydroxybutyryl-CoA dehydrogenase fadCL 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics Lignin Long-chain-fatty-acid-CoA ligase fadD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Lipid Fatty acid Long-chain-fatty-acid--CoA ligase fadE 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Lipid Fatty acid Acyl-coenzyme A dehydrogenase fadN 0.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 Organic Degration | Carbon Fixation | Organic Biosynthesis CO2 | Lipid | Aromatics Aromatics | 3-Hydroxypropionate/4-Hydroxybutyrate Cycle | Fatty acid 3-hydroxyacyl-CoA dehydrogenase fae 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Fixation | Organic Degration CH4 | Methane-aerobic Aerobic oxidation | Oxidation of formaldehyde 5,6,7,8-tetrahydromethanopterin hydro-lyase fae-hps 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Carbohydrate | CH4 | Methane-aerobic Monosaccharide | RuMP pathway | Aerobic oxidation | Pentose phosphate Bifunctional enzyme Fae/Hps fah 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics Lignin Fumarylacetoacetase fbaA 1.0 0.0 1.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Photosynthesis | Methane-aerobic | CH4 | Carbohydrate | CO2 Aerobic oxidation | Pentose phosphate | Calvin cycle | Calvin-Benson-Bassham Cycle | Glycolysis | RuMP pathway Fructose-bisphosphate aldolase fbaB 0.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Photosynthesis | Methane-aerobic | CH4 | Carbohydrate | CO2 Aerobic oxidation | Pentose phosphate | Calvin cycle | Calvin-Benson-Bassham Cycle | Glycolysis | RuMP pathway Fructose-bisphosphate aldolase fbcH 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 Transport | Organic Degration Carbohydrate | Two-component system Two-component system | Oxidative phosphorylation Cytochrome b|Cytochrome c1 fbiC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 fbiD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Coenzyme Phosphoenolpyruvate guanylyltransferase|3-phospho-D-glycerate guanylyltransferase fbp 0.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 2.0 1.0 2.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Glycan | Photosynthesis | Methane-aerobic | CH4 | Carbohydrate | CO2 | Lipid Aerobic oxidation | Calvin cycle | Pentose phosphate | Monosaccharide | Calvin-Benson-Bassham Cycle | Fatty acid | Galactoarabinan | RuMP pathway Fructose-1,6-bisphosphatase I fccA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Inorganic sulfur transformation Sulfur oxidation Cytochrome subunit of sulfide dehydrogenase fccB 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 2.0 0.0 Organic Degration Inorganic sulfur transformation Sulfur oxidation Sulfide dehydrogenase [flavocytochrome c] flavoprotein chain fdhA 3.0 0.0 0.0 1.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 Carbon Fixation | Carbon Release | Organic Degration Xenobiotics | CO2 | CH4 | Methane-aerobic Organic pollutant | Aerobic oxidation | Reductive acetyl-CoA pathway | Oxidation of formate | CO2 Formate dehydrogenase|Glutathione-independent formaldehyde dehydrogenase fdhA-K00148 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Fixation | Organic Degration CH4 | Methane-aerobic Aerobic oxidation | Oxidation of formaldehyde Glutathione-independent formaldehyde dehydrogenase fdm 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Fixation | Organic Degration Xenobiotics | CH4 | Methane-aerobic Organic pollutant | Aerobic oxidation | Oxidation of formaldehyde Formaldehyde dismutase fdnG 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Carbon Release CO2 CO2 Formate dehydrogenase-N fdoG 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 Carbon Fixation | Carbon Release | Organic Degration CO2 | CH4 | Methane-aerobic CO2 | Aerobic oxidation | Oxidation of formate Formate dehydrogenase fdoH 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Carbon Fixation | Carbon Release | Organic Degration CO2 | CH4 | Methane-aerobic CO2 | Aerobic oxidation | Oxidation of formate Formate dehydrogenase fdoI 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Carbon Fixation | Carbon Release | Organic Degration CO2 | CH4 | Methane-aerobic CO2 | Aerobic oxidation | Oxidation of formate Formate dehydrogenase fdsD 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Carbon Fixation | Carbon Release | Organic Degration CO2 | CH4 | Methane-aerobic CO2 | Aerobic oxidation | Oxidation of formate NAD-dependent formate dehydrogenase fdtB 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 feaB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics Styrene Phenylacetaldehyde dehydrogenase fghA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 2.0 0.0 0.0 0.0 Carbon Fixation | Organic Degration CH4 | Methane-aerobic Aerobic oxidation | Oxidation of formaldehyde S-formylglutathione hydrolase fhs 1.0 0.0 1.0 1.0 3.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 0.0 0.0 1.0 2.0 1.0 0.0 0.0 1.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 Carbon Fixation | Organic Transformation | Organic Degration Xenobiotics | CO2 | Cofactor Vitamin B | Lignin | Reductive acetyl-CoA pathway Formate--tetrahydrofolate ligase fkbP 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Biosynthesis Lipid Polyketide FK506-binding protein fmt 1.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 1.0 0.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 0.0 0.0 1.0 2.0 1.0 1.0 0.0 0.0 1.0 3.0 1.0 1.0 1.0 1.0 1.0 0.0 Organic Degration Cofactor Vitamin B Methionyl-tRNA formyltransferase folA 1.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 1.0 2.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 2.0 0.0 Carbon Fixation | Organic Degration CH4 | Methane-aerobic | Cofactor Aerobic oxidation | Vitamin B | serine cycle Dihydrofolate reductase folB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B Dihydroneopterin aldolase folD 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 2.0 1.0 3.0 1.0 3.0 1.0 1.0 1.0 Carbon Fixation | Organic Degration CO2 | Cofactor Vitamin B | Reductive acetyl-CoA pathway Methylenetetrahydrofolate dehydrogenase folE 2.0 2.0 1.0 2.0 2.0 1.0 1.0 0.0 2.0 1.0 1.0 1.0 1.0 1.0 2.0 0.0 2.0 1.0 1.0 2.0 1.0 1.0 1.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 1.0 1.0 1.0 Organic Degration Cofactor Vitamin B GTP cyclohydrolase folE2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 2.0 0.0 1.0 0.0 0.0 0.0 Organic Degration Cofactor Vitamin B GTP cyclohydrolase folK 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folP 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B Dihydropteroate synthase|Folylpolyglutamate synthase fpoA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 Carbon Fixation | Carbon Release | Organic Degration Methane-anaerobic | CH4 Anaerobic oxidation of methane | Central methanogenic pathway F420H2 dehydrogenase fpoB 1.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 0.0 1.0 0.0 1.0 1.0 0.0 0.0 0.0 1.0 2.0 0.0 0.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 1.0 0.0 Carbon Fixation | Carbon Release | Organic Degration Methane-anaerobic | CH4 Anaerobic oxidation of methane | Central methanogenic pathway F420H2 dehydrogenase fpoD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Carbon Fixation | Carbon Release | Organic Degration Methane-anaerobic | CH4 Anaerobic oxidation of methane | Central methanogenic pathway F420H2 dehydrogenase fpoH 1.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 2.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Fixation | Carbon Release | Organic Degration Methane-anaerobic | CH4 Anaerobic oxidation of methane | Central methanogenic pathway F420H2 dehydrogenase fpoK 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 0.0 0.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 2.0 1.0 0.0 Carbon Fixation | Carbon Release | Organic Degration Methane-anaerobic | CH4 Anaerobic oxidation of methane | Central methanogenic pathway F420H2 dehydrogenase fpoL 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Carbon Fixation | Carbon Release | Organic Degration Methane-anaerobic | CH4 Anaerobic oxidation of methane | Central methanogenic pathway F420H2 dehydrogenase fpoM 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Fixation | Carbon Release | Organic Degration Methane-anaerobic | CH4 Anaerobic oxidation of methane | Central methanogenic pathway F420H2 dehydrogenase fpoN 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 Carbon Fixation | Carbon Release | Organic Degration Methane-anaerobic | CH4 Anaerobic oxidation of methane | Central methanogenic pathway F420H2 dehydrogenase fpr 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 2.0 1.0 1.0 0.0 3.0 0.0 Transport Phosphotransferase system Phosphotransferase system Ferredoxin--NADP reductase|Flavodoxin/ferredoxin--NADP reductase frcA-trans 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 Transport ABC transport ABC transport Fructose import ATP-binding protein frcB-trans 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Transport ABC transport ABC transport Fructose import binding protein frcC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Transport ABC transport ABC transport Fructose import permease protein frdA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 Organic Degration | Carbon Fixation | Transport | Organic Biosynthesis Carbohydrate | CO2 | Two-component system Two-component system | Fermentation | 3-Hydroxypropionate Bicycle | Dicarboxylate/4-hydroxybutyrate cycle | Oxidative phosphorylation | Reductive tricarboxylic acid cycle | Pyruvate FSuccinate dehydrogenase|Fumarate reductase flavoprotein frdB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 Organic Degration | Carbon Fixation | Transport | Organic Biosynthesis Carbohydrate | CO2 | Two-component system Two-component system | 3-Hydroxypropionate Bicycle | Dicarboxylate/4-hydroxybutyrate cycle | Oxidative phosphorylation | Reductive tricarboxylic acid cycle | Pyruvate Fumarate reductase iron-sulfur|Succinate dehydrogenase iron-sulfur frhG 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Carbon Fixation | Carbon Release | Organic Degration Methane-anaerobic | CH4 Anaerobic oxidation of methane | Central methanogenic pathway Coenzyme F420 hydrogenase frmA 0.0 0.0 0.0 0.0 1.0 2.0 0.0 0.0 0.0 2.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Aromatics | Methane-aerobic | Cofactor | CH4 | Xenobiotics | Carbohydrate | Lipid Aromatics | Aerobic oxidation | Organic pollutant | Vitamin A | Glycolysis | Fatty acid | Oxidation of formaldehyde | Pyruvate S-(hydroxymethyl)glutathione dehydrogenase frmB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Carbon Fixation | Organic Degration CH4 | Methane-aerobic Aerobic oxidation | Oxidation of formaldehyde S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase ftr 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Fixation | Carbon Release | Organic Degration Methane-anaerobic | CH4 Anaerobic oxidation of methane | Hydrogenotrophic methanogenesis Formylmethanofuran--tetrahydromethanopterin N-formyltransferase ftsE 0.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 2.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 1.0 0.0 Transport ABC transport ABC transport Cell division ATP-binding protein ftsI 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 Organic Transformation Glycan Peptidoglycan Peptidoglycan D,D-transpeptidase ftsX 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Transport ABC transport ABC transport Cell division protein fucA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Carbohydrate Fucose L-fuculose phosphate aldolase fumA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Carbohydrate | CO2 Citrate cycle | Pyruvate | Fermentation | Dicarboxylate/4-hydroxybutyrate cycle Fumarate hydratase fumB 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Carbohydrate | CO2 Citrate cycle | Pyruvate | Fermentation | Dicarboxylate/4-hydroxybutyrate cycle Fumarate hydratase fumC 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 0.0 1.0 1.0 1.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 0.0 1.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Carbohydrate | CO2 Pyruvate | Citrate cycle | Dicarboxylate/4-hydroxybutyrate cycle | 3-Hydroxypropionate Bicycle Fumarate hydratase gabD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Amino acid | Cofactor L-Amino acid | Vitamin B | Vitamin E Succinate-semialdehyde dehydrogenase gabT 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Amino acid Aliphatic | beta-amino acid | Cationic 4-aminobutyrate aminotransferase gadA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Carbon Release | Organic Biosynthesis CO2 | Amino acid Aliphatic | CO2 | Anionic | beta-amino acid Glutamate decarboxylase galD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration | Organic Transformation | Organic Biosynthesis Xenobiotics | Carbohydrate | Aromatics Monosaccharide | Aromatics | Lignin 4-oxalomesaconate tautomerase galR 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics Lignin HTH-type transcriptional regulator GalR OS=Pseudomonas putida galU 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Carbohydrate Monosaccharide | Glycan UTP--glucose-1-phosphate uridylyltransferase gapA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Carbohydrate | CO2 | Photosynthesis Calvin cycle | Calvin-Benson-Bassham Cycle | Glycolysis Glyceraldehyde-3-phosphate dehydrogenase gapA2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 garD 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 gatD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation Glycan Peptidoglycan Lipid II isoglutaminyl synthase gcd 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Organophosphorus compound | Carbohydrate Monosaccharide | Pentose phosphate pathway | Pentose phosphate Glucose dehydrogenase gcdB 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Carbon Release | Organic Biosynthesis Carbohydrate | CO2 | Aromatics CO2 | Aromatics | Pyruvate Glutaconyl-CoA decarboxylase gcdC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Aromatics Aromatics Glutaconyl-CoA decarboxylase|Methylmalonyl-CoA decarboxylase gci 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 gck 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Methane-aerobic | CH4 | Carbohydrate | Lipid | Amino acid Aerobic oxidation | Pentose phosphate | Monosaccharide | serine cycle | Fatty acid | Aliphatic Glycerate 2-kinase gcl 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Release CO2 CO2 Glyoxylate carboligase gcvH 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 1.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Organic Degration | Organic Biosynthesis Amino acid Aliphatic Glycine cleavage system gcvP 0.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Organic Degration | Carbon Release | Organic Biosynthesis CO2 | Amino acid Aliphatic | CO2 Glycine dehydrogenase gcvPA 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Carbon Release | Organic Biosynthesis CO2 | Amino acid Aliphatic | CO2 Glycine dehydrogenase gcvPB 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Carbon Release | Organic Biosynthesis CO2 | Amino acid Aliphatic | CO2 Glycine dehydrogenase gcvT 0.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 1.0 3.0 1.0 2.0 1.0 1.0 1.0 Organic Degration | Organic Biosynthesis Amino acid | Cofactor Aliphatic | Vitamin B Aminomethyltransferase gdh 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Transformation | Organic Biosynthesis Xenobiotics | Organophosphorus compound | Carbohydrate Monosaccharide | Pentose phosphate pathway | Pentose phosphate | Lignin Glucose 1-dehydrogenase gdhA 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 2.0 1.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Organic Degration | Organic Biosynthesis Carbohydrate | Amino acid Anionic | Pentose phosphate | Monosaccharide | Cationic | Aliphatic Glutamate dehydrogenase gdh_K00260 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Nitrogen cycle Organic degradation and synthesis Glutamate dehydrogenase gdh_K00261 0.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 2.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 1.0 0.0 0.0 Organic Degration Nitrogen cycle Organic degradation and synthesis Glutamate dehydrogenase (NAD(P)+) gdh_K00262 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 1.0 1.0 Organic Degration Organic sulfur cycle | Nitrogen cycle Organic sulfur transformation | Organic degradation and synthesis Glutamate dehydrogenase (NADP+) gdh_K15371 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Nitrogen cycle Organic degradation and synthesis Glutamate dehydrogenase gfa 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 1.0 3.0 0.0 1.0 0.0 Carbon Fixation | Organic Degration CH4 | Methane-aerobic Aerobic oxidation | Oxidation of formaldehyde S-(hydroxymethyl)glutathione synthase ggt 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 gip 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 glcB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 0.0 Organic Degration | Organic Biosynthesis Carbohydrate Glyoxylate cycle | Pyruvate | Glycolysis Malate synthase glf 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Carbohydrate Monosaccharide | Glycan UDP-galactopyranose mutase glfT1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 glfT2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 glgA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration Carbohydrate Starch Starch synthase glgB 0.0 2.0 2.0 2.0 1.0 2.0 1.0 4.0 1.0 1.0 1.0 0.0 0.0 1.0 0.0 2.0 2.0 5.0 0.0 2.0 4.0 1.0 2.0 4.0 1.0 4.0 4.0 0.0 0.0 1.0 2.0 0.0 0.0 Organic Degration Carbohydrate Starch 1,4-alpha-glucan branching enzyme glgC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 glgE 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Carbohydrate Starch Starch synthase (maltosyl-transferring) glk 0.0 1.0 2.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 Organic Degration | Transport | Organic Biosynthesis Carbohydrate | Secondary metabolite | Antibiotic | Transport system Antibiotic | Monosaccharide | Glycolysis | Transport system | Secondary metabolite | Polysaccharide Glucokinase glmM 3.0 0.0 0.0 0.0 0.0 3.0 1.0 1.0 0.0 1.0 0.0 2.0 2.0 0.0 1.0 1.0 0.0 0.0 1.0 2.0 2.0 2.0 0.0 0.0 1.0 0.0 0.0 3.0 2.0 1.0 2.0 2.0 1.0 glmS 3.0 1.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 glmU 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 2.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 glnA 1.0 1.0 1.0 1.0 1.0 2.0 0.0 1.0 1.0 5.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 2.0 2.0 3.0 1.0 1.0 0.0 0.0 2.0 2.0 2.0 4.0 1.0 1.0 1.0 Organic Degration | Transport | Organic Biosynthesis Nitrogen cycle | Amino acid | Aromatics | Two-component system Two-component system | Aromatics | Organic degradation and synthesis | Cationic | Aliphatic Glutamine synthetase glnQ 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 3.0 0.0 1.0 0.0 Transport ABC transport ABC transport Glutamine transport ATP-binding protein glpD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 Organic Transformation | Organic Biosynthesis Lipid Fatty acid Aerobic glycerol-3-phosphate dehydrogenase glpE 0.0 2.0 1.0 1.0 3.0 5.0 0.0 0.0 0.0 5.0 1.0 1.0 1.0 2.0 1.0 0.0 3.0 1.0 3.0 2.0 0.0 0.0 1.0 1.0 0.0 0.0 1.0 3.0 0.0 0.0 2.0 0.0 0.0 Organic Degration Inorganic sulfur transformation Sulfur oxidation Thiosulfate sulfurtransferase glpK 0.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 1.0 0.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 2.0 0.0 1.0 0.0 Organic Biosynthesis Lipid Fatty acid Glycerol kinase glpQ 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Organophosphorus compound | Lipid Organic phosphoester hydrolysis | Fatty acid Glycerophosphodiester phosphodiesterase glpQ-trans 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Transport ABC transport ABC transport Glycerol transport system permease protein glpT 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport | Organic Biosynthesis Organophosphorus compound | ABC transport Transmembrane transport | ABC transport Glycerol-3-phosphate transporter glpX 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Photosynthesis | Methane-aerobic | CH4 | Carbohydrate | CO2 Aerobic oxidation | Pentose phosphate | Calvin cycle | Calvin-Benson-Bassham Cycle | Glycolysis | RuMP pathway Fructose-1,6-bisphosphatase II glpX-SEBP 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Photosynthesis | CH4 | Methane-aerobic RuMP pathway | Aerobic oxidation | Calvin cycle Fructose-1,6-bisphosphatase II/sedoheptulose-1,7-bisphosphatase glsA 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 1.0 1.0 0.0 1.0 1.0 0.0 0.0 0.0 Organic Degration | Transport | Organic Transformation | Organic Biosynthesis Nitrogen cycle | Amino acid | Two-component system L-Amino acid | Two-component system | Organic degradation and synthesis | D-Amino acid Glutaminase gltA 1.0 1.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 0.0 1.0 1.0 2.0 1.0 1.0 2.0 1.0 1.0 1.0 3.0 1.0 1.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Carbohydrate | CO2 | Amino acid Citrate cycle | Anionic | Reductive acetyl-CoA pathway | Glyoxylate cycle Citrate synthase gltB 1.0 1.0 3.0 1.0 2.0 4.0 0.0 2.0 0.0 2.0 3.0 1.0 0.0 3.0 0.0 1.0 0.0 2.0 0.0 1.0 1.0 1.0 1.0 2.0 0.0 0.0 1.0 3.0 3.0 1.0 2.0 2.0 0.0 Organic Degration | Organic Biosynthesis Amino acid Aliphatic | Anionic Glutamate synthase|Ferredoxin-dependent glutamate synthase gltD 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Amino acid Aliphatic | Anionic Glutamate synthase gltI 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Transport Two-component system | ABC transport Two-component system | ABC transport Glutamate/aspartate import solute-binding protein gltJ 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Transport Two-component system | ABC transport Two-component system | ABC transport Glutamate/aspartate import permease protein gltK 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Transport Two-component system | ABC transport Two-component system | ABC transport Glutamate/aspartate import permease protein gltL 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Transport Two-component system | ABC transport Two-component system | ABC transport Glutamate/aspartate import ATP-binding protein gltS 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 gltX 1.0 2.0 2.0 2.0 2.0 5.0 2.0 3.0 2.0 3.0 2.0 3.0 2.0 2.0 2.0 3.0 2.0 2.0 2.0 1.0 4.0 3.0 2.0 1.0 1.0 1.0 3.0 3.0 3.0 3.0 2.0 3.0 1.0 Organic Biosynthesis Cofactor Vitamin B | Porphyrin Glutamate--tRNA ligase gluA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Transport ABC transport ABC transport Glutamate transport ATP-binding protein gluB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport ABC transport ABC transport Glutamate-binding protein gluC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport ABC transport ABC transport Glutamate transport system permease protein gluD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport ABC transport ABC transport Glutamate transport system permease protein glyA 1.0 1.0 2.0 1.0 1.0 2.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Amino acid | CH4 | Methane-aerobic | Cofactor Alcohol | Aerobic oxidation | Vitamin B | serine cycle | Aliphatic Glycine hydroxymethyltransferase|Serine hydroxymethyltransferase gmd 0.0 0.0 0.0 2.0 1.0 0.0 0.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 0.0 2.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 1.0 0.0 1.0 2.0 1.0 0.0 1.0 Organic Degration | Organic Biosynthesis Carbohydrate Monosaccharide | Glycan GDP-mannose 4,6 dehydratase gmhA 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 Organic Transformation Glycan Lipopolysaccharide Phosphoheptose isomerase gmhC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Transformation Glycan Lipopolysaccharide D-beta-D-heptose 7-phosphate kinase|D-beta-D-heptose 1-phosphate adenylyltransferase gmhD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Transformation Glycan Lipopolysaccharide ADP-L-glycero-D-manno-heptose-6-epimerase gmk 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 2.0 1.0 1.0 1.0 1.0 1.0 Organic Degration | Organic Biosynthesis Organophosphorus compound | Nucleotide Purine | Purine metabolism Guanylate kinase gnd 2.0 1.0 0.0 0.0 1.0 2.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 2.0 0.0 0.0 Organic Degration | Carbon Fixation | Carbon Release | Organic Biosynthesis Carbohydrate | CO2 | Photosynthesis | Organophosphorus compound Calvin cycle | Pentose phosphate | Monosaccharide | Calvin-Benson-Bassham Cycle | CO2 | Pentose phosphate pathway 6-phosphogluconate dehydrogenase gnl 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Xenobiotics | Organophosphorus compound | Carbohydrate Monosaccharide | Pentose phosphate pathway | Pentose phosphate | Plastics Gluconolactonase gntK 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Organophosphorus compound | Carbohydrate Monosaccharide | Pentose phosphate pathway | Pentose phosphate Gluconokinase gox 0.0 1.0 0.0 1.0 1.0 4.0 0.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 3.0 1.0 0.0 1.0 1.0 3.0 1.0 0.0 1.0 0.0 0.0 1.0 6.0 2.0 5.0 0.0 3.0 1.0 Organic Transformation | Organic Degration Xenobiotics Lignin Glycolate oxidase gpmA 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 Organic Degration Carbohydrate Glycolysis 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase gpmB 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 4.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Carbon Fixation | Organic Degration Carbohydrate | CH4 | Methane-aerobic Aerobic oxidation | serine cycle | Glycolysis Phosphoglycerate mutase gpmI 1.0 2.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 Carbon Fixation | Organic Degration Carbohydrate | CH4 | Methane-aerobic Aerobic oxidation | serine cycle | Glycolysis Phosphoglycerate mutase gpsA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Biosynthesis Lipid Fatty acid Glycerol-3-phosphate dehydrogenase [NAD(P)+] gpt 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Amino acid | Nucleotide Purine | Aliphatic Xanthine-guanine phosphoribosyltransferase gpx 0.0 1.0 2.0 2.0 2.0 1.0 0.0 1.0 1.0 0.0 1.0 1.0 1.0 4.0 2.0 1.0 1.0 2.0 1.0 1.0 0.0 2.0 2.0 0.0 0.0 0.0 1.0 3.0 1.0 1.0 2.0 1.0 0.0 Organic Transformation | Organic Degration Xenobiotics Lignin Glutathione peroxidase griH 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 gs_K00264 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Nitrogen cycle Organic degradation and synthesis Glutamate synthase (NADPH/NADH) gs_K00265 1.0 0.0 0.0 0.0 0.0 3.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 Organic Degration Nitrogen cycle Organic degradation and synthesis Glutamate synthase (NADPH/NADH) large chain gs_K00266 0.0 1.0 1.0 0.0 1.0 2.0 1.0 2.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 0.0 1.0 1.0 0.0 2.0 3.0 2.0 2.0 1.0 0.0 0.0 0.0 2.0 2.0 2.0 2.0 2.0 0.0 Organic Degration Nitrogen cycle Organic degradation and synthesis Glutamate synthase (NADPH/NADH) small chain gs_K00284 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 Organic Degration Nitrogen cycle Organic degradation and synthesis Glutamate synthase (ferredoxin) gshB 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 gsiA 0.0 0.0 0.0 0.0 0.0 5.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.0 0.0 0.0 0.0 Transport ABC transport ABC transport Glutathione import ATP-binding protein gsiC 0.0 0.0 0.0 0.0 0.0 5.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport ABC transport ABC transport Glutathione transport system permease protein gsiD 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport ABC transport ABC transport Glutathione transport system permease protein gtfD 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Biosynthesis Carbohydrate | Antibiotic Glycopeptide | Carbohydrate Glucosyltransferase guaA 1.0 2.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 1.0 0.0 1.0 2.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 2.0 3.0 1.0 2.0 1.0 1.0 Organic Degration | Organic Biosynthesis Organophosphorus compound | Nucleotide Purine | Purine metabolism GMP synthase [glutamine-hydrolyzing] guaB 1.0 1.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 4.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 3.0 0.0 1.0 2.0 2.0 0.0 1.0 1.0 2.0 1.0 2.0 1.0 1.0 1.0 Organic Degration | Organic Biosynthesis Organophosphorus compound | Nucleotide Purine | Purine metabolism Inosine-5'-monophosphate dehydrogenase guaC 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Nucleotide Purine GMP reductase hadH 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics Lignin 3-hydroxyacyl-CoA dehydrogenase hcaC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics Lignin 3-phenylpropionate/cinnamic acid dioxygenase ferredoxin subunit hcaD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics | Lipid Lignin | Fatty acid 3-phenylpropionate/cinnamic acid dioxygenase ferredoxin--NAD(+) reductase component hcp 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Nitrogen cycle Auxiliary Hydroxylamine reductase hcrC2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics Lignin 4-hydroxybenzoyl-CoA reductase subunit gamma 2 hcxB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 hddA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Transformation Glycan Lipopolysaccharide D-glycero-alpha-D-manno-heptose 7-phosphate kinase hdrD 0.0 1.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 Carbon Fixation | Carbon Release | Organic Degration Organic sulfur cycle | Methane-anaerobic | CH4 Anaerobic oxidation of methane | Link between inorganic and organic sulfur transformation | Central methanogenic pathway heterodisulfide reductase subunit D hemA 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 2.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 1.0 0.0 Organic Biosynthesis Cofactor Vitamin B | Porphyrin Glutamyl-tRNA reductase hemB 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 2.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 Organic Biosynthesis Cofactor Vitamin B | Porphyrin Delta-aminolevulinic acid dehydratase hemC 1.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 2.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 Organic Biosynthesis Cofactor Vitamin B | Porphyrin Porphobilinogen deaminase hemE 1.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 Carbon Release | Organic Biosynthesis CO2 | Cofactor CO2 | Porphyrin Uroporphyrinogen decarboxylase hemF 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 Carbon Release | Organic Biosynthesis CO2 | Cofactor CO2 | Porphyrin Oxygen-dependent coproporphyrinogen-III oxidase hemJ 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Porphyrin Protoporphyrinogen IX oxidase hemL 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 2.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 1.0 0.0 1.0 2.0 1.0 2.0 1.0 0.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 0.0 Organic Biosynthesis Cofactor Vitamin B | Porphyrin Glutamate-1-semialdehyde 2,1-aminomutase hemN 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 Carbon Release | Organic Biosynthesis CO2 | Cofactor CO2 | Porphyrin Oxygen-independent coproporphyrinogen III oxidase hemX 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Porphyrin Uroporphyrinogen-III C-methyltransferase hemY 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Porphyrin Coproporphyrinogen III oxidase hisA 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 2.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 1.0 0.0 0.0 Organic Biosynthesis Amino acid Cationic 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase hisB 1.0 0.0 1.0 0.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 2.0 1.0 0.0 0.0 Organic Biosynthesis Amino acid Cationic Histidinol-phosphatase|Imidazoleglycerol-phosphate dehydratase hisC 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 Organic Degration | Organic Biosynthesis Amino acid | Secondary metabolite | Antibiotic Antibiotic | Secondary metabolite | Cationic | Aromatic | Aliphatic Histidinol-phosphate aminotransferase hisD 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Amino acid Cationic Histidinol dehydrogenase hisE 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Amino acid Cationic Phosphoribosyl-ATP pyrophosphatase hisF 1.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 Organic Biosynthesis Amino acid Cationic Imidazole glycerol phosphate synthase hisG 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 hisI 1.0 0.0 0.0 0.0 0.0 2.0 0.0 2.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 2.0 1.0 1.0 1.0 0.0 0.0 Organic Biosynthesis Amino acid Cationic Phosphoribosyl-AMP cyclohydrolase|Phosphoribosyl-ATP pyrophosphatase hisM 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport ABC transport ABC transport Histidine transport system permease protein hisP 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 Transport ABC transport ABC transport Histidine transport ATP-binding protein hisQ 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Transport ABC transport ABC transport Histidine transport system permease protei hldE 0.0 2.0 1.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 1.0 0.0 1.0 1.0 1.0 Organic Transformation Glycan Lipopolysaccharide D-beta-D-heptose 7-phosphate kinase|D-beta-D-heptose 1-phosphate adenylyltransferase hmgA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics Lignin | Styrene Homogentisate 1,2-dioxygenase hom 1.0 1.0 0.0 0.0 0.0 2.0 0.0 1.0 0.0 1.0 0.0 2.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 Organic Biosynthesis Amino acid L-Amino acid | S side-chain | Cationic Homoserine dehydrogenase hpaC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics | Cofactor Lignin | Vitamin B 4-hydroxyphenylacetate 3-monooxygenase reductase component hpaD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 hpaE 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 hpcH 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 1.0 0.0 Organic Transformation | Organic Degration Xenobiotics Lignin 4-hydroxy-2-oxo-heptane-1,7-dioate aldolase hpd 0.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 2.0 0.0 1.0 1.0 1.0 0.0 2.0 0.0 0.0 1.0 1.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 Organic Transformation | Organic Degration Xenobiotics Lignin 4-hydroxyphenylpyruvate dioxygenase hprA 0.0 0.0 0.0 0.0 0.0 1.0 0.0 2.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 3.0 0.0 0.0 0.0 0.0 1.0 2.0 1.0 0.0 1.0 0.0 2.0 0.0 Carbon Fixation | Organic Degration CH4 | Methane-aerobic Aerobic oxidation | serine cycle Glycerate dehydrogenase hpsN 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Organic sulfur cycle Organic sulfur transformation Sulfopropanediol 3-dehydrogenase hpt 2.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 Organic Degration | Organic Biosynthesis Nucleotide Purine Hypoxanthine phosphoribosyltransferase hrtB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 Transport ABC transport ABC transport Hemin transport system permease protein hsaB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 hupU 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Transport | Organic Degration Aromatics | Two-component system Aromatics | Two-component system Hydrogenase hutF 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 hutH 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 2.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 hutI 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 hutU 0.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 hxpB 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Carbohydrate Monosaccharide Hexitol phosphatase hyaA 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Transport | Organic Degration Aromatics | Two-component system Aromatics | Two-component system Hydrogenase hyaB 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Transport | Organic Degration Aromatics | Two-component system Aromatics | Two-component system Hydrogenase hybC 2.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 Transport | Organic Degration Xenobiotics | Aromatics | Two-component system Aromatics | Lignin | Two-component system Hydrogenase-2 large chain hybD 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 Organic Degration Xenobiotics Lignin Hydrogenase 2 maturation protease hyi 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 hyuB 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Biosynthesis Amino acid Cationic N-methylhydantoinase icd 3.0 2.0 2.0 1.0 2.0 2.0 2.0 1.0 2.0 1.0 1.0 1.0 0.0 1.0 2.0 1.0 3.0 1.0 1.0 1.0 2.0 2.0 3.0 1.0 1.0 2.0 1.0 2.0 1.0 2.0 2.0 1.0 1.0 Carbon Release | Organic Degration Carbohydrate | CO2 Citrate cycle | CO2 Isocitrate dehydrogenase [NADP] icdA 1.0 1.0 1.0 0.0 1.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 1.0 Carbon Release | Organic Degration Carbohydrate | CO2 Citrate cycle | CO2 Isocitrate dehydrogenase [NADP] ilvA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Amino acid Alcohol | Aliphatic L-threonine dehydratase biosynthetic ilvB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Carbon Release | Organic Biosynthesis CO2 | Amino acid Aliphatic | CO2 Acetolactate synthase ilvC 1.0 0.0 1.0 0.0 1.0 2.0 1.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 Organic Biosynthesis Amino acid Aliphatic Ketol-acid reductoisomerase ilvD 1.0 0.0 2.0 0.0 1.0 1.0 1.0 1.0 0.0 2.0 1.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 2.0 1.0 1.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 Organic Biosynthesis Amino acid Aliphatic Dihydroxy-acid dehydratase ilvG 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Carbon Release | Organic Biosynthesis CO2 | Amino acid Aliphatic | CO2 Acetolactate synthase ilvN 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Carbon Release | Organic Biosynthesis CO2 | Amino acid Aliphatic | CO2 Acetolactate synthase inhA 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration Xenobiotics Plastics Isonitrile hydratase inuJ 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 iolA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 2.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Carbon Release CO2 CO2 Malonate-semialdehyde dehydrogenase iorA 0.0 0.0 0.0 1.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 4.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Carbon Release | Organic Degration Xenobiotics | CO2 CO2 | Lignin Indolepyruvate oxidoreductase subunit ipdC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Release | Organic Biosynthesis Xenobiotics | CO2 Others | CO2 Indole-3-pyruvate decarboxylase iscS 0.0 2.0 2.0 2.0 2.0 2.0 0.0 0.0 2.0 1.0 2.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 2.0 2.0 0.0 2.0 2.0 0.0 Organic Biosynthesis Cofactor Vitamin B Cysteine desulfurase isfD 0.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 3.0 1.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 1.0 Organic Degration Organic sulfur cycle Organic sulfur transformation Isethionate dehydrogenase ispA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Secondary metabolite Terpenoid Farnesyl diphosphate synthase ispD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 Organic Biosynthesis Secondary metabolite Terpenoid 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase ispDF 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 2.0 1.0 1.0 1.0 1.0 1.0 Organic Biosynthesis Secondary metabolite Terpenoid 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase|2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispE 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 Organic Biosynthesis Secondary metabolite Terpenoid 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase ispF 0.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 1.0 1.0 Organic Biosynthesis Secondary metabolite Terpenoid 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispG 2.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 3.0 1.0 1.0 1.0 0.0 2.0 2.0 2.0 2.0 2.0 1.0 1.0 Organic Biosynthesis Secondary metabolite Terpenoid 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase ispH 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 1.0 0.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 Organic Biosynthesis Secondary metabolite Terpenoid 4-hydroxy-3-methylbut-2-enyl diphosphate reductase iucD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 ivd 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 kal 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Amino acid L-Amino acid 3-aminobutyryl-CoA ammonia lyase kamE 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation Amino acid D-Amino acid Lysine 5,6-aminomutase katG 0.0 1.0 1.0 1.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 1.0 Organic Degration | Carbon Release | Organic Transformation | Organic Biosynthesis Antibiotic | Xenobiotics | CO2 | Secondary metabolite | Amino acid Antibiotic | CO2 | Secondary metabolite | Aromatic | Aliphatic | Lignin Catalase-peroxidase kauB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Amino acid Cationic 4-guanidinobutyraldehyde dehydrogenase kbl 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 1.0 0.0 1.0 Organic Biosynthesis Cofactor Vitamin B 2-amino-3-ketobutyrate coenzyme A ligase|8-amino-7-oxononanoate synthase 1 kce 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Degration Amino acid L-Amino acid 3-keto-5-aminohexanoate cleavage enzyme kdd 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Amino acid L-Amino acid L-erythro-3,5-diaminohexanoate dehydrogenase kdkA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation Glycan Lipopolysaccharide 3-deoxy-D-manno-octulosonic acid kinase kdsA 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 0.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Organic Transformation Glycan Lipopolysaccharide 2-dehydro-3-deoxyphosphooctonate aldolase kdsB 1.0 2.0 0.0 2.0 2.0 0.0 0.0 1.0 1.0 0.0 1.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 Organic Transformation Glycan Lipopolysaccharide 3-deoxy-manno-octulosonate cytidylyltransferase|8-amino-3,8-dideoxy-manno-octulosonate cytidylyltransferase kdsC 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation Glycan Lipopolysaccharide 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase kdtB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Coenzyme Phosphopantetheine adenylyltransferase kgd 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Release CO2 CO2 2-hydroxy-3-oxoadipate synthase|2-oxoglutarate dehydrogenase korA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Carbon Fixation | Carbon Release | Organic Biosynthesis Carbohydrate | CO2 Citrate cycle | Fermentation | Glycolysis | CO2 | Reductive tricarboxylic acid cycle | Pyruvate 2-oxoglutarate synthase ldh 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Carbohydrate Fermentation | Pyruvate | Glycolysis L-lactate dehydrogenase ldhA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Carbohydrate Fermentation | Pyruvate D-lactate dehydrogenase leuB 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 1.0 2.0 0.0 Carbon Release | Organic Biosynthesis CO2 | Amino acid Aliphatic | CO2 3-isopropylmalate dehydrogenase leuC 1.0 0.0 1.0 0.0 1.0 5.0 1.0 1.0 0.0 1.0 1.0 3.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 2.0 1.0 1.0 0.0 0.0 1.0 2.0 1.0 1.0 1.0 2.0 0.0 Organic Degration | Organic Biosynthesis Amino acid Aliphatic 3-isopropylmalate dehydratase|Isopropylmalate/citramalate isomerase leuD 1.0 0.0 1.0 0.0 1.0 2.0 1.0 1.0 0.0 1.0 1.0 2.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 2.0 1.0 1.0 1.0 2.0 0.0 Organic Degration | Organic Biosynthesis Amino acid Aliphatic 3-isopropylmalate dehydratase|Isopropylmalate/citramalate isomerase lgaA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 lhgO 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 lhpC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Amino acid D-Amino acid 1-pyrroline-4-hydroxy-2-carboxylate deaminase lhpD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Amino acid Cationic | D-Amino acid Delta(1)-pyrroline-2-carboxylate/Delta(1)-piperideine-2-carboxylate reductase ligC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Aromatics Aromatics | Lignin 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase ligH 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics Lignin Formate--tetrahydrofolate ligase ligJ 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Transformation | Organic Degration Xenobiotics | Aromatics Aromatics | Lignin 4-oxalomesaconate hydratase lipA 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 1.0 1.0 Organic Biosynthesis Cofactor Coenzyme Lipoyl synthase lipB 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 1.0 1.0 2.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 2.0 1.0 1.0 Organic Biosynthesis Cofactor Coenzyme Octanoyltransferase liuC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 livF 2.0 0.0 0.0 0.0 0.0 11.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 6.0 0.0 6.0 0.0 14.0 0.0 Transport ABC transport ABC transport High-affinity branched-chain amino acid transport ATP-binding protein livH 1.0 0.0 0.0 0.0 0.0 4.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 0.0 2.0 0.0 Transport ABC transport ABC transport High-affinity branched-chain amino acid transport system permease protein livK 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 3.0 0.0 1.0 0.0 0.0 0.0 Transport ABC transport ABC transport Amino acid ABC transporter substrate-binding protein livM 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport ABC transport ABC transport Branched-chain amino acid transport permease protein|High-affinity branched-chain amino acid transport system permease protein lldD 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 3.0 0.0 1.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 2.0 0.0 2.0 0.0 1.0 0.0 3.0 0.0 Organic Degration | Organic Biosynthesis Carbohydrate Fermentation | Pyruvate L-lactate dehydrogenase lolD 2.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 2.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 2.0 0.0 1.0 1.0 2.0 0.0 0.0 2.0 3.0 2.0 2.0 1.0 2.0 2.0 2.0 Transport ABC transport ABC transport Lipoprotein-releasing system ATP-binding protein lpcA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 Organic Transformation Glycan Lipopolysaccharide Phosphoheptose isomerase lpdA 1.0 1.0 1.0 0.0 1.0 3.0 2.0 2.0 2.0 1.0 1.0 2.0 3.0 2.0 2.0 1.0 1.0 2.0 2.0 1.0 2.0 1.0 2.0 1.0 0.0 2.0 1.0 2.0 1.0 2.0 1.0 2.0 1.0 Organic Degration Carbohydrate Citrate cycle 2-oxoglutarate dehydrogenase E3 component lplJ 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Biosynthesis Protein | Cofactor Protein | Coenzyme Lipoate-protein ligase lpqY 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport ABC transport ABC transport Trehalose-binding lipoprotein lptB 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 1.0 0.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 Transport ABC transport ABC transport Lipopolysaccharide export system ATP-binding protein lpxA 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 1.0 Organic Transformation Glycan Lipopolysaccharide Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase lpxB 1.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 Organic Transformation Glycan Lipopolysaccharide Lipid-A-disaccharide synthase lpxC 3.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 2.0 1.0 1.0 Organic Transformation Glycan Lipopolysaccharide UDP-3-O-acyl-N-acetylglucosamine deacetylase lpxD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Transformation Glycan Lipopolysaccharide UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase|UDP-3-O-acylglucosamine N-acyltransferase lpxH 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 Organic Transformation Glycan Lipopolysaccharide UDP-2,3-diacylglucosamine hydrolase lpxK 0.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 0.0 2.0 0.0 1.0 0.0 0.0 0.0 0.0 2.0 0.0 1.0 1.0 1.0 0.0 Organic Transformation Glycan Lipopolysaccharide Tetraacyldisaccharide 4'-kinase lpxO 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Degration Carbohydrate Lipopolysaccharide Beta-hydroxylase|Lipid A hydroxylase ltaA 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 1.0 0.0 Organic Degration | Organic Biosynthesis Amino acid Alcohol L-allo-threonine aldolase ltaE 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Amino acid Alcohol Low specificity L-threonine aldolase lysA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 Carbon Release | Organic Biosynthesis CO2 | Amino acid L-Amino acid | CO2 | Cationic Diaminopimelate decarboxylase lysX 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Amino acid Cationic Lysylphosphatidylglycerol biosynthesis maeA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport | Carbon Release | Organic Biosynthesis Carbohydrate | CO2 | Two-component system CO2 | Pyruvate | Two-component system Malate dehydrogenase malF 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport ABC transport ABC transport Transport system permease protein malG 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport ABC transport ABC transport Transport system permease protein malK 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 10.0 0.0 0.0 0.0 Transport Two-component system | ABC transport Two-component system | ABC transport Trehalose/maltose import ATP-binding protein|Maltose/maltodextrin import ATP-binding protein malP 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 malQ 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Carbohydrate Starch 4-alpha-glucanotransferase manA 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Carbohydrate Monosaccharide | Mannose Mannose-6-phosphate isomerase manC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 Organic Degration | Organic Biosynthesis Carbohydrate Monosaccharide Mannose-1-phosphate guanylyltransferase mapA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Carbohydrate | Protein Starch | Protein Methionine aminopeptidase matB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 mauA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 Carbon Fixation | Organic Degration CH4 | Methane-aerobic Oxidation of merthane and C1 compounds | Aerobic oxidation Methylamine dehydrogenase mauD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Carbon Fixation | Organic Degration CH4 | Methane-aerobic Oxidation of merthane and C1 compounds | Aerobic oxidation Methylamine dehydrogenase mbhJ 2.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Release CH4 Central methanogenic pathway Membrane-bound hydrogenase mccB 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Organic sulfur cycle | Amino acid S side-chain | Link between inorganic and organic sulfur transformation Cystathionine gamma-lyase / homocysteine desulfhydrase mcd 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 Carbon Fixation | Organic Biosynthesis CO2 | Cofactor 3-Hydroxypropionate Bicycle | Coenzyme (2S)-methylsuccinyl-CoA dehydrogenase mch 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Fixation | Carbon Release | Organic Degration Methane-anaerobic | CH4 | Methane-aerobic Anaerobic oxidation of methane | Aerobic oxidation | Oxidation of formaldehyde | Hydrogenotrophic methanogenesis Methenyltetrahydromethanopterin cyclohydrolase mch-K14449 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration | Carbon Fixation | Organic Biosynthesis CO2 | Cofactor 3-Hydroxypropionate Bicycle | Coenzyme Beta-methylmalyl-CoA dehydratase mcl 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 Carbon Fixation | Organic Degration Carbohydrate | CO2 | CH4 | Methane-aerobic Pyruvate | Aerobic oxidation | 3-Hydroxypropionate Bicycle | serine cycle Malyl-CoA/(S)-citramalyl-CoA lyase mcl2 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 mcmA1 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 Carbon Fixation CO2 3-Hydroxypropionate Bicycle | 3-Hydroxypropionate/4-Hydroxybutyrate Cycle Methylmalonyl-CoA mutase mcr-K01796 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation Carbohydrate Carbohydrate Alpha-methylacyl-CoA racemase mct 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Coenzyme Succinyl-CoA:mesaconate CoA-transferase mct-K14470 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Fixation CO2 3-Hydroxypropionate Bicycle 2-methylfumaryl-CoA isomerase mddA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Organic sulfur cycle | DMSP catabolic pathway Organic sulfur transformation | DMS synthesis Methanethiol S-methyltransferase mdh 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Carbon Fixation | Organic Degration Carbohydrate | CH4 | Methane-aerobic Oxidation of merthane and C1 compounds | Aerobic oxidation | Fermentation NAD-dependent methanol dehydrogenase mdh-K00024 0.0 2.0 2.0 3.0 2.0 1.0 1.0 1.0 1.0 0.0 2.0 0.0 1.0 2.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 Carbon Fixation | Organic Degration Methane-aerobic | Organic sulfur cycle | CH4 | Carbohydrate | CO2 Citrate cycle | Aerobic oxidation | Organic sulfur transformation | serine cycle | Glyoxylate cycle | Dicarboxylate/4-hydroxybutyrate cycle Malate dehydrogenase mdlC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Carbon Release | Organic Transformation | Organic Degration Xenobiotics | CO2 | Aromatics CO2 | Lignin | Aromatics Benzoylformate decarboxylase mdo 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Carbon Fixation | Organic Degration Xenobiotics | CH4 | Methane-aerobic Organic pollutant | Aerobic oxidation | Oxidation of formaldehyde Formaldehyde dismutase / methanol dehydrogenase melA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Carbohydrate | Lipid Galactose | Pectin | Alpha-galactans | Monosaccharide | Starch | Fatty acid | Xylan | Xyloglucan | Hemicellulose Alpha-galactosidase menA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Release | Organic Biosynthesis CO2 | Cofactor CO2 | Vitamin K | Coenzyme 1,4-dihydroxy-2-naphthoate octaprenyltransferase|2-carboxy-1,4-naphthoquinone phytyltransferase menB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 Organic Biosynthesis Cofactor Vitamin K | Coenzyme 1,4-dihydroxy-2-naphthoyl-CoA synthase menC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin K | Coenzyme o-succinylbenzoate synthase menD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Carbon Release | Organic Biosynthesis CO2 | Cofactor CO2 | Vitamin K | Coenzyme 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase menE 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin K | Coenzyme 2-succinylbenzoate--CoA ligase menF 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Cofactor Vitamin K | Coenzyme Isochorismate synthase menG-EC4.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 menI 0.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin K | Coenzyme 1,4-dihydroxy-2-naphthoyl-CoA hydrolas metA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Organic sulfur cycle | Amino acid L-Amino acid | S side-chain | Link between inorganic and organic sulfur transformation Homoserine O-succinyltransferase/ O-acetyltransferase metB 0.0 2.0 2.0 2.0 3.0 2.0 2.0 1.0 2.0 3.0 2.0 1.0 0.0 2.0 1.0 1.0 3.0 0.0 0.0 0.0 2.0 3.0 2.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Xenobiotics | Organic sulfur cycle Selenocompound | Link between inorganic and organic sulfur transformation Cystathionine gamma-synthase metC 0.0 2.0 3.0 3.0 2.0 1.0 2.0 0.0 2.0 0.0 1.0 2.0 1.0 2.0 2.0 0.0 2.0 2.0 1.0 0.0 0.0 1.0 2.0 2.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 1.0 Organic Degration | Organic Biosynthesis Xenobiotics | Organic sulfur cycle Selenocompound | Link between inorganic and organic sulfur transformation Cystathionine beta-lyase metE 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Biosynthesis Xenobiotics | Amino acid Selenocompound | S side-chain | Se 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase|Methionine synthase metF 0.0 0.0 0.0 0.0 0.0 2.0 1.0 1.0 1.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 2.0 1.0 1.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 Carbon Fixation | Carbon Release | Organic Degration Methane-anaerobic | CO2 | CH4 | Cofactor Anaerobic oxidation of methane | Vitamin B | Reductive acetyl-CoA pathway | Hydrogenotrophic methanogenesis 5,10-methylenetetrahydrofolate reductase metG 1.0 1.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 2.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 Organic Transformation Protein Protein Methionine--tRNA ligase metH 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Xenobiotics | Amino acid | Cofactor Selenocompound | S side-chain | Se | Vitamin B Methionine synthase metI 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Transport ABC transport ABC transport D-methionine transport system permease protein metK 0.0 1.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Organic Biosynthesis Amino acid S side-chain S-adenosylmethionine synthase metN 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Transport ABC transport ABC transport Methionine import ATP-binding protein metV 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Fixation CO2 Reductive acetyl-CoA pathway Methylenetetrahydrofolate reductase metX 0.0 0.0 0.0 0.0 0.0 2.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 2.0 0.0 Organic Degration | Organic Biosynthesis Organic sulfur cycle | Amino acid L-Amino acid | Alcohol | Link between inorganic and organic sulfur transformation | S side-chain Homoserine O-acetyltransferase/O-succinyltransferase metY 0.0 1.0 0.0 0.0 0.0 4.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 3.0 1.0 1.0 0.0 1.0 0.0 Organic Degration | Organic Biosynthesis Organic sulfur cycle | Amino acid S side-chain | Link between inorganic and organic sulfur transformation O-acetyl-L-homoserine sulfhydrylase metZ 0.0 0.0 1.0 0.0 0.0 3.0 1.0 0.0 1.0 1.0 1.0 1.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Organic sulfur cycle | Amino acid S side-chain | Link between inorganic and organic sulfur transformation O-succinylhomoserine sulfhydrylase mftC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Release CO2 CO2 Mycofactocin maturas mftD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 mgdA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Lipid | CH4 | Methane-aerobic Oxidation of merthane and C1 compounds | Aerobic oxidation | Fatty acid 1,2-diacylglycerol 3-glucosyltransferase mgsA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Carbon Fixation | Organic Degration CH4 | Methane-aerobic Oxidation of merthane and C1 compounds | Aerobic oxidation Methylamine---glutamate N-methyltransferase mgsA-EC4.2.3.3 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 mgsB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Carbon Fixation | Organic Degration CH4 | Methane-aerobic Oxidation of merthane and C1 compounds | Aerobic oxidation Methylamine---glutamate N-methyltransferase mgsC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Carbon Fixation | Organic Degration CH4 | Methane-aerobic Oxidation of merthane and C1 compounds | Aerobic oxidation Methylamine---glutamate N-methyltransferase mhbD 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics Lignin Gentisate 1,2-dioxygenase mhbM 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics Lignin 3-hydroxybenzoate 6-hydroxylase mhpB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics Lignin 2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase mhpC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics Lignin 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase mhpD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics | Aromatics Organic pollutant | Aromatics | Lignin 2-keto-4-pentenoate hydratase mhpE 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 1.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics | Aromatics Organic pollutant | Aromatics | Lignin 4-hydroxy-2-oxovalerate aldolase mhpF 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Transformation | Organic Biosynthesis Xenobiotics | Carbohydrate | Aromatics Organic pollutant | Aromatics | Lignin | Pyruvate Acetaldehyde dehydrogenase mhpR 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics Lignin DNA-binding transcriptional activator mhpT 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics Lignin 3-(3-hydroxy-phenyl)propionate transporter mkl 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 Transport ABC transport ABC transport Ribonucleotide transport ATP-binding protein mlaD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 Transport ABC transport ABC transport Phospholipid transport system binding protein mlaE 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 0.0 0.0 Transport ABC transport ABC transport Phospholipid transport system permease protein mlaF 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 Transport ABC transport ABC transport Phospholipid transport system ATP-binding protein mmcO 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Porphyrin Multicopper oxidase mmoC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 Carbon Fixation | Organic Degration CH4 | Methane-aerobic Oxidation of merthane and C1 compounds | Aerobic oxidation Methane monooxygenase mntB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 1.0 0.0 0.0 0.0 Transport Two-component system | ABC transport Two-component system | ABC transport Manganese transport system membrane protein|Manganese transport system ATP-binding protein mntD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport ABC transport ABC transport Manganese transport system membrane protein moaA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 Organic Biosynthesis Cofactor Vitamin B GTP 3',8-cyclase moaC 1.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 2.0 0.0 1.0 0.0 2.0 1.0 2.0 1.0 1.0 0.0 2.0 0.0 1.0 1.0 1.0 0.0 2.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Organic Biosynthesis Cofactor Vitamin B Cyclic pyranopterin monophosphate synthase moaE 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 6.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 2.0 1.0 0.0 1.0 0.0 Organic Biosynthesis Cofactor Vitamin B Molybdopterin synthase mobA-K03752 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.0 0.0 1.0 1.0 1.0 0.0 Organic Biosynthesis Cofactor Vitamin B Molybdenum cofactor guanylyltransferase modA 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Transport ABC transport ABC transport Molybdate ABC transporter substrate-binding protein modB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 Transport ABC transport ABC transport Molybdenum transport system permease protein modC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport ABC transport ABC transport Molybdenum transport system permease mogA 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 2.0 0.0 0.0 0.0 1.0 0.0 Organic Biosynthesis Cofactor Vitamin B Molybdopterin adenylyltransferase mptA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Biosynthesis Glycan | Cofactor Glycolipid | Vitamin B | Lipoarabinomannan Alpha-(1->6)-mannopyranosyltransferase mptB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Biosynthesis Glycan | Cofactor Glycolipid | Vitamin B | Lipoarabinomannan Alpha-(1->6)-mannopyranosyltransferase mqo 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Carbohydrate Pyruvate Malate:quinone oxidoreductase mraY 1.0 2.0 2.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 2.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Organic Transformation Glycan Peptidoglycan Phospho-N-acetylmuramoyl-pentapeptide-transferase mrcA 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 Organic Transformation Glycan Peptidoglycan Penicillin-binding protein 1A mrdA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Transformation Glycan Peptidoglycan Peptidoglycan D,D-transpeptidase mtbC 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Release CH4 Methylotrophic methanogenesis Dimethylamine methyltransferase mtgA-K03814 0.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 2.0 1.0 1.0 0.0 1.0 1.0 1.0 2.0 0.0 1.0 2.0 1.0 0.0 1.0 2.0 0.0 1.0 Organic Transformation | Organic Biosynthesis Glycan Peptidoglycan Biosynthetic peptidoglycan transglycosylase mtkA 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 0.0 1.0 1.0 0.0 1.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 Carbon Fixation | Organic Degration CH4 | Methane-aerobic Aerobic oxidation | serine cycle Malate-CoA ligase mtkB 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Fixation | Organic Degration CH4 | Methane-aerobic Aerobic oxidation | serine cycle Malate-CoA ligase mtlK 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration Carbohydrate Monosaccharide Mannitol 2-dehydrogenase mtlK-trans 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Transport ABC transport ABC transport Multiple sugar transport system ATP-binding protein mtnA 1.0 0.0 0.0 0.0 0.0 2.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 1.0 1.0 0.0 1.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 0.0 Organic Biosynthesis Amino acid S side-chain Methylthioribose-1-phosphate isomerase mtnE 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Amino acid S side-chain L-glutamine--4-(methylsulfanyl)-2-oxobutanoate aminotransferase mtnN 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Amino acid S side-chain Aminodeoxyfutalosine nucleosidase murA 1.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 Organic Transformation | Organic Biosynthesis Glycan Peptidoglycan UDP-N-acetylglucosamine 1-carboxyvinyltransferase murB 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Transformation | Organic Biosynthesis Glycan Peptidoglycan UDP-N-acetylenolpyruvoylglucosamine reductase murC 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 1.0 0.0 Organic Transformation | Organic Biosynthesis Glycan Peptidoglycan UDP-N-acetylmuramate--L-alanine ligase murD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Biosynthesis Glycan | Amino acid Peptidoglycan | D-Amino acid UDP-N-acetylmuramoylalanine--D-glutamate ligase murG 1.0 1.0 1.0 1.0 1.0 2.0 0.0 0.0 1.0 2.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 1.0 0.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 Organic Transformation | Organic Biosynthesis Glycan Peptidoglycan UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase murI 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Transformation | Organic Biosynthesis Amino acid Anionic | D-Amino acid Glutamate racemase murL 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Biosynthesis Glycan Peptidoglycan UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate epimerase murQ 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 murU 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 mvaA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Biosynthesis Secondary metabolite Terpenoid 3-hydroxy-3-methylglutaryl-coenzyme A reductase|Hydroxymethylglutaryl-CoA reductase mvhA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Release CH4 Central methanogenic pathway F420-non-reducing hydrogenase mxaD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration | Carbon Fixation | Organic Transformation | Organic Biosynthesis Lipid | CH4 | Methane-aerobic Oxidation of merthane and C1 compounds | Polyketide | Aerobic oxidation Methanol dehydrogenase mxaF 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.0 0.0 1.0 0.0 0.0 0.0 Organic Degration | Carbon Fixation | Organic Transformation | Organic Biosynthesis Methane-aerobic | CH4 | Xenobiotics | Carbohydrate | Lipid Organic pollutant | Aerobic oxidation | Fermentation | Polyketide | Glycolysis | Oxidation of merthane and C1 compounds | Pyruvate Methanol dehydrogenase nadA 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 0.0 1.0 1.0 0.0 1.0 1.0 1.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B | Vitamin E Quinolinate synthase nadD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Cofactor Vitamin B | Vitamin E Nicotinate-nucleotide adenylyltransferase nadE 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 0.0 0.0 1.0 Organic Degration | Organic Biosynthesis Cofactor Vitamin B Glutamine-dependent NAD(+) synthetase|NH(3)-dependent NAD(+) synthetase nagB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Photosynthesis Calvin cycle Glucosamine-6-phosphate deaminase nagE 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport Phosphotransferase system Phosphotransferase system PTS system N-acetylglucosamine-specific EIICBA component nagG 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Aromatics Aromatics Salicylate 5-hydroxylase nagK 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 nagK-K16165 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 nagL 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 nagZ 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 1.0 0.0 Organic Degration Carbohydrate Chitin | Arabinose | Pectin | Arabinan | Xylan | Beta-galactans | Xyloglucan | Hemicellulose | Beta-mannan | Cellulose Beta-hexosaminidase nahK 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Carbon Release | Organic Degration Xenobiotics | CO2 | Aromatics Organic pollutant | CO2 | Aromatics 2-oxo-3-hexenedioate decarboxylase napA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 Organic Degration Nitrogen cycle Denitrification | Dissimilatory nitrate reduction Periplasmic nitrate reductase NapA napB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Nitrogen cycle Denitrification | Dissimilatory nitrate reduction Cytochrome c-type protein NapB napC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Nitrogen cycle Denitrification | Dissimilatory nitrate reduction Cytochrome c-type protein NapC napH 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Carbon Fixation | Organic Degration Methane-anaerobic | Secondary metabolite | CH4 | Antibiotic Anaerobic oxidation of methane | Secondary metabolite | Antibiotic Ferredoxin-type protein narB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 2.0 1.0 3.0 0.0 0.0 0.0 Carbon Fixation | Organic Degration Methane-anaerobic | Nitrogen cycle | CH4 Anaerobic oxidation of methane | Assimilatory nitrate reduction Assimilatory nitrate reductase narC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Nitrogen cycle Assimilatory nitrate reduction Cytochrome b-561 narG 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 2.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Transport | Carbon Fixation | Organic Degration Methane-anaerobic | Nitrogen cycle | CH4 | Two-component system Denitrification | Anaerobic oxidation of methane | Two-component system | Dissimilatory nitrate reduction Nitrate reductase narH 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 1.0 0.0 Transport | Carbon Fixation | Organic Degration Methane-anaerobic | Nitrogen cycle | CH4 | Two-component system Denitrification | Anaerobic oxidation of methane | Two-component system | Dissimilatory nitrate reduction Nitrate reductase narI 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 Organic Degration Nitrogen cycle Denitrification | Dissimilatory nitrate reduction Nitrate reductase gamma subunit narJ 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Degration Nitrogen cycle Denitrification | Dissimilatory nitrate reduction Nitrate reductase molybdenum cofactor assembly chaperone narV 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Degration Nitrogen cycle Denitrification | Dissimilatory nitrate reduction Nitrate reductase 2, gamma subunit narY 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Transport | Carbon Fixation | Organic Degration Methane-anaerobic | Nitrogen cycle | CH4 | Two-component system Denitrification | Anaerobic oxidation of methane | Two-component system | Dissimilatory nitrate reduction Nitrate reductase narZ 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Transport | Carbon Fixation | Organic Degration Methane-anaerobic | Nitrogen cycle | CH4 | Two-component system Denitrification | Anaerobic oxidation of methane | Two-component system | Dissimilatory nitrate reduction Nitrate reductase nasA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 Organic Degration Nitrogen cycle Assimilatory nitrate reduction Assimilatory nitrate reductase catalytic subunit nasD 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 Transport ABC transport ABC transport Nitrate transport protein ndh 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Carbohydrate Oxidative phosphorylation NADH:quinone oxidoreductase ndhD 0.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Carbohydrate Oxidative phosphorylation NAD(P)H-quinone oxidoreductase ndhE 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Carbohydrate Oxidative phosphorylation NAD(P)H-quinone oxidoreductase ndhF 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Carbohydrate | Cofactor Lignin | Vitamin B | Oxidative phosphorylation | Vitamin E Nicotine dehydrogenase|NAD(P)H-quinone oxidoreductase ndhK 0.0 0.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 2.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Carbohydrate Oxidative phosphorylation NAD(P)H-quinone oxidoreductase ndhS 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Cofactor Lignin | Vitamin B | Vitamin E Nicotinate dehydrogenase small FeS subunit ndk 0.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Organic Degration | Organic Biosynthesis Organophosphorus compound | Nucleotide Purine | Pyrimidine | Pyrimidine metabolism | Purine metabolism Nucleoside diphosphate kinase neuA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 Organic Degration | Organic Biosynthesis Xenobiotics | Glycan | Carbohydrate Others | Glycan | O-linked | Lipopolysaccharide N-acylneuraminate cytidylyltransferase nicF 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Degration Xenobiotics | Cofactor Lignin | Vitamin B | Vitamin E Maleamate amidohydrolase nifD 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Nitrogen cycle Nitrogen fixation Nitrogenase molybdenum-iron protein nifE 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 nifH 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 Organic Degration Nitrogen cycle Nitrogen fixation Nitrogenase iron protein nifJ 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Carbon Release | Organic Biosynthesis Carbohydrate | CO2 Citrate cycle | CO2 | Fermentation | Pyruvate Pyruvate ferredoxin oxidoreductase nifK 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Nitrogen cycle Nitrogen fixation Nitrogenase molybdenum-iron protein nifV 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Carbohydrate Pyruvate Homocitrate synthase nifW 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Nitrogen cycle Nitrogen fixation Nitrogenase-stabilizing/protective protein nirA 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 Organic Degration Nitrogen cycle Assimilatory nitrate reduction Ferredoxin--nitrite reductase nirB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 2.0 1.0 1.0 0.0 0.0 0.0 Organic Degration Nitrogen cycle Dissimilatory nitrate reduction Nitrite reductase nirD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 2.0 0.0 1.0 3.0 0.0 0.0 Organic Degration Nitrogen cycle | Cofactor Porphyrin | Dissimilatory nitrate reduction Siroheme decarboxylase nirD-EC1.7.1.15 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 2.0 0.0 1.0 0.0 0.0 0.0 nirK 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 1.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 1.0 2.0 0.0 0.0 Carbon Fixation | Organic Degration Methane-anaerobic | Nitrogen cycle | CH4 Denitrification | Anaerobic oxidation of methane Nitrite reductase (NO-forming) nirS 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 4.0 1.0 1.0 0.0 0.0 0.0 Carbon Fixation | Organic Degration Methane-anaerobic | Nitrogen cycle | CH4 Denitrification | Anaerobic oxidation of methane Nitrite reductase (NO-forming) nmo 1.0 1.0 1.0 1.0 1.0 4.0 0.0 1.0 0.0 9.0 1.0 5.0 2.0 1.0 2.0 0.0 1.0 0.0 2.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 4.0 5.0 2.0 0.0 5.0 1.0 Organic Degration Nitrogen cycle Organic degradation and synthesis Nitronate monooxygenase nocP 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Transport ABC transport ABC transport Nopaline permease ATP-binding protein nod 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Fixation | Organic Degration Methane-anaerobic | CH4 Anaerobic oxidation of methane NO dismutase nodE 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 nodI 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Transport ABC transport ABC transport Nod factor export ATP-binding protein nodJ 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Transport ABC transport ABC transport Nodulation protein|Transport permease protein norB 1.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 Organic Degration Nitrogen cycle Denitrification Nitric oxide reductase subunit B norC 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 Organic Degration Nitrogen cycle Denitrification Nitric oxide reductase subunit C nosZ 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 Organic Degration Nitrogen cycle Denitrification Nitrous-oxide reductase novW 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 npdA 0.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Cofactor Vitamin B NAD-dependent protein deacylase npr 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport Phosphotransferase system Phosphotransferase system Phosphocarrier protein nrdA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 2.0 0.0 0.0 1.0 0.0 Organic Degration | Organic Biosynthesis Organophosphorus compound | Nucleotide Purine | Pyrimidine | Pyrimidine metabolism Ribonucleoside-diphosphate reductase nrdB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Degration | Organic Biosynthesis Organophosphorus compound | Nucleotide Purine | Pyrimidine | Pyrimidine metabolism Ribonucleoside-diphosphate reductase nrdD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 Organic Degration | Carbon Release | Organic Biosynthesis Organophosphorus compound | CO2 | Nucleotide Purine | CO2 | Pyrimidine | Pyrimidine metabolism Anaerobic ribonucleoside-triphosphate reductase nrdE 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Organophosphorus compound | Nucleotide Purine | Pyrimidine | Pyrimidine metabolism Ribonucleoside-diphosphate reductase alpha chain nrdF 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Organophosphorus compound | Nucleotide Purine | Pyrimidine | Pyrimidine metabolism Ribonucleoside-diphosphate reductase beta chain nrdJ 0.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 1.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 1.0 2.0 0.0 0.0 Organic Degration | Organic Biosynthesis Organophosphorus compound | Nucleotide Pyrimidine | Pyrimidine metabolism Ribonucleotide reductase, class II nrfA 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Fixation | Organic Degration Methane-anaerobic | Nitrogen cycle | CH4 Anaerobic oxidation of methane | Dissimilatory nitrate reduction Nitrite reductase (cytochrome c-552) nrfC 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Nitrogen cycle Dissimilatory nitrate reduction Protein NrfC nrnA 0.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Inorganic sulfur transformation Assimilatory sulfate reduction Bifunctional oligoribonuclease and PAP phosphatase NrnA nrtA 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport ABC transport ABC transport Nitrate/nitrite binding protein|Nitrate transport nitrate-binding protein nrtB 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 Transport ABC transport ABC transport Nitrate import permease protein|Nitrate transport permease protein nrtD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport ABC transport ABC transport Nitrate import ATP-binding protein|Nitrate transport ATP-binding protein ntaB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration Cofactor Vitamin B FMN reductase nthA 0.0 0.0 0.0 0.0 0.0 3.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Degration | Organic Biosynthesis Xenobiotics | Aromatics | Amino acid Aromatic | Aromatics | Styrene Nitrile hydratase subunit alpha nthB 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Degration | Organic Biosynthesis Xenobiotics | Aromatics | Amino acid Aromatic | Aromatics | Styrene Nitrile hydratase subunit beta nudB 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Cofactor Vitamin B Dihydroneopterin triphosphate diphosphatase nudE 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Nucleotide Purine ADP compounds hydrolase nudF 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 Organic Biosynthesis Cofactor | Nucleotide Purine | Vitamin B ADP-ribose pyrophosphatas nuoA 2.0 2.0 2.0 2.0 2.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 1.0 2.0 1.0 1.0 1.0 2.0 1.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 1.0 0.0 Organic Degration Carbohydrate Oxidative phosphorylation NADH-quinone oxidoreductase subunit A nuoB 3.0 2.0 3.0 2.0 2.0 2.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 1.0 3.0 1.0 2.0 2.0 2.0 1.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 3.0 1.0 0.0 Organic Degration Carbohydrate Oxidative phosphorylation NADH-quinone oxidoreductase subunit B nuoC 1.0 2.0 2.0 2.0 4.0 1.0 0.0 1.0 2.0 1.0 2.0 3.0 0.0 1.0 1.0 2.0 3.0 1.0 1.0 1.0 2.0 1.0 0.0 0.0 0.0 1.0 2.0 1.0 0.0 1.0 2.0 1.0 0.0 Organic Degration Carbohydrate Oxidative phosphorylation NADH-quinone oxidoreductase nuoCD 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Degration Carbohydrate Oxidative phosphorylation NADH-quinone oxidoreductase subunit C/D nuoD 1.0 2.0 2.0 2.0 2.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 1.0 2.0 1.0 2.0 1.0 2.0 1.0 0.0 0.0 2.0 1.0 1.0 1.0 0.0 1.0 2.0 1.0 0.0 Organic Degration Carbohydrate Oxidative phosphorylation NADH-quinone oxidoreductase subunit D nuoE 1.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 2.0 1.0 0.0 0.0 1.0 0.0 0.0 2.0 1.0 0.0 1.0 1.0 0.0 Organic Transformation | Organic Degration Xenobiotics | Carbohydrate Lignin | Oxidative phosphorylation NADH-quinone oxidoreductase subunit E nuoF 3.0 1.0 1.0 1.0 1.0 3.0 1.0 2.0 2.0 1.0 1.0 1.0 1.0 0.0 2.0 2.0 1.0 1.0 1.0 1.0 4.0 1.0 0.0 1.0 1.0 1.0 1.0 3.0 1.0 0.0 3.0 1.0 0.0 Organic Transformation | Organic Degration Xenobiotics | Carbohydrate Lignin | Oxidative phosphorylation NADH-quinone oxidoreductase subunit F nuoG 1.0 1.0 1.0 0.0 1.0 1.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 Organic Transformation | Organic Degration Xenobiotics | Carbohydrate Lignin | Oxidative phosphorylation NADH-quinone oxidoreductase subunit G nuoH 3.0 2.0 2.0 2.0 2.0 1.0 0.0 1.0 1.0 2.0 1.0 1.0 0.0 1.0 2.0 1.0 2.0 1.0 2.0 0.0 2.0 2.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 Organic Degration Carbohydrate Oxidative phosphorylation NADH-quinone oxidoreductase subunit H nuoI 2.0 2.0 2.0 2.0 2.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 2.0 1.0 2.0 1.0 2.0 2.0 2.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 2.0 3.0 1.0 0.0 Organic Degration Carbohydrate Oxidative phosphorylation NADH-quinone oxidoreductase subunit I nuoJ 1.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 2.0 1.0 2.0 1.0 0.0 Organic Degration Carbohydrate Oxidative phosphorylation NADH-quinone oxidoreductase subunit J nuoK 2.0 2.0 2.0 2.0 2.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 2.0 1.0 1.0 2.0 1.0 2.0 1.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 1.0 0.0 Organic Degration Carbohydrate Oxidative phosphorylation NADH-quinone oxidoreductase subunit K nuoL 0.0 2.0 2.0 3.0 2.0 2.0 0.0 0.0 0.0 1.0 1.0 2.0 0.0 0.0 2.0 1.0 2.0 0.0 2.0 1.0 2.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 2.0 0.0 0.0 Organic Degration Carbohydrate Oxidative phosphorylation NADH-quinone oxidoreductase subunit L nuoM 3.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 2.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 1.0 0.0 Organic Degration Carbohydrate Oxidative phosphorylation NADH-quinone oxidoreductase subunit M nuoN 1.0 2.0 2.0 2.0 2.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 0.0 0.0 1.0 1.0 1.0 2.0 1.0 0.0 Organic Degration Carbohydrate Oxidative phosphorylation NADH-quinone oxidoreductase subunit N nxrA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 Transport | Carbon Fixation | Organic Degration Methane-anaerobic | Nitrogen cycle | CH4 | Two-component system Anaerobic oxidation of methane | Two-component system | Nitrification Nitrite oxidoreductase nxrB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 Organic Degration Nitrogen cycle Nitrification Nitrite oxidoreductase, beta subunit oadB 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Carbon Release | Organic Biosynthesis Carbohydrate | CO2 | Aromatics CO2 | Aromatics | Pyruvate Oxaloacetate decarboxylase oah 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 2.0 1.0 0.0 1.0 1.0 0.0 occM 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 Transport ABC transport ABC transport Octopine transport system permease protein occP 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 Transport ABC transport ABC transport Octopine ABC transporter ATP-binding protein|Octopine permease ATP-binding protein ocd 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Amino acid Cationic Ornithine cyclodeaminase oleB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Release CO2 CO2 Cis-3-alkyl-4-alkyloxetan-2-one decarboxylase oorB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Carbon Release | Organic Biosynthesis Carbohydrate | CO2 Citrate cycle | CO2 | Pyruvate | Glycolysis 2-Oxoglutarate:Ferredoxin oxidoreductase opd 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Organophosphorus compound Organic phosphoester hydrolysis Phosphotriesterase (organophosphorus-degrading genes) oppA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Transport ABC transport ABC transport Oligopeptide ABC transporter substrate-binding protein oppB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 Transport ABC transport ABC transport Oligopeptide transport system permease protein oppC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 Transport ABC transport ABC transport Oligopeptide transport system permease protein oppD 0.0 0.0 0.0 0.0 0.0 6.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Transport ABC transport ABC transport Oligopeptide transport ATP-binding protein oppF 1.0 0.0 0.0 0.0 0.0 8.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 Transport ABC transport ABC transport Oligopeptide transport ATP-binding protein ordL 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 2.0 0.0 0.0 0.0 Organic Biosynthesis Xenobiotics Others Oxidoreductase otnC 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Carbon Release CO2 CO2 3-oxo-tetronate 4-phosphate decarboxylase otr 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Inorganic sulfur transformation Sulfur reduction Octaheme tetrathionate reductase Otr otsA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Carbohydrate Polysaccharide Trehalose-6-phosphate synthase paaA 0.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 2.0 0.0 1.0 0.0 3.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 Organic Degration Xenobiotics | Aromatics Aromatics | Lignin 1,2-phenylacetyl-CoA epoxidase, subunit A paaB 0.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 2.0 0.0 1.0 0.0 3.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 Organic Degration Xenobiotics Lignin 1,2-phenylacetyl-CoA epoxidase, subunit B paaC 0.0 1.0 1.0 1.0 1.0 2.0 1.0 0.0 1.0 2.0 1.0 1.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 2.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 1.0 0.0 0.0 0.0 1.0 Organic Degration Xenobiotics Lignin 3-hydroxyacyl-CoA dehydrogenase paaD 0.0 2.0 2.0 1.0 2.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 1.0 0.0 1.0 1.0 0.0 2.0 Organic Degration Xenobiotics Lignin Phenylacetic acid degradation protein paaE1 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics Lignin 1,2-phenylacetyl-CoA epoxidase, subunit E paaE2 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics Lignin 3-oxoadipyl-CoA thiolase paaF 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Aromatics | Xenobiotics | CO2 | Lipid | Amino acid L-Amino acid | Aromatics | 3-Hydroxypropionate/4-Hydroxybutyrate Cycle | Fatty acid | Plastics | Lignin Enoyl-CoA hydratase paaH 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 Organic Degration Xenobiotics | Aromatics Aromatics | Lignin 3-hydroxybutyryl-CoA dehydrogenase paaI 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 Organic Degration Xenobiotics | Aromatics Aromatics | Lignin Acyl-coenzyme A thioesterase paaJ 1.0 1.0 2.0 2.0 2.0 2.0 1.0 0.0 1.0 3.0 2.0 4.0 2.0 3.0 2.0 0.0 2.0 0.0 2.0 1.0 1.0 2.0 1.0 0.0 0.0 1.0 0.0 3.0 3.0 1.0 1.0 1.0 1.0 Organic Degration Xenobiotics | Aromatics Aromatics | Lignin 3-oxo-5,6-didehydrosuberyl-CoA/3-oxoadipyl-CoA thiolase|3-oxoadipyl-CoA thiolase paaK 2.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics Lignin Phenylacetate-coenzyme A ligase paaN 0.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 Organic Degration Xenobiotics Lignin Bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase paaX 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics Lignin transcriptional repressor for phenylacetic acid degradation paaY 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 Organic Degration Xenobiotics Lignin Regulatory phaM protein paaZ 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 Organic Degration Xenobiotics | Aromatics Aromatics | Lignin 2-oxepin-2(3H)-ylideneacetyl-CoA hydrolase|3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase pac-K01434 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 pafA 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Organophosphorus compound Organic phosphoester hydrolysis Phosphoate-insensitive phosphomonoesterase panB 1.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 Organic Biosynthesis Cofactor Vitamin B 3-methyl-2-oxobutanoate hydroxymethyltransferase panC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Cofactor Vitamin B Pantoate--beta-alanine ligase panD 0.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 0.0 1.0 1.0 1.0 0.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 Carbon Release | Organic Biosynthesis CO2 | Amino acid | Cofactor CO2 | Anionic | beta-amino acid | Vitamin B Aspartate 1-decarboxylase patA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 patA-K09251 0.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Amino acid L-Amino acid Putrescine aminotransferase pbpA 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 2.0 1.0 1.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 2.0 1.0 1.0 0.0 1.0 0.0 Organic Transformation | Organic Biosynthesis Glycan Peptidoglycan Penicillin-binding protein|Peptidoglycan D,D-transpeptidase pbpB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Biosynthesis Glycan Peptidoglycan Penicillin-binding protein pbpC 0.0 1.0 0.0 1.0 1.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 Organic Transformation | Organic Biosynthesis Glycan Peptidoglycan Penicillin-binding protein|Probable peptidoglycan D,D-transpeptidase pbpG 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 Organic Transformation | Organic Biosynthesis Glycan Peptidoglycan D-alanyl-D-alanine endopeptidase|Penicillin-binding protein|Peptidoglycan transglycosylase pcaB 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Aromatics Aromatics | Lignin 3-carboxy-cis,cis-muconate cycloisomerase pcaC 0.0 0.0 0.0 0.0 0.0 4.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 2.0 0.0 1.0 0.0 Carbon Release | Organic Degration Xenobiotics | CO2 | Aromatics CO2 | Lignin | Aromatics 4-carboxymuconolactone decarboxylase pcaD 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Aromatics Aromatics | Lignin 3-oxoadipate enol-lactonase pcaF 0.0 1.0 1.0 1.0 1.0 3.0 2.0 0.0 1.0 8.0 1.0 4.0 1.0 1.0 1.0 0.0 2.0 0.0 1.0 2.0 1.0 1.0 1.0 0.0 0.0 1.0 0.0 2.0 7.0 2.0 1.0 2.0 2.0 Organic Degration Xenobiotics | Aromatics Aromatics | Lignin Beta-ketoadipyl-CoA thiolase pcaG 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Aromatics Aromatics | Lignin Protocatechuate 3,4-dioxygenase, alpha subunit pcaH 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Aromatics Aromatics | Lignin Protocatechuate 3,4-dioxygenase, beta subunit pcaI 0.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 2.0 1.0 0.0 1.0 0.0 1.0 1.0 2.0 2.0 2.0 0.0 0.0 2.0 0.0 0.0 0.0 2.0 0.0 3.0 1.0 Organic Degration Xenobiotics | Aromatics Aromatics | Lignin 3-oxoadipate CoA-transferase, subunit B pcaJ 0.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 2.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 2.0 0.0 3.0 1.0 Organic Degration Xenobiotics | Aromatics Aromatics | Lignin 3-oxoadipate CoA-transferase, subunit A pccA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Carbohydrate | CO2 | Lipid Pyruvate | 3-Hydroxypropionate Bicycle | 3-Hydroxypropionate/4-Hydroxybutyrate Cycle | Fatty acid Propionyl-CoA carboxylase pccB 0.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 1.0 Carbon Fixation CO2 3-Hydroxypropionate Bicycle | 3-Hydroxypropionate/4-Hydroxybutyrate Cycle Acetyl-CoA/propionyl-CoA carboxylase pchE 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 pchF-EC6.2.1.69 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Lipid Polyketide Pyochelin synthetase pckA 0.0 1.0 1.0 1.0 1.0 2.0 0.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 1.0 1.0 0.0 0.0 1.0 Organic Degration | Carbon Release | Organic Biosynthesis Organophosphorus compound | CO2 | Photosynthesis | Carbohydrate Glycolysis | CO2 | C4 cycle | Pyruvate metabolism Phosphoenolpyruvate carboxykinase (ATP) pckG 0.0 0.0 1.0 1.0 0.0 0.0 1.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 0.0 0.0 0.0 1.0 0.0 Organic Degration | Organic Biosynthesis Carbohydrate | Organophosphorus compound Pyruvate | Pyruvate metabolism Phosphoenolpyruvate carboxykinase (GTP) pcs 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration Lipid Fatty acid Phosphatidylcholine synthase pct 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Xenobiotics | Carbohydrate Styrene | Pyruvate Propionate CoA-transferase pdc 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Release | Organic Transformation | Organic Degration Xenobiotics | Carbohydrate | CO2 Lignin | CO2 | Fermentation | Glycolysis Pyruvate decarboxylase pdhA 0.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Carbon Release | Organic Biosynthesis Carbohydrate | CO2 Monosaccharide | CO2 | Pyruvate Pyruvate dehydrogenase E1 component subunit alpha pdhC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Carbohydrate Fermentation | Pyruvate Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex pduL 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 pduO 0.0 1.0 1.0 1.0 1.0 3.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 Organic Biosynthesis Cofactor Vitamin B | Porphyrin Corrinoid adenosyltransferase pdx1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B Pyridoxal 5'-phosphate synthase pdxA 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 0.0 2.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 Carbon Release | Organic Biosynthesis CO2 | Cofactor CO2 | Vitamin B 4-hydroxythreonine-4-phosphate dehydrogenase pdxA2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 Carbon Release CO2 CO2 4-phospho-D-threonate 3-dehydrogenase|4-phospho-D-erythronate 3-dehydrogenase pdxB 0.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B Erythronate-4-phosphate dehydrogenase pdxJ 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 Organic Biosynthesis Cofactor Vitamin B Pyridoxine 5'-phosphate synthase pdxT 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B Pyridoxal 5'-phosphate synthase pel 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Carbohydrate Monosaccharide | Pectin Pectate lyase penA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Glycan Peptidoglycan Peptidoglycan D,D-transpeptidase pep2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Carbohydrate Polysaccharide Maltokinase pepA 1.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 1.0 0.0 3.0 1.0 0.0 1.0 0.0 0.0 1.0 1.0 0.0 1.0 2.0 1.0 0.0 0.0 1.0 0.0 0.0 1.0 3.0 1.0 1.0 0.0 pepD 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 pepM 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 Organic Degration | Organic Biosynthesis Organophosphorus compound | Secondary metabolite | Antibiotic Secondary metabolite | Phosphonate and phosphinate metabolism | Antibiotic Phosphoenolpyruvate phosphomutase petA-K00411 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 2.0 1.0 1.0 0.0 1.0 0.0 Organic Degration Carbohydrate Oxidative phosphorylation Quinol-cytochrome-c reductase petB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Degration | Transport | Organic Biosynthesis Carbohydrate | Photosynthesis | Two-component system Two-component system | Photosynthetic pigment | Oxidative phosphorylation Ubiquinol-cytochrome c reductase petC-K00413 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 Organic Degration Carbohydrate Oxidative phosphorylation Ubiquinol--cytochrome c reductase|Cytochrome c1 petH 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Fixation Photosynthesis Photosynthetic electron transport Ferredoxin--NADP reductase pfkA 1.0 1.0 1.0 0.0 1.0 1.0 2.0 1.0 1.0 1.0 1.0 0.0 1.0 2.0 1.0 3.0 1.0 0.0 1.0 2.0 0.0 1.0 3.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Carbohydrate | CH4 | Methane-aerobic Aerobic oxidation | Pentose phosphate | Monosaccharide | Glycolysis | RuMP pathway 6-phosphofructokinase pfkB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Carbohydrate | CH4 | Methane-aerobic Aerobic oxidation | Pentose phosphate | Monosaccharide | Glycolysis | RuMP pathway 6-phosphofructokinase pfp 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 0.0 0.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Carbohydrate | CH4 | Methane-aerobic Aerobic oxidation | Pentose phosphate | Monosaccharide | Glycolysis | RuMP pathway Pyrophosphate--fructose 6-phosphate 1-phosphotransferase pgi 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 2.0 0.0 1.0 0.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 Organic Degration | Organic Biosynthesis Carbohydrate | Photosynthesis Monosaccharide | Pentose phosphate | Calvin cycle | Glycolysis Glucose-6-phosphate isomerase pgk 1.0 1.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 1.0 0.0 1.0 2.0 1.0 2.0 1.0 1.0 1.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Carbohydrate | CO2 | Photosynthesis Calvin cycle | Calvin-Benson-Bassham Cycle | Glycolysis Phosphoglycerate kinase pgm 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Carbohydrate | Secondary metabolite | Antibiotic | Nucleotide Pentose phosphate | Antibiotic | Monosaccharide | Purine | Glycolysis | Secondary metabolite Phosphoglucomutase pgpA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 Organic Degration Lipid Fatty acid Phosphatidylglycerophosphatase A pgsA 0.0 0.0 0.0 0.0 0.0 1.0 0.0 2.0 0.0 2.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 2.0 1.0 2.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 1.0 2.0 1.0 0.0 Organic Degration Lipid Fatty acid CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase pgtC 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport | Organic Biosynthesis Organophosphorus compound | Two-component system Two-component system Phosphoglycerate transport regulatory protein PgtC phaB 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 1.0 0.0 1.0 0.0 Organic Degration Xenobiotics Lignin Enoyl-CoA hydratase/isomerase phbB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 phbC 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 phbC-EC2.3.1 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.0 0.0 2.0 0.0 1.0 0.0 Organic Transformation | Organic Degration Glycan | Carbohydrate Peptidoglycan | Polysaccharide Poly-beta-hydroxybutyrate polymerase phcHL 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics Lignin Hydroxycinnamoyl-CoA hydratase-lyase phcS 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics Lignin p-hydroxycinnamoyl-CoA synthetase pheA 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 0.0 3.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 1.0 1.0 0.0 Carbon Release CO2 CO2 Chorismate mutase|Prephenate dehydratase pheA2 0.0 1.0 1.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 Carbon Release CO2 CO2 Prephenate dehydratase phhA 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Xenobiotics | Amino acid | Cofactor Aromatic | Aliphatic | Lignin | Vitamin B Phenylalanine-4-hydroxylase phhB 0.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 Organic Degration | Organic Biosynthesis Xenobiotics | Cofactor Lignin | Vitamin B Pterin-4-alpha-carbinolamine dehydratase phlN 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics Lignin Putative hydroxylase component phnA 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Xenobiotics | Organophosphorus compound Organic pollutant | Phosphonate and phosphinate metabolism Phosphonoacetate hydrolase phnC 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 0.0 0.0 0.0 Transport | Organic Biosynthesis Organophosphorus compound | ABC transport Transmembrane transport | ABC transport Phosphonates import ATP-binding protein phnD 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport | Organic Biosynthesis Organophosphorus compound | ABC transport Transmembrane transport | ABC transport ABC transporter phosphite binding protein phnD_phosphite 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Inorganic phosphorus Transmembrane transport probable ABC transporter phosphite binding protein phnE 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 Transport | Organic Biosynthesis Organophosphorus compound | Phosphotransferase system | ABC transport Transmembrane transport | Phosphotransferase system | ABC transport Phosphonate transport system permease protein phnF 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Biosynthesis Inorganic phosphorus Auxiliary GntR family transcriptional regulator, phosphonate transport system regulatory protein phnL 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Organophosphorus compound Phosphonate and phosphinate metabolism Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnL phnM 1.0 1.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 1.0 0.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 3.0 1.0 1.0 1.0 Organic Biosynthesis Organophosphorus compound Phosphonate and phosphinate metabolism Alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase phnN 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Organophosphorus compound | Carbohydrate Monosaccharide | Pentose phosphate | Phosphonate and phosphinate metabolism Ribose 1,5-bisphosphate phosphokinase phnP 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Organophosphorus compound Phosphonate and phosphinate metabolism Phosphoribosyl 1,2-cyclic phosphate phosphodiesterase phnPP 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Organophosphorus compound Phosphonate and phosphinate metabolism Phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase phnS 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport | Organic Biosynthesis Organophosphorus compound | Phosphotransferase system | ABC transport Transmembrane transport | Phosphotransferase system | ABC transport 2-aminoethylphosphonate-binding periplasmic protein phnW 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 Organic Biosynthesis Organophosphorus compound Phosphonate and phosphinate metabolism 2-aminoethylphosphonate--pyruvate transaminase phnX 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Xenobiotics | Organophosphorus compound Organic pollutant | Phosphonate and phosphinate metabolism Phosphonoacetaldehyde hydrolase phnZ 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Organophosphorus compound Phosphonate and phosphinate metabolism 2-amino-1-hydroxyethylphosphonate dioxygenase phny 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Organophosphorus compound Phosphonate and phosphinate metabolism Phosphonoacetaldehyde dehydrogenase phoA 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 Organic Degration | Transport | Organic Biosynthesis Organophosphorus compound | Two-component system | Cofactor Organic phosphoester hydrolysis | Two-component system | Vitamin B Alkaline phosphatase phoB 2.0 5.0 2.0 4.0 3.0 10.0 2.0 4.0 3.0 4.0 3.0 3.0 4.0 5.0 2.0 4.0 1.0 1.0 2.0 3.0 3.0 3.0 4.0 1.0 0.0 2.0 3.0 10.0 5.0 9.0 5.0 6.0 1.0 Organic Degration | Transport | Organic Biosynthesis Two-component system | Inorganic phosphorus | Cofactor Two-component system | Vitamin B Alkaline phosphatase phoD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Degration | Transport | Organic Biosynthesis Organophosphorus compound | Two-component system | Cofactor Organic phosphoester hydrolysis | Two-component system | Vitamin B Alkaline phosphatase D phoH 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 Organic Biosynthesis Inorganic phosphorus Auxiliary Phosphate starvation-inducible protein PhoH and related proteins phoN 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Degration | Transport | Organic Biosynthesis Organophosphorus compound | Two-component system | Cofactor Organic phosphoester hydrolysis | Two-component system | Vitamin B Acid phosphatase phoP 1.0 4.0 2.0 3.0 3.0 5.0 2.0 0.0 2.0 8.0 3.0 1.0 3.0 3.0 2.0 1.0 1.0 1.0 3.0 7.0 1.0 3.0 1.0 1.0 0.0 1.0 1.0 11.0 4.0 3.0 4.0 4.0 2.0 Transport | Organic Biosynthesis Two-component system | Inorganic phosphorus Two-component system PhoP|two-component system, OmpR family, alkaline phosphatase synthesis response regulator PhoP phoR 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 1.0 1.0 0.0 Transport | Organic Biosynthesis Two-component system | Inorganic phosphorus Two-component system Two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR phoU 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 1.0 0.0 Transport | Organic Biosynthesis Two-component system | Inorganic phosphorus Two-component system phoR/phoB inhibitor protein phoU phoX 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Organophosphorus compound Organic phosphoester hydrolysis Alkaline phosphatase phsC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Inorganic sulfur transformation Sulfur disproportionation Thiosulfate reductase electron transfer pht3 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Aromatics Aromatics | Lignin Phthalate 4,5-dioxygenase oxygenase subunit pht5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Carbon Release | Organic Degration CO2 | Aromatics CO2 | Aromatics 4,5-dihydroxyphthalate decarboxylase phzF 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 pikC 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Biosynthesis Lipid Polyketide Cytochrome P450 monooxygenase pimA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Biosynthesis Glycan Glycolipid Phosphatidyl-myo-inositol mannosyltransferase pimC 0.0 0.0 0.0 0.0 0.0 3.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Transformation | Organic Biosynthesis Xenobiotics | Glycan | Carbohydrate Glycolipid | Lignin Pimeloyl-CoA dehydrogenase large subunit pimE 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Transformation | Organic Biosynthesis Xenobiotics | Glycan | Carbohydrate Glycolipid | Lignin Polyprenol-phosphate-mannose-dependent alpha-(1-2)-phosphatidylinositol pentamannoside mannosyltransferase pip 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Amino acid Aliphatic | Cationic Proline iminopeptidase pirA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport Two-component system Two-component system Phosphoribosyl isomerase A pit 0.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 2.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 2.0 0.0 1.0 Organic Biosynthesis Inorganic phosphorus Transmembrane transport inorganic phosphate transporter plsB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Biosynthesis Lipid Fatty acid Glycerol-3-phosphate acyltransferase plsX 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 0.0 1.0 2.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 Organic Degration Lipid Fatty acid Phosphate acyltransferase plsY 1.0 0.0 1.0 1.0 1.0 2.0 0.0 1.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 Organic Degration | Organic Transformation | Organic Biosynthesis Lipid Fatty acid Glycerol-3-phosphate acyltransferase pncA 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 Organic Degration Cofactor Vitamin B Nicotinamidase pntA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Cofactor Vitamin B NAD(P) transhydrogenase subunit alpha pntB 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 2.0 1.0 1.0 1.0 0.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 2.0 0.0 Organic Degration | Organic Biosynthesis Cofactor Vitamin B NAD(P) transhydrogenase pobA 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics | Aromatics Aromatics | Lignin p-hydroxybenzoate hydroxylase porA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 Organic Degration | Carbon Fixation | Carbon Release | Organic Biosynthesis Aromatics | Methane-aerobic | CH4 | Carbohydrate | CO2 Citrate cycle | Aromatics | Aerobic oxidation | Fermentation | Dicarboxylate/4-hydroxybutyrate cycle | serine cycle | CO2 | Pyruvate Pyruvate ferredoxin oxidoreductase porB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.0 0.0 0.0 Organic Degration | Carbon Fixation | Carbon Release | Organic Biosynthesis Aromatics | Methane-aerobic | CH4 | Carbohydrate | CO2 Citrate cycle | Aromatics | Aerobic oxidation | Dicarboxylate/4-hydroxybutyrate cycle | serine cycle | CO2 | Pyruvate Pyruvate ferredoxin oxidoreductase porC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Carbon Fixation | Carbon Release | Organic Biosynthesis Carbohydrate | CO2 | Aromatics Citrate cycle | Aromatics | Dicarboxylate/4-hydroxybutyrate cycle | CO2 | Pyruvate Pyruvate ferredoxin oxidoreductase porD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 Organic Degration | Carbon Fixation | Carbon Release | Organic Biosynthesis Aromatics | Methane-aerobic | CH4 | Carbohydrate | CO2 Citrate cycle | Aromatics | Aerobic oxidation | Dicarboxylate/4-hydroxybutyrate cycle | serine cycle | CO2 | Pyruvate Pyruvate ferredoxin oxidoreductase porG 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 Organic Degration | Carbon Fixation | Carbon Release | Organic Biosynthesis Aromatics | Methane-aerobic | CH4 | Carbohydrate | CO2 Citrate cycle | Aromatics | Aerobic oxidation | Dicarboxylate/4-hydroxybutyrate cycle | serine cycle | CO2 | Pyruvate Pyruvate ferredoxin oxidoreductase potA 0.0 0.0 0.0 0.0 0.0 8.0 0.0 2.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 1.0 2.0 1.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 2.0 0.0 1.0 0.0 Transport ABC transport ABC transport Spermidine/putrescine import ATP-binding protein potB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 Transport ABC transport ABC transport Spermidine/putrescine transport system permease protein potF 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 Transport ABC transport ABC transport Putrescine-binding periplasmic protein potH 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 Transport ABC transport ABC transport Putrescine transport system permease protein potI 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport ABC transport ABC transport Putrescine transport system permease protein poxB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Degration | Carbon Release | Organic Transformation | Organic Biosynthesis Xenobiotics | Carbohydrate | CO2 | Aromatics Organic pollutant | Aromatics | CO2 | Lignin | Pyruvate Pyruvate dehydrogenase/oxidase poxE 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Aromatics Organic pollutant | Aromatics Phenol hydroxylase poxF 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Aromatics Organic pollutant | Aromatics Phenol hydroxylase ppa 0.0 2.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 2.0 1.0 1.0 0.0 1.0 0.0 0.0 1.0 0.0 1.0 1.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 1.0 1.0 0.0 1.0 1.0 0.0 Organic Degration | Organic Biosynthesis Carbohydrate | Inorganic phosphorus Oxidative phosphorylation Inorganic pyrophosphatase ppaC 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration Carbohydrate Oxidative phosphorylation Manganese-dependent inorganic pyrophosphatase ppc 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 Organic Degration | Carbon Fixation | Carbon Release | Organic Biosynthesis Photosynthesis | Methane-aerobic | Organophosphorus compound | CH4 | Carbohydrate | CO2 Aerobic oxidation | Fermentation | Dicarboxylate/4-hydroxybutyrate cycle | serine cycle | C4 cycle | CO2 | Pyruvate | Pyruvate metabolism Phosphoenolpyruvate carboxylase ppd 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 1.0 0.0 Organic Biosynthesis Organophosphorus compound Phosphonate and phosphinate metabolism Phosphonopyruvate decarboxylase ppdK 0.0 0.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 0.0 0.0 0.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Carbohydrate | CO2 | Organophosphorus compound Glycolysis | Pyruvate | Dicarboxylate/4-hydroxybutyrate cycle | Pyruvate metabolism Pyruvate, phosphate dikinase ppk 0.0 2.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 2.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 2.0 1.0 1.0 1.0 1.0 0.0 Organic Degration | Organic Biosynthesis Carbohydrate | Inorganic phosphorus Oxidative phosphorylation Polyphosphate kinase ppk2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Carbohydrate Oxidative phosphorylation Polyphosphate kinase ppnN 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Nucleotide Purine | Pyrimidine Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase ppnP 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Nucleotide Purine | Pyrimidine Pyrimidine/purine nucleoside phosphorylase pps 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 2.0 1.0 0.0 0.0 0.0 1.0 2.0 0.0 0.0 1.0 1.0 1.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Methane-aerobic | Cofactor | Organophosphorus compound | CH4 | Carbohydrate | CO2 Aerobic oxidation | Dicarboxylate/4-hydroxybutyrate cycle | serine cycle | Glycolysis | Coenzyme | Pyruvate | Pyruvate metabolism Pyruvate, water dikinase ppsA 1.0 1.0 1.0 2.0 1.0 1.0 1.0 0.0 2.0 2.0 0.0 0.0 0.0 2.0 2.0 0.0 1.0 0.0 1.0 0.0 2.0 2.0 2.0 0.0 1.0 0.0 1.0 2.0 1.0 1.0 2.0 2.0 1.0 Organic Degration | Carbon Fixation | Organic Transformation | Organic Biosynthesis Xenobiotics | Carbohydrate | CO2 Lignin | Pyruvate | Dicarboxylate/4-hydroxybutyrate cycle | Glycolysis Pyruvate, water dikinase ppx 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 Organic Degration | Organic Biosynthesis Organophosphorus compound | Nucleotide Purine | Purine metabolism Exopolyphosphatase|Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase pqqB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 Carbon Fixation | Organic Degration CH4 | Methane-aerobic Oxidation of merthane and C1 compounds | Aerobic oxidation Coenzyme PQQ synthesis pqqC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 Carbon Fixation | Organic Degration CH4 | Methane-aerobic Oxidation of merthane and C1 compounds | Aerobic oxidation Coenzyme PQQ synthesis pqqD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 Carbon Fixation | Organic Degration CH4 | Methane-aerobic Oxidation of merthane and C1 compounds | Aerobic oxidation Coenzyme PQQ synthesis pqqE 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 Carbon Fixation | Organic Degration CH4 | Methane-aerobic Oxidation of merthane and C1 compounds | Aerobic oxidation Coenzyme PQQ synthesis pqqF 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 Carbon Fixation | Organic Degration CH4 | Methane-aerobic Oxidation of merthane and C1 compounds | Aerobic oxidation Coenzyme PQQ synthesis priA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Amino acid Aromatic | Cationic Phosphoribosyl isomerase prkB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 Carbon Fixation | Organic Biosynthesis CO2 | Photosynthesis Calvin cycle | Calvin-Benson-Bassham Cycle Phosphoribulokinase prmA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 prmB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 proA-gamma 1.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 2.0 0.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 2.0 1.0 0.0 Organic Biosynthesis Amino acid Aliphatic Gamma-glutamyl phosphate reductase proB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Amino acid Aliphatic | Anionic Glutamate 5-kinase proC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Amino acid Aliphatic Pyrroline-5-carboxylate reductase proV 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Transport ABC transport ABC transport Glycine betaine/proline betaine transport system ATP-binding protein proX 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Transport ABC transport ABC transport Glycine betaine/proline transport system substrate-binding protein prpB 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 prpC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 prpD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 prpE 2.0 1.0 2.0 1.0 1.0 2.0 2.0 1.0 2.0 2.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 1.0 0.0 1.0 2.0 1.0 2.0 1.0 1.0 1.0 Organic Degration Organic sulfur cycle | DMSP catabolic pathway Ancillary genes | Organic sulfur transformation Propionate--CoA ligase prpF 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 prr 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Amino acid beta-amino acid | Cationic Gamma-aminobutyraldehyde dehydrogenase prsA 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 2.0 1.0 1.0 0.0 1.0 1.0 2.0 1.0 1.0 2.0 2.0 1.0 Organic Degration | Organic Biosynthesis Organophosphorus compound | Nucleotide | Carbohydrate Monosaccharide | Purine | Pentose phosphate pathway | Pentose phosphate Ribose-phosphate pyrophosphokinase psd 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 Carbon Release | Organic Transformation | Organic Biosynthesis CO2 | Lipid CO2 | Fatty acid Phosphatidylserine decarboxylase pseB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Glycan O-linked UDP-N-acetylglucosamine 4,6-dehydratase pssA 0.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 1.0 0.0 Organic Transformation | Organic Biosynthesis Lipid Fatty acid CDP-diacylglycerol--serine O-phosphatidyltransferase pstA 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 Transport | Organic Biosynthesis Inorganic phosphorus | Phosphotransferase system | ABC transport Transmembrane transport | Phosphotransferase system | ABC transport Phosphate transport system permease protein pstB 1.0 0.0 0.0 0.0 0.0 1.0 0.0 2.0 1.0 1.0 0.0 1.0 1.0 0.0 1.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 2.0 5.0 1.0 1.0 0.0 1.0 1.0 0.0 Transport | Organic Biosynthesis Inorganic phosphorus | Phosphotransferase system | ABC transport Transmembrane transport | Phosphotransferase system | ABC transport Phosphate import ATP-binding protein pstC 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 Transport | Organic Biosynthesis Inorganic phosphorus | Phosphotransferase system | ABC transport Transmembrane transport | Phosphotransferase system | ABC transport Phosphate transport system permease protein PstC pstS 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 2.0 0.0 0.0 1.0 0.0 1.0 2.0 0.0 1.0 1.0 0.0 2.0 1.0 0.0 1.0 0.0 0.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 Transport | Organic Biosynthesis Inorganic phosphorus | Phosphotransferase system | ABC transport Transmembrane transport | Phosphotransferase system | ABC transport Phosphate transport system pta 1.0 2.0 2.0 1.0 1.0 4.0 1.0 0.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 2.0 1.0 0.0 0.0 0.0 3.0 3.0 1.0 0.0 1.0 0.0 Organic Degration | Carbon Release | Organic Biosynthesis Organic sulfur cycle | Carbohydrate | CH4 Organic sulfur transformation | Aceticlastic methanogenesis | Fermentation | Pyruvate Phosphate acetyltransferase ptlE 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 ptsG 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport | Organic Degration Carbohydrate | Phosphotransferase system | Transport system Transport system | Phosphotransferase system | Glycolysis PTS system glucose-specific EIICBA component ptsH 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 2.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 Transport | Organic Biosynthesis Organophosphorus compound | Phosphotransferase system Phosphotransferase system Phosphocarrier protein ptsI 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 Transport | Organic Biosynthesis Organophosphorus compound | Phosphotransferase system Phosphotransferase system Phosphoenolpyruvate-protein phosphotransferase ptsN 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 Transport Phosphotransferase system Phosphotransferase system Phosphotransferase enzyme IIA component pulA 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Carbohydrate Starch | Hemicellulose Pullulanase purA 1.0 2.0 1.0 2.0 3.0 1.0 1.0 1.0 2.0 1.0 3.0 2.0 2.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Organic Degration | Organic Biosynthesis Organophosphorus compound | Nucleotide Purine | Purine metabolism Adenylosuccinate synthetase purB 1.0 1.0 0.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 2.0 1.0 Organic Degration | Organic Biosynthesis Organophosphorus compound | Nucleotide Purine | Purine metabolism Adenylosuccinate lyase purC 1.0 1.0 1.0 1.0 1.0 2.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Organic Degration | Organic Biosynthesis Organophosphorus compound | Nucleotide Purine | Purine metabolism Phosphoribosylaminoimidazole-succinocarboxamide synthase purD 2.0 1.0 2.0 1.0 3.0 1.0 1.0 1.0 1.0 2.0 2.0 2.0 1.0 1.0 1.0 2.0 2.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 1.0 1.0 1.0 2.0 1.0 1.0 Organic Degration | Organic Biosynthesis Organophosphorus compound | Nucleotide Purine | Purine metabolism phosphoribosylamine---glycine ligase purE 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Organic Degration | Organic Biosynthesis Organophosphorus compound | Nucleotide Purine | Purine metabolism 5-(carboxyamino)imidazole ribonucleotide mutase purF 1.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 1.0 Organic Degration | Organic Biosynthesis Organophosphorus compound | Nucleotide Purine | Purine metabolism Amidophosphoribosyltransferase purH 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 2.0 1.0 2.0 1.0 2.0 1.0 Organic Degration | Organic Biosynthesis Organophosphorus compound | Cofactor | Nucleotide Purine | Vitamin B | Purine metabolism Phosphoribosylaminoimidazolecarboxamide formyltransferase|Inosine 5'-monophosphate cyclohydrolase purK 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 Organic Biosynthesis Organophosphorus compound | Nucleotide Purine | Purine metabolism 5-carboxyaminoimidazole ribonucleotide synthase purL 1.0 1.0 1.0 0.0 1.0 2.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Organic Biosynthesis Organophosphorus compound | Nucleotide Purine | Purine metabolism Phosphoribosylformylglycinamidine synthase purM 1.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 Organic Biosynthesis Organophosphorus compound | Nucleotide Purine | Purine metabolism Phosphoribosylformylglycinamidine cyclo-ligase purN 1.0 1.0 1.0 2.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 2.0 1.0 1.0 1.0 2.0 1.0 Organic Degration | Organic Biosynthesis Organophosphorus compound | Cofactor | Nucleotide Purine | Vitamin B | Purine metabolism phosphoribosylglycinamide formyltransferase 1 purQ 0.0 1.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 1.0 0.0 1.0 Organic Degration | Organic Biosynthesis Organophosphorus compound | Amino acid | Nucleotide Purine metabolism | Purine | Cationic | D-Amino acid Phosphoribosylformylglycinamidine synthase purS 0.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 2.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 Organic Degration | Organic Biosynthesis Organophosphorus compound | Nucleotide Purine | Purine metabolism Phosphoribosylformylglycinamidine synthase subunit PurS purT 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 1.0 0.0 Organic Degration | Organic Biosynthesis Organophosphorus compound | Nucleotide Purine | Purine metabolism phosphoribosylglycinamide formyltransferase 2 putA 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 1.0 0.0 0.0 puuB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Amino acid Cationic Gamma-glutamylputrescine oxidoreductase puuC 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 puuE 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Amino acid beta-amino acid 4-aminobutyrate aminotransferase pyc 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Carbohydrate Citrate cycle | Pyruvate Pyruvate carboxylase pycA 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Carbohydrate | Photosynthesis C4 cycle | Citrate cycle | Pyruvate pyruvate carboxylase subunit A pycB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 0.0 0.0 Organic Degration | Organic Biosynthesis Carbohydrate | Photosynthesis C4 cycle | Citrate cycle | Pyruvate Pyruvate carboxylase subunit B pyk 3.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 1.0 2.0 1.0 0.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 3.0 2.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 0.0 1.0 Organic Degration | Organic Biosynthesis Carbohydrate | Nucleotide | Organophosphorus compound Purine | Glycolysis | Pyruvate | Pyruvate metabolism Pyruvate kinase pyrB 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 1.0 Organic Biosynthesis Amino acid | Nucleotide Pyrimidine | Anionic Aspartate carbamoyltransferase pyrC 1.0 1.0 1.0 2.0 2.0 3.0 1.0 1.0 1.0 1.0 1.0 3.0 0.0 1.0 1.0 2.0 1.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 0.0 1.0 1.0 4.0 1.0 2.0 1.0 1.0 0.0 Organic Biosynthesis Nucleotide Pyrimidine Dihydroorotas pyrD 1.0 2.0 1.0 2.0 2.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 Organic Biosynthesis Nucleotide Pyrimidine Dihydroorotate dehydrogenase pyrE 0.0 1.0 1.0 2.0 1.0 1.0 1.0 0.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Organic Degration | Organic Biosynthesis Organophosphorus compound | Nucleotide Pyrimidine | Pyrimidine metabolism Orotate phosphoribosyltransferase pyrF 0.0 2.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 0.0 1.0 1.0 1.0 1.0 3.0 1.0 1.0 1.0 1.0 1.0 2.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 Organic Degration | Carbon Release | Organic Biosynthesis Organophosphorus compound | CO2 | Nucleotide CO2 | Pyrimidine | Pyrimidine metabolism Orotidine 5'-phosphate decarboxylase pyrG 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 1.0 Organic Degration | Organic Biosynthesis Organophosphorus compound | Nucleotide Pyrimidine | Pyrimidine metabolism CTP synthase pyrH 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Organic Degration | Organic Biosynthesis Organophosphorus compound | Nucleotide Pyrimidine | Pyrimidine metabolism Uridylate kinase qcrA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Carbohydrate Oxidative phosphorylation Cytochrome bc1 complex Rieske iron-sulfur subunit qdtB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Glycan O-linked UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase qmoA 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Inorganic sulfur transformation Dissimilatory sulfur reduction and oxidation Quinone-modifying oxidoreductase, subunit QmoA qoxA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Carbohydrate Oxidative phosphorylation Quinol oxidase qoxC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Carbohydrate Oxidative phosphorylation Quinol oxidase queC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Cofactor Vitamin B 7-cyano-7-deazaguanine synthase queD 1.0 2.0 2.0 2.0 2.0 0.0 2.0 0.0 2.0 0.0 1.0 0.0 1.0 2.0 1.0 1.0 1.0 1.0 2.0 0.0 1.0 1.0 2.0 1.0 0.0 1.0 0.0 2.0 1.0 0.0 1.0 1.0 0.0 Organic Degration Cofactor Vitamin B 6-pyruvoyl tetrahydrobiopterin synthase|6-carboxy-5,6,7,8-tetrahydropterin synthase rbcS 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Fixation | Carbon Release | Organic Biosynthesis CO2 | Photosynthesis CO2 | Calvin cycle | Calvin-Benson-Bassham Cycle Ribulose bisphosphate carboxylase rbsA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 4.0 0.0 0.0 0.0 Transport ABC transport ABC transport Ribose import ATP-binding protein rbsC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 Transport ABC transport ABC transport Ribose import permease protein rbtD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration Carbohydrate Monosaccharide Ribitol 2-dehydrogenase rdgB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Degration Nucleotide Purine dITP/XTP pyrophosphatase rfaC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Transformation | Organic Biosynthesis Glycan Lipopolysaccharide Lipopolysaccharide heptosyltransferase rfaD 0.0 2.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 Organic Transformation | Organic Biosynthesis Glycan Lipopolysaccharide ADP-L-glycero-D-manno-heptose-6-epimerase rfaE 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 Organic Transformation | Organic Biosynthesis Glycan Lipopolysaccharide D-beta-D-heptose 7-phosphate kinase|D-beta-D-heptose 1-phosphate adenylyltransferase rfaE1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 Organic Transformation | Organic Biosynthesis Glycan Lipopolysaccharide D-beta-D-heptose 7-phosphate kinase rfaE2 1.0 2.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 Organic Transformation | Organic Biosynthesis Glycan Lipopolysaccharide D-beta-D-heptose 1-phosphate adenylyltransferase rfaP 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Biosynthesis Glycan Lipopolysaccharide Lipopolysaccharide core heptose(I) kinase rfbA 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 Organic Degration | Transport | Organic Biosynthesis Glycan | Carbohydrate | ABC transport Monosaccharide | O-linked | ABC transport | Lipopolysaccharide Glucose-1-phosphate thymidylyltransferase|O-antigen export system permease protein|Mannose-1-phosphate guanylyltransferase rfbB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 Organic Biosynthesis Glycan | Secondary metabolite | Antibiotic Glycopeptide | Vancomycin | O-linked dTDP-glucose 4,6-dehydratase rfbC 0.0 0.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Glycan O-linked | Lipopolysaccharide dTDP-4-dehydrorhamnose 3,5-epimerase rfbD 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 Organic Biosynthesis Glycan O-linked | Lipopolysaccharide dTDP-4-dehydrorhamnose reductase rfbH 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Glycan O-linked Lipopolysaccharide biosynthesis protein rffG 0.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 Organic Biosynthesis Glycan | Carbohydrate | Secondary metabolite | Antibiotic Glycopeptide | Oligosaccharide | Vancomycin | O-linked dTDP-glucose 4,6-dehydratase rffH 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Glycan | Carbohydrate Oligosaccharide | O-linked Glucose-1-phosphate thymidylyltransferase rhaA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Degration Carbohydrate Monosaccharide L-rhamnose isomerase ribA 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 0.0 Organic Degration | Organic Biosynthesis Cofactor Vitamin B GTP cyclohydrolase-2 ribB 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 0.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 1.0 Organic Biosynthesis Cofactor Vitamin B 3,4-dihydroxy-2-butanone 4-phosphate synthase ribBA 1.0 0.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 1.0 0.0 1.0 Organic Degration | Organic Biosynthesis Cofactor Vitamin B Riboflavin biosynthesis protein ribD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B Riboflavin biosynthesis protein ribD1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B Diaminohydroxyphosphoribosylamino-pyrimidine deaminase ribE 0.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 2.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 Organic Biosynthesis Cofactor Vitamin B Riboflavin synthase ribF 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 2.0 1.0 1.0 1.0 0.0 Organic Biosynthesis Cofactor Vitamin B Riboflavin kinase|FMN adenylyltransferase ribH 1.0 0.0 1.0 0.0 1.0 2.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Organic Biosynthesis Cofactor Vitamin B 6,7-dimethyl-8-ribityllumazine synthase rmlA 1.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Organic Biosynthesis Glycan | Carbohydrate Oligosaccharide | O-linked Glucose-1-phosphate thymidylyltransferase rmlB 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 2.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 Organic Biosynthesis Glycan | Carbohydrate | Secondary metabolite | Antibiotic Glycopeptide | Oligosaccharide | Vancomycin | O-linked dTDP-glucose 4,6-dehydratase rmlC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Glycan O-linked dTDP-4-dehydrorhamnose 3,5-epimerase rmlD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Glycan O-linked dTDP-4-dehydrorhamnose reductase rnfA 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 2.0 1.0 0.0 0.0 0.0 0.0 Carbon Fixation | Carbon Release | Organic Degration Methane-anaerobic | CH4 Anaerobic oxidation of methane | Central methanogenic pathway Na+-translocating ferredoxin:NAD+ oxidoreductase rnfB 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 4.0 1.0 0.0 0.0 1.0 0.0 Carbon Fixation | Carbon Release | Organic Degration Methane-anaerobic | CH4 Anaerobic oxidation of methane | Central methanogenic pathway Na+-translocating ferredoxin:NAD+ oxidoreductase rnfC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 3.0 1.0 0.0 0.0 0.0 0.0 Carbon Fixation | Carbon Release | Organic Degration Methane-anaerobic | CH4 Anaerobic oxidation of methane | Central methanogenic pathway Na+-translocating ferredoxin:NAD+ oxidoreductase rnfD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 2.0 1.0 0.0 0.0 0.0 2.0 1.0 0.0 0.0 0.0 1.0 Carbon Fixation | Carbon Release | Organic Degration Methane-anaerobic | CH4 Anaerobic oxidation of methane | Central methanogenic pathway Na+-translocating ferredoxin:NAD+ oxidoreductase rnfE 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 3.0 1.0 0.0 0.0 1.0 0.0 Carbon Fixation | Carbon Release | Organic Degration Methane-anaerobic | CH4 Anaerobic oxidation of methane | Central methanogenic pathway Na+-translocating ferredoxin:NAD+ oxidoreductase rnfG 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 2.0 1.0 0.0 0.0 0.0 0.0 Carbon Fixation | Carbon Release | Organic Degration Methane-anaerobic | CH4 Anaerobic oxidation of methane | Central methanogenic pathway Na+-translocating ferredoxin:NAD+ oxidoreductase rpe 1.0 1.0 1.0 1.0 1.0 2.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 2.0 1.0 0.0 1.0 0.0 1.0 2.0 1.0 1.0 1.0 1.0 1.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Carbohydrate | CO2 | Photosynthesis Monosaccharide | Pentose phosphate | Calvin cycle | Calvin-Benson-Bassham Cycle Ribulose-phosphate 3-epimerase rpiA 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 2.0 1.0 1.0 0.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Carbohydrate | CO2 | Photosynthesis | Organophosphorus compound Pentose phosphate | Calvin cycle | Monosaccharide | Calvin-Benson-Bassham Cycle | Pentose phosphate pathway Ribose-5-phosphate isomerase rspA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Carbohydrate Monosaccharide Mannonate dehydratase rubB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Degration Lipid Fatty acid Rubredoxin-NAD(+) reductase rutA 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Nucleotide Pyrimidine Pyrimidine monooxygenase rutE 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Nucleotide Pyrimidine Malonic semialdehyde reductase rutF 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Nucleotide Pyrimidine FMN reductase (NADH) sat 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 1.0 0.0 0.0 Organic Degration | Organic Biosynthesis Xenobiotics | Inorganic sulfur transformation Selenocompound | Dissimilatory sulfur reduction and oxidation | Assimilatory sulfate reduction Sulfate adenylyltransferase sbp 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 2.0 1.0 2.0 1.0 0.0 0.0 Transport | Organic Degration Organic sulfur cycle | ABC transport Auxiliary | ABC transport Sulfate-binding protein scnA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 scnB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 scnC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 scoA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 scpB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Carbohydrate Fermentation Methylmalonyl-CoA decarboxylase sdaB 0.0 1.0 0.0 1.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Amino acid Alcohol | Aliphatic | S side-chain L-serine dehydratase sdhA 1.0 1.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 2.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 2.0 0.0 1.0 1.0 1.0 Carbon Fixation | Organic Degration Carbohydrate | CO2 Citrate cycle | Fermentation | 3-Hydroxypropionate Bicycle | Oxidative phosphorylation | Dicarboxylate/4-hydroxybutyrate cycle Succinate dehydrogenase sdhB 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 1.0 0.0 0.0 1.0 1.0 0.0 1.0 2.0 1.0 1.0 1.0 0.0 Carbon Fixation | Organic Degration Carbohydrate | CO2 Citrate cycle | Dicarboxylate/4-hydroxybutyrate cycle | 3-Hydroxypropionate Bicycle | Oxidative phosphorylation Succinate dehydrogenase iron-sulfur subunit sdhD 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 Carbon Fixation | Organic Degration Carbohydrate | CO2 Citrate cycle | Dicarboxylate/4-hydroxybutyrate cycle | Oxidative phosphorylation Succinate dehydrogenase selA 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Xenobiotics Selenocompound L-seryl-tRNA(Sec) selenium transferase selD 0.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 1.0 1.0 Organic Biosynthesis Xenobiotics Selenocompound Selenide, water dikinase serA 1.0 1.0 1.0 1.0 1.0 4.0 1.0 2.0 1.0 2.0 1.0 2.0 1.0 1.0 2.0 2.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 0.0 2.0 2.0 1.0 0.0 1.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Amino acid | CH4 | Methane-aerobic Alcohol | S side-chain | Aerobic oxidation | Se | serine cycle D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase serB 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 2.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 2.0 1.0 0.0 1.0 0.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Amino acid | CH4 | Methane-aerobic Alcohol | Aerobic oxidation | Se | serine cycle Phosphoserine phosphatase serC 0.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Amino acid | CH4 | Methane-aerobic | Cofactor Alcohol | S side-chain | Aerobic oxidation | Vitamin B | Se | serine cycle Phosphoserine aminotransferase sfnG 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration Organic sulfur cycle Organic sulfur transformation Dimethylsulfone monooxygenase sgpB 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Organic sulfur cycle Auxiliary Sulfur globule protein CV2 sir 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Inorganic sulfur transformation Assimilatory sulfate reduction Sulfite reductase (ferredoxin) slcC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Organic sulfur cycle Organic sulfur transformation (S)-sulfolactate dehydrogenase smtB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Carbon Fixation CO2 Dicarboxylate/4-hydroxybutyrate cycle | 3-Hydroxypropionate Bicycle Succinyl-CoA:(S)-malate CoA-transferase snoaF 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Lipid Polyketide C-7 ketoreductase sod 0.0 1.0 2.0 0.0 1.0 2.0 2.0 2.0 2.0 1.0 2.0 1.0 1.0 2.0 2.0 2.0 2.0 1.0 2.0 0.0 0.0 1.0 2.0 2.0 1.0 1.0 1.0 2.0 1.0 1.0 0.0 1.0 2.0 Organic Transformation | Organic Degration Xenobiotics Lignin Superoxide dismutase soeA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Inorganic sulfur transformation Sulfur oxidation Sulfite dehydrogenase (quinone) subunit SoeA sorA 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Transformation | Organic Biosynthesis Lipid | Inorganic sulfur transformation Polyketide | Sulfur oxidation Polyketide synthase soxA 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 2.0 0.0 1.0 0.0 Organic Degration Carbohydrate | Inorganic sulfur transformation SOX systems | Oxidative phosphorylation Sarcosine oxidase soxA-K17222 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 Organic Degration Carbohydrate Oxidative phosphorylation L-cysteine S-thiosulfotransferase soxB 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 Organic Degration Carbohydrate | Inorganic sulfur transformation SOX systems | Oxidative phosphorylation Quinol oxidase soxB-K00303 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 soxC 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 1.0 1.0 1.0 0.0 Organic Degration Carbohydrate | Inorganic sulfur transformation SOX systems | Oxidative phosphorylation Cytochrome b soxD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 Organic Degration Carbohydrate | Inorganic sulfur transformation SOX systems | Oxidative phosphorylation Cytochrome c soxD-K00304 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 soxX 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 1.0 0.0 Organic Degration Inorganic sulfur transformation SOX systems L-cysteine S-thiosulfotransferase soxY 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 1.0 0.0 Organic Degration Inorganic sulfur transformation SOX systems Sulfur-oxidizing protein SoxY soxZ 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 1.0 0.0 1.0 0.0 Organic Degration Inorganic sulfur transformation SOX systems Sulfur-oxidizing protein SoxZ speA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Release | Organic Biosynthesis CO2 | Amino acid CO2 | Cationic Arginine decarboxylase speC 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Release | Organic Biosynthesis CO2 | Amino acid CO2 | Cationic Ornithine decarboxylase speD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Release | Organic Biosynthesis CO2 | Amino acid S side-chain | CO2 | Cationic S-adenosylmethionine decarboxylase proenzyme speE 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Amino acid S side-chain | Cationic Polyamine aminopropyltransferase speF 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Release CO2 CO2 Ornithine decarboxylase spnQ 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 spoT 0.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 2.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 2.0 2.0 1.0 0.0 0.0 0.0 0.0 2.0 2.0 1.0 0.0 3.0 1.0 Organic Degration | Organic Biosynthesis Organophosphorus compound | Nucleotide Purine | Purine metabolism GTP diphosphokinase / guanosine-3',5'-bis(diphosphate) 3'-diphosphatase sqdB 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Organic sulfur cycle | Lipid Organic sulfur transformation | Fatty acid UDP-sulfoquinovose synthase sqdD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration Organic sulfur cycle Organic sulfur transformation Glycosyltransferase sqdX 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Organic sulfur cycle Organic sulfur transformation Glycogen synthase sqr 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 Organic Degration Inorganic sulfur transformation Sulfur oxidation Sulfide:quinone oxidoreductase sseA 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 3.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 0.0 0.0 0.0 Organic Degration Inorganic sulfur transformation Sulfur oxidation Thiosulfate sulfurtransferase|3-mercaptopyruvate sulfurtransferase ssuB 0.0 0.0 0.0 0.0 0.0 11.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 3.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 1.0 0.0 7.0 0.0 1.0 0.0 Transport | Organic Degration Organic sulfur cycle | ABC transport Auxiliary | ABC transport Sulfonate transport system ATP-binding protein ssuC 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Transport | Organic Degration Organic sulfur cycle | ABC transport Auxiliary | ABC transport Sulfonate transport system permease protein ssuD 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration Organic sulfur cycle Link between inorganic and organic sulfur transformation Alkanesulfonate monooxygenase ssuE 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration Organic sulfur cycle | Cofactor Link between inorganic and organic sulfur transformation | Vitamin B FMN reductase sthA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 Organic Degration | Organic Biosynthesis Cofactor Vitamin B Soluble pyridine nucleotide transhydrogenase sucA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Release | Organic Degration Carbohydrate | CO2 Citrate cycle | CO2 | Pyruvate 2-oxoglutarate dehydrogenase E1 component sucC 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 1.0 Carbon Fixation | Organic Degration Carbohydrate | CO2 Citrate cycle | Dicarboxylate/4-hydroxybutyrate cycle Succinate--CoA ligase sucD 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Carbon Fixation | Organic Degration Carbohydrate | CO2 Citrate cycle | Fermentation | Dicarboxylate/4-hydroxybutyrate cycle Succinate--CoA ligase sudA 0.0 1.0 0.0 0.0 1.0 0.0 1.0 2.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 1.0 0.0 2.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 Organic Degration Inorganic sulfur transformation Sulfur reduction Sulfide dehydrogenase subunit alpha sufS 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics Selenocompound Cysteine desulfurase sugA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport ABC transport ABC transport Trehalose transport system permease protein sugB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport ABC transport ABC transport Trehalose transport system permease protein sugC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 Transport ABC transport ABC transport Trehalose import ATP-binding protein suhB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 2.0 0.0 sulP 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 Organic Degration Organic sulfur cycle Auxiliary Sulfate permease susB 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 1.0 3.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Carbohydrate Starch | Alpha-galactans Glucan 1,4-alpha-glucosidase suyA 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 2.0 0.0 Organic Degration Organic sulfur cycle Link between inorganic and organic sulfur transformation (2R)-sulfolactate sulfo-lyase subunit alpha tagD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Biosynthesis Lipid Fatty acid Glycerol-3-phosphate cytidylyltransferase tagH 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport ABC transport ABC transport Teichoic acids export ATP-binding protein tal 3.0 1.0 1.0 2.0 3.0 2.0 1.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 1.0 2.0 2.0 1.0 1.0 0.0 3.0 0.0 1.0 0.0 1.0 2.0 2.0 2.0 1.0 3.0 1.0 1.0 1.0 Organic Transformation | Organic Biosynthesis Xenobiotics Others | Lignin Phenylalanine/tyrosine ammonia-lyase tauA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Transport | Organic Degration Organic sulfur cycle | ABC transport Auxiliary | ABC transport Taurine transport system substrate-binding protein tauB 0.0 0.0 0.0 0.0 0.0 4.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3.0 0.0 3.0 0.0 Transport | Organic Degration Organic sulfur cycle | ABC transport Auxiliary | ABC transport Taurine transport system ATP-binding protein tauC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 Transport | Organic Degration Organic sulfur cycle | ABC transport Auxiliary | ABC transport Taurine transport system permease protein tauD 0.0 0.0 0.0 0.0 0.0 8.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 2.0 0.0 Carbon Release | Organic Degration Organic sulfur cycle | CO2 CO2 | Link between inorganic and organic sulfur transformation Taurine dioxygenase tauX 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration Organic sulfur cycle Organic sulfur transformation Taurine dehydrogenase small subunit tauY 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration Organic sulfur cycle Organic sulfur transformation Taurine dehydrogenase large subunit tauZ 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Organic sulfur cycle Auxiliary Membrane protein TauZ tbhA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics Lignin Toluene-3-monooxygenase oxygenase subunit 1 tbhE 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics Lignin Toluene-3-monooxygenase oxygenase subunit 2 tbuA1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Aromatics Aromatics | Lignin Toluene monooxygenase alpha subunit tbuA2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Aromatics Aromatics | Lignin Toluene monooxygenase beta subunit tbuB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Organic sulfur cycle | Aromatics Lignin | Aromatics | Link between inorganic and organic sulfur transformation Benzene/toluene monooxygenase ferredoxin subunit tbuC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Organic sulfur cycle | Aromatics Lignin | Aromatics | Link between inorganic and organic sulfur transformation Toluene monooxygenase oxidoreductase tbuU 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Aromatics Aromatics | Lignin Toluene monooxygenase gamma subunit tctA 0.0 0.0 0.0 0.0 0.0 4.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 2.0 0.0 3.0 0.0 Transport | Organic Transformation | Organic Degration Xenobiotics | Two-component system Two-component system | Lignin Tricarboxylic transport tctC 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 4.0 0.0 Transport | Organic Transformation | Organic Degration Xenobiotics | Two-component system Two-component system | Lignin Tricarboxylic transport protein tcyN 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport ABC transport ABC transport L-cystine transport system ATP-binding protein tdh 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 2.0 1.0 0.0 0.0 Organic Biosynthesis Amino acid Alcohol L-threonine 3-dehydrogenase tdk 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Nucleotide Pyrimidine Thymidine kinase tesA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation Lipid Fatty acid Thioesterase|Arylesterase|Lysophospholipase tesE 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Aromatics Organic pollutant | Aromatics 2-hydroxyhexa-2,4-dienoate hydratase tesG 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Aromatics Organic pollutant | Aromatics | Lignin 4-hydroxy-2-oxovalerate aldolase thadh 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Degration Amino acid L-Amino acid L-threo-3-hydroxyaspartate ammonia-lyase thiC 0.0 0.0 0.0 0.0 2.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 2.0 0.0 0.0 1.0 1.0 0.0 Carbon Release | Organic Biosynthesis CO | Cofactor Vitamin B | CO Phosphomethylpyrimidine synthase thiD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 Organic Biosynthesis Cofactor Vitamin B Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase thiE 2.0 0.0 0.0 0.0 0.0 2.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 2.0 1.0 3.0 2.0 1.0 0.0 Carbon Release | Organic Biosynthesis CO2 | Cofactor CO2 | Vitamin B Thiamine-phosphate synthase thiF 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 Organic Biosynthesis Cofactor Vitamin B Sulfur carrier protein ThiS adenylyltransferase thiG 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 1.0 2.0 0.0 2.0 1.0 1.0 0.0 Organic Biosynthesis Cofactor Vitamin B Thiazole synthase thiI 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B tRNA sulfurtransferase thiL 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B Thiamine-monophosphate kinase thiM 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B Hydroxyethylthiazole kinase thiO 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Biosynthesis Cofactor Vitamin B Thiamine-phosphate synthase|Glycine oxidase thrA 0.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Amino acid | Antibiotic L-Amino acid | Alcohol | S side-chain | Beta-lactam | Cationic Aspartokinase|Homoserine dehydrogenase thrB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Amino acid Alcohol Homoserine kinase thrC 1.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 0.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 0.0 2.0 1.0 1.0 2.0 2.0 1.0 0.0 Organic Biosynthesis Amino acid | Cofactor Alcohol | Vitamin B Threonine synthase thrH 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 0.0 0.0 Carbon Fixation | Organic Degration CH4 | Methane-aerobic Aerobic oxidation | serine cycle Phosphoserine / homoserine phosphotransferase thyA 0.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 1.0 1.0 Organic Degration | Organic Biosynthesis Organophosphorus compound | Cofactor | Nucleotide Pyrimidine | Vitamin B | Pyrimidine metabolism Thymidylate synthase thyX 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Cofactor | Nucleotide Pyrimidine | Vitamin B Flavin-dependent thymidylate synthase tktA 2.0 0.0 0.0 0.0 0.0 3.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 0.0 2.0 0.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Photosynthesis | Antibiotic | Carbohydrate | CO2 | Secondary metabolite Pentose phosphate | Calvin cycle | Antibiotic | Monosaccharide | Calvin-Benson-Bassham Cycle | Secondary metabolite Transketolase tktB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 1.0 0.0 1.0 0.0 Organic Degration | Carbon Fixation | Organic Biosynthesis Photosynthesis | Antibiotic | Carbohydrate | CO2 | Secondary metabolite Pentose phosphate | Calvin cycle | Antibiotic | Monosaccharide | Calvin-Benson-Bassham Cycle | Secondary metabolite Transketolase tmk 1.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 2.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 1.0 2.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 Organic Degration | Organic Biosynthesis Organophosphorus compound | Nucleotide Pyrimidine | Pyrimidine metabolism Thymidylate kinase tmoA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Aromatics Aromatics | Lignin Toluene-4-monooxygenase system, hydroxylase component subunit alpha tmoB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Aromatics Aromatics | Lignin Toluene-4-monooxygenase system, hydroxylase component subunit gamma tmoC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Organic sulfur cycle | Aromatics Lignin | Aromatics | Link between inorganic and organic sulfur transformation Toluene-4-monooxygenase system, ferredoxin component tmoD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Aromatics Aromatics | Lignin Toluene-4-monooxygenase system, effector component tmoE 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Aromatics Aromatics | Lignin Toluene-4-monooxygenase system, hydroxylase component subunit beta tnaA 0.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.0 0.0 0.0 Organic Biosynthesis Amino acid Aromatic Tryptophanase toa 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Organic sulfur cycle | Amino acid beta-amino acid | Organic sulfur transformation Taurine:2-oxoglutarate transaminase todF 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Aromatics Aromatics | Lignin 2-hydroxy-6-oxo-2,4-heptadienoate hydrolase todH 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics Lignin 4-hydroxy-2-oxovalerate aldolase todT 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration Xenobiotics Lignin Response regulator tomA4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Aromatics Aromatics Toluene ortho-monooxygenase torC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Transport | Carbon Release Two-component system | CH4 Two-component system | Methylotrophic methanogenesis Trimethylamine-N-oxide reductase tpa 1.0 0.0 0.0 0.0 0.0 3.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 2.0 3.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 Organic Degration Organic sulfur cycle Organic sulfur transformation Taurine-pyruvate aminotransferase treS 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport | Organic Degration Carbohydrate | ABC transport Starch | Hemicellulose | ABC transport Trehalose synthase troB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport ABC transport ABC transport Zinc transport system ATP-binding protein trpA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Amino acid Aromatic Tryptophan synthase alpha chain trpB 2.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 2.0 1.0 1.0 1.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 Organic Biosynthesis Amino acid Aromatic Tryptophan synthase trpC 1.0 1.0 1.0 0.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 Carbon Release | Organic Biosynthesis CO2 | Amino acid Aromatic | CO2 Indole-3-glycerol phosphate synthase trpD 1.0 1.0 1.0 0.0 1.0 2.0 1.0 1.0 0.0 2.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 1.0 2.0 1.0 1.0 1.0 1.0 1.0 0.0 Organic Biosynthesis Amino acid Aromatic Anthranilate phosphoribosyltransferase trpE 1.0 1.0 1.0 0.0 1.0 1.0 1.0 2.0 0.0 1.0 1.0 0.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 2.0 1.0 2.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 Organic Biosynthesis Amino acid Aromatic Anthranilate synthase trpG 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 2.0 1.0 1.0 1.0 1.0 3.0 1.0 0.0 0.0 0.0 2.0 1.0 2.0 1.0 1.0 0.0 Organic Biosynthesis Amino acid Aromatic Anthranilate synthase trxB 2.0 1.0 1.0 1.0 1.0 2.0 2.0 1.0 2.0 6.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 4.0 2.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 2.0 1.0 Organic Transformation | Organic Degration Xenobiotics Selenocompound | Lignin thioredoxin reductase tsaC1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Degration Aromatics Aromatics 4-formylbenzenesulfonate dehydrogenase tsdA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 Organic Degration Xenobiotics | Inorganic sulfur transformation Lignin | Sulfur oxidation Gamma-resorcylate decarboxylase tsdB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Aromatics | Inorganic sulfur transformation Aromatics | Lignin | Sulfur oxidation NADH-specific resorcinol 4-hydroxylase ttgA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics Lignin RND family efflux transporter MFP subunit ttgB 0.0 0.0 0.0 0.0 0.0 2.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 2.0 0.0 1.0 1.0 1.0 0.0 Organic Transformation | Organic Degration Xenobiotics Lignin Hydrophobe/amphiphile efflux-1 (HAE1) family protein ttrB 2.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Inorganic sulfur transformation Sulfur reduction Tetrathionate reductase subunit B ttuC 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 2.0 0.0 Carbon Release CO2 CO2 Tartrate dehydrogenase/decarboxylase|D-malate dehydrogenase [decarboxylating] tusA 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 3.0 1.0 0.0 1.0 0.0 Organic Degration Organic sulfur cycle Auxiliary Sulfur carrier protein TusA tusD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Degration Organic sulfur cycle Auxiliary Sulfurtransferase TusD tusE 1.0 0.0 1.0 1.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Organic sulfur cycle Auxiliary Sulfurtransferase TusE tviB 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Glycan O-linked UDP-N-acetylglucosamine C-6 dehydrogenase tviC 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Biosynthesis Glycan O-linked UDP-N-acetylglucosaminuronic acid C-4 epimerase tyrA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Release | Organic Biosynthesis CO2 | Amino acid | Antibiotic Aromatic | Aliphatic | CO2 | Aminoglycoside antibotics Prephenate dehydrogenase|Chorismate mutase tyrA2 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Carbon Release | Organic Biosynthesis CO2 | Amino acid | Antibiotic Aromatic | CO2 | Aminoglycoside antibotics Prephenate dehydrogenase tyrB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 2.0 0.0 0.0 1.0 0.0 Organic Degration | Organic Transformation | Organic Biosynthesis Xenobiotics | Amino acid | Secondary metabolite | Antibiotic S side-chain | Antibiotic | Aminoglycoside antibotics | Secondary metabolite | Aromatic | Aliphatic | Lignin Aromatic-amino-acid aminotransferase ubiD 1.0 1.0 1.0 0.0 0.0 2.0 0.0 0.0 1.0 0.0 0.0 1.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 Carbon Release | Organic Biosynthesis CO2 | Cofactor CO2 | Coenzyme 3-octaprenyl-4-hydroxybenzoate carboxy-lyase ubiX 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 Organic Degration | Organic Transformation | Organic Biosynthesis Aromatics | Antibiotic | Cofactor | Xenobiotics | Secondary metabolite Terpenoid | Aromatics | Vitamin B | Antibiotic | Secondary metabolite | Coenzyme | Lignin Flavin prenyltransferase ugpA 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 2.0 0.0 Organic Biosynthesis Organophosphorus compound Transmembrane transport Sn-glycerol 3-phosphate transport system permease protein ugpB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Biosynthesis Organophosphorus compound Transmembrane transport Sn-glycerol 3-phosphate transport system substrate-binding protein ugpC 0.0 0.0 0.0 0.0 0.0 10.0 1.0 3.0 0.0 2.0 0.0 1.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 2.0 3.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 2.0 15.0 2.0 3.0 0.0 Organic Biosynthesis Organophosphorus compound Transmembrane transport Sn-glycerol 3-phosphate transport system ATP-binding protein ugpE 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Biosynthesis Organophosphorus compound Transmembrane transport Sn-glycerol 3-phosphate transport system permease protein ureA 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 Organic Degration | Carbon Release | Organic Biosynthesis Nucleotide | Nitrogen cycle | Xenobiotics | CO2 | Amino acid Purine | Organic degradation and synthesis | CO2 | Herbicide | Cationic Urease ureB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 Organic Degration Nitrogen cycle Organic degradation and synthesis Urease subunit beta ureC 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 2.0 0.0 1.0 0.0 0.0 0.0 Organic Degration | Carbon Release | Organic Biosynthesis Nucleotide | Nitrogen cycle | Xenobiotics | CO2 | Amino acid Purine | Organic degradation and synthesis | CO2 | Herbicide | Cationic Urease ushA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 0.0 Organic Degration | Organic Biosynthesis Organophosphorus compound | Cofactor | Nucleotide Vitamin B | Purine | Pyrimidine | Pyrimidine metabolism | Purine metabolism 5'-nucleotidase vanA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics | Aromatics Aromatics | Lignin Vanillate O-demethylase oxygenase vanB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics | Aromatics Aromatics | Lignin Vanillate O-demethylase oxygenase vhtG 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Carbon Release CH4 Central methanogenic pathway Methanophenazine hydrogenase vioA-EC2.6.1.33 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Glycan O-linked dTDP-4-amino-4,6-dideoxy-D-glucose transaminase vipA 0.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 1.0 1.0 Organic Biosynthesis Glycan O-linked Polysaccharide biosynthesis protein vipB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Biosynthesis Glycan O-linked Polysaccharide biosynthesis protein waaA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Biosynthesis Glycan Lipopolysaccharide 3-deoxy-D-manno-octulosonic acid transferase waaD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Transformation | Organic Biosynthesis Glycan Lipopolysaccharide ADP-L-glycero-D-manno-heptose-6-epimerase waaF 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Biosynthesis Glycan Lipopolysaccharide Lipid A biosynthesis lauroyltransferase|Tetraacyldisaccharide 4'-kinase|Lipopolysaccharide heptosyltransferase waaG 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Biosynthesis Glycan Lipopolysaccharide Glucosyltransferase wbbL 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Glycan Galactoarabinan N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase|Rhamnosyltransferase WbbL wbpB 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Glycan O-linked UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate oxidase wbpD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Glycan O-linked UDP-2-acetamido-3-amino-2,3-dideoxy-D-glucuronate N-acetyltransferase wbpE 0.0 1.0 2.0 1.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 Organic Biosynthesis Glycan O-linked UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase wbpG 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Glycan O-linked LPS biosynthesis protein wbpM 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Biosynthesis Glycan O-linked Polysaccharide biosynthesis wbpP 0.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Organic Biosynthesis Glycan O-linked UDP-N-acetylglucosamine 4-epimerase|UDP-glucose 4-epimerase wbuX 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Glycan O-linked | Lipopolysaccharide Aminotransferase wecE 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Biosynthesis Glycan O-linked dTDP-4-amino-4,6-dideoxygalactose transaminase wrbA 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Cofactor Vitamin K | Coenzyme NAD(P)H dehydrogenase (quinone) xanB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Glycan | Carbohydrate Monosaccharide | O-linked Xanthan biosynthesis protein XanB xdh 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Carbohydrate Monosaccharide | Xylose-dehydratase D-xylose dehydrogenase xenB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics Lignin Xenobiotic reductase B xoxF1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Carbon Fixation | Organic Degration CH4 | Methane-aerobic Oxidation of merthane and C1 compounds | Aerobic oxidation Methanol dehydrogenase xoxF5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 Carbon Fixation | Organic Degration CH4 | Methane-aerobic Oxidation of merthane and C1 compounds | Aerobic oxidation Methanol dehydrogenase xsc 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Organic sulfur cycle Link between inorganic and organic sulfur transformation Sulfoacetaldehyde acetyltransferase xylA 0.0 0.0 1.0 0.0 0.0 0.0 0.0 2.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Carbohydrate Arabinose | Chitin | Pectin | Xylose-isomerase | Arabinan | Monosaccharide | Xylan | Beta-galactans | Xyloglucan | Hemicellulose | Beta-mannan | Cellulose Xylose isomerase xylD 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Carbohydrate Monosaccharide D-xylonate dehydratase xylE 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 2.0 2.0 1.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Aromatics Aromatics | Lignin | Styrene Catechol 2,3-dioxygenase xylF 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Aromatics Aromatics | Lignin | Styrene 2-hydroxymuconate semialdehyde hydrolase xylF-trans 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 Transport ABC transport ABC transport D-xylose ABC transporter substrate-binding protein xylG 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Aromatics Aromatics | Lignin 2-hydroxymuconic semialdehyde dehydrogenase xylG-trans 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 3.0 0.0 0.0 0.0 Transport ABC transport ABC transport Xylose import ATP-binding protein xylH 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 1.0 0.0 0.0 Organic Degration Xenobiotics | Aromatics Organic pollutant | Aromatics | Lignin 2-hydroxymuconate tautomerase xylH-trans 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 Transport ABC transport ABC transport Xylose transport system permease protein|Xylose/arabinose import permease protein|Sugar transport system permease system permease xylI 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Carbon Release | Organic Degration Xenobiotics | CO2 | Aromatics Organic pollutant | CO2 | Lignin | Aromatics 4-oxalocrotonate decarboxylase xylJ 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Aromatics Organic pollutant | Aromatics | Lignin 2-hydroxypent-2,4-dienoate hydratase xylK 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Xenobiotics | Aromatics Organic pollutant | Aromatics | Lignin 4-hydroxy-2-oxovalerate aldolase xylQ 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Xenobiotics | Carbohydrate | Aromatics Organic pollutant | Aromatics | Lignin | Pyruvate Acetaldehyde dehydrogenase xylX 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics | Aromatics Aromatics | Lignin Benzoate/Toluate 1,2-dioxygenase xylY 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics | Aromatics Aromatics | Lignin Benzoate/Toluate 1,2-dioxygenase xylZ 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Aromatics Aromatics Toluate 1,2-dioxygenase electron transfer component xynA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Carbohydrate Chitin | Arabinan | Xylan | Xyloglucan | Hemicellulose | Beta-mannan | Fucose | Cellulose Endo-1,4-beta-xylanase yafV 0.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 yagF 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Carbohydrate Monosaccharide Xylonate dehydratase yagS 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Nucleotide Purine Xanthine dehydrogenase yejB 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Transport ABC transport ABC transport Inner membrane ABC transporter permease protein yejE 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 Transport ABC transport ABC transport Inner membrane ABC transporter permease protein yejF 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Transport ABC transport ABC transport ABC transporter ATP-binding protein yesW 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Carbohydrate Pectin Rhamnogalacturonan endolyase yfeX 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation | Organic Degration Xenobiotics Lignin Dye-decolorizing peroxidase yfkN 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration | Organic Biosynthesis Cofactor | Nucleotide Purine | Pyrimidine | Vitamin B Trifunctional nucleotide phosphoesterase protein yihQ 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Organic Degration Organic sulfur cycle | Carbohydrate Organic sulfur transformation | Alpha-galactans | Starch | Sucrose | Xylan | Xyloglucan | Hemicellulose Sulfoquinovosidase yjfF 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Transport ABC transport ABC transport Inner membrane ABC transporter permease protein yjgM 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Transformation Protein Protein N-acetyltransferase yjhG 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organic Degration Carbohydrate Monosaccharide Dehydratase ytfQ 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Transport ABC transport ABC transport Galactofuranose-binding protein ytfR 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Transport ABC transport ABC transport Galactofuranose transporter ATP-binding protein ytfT 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Transport ABC transport ABC transport Galactofuranose transporter permease protein znuA 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Transport ABC transport ABC transport Zinc transport system substrate-binding protein|High-affinity zinc uptake system znuB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 Transport ABC transport ABC transport High-affinity zinc uptake system membrane protein znuC 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Transport ABC transport ABC transport Zinc import ATP-binding protein|High-affinity zinc uptake system ATP-binding protein