# emapper version: emapper-hotfix-numpy-45-g001c4bf emapper DB: 2.0 # command: ./emapper.py -m diamond --seed_ortholog_evalue 0.00001 --data_dir /home/bayegy/Databases/emapper/data_dir2.0.1/ --cpu 30 --temp_dir /media/bayegy/disk2/bayegy/pipeline_demos/binning/share_mix/Bin_all/emapper//MAG.T1.179/_tmp -i /media/bayegy/disk2/bayegy/pipeline_demos/binning/share_mix/Bin_all/Bin_prokka//MAG.T1.179/MAG.T1.179.faa -o /media/bayegy/disk2/bayegy/pipeline_demos/binning/share_mix/Bin_all/emapper//MAG.T1.179/MAG.T1.179 --usemem --override # time: Sat Jun 6 05:44:06 2026 #query_name seed_eggNOG_ortholog seed_ortholog_evalue seed_ortholog_score best_tax_level Preferred_name GOs EC KEGG_ko KEGG_Pathway KEGG_Module KEGG_Reaction KEGG_rclass BRITE KEGG_TC CAZy BiGG_Reaction taxonomic scope eggNOG OGs best eggNOG OG COG Functional cat. eggNOG free text desc. MAG.T1.179_00001 889378.Spiaf_2269 8e-149 533.9 Bacteria amyA GO:0003674,GO:0003824,GO:0004553,GO:0004556,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016160,GO:0016787,GO:0016798,GO:0044424,GO:0044464 3.2.1.1 ko:K01176 ko00500,ko01100,ko04973,map00500,map01100,map04973 R02108,R02112,R11262 ko00000,ko00001,ko01000 GH13 iECH74115_1262.ECH74115_2702,iECSP_1301.ECSP_2532,iECs_1301.ECs2666,iG2583_1286.G2583_2378,iSF_1195.SF1970 Bacteria COG0366@1,COG0366@2 NA|NA|NA G hydrolase activity, hydrolyzing O-glycosyl compounds MAG.T1.179_00002 234267.Acid_3076 9.8e-26 124.0 Acidobacteria 2.7.8.7 ko:K00997,ko:K06133 ko00770,map00770 R01625 RC00002 ko00000,ko00001,ko01000 Bacteria 3Y8HB@57723,COG2091@1,COG2091@2 NA|NA|NA H 4'-phosphopantetheinyl transferase superfamily MAG.T1.179_00003 1089455.MOPEL_080_00430 0.0 1407.1 Dermatophilaceae Bacteria 2GIZP@201174,4F7M0@85018,COG4770@1,COG4770@2,COG4799@1,COG4799@2 NA|NA|NA I Acetyl-CoA carboxylase, central region MAG.T1.179_00004 234267.Acid_3077 2.5e-227 795.4 Acidobacteria ko:K15314 ko01059,ko01130,map01059,map01130 M00824,M00825 R11435 ko00000,ko00001,ko00002,ko01008 Bacteria 3Y347@57723,COG0304@1,COG0304@2,COG3321@1,COG3321@2,COG4221@1,COG4221@2 NA|NA|NA Q Acyl transferase domain MAG.T1.179_00012 1463934.JOCF01000060_gene3408 1.4e-13 84.0 Actinobacteria Bacteria 2EGYK@1,2GRY2@201174,3493T@2 NA|NA|NA MAG.T1.179_00014 234267.Acid_3078 1.5e-188 666.0 Bacteria Bacteria COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase activity MAG.T1.179_00015 1122611.KB903985_gene3663 7.9e-133 480.7 Streptosporangiales 1.13.12.16 ko:K00459 ko00910,map00910 R00025 RC02541,RC02759 ko00000,ko00001,ko01000 Bacteria 2I93H@201174,4EIEF@85012,COG2070@1,COG2070@2 NA|NA|NA S 2-Nitropropane dioxygenase MAG.T1.179_00016 1454010.JEOE01000011_gene2396 1.3e-88 334.3 Actinobacteria Bacteria 2IBWT@201174,COG4425@1,COG4425@2 NA|NA|NA S Alpha/beta-hydrolase family MAG.T1.179_00018 290397.Adeh_2189 7.2e-36 157.9 Myxococcales Bacteria 1RAAG@1224,2WNJI@28221,2Z2RH@29,42RIX@68525,COG2030@1,COG2030@2 NA|NA|NA I MaoC like domain MAG.T1.179_00020 358823.DF19_41840 3.4e-17 95.1 Actinobacteria ssb1 ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 ko00000,ko00001,ko03029,ko03032,ko03400 Bacteria 2IGBM@201174,COG0629@1,COG0629@2 NA|NA|NA L Single-strand binding protein family MAG.T1.179_00021 1184609.KILIM_127_00030 2e-260 904.8 Dermatophilaceae yjjK GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 Bacteria 2GKBQ@201174,4F6J5@85018,COG0488@1,COG0488@2 NA|NA|NA S ABC transporter MAG.T1.179_00022 314230.DSM3645_19063 0.0 1179.9 Planctomycetes dld ko:K18930 ko00000 Bacteria 2IYAH@203682,COG0247@1,COG0247@2,COG0277@1,COG0277@2 NA|NA|NA C FAD linked oxidases, C-terminal domain MAG.T1.179_00023 983917.RGE_19390 6.9e-114 417.9 unclassified Burkholderiales ko:K03281,ko:K07085 ko00000 2.A.49,2.A.81 Bacteria 1KNQF@119065,1MUVM@1224,2VN42@28216,COG0569@1,COG0569@2,COG2985@1,COG2985@2 NA|NA|NA P Predicted Permease Membrane Region MAG.T1.179_00024 1137269.AZWL01000007_gene4285 1.3e-165 589.7 Actinobacteria 3.2.1.10,3.2.1.20,3.2.1.93 ko:K01182,ko:K01187,ko:K01226 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00028,R00801,R00802,R00837,R01718,R01791,R06087,R06088,R06113,R06199 RC00028,RC00049,RC00059,RC00077,RC00451 ko00000,ko00001,ko01000 GH13,GH31 Bacteria 2GKS4@201174,COG0366@1,COG0366@2 NA|NA|NA G alpha amylase, catalytic MAG.T1.179_00025 1463885.KL578480_gene3542 5.3e-42 177.2 Actinobacteria glbO GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008144,GO:0008150,GO:0015669,GO:0015671,GO:0015893,GO:0016020,GO:0019825,GO:0020037,GO:0036094,GO:0042221,GO:0042493,GO:0044464,GO:0046906,GO:0048037,GO:0050896,GO:0051179,GO:0051234,GO:0071944,GO:0097159,GO:1901363 ko:K06886 ko00000 Bacteria 2IKPF@201174,COG2346@1,COG2346@2 NA|NA|NA O PFAM globin MAG.T1.179_00026 1123320.KB889629_gene7846 1.9e-188 665.6 Actinobacteria Bacteria 2GIZA@201174,COG0702@1,COG0702@2 NA|NA|NA GM Nad-dependent epimerase dehydratase MAG.T1.179_00027 1089455.MOPEL_132_00510 5.3e-55 221.1 Dermatophilaceae ko:K22044 ko00000,ko02000 1.A.23.3 Bacteria 2GMFK@201174,4F6NP@85018,COG0668@1,COG0668@2 NA|NA|NA M Mechanosensitive ion channel MAG.T1.179_00029 1454010.JEOE01000011_gene2418 2.1e-217 762.3 Cellulomonadaceae malQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 2.4.1.18,2.4.1.25,3.2.1.196,5.4.99.15 ko:K00700,ko:K00705,ko:K02438,ko:K06044 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01824,R02110,R02111,R05196,R09995 RC00049 ko00000,ko00001,ko00002,ko01000,ko04147 CBM48,GH13,GH77 iJN678.malQ Bacteria 2GM5Z@201174,4F0RR@85016,COG1640@1,COG1640@2 NA|NA|NA G PFAM glycoside hydrolase family 77 MAG.T1.179_00030 471852.Tcur_1349 2.6e-272 944.9 Streptosporangiales 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 Bacteria 2GJJ4@201174,4EHVC@85012,COG0308@1,COG0308@2 NA|NA|NA E ERAP1-like C-terminal domain MAG.T1.179_00031 446471.Xcel_1105 2.1e-55 221.9 Promicromonosporaceae rpiB 5.3.1.6 ko:K01808 ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01056,R09030 RC00376,RC00434 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKJG@201174,4F4DS@85017,COG0698@1,COG0698@2 NA|NA|NA G Ribose/Galactose Isomerase MAG.T1.179_00032 367299.JOEE01000002_gene2367 4.8e-60 238.8 Intrasporangiaceae dacB 3.4.16.4 ko:K07259 ko00550,map00550 ko00000,ko00001,ko01000,ko01002,ko01011 Bacteria 2GJPH@201174,4FGTP@85021,COG2027@1,COG2027@2 NA|NA|NA M D-Ala-D-Ala carboxypeptidase 3 (S13) family MAG.T1.179_00033 1123023.JIAI01000002_gene4736 1.6e-163 582.4 Pseudonocardiales rocD GO:0003674,GO:0003824,GO:0004587,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016740,GO:0016769,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.6.1.11,2.6.1.13,2.6.1.17 ko:K00819,ko:K00821 ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R00667,R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 iYO844.BSU40340 Bacteria 2GK0J@201174,4DZYH@85010,COG4992@1,COG4992@2 NA|NA|NA E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family MAG.T1.179_00034 1313172.YM304_27660 3e-209 735.3 Bacteria Bacteria COG0433@1,COG0433@2 NA|NA|NA S helicase activity MAG.T1.179_00035 397278.JOJN01000011_gene1599 2.5e-84 319.3 Propionibacteriales Bacteria 2GJM3@201174,4DNDV@85009,COG1316@1,COG1316@2 NA|NA|NA K Cell envelope-related transcriptional attenuator domain MAG.T1.179_00036 1192034.CAP_2687 8.8e-61 240.7 Myxococcales 2.7.1.15,2.7.1.187,2.7.1.45 ko:K00852,ko:K00874,ko:K19978 ko00030,ko00525,ko01100,ko01120,ko01130,ko01200,map00030,map00525,map01100,map01120,map01130,map01200 M00061,M00308,M00631 R01051,R01541,R02750,R11184 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 1RBE0@1224,2X9ZP@28221,2YVZZ@29,4386N@68525,COG0524@1,COG0524@2 NA|NA|NA G pfkB family carbohydrate kinase MAG.T1.179_00037 765910.MARPU_00780 1.7e-104 386.3 Chromatiales gdh 1.4.1.4 ko:K00262 ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100 R00248 RC00006,RC02799 ko00000,ko00001,ko01000 Bacteria 1NPPY@1224,1RRKZ@1236,1WWQA@135613,COG4198@1,COG4198@2 NA|NA|NA S Protein of unknown function (DUF1015) MAG.T1.179_00038 909613.UO65_1997 2.6e-65 255.0 Pseudonocardiales ybhB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 ko:K06910 ko00000 Bacteria 2GMIG@201174,4DYXA@85010,COG1881@1,COG1881@2 NA|NA|NA S TIGRFAM Raf kinase inhibitor-like protein, YbhB YbcL family MAG.T1.179_00040 2045.KR76_01175 1e-31 143.7 Propionibacteriales Bacteria 2I8Y7@201174,4DU0I@85009,COG2197@1,COG2197@2 NA|NA|NA KT Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain MAG.T1.179_00041 56107.Cylst_0426 9.3e-44 185.3 Nostocales Bacteria 1GQ7S@1117,1HRXM@1161,COG0823@1,COG0823@2,COG5276@1,COG5276@2 NA|NA|NA Q LVIVD repeat MAG.T1.179_00042 1151122.AQYD01000007_gene568 2.9e-64 251.9 Microbacteriaceae phhB 3.5.4.33,4.2.1.96 ko:K01724,ko:K11991 ko00790,map00790 R04734,R10223 RC00477,RC01208 ko00000,ko00001,ko01000,ko03016,ko04147 Bacteria 2IHZE@201174,4FP56@85023,COG0596@1,COG0596@2,COG2154@1,COG2154@2 NA|NA|NA H Pterin 4 alpha carbinolamine dehydratase MAG.T1.179_00043 590998.Celf_1077 1.4e-56 226.5 Cellulomonadaceae ko:K02081,ko:K03436 ko00000,ko03000 Bacteria 2GKWM@201174,4F32F@85016,COG1349@1,COG1349@2 NA|NA|NA K DeoR C terminal sensor domain MAG.T1.179_00044 263358.VAB18032_19950 8.4e-92 343.6 Micromonosporales estA ko:K03930 ko00000,ko01000 CE1 Bacteria 2GJX4@201174,4D9HJ@85008,COG0627@1,COG0627@2 NA|NA|NA S Putative esterase MAG.T1.179_00046 1265502.KB905943_gene2772 1.3e-266 925.6 Comamonadaceae fadH 1.3.1.34 ko:K00219 ko00000,ko01000 Bacteria 1MVE0@1224,2VIW3@28216,4ABSX@80864,COG0446@1,COG0446@2,COG1902@1,COG1902@2 NA|NA|NA C NADH flavin oxidoreductase NADH oxidase MAG.T1.179_00047 1172188.KB911822_gene882 2.7e-145 522.3 Intrasporangiaceae ko:K06158 ko00000,ko03012 Bacteria 2GK9S@201174,4FFDZ@85021,COG0488@1,COG0488@2 NA|NA|NA S ABC transporter, ATP-binding protein MAG.T1.179_00048 1035308.AQYY01000001_gene3456 1.5e-58 233.4 Clostridia Bacteria 1UZ78@1239,24BM7@186801,COG3965@1,COG3965@2 NA|NA|NA P cation diffusion facilitator family transporter MAG.T1.179_00049 356851.JOAN01000007_gene4066 3.5e-41 175.6 Micromonosporales 1.3.1.84,4.2.1.116,6.2.1.36 ko:K14469 ko00720,ko01120,ko01200,map00720,map01120,map01200 M00376 R00919,R03045,R09286 RC00004,RC00014,RC00095,RC00834 ko00000,ko00001,ko00002,ko01000 Bacteria 2I8SZ@201174,4DFFZ@85008,COG0604@1,COG0604@2 NA|NA|NA C alcohol dehydrogenase MAG.T1.179_00050 1246995.AFR_19415 6.2e-33 146.7 Micromonosporales ko:K10947 ko00000,ko03000 Bacteria 2IQ51@201174,4DFEK@85008,COG1695@1,COG1695@2 NA|NA|NA K Transcriptional regulator PadR-like family MAG.T1.179_00051 1035308.AQYY01000001_gene3431 0.0 1412.5 Peptococcaceae glgP GO:0000272,GO:0003674,GO:0003824,GO:0004645,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0005977,GO:0005980,GO:0006073,GO:0006091,GO:0006112,GO:0008144,GO:0008150,GO:0008152,GO:0008184,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0015980,GO:0016052,GO:0016740,GO:0016757,GO:0016758,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901575 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 R02111 ko00000,ko00001,ko01000 GT35 Bacteria 1TQAJ@1239,248E1@186801,260JM@186807,COG0058@1,COG0058@2 NA|NA|NA G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties MAG.T1.179_00052 443218.AS9A_2736 9.4e-130 469.9 Mycobacteriaceae Bacteria 236RA@1762,2I8ND@201174,COG3832@1,COG3832@2 NA|NA|NA S Activator of Hsp90 ATPase 1 family protein MAG.T1.179_00053 443218.AS9A_2735 2.6e-40 171.4 Mycobacteriaceae Bacteria 239ZN@1762,2IQ55@201174,COG0640@1,COG0640@2 NA|NA|NA K regulatory protein, arsR MAG.T1.179_00054 991905.SL003B_1297 6.1e-145 520.8 unclassified Alphaproteobacteria phlC 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1MUZV@1224,2TRHF@28211,4BSJ0@82117,COG0183@1,COG0183@2 NA|NA|NA I acetyl-coa acetyltransferase MAG.T1.179_00055 991905.SL003B_1298 1.2e-35 156.0 Proteobacteria ko:K07068 ko00000 Bacteria 1RJZS@1224,COG1545@1,COG1545@2 NA|NA|NA S Rubredoxin-like zinc ribbon domain (DUF35_N) MAG.T1.179_00057 471855.Shel_11220 1.5e-66 260.0 Coriobacteriia pta 2.3.1.8 ko:K00625,ko:K13788 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00230,R00921 RC00004,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ5U@201174,4CVRI@84998,COG0280@1,COG0280@2 NA|NA|NA C PFAM Phosphate acetyl butaryl transferase MAG.T1.179_00058 367299.JOEE01000001_gene1505 3.2e-118 432.2 Intrasporangiaceae enhA_2 Bacteria 2GQ7D@201174,4FIVF@85021,COG1376@1,COG1376@2 NA|NA|NA S Putative peptidoglycan binding domain MAG.T1.179_00059 446470.Snas_0470 1.8e-152 545.8 Glycomycetales bioA 2.6.1.105,2.6.1.62 ko:K00833,ko:K19563 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03231,R10699 RC00006,RC00062,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 iSB619.SA_RS12705 Bacteria 2I2DN@201174,4EY5T@85014,COG0161@1,COG0161@2 NA|NA|NA H Aminotransferase class-III MAG.T1.179_00060 1048339.KB913029_gene3297 1.2e-109 404.4 Frankiales bioF GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0030312,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0071944,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.29,2.3.1.47 ko:K00639,ko:K00652 ko00260,ko00780,ko01100,map00260,map00780,map01100 M00123,M00573,M00577 R00371,R03210,R10124 RC00004,RC00039,RC00394,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 iJN678.bioF,iNJ661.Rv1569 Bacteria 2GISV@201174,4ERNK@85013,COG0156@1,COG0156@2 NA|NA|NA E aminotransferase class I and II MAG.T1.179_00061 479432.Sros_8310 1.9e-63 249.6 Streptosporangiales bioD GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004141,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017076,GO:0017144,GO:0018130,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.47,6.3.3.3 ko:K00652,ko:K01935 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03182,R03210,R10124 RC00004,RC00039,RC00868,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 2GIZ2@201174,4EIRW@85012,COG0132@1,COG0132@2 NA|NA|NA H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring MAG.T1.179_00062 1136417.AZWE01000018_gene953 2.4e-144 518.5 Micromonosporales bioB GO:0003674,GO:0003824,GO:0004076,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0017144,GO:0018130,GO:0019752,GO:0030312,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0070283,GO:0071704,GO:0071944,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1589,iZ_1308.Z0994 Bacteria 2GIUE@201174,4D8R0@85008,COG0502@1,COG0502@2 NA|NA|NA H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism MAG.T1.179_00063 1123024.AUII01000004_gene1673 8e-14 82.8 Pseudonocardiales GO:0002682,GO:0002684,GO:0008150,GO:0009605,GO:0009607,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0075136 Bacteria 2EH0W@1,2GSW1@201174,33ASY@2,4E7W5@85010 NA|NA|NA MAG.T1.179_00064 1150398.JIBJ01000006_gene3690 1.1e-12 79.3 Actinobacteria Bacteria 2DQ6J@1,2GTCR@201174,334Z3@2 NA|NA|NA S Excalibur calcium-binding domain MAG.T1.179_00065 1385518.N798_07485 1.3e-10 75.1 Intrasporangiaceae 3.2.1.4 ko:K01179,ko:K11904,ko:K20276 ko00500,ko01100,ko02024,ko03070,map00500,map01100,map02024,map03070 M00334 R06200,R11307,R11308 ko00000,ko00001,ko00002,ko01000,ko02044 3.A.23.1 GH5,GH9 Bacteria 2I7XV@201174,4FK2V@85021,COG4733@1,COG4733@2,COG4932@1,COG4932@2 NA|NA|NA M Fibronectin type III domain MAG.T1.179_00066 926564.KI911630_gene3158 8.1e-37 161.4 Promicromonosporaceae Bacteria 2DM4W@1,2IK0R@201174,31QNY@2,4F4T1@85017 NA|NA|NA S Winged helix DNA-binding domain MAG.T1.179_00067 1172188.KB911822_gene839 8.8e-56 223.0 Intrasporangiaceae Bacteria 298UU@1,2HY02@201174,2ZVYZ@2,4FIZB@85021 NA|NA|NA S Domain of unknown function (DU1801) MAG.T1.179_00068 1385518.N798_12125 1.6e-51 208.8 Intrasporangiaceae Bacteria 2AKGE@1,2I885@201174,30DHP@2,4FH35@85021 NA|NA|NA MAG.T1.179_00069 1298863.AUEP01000019_gene3531 2e-23 115.2 Actinobacteria Bacteria 2AEBM@1,2HDPF@201174,31462@2 NA|NA|NA MAG.T1.179_00070 1121924.ATWH01000014_gene3488 5.3e-10 70.9 Microbacteriaceae Bacteria 2GYNE@201174,4FSSM@85023,COG2250@1,COG2250@2 NA|NA|NA S HEPN domain MAG.T1.179_00071 710696.Intca_0333 4.4e-27 128.3 Intrasporangiaceae Bacteria 2GUWM@201174,4FJA2@85021,COG1708@1,COG1708@2 NA|NA|NA L Nucleotidyltransferase domain MAG.T1.179_00074 313589.JNB_05894 7.7e-103 380.9 Intrasporangiaceae tig GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944 ko:K03545 ko00000 Bacteria 2GJIG@201174,4FF93@85021,COG0544@1,COG0544@2 NA|NA|NA D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase MAG.T1.179_00075 1048339.KB913029_gene4876 1.7e-84 318.9 Frankiales clpP 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 ko00000,ko00001,ko01000,ko01002 Bacteria 2GK5C@201174,4ES45@85013,COG0740@1,COG0740@2 NA|NA|NA O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins MAG.T1.179_00076 1504319.GM45_5765 1.5e-91 342.4 unclassified Actinobacteria (class) clpP GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 ko00000,ko00001,ko01000,ko01002 Bacteria 2GKNK@201174,3UWGF@52018,COG0740@1,COG0740@2 NA|NA|NA O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins MAG.T1.179_00077 656024.FsymDg_1521 9.5e-194 682.9 Frankiales clpX GO:0000166,GO:0000502,GO:0002020,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009376,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019899,GO:0019904,GO:0030163,GO:0030164,GO:0030312,GO:0030554,GO:0031333,GO:0031597,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0043335,GO:0044087,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0051704,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0097718,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 ko:K03544 ko04112,map04112 ko00000,ko00001,ko03110 Bacteria 2GJXQ@201174,4ERKD@85013,COG1219@1,COG1219@2 NA|NA|NA O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP MAG.T1.179_00080 1268303.RHODMAR_2172 6.1e-20 104.0 Nocardiaceae 3.1.1.1 ko:K03928 ko00000,ko01000 Bacteria 2HJV3@201174,4G7FC@85025,COG1647@1,COG1647@2 NA|NA|NA S Serine aminopeptidase, S33 MAG.T1.179_00081 1048339.KB913029_gene4866 7.8e-136 490.7 Frankiales folC 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJP2@201174,4ERQF@85013,COG0285@1,COG0285@2 NA|NA|NA H Mur ligase, middle domain protein MAG.T1.179_00082 1120936.KB907209_gene1847 6.3e-11 73.6 Bacteria Bacteria 2EHND@1,33BE5@2 NA|NA|NA S Protein of unknown function (DUF4233) MAG.T1.179_00083 1380356.JNIK01000001_gene2188 3.8e-48 197.6 Frankiales ndk GO:0003674,GO:0003824,GO:0004518,GO:0004550,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006464,GO:0006468,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016787,GO:0016788,GO:0018995,GO:0019205,GO:0019538,GO:0019637,GO:0033643,GO:0033646,GO:0033647,GO:0033648,GO:0034641,GO:0036211,GO:0042025,GO:0043170,GO:0043412,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044464,GO:0046483,GO:0046777,GO:0046939,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072527,GO:0090304,GO:0090305,GO:1901360,GO:1901564 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 iNJ661.Rv2445c Bacteria 2IFBU@201174,4ESUM@85013,COG0105@1,COG0105@2 NA|NA|NA F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate MAG.T1.179_00084 543632.JOJL01000008_gene5922 1.1e-120 439.9 Micromonosporales ppk2 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008976,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0044237 2.7.4.1 ko:K22468 ko00190,ko03018,map00190,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 2GKRN@201174,4DBU4@85008,COG2326@1,COG2326@2 NA|NA|NA S Polyphosphate kinase 2 (PPK2) MAG.T1.179_00085 471852.Tcur_1544 3.9e-300 1036.9 Streptosporangiales Bacteria 2GJY1@201174,4EFRZ@85012,COG1032@1,COG1032@2 NA|NA|NA C Elongator protein 3, MiaB family, Radical SAM MAG.T1.179_00086 1380356.JNIK01000001_gene2193 6.2e-65 254.2 Frankiales Bacteria 2GIS7@201174,4ESGF@85013,COG5011@1,COG5011@2 NA|NA|NA S Uncharacterized protein conserved in bacteria (DUF2344) MAG.T1.179_00087 561175.KB894104_gene1142 5.4e-213 748.0 Streptosporangiales rne GO:0006139,GO:0006364,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016072,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 3.1.26.12 ko:K08300,ko:K08301 ko03018,map03018 M00394 ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 Bacteria 2GMM5@201174,4EGIT@85012,COG1530@1,COG1530@2 NA|NA|NA J Ribonuclease E/G family MAG.T1.179_00088 1048339.KB913029_gene4852 1.3e-32 145.6 Frankiales rplU GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02888 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IQ9A@201174,4ET3X@85013,COG0261@1,COG0261@2 NA|NA|NA J This protein binds to 23S rRNA in the presence of protein L20 MAG.T1.179_00089 471856.Jden_1651 6.7e-35 152.9 Actinobacteria rpmA GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904 ko:K02899 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IQDI@201174,COG0211@1,COG0211@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL27 family MAG.T1.179_00090 1123322.KB904724_gene1934 5.7e-177 627.5 Actinobacteria obg GO:0000287,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019538,GO:0032991,GO:0036211,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046777,GO:0046872,GO:0071704,GO:0071944,GO:1901564,GO:1990904 ko:K03979 ko00000,ko01000,ko03009 Bacteria 2GISB@201174,COG0536@1,COG0536@2 NA|NA|NA S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control MAG.T1.179_00091 105425.BBPL01000002_gene6561 4.3e-124 451.4 Streptacidiphilus proB GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 Bacteria 2GM8U@201174,2NG7R@228398,COG0263@1,COG0263@2 NA|NA|NA E Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase MAG.T1.179_00092 500153.JOEK01000011_gene1945 1.3e-155 556.2 Actinobacteria proA GO:0003674,GO:0003824,GO:0004350,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016620,GO:0016903,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 iLJ478.TM0293,iNJ661.Rv2427c,iYO844.BSU13130 Bacteria 2GISA@201174,COG0014@1,COG0014@2 NA|NA|NA E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate MAG.T1.179_00094 1123024.AUII01000008_gene1827 3.9e-75 287.7 Pseudonocardiales nadD GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.7.18,3.6.1.55 ko:K00969,ko:K03574 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 Bacteria 2GMFZ@201174,4E0CB@85010,COG1057@1,COG1057@2 NA|NA|NA H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) MAG.T1.179_00095 351607.Acel_0763 4.2e-44 185.7 Frankiales Bacteria 2GNGN@201174,4EWPJ@85013,COG1316@1,COG1316@2 NA|NA|NA K LytR cell envelope-related transcriptional attenuator MAG.T1.179_00096 1306174.JODP01000011_gene6740 3e-39 167.9 Actinobacteria rsfS GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090071,GO:2000112,GO:2000113 2.7.7.18 ko:K00969,ko:K09710 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000,ko03009 Bacteria 2IKZ3@201174,COG0799@1,COG0799@2 NA|NA|NA S Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation MAG.T1.179_00097 253839.SSNG_02327 7.5e-57 227.3 Actinobacteria gpmB GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0044237 3.1.3.73,3.1.3.85 ko:K02226,ko:K22306 ko00860,ko01100,map00860,map01100 M00122 R04594,R11173 RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJYU@201174,COG0406@1,COG0406@2 NA|NA|NA G Belongs to the phosphoglycerate mutase family MAG.T1.179_00099 1380354.JIAN01000009_gene3895 3.3e-13 81.3 Actinobacteria Bacteria 2EGDD@1,2GR3X@201174,33A58@2 NA|NA|NA S Phospholipase_D-nuclease N-terminal MAG.T1.179_00100 1504319.GM45_5885 0.0 1257.3 unclassified Actinobacteria (class) leuS 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 Bacteria 2GJI1@201174,3UWBT@52018,COG0495@1,COG0495@2 NA|NA|NA J Leucyl-tRNA synthetase, Domain 2 MAG.T1.179_00101 1289387.AUKW01000018_gene2044 8.5e-63 247.3 Actinobacteria Bacteria 2GIUV@201174,COG1307@1,COG1307@2 NA|NA|NA S DegV family MAG.T1.179_00102 1386089.N865_01635 1.8e-35 156.0 Intrasporangiaceae plsY 2.3.1.15 ko:K03977,ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004,ko03009 Bacteria 2IF8Y@201174,4FG1E@85021,COG0344@1,COG0344@2 NA|NA|NA I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP MAG.T1.179_00103 1122138.AQUZ01000017_gene6611 6e-28 131.3 Propionibacteriales comEA ko:K02237 M00429 ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 Bacteria 2IQDC@201174,4DRFZ@85009,COG1555@1,COG1555@2 NA|NA|NA L Helix-hairpin-helix motif MAG.T1.179_00104 994479.GL877878_gene2770 1.2e-93 351.3 Pseudonocardiales comEC ko:K02238 M00429 ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 Bacteria 2GJGR@201174,4DXGV@85010,COG0658@1,COG0658@2,COG2333@1,COG2333@2 NA|NA|NA S DNA internalization-related competence protein ComEC Rec2 MAG.T1.179_00105 479433.Caci_7073 3.3e-41 176.0 Actinobacteria holA 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 2GNMZ@201174,COG1466@1,COG1466@2 NA|NA|NA L DNA polymerase III delta subunit MAG.T1.179_00106 675635.Psed_2013 4.5e-23 113.6 Pseudonocardiales rpsT GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030234,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0042979,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050790,GO:0065003,GO:0065007,GO:0065009,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02968 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IQ73@201174,4E5HA@85010,COG0268@1,COG0268@2 NA|NA|NA J Binds directly to 16S ribosomal RNA MAG.T1.179_00107 479433.Caci_7070 1.3e-289 1001.9 Actinobacteria lepA GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 ko:K03596 ko05134,map05134 ko00000,ko00001 Bacteria 2GJAB@201174,COG0481@1,COG0481@2 NA|NA|NA M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner MAG.T1.179_00109 1869.MB27_31595 1.9e-98 365.9 Micromonosporales f42a Bacteria 2GM0Z@201174,4DBBQ@85008,COG0330@1,COG0330@2 NA|NA|NA O prohibitin homologues MAG.T1.179_00110 1435356.Y013_20760 3.3e-19 100.9 Nocardiaceae Bacteria 2GQV1@201174,4G3V1@85025,COG4877@1,COG4877@2 NA|NA|NA MAG.T1.179_00111 710421.Mycch_0373 1.2e-186 659.8 Mycobacteriaceae 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 Bacteria 235IH@1762,2GIXQ@201174,COG1022@1,COG1022@2 NA|NA|NA I synthetase MAG.T1.179_00113 1120950.KB892739_gene4000 6.2e-131 474.2 Propionibacteriales hemN GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 iNJ661.Rv2388c Bacteria 2GJXX@201174,4DN32@85009,COG0635@1,COG0635@2 NA|NA|NA H Involved in the biosynthesis of porphyrin-containing compound MAG.T1.179_00114 1123508.JH636440_gene2073 7.6e-09 67.4 Planctomycetes Bacteria 2J1MD@203682,COG2314@1,COG2314@2 NA|NA|NA S TM2 domain MAG.T1.179_00115 58344.JOEL01000008_gene1598 6.3e-90 337.4 Actinobacteria trpH GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004532,GO:0004534,GO:0004536,GO:0004540,GO:0005488,GO:0006139,GO:0006259,GO:0006521,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008409,GO:0009987,GO:0010565,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016796,GO:0016895,GO:0016896,GO:0019222,GO:0030145,GO:0031323,GO:0033238,GO:0034641,GO:0035312,GO:0042578,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:0090357,GO:0090501,GO:0090503,GO:0097657,GO:0140097,GO:0140098,GO:1901360 3.1.3.97 ko:K07053 R00188,R11188 RC00078 ko00000,ko01000 Bacteria 2GIZ5@201174,COG0613@1,COG0613@2 NA|NA|NA S Protein of unknown function (DUF3097) MAG.T1.179_00116 1134445.AJJM01000004_gene3443 1.7e-118 432.6 Actinobacteria hrcA GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 ko:K03705 ko00000,ko03000 Bacteria 2GKF5@201174,COG1420@1,COG1420@2 NA|NA|NA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons MAG.T1.179_00117 47763.JNZA01000003_gene3958 9.9e-147 526.6 Actinobacteria dnaJ GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944 ko:K03686 ko00000,ko03029,ko03110 Bacteria 2GK69@201174,COG0484@1,COG0484@2 NA|NA|NA O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins MAG.T1.179_00118 67352.JODS01000019_gene2705 8.1e-65 253.8 Actinobacteria rsmE 1.13.12.16,2.1.1.193 ko:K00459,ko:K09761 ko00910,map00910 R00025 RC02541,RC02759 ko00000,ko00001,ko01000,ko03009 Bacteria 2GTKX@201174,COG1385@1,COG1385@2 NA|NA|NA J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit MAG.T1.179_00119 40571.JOEA01000016_gene46 5.9e-31 140.2 Pseudonocardiales hinT GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019478,GO:0019752,GO:0043436,GO:0043530,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046144,GO:0046395,GO:0046416,GO:0046436,GO:0055130,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.1.1.226,2.1.1.227 ko:K02503,ko:K06442 ko00000,ko01000,ko03009,ko04147 Bacteria 2IHPT@201174,4E5MT@85010,COG0537@1,COG0537@2 NA|NA|NA FG HIT family hydrolase, diadenosine tetraphosphate hydrolase MAG.T1.179_00120 1122609.AUGT01000023_gene513 1.8e-131 475.7 Propionibacteriales phoH GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K06217 ko00000 Bacteria 2GK0W@201174,4DPI2@85009,COG1702@1,COG1702@2 NA|NA|NA T PhoH-like protein MAG.T1.179_00121 570268.ANBB01000046_gene1392 8.7e-46 189.9 Streptosporangiales ybeY GO:0000469,GO:0000478,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0006139,GO:0006355,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016072,GO:0016151,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0019219,GO:0019222,GO:0019538,GO:0022613,GO:0030490,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043244,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141 2.6.99.2,3.5.4.5 ko:K01489,ko:K03474,ko:K03595,ko:K07042 ko00240,ko00750,ko00983,ko01100,map00240,map00750,map00983,map01100 M00124 R01878,R02485,R05838,R08221 RC00074,RC00514,RC01476 ko00000,ko00001,ko00002,ko01000,ko03009,ko03029 Bacteria 2GMUF@201174,4EIYX@85012,COG0319@1,COG0319@2 NA|NA|NA S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA MAG.T1.179_00122 1120936.KB907220_gene1928 1.6e-119 436.4 Streptosporangiales corC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 2GIWR@201174,4EFYG@85012,COG1253@1,COG1253@2 NA|NA|NA S Transporter associated domain MAG.T1.179_00123 1463856.JOHY01000067_gene7125 3.7e-115 421.4 Actinobacteria era GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043021,GO:0043024,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070181,GO:0070925,GO:0071826,GO:0071840,GO:0097159,GO:1901363 ko:K03595 ko00000,ko03009,ko03029 Bacteria 2GJJE@201174,COG1159@1,COG1159@2 NA|NA|NA M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism MAG.T1.179_00124 526225.Gobs_3844 4.5e-141 508.1 Frankiales deaD 3.6.4.13 ko:K05592,ko:K11927 ko03018,map03018 ko00000,ko00001,ko01000,ko03009,ko03019 Bacteria 2GIUR@201174,4ES4U@85013,COG0513@1,COG0513@2 NA|NA|NA L DEAD DEAH box helicase domain protein MAG.T1.179_00125 1172188.KB911821_gene1489 5.5e-82 311.6 Intrasporangiaceae Bacteria 2GN4Y@201174,4FF71@85021,COG0628@1,COG0628@2 NA|NA|NA S AI-2E family transporter MAG.T1.179_00126 471853.Bcav_1766 2.9e-83 315.1 Actinobacteria recO GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 ko:K03584 ko03440,map03440 ko00000,ko00001,ko03400 Bacteria 2GK81@201174,COG1381@1,COG1381@2 NA|NA|NA L Involved in DNA repair and RecF pathway recombination MAG.T1.179_00127 397278.JOJN01000001_gene3042 7.3e-28 130.6 Propionibacteriales Bacteria 2GWCE@201174,4DV6A@85009,COG2453@1,COG2453@2 NA|NA|NA T Dual specificity phosphatase, catalytic domain MAG.T1.179_00128 58123.JOFJ01000001_gene3316 7.3e-118 430.3 Streptosporangiales uppS GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008834,GO:0009058,GO:0009987,GO:0016020,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030145,GO:0033850,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0046914,GO:0050347,GO:0071704,GO:0071944,GO:1901576,GO:1901615,GO:1901617 2.5.1.31,2.5.1.86,2.5.1.88 ko:K00806,ko:K14215,ko:K21273 ko00900,ko01110,map00900,map01110 R06447,R09244,R09731 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 Bacteria 2GIXF@201174,4EG00@85012,COG0020@1,COG0020@2 NA|NA|NA I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids MAG.T1.179_00130 1504319.GM45_0330 1.3e-225 788.9 unclassified Actinobacteria (class) glyQS GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009345,GO:0009987,GO:0010467,GO:0016070,GO:0016594,GO:0016597,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0042165,GO:0042802,GO:0042803,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046983,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.14 ko:K01880 ko00970,map00970 M00359,M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 iSB619.SA_RS07880 Bacteria 2GIT3@201174,3UW9K@52018,COG0423@1,COG0423@2 NA|NA|NA J Catalyzes the attachment of glycine to tRNA(Gly) MAG.T1.179_00132 1048339.KB913029_gene4777 9.7e-128 463.4 Frankiales dus Bacteria 2GJ8I@201174,4ERGB@85013,COG0042@1,COG0042@2 NA|NA|NA J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines MAG.T1.179_00133 1504822.CCNO01000011_gene176 5.1e-97 361.7 unclassified Bacteria malS 3.2.1.1 ko:K01176 ko00500,ko01100,ko04973,map00500,map01100,map04973 R02108,R02112,R11262 ko00000,ko00001,ko01000 GH13 Bacteria 2NPAG@2323,COG0366@1,COG0366@2 NA|NA|NA G PFAM Alpha amylase, catalytic MAG.T1.179_00134 1160137.KB907307_gene3773 2.2e-160 572.4 Nocardiaceae aglA 3.2.1.10,3.2.1.20,3.2.1.93 ko:K01182,ko:K01187,ko:K01226 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00028,R00801,R00802,R00837,R01718,R01791,R06087,R06088,R06113,R06199 RC00028,RC00049,RC00059,RC00077,RC00451 ko00000,ko00001,ko01000 GH13,GH31 Bacteria 2GKS4@201174,4FUMW@85025,COG0366@1,COG0366@2 NA|NA|NA G Alpha-amylase domain MAG.T1.179_00135 44060.JODL01000005_gene651 0.0 1279.6 Actinobacteria ppdK 2.7.3.13,2.7.9.1 ko:K01006,ko:K22424 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 Bacteria 2GK73@201174,COG0574@1,COG0574@2,COG1080@1,COG1080@2 NA|NA|NA G Belongs to the PEP-utilizing enzyme family MAG.T1.179_00136 1123322.KB904724_gene2000 3.7e-131 474.9 Actinobacteria dgt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.1.5.1 ko:K01129 ko00230,map00230 R01856 RC00017 ko00000,ko00001,ko01000 Bacteria 2GJ8F@201174,COG0232@1,COG0232@2 NA|NA|NA F Deoxyguanosinetriphosphate triphosphohydrolase-like protein MAG.T1.179_00137 1123023.JIAI01000007_gene1976 5e-30 137.9 Pseudonocardiales Bacteria 2I2NF@201174,4E2P9@85010,COG1434@1,COG1434@2 NA|NA|NA S DUF218 domain MAG.T1.179_00138 351607.Acel_0806 1.6e-179 636.3 Frankiales dnaG GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 ko:K02316 ko03030,map03030 ko00000,ko00001,ko01000,ko03032 Bacteria 2GJFX@201174,4ERCW@85013,COG0358@1,COG0358@2 NA|NA|NA L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication MAG.T1.179_00139 469371.Tbis_1189 2.7e-19 102.1 Actinobacteria hup GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009889,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2001141 ko:K03530 ko00000,ko03032,ko03036,ko03400 Bacteria 2IR95@201174,COG0776@1,COG0776@2 NA|NA|NA L regulation of translation MAG.T1.179_00140 1122622.ATWJ01000013_gene243 7.9e-22 111.7 Intrasporangiaceae 4.4.1.32 ko:K02289 ko00196,ko01100,map00196,map01100 ko00000,ko00001,ko00194,ko01000 Bacteria 2GITU@201174,4FGE0@85021,COG1413@1,COG1413@2 NA|NA|NA C HEAT repeats MAG.T1.179_00141 1035308.AQYY01000002_gene584 1.8e-39 170.2 Peptococcaceae nolA ko:K19591 M00769 ko00000,ko00002,ko01504,ko03000 Bacteria 1V8GZ@1239,25M6J@186801,26621@186807,COG0789@1,COG0789@2 NA|NA|NA K helix_turn_helix, mercury resistance MAG.T1.179_00144 1907.SGLAU_10165 1.4e-53 216.9 Actinobacteria Bacteria 2GKT0@201174,COG0583@1,COG0583@2 NA|NA|NA K transcriptional regulator MAG.T1.179_00147 1003195.SCAT_3393 4.2e-61 241.5 Actinobacteria trmB GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0040007,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.297,2.1.1.33,2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02493,ko:K02527,ko:K03439 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763,R10806 RC00003,RC00009,RC00077,RC00247,RC03279 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005,ko03012,ko03016 GT30 Bacteria 2GJ8R@201174,COG0220@1,COG0220@2 NA|NA|NA J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA MAG.T1.179_00148 1385520.N802_05395 2.1e-64 252.3 Intrasporangiaceae 1.5.1.40 ko:K06988 ko00000,ko01000 Bacteria 2GMN3@201174,4FJWG@85021,COG2085@1,COG2085@2 NA|NA|NA S NADP oxidoreductase MAG.T1.179_00149 298654.FraEuI1c_5203 5.3e-125 454.1 Frankiales yhhW_2 ko:K06911 ko00000 Bacteria 2GIY9@201174,4ES53@85013,COG1741@1,COG1741@2 NA|NA|NA S Belongs to the pirin family MAG.T1.179_00150 1123322.KB904701_gene313 3.7e-107 394.8 Actinobacteria mutY ko:K03575 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 2GJD9@201174,COG1194@1,COG1194@2 NA|NA|NA L adenine glycosylase MAG.T1.179_00153 1035308.AQYY01000001_gene3247 2.7e-19 101.3 Clostridia Bacteria 1TRFZ@1239,24PYJ@186801,COG1808@1,COG1808@2 NA|NA|NA S Hydrophobic domain MAG.T1.179_00155 1236902.ANAS01000009_gene2473 4.6e-73 282.3 Streptosporangiales 3.5.1.104 ko:K22278 ko00000,ko01000 Bacteria 2HEQK@201174,4EI91@85012,COG0726@1,COG0726@2 NA|NA|NA G Polysaccharide deacetylase MAG.T1.179_00158 1172179.AUKV01000029_gene7734 1.9e-91 342.8 Actinobacteria pstA GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0010921,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0019220,GO:0019222,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0031323,GO:0033554,GO:0034220,GO:0035303,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0051716,GO:0055085,GO:0065007,GO:0065009,GO:0071944,GO:0098656,GO:0098660,GO:0098661 ko:K02037,ko:K02038 ko02010,map02010 M00222 ko00000,ko00001,ko00002,ko02000 3.A.1.7 iJN746.PP_2658,iPC815.YPO4115,iYL1228.KPN_04131,iZ_1308.Z5217 Bacteria 2I2F2@201174,COG0581@1,COG0581@2 NA|NA|NA P phosphate transport system permease MAG.T1.179_00159 1095772.CAHH01000068_gene347 3.9e-110 404.4 Actinobacteria pstB 3.6.3.27 ko:K02036 ko02010,map02010 M00222 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 Bacteria 2GJQ3@201174,COG1117@1,COG1117@2 NA|NA|NA P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system MAG.T1.179_00160 526226.Gbro_2863 2e-82 312.8 Gordoniaceae GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009436,GO:0009987,GO:0015977,GO:0016054,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0032787,GO:0043427,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046185,GO:0046395,GO:0046487,GO:0071704,GO:0072329,GO:1901575 4.1.3.4,4.1.3.46 ko:K01640,ko:K18314 ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146 M00036,M00088 R01360,R08090,R10674 RC00502,RC00503,RC01118,RC01205,RC01946 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKTP@201174,4GBZC@85026,COG0119@1,COG0119@2 NA|NA|NA E HMGL-like MAG.T1.179_00161 1380347.JNII01000006_gene1701 3.3e-129 468.4 Frankiales glgC GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0008878,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016772,GO:0016779,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0070566,GO:0071704,GO:1901576 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2768 Bacteria 2I2EF@201174,4ERNH@85013,COG0448@1,COG0448@2 NA|NA|NA H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans MAG.T1.179_00162 345341.KUTG_04253 5e-138 497.7 Pseudonocardiales glgA GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0071704,GO:1901576 2.4.1.342 ko:K16148 ko00500,ko01100,map00500,map01100 R02421,R11530 RC00005,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 GT4 Bacteria 2I2EE@201174,4E0K3@85010,COG0297@1,COG0297@2 NA|NA|NA G Glycosyl transferase 4-like domain MAG.T1.179_00163 397278.JOJN01000007_gene3359 3.7e-117 428.7 Propionibacteriales Bacteria 2GWA2@201174,2Z9VM@2,4DQ3R@85009,COG1524@1 NA|NA|NA S mannose-ethanolamine phosphotransferase activity MAG.T1.179_00165 1050202.KB913024_gene55 2.7e-116 425.6 Actinopolysporales Bacteria 2GKGM@201174,407NC@622450,COG2733@1,COG2733@2 NA|NA|NA S Protein of unknown function (DUF445) MAG.T1.179_00166 1032480.MLP_00530 3.9e-107 395.2 Propionibacteriales pit ko:K03306 ko00000 2.A.20 Bacteria 2GJHK@201174,4DND5@85009,COG0306@1,COG0306@2 NA|NA|NA P Phosphate transporter family MAG.T1.179_00167 101510.RHA1_ro03323 2.2e-90 338.6 Nocardiaceae Bacteria 2GMSB@201174,4FXCP@85025,COG2013@1,COG2013@2 NA|NA|NA T Mitochondrial biogenesis AIM24 MAG.T1.179_00168 1120950.KB892759_gene6277 2.4e-77 296.2 Propionibacteriales Bacteria 2I2J0@201174,4DQBJ@85009,COG2385@1,COG2385@2 NA|NA|NA D PFAM Stage II sporulation D domain protein MAG.T1.179_00169 1229780.BN381_100067 3.7e-60 238.4 unclassified Actinobacteria (class) hrtA 3.6.3.25 ko:K02003,ko:K06020,ko:K09810,ko:K09814 ko02010,map02010 M00255,M00257,M00258 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.125 Bacteria 2GNB3@201174,3UXF5@52018,COG1136@1,COG1136@2 NA|NA|NA V ATPases associated with a variety of cellular activities MAG.T1.179_00170 1313172.YM304_38290 1.5e-38 167.2 Actinobacteria ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GMC4@201174,COG0577@1,COG0577@2 NA|NA|NA V ABC-type antimicrobial peptide transport system, permease component MAG.T1.179_00171 1229780.BN381_100069 3.5e-32 146.0 Bacteria ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria COG0577@1,COG0577@2 NA|NA|NA V efflux transmembrane transporter activity MAG.T1.179_00172 1120949.KB903328_gene8960 7.2e-09 68.6 Micromonosporales Bacteria 2DMZ3@1,2IQMH@201174,32UHB@2,4DFK7@85008 NA|NA|NA S Predicted membrane protein (DUF2157) MAG.T1.179_00173 479432.Sros_8729 6.3e-148 530.8 Streptosporangiales nplT 3.2.1.1 ko:K01176 ko00500,ko01100,ko04973,map00500,map01100,map04973 R02108,R02112,R11262 ko00000,ko00001,ko01000 GH13 Bacteria 2GJUT@201174,4EIF5@85012,COG0366@1,COG0366@2 NA|NA|NA G Alpha amylase, catalytic domain MAG.T1.179_00174 768671.ThimaDRAFT_1447 2.9e-79 302.8 Chromatiales ggt 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 Bacteria 1MUV6@1224,1SMH6@1236,1X0JB@135613,COG0405@1,COG0405@2 NA|NA|NA E Gamma-glutamyltranspeptidase MAG.T1.179_00175 1205910.B005_1121 1.4e-93 350.1 Streptosporangiales amiA ko:K01436,ko:K06048 ko00000,ko01000,ko01002 Bacteria 2GK05@201174,4EHXK@85012,COG1473@1,COG1473@2 NA|NA|NA S Peptidase dimerisation domain MAG.T1.179_00176 926569.ANT_20770 3.1e-16 90.9 Chloroflexi mrx1 1.20.4.3 ko:K18917 ko00000,ko01000 Bacteria 2G75B@200795,COG0695@1,COG0695@2 NA|NA|NA O Glutathione S-transferase, N-terminal domain MAG.T1.179_00177 1121017.AUFG01000020_gene2298 2.4e-37 161.8 Intrasporangiaceae dcdA 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 Bacteria 2IJ94@201174,4FHCM@85021,COG2131@1,COG2131@2 NA|NA|NA F MafB19-like deaminase MAG.T1.179_00178 1306174.JODP01000001_gene5170 1.7e-50 206.5 Actinobacteria yeaD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716 4.2.1.9,5.1.3.15 ko:K01687,ko:K01792 ko00010,ko00290,ko00770,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00010,map00290,map00770,map01100,map01110,map01120,map01130,map01210,map01230 M00019,M00570 R01209,R02739,R04441,R05070 RC00468,RC00563,RC01714 ko00000,ko00001,ko00002,ko01000 Bacteria 2IIUH@201174,COG0676@1,COG0676@2 NA|NA|NA G Belongs to the glucose-6-phosphate 1-epimerase family MAG.T1.179_00179 1305732.JAGG01000001_gene909 5.3e-109 402.1 Actinobacteria ykoD 3.6.3.24 ko:K02031,ko:K02032,ko:K10824,ko:K15587,ko:K16785,ko:K16786,ko:K16787 ko02010,ko02024,map02010,map02024 M00239,M00440,M00582 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35,3.A.1.5 Bacteria 2I2G4@201174,COG0619@1,COG0619@2,COG1123@1,COG4172@2 NA|NA|NA P Cobalt transport protein MAG.T1.179_00180 1122182.KB903816_gene1683 1.1e-53 216.5 Micromonosporales ykoE ko:K16925 M00582 ko00000,ko00002,ko02000 3.A.1.30 Bacteria 2IDAN@201174,4D9S6@85008,COG4721@1,COG4721@2 NA|NA|NA S ABC-type cobalt transport system, permease component MAG.T1.179_00181 2002.JOEQ01000009_gene6516 1.6e-62 246.1 Streptosporangiales yplQ ko:K11068 ko00000,ko02042 Bacteria 2GJGQ@201174,4EIGX@85012,COG1272@1,COG1272@2 NA|NA|NA S Haemolysin-III related MAG.T1.179_00182 411459.RUMOBE_00192 7.4e-11 73.2 Blautia Bacteria 1VEJY@1239,24QJW@186801,3Y0K2@572511,COG3326@1,COG3326@2 NA|NA|NA S Psort location CytoplasmicMembrane, score MAG.T1.179_00183 195250.CM001776_gene511 1.5e-76 293.1 Synechococcus 1.1.1.219 ko:K00091 ko00000,ko01000 Bacteria 1G2DP@1117,1H3Z1@1129,COG0451@1,COG0451@2 NA|NA|NA M NmrA-like family MAG.T1.179_00185 1172188.KB911821_gene1996 9.1e-155 553.9 Intrasporangiaceae Bacteria 2HXIC@201174,4FH0P@85021,COG0471@1,COG0471@2 NA|NA|NA P Sodium:sulfate symporter transmembrane region MAG.T1.179_00186 326424.FRAAL6407 8.7e-153 547.4 Frankiales atzF 3.5.1.54 ko:K01457 ko00220,ko00791,ko01100,ko01120,map00220,map00791,map01100,map01120 R00005 RC02756 ko00000,ko00001,ko01000 Bacteria 2GSBS@201174,4ERN1@85013,COG0154@1,COG0154@2,COG2105@1,COG2105@2 NA|NA|NA J Amidase MAG.T1.179_00187 365528.KB891208_gene2813 3.8e-107 394.4 Frankiales rutB Bacteria 2I9AW@201174,4ERJC@85013,COG1335@1,COG1335@2 NA|NA|NA Q PFAM Isochorismatase MAG.T1.179_00188 1209072.ALBT01000033_gene1686 2.2e-23 115.9 Gammaproteobacteria rutB Bacteria 1MV0W@1224,1RU8R@1236,COG1335@1,COG1335@2 NA|NA|NA Q Amidases related to nicotinamidase MAG.T1.179_00189 1123258.AQXZ01000014_gene4982 7e-120 437.2 Nocardiaceae ko:K02058,ko:K07335 M00221 ko00000,ko00002,ko02000 3.A.1.2 Bacteria 2HHEG@201174,4FY9I@85025,COG1744@1,COG1744@2 NA|NA|NA S ABC transporter substrate-binding protein PnrA-like MAG.T1.179_00190 298654.FraEuI1c_0532 6.9e-108 397.5 Actinobacteria rbsC-2 ko:K02057 M00221 ko00000,ko00002,ko02000 3.A.1.2 Bacteria 2GKMB@201174,COG1079@1,COG1079@2 NA|NA|NA S Belongs to the binding-protein-dependent transport system permease family MAG.T1.179_00191 298654.FraEuI1c_0533 3e-97 362.1 Frankiales ko:K02057 M00221 ko00000,ko00002,ko02000 3.A.1.2 Bacteria 2GKAZ@201174,4EU1I@85013,COG4603@1,COG4603@2 NA|NA|NA S Belongs to the binding-protein-dependent transport system permease family MAG.T1.179_00192 1123258.AQXZ01000014_gene4985 1.4e-167 596.3 Nocardiaceae mglA 3.6.3.17 ko:K02056 M00221 ko00000,ko00002,ko01000,ko02000 3.A.1.2 Bacteria 2H7KJ@201174,4G9EK@85025,COG3845@1,COG3845@2 NA|NA|NA S ATPases associated with a variety of cellular activities MAG.T1.179_00193 326424.FRAAL6405 2.7e-71 275.4 Frankiales ntaR Bacteria 2IDZ6@201174,4ET86@85013,COG1802@1,COG1802@2 NA|NA|NA K FCD MAG.T1.179_00194 479433.Caci_6448 2e-59 235.7 Actinobacteria Bacteria 2F0VE@1,2INWW@201174,33TX8@2 NA|NA|NA MAG.T1.179_00195 446471.Xcel_0031 1.9e-111 409.5 Actinobacteria Bacteria 2GWBV@201174,COG1672@1,COG1672@2 NA|NA|NA S AAA ATPase domain MAG.T1.179_00196 1122599.AUGR01000005_gene1973 2.5e-126 459.1 Oceanospirillales Bacteria 1MWUX@1224,1RQ8G@1236,1XK8Z@135619,COG0076@1,COG0076@2 NA|NA|NA E Glutamate decarboxylase and related PLP-dependent MAG.T1.179_00197 479435.Kfla_0655 1.4e-35 155.6 Propionibacteriales Bacteria 2IKXW@201174,4DR3R@85009,COG3824@1,COG3824@2 NA|NA|NA S Zincin-like metallopeptidase MAG.T1.179_00198 1121272.KB903289_gene4351 2.3e-95 355.5 Actinobacteria Bacteria 2IB3X@201174,COG5640@1,COG5640@2 NA|NA|NA O Trypsin-like serine protease MAG.T1.179_00199 1211815.CBYP010000045_gene795 1.3e-78 300.4 Frankiales ybdK GO:0003674,GO:0003824,GO:0016874,GO:0016879 ko:K06048 ko00000,ko01000 Bacteria 2GKAA@201174,4ES1F@85013,COG2170@1,COG2170@2 NA|NA|NA S ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity MAG.T1.179_00200 1304865.JAGF01000001_gene1186 6.4e-155 555.1 Actinobacteria Bacteria 2IAWA@201174,COG2199@1,COG2202@1,COG2202@2,COG3706@2 NA|NA|NA T diguanylate cyclase MAG.T1.179_00201 1380356.JNIK01000013_gene4301 2.1e-50 204.9 Frankiales Bacteria 2GR1G@201174,4EWZ9@85013,COG3631@1,COG3631@2 NA|NA|NA S SnoaL-like polyketide cyclase MAG.T1.179_00202 1380370.JIBA01000006_gene3355 3.3e-83 314.7 Intrasporangiaceae ko:K07118 ko00000 Bacteria 2GK2P@201174,4FH0H@85021,COG2910@1,COG2910@2 NA|NA|NA S NAD(P)H-binding MAG.T1.179_00203 1380370.JIBA01000011_gene3042 3.5e-135 488.0 Intrasporangiaceae Bacteria 299PK@1,2ICYR@201174,2ZWRX@2,4FEZK@85021 NA|NA|NA S Rifampin ADP-ribosyl transferase MAG.T1.179_00204 1380393.JHVP01000015_gene4172 2.1e-58 231.9 Frankiales 3.2.2.1 ko:K01239 ko00230,ko00760,ko01100,map00230,map00760,map01100 R01245,R01273,R01677,R01770,R02143 RC00033,RC00063,RC00122,RC00318,RC00485 ko00000,ko00001,ko01000 Bacteria 2IFKS@201174,4EVNQ@85013,COG0346@1,COG0346@2 NA|NA|NA E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily MAG.T1.179_00205 1385520.N802_03220 2.4e-261 908.7 Intrasporangiaceae vpr GO:0005575,GO:0005576 ko:K14647 ko02024,map02024 ko00000,ko00001,ko01000,ko01002,ko03110 Bacteria 2GK3D@201174,4FE2Y@85021,COG1404@1,COG1404@2 NA|NA|NA O PA domain MAG.T1.179_00206 357808.RoseRS_1515 4.2e-12 78.2 Chloroflexia Bacteria 2DRD4@1,2G9Z1@200795,33B9X@2,377FH@32061 NA|NA|NA MAG.T1.179_00207 477641.MODMU_2166 6.6e-49 200.7 Frankiales Bacteria 2IIBU@201174,308PC@2,4EV3D@85013,arCOG14808@1 NA|NA|NA S Domain of unknown function (DUF4956) MAG.T1.179_00208 1869.MB27_41620 4.7e-48 198.4 Micromonosporales ygiF GO:0003674,GO:0003824,GO:0005488,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0043167,GO:0043169,GO:0046872,GO:0050355 3.6.1.25 ko:K18446 ko00000,ko01000 Bacteria 2II2C@201174,4DCSN@85008,COG3025@1,COG3025@2 NA|NA|NA S VTC domain MAG.T1.179_00209 1095767.CAHD01000028_gene1705 4.4e-64 252.7 Cellulomonadaceae Bacteria 2GKIT@201174,2Z8AD@2,4F0EE@85016,arCOG08054@1 NA|NA|NA S Carbohydrate-binding domain-containing protein Cthe_2159 MAG.T1.179_00211 110319.CF8_3589 5.2e-66 258.8 Propionibacteriales Bacteria 2ICM5@201174,4DQ8D@85009,COG4421@1,COG4421@2 NA|NA|NA G Protein of unknown function (DUF563) MAG.T1.179_00212 479431.Namu_0418 1.9e-88 332.8 Frankiales Bacteria 2GIS3@201174,4EU7J@85013,COG0604@1,COG0604@2 NA|NA|NA C alcohol dehydrogenase MAG.T1.179_00213 1385519.N801_00245 6.8e-64 250.8 Intrasporangiaceae Bacteria 2DBV7@1,2IGRZ@201174,2ZB9P@2,4FHPC@85021 NA|NA|NA S Domain of unknown function (DUF4386) MAG.T1.179_00214 1304865.JAGF01000001_gene432 8e-18 96.3 Actinobacteria Bacteria 2DBV7@1,2IGRZ@201174,2ZB9P@2 NA|NA|NA S Domain of unknown function (DUF4386) MAG.T1.179_00215 1172188.KB911822_gene696 6.2e-243 847.4 Intrasporangiaceae ko:K03556 ko00000,ko03000 Bacteria 2HEX2@201174,4FF31@85021,COG2909@1,COG2909@2 NA|NA|NA K helix_turn_helix, Lux Regulon MAG.T1.179_00216 479431.Namu_0429 1.8e-99 369.4 Frankiales 1.8.1.9 ko:K00384 ko00450,map00450 R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 Bacteria 2GIXN@201174,4ESGA@85013,COG0492@1,COG0492@2 NA|NA|NA O Pyridine nucleotide-disulphide oxidoreductase MAG.T1.179_00217 1032480.MLP_34390 2.1e-44 185.3 Propionibacteriales adk 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2I45A@201174,4DSTH@85009,COG0563@1,COG0563@2 NA|NA|NA F AAA domain MAG.T1.179_00219 1171373.PACID_21720 3.8e-27 127.5 Actinobacteria Bacteria 2GXCS@201174,COG2361@1,COG2361@2 NA|NA|NA S Protein of unknown function DUF86 MAG.T1.179_00220 1035308.AQYY01000001_gene2076 1.3e-44 186.0 Bacteria ko:K07075 ko00000 Bacteria COG1669@1,COG1669@2 NA|NA|NA S nucleotidyltransferase activity MAG.T1.179_00222 1321778.HMPREF1982_01855 1e-59 237.3 Clostridia 2.7.1.15,2.7.1.187,2.7.1.45 ko:K00852,ko:K00874,ko:K19978 ko00030,ko00525,ko01100,ko01120,ko01130,ko01200,map00030,map00525,map01100,map01120,map01130,map01200 M00061,M00308,M00631 R01051,R01541,R02750,R11184 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 1TRRQ@1239,24D41@186801,COG0524@1,COG0524@2 NA|NA|NA G pfkB family carbohydrate kinase MAG.T1.179_00223 446470.Snas_3927 5.7e-19 101.3 Glycomycetales Bacteria 2GQRD@201174,4EZTI@85014,COG1309@1,COG1309@2 NA|NA|NA K Tetracyclin repressor, C-terminal all-alpha domain MAG.T1.179_00225 1386089.N865_05300 2.3e-24 119.4 Actinobacteria Bacteria 2BFB8@1,2ISHF@201174,32949@2 NA|NA|NA MAG.T1.179_00227 471853.Bcav_3697 1e-70 273.9 Actinobacteria Bacteria 2GIS3@201174,COG0604@1,COG0604@2 NA|NA|NA C alcohol dehydrogenase MAG.T1.179_00228 1206737.BAGF01000151_gene6270 2.4e-72 279.3 Nocardiaceae Bacteria 2GIS3@201174,4FYN0@85025,COG0604@1,COG0604@2 NA|NA|NA C Zinc-binding dehydrogenase MAG.T1.179_00230 710696.Intca_0451 7.1e-304 1049.7 Intrasporangiaceae 3.2.1.20 ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 GH31 Bacteria 2GP4V@201174,4FG4A@85021,COG1501@1,COG1501@2 NA|NA|NA G Glycosyl hydrolases family 31 MAG.T1.179_00231 1110697.NCAST_20_03040 6.3e-22 110.9 Nocardiaceae Bacteria 2IRV0@201174,4G0MZ@85025,COG0542@1,COG0542@2 NA|NA|NA O Clp amino terminal domain, pathogenicity island component MAG.T1.179_00232 749927.AMED_5979 3.3e-13 80.5 Pseudonocardiales Bacteria 2E3V5@1,2GTV6@201174,345UQ@2,4ED36@85010 NA|NA|NA S Homeodomain-like domain MAG.T1.179_00234 1386089.N865_19910 3.2e-119 435.3 Intrasporangiaceae ko:K07222 ko00000 Bacteria 2GM3S@201174,4FFFI@85021,COG2072@1,COG2072@2 NA|NA|NA P L-lysine 6-monooxygenase (NADPH-requiring) MAG.T1.179_00236 710111.FraQA3DRAFT_1948 1.8e-149 536.2 Frankiales Bacteria 28H9S@1,2HZP4@201174,2Z7ME@2,4EU66@85013 NA|NA|NA S GDSL-like Lipase/Acylhydrolase MAG.T1.179_00237 1003195.SCAT_2410 1.2e-20 106.7 Actinobacteria ligT GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008104,GO:0008150,GO:0009966,GO:0010646,GO:0010738,GO:0023051,GO:0033036,GO:0034237,GO:0044424,GO:0044444,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0051018,GO:0051179,GO:0065007,GO:1902531 3.1.4.58 ko:K01975 ko00000,ko01000,ko03016 Bacteria 2GNDN@201174,COG1514@1,COG1514@2 NA|NA|NA J Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester MAG.T1.179_00238 998088.B565_1091 1.5e-24 119.4 Proteobacteria Bacteria 1NKFS@1224,COG3832@1,COG3832@2 NA|NA|NA S Activator of Hsp90 ATPase homolog 1-like protein MAG.T1.179_00239 1380393.JHVP01000002_gene1784 1.5e-140 505.8 Frankiales mdh 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 Bacteria 2GN5S@201174,4ESBM@85013,COG0039@1,COG0039@2 NA|NA|NA C Catalyzes the reversible oxidation of malate to oxaloacetate MAG.T1.179_00240 1120950.KB892760_gene5727 6.2e-10 70.5 Bacteria Bacteria 2DRQP@1,33CNM@2 NA|NA|NA S Protein of unknown function (DUF3017) MAG.T1.179_00241 269800.Tfu_2571 2.9e-115 421.8 Streptosporangiales folD GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0040007,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJZS@201174,4EH3U@85012,COG0190@1,COG0190@2 NA|NA|NA H Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate MAG.T1.179_00242 633149.Bresu_2234 7.2e-65 254.2 Caulobacterales MA20_05625 Bacteria 1MU9Y@1224,2KF3K@204458,2TUH0@28211,COG0647@1,COG0647@2 NA|NA|NA G Hydrolase MAG.T1.179_00243 44060.JODL01000002_gene2206 1.2e-211 742.7 Actinobacteria purH GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 iHN637.CLJU_RS04230,iJN678.purH Bacteria 2GJWU@201174,COG0138@1,COG0138@2 NA|NA|NA F Bifunctional purine biosynthesis protein PurH MAG.T1.179_00244 43354.JOIJ01000010_gene2460 3.3e-64 251.5 Pseudonocardiales purN GO:0000287,GO:0003674,GO:0005488,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019752,GO:0034641,GO:0042558,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0046483,GO:0046653,GO:0046872,GO:0051186,GO:0071704,GO:1901360,GO:1901564 2.1.2.2,2.1.2.3,3.5.4.10 ko:K00602,ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04325,R04326,R04560 RC00026,RC00197,RC00263,RC00456,RC01128 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2H8QB@201174,4DY8H@85010,COG0299@1,COG0299@2 NA|NA|NA F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate MAG.T1.179_00245 1120950.KB892760_gene5721 1.7e-22 114.0 Propionibacteriales ko:K07148 ko00000 Bacteria 2GKA8@201174,4DQSU@85009,COG2311@1,COG2311@2 NA|NA|NA S Membrane MAG.T1.179_00246 1043205.AFYF01000057_gene2681 2.1e-120 438.7 Intrasporangiaceae sucD 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 Bacteria 2GK00@201174,4FFWQ@85021,COG0074@1,COG0074@2 NA|NA|NA C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit MAG.T1.179_00247 649831.L083_1047 5.4e-140 504.2 Micromonosporales sucC 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKSB@201174,4DAKW@85008,COG0045@1,COG0045@2 NA|NA|NA C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit MAG.T1.179_00248 710696.Intca_1058 1.9e-50 205.3 Intrasporangiaceae icmB 5.4.99.13,5.4.99.2,5.4.99.63 ko:K01849,ko:K11942,ko:K14447 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R00833,R09292 RC00395,RC02835 ko00000,ko00001,ko00002,ko01000 Bacteria 2IFJD@201174,4FGQ3@85021,COG2185@1,COG2185@2 NA|NA|NA I B12 binding domain MAG.T1.179_00249 1123320.KB889574_gene5500 1.5e-272 945.7 Actinobacteria pcrA GO:0000018,GO:0000166,GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030312,GO:0030554,GO:0031323,GO:0031324,GO:0032392,GO:0032508,GO:0032552,GO:0032554,GO:0032558,GO:0032564,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0036094,GO:0040007,GO:0042623,GO:0043138,GO:0043140,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0045910,GO:0045934,GO:0046483,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051276,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 2GISS@201174,COG0210@1,COG0210@2 NA|NA|NA L DNA helicase MAG.T1.179_00250 1504319.GM45_2400 3.2e-46 193.0 Actinobacteria ko:K01446 R04112 RC00064,RC00141 ko00000 Bacteria 2IG5X@201174,COG3409@1,COG3409@2 NA|NA|NA M Peptidoglycan-binding domain 1 protein MAG.T1.179_00251 1146883.BLASA_4228 1.3e-75 289.7 Frankiales Bacteria 2GMVD@201174,4ESNR@85013,COG2120@1,COG2120@2 NA|NA|NA S Evidence 2b Function of strongly homologous gene MAG.T1.179_00252 1304865.JAGF01000001_gene590 1e-22 112.8 Bacteria Bacteria 2E4PN@1,32ZIA@2 NA|NA|NA MAG.T1.179_00253 1394178.AWOO02000003_gene2641 1e-76 293.1 Streptosporangiales degU ko:K07684 ko02020,map02020 M00471 ko00000,ko00001,ko00002,ko02022 Bacteria 2GIVA@201174,4EHIU@85012,COG2197@1,COG2197@2 NA|NA|NA T helix_turn_helix, Lux Regulon MAG.T1.179_00254 58123.JOFJ01000019_gene3792 3.7e-67 262.3 Streptosporangiales tcsS3 Bacteria 2GJ4J@201174,4EG3Q@85012,COG1983@1,COG1983@2,COG4585@1,COG4585@2 NA|NA|NA KT PspC domain MAG.T1.179_00255 1048339.KB913029_gene2814 4.4e-18 99.4 Frankiales Bacteria 2GIVS@201174,4EW85@85013,COG1983@1,COG1983@2 NA|NA|NA KT PFAM PspC domain protein MAG.T1.179_00257 1121946.AUAX01000003_gene1480 3.9e-234 817.4 Micromonosporales guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 iJN746.PP_1032,iSF_1195.SF2553,iSFxv_1172.SFxv_2808,iS_1188.S2725,iYL1228.KPN_02833 Bacteria 2GM09@201174,4DAVN@85008,COG0519@1,COG0519@2 NA|NA|NA F Catalyzes the synthesis of GMP from XMP MAG.T1.179_00258 345341.KUTG_05928 5.2e-198 697.6 Pseudonocardiales choD GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009405,GO:0016491,GO:0016614,GO:0016899,GO:0016995,GO:0044419,GO:0051704,GO:0055114 1.1.3.6 ko:K03333 ko00984,ko01120,map00984,map01120 R01459 RC00146 ko00000,ko00001,ko01000 Bacteria 2GJ3J@201174,4DYHW@85010,COG2303@1,COG2303@2 NA|NA|NA E Catalyzes the oxidation and isomerization of cholesterol to cholestenone (4-cholesten-3-one), which is an initial step in the cholesterol degradation process. Required for virulence MAG.T1.179_00259 1184609.KILIM_065_00100 2e-145 522.7 Dermatophilaceae gabD2 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009013,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016620,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0071944,GO:0072350 1.2.1.16,1.2.1.20,1.2.1.79,1.2.99.10 ko:K00135,ko:K22445 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ95@201174,4F6MX@85018,COG1012@1,COG1012@2 NA|NA|NA C Aldehyde dehydrogenase family MAG.T1.179_00260 105420.BBPO01000010_gene2316 2e-146 526.2 Streptacidiphilus glpD 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 R00848 RC00029 ko00000,ko00001,ko01000 Bacteria 2GJKN@201174,2NHAR@228398,COG0578@1,COG0578@2 NA|NA|NA C C-terminal domain of alpha-glycerophosphate oxidase MAG.T1.179_00261 1120950.KB892783_gene342 2.5e-147 528.5 Propionibacteriales guaB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GKVS@201174,4DN1G@85009,COG0516@1,COG0516@2 NA|NA|NA F IMP dehydrogenase / GMP reductase domain MAG.T1.179_00262 1095767.CAHD01000133_gene1273 1.5e-227 795.4 Cellulomonadaceae guaB GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006183,GO:0006195,GO:0006204,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009125,GO:0009126,GO:0009127,GO:0009128,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009154,GO:0009156,GO:0009158,GO:0009161,GO:0009163,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009169,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009261,GO:0009987,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046037,GO:0046039,GO:0046040,GO:0046128,GO:0046129,GO:0046390,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0072523,GO:0090407,GO:0097292,GO:0097293,GO:1901068,GO:1901070,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GITZ@201174,4F0EC@85016,COG0516@1,COG0516@2,COG0517@1,COG0517@2 NA|NA|NA F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth MAG.T1.179_00263 1306174.JODP01000006_gene3624 5.1e-65 254.2 Actinobacteria bldM Bacteria 2GN46@201174,COG2197@1,COG2197@2 NA|NA|NA K Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain MAG.T1.179_00264 710421.Mycch_1110 7.9e-14 84.7 Mycobacteriaceae Bacteria 233QX@1762,2F0NR@1,2GUJF@201174,33TR6@2 NA|NA|NA MAG.T1.179_00265 675635.Psed_5357 5e-58 231.9 Pseudonocardiales litR ko:K22491 ko00000,ko03000 Bacteria 2I8T8@201174,4DZZC@85010,COG0789@1,COG0789@2 NA|NA|NA K MerR HTH family regulatory protein MAG.T1.179_00266 1114959.SZMC14600_05067 3e-34 151.0 Pseudonocardiales whiB3 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0008152,GO:0009273,GO:0009405,GO:0009987,GO:0010565,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0019216,GO:0019217,GO:0019222,GO:0019725,GO:0030312,GO:0031323,GO:0042546,GO:0042592,GO:0043254,GO:0044085,GO:0044087,GO:0044419,GO:0044464,GO:0045454,GO:0048037,GO:0048583,GO:0050789,GO:0050794,GO:0051128,GO:0051536,GO:0051539,GO:0051540,GO:0051704,GO:0055114,GO:0062012,GO:0065007,GO:0065008,GO:0071554,GO:0071766,GO:0071840,GO:0071944,GO:0080090,GO:0080134,GO:0090034,GO:0097159,GO:1901363,GO:1902882 ko:K18955 ko00000,ko03000 Bacteria 2CC1Y@1,2IQS5@201174,32S23@2,4E4SU@85010 NA|NA|NA K Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA MAG.T1.179_00267 1122622.ATWJ01000007_gene1560 5.1e-221 773.9 Intrasporangiaceae groL GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006457,GO:0006458,GO:0006725,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009266,GO:0009295,GO:0009408,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016465,GO:0030312,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042026,GO:0042262,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043388,GO:0043590,GO:0044093,GO:0044183,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0050896,GO:0051082,GO:0051098,GO:0051099,GO:0051101,GO:0051716,GO:0061077,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090143,GO:0090304,GO:0097159,GO:0101031,GO:1901360,GO:1901363,GO:1990220,GO:2000677,GO:2000679 ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 Bacteria 2GKC9@201174,4FF25@85021,COG0459@1,COG0459@2 NA|NA|NA O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions MAG.T1.179_00268 1306174.JODP01000006_gene3620 6.1e-40 169.9 Actinobacteria groS GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 ko:K04078 ko00000,ko03029,ko03110 Bacteria 2IKTH@201174,COG0234@1,COG0234@2 NA|NA|NA O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter MAG.T1.179_00269 1157640.AQWO01000012_gene167 1.1e-67 264.2 Actinobacteria Bacteria 2GK97@201174,COG2265@1,COG2265@2 NA|NA|NA J COG0500 SAM-dependent methyltransferases MAG.T1.179_00271 1306174.JODP01000003_gene1895 7e-36 157.5 Actinobacteria Bacteria 2I8Y7@201174,COG2197@1,COG2197@2 NA|NA|NA KT Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain MAG.T1.179_00272 1169161.KB897730_gene1069 3.1e-12 80.9 Actinobacteria Bacteria 2I8JH@201174,COG4585@1,COG4585@2 NA|NA|NA T signal transduction histidine kinase MAG.T1.179_00273 1184609.KILIM_003_00270 3.2e-152 544.7 Dermatophilaceae tsaD GO:0000287,GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140030,GO:0140032,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 ko:K01409,ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 R10648 RC00070,RC00416 ko00000,ko00001,ko00002,ko01000,ko02044,ko03016 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 Bacteria 2GJ98@201174,4F606@85018,COG0533@1,COG0533@2 NA|NA|NA J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction MAG.T1.179_00274 235985.BBPN01000023_gene2700 4.5e-27 127.9 Streptacidiphilus rimI GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008999,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0017189,GO:0018193,GO:0018194,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564 2.3.1.128,2.3.1.234 ko:K01409,ko:K03789,ko:K14742 R10648 RC00070,RC00416 ko00000,ko01000,ko03009,ko03016 Bacteria 2IM9R@201174,2NH04@228398,COG0454@1,COG0456@2 NA|NA|NA K Acetyltransferase (GNAT) domain MAG.T1.179_00275 1449353.JQMQ01000005_gene3688 9.7e-46 190.3 Streptacidiphilus yeaZ GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0071944,GO:0090304,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 ko:K01409,ko:K14742 R10648 RC00070,RC00416 ko00000,ko01000,ko03016 Bacteria 2GMTM@201174,2NF90@228398,COG1214@1,COG1214@2 NA|NA|NA O Glycoprotease family MAG.T1.179_00276 935839.JAGJ01000006_gene3358 5.9e-44 184.1 Promicromonosporaceae ydiB GO:0002949,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.7.1.221,5.1.1.1 ko:K01775,ko:K06925,ko:K07102 ko00473,ko00520,ko01100,ko01502,map00473,map00520,map01100,map01502 R00401,R08968,R11024 RC00002,RC00078,RC00285 ko00000,ko00001,ko01000,ko01011,ko03016 Bacteria 2IKV2@201174,4F4GX@85017,COG0802@1,COG0802@2 NA|NA|NA S Threonylcarbamoyl adenosine biosynthesis protein TsaE MAG.T1.179_00277 479432.Sros_1142 5.3e-82 311.6 Streptosporangiales Bacteria 2GMCK@201174,4EFMQ@85012,COG2267@1,COG2267@2 NA|NA|NA I Serine aminopeptidase, S33 MAG.T1.179_00278 1380346.JNIH01000003_gene2082 1.9e-118 432.6 Actinobacteria alr GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008784,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0019842,GO:0030170,GO:0030203,GO:0034645,GO:0036094,GO:0036361,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0047661,GO:0048037,GO:0050662,GO:0070279,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 R00401 RC00285 ko00000,ko00001,ko01000,ko01011 iEC55989_1330.EC55989_1285,iECIAI39_1322.ECIAI39_1880,iECO103_1326.ECO103_1292,iECO26_1355.ECO26_1703,iECSE_1348.ECSE_1238,iECUMN_1333.ECUMN_1479,iECW_1372.ECW_m1275,iEKO11_1354.EKO11_2666,iEcE24377_1341.EcE24377A_1335,iPC815.YPO0321,iSBO_1134.SBO_4064,iSbBS512_1146.SbBS512_E4542,iWFL_1372.ECW_m1275,iYL1228.KPN_02308,iYL1228.KPN_04440 Bacteria 2GM2Y@201174,COG0787@1,COG0787@2 NA|NA|NA E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids MAG.T1.179_00279 1048339.KB913029_gene2786 7.1e-76 291.6 Frankiales nnrD GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0052855,GO:0052856,GO:0052857 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 ko00000,ko01000 Bacteria 2GJHB@201174,4ERGP@85013,COG0062@1,COG0062@2,COG0063@1,COG0063@2 NA|NA|NA G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration MAG.T1.179_00280 1156844.KB891797_gene5833 4.2e-264 917.1 Actinobacteria glmS GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016020,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 iNJ661.Rv3436c,iSB619.SA_RS11245,iYO844.BSU01780 Bacteria 2GKH0@201174,COG0449@1,COG0449@2 NA|NA|NA M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source MAG.T1.179_00281 1120950.KB892784_gene183 5.5e-168 597.4 Propionibacteriales glmM GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006464,GO:0006468,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008966,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019538,GO:0034641,GO:0034654,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0046777,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 R02060 RC00408 ko00000,ko00001,ko01000 iAF987.Gmet_1886,iLJ478.TM0184,iSB619.SA_RS11275,iSBO_1134.SBO_3206 Bacteria 2GN87@201174,4DNFP@85009,COG1109@1,COG1109@2 NA|NA|NA G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate MAG.T1.179_00282 471853.Bcav_3105 3.5e-56 224.6 Actinobacteria rpsI GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02996 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GNDY@201174,COG0103@1,COG0103@2 NA|NA|NA J Belongs to the universal ribosomal protein uS9 family MAG.T1.179_00283 1123321.KB905817_gene5166 1e-61 243.0 Actinobacteria rplM GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0070180,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 ko:K02871 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IFG1@201174,COG0102@1,COG0102@2 NA|NA|NA J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly MAG.T1.179_00284 269800.Tfu_0522 6.3e-25 120.2 Streptosporangiales ybaZ GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0005488,GO:0005515,GO:0019899,GO:0097159,GO:1901363 2.1.1.63 ko:K00567,ko:K07443 ko00000,ko01000,ko03400 Bacteria 2GQMD@201174,4EKN0@85012,COG3695@1,COG3695@2 NA|NA|NA L 6-O-methylguanine DNA methyltransferase, DNA binding domain MAG.T1.179_00285 1122138.AQUZ01000015_gene6722 2e-223 781.9 Propionibacteriales Bacteria 2GMUD@201174,4DNQ6@85009,COG0488@1,COG0488@2 NA|NA|NA S ABC transporter MAG.T1.179_00286 1095767.CAHD01000130_gene1332 8e-80 303.9 Cellulomonadaceae truA GO:0000049,GO:0001522,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 5.4.99.12 ko:K06173 ko00000,ko01000,ko03016 Bacteria 2GJ6C@201174,4F0W6@85016,COG0101@1,COG0101@2 NA|NA|NA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs MAG.T1.179_00287 471853.Bcav_3112 4.2e-53 214.5 Actinobacteria rplQ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 ko:K02879 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IHV2@201174,COG0203@1,COG0203@2 NA|NA|NA J ribosomal protein L17 MAG.T1.179_00288 471852.Tcur_4290 5.8e-151 540.4 Streptosporangiales rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 Bacteria 2GJJ5@201174,4EGUV@85012,COG0202@1,COG0202@2 NA|NA|NA K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates MAG.T1.179_00289 1123320.KB889574_gene5545 1.5e-96 359.0 Actinobacteria rpsD GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0016020,GO:0019222,GO:0019843,GO:0030312,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 ko:K02986 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GIRX@201174,COG0522@1,COG0522@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit MAG.T1.179_00290 1306174.JODP01000006_gene3594 3.9e-61 240.7 Actinobacteria rpsK GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02948 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IFFC@201174,COG0100@1,COG0100@2 NA|NA|NA J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome MAG.T1.179_00291 469371.Tbis_0590 1.1e-52 212.6 Pseudonocardiales rpsM GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02952 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IHPN@201174,4E3FF@85010,COG0099@1,COG0099@2 NA|NA|NA J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits MAG.T1.179_00292 1284679.HMPREF1626_05675 1.4e-13 80.9 Actinobacteria rpmJ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02919 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GWMH@201174,4D6P0@85005,COG0257@1,COG0257@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL36 family MAG.T1.179_00293 269800.Tfu_2622 1.2e-32 145.2 Streptosporangiales infA GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009986,GO:0016020,GO:0030246,GO:0030247,GO:0030312,GO:0040007,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071944,GO:2001065 ko:K02518 ko00000,ko03012 Bacteria 2IQ4B@201174,4EK2Q@85012,COG0361@1,COG0361@2 NA|NA|NA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex MAG.T1.179_00294 530564.Psta_3683 4.4e-135 488.0 Planctomycetes Bacteria 2IX7A@203682,COG0464@1,COG0464@2 NA|NA|NA O growth MAG.T1.179_00295 530564.Psta_3683 8.3e-134 483.8 Planctomycetes Bacteria 2IX7A@203682,COG0464@1,COG0464@2 NA|NA|NA O growth MAG.T1.179_00296 1120950.KB892746_gene3632 3.7e-79 301.6 Propionibacteriales map GO:0000096,GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006464,GO:0006508,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009066,GO:0009987,GO:0010467,GO:0016020,GO:0016151,GO:0016485,GO:0016787,GO:0019538,GO:0019752,GO:0030145,GO:0035551,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044464,GO:0046872,GO:0046914,GO:0050897,GO:0051604,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901605 3.4.11.18 ko:K01265 ko00000,ko01000,ko01002 Bacteria 2GKKB@201174,4DNQ9@85009,COG0024@1,COG0024@2 NA|NA|NA J Methionine aminopeptidase MAG.T1.179_00297 1120941.AUBL01000002_gene2052 1.3e-59 236.1 Actinobacteria adk 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GJ7T@201174,4D4SK@85005,COG0563@1,COG0563@2 NA|NA|NA F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism MAG.T1.179_00298 1504319.GM45_2550 3.4e-159 568.2 unclassified Actinobacteria (class) secY GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5 Bacteria 2GJ26@201174,3UWEW@52018,COG0201@1,COG0201@2 NA|NA|NA U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently MAG.T1.179_00299 1095767.CAHD01000130_gene1318 1.2e-52 212.6 Cellulomonadaceae rplO GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02876 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2II6M@201174,4F16W@85016,COG0200@1,COG0200@2 NA|NA|NA J Binds to the 23S rRNA MAG.T1.179_00300 1121933.AUHH01000003_gene1376 1.2e-14 85.1 Propionibacteriales rpmD GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02907 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GQV0@201174,4DSCE@85009,COG1841@1,COG1841@2 NA|NA|NA J Ribosomal protein L30 MAG.T1.179_00301 105420.BBPO01000022_gene5786 1.6e-66 259.2 Streptacidiphilus rpsE GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990145,GO:1990904 ko:K02988 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GJW8@201174,2NG8M@228398,COG0098@1,COG0098@2 NA|NA|NA J Ribosomal protein S5, C-terminal domain MAG.T1.179_00302 1048339.KB913029_gene2766 1e-39 169.5 Frankiales rplR GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02881 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IKTX@201174,4ESW2@85013,COG0256@1,COG0256@2 NA|NA|NA J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance MAG.T1.179_00303 1133850.SHJG_5812 2.1e-75 288.5 Actinobacteria rplF GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02933 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GK35@201174,COG0097@1,COG0097@2 NA|NA|NA J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center MAG.T1.179_00304 1121385.AQXW01000004_gene2023 3.4e-54 217.6 Dermacoccaceae rpsH GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 ko:K02994 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1ZVXC@145357,2IHQZ@201174,COG0096@1,COG0096@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit MAG.T1.179_00305 446471.Xcel_0640 4.5e-25 119.8 Promicromonosporaceae rpsN GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02954 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IQ8R@201174,4F4WT@85017,COG0199@1,COG0199@2 NA|NA|NA J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site MAG.T1.179_00306 1123251.ATWM01000006_gene2220 7.1e-85 320.1 Intrasporangiaceae rplE GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02931 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GJW7@201174,4FFBJ@85021,COG0094@1,COG0094@2 NA|NA|NA J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits MAG.T1.179_00307 653386.HMPREF0975_01263 1.1e-32 146.0 Actinobacteria rplX GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02895 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IKP2@201174,4D5V7@85005,COG0198@1,COG0198@2 NA|NA|NA J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit MAG.T1.179_00308 1003195.SCAT_3602 7.3e-59 233.0 Actinobacteria rplN GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02874 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IHNX@201174,COG0093@1,COG0093@2 NA|NA|NA J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome MAG.T1.179_00309 1134445.AJJM01000095_gene3679 1.3e-34 152.1 Actinobacteria rpsQ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02961 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IQ68@201174,COG0186@1,COG0186@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA MAG.T1.179_00310 1120950.KB892746_gene3618 1.1e-21 109.0 Propionibacteriales rpmC GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02904 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IQ6V@201174,4DS4S@85009,COG0255@1,COG0255@2 NA|NA|NA J Belongs to the universal ribosomal protein uL29 family MAG.T1.179_00311 1283283.ATXA01000007_gene4009 4.5e-65 253.8 Frankiales rplP GO:0000027,GO:0000049,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02878 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IFEI@201174,4ESFZ@85013,COG0197@1,COG0197@2 NA|NA|NA J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs MAG.T1.179_00312 1121017.AUFG01000021_gene2241 2.6e-90 338.6 Intrasporangiaceae rpsC GO:0000028,GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02982 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GKF1@201174,4FF4N@85021,COG0092@1,COG0092@2 NA|NA|NA J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation MAG.T1.179_00313 1123322.KB904651_gene461 7.6e-45 186.4 Actinobacteria rplV GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042788,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02890 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IM3J@201174,COG0091@1,COG0091@2 NA|NA|NA J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome MAG.T1.179_00314 1032480.MLP_11020 2.5e-43 181.0 Propionibacteriales rpsS GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02965 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IKMS@201174,4DR2Q@85009,COG0185@1,COG0185@2 NA|NA|NA J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA MAG.T1.179_00315 1095772.CAHH01000006_gene2255 4.4e-144 517.3 Actinobacteria rplB GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02886 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GK7R@201174,COG0090@1,COG0090@2 NA|NA|NA J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity MAG.T1.179_00316 1048339.KB913029_gene2752 4.6e-35 153.7 Frankiales rplW GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02892 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IQ7V@201174,4ET1Y@85013,COG0089@1,COG0089@2 NA|NA|NA J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome MAG.T1.179_00317 1048339.KB913029_gene2751 1.1e-82 313.5 Frankiales rplD GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02926 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GJYJ@201174,4ES9Y@85013,COG0088@1,COG0088@2 NA|NA|NA J Forms part of the polypeptide exit tunnel MAG.T1.179_00318 1210046.B277_02376 3.2e-86 324.7 Intrasporangiaceae rplC GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010604,GO:0010628,GO:0015934,GO:0016020,GO:0016043,GO:0019219,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0031323,GO:0031325,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000232,GO:2000234 ko:K02906 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GJXT@201174,4FECG@85021,COG0087@1,COG0087@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit MAG.T1.179_00319 397278.JOJN01000002_gene234 4.7e-51 206.8 Propionibacteriales rpsJ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02946 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IHRA@201174,4DQJR@85009,COG0051@1,COG0051@2 NA|NA|NA J Involved in the binding of tRNA to the ribosomes MAG.T1.179_00320 1122609.AUGT01000009_gene3386 1e-202 712.6 Propionibacteriales tuf GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 ko:K02358 ko00000,ko03012,ko03029,ko04147 Bacteria 2GK4T@201174,4DP42@85009,COG0050@1,COG0050@2 NA|NA|NA J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis MAG.T1.179_00321 1120936.KB907214_gene4465 1.3e-169 602.4 Streptosporangiales fusA GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0030312,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02355 ko00000,ko03012,ko03029 Bacteria 2GKB3@201174,4EH47@85012,COG0480@1,COG0480@2 NA|NA|NA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome MAG.T1.179_00322 1048339.KB913029_gene2939 1.1e-279 969.5 Frankiales GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K09118 ko00000 Bacteria 2GMP3@201174,4ERVJ@85013,COG1615@1,COG1615@2 NA|NA|NA S Uncharacterised protein family (UPF0182) MAG.T1.179_00323 1283299.AUKG01000001_gene3535 2.6e-38 166.0 Rubrobacteria apbE 2.7.1.180 ko:K03734 ko00000,ko01000 Bacteria 2GN6F@201174,4CSHI@84995,COG1477@1,COG1477@2 NA|NA|NA H ApbE family MAG.T1.179_00324 47716.JOFH01000006_gene1658 2.1e-35 155.6 Actinobacteria Bacteria 2DA1Q@1,2GKR3@201174,32TUF@2 NA|NA|NA MAG.T1.179_00325 2002.JOEQ01000007_gene1821 2.5e-68 266.2 Streptosporangiales lon ko:K07177 ko02024,map02024 ko00000,ko00001,ko01002 Bacteria 2GJDD@201174,4EFR5@85012,COG3480@1,COG3480@2 NA|NA|NA T Lon protease (S16) C-terminal proteolytic domain MAG.T1.179_00326 58123.JOFJ01000003_gene2296 7.9e-117 427.6 Streptosporangiales Bacteria 2GJ9K@201174,4EFYY@85012,COG5282@1,COG5282@2 NA|NA|NA S Zincin-like metallopeptidase MAG.T1.179_00327 1394178.AWOO02000039_gene8628 1.4e-30 139.8 Streptosporangiales nudJ ko:K12152 ko00000,ko01000 Bacteria 2GU6D@201174,4EIW9@85012,COG0494@1,COG0494@2 NA|NA|NA L NUDIX domain MAG.T1.179_00328 479433.Caci_7935 7.7e-70 270.8 Actinobacteria 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 Bacteria 2I7QX@201174,COG1024@1,COG1024@2 NA|NA|NA I Belongs to the enoyl-CoA hydratase isomerase family MAG.T1.179_00329 1504319.GM45_1925 1.6e-15 87.8 Actinobacteria Bacteria 2E479@1,2GQXY@201174,32Z35@2 NA|NA|NA MAG.T1.179_00330 1048339.KB913029_gene2928 5.5e-157 560.8 Frankiales Bacteria 2GJQ6@201174,4ES31@85013,COG0661@1,COG0661@2 NA|NA|NA S PFAM ABC-1 domain protein MAG.T1.179_00331 1385521.N803_02695 4e-181 641.7 Intrasporangiaceae uvrD 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 2GKRW@201174,4FFFK@85021,COG0210@1,COG0210@2 NA|NA|NA L DNA helicase MAG.T1.179_00332 436229.JOEH01000016_gene7218 1.7e-57 229.9 Streptacidiphilus nudC 3.6.1.22 ko:K03426 ko00760,ko01100,ko04146,map00760,map01100,map04146 R00103,R03004,R11104 RC00002 ko00000,ko00001,ko01000 Bacteria 2GJZY@201174,2NF9K@228398,COG2816@1,COG2816@2 NA|NA|NA L NADH pyrophosphatase-like rudimentary NUDIX domain MAG.T1.179_00333 1123320.KB889672_gene3701 8.6e-57 227.6 Actinobacteria Bacteria 2GP3V@201174,COG3568@1,COG3568@2 NA|NA|NA L endonuclease exonuclease phosphatase MAG.T1.179_00334 1894.JOER01000030_gene507 1.3e-207 730.3 Actinobacteria uvrD2 3.6.4.12 ko:K03657,ko:K07465 ko03420,ko03430,map03420,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 2GM2E@201174,COG0210@1,COG0210@2,COG2887@1,COG2887@2 NA|NA|NA L Belongs to the helicase family. UvrD subfamily MAG.T1.179_00335 73044.JNXP01000009_gene2772 1.9e-193 683.3 Actinobacteria uvrD 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 2GJD0@201174,COG0210@1,COG0210@2,COG2887@1,COG2887@2 NA|NA|NA L Belongs to the helicase family. UvrD subfamily MAG.T1.179_00336 28444.JODQ01000008_gene1197 2.3e-140 506.5 Streptosporangiales Bacteria 2GMAV@201174,4EHD3@85012,COG0392@1,COG0392@2 NA|NA|NA I Lysylphosphatidylglycerol synthase TM region MAG.T1.179_00337 1298863.AUEP01000002_gene1395 3.5e-19 102.1 Propionibacteriales Bacteria 29S49@1,2GWCT@201174,30D8R@2,4DVAR@85009 NA|NA|NA S TadE-like protein MAG.T1.179_00338 1298863.AUEP01000002_gene1394 4.6e-88 332.4 Propionibacteriales Bacteria 2IAR7@201174,4DTBY@85009,COG4655@1,COG4655@2 NA|NA|NA S Putative Flp pilus-assembly TadE/G-like MAG.T1.179_00339 1298863.AUEP01000002_gene1395 3.4e-19 102.1 Propionibacteriales Bacteria 29S49@1,2GWCT@201174,30D8R@2,4DVAR@85009 NA|NA|NA S TadE-like protein MAG.T1.179_00340 196162.Noca_3114 6.2e-33 147.9 Propionibacteriales cpaB ko:K02279 ko00000,ko02035,ko02044 Bacteria 2INHS@201174,4DSV2@85009,COG3745@1,COG3745@2 NA|NA|NA U Flp pilus assembly protein RcpC/CpaB MAG.T1.179_00341 1380370.JIBA01000003_gene2731 1.5e-78 300.1 Intrasporangiaceae flpE ko:K02282 ko00000,ko02035,ko02044 Bacteria 2GNHI@201174,4FG1C@85021,COG4963@1,COG4963@2 NA|NA|NA D chromosome partitioning MAG.T1.179_00343 397278.JOJN01000004_gene1179 1.6e-83 317.4 Propionibacteriales ko:K12510 ko00000,ko02044 Bacteria 2H577@201174,4DQ0A@85009,COG2304@1,COG2304@2,COG4965@1,COG4965@2 NA|NA|NA U Type II secretion system (T2SS), protein F MAG.T1.179_00344 1122609.AUGT01000012_gene4249 6.4e-67 261.2 Propionibacteriales ko:K12511 ko00000,ko02044 Bacteria 2GK7B@201174,4DR34@85009,COG2064@1,COG2064@2 NA|NA|NA NU Type II secretion system MAG.T1.179_00347 367299.JOEE01000003_gene2964 7.9e-32 145.2 Intrasporangiaceae Bacteria 2ICX6@201174,4FF5W@85021,COG1287@1,COG1287@2 NA|NA|NA S oligosaccharyl transferase activity MAG.T1.179_00348 471852.Tcur_2117 9e-34 151.4 Streptosporangiales Bacteria 2GN1J@201174,4EJA0@85012,COG5650@1,COG5650@2 NA|NA|NA S Glycosyltransferase family 87 MAG.T1.179_00349 2074.JNYD01000016_gene4254 3.9e-21 109.4 Pseudonocardiales ko:K13671 ko00000,ko01000,ko01003 GT87 Bacteria 2GJBC@201174,4E0FQ@85010,COG5650@1,COG5650@2 NA|NA|NA S Glycosyltransferase family 87 MAG.T1.179_00350 211114.JOEF01000026_gene262 1.1e-20 107.8 Pseudonocardiales ko:K13671 ko00000,ko01000,ko01003 GT87 Bacteria 2GJBC@201174,4DZJI@85010,COG5650@1,COG5650@2 NA|NA|NA S Glycosyltransferase family 87 MAG.T1.179_00351 479432.Sros_8386 1.1e-65 256.9 Streptosporangiales Bacteria 2GM96@201174,4EI1R@85012,COG2267@1,COG2267@2 NA|NA|NA I Serine aminopeptidase, S33 MAG.T1.179_00352 285535.JOEY01000001_gene5229 5e-60 237.7 Actinobacteria Bacteria 2GVM5@201174,COG1309@1,COG1309@2 NA|NA|NA K transcriptional regulator MAG.T1.179_00353 477641.MODMU_4652 2.5e-14 84.3 Frankiales Bacteria 2E3M2@1,2GQQW@201174,32YJA@2,4ETF4@85013 NA|NA|NA S Protein of unknown function (DUF3107) MAG.T1.179_00354 452652.KSE_48740 2.5e-60 238.8 Kitasatospora GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0071771 1.16.3.1,4.1.99.5 ko:K03594,ko:K14331 ko00860,map00860 R00078 RC02758 ko00000,ko00001,ko01000 Bacteria 2I2E1@201174,2M2BB@2063,COG1633@1,COG1633@2 NA|NA|NA S tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like MAG.T1.179_00355 1155714.KB891987_gene2874 6.5e-170 604.0 Actinobacteria deaD 3.6.4.13 ko:K05592,ko:K11927 ko03018,map03018 ko00000,ko00001,ko01000,ko03009,ko03019 Bacteria 2GIUR@201174,COG0513@1,COG0513@2 NA|NA|NA L Belongs to the DEAD box helicase family MAG.T1.179_00356 1048339.KB913029_gene2907 3.7e-13 80.9 Frankiales Bacteria 2C4RB@1,2HAZK@201174,2ZVRN@2,4EWZ7@85013 NA|NA|NA MAG.T1.179_00357 1048339.KB913029_gene2906 4.1e-99 367.9 Frankiales soj ko:K03496 ko00000,ko03036,ko04812 Bacteria 2GNEQ@201174,4EUFG@85013,COG1192@1,COG1192@2 NA|NA|NA D Cellulose biosynthesis protein BcsQ MAG.T1.179_00358 1449346.JQMO01000003_gene3193 4.6e-43 181.8 Kitasatospora Bacteria 2GKPK@201174,2M0AS@2063,COG2267@1,COG2267@2 NA|NA|NA I Serine aminopeptidase, S33 MAG.T1.179_00359 1906.SFRA_14425 2.5e-18 98.6 Actinobacteria prpE2 Bacteria 2GK8P@201174,COG0642@1,COG0642@2,COG2208@1,COG2208@2 NA|NA|NA T protein phosphatase 2C domain protein MAG.T1.179_00360 397278.JOJN01000006_gene1006 2.9e-50 206.1 Propionibacteriales 3.1.1.29 ko:K01056 ko00000,ko01000,ko03012 Bacteria 2HVQW@201174,4DQVN@85009,COG4427@1,COG4427@2 NA|NA|NA S Uncharacterized protein conserved in bacteria (DUF2332) MAG.T1.179_00361 1288083.AUKR01000008_gene1615 5.7e-177 627.1 Actinobacteria Bacteria 2GIX8@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase MAG.T1.179_00362 1048339.KB913029_gene2897 2.2e-147 528.5 Frankiales mcl1 4.1.3.24,4.1.3.25,4.1.3.34,5.4.99.63 ko:K01644,ko:K08691,ko:K14447,ko:K18292 ko00630,ko00660,ko00680,ko00720,ko01100,ko01120,ko01200,ko02020,map00630,map00660,map00680,map00720,map01100,map01120,map01200,map02020 M00346,M00373,M00376 R00237,R00362,R00473,R00934,R09292 RC00067,RC00307,RC00308,RC00311,RC00407,RC00502,RC01118,RC01205,RC02835 ko00000,ko00001,ko00002,ko01000 Bacteria 2GK5J@201174,4ESAE@85013,COG0697@1,COG0697@2,COG2301@1,COG2301@2 NA|NA|NA G Belongs to the HpcH HpaI aldolase family MAG.T1.179_00363 1283283.ATXA01000005_gene2174 3.3e-68 265.4 Frankiales Bacteria 2I198@201174,4ESMN@85013,COG0697@1,COG0697@2 NA|NA|NA EG EamA-like transporter family MAG.T1.179_00364 351607.Acel_1818 8.9e-109 400.6 Frankiales mgtE Bacteria 2GMMK@201174,4ERJN@85013,COG2239@1,COG2239@2 NA|NA|NA P CBS domain MAG.T1.179_00365 253839.SSNG_04680 7.3e-52 210.3 Actinobacteria Bacteria 2GJRV@201174,COG4420@1,COG4420@2 NA|NA|NA S membrane MAG.T1.179_00366 743718.Isova_1998 4e-278 964.1 Promicromonosporaceae glgP GO:0000272,GO:0003674,GO:0003824,GO:0004645,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0005977,GO:0005980,GO:0006073,GO:0006091,GO:0006112,GO:0008144,GO:0008150,GO:0008152,GO:0008184,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0015980,GO:0016052,GO:0016740,GO:0016757,GO:0016758,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901575 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 R02111 ko00000,ko00001,ko01000 GT35 Bacteria 2GIVZ@201174,4F4ZX@85017,COG0058@1,COG0058@2 NA|NA|NA G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties MAG.T1.179_00367 1463856.JOHY01000039_gene1645 2e-139 502.3 Actinobacteria mrp GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 ko:K03593 ko00000,ko03029,ko03036 Bacteria 2GJUZ@201174,COG0489@1,COG0489@2 NA|NA|NA D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP MAG.T1.179_00368 269800.Tfu_0381 8.5e-08 63.9 Streptosporangiales tatB GO:0008150,GO:0040007 ko:K03116,ko:K03117 ko03060,ko03070,map03060,map03070 M00336 ko00000,ko00001,ko00002,ko02044 2.A.64 Bacteria 2IR0U@201174,4EKBD@85012,COG1826@1,COG1826@2 NA|NA|NA U mttA/Hcf106 family MAG.T1.179_00369 1223523.H340_31413 4.2e-89 335.5 Actinobacteria 3.4.21.107 ko:K04771,ko:K08372 ko01503,ko02020,map01503,map02020 M00728 ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 Bacteria 2GJ96@201174,COG0265@1,COG0265@2 NA|NA|NA O Peptidase s1 and s6 chymotrypsin hap MAG.T1.179_00370 1283287.KB822583_gene2793 1.3e-66 259.6 Propionibacteriales safC GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 Bacteria 2GPEV@201174,4DNEI@85009,COG4122@1,COG4122@2 NA|NA|NA S O-methyltransferase MAG.T1.179_00371 1394178.AWOO02000057_gene737 1e-98 367.5 Streptosporangiales 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 Bacteria 2GJRB@201174,4EFVT@85012,COG0260@1,COG0260@2 NA|NA|NA E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides MAG.T1.179_00372 561175.KB894095_gene2192 4.3e-19 99.8 Streptosporangiales Bacteria 2E39N@1,2GQFF@201174,32Y97@2,4EKN2@85012 NA|NA|NA S Protein of unknown function (DUF3117) MAG.T1.179_00373 1380393.JHVP01000007_gene4322 6.6e-25 120.6 Frankiales Bacteria 2II8Y@201174,4ETJ6@85013,COG3427@1,COG3427@2 NA|NA|NA S Polyketide cyclase / dehydrase and lipid transport MAG.T1.179_00374 479433.Caci_7945 1.3e-07 62.4 Bacteria Bacteria COG3599@1,COG3599@2 NA|NA|NA D regulation of cell shape MAG.T1.179_00375 1343740.M271_18215 1.9e-105 389.0 Actinobacteria folP2 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJNI@201174,COG0294@1,COG0294@2 NA|NA|NA H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives MAG.T1.179_00376 1229203.KI301992_gene1914 9.4e-96 356.7 unclassified Actinobacteria (class) fmt2 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 Bacteria 2GKJH@201174,3UXFN@52018,COG1611@1,COG1611@2 NA|NA|NA S Possible lysine decarboxylase MAG.T1.179_00377 298654.FraEuI1c_2189 2.5e-55 221.9 Frankiales yceI Bacteria 2GJUB@201174,4ESN7@85013,COG2353@1,COG2353@2 NA|NA|NA S Belongs to the UPF0312 family MAG.T1.179_00378 1048339.KB913029_gene25 9.4e-123 446.8 Frankiales dapE GO:0008150,GO:0040007 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 Bacteria 2GK09@201174,4ES00@85013,COG0624@1,COG0624@2 NA|NA|NA E Succinyl-diaminopimelate desuccinylase MAG.T1.179_00379 1210045.ALNP01000010_gene1189 1.1e-103 383.3 Actinobacteria dapD GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008666,GO:0016020,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016749,GO:0030312,GO:0031402,GO:0031420,GO:0040007,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0048037,GO:0050662,GO:0071944 2.3.1.117 ko:K00674 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04365 RC00004,RC01136 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1201c Bacteria 2GIZ9@201174,COG2171@1,COG2171@2 NA|NA|NA E Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA MAG.T1.179_00381 1122611.KB903974_gene2937 6.8e-36 157.1 Streptosporangiales Bacteria 2GMPH@201174,4EJKB@85012,COG1853@1,COG1853@2 NA|NA|NA S Flavin reductase like domain MAG.T1.179_00382 1120950.KB892823_gene520 1.3e-94 354.0 Propionibacteriales vanW Bacteria 2GISH@201174,4DN8K@85009,COG2720@1,COG2720@2 NA|NA|NA V Putative peptidoglycan binding domain MAG.T1.179_00383 1184609.KILIM_030_00650 7.1e-50 203.0 Dermatophilaceae fdxA ko:K05524 ko00000 Bacteria 2IKVN@201174,4F715@85018,COG1146@1,COG1146@2 NA|NA|NA C 4Fe-4S binding domain MAG.T1.179_00384 1246995.AFR_38740 3.3e-133 481.5 Micromonosporales dapC Bacteria 2GJMI@201174,4DB04@85008,COG0436@1,COG0436@2 NA|NA|NA E Aminotransferase MAG.T1.179_00385 253839.SSNG_00156 4.2e-70 271.2 Actinobacteria Bacteria 2DKWQ@1,2I3CS@201174,30MQE@2 NA|NA|NA S Glyoxalase-like domain MAG.T1.179_00386 1386089.N865_11735 8.1e-182 643.3 Intrasporangiaceae gltA 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ7E@201174,4FEQ1@85021,COG0372@1,COG0372@2 NA|NA|NA C Belongs to the citrate synthase family MAG.T1.179_00387 266940.Krad_1135 2.7e-197 695.3 Actinobacteria ftsH ko:K03798 M00742 ko00000,ko00002,ko01000,ko01002,ko03110 Bacteria 2I9X7@201174,COG0465@1,COG0465@2 NA|NA|NA O Belongs to the AAA ATPase family MAG.T1.179_00388 1122175.ATXU01000007_gene136 5e-75 287.7 Microbacteriaceae ppgK 2.7.1.2,2.7.1.63 ko:K00845,ko:K00886 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786,R02187,R02189 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJA0@201174,4FMFB@85023,COG1940@1,COG1940@2 NA|NA|NA GK ROK family MAG.T1.179_00389 1449353.JQMQ01000005_gene2404 1.1e-97 363.2 Streptacidiphilus mshB 3.5.1.103 ko:K15525 ko00000,ko01000 Bacteria 2GKUM@201174,2NET5@228398,COG2120@1,COG2120@2 NA|NA|NA S GlcNAc-PI de-N-acetylase MAG.T1.179_00390 1048339.KB913029_gene2175 4e-27 129.0 Frankiales bldKE ko:K02032,ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 2H4BW@201174,4EUB4@85013,COG4608@1,COG4608@2 NA|NA|NA P Oligopeptide/dipeptide transporter, C-terminal region MAG.T1.179_00391 66377.JOBH01000017_gene2936 1e-121 443.4 Actinobacteria ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 2H4BW@201174,COG4608@1,COG4608@2 NA|NA|NA E Belongs to the ABC transporter superfamily MAG.T1.179_00392 1463820.JOGW01000003_gene7196 5.7e-114 417.5 Actinobacteria dppD ko:K02031,ko:K02032,ko:K15583 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 2GIXV@201174,COG0444@1,COG0444@2 NA|NA|NA EP Belongs to the ABC transporter superfamily MAG.T1.179_00393 1123320.KB889719_gene7333 4.6e-73 281.6 Actinobacteria oppC ko:K02034,ko:K15582 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 2GJ9E@201174,COG1173@1,COG1173@2 NA|NA|NA EP PFAM binding-protein-dependent transport systems inner membrane component MAG.T1.179_00394 1385520.N802_16405 5.5e-87 327.8 Intrasporangiaceae ko:K02033,ko:K13890,ko:K15581 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00348,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.11,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 2GJ2C@201174,4FEQC@85021,COG0601@1,COG0601@2 NA|NA|NA U ABC transporter (Permease) MAG.T1.179_00395 1122182.KB903813_gene2505 5.2e-80 305.4 Micromonosporales ko:K02035,ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 2GIUH@201174,4DBF2@85008,COG4166@1,COG4166@2 NA|NA|NA E extracellular solute-binding protein MAG.T1.179_00396 106370.Francci3_3865 1.4e-286 991.9 Frankiales typA GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840 ko:K06207 ko00000 Bacteria 2GJUJ@201174,4ES8A@85013,COG1217@1,COG1217@2 NA|NA|NA T GTP-binding protein TypA MAG.T1.179_00397 1120965.AUBV01000015_gene1112 6.5e-08 65.1 Bacteroidetes Bacteria 4NMM2@976,COG2120@1,COG2120@2 NA|NA|NA S GlcNAc-PI de-N-acetylase MAG.T1.179_00398 710685.MycrhN_1550 1.9e-222 778.9 Mycobacteriaceae pepO 3.4.24.11,3.4.24.71 ko:K01389,ko:K01415,ko:K07386 ko04614,ko04640,ko04974,ko05010,map04614,map04640,map04974,map05010 ko00000,ko00001,ko01000,ko01002,ko04090,ko04147 Bacteria 2331P@1762,2GNJY@201174,COG3590@1,COG3590@2 NA|NA|NA O peptidase MAG.T1.179_00399 1156844.KB891814_gene6810 3.7e-42 178.3 Actinobacteria alkD Bacteria 2GNQD@201174,COG4912@1,COG4912@2 NA|NA|NA L DNA alkylation repair MAG.T1.179_00400 1148.1652140 1.1e-174 619.8 Synechocystis gadB 4.1.1.15 ko:K01580 ko00250,ko00410,ko00430,ko00650,ko01100,ko01110,ko01120,ko02024,ko04727,ko04940,map00250,map00410,map00430,map00650,map01100,map01110,map01120,map02024,map04727,map04940 M00027 R00261,R00489,R01682,R02466 RC00299 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv3432c Bacteria 1G47D@1117,1H682@1142,COG0076@1,COG0076@2 NA|NA|NA E Pyridoxal-dependent decarboxylase conserved domain MAG.T1.179_00401 1298863.AUEP01000001_gene1023 1.9e-99 369.0 Propionibacteriales Bacteria 2I8NG@201174,30Y0T@2,4DW1P@85009,arCOG10607@1 NA|NA|NA MAG.T1.179_00402 1121920.AUAU01000018_gene1775 6.9e-17 94.0 Acidobacteria Bacteria 3Y4HW@57723,COG2318@1,COG2318@2 NA|NA|NA S Mycothiol maleylpyruvate isomerase N-terminal domain MAG.T1.179_00403 404589.Anae109_3092 6.7e-17 95.9 Proteobacteria Bacteria 1N29G@1224,COG3568@1,COG3568@2 NA|NA|NA S Endonuclease/Exonuclease/phosphatase family MAG.T1.179_00405 452652.KSE_07440 1.2e-25 124.4 Actinobacteria 2.1.1.107 ko:K02303,ko:K22010 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121,M00839 R03194 RC00003,RC00871 ko00000,ko00001,ko00002,ko01000,ko02022 Bacteria 2GKG3@201174,COG2203@1,COG2203@2,COG2208@1,COG2208@2,COG3707@1,COG3707@2 NA|NA|NA KT phosphatase MAG.T1.179_00407 1123020.AUIE01000023_gene5023 9.2e-10 69.3 Bacteria Bacteria COG0236@1,COG0236@2 NA|NA|NA IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis MAG.T1.179_00408 405948.SACE_2405 8.1e-93 347.8 Pseudonocardiales aceF 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2GN5J@201174,4E8QP@85010,COG0508@1,COG0508@2 NA|NA|NA C 2-oxoacid dehydrogenases acyltransferase (catalytic domain) MAG.T1.179_00409 1449044.JMLE01000025_gene3354 1.3e-134 486.1 Micrococcaceae pdhA 1.2.4.1,1.2.4.4 ko:K00162,ko:K11381 ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00036,M00307 R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1WAY5@1268,2GKFE@201174,COG0022@1,COG0022@2 NA|NA|NA C Transketolase, C-terminal domain MAG.T1.179_00410 290399.Arth_0510 3.5e-122 444.9 Micrococcaceae pdhA 1.2.4.1,1.2.4.4 ko:K00161,ko:K00162,ko:K11381,ko:K21416 ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00036,M00307 R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1WAV4@1268,2IBRC@201174,COG1071@1,COG1071@2 NA|NA|NA C Dehydrogenase E1 component MAG.T1.179_00411 467200.ACFA01000086_gene1346 1.4e-222 779.2 Actinobacteria acsA 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 2GNE8@201174,COG0365@1,COG0365@2 NA|NA|NA I synthetase MAG.T1.179_00412 1123065.ATWL01000009_gene974 4.8e-50 204.1 Actinobacteria 3.6.1.55 ko:K03574 ko00000,ko01000,ko03400 Bacteria 2IKKB@201174,COG1051@1,COG1051@2 NA|NA|NA F Nudix hydrolase MAG.T1.179_00414 103733.JNYO01000008_gene5422 1.4e-46 193.7 Pseudonocardiales Bacteria 2GKAY@201174,4E36B@85010,COG5012@1,COG5012@2 NA|NA|NA S cobalamin binding protein MAG.T1.179_00415 479435.Kfla_5843 3.5e-76 291.2 Propionibacteriales nth 4.2.99.18 ko:K07457,ko:K10773 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 2GNE5@201174,4DQDJ@85009,COG0177@1,COG0177@2 NA|NA|NA L HhH-GPD superfamily base excision DNA repair protein MAG.T1.179_00417 1121106.JQKB01000013_gene5441 1.2e-07 63.9 Alphaproteobacteria Bacteria 1QW7K@1224,2U79M@28211,COG2197@1,COG2197@2 NA|NA|NA K helix_turn_helix, Lux Regulon MAG.T1.179_00418 1280946.HY29_18285 1.6e-36 160.2 Alphaproteobacteria Bacteria 1NPD3@1224,2UX3E@28211,COG2850@1,COG2850@2 NA|NA|NA S Cupin superfamily protein MAG.T1.179_00419 1231391.AMZF01000003_gene3115 2.6e-50 205.7 Alcaligenaceae Bacteria 1N3A2@1224,2W95G@28216,3T7RQ@506,COG1028@1,COG1028@2 NA|NA|NA IQ KR domain MAG.T1.179_00420 1352941.M877_37700 1e-30 141.4 Actinobacteria sagD ko:K09136 ko00000,ko03009 Bacteria 2GKBS@201174,COG1944@1,COG1944@2 NA|NA|NA S YcaO cyclodehydratase, ATP-ad Mg2+-binding MAG.T1.179_00422 1278073.MYSTI_04797 4.8e-63 248.8 Deltaproteobacteria hemN GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 Bacteria 1MU76@1224,2WIM5@28221,42NGU@68525,COG0635@1,COG0635@2 NA|NA|NA H Involved in the biosynthesis of porphyrin-containing compound MAG.T1.179_00423 318586.Pden_4195 8.2e-32 144.4 Alphaproteobacteria sagB Bacteria 1PUI1@1224,2U13C@28211,COG0778@1,COG0778@2 NA|NA|NA C Nitroreductase family MAG.T1.179_00426 1380386.JIAW01000001_gene4637 2.5e-105 389.0 Mycobacteriaceae tdt Bacteria 2357X@1762,2GKPA@201174,COG1275@1,COG1275@2 NA|NA|NA P C4-dicarboxylate transporter malic acid transport protein MAG.T1.179_00427 1169161.KB897741_gene1993 6.2e-90 337.8 Actinobacteria pstS GO:0002682,GO:0002683,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009607,GO:0009987,GO:0009991,GO:0015698,GO:0016020,GO:0016036,GO:0030312,GO:0031347,GO:0031348,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0035821,GO:0040007,GO:0042594,GO:0043207,GO:0044003,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044413,GO:0044414,GO:0044419,GO:0044464,GO:0045088,GO:0045824,GO:0048519,GO:0048583,GO:0048585,GO:0050776,GO:0050777,GO:0050789,GO:0050896,GO:0051179,GO:0051234,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051817,GO:0051832,GO:0051833,GO:0052031,GO:0052037,GO:0052167,GO:0052170,GO:0052173,GO:0052200,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0065007,GO:0071496,GO:0071944,GO:0075136,GO:0080134 ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 ko00000,ko00001,ko00002,ko02000 3.A.1.7 Bacteria 2GJXD@201174,COG0226@1,COG0226@2 NA|NA|NA P Part of the ABC transporter complex PstSACB involved in phosphate import MAG.T1.179_00428 1184607.AUCHE_08_00700 2.5e-60 238.8 Dermatophilaceae Bacteria 2GKFS@201174,4F6SG@85018,COG0745@1,COG0745@2 NA|NA|NA K Transcriptional regulatory protein, C terminal MAG.T1.179_00430 1081644.IMCC13023_04080 8.6e-196 690.3 Microbacteriaceae Bacteria 2I7FH@201174,4FRRZ@85023,COG0457@1,COG0457@2 NA|NA|NA S Tetratricopeptide repeat MAG.T1.179_00431 1081644.IMCC13023_04070 6.1e-47 194.5 Actinobacteria Bacteria 2B8JV@1,2H60Z@201174,321V3@2 NA|NA|NA MAG.T1.179_00434 477641.MODMU_4618 3.3e-47 194.9 Frankiales bar 2.3.1.183 ko:K03823 ko00440,ko01130,map00440,map01130 R08871,R08938 RC00004,RC00064 ko00000,ko00001,ko01000 Bacteria 2IHSY@201174,4EVJN@85013,COG1247@1,COG1247@2 NA|NA|NA M Acetyltransferase (GNAT) domain MAG.T1.179_00435 471852.Tcur_0810 9.6e-252 875.9 Streptosporangiales ercc3 3.6.4.12 ko:K10843 ko03022,ko03420,map03022,map03420 M00290 ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 Bacteria 2GIR9@201174,4EHX6@85012,COG1061@1,COG1061@2 NA|NA|NA L ERCC3/RAD25/XPB C-terminal helicase MAG.T1.179_00436 1003195.SCAT_2429 5.2e-107 395.6 Actinobacteria M1-1077 Bacteria 2GURQ@201174,COG2378@1,COG2378@2 NA|NA|NA K Helicase conserved C-terminal domain MAG.T1.179_00438 743718.Isova_2592 7.1e-41 173.3 Promicromonosporaceae cspB ko:K03704 ko00000,ko03000 Bacteria 2IKXN@201174,4F4QM@85017,COG1278@1,COG1278@2 NA|NA|NA K Cold shock protein domain MAG.T1.179_00439 1206101.AZXC01000007_gene2428 6.7e-09 67.4 Actinobacteria Bacteria 2F261@1,2IFIE@201174,33V4D@2 NA|NA|NA MAG.T1.179_00440 1048339.KB913029_gene2148 2.2e-62 245.7 Frankiales Bacteria 28NWB@1,2GJ74@201174,2ZBU7@2,4ESJV@85013 NA|NA|NA S Protein of unknown function (DUF3027) MAG.T1.179_00441 656024.FsymDg_0268 4.8e-07 60.5 Frankiales Bacteria 2ETMT@1,2HU3T@201174,33M5J@2,4EWV2@85013 NA|NA|NA S Protein of unknown function (DUF2530) MAG.T1.179_00442 1123320.KB889723_gene7524 2.9e-46 192.6 Actinobacteria Bacteria 2GNAZ@201174,COG3386@1,COG3386@2 NA|NA|NA G PFAM SMP-30 Gluconolaconase MAG.T1.179_00443 1150864.MILUP08_42574 8.6e-43 179.9 Micromonosporales Bacteria 2HR7I@201174,4DFE0@85008,COG2315@1,COG2315@2 NA|NA|NA S YjbR MAG.T1.179_00444 644283.Micau_0514 8.6e-151 540.0 Micromonosporales serC GO:0001505,GO:0003674,GO:0003824,GO:0004760,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005886,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006807,GO:0008150,GO:0008152,GO:0008453,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0019265,GO:0019752,GO:0040007,GO:0042133,GO:0042136,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0065007,GO:0065008,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 2GKYK@201174,4D8WE@85008,COG1932@1,COG1932@2 NA|NA|NA EH Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine MAG.T1.179_00445 285535.JOEY01000002_gene4814 9.4e-174 616.3 Actinobacteria citA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2GKST@201174,COG0372@1,COG0372@2 NA|NA|NA C Belongs to the citrate synthase family MAG.T1.179_00446 1449347.JQLN01000005_gene4049 3.1e-55 221.9 Kitasatospora pdxH 1.4.3.5 ko:K00275 ko00750,ko01100,ko01120,map00750,map01100,map01120 M00124 R00277,R00278,R01710,R01711 RC00048,RC00116 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJCR@201174,2M25F@2063,COG0259@1,COG0259@2 NA|NA|NA H Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) MAG.T1.179_00447 765420.OSCT_1250 1.3e-21 110.2 Chloroflexia ko:K08981 ko00000 Bacteria 2G70V@200795,375QN@32061,COG3428@1,COG3428@2 NA|NA|NA S PFAM membrane-flanked domain MAG.T1.179_00448 469383.Cwoe_0732 5.3e-74 284.6 Actinobacteria ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2I2DK@201174,COG4152@1,COG4152@2 NA|NA|NA S ABC transporter MAG.T1.179_00449 543632.JOJL01000027_gene2595 1.1e-39 171.0 Micromonosporales ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2I9MY@201174,4DCFI@85008,COG1668@1,COG1668@2 NA|NA|NA CP ABC-2 family transporter protein MAG.T1.179_00450 287986.DV20_43550 2.9e-147 528.1 Pseudonocardiales Bacteria 2H0AR@201174,4E90A@85010,COG0627@1,COG0627@2 NA|NA|NA S Putative esterase MAG.T1.179_00453 1068980.ARVW01000001_gene8375 1.6e-52 213.0 Pseudonocardiales parA ko:K03496 ko00000,ko03036,ko04812 Bacteria 2H4UC@201174,4DZB6@85010,COG1192@1,COG1192@2 NA|NA|NA D involved in chromosome partitioning MAG.T1.179_00454 1123320.KB889746_gene8006 2.4e-136 492.3 Actinobacteria phrB GO:0000003,GO:0000166,GO:0000719,GO:0001101,GO:0002252,GO:0002376,GO:0003006,GO:0003674,GO:0003824,GO:0003904,GO:0003913,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005773,GO:0006139,GO:0006259,GO:0006281,GO:0006290,GO:0006325,GO:0006338,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006873,GO:0006874,GO:0006875,GO:0006950,GO:0006952,GO:0006974,GO:0006996,GO:0007154,GO:0007165,GO:0007275,GO:0007623,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009314,GO:0009414,GO:0009415,GO:0009416,GO:0009605,GO:0009606,GO:0009607,GO:0009615,GO:0009628,GO:0009637,GO:0009638,GO:0009642,GO:0009645,GO:0009646,GO:0009648,GO:0009719,GO:0009725,GO:0009785,GO:0009791,GO:0009881,GO:0009882,GO:0009888,GO:0009893,GO:0009909,GO:0009911,GO:0009987,GO:0010033,GO:0010035,GO:0010073,GO:0010075,GO:0010118,GO:0010228,GO:0010244,GO:0010617,GO:0014070,GO:0016043,GO:0016604,GO:0016829,GO:0016830,GO:0017076,GO:0018298,GO:0019222,GO:0019538,GO:0019637,GO:0019725,GO:0022414,GO:0022603,GO:0023052,GO:0030003,GO:0030522,GO:0030554,GO:0031323,GO:0031325,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0033993,GO:0034641,GO:0035639,GO:0036094,GO:0036211,GO:0038023,GO:0040008,GO:0042221,GO:0042592,GO:0042726,GO:0042752,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0048037,GO:0048507,GO:0048509,GO:0048511,GO:0048518,GO:0048522,GO:0048571,GO:0048573,GO:0048574,GO:0048580,GO:0048582,GO:0048583,GO:0048608,GO:0048638,GO:0048731,GO:0048831,GO:0048856,GO:0048878,GO:0050660,GO:0050662,GO:0050789,GO:0050793,GO:0050794,GO:0050801,GO:0050896,GO:0051094,GO:0051186,GO:0051239,GO:0051240,GO:0051276,GO:0051480,GO:0051607,GO:0051704,GO:0051707,GO:0051716,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0055086,GO:0060089,GO:0061458,GO:0065007,GO:0065008,GO:0070013,GO:0071214,GO:0071478,GO:0071482,GO:0071483,GO:0071704,GO:0071840,GO:0071949,GO:0072387,GO:0072503,GO:0072507,GO:0090304,GO:0097159,GO:0097367,GO:0098542,GO:0098771,GO:0104004,GO:0140097,GO:1900618,GO:1901265,GO:1901360,GO:1901363,GO:1901371,GO:1901564,GO:1901700,GO:1902347,GO:1905421,GO:2000024,GO:2000026,GO:2000028,GO:2000241,GO:2000243,GO:2000377,GO:2000379 4.1.99.3 ko:K01669 ko00000,ko01000,ko03400 Bacteria 2GJXU@201174,COG0415@1,COG0415@2 NA|NA|NA L Belongs to the DNA photolyase family MAG.T1.179_00455 1206101.AZXC01000007_gene2475 3.7e-64 251.5 Actinobacteria ideR ko:K03709 ko00000,ko03000 Bacteria 2GKMC@201174,COG1321@1,COG1321@2 NA|NA|NA K iron dependent repressor MAG.T1.179_00456 1463820.JOGW01000004_gene4608 3.4e-21 107.5 Actinobacteria ko:K21600 ko00000,ko03000 Bacteria 2IQ7U@201174,COG1937@1,COG1937@2 NA|NA|NA S protein conserved in bacteria MAG.T1.179_00457 479435.Kfla_0631 2.2e-30 139.0 Propionibacteriales lytE ko:K21471 ko00000,ko01000,ko01002,ko01011 Bacteria 2IFNI@201174,4DS9B@85009,COG0791@1,COG0791@2,COG3409@1,COG3409@2 NA|NA|NA M NlpC/P60 family MAG.T1.179_00458 1240349.ANGC01000010_gene2821 1.8e-92 346.7 Nocardiaceae 2.3.1.20 ko:K00635 ko00561,ko01100,map00561,map01100 M00089 R02251 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 Bacteria 2IGNH@201174,4G6IZ@85025,COG1020@1,COG1020@2 NA|NA|NA I Protein of unknown function (DUF1298) MAG.T1.179_00459 477641.MODMU_4177 8.4e-106 390.2 Frankiales 1.13.11.8 ko:K04100,ko:K15777 ko00362,ko00624,ko00627,ko00965,ko01120,map00362,map00624,map00627,map00965,map01120 R01632,R03550,R04280,R08836,R09565 RC00233,RC00387,RC00535,RC02567,RC02694 br01602,ko00000,ko00001,ko01000 Bacteria 2GKTV@201174,4ESG8@85013,COG3384@1,COG3384@2 NA|NA|NA S Extradiol ring-cleavage dioxygenase class III protein subunit B MAG.T1.179_00460 1120954.ATXE01000001_gene2216 3.3e-20 104.8 Propionibacteriales Bacteria 2IT3M@201174,4DVDP@85009,COG3877@1,COG3877@2 NA|NA|NA S Protein of unknown function (DUF2089) MAG.T1.179_00461 479435.Kfla_5620 1.3e-12 80.5 Propionibacteriales Bacteria 2B5R0@1,2IPMA@201174,31YKI@2,4DR93@85009 NA|NA|NA MAG.T1.179_00462 679197.HMPREF9336_04200 8.2e-58 231.5 Actinobacteria Bacteria 2GN56@201174,COG1835@1,COG1835@2 NA|NA|NA I Acyltransferase MAG.T1.179_00463 1144275.COCOR_03122 6.6e-25 120.2 Proteobacteria Bacteria 1NKMZ@1224,COG3832@1,COG3832@2,COG5646@1,COG5646@2 NA|NA|NA S Domain of unknown function (DU1801) MAG.T1.179_00464 369723.Strop_1612 8.7e-58 229.9 Micromonosporales perX Bacteria 2IFXH@201174,4DIG7@85008,COG2210@1,COG2210@2 NA|NA|NA S DsrE/DsrF/DrsH-like family MAG.T1.179_00465 1043493.BBLU01000020_gene1080 4.9e-32 143.7 Actinobacteria dsrC 1.8.5.4 ko:K11179,ko:K17218 ko00920,ko04122,map00920,map04122 R10152 RC03155 ko00000,ko00001,ko01000,ko03016 Bacteria 2IQB2@201174,COG2920@1,COG2920@2 NA|NA|NA P PFAM DsrC family protein MAG.T1.179_00466 926550.CLDAP_11610 6.1e-25 121.3 Bacteria Bacteria COG2427@1,COG2427@2 NA|NA|NA S Protein of unknown function (DUF1641) MAG.T1.179_00467 1304865.JAGF01000001_gene3099 1.5e-172 612.5 Actinobacteria 1.8.5.4 ko:K17218 ko00920,map00920 R10152 RC03155 ko00000,ko00001,ko01000 Bacteria 2GRTN@201174,COG0446@1,COG0446@2 NA|NA|NA P pyridine nucleotide-disulphide oxidoreductase MAG.T1.179_00468 926550.CLDAP_11630 1.5e-26 126.7 Bacteria 3.1.3.3 ko:K07315 ko00000,ko01000,ko03021 Bacteria COG2452@1,COG2452@2,COG4936@1,COG4936@2 NA|NA|NA KT Sensory domain found in PocR MAG.T1.179_00469 298654.FraEuI1c_4843 2.7e-177 628.6 Frankiales gcs2 Bacteria 2GN0J@201174,4ES9X@85013,COG2308@1,COG2308@2 NA|NA|NA S Circularly permuted ATP-grasp type 2 MAG.T1.179_00470 397278.JOJN01000019_gene2352 1.1e-44 187.2 Propionibacteriales MA20_32425 Bacteria 2GN0T@201174,4DP16@85009,COG2307@1,COG2307@2 NA|NA|NA S A predicted alpha-helical domain with a conserved ER motif. MAG.T1.179_00471 1283283.ATXA01000013_gene3448 1.7e-66 259.6 Frankiales Bacteria 2GN5D@201174,4ESH4@85013,COG1305@1,COG1305@2 NA|NA|NA E Bacterial transglutaminase-like N-terminal region MAG.T1.179_00472 1229780.BN381_130301 6.6e-50 204.1 unclassified Actinobacteria (class) plsC2 Bacteria 2IDC7@201174,3UXB2@52018,COG0204@1,COG0204@2 NA|NA|NA I Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.179_00474 102129.Lepto7375DRAFT_2915 1e-54 219.9 Oscillatoriales apt 2.4.2.7 ko:K00759 ko00230,ko01100,map00230,map01100 R00190,R01229,R04378 RC00063 ko00000,ko00001,ko01000,ko04147 Bacteria 1G508@1117,1HAKH@1150,COG0503@1,COG0503@2 NA|NA|NA F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis MAG.T1.179_00475 1043493.BBLU01000006_gene2218 1.3e-57 230.3 Actinobacteria Bacteria 2I8IC@201174,COG2334@1,COG2334@2 NA|NA|NA EGP Major facilitator Superfamily MAG.T1.179_00476 309800.C498_16184 4.8e-40 171.4 Halobacteria Archaea 23WKG@183963,2XXWE@28890,arCOG13341@1,arCOG13341@2157 NA|NA|NA MAG.T1.179_00477 1504319.GM45_0280 4.1e-71 274.6 unclassified Actinobacteria (class) yhhQ ko:K09125 ko00000 Bacteria 2IFDB@201174,3UX0S@52018,COG1738@1,COG1738@2 NA|NA|NA U Involved in the import of queuosine (Q) precursors, required for Q precursor salvage MAG.T1.179_00478 479431.Namu_3445 4.5e-69 268.1 Actinobacteria 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 Bacteria 2GW7W@201174,COG3001@1,COG3001@2 NA|NA|NA G Fructosamine kinase MAG.T1.179_00479 1035308.AQYY01000001_gene3393 2.2e-160 572.0 Peptococcaceae tgt 2.4.2.29 ko:K00773 R03789,R10209 RC00063 ko00000,ko01000,ko03016 Bacteria 1TNZ4@1239,247NJ@186801,260AS@186807,COG0343@1,COG0343@2 NA|NA|NA F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) MAG.T1.179_00480 1121899.Q764_09130 2.4e-22 111.3 Flavobacterium Bacteria 1I3HF@117743,2NX4C@237,4NSVZ@976,COG2314@1,COG2314@2 NA|NA|NA S Pfam TM2 domain MAG.T1.179_00481 1385520.N802_03820 1.1e-52 213.4 Intrasporangiaceae ko:K19519 ko00000,ko04516 Bacteria 2IHKV@201174,4FGQK@85021,COG2335@1,COG2335@2 NA|NA|NA M Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. MAG.T1.179_00482 590998.Celf_3363 5.3e-35 154.8 Cellulomonadaceae Bacteria 2IM7X@201174,4F2HP@85016,COG5343@1,COG5343@2 NA|NA|NA S Anti-sigma-K factor rskA MAG.T1.179_00483 590998.Celf_3362 4.2e-42 178.3 Cellulomonadaceae litS ko:K03088 ko00000,ko03021 Bacteria 2IKQ7@201174,4F2I1@85016,COG1595@1,COG1595@2 NA|NA|NA K TIGRFAM RNA polymerase sigma factor, sigma-70 family MAG.T1.179_00484 1003195.SCAT_1757 1.3e-226 793.1 Actinobacteria pepN 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 Bacteria 2GJJ4@201174,COG0308@1,COG0308@2 NA|NA|NA E aminopeptidase N MAG.T1.179_00485 28042.GU90_04140 1.3e-58 233.0 Pseudonocardiales ko:K09019 ko00240,ko01100,map00240,map01100 R09289 RC00087 ko00000,ko00001,ko01000 Bacteria 2HC1J@201174,4DZB0@85010,COG0778@1,COG0778@2 NA|NA|NA C Nitroreductase family MAG.T1.179_00486 35754.JNYJ01000005_gene5499 3.8e-09 68.9 Micromonosporales Bacteria 2FIZ9@1,2INWA@201174,34AQ2@2,4DIXT@85008 NA|NA|NA MAG.T1.179_00487 2002.JOEQ01000004_gene2898 5.6e-160 571.2 Streptosporangiales ko:K07114 ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 Bacteria 2GNSN@201174,4EH2B@85012,COG1840@1,COG1840@2,COG2304@1,COG2304@2 NA|NA|NA P von Willebrand factor type A domain MAG.T1.179_00488 1229780.BN381_210036 1.3e-76 293.1 Actinobacteria Bacteria 2GJSF@201174,COG0500@1,COG2226@2 NA|NA|NA Q methyltransferase MAG.T1.179_00489 1193181.BN10_1190010 4.9e-62 245.4 Intrasporangiaceae pepA ko:K08372 ko02020,map02020 ko00000,ko00001,ko01000,ko01002 Bacteria 2GJJ3@201174,4FJ5Z@85021,COG0265@1,COG0265@2 NA|NA|NA O Domain present in PSD-95, Dlg, and ZO-1/2. MAG.T1.179_00490 1291050.JAGE01000001_gene2582 2e-68 266.2 Ruminococcaceae hprK GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 ko:K06023 ko00000,ko01000 Bacteria 1TP5Z@1239,24999@186801,3WGB3@541000,COG1493@1,COG1493@2 NA|NA|NA H Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion MAG.T1.179_00491 1150399.AQYK01000001_gene1558 5.5e-42 177.9 Microbacteriaceae iphP 3.1.3.48,3.1.4.53 ko:K01104,ko:K03651 ko00230,ko02025,map00230,map02025 R00191 RC00296 ko00000,ko00001,ko01000 Bacteria 2GK28@201174,4FN9A@85023,COG2365@1,COG2365@2 NA|NA|NA T Tyrosine phosphatase family MAG.T1.179_00492 203119.Cthe_0110 6.1e-79 301.2 Ruminococcaceae hprK GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 ko:K06023 ko00000,ko01000 Bacteria 1TP5Z@1239,24999@186801,3WGB3@541000,COG1493@1,COG1493@2 NA|NA|NA H Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion MAG.T1.179_00493 1246445.ANAY01000013_gene117 3.8e-38 165.6 Streptosporangiales ykrP ko:K13663 ko00000,ko01000 Bacteria 2GJXP@201174,4EHTM@85012,COG3594@1,COG3594@2 NA|NA|NA G Acyltransferase family MAG.T1.179_00495 1048339.KB913029_gene479 1.9e-27 129.8 Actinobacteria Bacteria 2F8QI@1,2H6TB@201174,3412U@2 NA|NA|NA MAG.T1.179_00496 1137268.AZXF01000033_gene3440 7.6e-26 124.4 Streptosporangiales Bacteria 2I6YM@201174,4ER8Y@85012,COG1261@1,COG1261@2 NA|NA|NA NO Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly MAG.T1.179_00497 1449353.JQMQ01000005_gene5167 2.3e-25 122.9 Streptacidiphilus Bacteria 2HT5K@201174,2NF4C@228398,COG0455@1,COG0455@2 NA|NA|NA D bacterial-type flagellum organization MAG.T1.179_00498 1380354.JIAN01000009_gene3753 6.2e-133 480.7 Cellulomonadaceae ko:K02283 ko00000,ko02035,ko02044 Bacteria 2GKKJ@201174,4F10A@85016,COG4962@1,COG4962@2 NA|NA|NA U Type II/IV secretion system protein MAG.T1.179_00499 1380354.JIAN01000009_gene3754 6.5e-50 204.5 Actinobacteria Bacteria 2GN6E@201174,COG4965@1,COG4965@2 NA|NA|NA U type II secretion system MAG.T1.179_00500 1380354.JIAN01000009_gene3755 1e-50 207.2 Actinobacteria ko:K12510 ko00000,ko02044 Bacteria 2I2Z3@201174,COG4965@1,COG4965@2 NA|NA|NA U type II secretion system MAG.T1.179_00502 1380354.JIAN01000009_gene3757 5.9e-19 100.5 Bacteria Bacteria COG4961@1,COG4961@2 NA|NA|NA U PFAM TadE family protein MAG.T1.179_00503 1463853.JOHW01000040_gene6696 8.1e-22 110.2 Actinobacteria Bacteria 2GRCJ@201174,COG4961@1,COG4961@2 NA|NA|NA U PFAM TadE family protein MAG.T1.179_00504 1380356.JNIK01000001_gene2282 2.5e-21 108.6 Frankiales Bacteria 2E4ST@1,2GSCH@201174,32ZM5@2,4ETEF@85013 NA|NA|NA MAG.T1.179_00505 1380354.JIAN01000009_gene3760 1.4e-75 291.6 Actinobacteria Bacteria 2I8YV@201174,COG1652@1,COG1652@2 NA|NA|NA NU PFAM Peptidoglycan-binding LysM MAG.T1.179_00506 1305732.JAGG01000001_gene778 3.5e-16 91.3 Microbacteriaceae yidH ko:K00389 ko00000 Bacteria 2GQU9@201174,4FQ80@85023,COG2149@1,COG2149@2 NA|NA|NA S Domain of unknown function (DUF202) MAG.T1.179_00508 494419.ALPM01000043_gene2494 3.3e-34 152.5 Micrococcaceae 3.2.1.26 ko:K01193 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00801,R00802,R02410,R03635,R03921,R06088 RC00028,RC00077 ko00000,ko00001,ko01000 GH32 Bacteria 1WBZM@1268,2GJ9T@201174,COG1621@1,COG1621@2 NA|NA|NA G Belongs to the glycosyl hydrolase 32 family MAG.T1.179_00510 290397.Adeh_0949 7.1e-116 424.5 Myxococcales kup ko:K03549 ko00000,ko02000 2.A.72 Bacteria 1MUVH@1224,2WJEH@28221,2YXPN@29,42P5Y@68525,COG3158@1,COG3158@2 NA|NA|NA P Transport of potassium into the cell MAG.T1.179_00511 1283287.KB822581_gene1545 1.7e-23 117.1 Propionibacteriales 2.7.6.5 ko:K07816 ko00230,map00230 R00429 RC00002,RC00078 ko00000,ko00001,ko01000 Bacteria 2GKF8@201174,4DPS6@85009,COG2357@1,COG2357@2,COG4328@1,COG4328@2 NA|NA|NA Q Region found in RelA / SpoT proteins MAG.T1.179_00512 1108045.GORHZ_125_00320 5.7e-187 660.6 Gordoniaceae 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 Bacteria 2GIUC@201174,4GBU2@85026,COG0318@1,COG0318@2 NA|NA|NA IQ AMP-binding enzyme C-terminal domain MAG.T1.179_00513 1123322.KB904713_gene5220 1.8e-133 482.6 Actinobacteria 1.18.1.3,1.7.1.15 ko:K00362,ko:K00529 ko00071,ko00360,ko00910,ko01120,ko01220,map00071,map00360,map00910,map01120,map01220 M00530,M00545 R00787,R02000,R06782,R06783 RC00098,RC00176 br01602,ko00000,ko00001,ko00002,ko01000 Bacteria 2GJKT@201174,COG0446@1,COG0446@2 NA|NA|NA Q pyridine nucleotide-disulphide oxidoreductase MAG.T1.179_00514 1121017.AUFG01000019_gene2370 3e-56 226.5 Intrasporangiaceae ko:K14645 ko02024,map02024 ko00000,ko00001,ko01000,ko01002,ko03110 Bacteria 2GIRE@201174,4FGR4@85021,COG1404@1,COG1404@2 NA|NA|NA O Subtilase family MAG.T1.179_00515 1032480.MLP_04950 8.2e-53 214.2 Propionibacteriales tagH 3.1.3.5,3.1.3.6,3.1.4.16 ko:K01081,ko:K01119 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 R00183,R00511,R00963,R01126,R01227,R01562,R01569,R01664,R01877,R01968,R02088,R02102,R02148,R02323,R02370,R02719,R03346,R03537,R03538,R03929,R05135 RC00017,RC00078,RC00296 ko00000,ko00001,ko01000 Bacteria 2I3RJ@201174,4DR7V@85009,COG3103@1,COG3103@2 NA|NA|NA T sh3 domain protein MAG.T1.179_00517 1463936.JOJI01000077_gene65 2.3e-24 118.6 Actinobacteria Bacteria 2IBP1@201174,COG2207@1,COG2207@2 NA|NA|NA K transcriptional regulator MAG.T1.179_00518 1463934.JOCF01000050_gene7607 3.5e-14 86.3 Actinobacteria 2.1.1.107 ko:K02303,ko:K22010 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121,M00839 R03194 RC00003,RC00871 ko00000,ko00001,ko00002,ko01000,ko02022 Bacteria 2H0E2@201174,COG2203@1,COG2203@2,COG3707@1,COG3707@2 NA|NA|NA T ANTAR MAG.T1.179_00519 1304865.JAGF01000001_gene1186 2.2e-52 213.8 Actinobacteria Bacteria 2IAWA@201174,COG2199@1,COG2202@1,COG2202@2,COG3706@2 NA|NA|NA T diguanylate cyclase MAG.T1.179_00520 686340.Metal_2787 3.8e-134 485.0 Proteobacteria cpgS ko:K05716 R03298 RC00900 ko00000,ko01000 Bacteria 1MV4C@1224,COG2403@1,COG2403@2 NA|NA|NA S cyclic 2,3-diphosphoglycerate synthetase activity MAG.T1.179_00521 593907.Celgi_2417 1.8e-164 585.5 Cellulomonadaceae pfkA 2.7.1.11,2.7.1.90 ko:K00850,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 iJN678.pfkA Bacteria 2GK6W@201174,4F0UZ@85016,COG0205@1,COG0205@2 NA|NA|NA H Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis MAG.T1.179_00522 1150399.AQYK01000002_gene3209 4.5e-185 655.2 Microbacteriaceae Bacteria 2GN7G@201174,4FKX3@85023,COG3291@1,COG3291@2 NA|NA|NA G Repeats in polycystic kidney disease 1 (PKD1) and other proteins MAG.T1.179_00523 1035308.AQYY01000002_gene896 1.2e-20 105.9 Bacteria Bacteria 2DNVN@1,32ZD5@2 NA|NA|NA S Lsr2 MAG.T1.179_00524 1380370.JIBA01000015_gene318 2.6e-60 239.6 Intrasporangiaceae Bacteria 2GK3A@201174,4FFEB@85021,COG1680@1,COG1680@2 NA|NA|NA V Beta-lactamase MAG.T1.179_00525 1504672.669787050 2.2e-11 75.9 Comamonadaceae Bacteria 1R95F@1224,28J0Q@1,2VJZ5@28216,2Z8XV@2,4A9RS@80864 NA|NA|NA MAG.T1.179_00527 411483.FAEPRAA2165_03445 3.6e-74 285.0 Ruminococcaceae ko:K05833 M00247 ko00000,ko00002,ko02000 Bacteria 1TPAN@1239,247WW@186801,3WHK4@541000,COG1101@1,COG1101@2 NA|NA|NA S Psort location CytoplasmicMembrane, score MAG.T1.179_00528 574087.Acear_1446 1.2e-73 283.5 Halanaerobiales WQ51_06230 ko:K01989,ko:K05832,ko:K05833 M00247 ko00000,ko00002,ko02000 Bacteria 1TPDJ@1239,249P1@186801,3WA9B@53433,COG4120@1,COG4120@2 NA|NA|NA S PFAM Branched-chain amino acid transport system permease component MAG.T1.179_00529 1120947.ATUX01000005_gene1328 1.4e-72 280.0 Actinobacteria ko:K01989,ko:K05832 M00247 ko00000,ko00002,ko02000 Bacteria 2GKNV@201174,4D55W@85005,COG2984@1,COG2984@2 NA|NA|NA S ABC transporter substrate binding protein MAG.T1.179_00530 298653.Franean1_0560 1.5e-26 124.8 Frankiales cspC ko:K03704 ko00000,ko03000 Bacteria 2GQRU@201174,4ETAA@85013,COG1278@1,COG1278@2 NA|NA|NA K Cold shock protein MAG.T1.179_00531 1206733.BAGC01000043_gene189 5.3e-63 248.1 Nocardiaceae ko:K07454 ko00000 Bacteria 2HHZ8@201174,4G1UT@85025,COG3440@1,COG3440@2 NA|NA|NA V HNH endonuclease MAG.T1.179_00533 408672.NBCG_02347 5.8e-27 127.9 Propionibacteriales rpoC Bacteria 2GKXN@201174,4DQPK@85009,COG0739@1,COG0739@2 NA|NA|NA M PFAM NLP P60 protein MAG.T1.179_00534 1123393.KB891317_gene2319 8.2e-68 263.5 Betaproteobacteria yiiE Bacteria 1R9WQ@1224,2VQBM@28216,COG3548@1,COG3548@2 NA|NA|NA S Protein of unknown function (DUF1211) MAG.T1.179_00535 665577.JH993790_gene1709 4.3e-14 85.5 Actinobacteria Bacteria 2B5F3@1,2H0EX@201174,31Y9K@2 NA|NA|NA S Short C-terminal domain MAG.T1.179_00536 1379270.AUXF01000001_gene2074 2.6e-40 172.6 Gemmatimonadetes Bacteria 1ZTNA@142182,2ZA6T@2,arCOG10456@1 NA|NA|NA MAG.T1.179_00537 931626.Awo_c04330 1.5e-14 86.3 Eubacteriaceae Bacteria 1TTZ1@1239,25HYR@186801,25XUE@186806,COG1846@1,COG1846@2 NA|NA|NA K Transcriptional regulator MAG.T1.179_00538 1386089.N865_17375 1.8e-82 313.2 Intrasporangiaceae ko:K06889 ko00000 Bacteria 2I0E5@201174,4FJN1@85021,COG1073@1,COG1073@2 NA|NA|NA S X-Pro dipeptidyl-peptidase (S15 family) MAG.T1.179_00539 1254432.SCE1572_09945 2.1e-71 277.3 Myxococcales Bacteria 1QX82@1224,2X86M@28221,2Z3M6@29,43CYG@68525,COG5555@1,COG5555@2 NA|NA|NA N FG-GAP repeat MAG.T1.179_00540 512565.AMIS_47840 9.4e-49 200.3 Bacteria 2.7.1.48 ko:K00876 ko00240,ko00983,ko01100,map00240,map00983,map01100 R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232 RC00002,RC00017 ko00000,ko00001,ko01000 Bacteria COG0572@1,COG0572@2 NA|NA|NA F uridine kinase MAG.T1.179_00541 1192034.CAP_8770 3.4e-24 117.9 Myxococcales Bacteria 1NKMZ@1224,2WX3E@28221,2YXMJ@29,431JR@68525,COG5646@1,COG5646@2 NA|NA|NA S Domain of unknown function (DU1801) MAG.T1.179_00542 1120950.KB892759_gene6277 1e-66 261.5 Propionibacteriales Bacteria 2I2J0@201174,4DQBJ@85009,COG2385@1,COG2385@2 NA|NA|NA D PFAM Stage II sporulation D domain protein MAG.T1.179_00543 1120942.AUBM01000007_gene585 1.2e-145 523.1 Actinobacteria nplT Bacteria 2GJUT@201174,4D48F@85005,COG0366@1,COG0366@2 NA|NA|NA G Alpha amylase, catalytic domain protein MAG.T1.179_00544 77635.BISU_0868 5.4e-51 207.6 Bacteria Bacteria COG1309@1,COG1309@2 NA|NA|NA K transcriptional regulator MAG.T1.179_00545 44251.PDUR_02765 5.3e-37 161.4 Paenibacillaceae ko:K05772 ko02010,map02010 M00186 ko00000,ko00001,ko00002,ko02000 3.A.1.6.2,3.A.1.6.4 Bacteria 1UI3M@1239,27712@186822,4ISC5@91061,COG2998@1,COG2998@2 NA|NA|NA H Copper amine oxidase N-terminal domain MAG.T1.179_00546 1100721.ALKO01000016_gene1456 1.8e-86 326.2 Comamonadaceae Bacteria 1MWDP@1224,2VHM1@28216,4ABW8@80864,COG3191@1,COG3191@2 NA|NA|NA EQ PFAM peptidase S58 DmpA MAG.T1.179_00547 1380390.JIAT01000010_gene3784 3.5e-27 128.6 Actinobacteria 1.3.1.33 ko:K00218 ko00860,ko01100,ko01110,map00860,map01100,map01110 R03845,R06286 RC01008 ko00000,ko00001,ko01000 Bacteria 2I3A4@201174,COG4221@1,COG4221@2 NA|NA|NA S short chain dehydrogenase MAG.T1.179_00548 1172188.KB911822_gene998 6e-58 231.1 Intrasporangiaceae ko:K06996 ko00000 Bacteria 2GJFC@201174,4FGZF@85021,COG3324@1,COG3324@2 NA|NA|NA S glyoxalase bleomycin resistance protein dioxygenase MAG.T1.179_00549 1323663.AROI01000026_gene1819 9.4e-75 288.5 Proteobacteria Bacteria 1MU2C@1224,COG5001@1,COG5001@2 NA|NA|NA T Diguanylate cyclase MAG.T1.179_00550 1386089.N865_06805 1e-166 593.2 Intrasporangiaceae ndh 1.6.99.3 ko:K03885 ko00190,map00190 ko00000,ko00001,ko01000 Bacteria 2GJFE@201174,4FENQ@85021,COG1252@1,COG1252@2 NA|NA|NA C NADH dehydrogenase MAG.T1.179_00551 1032480.MLP_00540 3.1e-170 605.5 Propionibacteriales hvsT ko:K03321 ko00000,ko02000 2.A.53.3 Bacteria 2GJCB@201174,4DP1B@85009,COG0659@1,COG0659@2,COG4530@1,COG4530@2 NA|NA|NA P Sulfate permease family MAG.T1.179_00552 1128421.JAGA01000001_gene2274 2.3e-106 392.1 unclassified Bacteria scrK 2.7.1.2,2.7.1.4 ko:K00845,ko:K00847 ko00010,ko00051,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00051,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R00760,R00867,R01600,R01786,R03920 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 2NQJS@2323,COG1940@1,COG1940@2 NA|NA|NA GK ROK family MAG.T1.179_00554 767434.Fraau_3109 2.3e-49 201.8 Xanthomonadales trmL GO:0001510,GO:0002128,GO:0002130,GO:0002131,GO:0002132,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.207 ko:K03216 ko00000,ko01000,ko03016 Bacteria 1RCY4@1224,1S3PI@1236,1X643@135614,COG0219@1,COG0219@2 NA|NA|NA J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide MAG.T1.179_00555 743718.Isova_0180 2.2e-70 272.3 Promicromonosporaceae tipA ko:K21744 ko00000,ko03000 Bacteria 2H5GI@201174,4F45E@85017,COG0789@1,COG0789@2 NA|NA|NA K TipAS antibiotic-recognition domain MAG.T1.179_00556 1463881.KL591002_gene4566 6.4e-28 131.0 Bacteria yahN GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015318,GO:0015711,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:1903825,GO:1905039 ko:K03329,ko:K16327 ko00000,ko02000 2.A.76.1.3,2.A.76.1.6 Bacteria COG1280@1,COG1280@2 NA|NA|NA E homoserine transmembrane transporter activity MAG.T1.179_00557 266940.Krad_3445 3.4e-96 358.2 Actinobacteria aroE GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 Bacteria 2GPXV@201174,COG0169@1,COG0169@2 NA|NA|NA E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) MAG.T1.179_00559 1136417.AZWE01000022_gene2611 1.1e-31 143.3 Micromonosporales Bacteria 2ENA9@1,2IS82@201174,33FXZ@2,4DF28@85008 NA|NA|NA MAG.T1.179_00560 1123023.JIAI01000001_gene6982 2.3e-08 65.5 Pseudonocardiales ko:K06893 ko00000 Bacteria 2HPCK@201174,4E7Y5@85010,COG5485@1,COG5485@2 NA|NA|NA S SnoaL-like polyketide cyclase MAG.T1.179_00561 1380370.JIBA01000012_gene3687 1.8e-29 134.8 Actinobacteria Bacteria 2EAYY@1,2I2ZT@201174,334ZV@2 NA|NA|NA S Protein of unknown function (DUF4242) MAG.T1.179_00562 1283299.AUKG01000005_gene135 1.4e-12 81.6 Rubrobacteria Bacteria 2I4C3@201174,4CQSU@84995,COG0823@1,COG0823@2 NA|NA|NA U Involved in the tonB-independent uptake of proteins MAG.T1.179_00563 512565.AMIS_64340 9.8e-10 69.3 Micromonosporales Bacteria 2CIG4@1,2HUTV@201174,33C84@2,4DFZJ@85008 NA|NA|NA MAG.T1.179_00564 196162.Noca_3735 4.4e-77 294.7 Propionibacteriales Bacteria 28P5T@1,2GP34@201174,2ZC0N@2,4DNI7@85009 NA|NA|NA MAG.T1.179_00565 1121924.ATWH01000005_gene2551 1.6e-25 121.7 Actinobacteria Bacteria 2BAGM@1,2H8NG@201174,323X7@2 NA|NA|NA MAG.T1.179_00566 1137268.AZXF01000040_gene3328 6.9e-22 109.8 Bacteria ko:K06218 ko00000,ko02048 Bacteria COG2026@1,COG2026@2 NA|NA|NA DJ nuclease activity MAG.T1.179_00567 710696.Intca_0789 1.7e-137 496.1 Intrasporangiaceae Bacteria 2GS79@201174,4FFP0@85021,COG3547@1,COG3547@2 NA|NA|NA L Transposase MAG.T1.179_00570 457425.XNR_2969 2.2e-81 310.5 Actinobacteria Bacteria 2GNFI@201174,COG0583@1,COG0583@2 NA|NA|NA K DNA-binding transcription factor activity MAG.T1.179_00571 101510.RHA1_ro11282 2e-120 439.1 Nocardiaceae Bacteria 2GKXH@201174,4G1SK@85025,COG2842@1,COG2842@2 NA|NA|NA S AAA domain MAG.T1.179_00572 101510.RHA1_ro11283 1e-189 670.2 Nocardiaceae ko:K07497 ko00000 Bacteria 2HITH@201174,4FZG5@85025,COG2801@1,COG2801@2 NA|NA|NA L Transposition protein MAG.T1.179_00573 101510.RHA1_ro11284 7.5e-63 247.3 Actinobacteria Bacteria 2BSDG@1,2I51E@201174,32MFF@2 NA|NA|NA S Evidence 4 Homologs of previously reported genes of MAG.T1.179_00574 1123320.KB889730_gene6044 5.1e-190 670.6 Actinobacteria dnaB GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0030312,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 ko00000,ko00001,ko01000,ko03032 Bacteria 2GKXQ@201174,COG0305@1,COG0305@2 NA|NA|NA L Participates in initiation and elongation during chromosome replication MAG.T1.179_00575 1463853.JOHW01000024_gene4633 6.6e-33 147.1 Actinobacteria ptpA 3.1.3.48 ko:K01104 ko00000,ko01000 Bacteria 2IM0Q@201174,COG0394@1,COG0394@2 NA|NA|NA T Belongs to the low molecular weight phosphotyrosine protein phosphatase family MAG.T1.179_00576 745411.B3C1_05887 2e-23 117.1 Gammaproteobacteria ispD GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0050518,GO:0070567 2.7.7.60,4.6.1.12 ko:K00991,ko:K12506 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633,R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 Bacteria 1QVUF@1224,1T2J7@1236,COG1211@1,COG1211@2,COG5295@1,COG5295@2 NA|NA|NA UW this gene contains a nucleotide ambiguity which may be the result of a sequencing error MAG.T1.179_00577 1122611.KB903955_gene5558 1.8e-43 182.2 Streptosporangiales rplI GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02939 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IKX7@201174,4EIIV@85012,COG0359@1,COG0359@2 NA|NA|NA J binds to the 23S rRNA MAG.T1.179_00578 479431.Namu_5367 1.5e-28 131.7 Frankiales rpsR GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02963,ko:K03111,ko:K15125 ko03010,ko03030,ko03430,ko03440,ko05133,map03010,map03030,map03430,map03440,map05133 M00178 br01610,ko00000,ko00001,ko00002,ko00536,ko03011,ko03029,ko03032,ko03400 Bacteria 2IQ92@201174,4ESZ0@85013,COG0238@1,COG0238@2 NA|NA|NA J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit MAG.T1.179_00579 471853.Bcav_4180 9.6e-49 199.9 Actinobacteria ssb GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0033554,GO:0042221,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071944,GO:0097159,GO:1901363 ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 ko00000,ko00001,ko03029,ko03032,ko03400 Bacteria 2GMM3@201174,COG0629@1,COG0629@2 NA|NA|NA L single-stranded DNA-binding protein MAG.T1.179_00580 1121927.GOHSU_53_00040 2e-35 154.8 Gordoniaceae rpsF GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0019843,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071944,GO:0097159,GO:1901363,GO:1990904 ko:K02990 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011,ko03029 Bacteria 2IQHD@201174,4GEI3@85026,COG0360@1,COG0360@2 NA|NA|NA J Binds together with S18 to 16S ribosomal RNA MAG.T1.179_00581 1348663.KCH_39330 2.4e-127 462.2 Kitasatospora femA Bacteria 2GJUD@201174,2M0RF@2063,COG2348@1,COG2348@2 NA|NA|NA V FemAB family MAG.T1.179_00582 397278.JOJN01000003_gene1778 1.3e-53 217.2 Propionibacteriales Bacteria 2GJJX@201174,4DNS3@85009,COG0787@1,COG0787@2 NA|NA|NA M Alanine racemase, N-terminal domain MAG.T1.179_00583 1449347.JQLN01000005_gene4485 1.9e-113 416.4 Kitasatospora Bacteria 2GJYA@201174,2M0JK@2063,COG5650@1,COG5650@2 NA|NA|NA S Pfam:DUF2029 MAG.T1.179_00584 1504319.GM45_1640 1.7e-155 556.6 unclassified Actinobacteria (class) mrcB 2.4.1.129,3.4.16.4 ko:K05365,ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 GT51 Bacteria 2GK21@201174,3UX6W@52018,COG0744@1,COG0744@2 NA|NA|NA M Transglycosylase MAG.T1.179_00585 1048339.KB913029_gene1638 9.3e-30 136.3 Actinobacteria Bacteria 2CQNK@1,2I83S@201174,323RQ@2 NA|NA|NA S Family of unknown function (DUF5318) MAG.T1.179_00586 266940.Krad_0158 6.3e-88 330.9 Actinobacteria fpg 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 2GKAM@201174,COG0266@1,COG0266@2 NA|NA|NA L Belongs to the FPG family MAG.T1.179_00587 1054860.KB913030_gene3290 6.4e-122 444.9 Actinobacteria 2.7.11.1 ko:K12132 ko00000,ko01000,ko01001 Bacteria 2GJ1J@201174,COG0515@1,COG0515@2,COG2815@1,COG2815@2 NA|NA|NA KLT serine threonine protein kinase MAG.T1.179_00588 1120950.KB892743_gene3151 4.8e-130 471.5 Propionibacteriales pbpA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 ko:K05364 ko00550,map00550 R04519 RC00005,RC00049 ko00000,ko00001,ko01011 Bacteria 2GJUQ@201174,4DP0A@85009,COG0768@1,COG0768@2 NA|NA|NA M Penicillin binding protein transpeptidase domain MAG.T1.179_00589 935866.JAER01000017_gene4377 3.7e-119 435.3 Propionibacteriales rodA GO:0002682,GO:0002684,GO:0008150,GO:0009605,GO:0009607,GO:0009987,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051301,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0075136 ko:K03588,ko:K05364,ko:K05837 ko00550,ko04112,map00550,map04112 R04519 RC00005,RC00049 ko00000,ko00001,ko01011,ko02000,ko03036 2.A.103.1 Bacteria 2GJTI@201174,4DPN4@85009,COG0772@1,COG0772@2 NA|NA|NA D Belongs to the SEDS family MAG.T1.179_00590 1449346.JQMO01000003_gene4362 1.8e-77 297.0 Kitasatospora 3.1.3.16 ko:K20074 ko00000,ko01000,ko01009 Bacteria 2GJ3M@201174,2M11G@2063,COG0631@1,COG0631@2 NA|NA|NA T Protein phosphatase 2C MAG.T1.179_00591 561175.KB894093_gene3929 1.7e-34 152.5 Streptosporangiales fhaB GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0016020,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051301,GO:0051704,GO:0071944 Bacteria 2GKA7@201174,4EJS2@85012,COG1716@1,COG1716@2 NA|NA|NA T Inner membrane component of T3SS, cytoplasmic domain MAG.T1.179_00592 266940.Krad_0077 1.2e-54 219.9 Actinobacteria fhaA GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097159,GO:1901363 ko:K02283 ko00000,ko02035,ko02044 Bacteria 2GNU2@201174,COG1716@1,COG1716@2 NA|NA|NA T (FHA) domain MAG.T1.179_00593 1380346.JNIH01000032_gene1139 5.2e-62 245.4 Actinobacteria 2.7.4.9 ko:K00943,ko:K08217 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 br01600,ko00000,ko00001,ko00002,ko01000,ko01504,ko02000 2.A.1.21.1,2.A.1.21.22 Bacteria 2GK5A@201174,COG2270@1,COG2270@2 NA|NA|NA S Major facilitator Superfamily MAG.T1.179_00594 1003195.SCAT_3138 3.6e-175 620.9 Actinobacteria ino1 GO:0003674,GO:0003824,GO:0004512,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009405,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016853,GO:0016872,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659 5.5.1.4 ko:K01858 ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130 R07324 RC01804 ko00000,ko00001,ko01000 Bacteria 2GKHB@201174,COG1260@1,COG1260@2 NA|NA|NA I myo-inositol-1-phosphate synthase MAG.T1.179_00595 1210045.ALNP01000002_gene4122 1.5e-64 252.7 Actinobacteria laaE Bacteria 2GMJM@201174,COG1695@1,COG1695@2 NA|NA|NA K Transcriptional regulator MAG.T1.179_00596 710696.Intca_0624 1.4e-151 542.7 Intrasporangiaceae Bacteria 2IAMG@201174,4FFB5@85021,COG0427@1,COG0427@2 NA|NA|NA C 4-hydroxybutyrate CoA-transferase MAG.T1.179_00597 1122933.JNIY01000004_gene2358 6e-37 161.0 Cellulomonadaceae Bacteria 2I2GH@201174,4F1NA@85016,COG3583@1,COG3583@2 NA|NA|NA S G5 MAG.T1.179_00598 1380356.JNIK01000021_gene4538 5.3e-69 267.7 Actinobacteria glpF ko:K02440,ko:K06188 ko00000,ko02000 1.A.8,1.A.8.1,1.A.8.2 Bacteria 2GKK3@201174,COG0580@1,COG0580@2 NA|NA|NA G Belongs to the MIP aquaporin (TC 1.A.8) family MAG.T1.179_00599 1140001.I571_02495 5.1e-36 157.5 Enterococcaceae cca 2.7.7.19,2.7.7.72 ko:K00970,ko:K00974,ko:K19545 ko03013,ko03018,map03013,map03018 R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko01504,ko03016,ko03019 Bacteria 1V1W2@1239,4B2N1@81852,4HVHZ@91061,COG0617@1,COG0617@2 NA|NA|NA J Aminoglycoside-2''-adenylyltransferase MAG.T1.179_00601 266117.Rxyl_2066 7.5e-115 421.4 Rubrobacteria oatA GO:0000271,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016020,GO:0016051,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509 ko:K19172 ko00000,ko02048 Bacteria 2GKI5@201174,4CQDA@84995,COG1835@1,COG1835@2,COG2755@1,COG2755@2 NA|NA|NA I Acyltransferase family MAG.T1.179_00602 1463887.KL590002_gene4201 5.8e-20 104.4 Actinobacteria Bacteria 2IIEK@201174,COG1670@1,COG1670@2 NA|NA|NA J Acetyltransferase (GNAT) domain MAG.T1.179_00603 1157632.AQWQ01000003_gene1787 3.3e-176 624.8 Actinobacteria cca 2.7.7.19,2.7.7.72 ko:K00970,ko:K00974 ko03013,ko03018,map03013,map03018 R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016,ko03019 Bacteria 2GMT1@201174,COG0617@1,COG0617@2 NA|NA|NA J tRNA nucleotidyltransferase poly(A) polymerase MAG.T1.179_00604 675635.Psed_6673 8.7e-49 200.7 Pseudonocardiales Bacteria 2I2DG@201174,4E30H@85010,COG1051@1,COG1051@2 NA|NA|NA F Belongs to the Nudix hydrolase family MAG.T1.179_00606 1120950.KB892740_gene2538 2.2e-10 72.4 Propionibacteriales Bacteria 2GN00@201174,4DQW4@85009,COG3170@1,COG3170@2 NA|NA|NA NU Tfp pilus assembly protein FimV MAG.T1.179_00610 1120950.KB892740_gene2536 1.7e-55 223.8 Propionibacteriales Bacteria 2GM4A@201174,4DN49@85009,COG0515@1,COG0515@2 NA|NA|NA KLT serine threonine protein kinase MAG.T1.179_00611 1184609.KILIM_019_00760 1.3e-128 466.1 Dermatophilaceae trxB GO:0000166,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.9,4.3.1.9 ko:K00384,ko:K22345 ko00030,ko00450,map00030,map00450 R01544,R02016,R03596,R09372 RC00013,RC00544,RC02518,RC02873 ko00000,ko00001,ko01000 iPC815.YPO1374 Bacteria 2GKD2@201174,4F6I4@85018,COG0492@1,COG0492@2 NA|NA|NA O Pyridine nucleotide-disulphide oxidoreductase MAG.T1.179_00612 67315.JOBD01000019_gene7672 2.1e-38 164.9 Actinobacteria trxA GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.8.1.8 ko:K03671,ko:K03672 ko04621,ko05418,map04621,map05418 ko00000,ko00001,ko01000,ko03110 Bacteria 2IQ9T@201174,COG3118@1,COG3118@2 NA|NA|NA O belongs to the thioredoxin family MAG.T1.179_00613 1048339.KB913029_gene1659 6.4e-90 337.8 Frankiales cwlM GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464 3.2.1.17,3.5.1.28 ko:K01185,ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 Bacteria 2GPA9@201174,4ERBQ@85013,COG0860@1,COG0860@2,COG3409@1,COG3409@2 NA|NA|NA M Cell wall hydrolase autolysin MAG.T1.179_00614 1032480.MLP_35050 8.1e-15 89.4 Propionibacteriales Bacteria 2IBN6@201174,4DP5E@85009,COG1502@1,COG1502@2 NA|NA|NA I PLD-like domain MAG.T1.179_00616 1454010.JEOE01000029_gene3028 5.9e-151 540.8 Cellulomonadaceae avtA ko:K05825 ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210 R01939 RC00006 ko00000,ko00001,ko01000 Bacteria 2GITW@201174,4F2B4@85016,COG1167@1,COG1167@2 NA|NA|NA EK Aminotransferase class I and II MAG.T1.179_00617 471852.Tcur_4976 8.6e-96 357.1 Streptosporangiales ddl 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 Bacteria 2GRWM@201174,4EFUD@85012,COG1181@1,COG1181@2 NA|NA|NA M Belongs to the D-alanine--D-alanine ligase family MAG.T1.179_00618 443218.AS9A_0015 1.1e-06 60.8 Actinobacteria Bacteria 291QM@1,2H0PF@201174,2ZPAP@2 NA|NA|NA MAG.T1.179_00619 1121385.AQXW01000004_gene2687 8.8e-89 333.6 Dermacoccaceae parB GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005694,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0060187,GO:0071944 ko:K03497 ko00000,ko03000,ko03036,ko04812 Bacteria 1ZVBH@145357,2GNRN@201174,COG1475@1,COG1475@2 NA|NA|NA K Belongs to the ParB family MAG.T1.179_00620 585531.HMPREF0063_10409 1.3e-50 206.5 Propionibacteriales rsmG GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 ko:K03501 ko00000,ko01000,ko03009,ko03036 Bacteria 2GM9Z@201174,4DQN8@85009,COG0357@1,COG0357@2 NA|NA|NA M Specifically methylates the N7 position of a guanine in 16S rRNA MAG.T1.179_00621 1157637.KB892093_gene6652 7.8e-50 203.4 Actinobacteria jag ko:K06346,ko:K09749 ko00000 Bacteria 2GPZK@201174,COG1847@1,COG1847@2 NA|NA|NA S R3H domain protein MAG.T1.179_00622 1504319.GM45_6245 3e-88 332.0 unclassified Actinobacteria (class) yidC ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 Bacteria 2GJBU@201174,3UWKK@52018,COG0706@1,COG0706@2 NA|NA|NA U 60Kd inner membrane protein MAG.T1.179_00623 888439.HMPREF9240_01622 6.9e-24 116.7 Actinobacteria yidD ko:K08998 ko00000 Bacteria 2GQZG@201174,4D6B8@85005,COG0759@1,COG0759@2 NA|NA|NA S Could be involved in insertion of integral membrane proteins into the membrane MAG.T1.179_00624 1463820.JOGW01000006_gene6872 3.5e-11 73.2 Actinobacteria rpmH GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02914 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GQFY@201174,COG0230@1,COG0230@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL34 family MAG.T1.179_00625 1504319.GM45_6225 4.2e-171 607.8 unclassified Actinobacteria (class) dnaA GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006172,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009133,GO:0009135,GO:0009136,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009179,GO:0009180,GO:0009185,GO:0009188,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016311,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046031,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990837 ko:K02313 ko02020,ko04112,map02020,map04112 ko00000,ko00001,ko03032,ko03036 Bacteria 2GJKI@201174,3UW7I@52018,COG0593@1,COG0593@2 NA|NA|NA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids MAG.T1.179_00626 1123322.KB904669_gene3635 1.4e-113 416.4 Actinobacteria dnaN GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 2GJK3@201174,COG0592@1,COG0592@2 NA|NA|NA L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria MAG.T1.179_00627 436229.JOEH01000010_gene5297 1.6e-112 412.9 Streptacidiphilus recF GO:0000731,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0018130,GO:0019438,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901576 ko:K03629,ko:K07459 ko03440,map03440 ko00000,ko00001,ko03400 Bacteria 2GJCS@201174,2NGB8@228398,COG1195@1,COG1195@2 NA|NA|NA L AAA domain MAG.T1.179_00628 426716.JOAJ01000009_gene5889 2.4e-29 135.6 Nocardiaceae Bacteria 2GNQ4@201174,4FUXM@85025,COG5512@1,COG5512@2 NA|NA|NA S Belongs to the UPF0232 family MAG.T1.179_00629 1504319.GM45_6205 3.5e-285 987.3 unclassified Actinobacteria (class) gyrB GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 5.99.1.3 ko:K02470 ko00000,ko01000,ko03032,ko03400 Bacteria 2GKGP@201174,3UW89@52018,COG0187@1,COG0187@2 NA|NA|NA L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner MAG.T1.179_00630 1504319.GM45_6200 0.0 1144.4 unclassified Actinobacteria (class) gyrA GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 5.99.1.3 ko:K02469 ko00000,ko01000,ko03032,ko03400 Bacteria 2GJ2Q@201174,3UWEZ@52018,COG0188@1,COG0188@2 NA|NA|NA L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner MAG.T1.179_00631 1283287.KB822575_gene768 6.4e-21 107.8 Propionibacteriales GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 Bacteria 2GKZP@201174,4DR9G@85009,COG3266@1,COG3266@2 NA|NA|NA S Transmembrane domain of unknown function (DUF3566) MAG.T1.179_00635 1203605.HMPREF1531_01896 3e-63 248.1 Propionibacteriales ppiA GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0030312,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0071704,GO:0071944,GO:0140096,GO:1901564 5.2.1.8 ko:K01802,ko:K03767,ko:K03768 ko01503,ko04217,map01503,map04217 ko00000,ko00001,ko01000,ko03110,ko04147 Bacteria 2IFUE@201174,4DQA4@85009,COG0652@1,COG0652@2 NA|NA|NA O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides MAG.T1.179_00636 1122611.KB903952_gene5829 4.1e-40 171.8 Streptosporangiales gluP 3.4.21.105 ko:K19225 ko00000,ko01000,ko01002 Bacteria 2GJYG@201174,4EH62@85012,COG0705@1,COG0705@2 NA|NA|NA S Rhomboid family MAG.T1.179_00637 2002.JOEQ01000029_gene8208 9.9e-15 85.9 Streptosporangiales crgA Bacteria 2E4NY@1,2HZN4@201174,32ZHR@2,4EKK3@85012 NA|NA|NA D Involved in cell division MAG.T1.179_00638 1193181.BN10_150004 1e-42 180.3 Intrasporangiaceae Bacteria 2GJ9Y@201174,4FFV4@85021,COG3879@1,COG3879@2 NA|NA|NA S Bacterial protein of unknown function (DUF881) MAG.T1.179_00639 1123320.KB889730_gene5990 6e-77 293.9 Actinobacteria trpG GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 2.6.1.85 ko:K01664,ko:K13950 ko00790,map00790 R01716 RC00010,RC01418 ko00000,ko00001,ko01000 Bacteria 2GJUX@201174,COG0512@1,COG0512@2 NA|NA|NA EH Glutamine amidotransferase of anthranilate synthase MAG.T1.179_00640 1463926.JOCA01000003_gene5189 2.6e-123 448.7 Actinobacteria ybdL GO:0003674,GO:0003824,GO:0005488,GO:0008144,GO:0008483,GO:0010326,GO:0016740,GO:0016769,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 2.6.1.17,2.6.1.88 ko:K14267,ko:K14287 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04475,R08618 RC00006,RC00025 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 2GJ7R@201174,COG0436@1,COG0436@2 NA|NA|NA E Aminotransferase MAG.T1.179_00641 1193181.BN10_800007 3.2e-72 278.5 Intrasporangiaceae ko:K07124 ko00000 Bacteria 2GKJE@201174,4FFCH@85021,COG0300@1,COG0300@2 NA|NA|NA S Belongs to the short-chain dehydrogenases reductases (SDR) family MAG.T1.179_00642 1120936.KB907212_gene5233 1.9e-12 79.3 Streptosporangiales 2.3.1.43 ko:K00650 ko00564,ko04979,map00564,map04979 R02114 RC00037,RC00055 ko00000,ko00001,ko01000 Bacteria 2IAEU@201174,4EQDC@85012,COG1075@1,COG1075@2 NA|NA|NA S acetyltransferases and hydrolases with the alpha beta hydrolase fold MAG.T1.179_00643 1003195.SCAT_3322 1.6e-70 272.3 Actinobacteria pyrE 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 iJN678.umpS Bacteria 2GKUQ@201174,COG0461@1,COG0461@2 NA|NA|NA F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) MAG.T1.179_00644 1179773.BN6_83110 6.7e-71 273.9 Pseudonocardiales dedA ko:K03975 ko00000 Bacteria 2GKGR@201174,4DX3S@85010,COG0586@1,COG0586@2 NA|NA|NA S SNARE associated Golgi protein MAG.T1.179_00645 465515.Mlut_02030 2.8e-71 275.0 Micrococcaceae spoU 2.1.1.185 ko:K03218,ko:K03437 ko00000,ko01000,ko03009,ko03016 Bacteria 1W7E6@1268,2GM1A@201174,COG0566@1,COG0566@2 NA|NA|NA J rRNA methyltransferase MAG.T1.179_00647 1179773.BN6_01060 2.4e-55 221.9 Pseudonocardiales ftn 1.16.3.1,1.16.3.2 ko:K02217,ko:K22336 ko00860,map00860 R00078 RC02758 ko00000,ko00001,ko01000 Bacteria 2IG5S@201174,4E2T6@85010,COG1528@1,COG1528@2 NA|NA|NA P Iron-storage protein MAG.T1.179_00648 66897.DJ64_03950 1.6e-135 490.3 Actinobacteria dnaX GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0042575,GO:0042802,GO:0043170,GO:0043846,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050790,GO:0061695,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 2GJKA@201174,COG2812@1,COG2812@2 NA|NA|NA L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity MAG.T1.179_00649 1120936.KB907212_gene5028 5.5e-88 330.5 Streptosporangiales recR GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 ko:K06187 ko03440,map03440 ko00000,ko00001,ko03400 Bacteria 2GJY0@201174,4EG4M@85012,COG0353@1,COG0353@2 NA|NA|NA L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO MAG.T1.179_00650 44060.JODL01000011_gene1967 3.4e-42 178.3 Actinobacteria Bacteria 299JI@1,2GMZP@201174,2ZWN1@2 NA|NA|NA S Domain of unknown function (DUF5063) MAG.T1.179_00651 479432.Sros_9311 2e-167 595.5 Streptosporangiales ask 1.1.1.3,2.7.2.4 ko:K00928,ko:K12524 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480,R01773,R01775 RC00002,RC00043,RC00087 ko00000,ko00001,ko00002,ko01000 Bacteria 2GN0G@201174,4EG8Z@85012,COG0527@1,COG0527@2 NA|NA|NA E ACT domain MAG.T1.179_00652 593907.Celgi_2847 9e-139 500.0 Cellulomonadaceae asd GO:0003674,GO:0003824,GO:0004073,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv3708c Bacteria 2GJJ8@201174,4F0DR@85016,COG0136@1,COG0136@2 NA|NA|NA E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate MAG.T1.179_00654 1120950.KB892762_gene5503 3.5e-78 298.5 Propionibacteriales ykuE ko:K07098 ko00000 Bacteria 2GJHT@201174,4DNBM@85009,COG1408@1,COG1408@2 NA|NA|NA S Calcineurin-like phosphoesterase MAG.T1.179_00655 1137269.AZWL01000006_gene6602 1.2e-31 142.9 Actinobacteria yqeY ko:K09117 ko00000 Bacteria 2IFFJ@201174,COG1610@1,COG1610@2 NA|NA|NA S GatB YqeY MAG.T1.179_00656 1504319.GM45_3810 1.2e-180 640.2 unclassified Actinobacteria (class) pon1 2.4.1.129,3.4.16.4 ko:K05365,ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 GT51 Bacteria 2GK21@201174,3UW69@52018,COG0744@1,COG0744@2 NA|NA|NA M Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.179_00657 105420.BBPO01000071_gene4045 5.4e-140 504.2 Streptacidiphilus arsA 3.6.3.16 ko:K01551 ko00000,ko01000,ko02000 3.A.19.1,3.A.21.1,3.A.4.1 Bacteria 2GJYN@201174,2NHKM@228398,COG0003@1,COG0003@2 NA|NA|NA D Anion-transporting ATPase MAG.T1.179_00658 653045.Strvi_9002 6.2e-100 370.9 Actinobacteria arsA GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 3.6.3.16 ko:K01551 ko00000,ko01000,ko02000 3.A.19.1,3.A.21.1,3.A.4.1 Bacteria 2GJ0J@201174,COG0003@1,COG0003@2 NA|NA|NA D Pfam Anion-transporting ATPase MAG.T1.179_00659 269800.Tfu_0115 2.2e-42 179.5 Streptosporangiales MA20_36340 Bacteria 2GN6D@201174,4EFJ2@85012,COG0494@1,COG0494@2 NA|NA|NA L NUDIX hydrolase MAG.T1.179_00660 1184607.AUCHE_04_00900 3.3e-48 198.0 Dermatophilaceae Bacteria 2IHNE@201174,4F6ZV@85018,COG0251@1,COG0251@2 NA|NA|NA J Endoribonuclease L-PSP MAG.T1.179_00661 1169154.KB897777_gene3606 3e-17 93.6 Actinobacteria Bacteria 2E3JZ@1,2GQIX@201174,32YI8@2 NA|NA|NA MAG.T1.179_00662 105420.BBPO01000071_gene4051 3.4e-78 298.1 Streptacidiphilus glxR GO:0000166,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010675,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030312,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0032993,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000874,GO:2001141 ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 ko00000,ko00001,ko03000 Bacteria 2GMPN@201174,2NFJS@228398,COG0664@1,COG0664@2 NA|NA|NA T helix_turn_helix, cAMP Regulatory protein MAG.T1.179_00663 351607.Acel_1994 2.2e-26 125.6 Frankiales Bacteria 2AZUF@1,2HU1W@201174,31S3S@2,4EWGK@85013 NA|NA|NA MAG.T1.179_00664 1120950.KB892762_gene5486 1.4e-90 339.3 Propionibacteriales nth GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0030312,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 4.2.99.18 ko:K10773 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 2GJ01@201174,4DNJN@85009,COG0177@1,COG0177@2 NA|NA|NA L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate MAG.T1.179_00665 1120950.KB892762_gene5484 3.3e-62 245.0 Propionibacteriales Bacteria 2GKG9@201174,4DQJF@85009,COG0494@1,COG0494@2 NA|NA|NA L NUDIX domain MAG.T1.179_00666 1122182.KB903835_gene4527 5.4e-47 195.3 Micromonosporales cvpA GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009268,GO:0009405,GO:0009628,GO:0010447,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051704,GO:0071944 Bacteria 2GJ92@201174,4DA7U@85008,COG0265@1,COG0265@2 NA|NA|NA O Peptidase s1 and s6 chymotrypsin hap MAG.T1.179_00667 1123320.KB889692_gene167 1.5e-100 372.9 Actinobacteria Bacteria 2I2IM@201174,COG2267@1,COG2267@2 NA|NA|NA I Alpha beta hydrolase MAG.T1.179_00668 1380356.JNIK01000011_gene1918 3e-13 82.0 Frankiales Bacteria 2DPPE@1,2IN30@201174,332VJ@2,4ETAT@85013 NA|NA|NA S Putative Actinobacterial Holin-X, holin superfamily III MAG.T1.179_00669 1123320.KB889692_gene169 1.3e-105 390.2 Actinobacteria nhaA ko:K03313 ko00000,ko02000 2.A.33.1 Bacteria 2GKIK@201174,COG3004@1,COG3004@2 NA|NA|NA P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons MAG.T1.179_00670 1306174.JODP01000001_gene5318 5.1e-284 983.4 Actinobacteria acsA 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 2GJCG@201174,COG0365@1,COG0365@2 NA|NA|NA I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA MAG.T1.179_00671 570268.ANBB01000058_gene4298 3.8e-44 185.3 Streptosporangiales Bacteria 2GIT8@201174,4EG60@85012,COG3177@1,COG3177@2 NA|NA|NA S Filamentation induced by cAMP protein fic MAG.T1.179_00672 1077972.ARGLB_008_01400 2.1e-20 106.7 Micrococcaceae cpaE GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 ko:K04562 ko00000,ko02035 Bacteria 1W9WT@1268,2GIVN@201174,COG0455@1,COG0455@2 NA|NA|NA D bacterial-type flagellum organization MAG.T1.179_00675 110319.CF8_3504 8e-119 434.1 Propionibacteriales 3.4.21.62 ko:K01342 ko02024,map02024 ko00000,ko00001,ko01000,ko01002,ko03110 Bacteria 2GNIX@201174,4DPVM@85009,COG1404@1,COG1404@2 NA|NA|NA O peptidase S8 and S53, subtilisin, kexin, sedolisin MAG.T1.179_00676 477641.MODMU_2499 2.6e-18 98.6 Frankiales Bacteria 2E61P@1,2II66@201174,330QX@2,4ETM0@85013 NA|NA|NA MAG.T1.179_00677 2045.KR76_01335 5.4e-56 224.2 Propionibacteriales ko:K03088 ko00000,ko03021 Bacteria 2GJUI@201174,4DR64@85009,COG1595@1,COG1595@2 NA|NA|NA K Sigma-70 region 2 MAG.T1.179_00678 1429046.RR21198_0487 9.6e-74 284.3 Nocardiaceae gcd Bacteria 2GISM@201174,4FYBJ@85025,COG2133@1,COG2133@2 NA|NA|NA G Glucose / Sorbosone dehydrogenase MAG.T1.179_00680 1510531.JQJJ01000008_gene4215 3.4e-156 558.5 Bradyrhizobiaceae ybaL GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03455 ko00000 2.A.37 Bacteria 1MV34@1224,2TRC5@28211,3JVBN@41294,COG1226@1,COG1226@2,COG4651@1,COG4651@2 NA|NA|NA P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family MAG.T1.179_00681 1033730.CAHG01000004_gene3 2.2e-59 235.3 Propionibacteriales adk 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GJ7T@201174,4DP2T@85009,COG0563@1,COG0563@2 NA|NA|NA F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism MAG.T1.179_00682 266940.Krad_1202 8.2e-08 64.3 Bacteria ko:K15383 ko00000,ko02000 9.A.58.2 Bacteria COG4095@1,COG4095@2 NA|NA|NA S Sugar efflux transporter for intercellular exchange MAG.T1.179_00683 1150399.AQYK01000002_gene2758 1.5e-38 166.0 Microbacteriaceae yaeJ ko:K02835,ko:K15034 ko00000,ko03012 Bacteria 2I7Z4@201174,4FPEN@85023,COG0216@1,COG0216@2 NA|NA|NA J RF-1 domain MAG.T1.179_00685 1171373.PACID_04150 3.3e-08 64.3 Propionibacteriales ko:K00375 ko00000,ko03000 Bacteria 2GITW@201174,4DPHM@85009,COG1167@1,COG1167@2 NA|NA|NA K helix_turn_helix gluconate operon transcriptional repressor MAG.T1.179_00686 1157943.KB892705_gene3044 4.7e-51 208.4 Bacteria cof Bacteria COG0561@1,COG0561@2 NA|NA|NA Q phosphatase activity MAG.T1.179_00687 446466.Cfla_3402 2.4e-228 798.1 Cellulomonadaceae gguA 3.6.3.17 ko:K10545,ko:K10548 ko02010,map02010 M00215,M00216 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2.4,3.A.1.2.5 Bacteria 2GJ3F@201174,4F0KB@85016,COG1129@1,COG1129@2 NA|NA|NA G PFAM ABC transporter related MAG.T1.179_00688 446466.Cfla_3403 7.1e-173 613.6 Cellulomonadaceae gguB GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0016020,GO:0016021,GO:0019321,GO:0031224,GO:0042732,GO:0044238,GO:0044281,GO:0044425,GO:0044464,GO:0071704,GO:0071944 ko:K10547 ko02010,map02010 M00216 ko00000,ko00001,ko00002,ko02000 3.A.1.2.5 Bacteria 2GJAH@201174,4F0VZ@85016,COG4214@1,COG4214@2 NA|NA|NA G Belongs to the binding-protein-dependent transport system permease family MAG.T1.179_00689 1120946.AUBF01000012_gene1136 5.8e-144 517.3 Actinobacteria ko:K10546 ko02010,map02010 M00216 ko00000,ko00001,ko00002,ko02000 3.A.1.2.5 Bacteria 2GKRE@201174,4D5CU@85005,COG4213@1,COG4213@2 NA|NA|NA G Periplasmic binding protein domain MAG.T1.179_00690 675635.Psed_6174 3.5e-169 601.3 Pseudonocardiales fadI GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0003988,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005777,GO:0005782,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0031907,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0032787,GO:0034440,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0055114,GO:0070013,GO:0071704,GO:0072329,GO:0097159,GO:1901363,GO:1901575 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GJI8@201174,4DXSK@85010,COG0183@1,COG0183@2 NA|NA|NA I Belongs to the thiolase family MAG.T1.179_00691 590998.Celf_3120 9.1e-79 300.8 Cellulomonadaceae Bacteria 2HNN0@201174,4F0DD@85016,COG0523@1,COG0523@2 NA|NA|NA S PFAM cobalamin synthesis CobW domain protein MAG.T1.179_00692 436229.JOEH01000004_gene371 1.7e-30 139.0 Streptacidiphilus zur GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010043,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0046872,GO:0046914,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 ko:K02076,ko:K03711,ko:K09823 ko02024,map02024 ko00000,ko00001,ko03000 Bacteria 2IKS3@201174,2NI9X@228398,COG0735@1,COG0735@2 NA|NA|NA P Ferric uptake regulator family MAG.T1.179_00693 526225.Gobs_1602 3.8e-61 241.9 Frankiales scbA ko:K09815 ko02010,map02010 M00242 ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 Bacteria 2GM1K@201174,4ET8X@85013,COG0803@1,COG0803@2 NA|NA|NA P Belongs to the bacterial solute-binding protein 9 family MAG.T1.179_00694 1155718.KB891877_gene5380 1e-30 139.0 Actinobacteria Bacteria 2GKDR@201174,COG0523@1,COG0523@2 NA|NA|NA S cobalamin synthesis CobW domain protein MAG.T1.179_00695 1137271.AZUM01000002_gene3043 1.5e-175 623.2 Pseudonocardiales ko:K06994 ko00000 Bacteria 2GIRQ@201174,4DZH4@85010,COG2409@1,COG2409@2 NA|NA|NA S RND superfamily MAG.T1.179_00696 397278.JOJN01000015_gene3488 2.1e-137 495.4 Propionibacteriales galE1 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 Bacteria 2GMCW@201174,4DP83@85009,COG1087@1,COG1087@2 NA|NA|NA M Polysaccharide biosynthesis protein MAG.T1.179_00697 590998.Celf_1150 3.2e-127 461.8 Cellulomonadaceae galK 2.7.1.6,2.7.7.12 ko:K00849,ko:K00965 ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917 M00362,M00554,M00632 R00955,R01092 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GJXI@201174,4F1TD@85016,COG0153@1,COG0153@2 NA|NA|NA G Belongs to the GHMP kinase family. GalK subfamily MAG.T1.179_00698 979556.MTES_2077 1.2e-270 939.1 Microbacteriaceae 3.2.1.22 ko:K07407 ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603 R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091 RC00049,RC00059,RC00451 ko00000,ko00001,ko01000 Bacteria 2GJJ1@201174,4FKWH@85023,COG3345@1,COG3345@2 NA|NA|NA G Melibiase MAG.T1.179_00699 979556.MTES_2076 1e-73 283.9 Actinobacteria ko:K02529 ko00000,ko03000 Bacteria 2GKFC@201174,COG1609@1,COG1609@2 NA|NA|NA K transcriptional regulator MAG.T1.179_00700 208444.JNYY01000016_gene805 8.2e-84 317.4 Pseudonocardiales Bacteria 2GJBJ@201174,4E2I8@85010,COG1609@1,COG1609@2 NA|NA|NA K Bacterial regulatory proteins, lacI family MAG.T1.179_00701 1032480.MLP_11610 5.3e-46 191.4 Actinobacteria Bacteria 2IFGR@201174,COG2865@1,COG2865@2 NA|NA|NA K Putative DNA-binding domain MAG.T1.179_00702 1219065.VPR01S_05_01810 1.1e-47 196.4 Vibrionales lacA 2.3.1.79 ko:K00661 ko00000,ko01000 Bacteria 1RF1T@1224,1S4DA@1236,1XTJQ@135623,COG0110@1,COG0110@2 NA|NA|NA S COG0110 Acetyltransferase (isoleucine patch superfamily) MAG.T1.179_00703 521674.Plim_2873 6.8e-71 275.0 Planctomycetes mmoQ Bacteria 2IZRQ@203682,COG1639@1,COG1639@2,COG2199@1,COG3706@2 NA|NA|NA T signal transduction protein MAG.T1.179_00704 644283.Micau_0572 9.8e-70 270.8 Micromonosporales yibF Bacteria 2GKJ4@201174,4D8GP@85008,COG5438@1,COG5438@2 NA|NA|NA S YibE F family protein MAG.T1.179_00705 446466.Cfla_1918 1e-59 236.9 Actinobacteria ko:K00241 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002 Bacteria 28HIR@1,2I860@201174,30UAY@2 NA|NA|NA S succinate dehydrogenase MAG.T1.179_00706 446466.Cfla_1917 0.0 1117.4 Cellulomonadaceae sdhA 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ45@201174,4F0MT@85016,COG1053@1,COG1053@2 NA|NA|NA C PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein MAG.T1.179_00707 446466.Cfla_1916 3.4e-111 407.9 Actinobacteria sdhB 1.3.5.1,1.3.5.4 ko:K00240,ko:K00245 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00149,M00150,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJPS@201174,COG0479@1,COG0479@2 NA|NA|NA C succinate dehydrogenase MAG.T1.179_00708 593907.Celgi_2505 1.1e-155 556.6 Actinobacteria efeN ko:K16301 ko00000,ko01000,ko02000 2.A.108.2.3 Bacteria 2GIUB@201174,COG2837@1,COG2837@2 NA|NA|NA P peroxidase MAG.T1.179_00709 446469.Sked_25530 9.4e-137 493.4 Actinobacteria ycdO GO:0000041,GO:0006810,GO:0006811,GO:0006812,GO:0006826,GO:0008150,GO:0015684,GO:0030001,GO:0051179,GO:0051234,GO:0070838,GO:0072511 ko:K07224 ko00000,ko02000 2.A.108.2.3 Bacteria 2GJPY@201174,COG2822@1,COG2822@2,COG4454@1,COG4454@2 NA|NA|NA P periplasmic lipoprotein involved in iron transport MAG.T1.179_00710 1032480.MLP_51570 6.1e-101 374.0 Propionibacteriales ko:K07243 ko00000,ko02000 2.A.108.1,2.A.108.2 Bacteria 2GJ22@201174,4DPYF@85009,COG0672@1,COG0672@2 NA|NA|NA P Iron permease FTR1 family MAG.T1.179_00711 1961.JOAK01000020_gene7292 1.2e-41 177.2 Actinobacteria Bacteria 2GN1H@201174,COG1680@1,COG1680@2 NA|NA|NA V Beta-lactamase MAG.T1.179_00712 512565.AMIS_17490 2.1e-07 63.2 Micromonosporales Bacteria 2GJKC@201174,4DBA8@85008,COG0642@1,COG2205@2 NA|NA|NA T PhoQ Sensor MAG.T1.179_00713 1454010.JEOE01000004_gene180 4.7e-52 211.8 Actinobacteria ko:K02529 ko00000,ko03000 Bacteria 2GQER@201174,COG1609@1,COG1609@2 NA|NA|NA K PFAM regulatory protein LacI MAG.T1.179_00714 196162.Noca_2052 3e-59 235.0 Propionibacteriales 1.5.1.40 ko:K06988 ko00000,ko01000 Bacteria 2GMZ5@201174,4DQQN@85009,COG2085@1,COG2085@2 NA|NA|NA S NADP oxidoreductase coenzyme F420-dependent MAG.T1.179_00715 1298863.AUEP01000004_gene1929 3.6e-59 234.6 Propionibacteriales Bacteria 2GMV1@201174,4DQXT@85009,COG1846@1,COG1846@2 NA|NA|NA K Transcriptional regulator, MarR family MAG.T1.179_00716 369723.Strop_4549 6.3e-26 125.6 Micromonosporales Bacteria 2ATXZ@1,2GN21@201174,31JHI@2,4D910@85008 NA|NA|NA S Glycosyltransferase family 87 MAG.T1.179_00718 1449347.JQLN01000007_gene980 1.1e-49 203.8 Bacteria Bacteria COG4249@1,COG4249@2 NA|NA|NA S B-1 B cell differentiation MAG.T1.179_00719 1116232.AHBF01000163_gene5903 1e-139 504.2 Actinobacteria Bacteria 28N6D@1,2HMGF@201174,2ZBB9@2 NA|NA|NA MAG.T1.179_00720 84531.JMTZ01000014_gene2801 5.5e-152 545.0 Gammaproteobacteria Bacteria 1QVR5@1224,1T2HN@1236,2DBKT@1,2Z9V9@2 NA|NA|NA MAG.T1.179_00721 1121405.dsmv_0678 2.7e-137 496.1 Proteobacteria Bacteria 1RFBU@1224,2C3RM@1,2Z9H1@2 NA|NA|NA MAG.T1.179_00723 84531.JMTZ01000014_gene2798 7.3e-32 145.6 Bacteria Bacteria 2EK9G@1,33DZS@2 NA|NA|NA MAG.T1.179_00724 1121405.dsmv_0684 1.5e-21 111.7 Proteobacteria Bacteria 1NI9Y@1224,2EX2M@1,33QDR@2 NA|NA|NA MAG.T1.179_00725 713586.KB900536_gene1549 1.3e-268 932.2 Chromatiales ilvD 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1259 Bacteria 1MUTQ@1224,1RMP2@1236,1WW0Q@135613,COG0129@1,COG0129@2 NA|NA|NA EG Belongs to the IlvD Edd family MAG.T1.179_00726 1304865.JAGF01000001_gene77 3.6e-60 238.4 Actinobacteria Bacteria 2GTCV@201174,COG1595@1,COG1595@2 NA|NA|NA K Putative zinc-finger MAG.T1.179_00728 1386089.N865_12705 4.4e-35 154.1 Intrasporangiaceae crcB ko:K06199 ko00000,ko02000 1.A.43.1,1.A.43.2,1.A.43.3 Bacteria 2HGGD@201174,4FHJ1@85021,COG0239@1,COG0239@2 NA|NA|NA U Important for reducing fluoride concentration in the cell, thus reducing its toxicity MAG.T1.179_00729 1068978.AMETH_3074 3e-43 181.0 Pseudonocardiales ko:K09137 ko00000 Bacteria 2IM7J@201174,4E77D@85010,COG1993@1,COG1993@2 NA|NA|NA S Uncharacterized ACR, COG1993 MAG.T1.179_00730 1120950.KB892768_gene5293 7.5e-29 133.7 Propionibacteriales crcB2 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 ko:K06199 ko00000,ko02000 1.A.43.1,1.A.43.2,1.A.43.3 Bacteria 2IKM1@201174,4DSBC@85009,COG0239@1,COG0239@2 NA|NA|NA D Important for reducing fluoride concentration in the cell, thus reducing its toxicity MAG.T1.179_00731 1278308.KB907074_gene586 2.8e-38 165.2 Microbacteriaceae Bacteria 2IHZ7@201174,4FNK0@85023,COG0262@1,COG0262@2 NA|NA|NA H RibD C-terminal domain MAG.T1.179_00732 1246448.ANAZ01000044_gene1247 8.5e-82 310.1 Streptosporangiales Bacteria 2GV75@201174,4EK64@85012,COG1309@1,COG1309@2 NA|NA|NA K Tetracyclin repressor, C-terminal all-alpha domain MAG.T1.179_00733 1246448.ANAZ01000005_gene5141 1.9e-106 392.5 Streptosporangiales Bacteria 2GIS3@201174,4EHU0@85012,COG0604@1,COG0604@2 NA|NA|NA C Zinc-binding dehydrogenase MAG.T1.179_00734 593907.Celgi_2506 2.1e-95 355.5 Actinobacteria Bacteria 2GMD7@201174,COG1305@1,COG1305@2 NA|NA|NA E transglutaminase MAG.T1.179_00735 391037.Sare_2910 3.5e-61 241.5 Actinobacteria Bacteria 2C7PT@1,2I886@201174,2ZCBY@2 NA|NA|NA MAG.T1.179_00736 1133849.O3I_037875 3.1e-59 235.3 Nocardiaceae Bacteria 2HH54@201174,4G3S3@85025,COG1309@1,COG1309@2 NA|NA|NA K Tetracyclin repressor, C-terminal all-alpha domain MAG.T1.179_00737 765420.OSCT_0070 2.8e-38 165.6 Chloroflexia Bacteria 28IZQ@1,2GA1E@200795,2Z8X1@2,377NY@32061 NA|NA|NA S Domain of unknown function (DUF4386) MAG.T1.179_00738 526225.Gobs_1399 9.3e-77 293.1 Frankiales ko:K19689 ko00000,ko01000,ko01002 Bacteria 2GJT9@201174,4ETFJ@85013,COG0640@1,COG0640@2 NA|NA|NA K Helix-turn-helix domain MAG.T1.179_00739 1380370.JIBA01000010_gene2372 3.7e-116 424.5 Bacteria Bacteria COG3832@1,COG3832@2 NA|NA|NA J glyoxalase III activity MAG.T1.179_00740 935866.JAER01000004_gene3859 6.6e-36 156.4 Propionibacteriales Bacteria 2E5NA@1,2IQ91@201174,330D3@2,4DRUP@85009 NA|NA|NA S Domain of unknown function (DUF4287) MAG.T1.179_00741 196162.Noca_2810 2.2e-84 318.5 Propionibacteriales MA20_05015 Bacteria 2IHPD@201174,4DWVV@85009,COG0500@1,COG2226@2 NA|NA|NA Q Methyltransferase domain MAG.T1.179_00742 1043205.AFYF01000048_gene2986 3.3e-98 364.8 Intrasporangiaceae Bacteria 2GN74@201174,4FFY8@85021,COG1357@1,COG1357@2 NA|NA|NA S DinB superfamily MAG.T1.179_00744 469383.Cwoe_0617 8.4e-117 426.8 Actinobacteria 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 Bacteria 2I8G2@201174,COG0685@1,COG0685@2 NA|NA|NA E methylenetetrahydrofolate reductase (NAD(P)H) activity MAG.T1.179_00745 66377.JOBH01000001_gene1096 8.9e-96 357.5 Actinobacteria rnhA GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005488,GO:0006139,GO:0006401,GO:0006725,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016891,GO:0016893,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0032296,GO:0033013,GO:0033014,GO:0034641,GO:0034655,GO:0042364,GO:0042578,GO:0043170,GO:0043755,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046700,GO:0051186,GO:0051188,GO:0071667,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576 3.1.26.4,3.1.3.3,3.1.3.73,3.1.3.85,5.4.2.12 ko:K02226,ko:K03469,ko:K06864,ko:K15634,ko:K22305,ko:K22306,ko:K22316 ko00010,ko00260,ko00680,ko00860,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03030,map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01130,map01200,map01230,map03030 M00001,M00002,M00003,M00122 R00582,R01518,R04594,R11173 RC00017,RC00536 ko00000,ko00001,ko00002,ko01000,ko03032 Bacteria 2GJ9R@201174,COG0328@1,COG0328@2,COG0406@1,COG0406@2 NA|NA|NA GL phosphoglycerate mutase MAG.T1.179_00746 58123.JOFJ01000005_gene1472 2.9e-54 218.8 Streptosporangiales ko:K07164 ko00000 Bacteria 2GP84@201174,4EH3Z@85012,COG1579@1,COG1579@2 NA|NA|NA S C4-type zinc ribbon domain MAG.T1.179_00747 2074.JNYD01000014_gene7130 5.1e-114 417.9 Pseudonocardiales yqfO GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.5.4.16 ko:K22391 ko00790,ko01100,map00790,map01100 M00126 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKHZ@201174,4DXZJ@85010,COG0327@1,COG0327@2 NA|NA|NA S PFAM NIF3 (NGG1p interacting factor 3) MAG.T1.179_00748 1380393.JHVP01000005_gene3634 1.3e-103 384.4 Frankiales ko:K07027 ko00000,ko02000 4.D.2 Bacteria 2GMAV@201174,4EU4Q@85013,COG0392@1,COG0392@2 NA|NA|NA S Lysylphosphatidylglycerol synthase TM region MAG.T1.179_00750 1211815.CBYP010000014_gene3463 1.3e-35 157.1 Actinobacteria Bacteria 2CK5M@1,2IQNJ@201174,33W5S@2 NA|NA|NA MAG.T1.179_00751 1304865.JAGF01000001_gene1186 3.6e-162 578.9 Actinobacteria Bacteria 2IAWA@201174,COG2199@1,COG2202@1,COG2202@2,COG3706@2 NA|NA|NA T diguanylate cyclase MAG.T1.179_00752 675635.Psed_2142 1.6e-30 139.0 Pseudonocardiales Bacteria 2B57P@1,2IFRB@201174,31Y1M@2,4E3ZW@85010 NA|NA|NA S Protein of unknown function (DUF3052) MAG.T1.179_00753 477641.MODMU_1853 0.0 1327.0 Frankiales aceE 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2GJRE@201174,4ESAA@85013,COG2609@1,COG2609@2 NA|NA|NA C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) MAG.T1.179_00754 1150864.MILUP08_40902 9.6e-27 127.9 Micromonosporales ko:K18566 ko00332,ko01130,map00332,map01130 R10745,R10746 RC00004,RC00096 ko00000,ko00001,ko01000 Bacteria 2I9GA@201174,4DD5V@85008,COG0454@1,COG0456@2 NA|NA|NA K Acetyltransferase (GNAT) family MAG.T1.179_00755 1283283.ATXA01000038_gene2291 1.3e-63 250.4 Actinobacteria Bacteria 2IAG8@201174,COG3386@1,COG3386@2 NA|NA|NA G PFAM SMP-30 Gluconolaconase MAG.T1.179_00756 1463864.JOGO01000009_gene433 1.6e-51 209.1 Actinobacteria Bacteria 299E4@1,2GM90@201174,2ZWGX@2 NA|NA|NA S Protein of unknown function (DUF3145) MAG.T1.179_00757 1214242.B446_25490 3.6e-74 285.8 Actinobacteria treS 2.4.1.18,2.7.1.175,3.2.1.1,5.4.99.16 ko:K00700,ko:K05343,ko:K16146 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01557,R02108,R02110,R02112,R09945,R11262 RC00002,RC00078,RC01816 ko00000,ko00001,ko00002,ko01000,ko04147 CBM48,GH13 Bacteria 2GKAP@201174,COG3281@1,COG3281@2 NA|NA|NA G protein, probably involved in trehalose biosynthesis MAG.T1.179_00758 1380390.JIAT01000011_gene2397 4.1e-110 405.2 Rubrobacteria Bacteria 2GKWX@201174,4CRXT@84995,COG4097@1,COG4097@2 NA|NA|NA P FAD-binding domain MAG.T1.179_00759 1385518.N798_04100 1.4e-14 86.7 Intrasporangiaceae Bacteria 2GTTI@201174,4FGNQ@85021,COG3976@1,COG3976@2 NA|NA|NA S FMN_bind MAG.T1.179_00760 195250.CM001776_gene2666 1.3e-21 110.9 Synechococcus tir 3.4.11.19 ko:K01266,ko:K07052 ko00000,ko01000,ko01002 Bacteria 1G6D9@1117,1H119@1129,COG1266@1,COG1266@2 NA|NA|NA S CAAX protease self-immunity MAG.T1.179_00762 644548.SCNU_00065 2e-30 140.2 Gordoniaceae Bacteria 2GMMI@201174,4GD92@85026,COG0582@1,COG0582@2 NA|NA|NA L Belongs to the 'phage' integrase family MAG.T1.179_00766 1229781.C272_07005 2.2e-57 228.8 Brevibacteriaceae pdtaR GO:0000160,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0016020,GO:0023052,GO:0030312,GO:0035556,GO:0040007,GO:0043167,GO:0043168,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071944 ko:K22010 M00839 ko00000,ko00002,ko02022 Bacteria 2GK7T@201174,4F9CZ@85019,COG3707@1,COG3707@2 NA|NA|NA T ANTAR MAG.T1.179_00767 196162.Noca_2418 5.1e-40 170.6 Propionibacteriales nusB GO:0008150,GO:0040007 ko:K03625 ko00000,ko03009,ko03021 Bacteria 2IM3D@201174,4DR4N@85009,COG0781@1,COG0781@2 NA|NA|NA K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons MAG.T1.179_00768 1184607.AUCHE_05_06140 1.5e-87 328.9 Dermatophilaceae efp GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02356 ko00000,ko03012 Bacteria 2GJMS@201174,4F6K1@85018,COG0231@1,COG0231@2 NA|NA|NA J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase MAG.T1.179_00769 479432.Sros_6532 3.2e-50 204.5 Streptosporangiales aroQ GO:0003674,GO:0003824,GO:0003855,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:1901576 4.2.1.10 ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 iIT341.HP1038 Bacteria 2IMBY@201174,4EJ73@85012,COG0757@1,COG0757@2 NA|NA|NA E Catalyzes a trans-dehydration via an enolate intermediate MAG.T1.179_00770 471853.Bcav_2021 1.9e-134 485.7 Actinobacteria aroB GO:0003674,GO:0003824,GO:0003856,GO:0005488,GO:0005507,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.71,4.2.3.4 ko:K01735,ko:K13829 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412,R03083 RC00002,RC00078,RC00847 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIUZ@201174,COG0337@1,COG0337@2 NA|NA|NA E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) MAG.T1.179_00771 1996.JOFO01000006_gene481 8.2e-43 180.3 Streptosporangiales aroK GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0019438,GO:0019632,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71,4.2.3.4 ko:K00891,ko:K13829 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412,R03083 RC00002,RC00078,RC00847 ko00000,ko00001,ko00002,ko01000 Bacteria 2GRFW@201174,4EJ4W@85012,COG0703@1,COG0703@2 NA|NA|NA E Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate MAG.T1.179_00772 1120950.KB892708_gene4302 2.7e-155 555.1 Propionibacteriales aroC GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_0976 Bacteria 2GJJN@201174,4DPU4@85009,COG0082@1,COG0082@2 NA|NA|NA E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system MAG.T1.179_00774 266940.Krad_3017 5.1e-08 65.1 Bacteria mshJ ko:K02664,ko:K02665,ko:K12280 ko00000,ko02035,ko02044 Bacteria COG3167@1,COG3167@2 NA|NA|NA NU carbon utilization MAG.T1.179_00775 593907.Celgi_1801 6.1e-17 94.7 Actinobacteria pilN ko:K02663 ko00000,ko02035,ko02044 Bacteria 2IS0C@201174,COG3166@1,COG3166@2 NA|NA|NA NU PFAM Fimbrial assembly family protein MAG.T1.179_00776 1306174.JODP01000013_gene7517 1.3e-68 266.9 Actinobacteria pilM ko:K02662 ko00000,ko02035,ko02044 Bacteria 2IBNF@201174,COG4972@1,COG4972@2 NA|NA|NA NU pilus assembly protein PilM MAG.T1.179_00777 446466.Cfla_1829 2.1e-71 275.8 Cellulomonadaceae hofD 3.4.23.43 ko:K02654 M00331 ko00000,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15.2 Bacteria 2GJ7K@201174,4F1IU@85016,COG1989@1,COG1989@2 NA|NA|NA NOU Type IV leader peptidase family MAG.T1.179_00778 593907.Celgi_1807 1.2e-91 344.4 Actinobacteria Bacteria 2ID24@201174,COG4726@1,COG4726@2 NA|NA|NA NU pilus assembly protein PilW MAG.T1.179_00779 1304865.JAGF01000001_gene3205 7.6e-12 77.8 Actinobacteria Bacteria 2FCR1@1,2H815@201174,344U8@2 NA|NA|NA MAG.T1.179_00780 1048339.KB913029_gene1850 4.2e-38 166.0 Actinobacteria pilV GO:0003674,GO:0005198,GO:0005575,GO:0005623,GO:0008150,GO:0009289,GO:0009405,GO:0009987,GO:0016043,GO:0030030,GO:0042995,GO:0044419,GO:0044464,GO:0051704,GO:0071840 ko:K02457,ko:K02458,ko:K10926,ko:K10930,ko:K10931 ko03070,ko05110,ko05111,map03070,map05110,map05111 M00331 ko00000,ko00001,ko00002,ko02044 3.A.15 Bacteria 2IHD8@201174,COG2165@1,COG2165@2 NA|NA|NA NU general secretion pathway protein MAG.T1.179_00781 1095767.CAHD01000205_gene850 9.5e-18 96.7 Bacteria pilA ko:K02650 ko02020,map02020 ko00000,ko00001,ko02035,ko02044 3.A.15.2 Bacteria COG2165@1,COG2165@2 NA|NA|NA NU general secretion pathway protein MAG.T1.179_00782 1122611.KB903944_gene1165 2e-08 65.9 Streptosporangiales Bacteria 2C5NN@1,2GV7Y@201174,2ZJPF@2,4EKGV@85012 NA|NA|NA MAG.T1.179_00783 935866.JAER01000009_gene774 1.5e-170 606.3 Propionibacteriales fadD3 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 Bacteria 2GIXQ@201174,4DPPW@85009,COG1022@1,COG1022@2 NA|NA|NA I AMP-binding enzyme MAG.T1.179_00784 351607.Acel_1320 2.6e-153 548.5 Frankiales pilC ko:K02653 ko00000,ko02035,ko02044 3.A.15.2 Bacteria 2GQW0@201174,4ERP7@85013,COG1459@1,COG1459@2 NA|NA|NA NU Type II secretion system (T2SS), protein F MAG.T1.179_00785 590998.Celf_2006 1.3e-151 543.1 Actinobacteria pilT ko:K02669 ko00000,ko02035,ko02044 3.A.15.2 Bacteria 2I9GT@201174,COG2805@1,COG2805@2 NA|NA|NA NU twitching motility protein MAG.T1.179_00786 351607.Acel_1322 3.3e-223 781.2 Frankiales pulE ko:K02652 ko00000,ko02035,ko02044 3.A.15.2 Bacteria 2I8C2@201174,4ES0V@85013,COG2804@1,COG2804@2 NA|NA|NA NU General secretory system II, protein E domain protein MAG.T1.179_00787 861299.J421_3061 1.1e-08 68.6 Gemmatimonadetes Bacteria 1ZSPN@142182,COG0457@1,COG0457@2 NA|NA|NA S Domain of unknown function (DUF4388) MAG.T1.179_00788 1210045.ALNP01000016_gene1959 6e-64 251.1 Actinobacteria aroE GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv2552c Bacteria 2GPQQ@201174,COG0169@1,COG0169@2 NA|NA|NA E Shikimate dehydrogenase MAG.T1.179_00789 110319.CF8_1908 6.5e-74 284.6 Propionibacteriales mltG ko:K07082 ko00000 Bacteria 2GKGQ@201174,4DN3K@85009,COG1559@1,COG1559@2 NA|NA|NA S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation MAG.T1.179_00790 28444.JODQ01000017_gene6586 2.9e-41 174.9 Streptosporangiales yqgF GO:0000966,GO:0000967,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0140097,GO:1901360 ko:K07447 ko00000,ko01000 Bacteria 2IQB0@201174,4EJ6B@85012,COG0816@1,COG0816@2 NA|NA|NA L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA MAG.T1.179_00791 1048339.KB913029_gene3957 0.0 1090.5 Frankiales alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 2GIUG@201174,4ERRJ@85013,COG0013@1,COG0013@2 NA|NA|NA J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain MAG.T1.179_00793 365528.KB891218_gene1492 1e-153 550.1 Frankiales rarA ko:K07478 ko00000 Bacteria 2GKDP@201174,4ERXK@85013,COG2256@1,COG2256@2 NA|NA|NA L AAA ATPase, central domain protein MAG.T1.179_00794 1033730.CAHG01000016_gene542 1.8e-29 137.1 Propionibacteriales Bacteria 28MY8@1,2GMYY@201174,2ZB54@2,4DNCX@85009 NA|NA|NA MAG.T1.179_00795 1041522.MCOL_V218443 1.6e-110 407.1 Mycobacteriaceae copD ko:K02351,ko:K07245 ko00000,ko02000 9.B.62.1 Bacteria 233IV@1762,2GKIR@201174,COG3336@1,COG3336@2 NA|NA|NA P CytoChrome c oxidase Caa3 assembly factor MAG.T1.179_00796 1268303.RHODMAR_0244 6.7e-20 104.4 Nocardiaceae copC ko:K07156 ko00000,ko02000 9.B.62.2 Bacteria 2GMKG@201174,4FYGB@85025,COG2372@1,COG2372@2 NA|NA|NA S CopC domain MAG.T1.179_00797 405948.SACE_2041 7.6e-255 886.3 Pseudonocardiales aspS GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 Bacteria 2GJHU@201174,4E0SI@85010,COG0173@1,COG0173@2 NA|NA|NA J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) MAG.T1.179_00798 1033730.CAHG01000016_gene574 3.1e-163 581.6 Propionibacteriales hisS 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 2GIYJ@201174,4DP1N@85009,COG0124@1,COG0124@2 NA|NA|NA J Histidine--tRNA ligase MAG.T1.179_00799 935866.JAER01000015_gene1674 7.2e-76 290.4 Propionibacteriales ycbL 3.1.2.6 ko:K01069 ko00620,map00620 R01736 RC00004,RC00137 ko00000,ko00001,ko01000 Bacteria 2GJU0@201174,4DNMS@85009,COG0491@1,COG0491@2 NA|NA|NA S Metallo-beta-lactamase superfamily MAG.T1.179_00800 1504319.GM45_5185 3.1e-54 218.8 unclassified Actinobacteria (class) 5.2.1.8 ko:K01802,ko:K03768 ko00000,ko01000,ko03110 Bacteria 2GN8G@201174,3UWKX@52018,COG0652@1,COG0652@2 NA|NA|NA O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides MAG.T1.179_00801 1894.JOER01000023_gene7347 8.7e-88 330.9 Actinobacteria Bacteria 2GJBD@201174,COG1196@1,COG1196@2 NA|NA|NA D Domain of Unknown Function (DUF349) MAG.T1.179_00802 351607.Acel_1338 1.7e-299 1035.0 Frankiales relA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009259,GO:0009260,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0015969,GO:0015970,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034035,GO:0034036,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042578,GO:0042594,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044419,GO:0044464,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051704,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 Bacteria 2GJYQ@201174,4EREV@85013,COG0317@1,COG0317@2 NA|NA|NA KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance MAG.T1.179_00803 1120950.KB892708_gene4278 2.3e-93 349.4 Propionibacteriales secF GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 ko:K03072,ko:K03074,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 Bacteria 2GJRS@201174,4DPBJ@85009,COG0341@1,COG0341@2 NA|NA|NA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA MAG.T1.179_00804 1504319.GM45_5165 3e-115 422.5 unclassified Actinobacteria (class) secD GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 ko:K03072,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 Bacteria 2GJTT@201174,3UWKE@52018,COG0342@1,COG0342@2 NA|NA|NA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA MAG.T1.179_00805 570268.ANBB01000054_gene4590 1.1e-139 503.1 Streptosporangiales ruvB GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 3.6.4.12 ko:K03551 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 2GJZF@201174,4EH70@85012,COG2255@1,COG2255@2 NA|NA|NA L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing MAG.T1.179_00806 1120950.KB892708_gene4274 4.9e-52 211.1 Propionibacteriales ruvA GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 ko:K03550 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 2GN17@201174,4DQ7Y@85009,COG0632@1,COG0632@2 NA|NA|NA L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB MAG.T1.179_00807 471852.Tcur_2109 3.9e-51 208.0 Streptosporangiales ruvC GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 ko:K01159 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 2GJI5@201174,4EIKP@85012,COG0817@1,COG0817@2 NA|NA|NA L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group MAG.T1.179_00808 557599.MKAN_09615 3.1e-93 349.4 Mycobacteriaceae Bacteria 235TY@1762,2GKU0@201174,COG1020@1,COG1020@2 NA|NA|NA Q Diacylglycerol O-acyltransferase MAG.T1.179_00809 269800.Tfu_2096 3.7e-110 404.4 Streptosporangiales yebC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 Bacteria 2GJ4G@201174,4EGE0@85012,COG0217@1,COG0217@2 NA|NA|NA K Transcriptional regulator MAG.T1.179_00810 1463887.KL589984_gene3407 5.7e-69 267.3 Actinobacteria pdxT GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0071496,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600 4.3.3.6 ko:K08681 ko00750,map00750 R07456 RC00010,RC01783,RC03043 ko00000,ko00001,ko01000 iHN637.CLJU_RS19495 Bacteria 2GNYG@201174,COG0311@1,COG0311@2 NA|NA|NA H Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS MAG.T1.179_00811 1206735.BAGG01000085_gene3482 1.2e-22 111.7 Nocardiaceae pdxS GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0040007,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 4.3.3.6 ko:K06215 ko00750,map00750 R07456 RC00010,RC01783,RC03043 ko00000,ko00001,ko01000 Bacteria 2GK1T@201174,4FTYJ@85025,COG0214@1,COG0214@2 NA|NA|NA H Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively MAG.T1.179_00814 1120936.KB907223_gene2469 3.4e-58 232.3 Streptosporangiales yerB Bacteria 2GP8D@201174,4EGFU@85012,COG1470@1,COG1470@2 NA|NA|NA S Protein of unknown function (DUF3048) C-terminal domain MAG.T1.179_00815 1157637.KB892156_gene4020 3.6e-38 164.9 Actinobacteria ko:K03744 ko00000 Bacteria 2GK54@201174,COG1704@1,COG1704@2 NA|NA|NA L nUDIX hydrolase MAG.T1.179_00816 1169161.KB897725_gene1738 1.7e-117 429.5 Actinobacteria pimA GO:0000026,GO:0000030,GO:0000287,GO:0003674,GO:0003824,GO:0004376,GO:0004377,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006644,GO:0006650,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0043167,GO:0043169,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046486,GO:0046488,GO:0046872,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.4.1.345 ko:K08256 R11702 ko00000,ko01000,ko01003 GT4 Bacteria 2GKQ8@201174,COG0438@1,COG0438@2 NA|NA|NA M PFAM Glycosyl transferase, group 1 MAG.T1.179_00817 566461.SSFG_05851 5.2e-82 311.2 Actinobacteria htrB GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.3.1.241,2.3.1.265 ko:K02517,ko:K22311 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 Bacteria 2GM7B@201174,COG1560@1,COG1560@2 NA|NA|NA M Lipid A biosynthesis MAG.T1.179_00818 1089455.MOPEL_021_00590 2e-43 182.6 Dermatophilaceae pgsA1 GO:0003674,GO:0003824,GO:0003881,GO:0003882,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.7.8.11,2.7.8.5 ko:K00995,ko:K00999 ko00562,ko00564,ko01100,ko04070,map00562,map00564,map01100,map04070 R01801,R01802 RC00002,RC00017,RC00078,RC02795 ko00000,ko00001,ko01000 Bacteria 2GYKW@201174,4F6UB@85018,COG0558@1,COG0558@2 NA|NA|NA I CDP-alcohol phosphatidyltransferase MAG.T1.179_00819 479433.Caci_2340 2.9e-288 997.7 Actinobacteria fusA2 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0030312,GO:0044237,GO:0044464,GO:0071944 ko:K02355 ko00000,ko03012,ko03029 Bacteria 2GKRU@201174,COG0480@1,COG0480@2 NA|NA|NA J elongation factor G MAG.T1.179_00820 711393.AYRX01000031_gene269 1e-38 166.4 Actinobacteria Bacteria 2IFBJ@201174,COG2050@1,COG2050@2 NA|NA|NA Q Domain of unknown function (DUF4442) MAG.T1.179_00821 44060.JODL01000004_gene2457 3.6e-38 164.9 Actinobacteria Bacteria 2IFC7@201174,COG5083@1,COG5083@2 NA|NA|NA S phosphatidylinositol transporter activity MAG.T1.179_00822 471852.Tcur_2429 0.0 1225.7 Streptosporangiales gcvP GO:0003674,GO:0003824,GO:0004375,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016638,GO:0016642,GO:0030312,GO:0040007,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944 1.4.4.2 ko:K00281,ko:K00282 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 iECIAI39_1322.ECIAI39_3318 Bacteria 2GJ11@201174,4EI8D@85012,COG0403@1,COG0403@2,COG1003@1,COG1003@2 NA|NA|NA E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor MAG.T1.179_00823 1095767.CAHD01000209_gene127 5e-67 260.8 Cellulomonadaceae merR2 Bacteria 2GM67@201174,4F16V@85016,COG0789@1,COG0789@2 NA|NA|NA K helix_turn_helix, mercury resistance MAG.T1.179_00824 1449346.JQMO01000003_gene3002 2e-40 172.2 Kitasatospora GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 ko:K03617,ko:K08999 ko00000 Bacteria 2GN26@201174,2M26I@2063,COG1259@1,COG1259@2 NA|NA|NA S Bifunctional nuclease MAG.T1.179_00825 1120950.KB892707_gene5034 8.9e-64 250.4 Propionibacteriales merR1 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 Bacteria 2HBV6@201174,4DQDI@85009,COG0789@1,COG0789@2 NA|NA|NA K helix_turn_helix, mercury resistance MAG.T1.179_00826 570268.ANBB01000003_gene540 1.8e-36 159.1 Streptosporangiales Bacteria 2GK99@201174,4EJ30@85012,COG1716@1,COG1716@2 NA|NA|NA T Inner membrane component of T3SS, cytoplasmic domain MAG.T1.179_00827 222534.KB893671_gene3398 2.2e-37 161.8 Frankiales gcvH ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 iNJ661.Rv1826 Bacteria 2IKN2@201174,4ESYX@85013,COG0509@1,COG0509@2 NA|NA|NA E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein MAG.T1.179_00828 1385518.N798_07750 1.2e-37 163.7 Intrasporangiaceae GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 Bacteria 2GJ3C@201174,4FEXI@85021,COG3879@1,COG3879@2 NA|NA|NA S Bacterial protein of unknown function (DUF881) MAG.T1.179_00829 1306174.JODP01000002_gene5961 1.7e-35 155.2 Actinobacteria sbp Bacteria 2IKJW@201174,COG3856@1,COG3856@2 NA|NA|NA S conserved protein (small basic protein) MAG.T1.179_00830 479433.Caci_3123 1.2e-27 130.6 Actinobacteria GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 Bacteria 2GMS5@201174,COG3879@1,COG3879@2 NA|NA|NA S protein conserved in bacteria MAG.T1.179_00831 58123.JOFJ01000007_gene696 1e-281 976.1 Streptosporangiales mpg 1.6.5.5,2.7.7.13,5.4.2.10,5.4.2.2,5.4.2.8 ko:K00344,ko:K00966,ko:K01840,ko:K03431,ko:K15778,ko:K16881 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114,M00361,M00362 R00885,R00959,R01057,R01818,R02060,R08639 RC00002,RC00408 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_3178 Bacteria 2GKTE@201174,4EFSZ@85012,COG1109@1,COG1109@2,COG1208@1,COG1208@2 NA|NA|NA GJM Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III MAG.T1.179_00832 1171373.PACID_16570 2.2e-49 202.2 Propionibacteriales pgsA GO:0003674,GO:0003824,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 Bacteria 2GM3F@201174,4DQ8M@85009,COG0558@1,COG0558@2 NA|NA|NA I Belongs to the CDP-alcohol phosphatidyltransferase class-I family MAG.T1.179_00833 269800.Tfu_0590 5.4e-75 287.7 Streptosporangiales echA17 GO:0003674,GO:0003824,GO:0004300,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJW5@201174,4EH13@85012,COG1024@1,COG1024@2 NA|NA|NA I Enoyl-CoA hydratase/isomerase MAG.T1.179_00834 1123320.KB889709_gene8414 8.8e-266 922.9 Actinobacteria glgX 3.2.1.196,3.2.1.68 ko:K01214,ko:K02438 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02111,R09995,R11261 ko00000,ko00001,ko00002,ko01000 CBM48,GH13 Bacteria 2GJ00@201174,COG1523@1,COG1523@2 NA|NA|NA G Belongs to the glycosyl hydrolase 13 family MAG.T1.179_00835 471852.Tcur_3583 3.8e-210 738.0 Streptosporangiales glgE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.4.99.16 ko:K16147 ko00500,ko01100,map00500,map01100 R09994 ko00000,ko00001,ko01000 GH13 Bacteria 2GJKR@201174,4EG8Q@85012,COG0366@1,COG0366@2 NA|NA|NA G Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB MAG.T1.179_00836 1120950.KB892798_gene2193 0.0 1080.5 Propionibacteriales glgB GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0071704,GO:1901576 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 ko00000,ko00001,ko00002,ko01000,ko04147 CBM48,GH13 Bacteria 2GJ5C@201174,4DPZS@85009,COG0296@1,COG0296@2 NA|NA|NA G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position MAG.T1.179_00837 1306174.JODP01000018_gene4385 2.5e-71 275.8 Actinobacteria trxA2 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 ko:K03671,ko:K05838 ko04621,ko05418,map04621,map05418 ko00000,ko00001,ko03110 Bacteria 2GJ7B@201174,COG3118@1,COG3118@2 NA|NA|NA O Thioredoxin MAG.T1.179_00838 1289387.AUKW01000008_gene4681 7.3e-215 753.4 Actinobacteria icmA 5.4.99.2 ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 Bacteria 2GM65@201174,COG1884@1,COG1884@2 NA|NA|NA I Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly MAG.T1.179_00839 1894.JOER01000007_gene6468 5.8e-108 397.5 Actinobacteria ko:K07588 ko00000,ko01000 Bacteria 2GME8@201174,COG1703@1,COG1703@2 NA|NA|NA E LAO AO transport system ATPase MAG.T1.179_00840 345341.KUTG_06459 2.4e-167 595.1 Pseudonocardiales fadA4 GO:0003674,GO:0003824,GO:0003988,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044403,GO:0044419,GO:0044464,GO:0046395,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:0075136,GO:1901575 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GJAC@201174,4DYM7@85010,COG0183@1,COG0183@2 NA|NA|NA I Belongs to the thiolase family MAG.T1.179_00841 1048339.KB913029_gene3420 1.7e-49 202.2 Frankiales mce 5.1.99.1 ko:K05606 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R02765,R09979 RC00780,RC02739 ko00000,ko00001,ko00002,ko01000 Bacteria 2IIPR@201174,4ESUP@85013,COG0346@1,COG0346@2 NA|NA|NA E PFAM Glyoxalase bleomycin resistance protein dioxygenase MAG.T1.179_00842 44060.JODL01000020_gene4906 4.9e-214 750.4 Actinobacteria 1.3.1.86 ko:K17829 ko00650,ko01120,ko01130,ko01200,map00650,map01120,map01130,map01200 R09738 RC00076 ko00000,ko00001,ko01000 Bacteria 2GKFF@201174,COG0604@1,COG0604@2 NA|NA|NA C reductase MAG.T1.179_00843 743718.Isova_2618 5e-143 514.6 Promicromonosporaceae otsA GO:0003674,GO:0003824,GO:0003825,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016311,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0016788,GO:0016791,GO:0030145,GO:0030312,GO:0033554,GO:0034637,GO:0035251,GO:0040007,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046527,GO:0046872,GO:0046914,GO:0047260,GO:0050896,GO:0051716,GO:0070413,GO:0071704,GO:0071944,GO:1901576 2.4.1.15,2.4.1.347,3.1.3.12 ko:K00697,ko:K16055 ko00500,ko01100,map00500,map01100 R02737,R02778 RC00005,RC00017,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 GT20 Bacteria 2GMX7@201174,4F40E@85017,COG0380@1,COG0380@2 NA|NA|NA G Glycosyltransferase family 20 MAG.T1.179_00844 1341646.CBMO010000130_gene3119 8.9e-40 170.6 Mycobacteriaceae otsB GO:0000287,GO:0003674,GO:0003824,GO:0004805,GO:0005488,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0009058,GO:0009266,GO:0009311,GO:0009312,GO:0009409,GO:0009628,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0033554,GO:0034637,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0046351,GO:0046872,GO:0050896,GO:0051716,GO:0070413,GO:0070415,GO:0070417,GO:0071704,GO:1901576 2.4.1.15,2.4.1.347,3.1.3.12 ko:K00697,ko:K01087,ko:K16055 ko00500,ko01100,map00500,map01100 R02737,R02778 RC00005,RC00017,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 GT20 iE2348C_1286.E2348C_2018,iECED1_1282.ECED1_2163,iECIAI39_1322.ECIAI39_1155,iECS88_1305.ECS88_1952,iLF82_1304.LF82_1582,iNRG857_1313.NRG857_09495 Bacteria 233CH@1762,2I3PZ@201174,COG1877@1,COG1877@2 NA|NA|NA G Removes the phosphate from trehalose 6-phosphate to produce free trehalose MAG.T1.179_00845 1122611.KB903996_gene7554 8.7e-57 227.3 Streptosporangiales pcaD Bacteria 2GNFU@201174,4EFFN@85012,COG0596@1,COG0596@2 NA|NA|NA S Serine aminopeptidase, S33 MAG.T1.179_00846 446470.Snas_1605 5.5e-23 113.2 Glycomycetales Bacteria 2E3EP@1,2GQST@201174,32YDP@2,4EZ3F@85014 NA|NA|NA S ATP- GTP-binding protein MAG.T1.179_00847 33876.JNXY01000008_gene8430 4.4e-74 284.6 Micromonosporales ko:K07018 ko00000 Bacteria 2GP8G@201174,4DCBM@85008,COG2945@1,COG2945@2 NA|NA|NA S hydrolase of the alpha beta MAG.T1.179_00848 1380370.JIBA01000014_gene2048 2.9e-217 761.5 Intrasporangiaceae 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 Bacteria 2GJBM@201174,4FEPZ@85021,COG1250@1,COG1250@2 NA|NA|NA I Dehydrogenase MAG.T1.179_00849 477641.MODMU_4528 4e-95 354.4 Frankiales nucS ko:K07503 ko00000,ko01000 Bacteria 2GIYB@201174,4ES1R@85013,COG1637@1,COG1637@2 NA|NA|NA L Cleaves both 3' and 5' ssDNA extremities of branched DNA structures MAG.T1.179_00850 1211815.CBYP010000045_gene812 2.6e-99 368.6 Frankiales ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GJBF@201174,4EUKR@85013,COG1131@1,COG1131@2 NA|NA|NA V AAA domain, putative AbiEii toxin, Type IV TA system MAG.T1.179_00851 1454010.JEOE01000017_gene1266 8e-74 283.9 Cellulomonadaceae ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GN6S@201174,4F0I9@85016,COG0842@1,COG0842@2 NA|NA|NA V PFAM ABC-2 type transporter MAG.T1.179_00852 1894.JOER01000032_gene6102 1.4e-235 822.4 Actinobacteria meaA 5.4.99.2,5.4.99.63 ko:K01847,ko:K01849,ko:K14447 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R00833,R09292 RC00395,RC02835 ko00000,ko00001,ko00002,ko01000 Bacteria 2I2N3@201174,COG2185@1,COG2185@2 NA|NA|NA I Methylmalonyl-CoA mutase MAG.T1.179_00853 1123052.AUDF01000002_gene687 1.1e-21 110.2 Microbacteriaceae Bacteria 2B212@1,2HTBX@201174,31UHT@2,4FSXA@85023 NA|NA|NA MAG.T1.179_00855 710111.FraQA3DRAFT_3461 7e-25 120.6 Actinobacteria ko:K03088 ko00000,ko03021 Bacteria 2IKVM@201174,COG1595@1,COG1595@2 NA|NA|NA K belongs to the sigma-70 factor family, ECF subfamily MAG.T1.179_00856 1217658.F987_02722 8.4e-16 91.7 Moraxellaceae Bacteria 1QVSC@1224,1SRBM@1236,3NR5W@468,COG3979@1,COG3979@2 NA|NA|NA S chitinase MAG.T1.179_00857 1146883.BLASA_1786 1.8e-208 731.9 Frankiales Bacteria 2GJK7@201174,4ES3E@85013,COG3464@1,COG3464@2 NA|NA|NA L PFAM transposase IS204 IS1001 IS1096 IS1165 family protein MAG.T1.179_00858 710696.Intca_3499 1.5e-158 565.8 Intrasporangiaceae Bacteria 2GS79@201174,4FFP0@85021,COG3547@1,COG3547@2 NA|NA|NA L Transposase MAG.T1.179_00859 710696.Intca_3502 9.2e-30 136.3 Intrasporangiaceae 2.3.1.15 ko:K08591,ko:K19159 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004,ko02048 Bacteria 2GRC8@201174,4FJ8S@85021,COG2161@1,COG2161@2 NA|NA|NA D Antitoxin component of a toxin-antitoxin (TA) module MAG.T1.179_00860 710696.Intca_3501 4e-33 147.1 Intrasporangiaceae ko:K06218 ko00000,ko02048 Bacteria 2GRQR@201174,4FJ7R@85021,COG2026@1,COG2026@2 NA|NA|NA DJ ParE toxin of type II toxin-antitoxin system, parDE MAG.T1.179_00861 1146883.BLASA_1786 1.8e-208 731.9 Frankiales Bacteria 2GJK7@201174,4ES3E@85013,COG3464@1,COG3464@2 NA|NA|NA L PFAM transposase IS204 IS1001 IS1096 IS1165 family protein MAG.T1.179_00862 710696.Intca_3499 1.5e-158 565.8 Intrasporangiaceae Bacteria 2GS79@201174,4FFP0@85021,COG3547@1,COG3547@2 NA|NA|NA L Transposase MAG.T1.179_00863 1184609.KILIM_005_00340 8.4e-153 547.0 Actinobacteria Bacteria 2GM8F@201174,COG3328@1,COG3328@2 NA|NA|NA L Transposase MAG.T1.179_00864 525368.HMPREF0591_1854 8.8e-100 370.2 Mycobacteriaceae Bacteria 2374G@1762,2I9ZX@201174,COG4974@1,COG4974@2 NA|NA|NA L Belongs to the 'phage' integrase family MAG.T1.179_00865 557599.MKAN_02490 2.7e-213 748.4 Mycobacteriaceae ko:K03733,ko:K04763 ko00000,ko03036 Bacteria 236NP@1762,2IBD6@201174,COG4974@1,COG4974@2 NA|NA|NA L Belongs to the 'phage' integrase family MAG.T1.179_00867 1120944.JONS01000036_gene2549 1.1e-20 105.9 Actinobacteria Bacteria 2GJV7@201174,4D5Q7@85005,COG1609@1,COG1609@2 NA|NA|NA K Periplasmic binding protein domain MAG.T1.179_00869 1123229.AUBC01000025_gene4510 1.8e-19 102.1 Bradyrhizobiaceae Bacteria 1RJ9E@1224,2AF64@1,2U9GE@28211,3154Z@2,3K5A6@41294 NA|NA|NA S Protein of unknown function (DUF2384) MAG.T1.179_00871 1240349.ANGC01000009_gene2758 2.7e-70 272.3 Actinobacteria Bacteria 2ICPM@201174,COG0589@1,COG0589@2 NA|NA|NA T universal stress protein MAG.T1.179_00872 1122149.BACN01000019_gene712 1.7e-07 63.2 Lactobacillaceae greA ko:K03624,ko:K04760 ko00000,ko03021 Bacteria 1V1G3@1239,3F6ZK@33958,4HW8H@91061,COG0782@1,COG0782@2 NA|NA|NA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides MAG.T1.179_00873 644283.Micau_2658 4.6e-128 464.5 Micromonosporales Bacteria 2GRBZ@201174,4DH16@85008,COG3835@1,COG3835@2 NA|NA|NA KT PucR C-terminal helix-turn-helix domain MAG.T1.179_00874 548479.HMPREF0573_10529 2.6e-08 65.5 Actinobacteria 3.6.3.17 ko:K10441 ko02010,map02010 M00212 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 Bacteria 2GJDV@201174,4D5BM@85005,COG1129@1,COG1129@2 NA|NA|NA G ATPases associated with a variety of cellular activities MAG.T1.179_00875 710696.Intca_1166 1.5e-100 372.9 Actinobacteria 2.7.1.15 ko:K00852 ko00030,map00030 R01051,R02750 RC00002,RC00017 ko00000,ko00001,ko01000 Bacteria 2GP1C@201174,COG0524@1,COG0524@2 NA|NA|NA G Belongs to the carbohydrate kinase PfkB family MAG.T1.179_00876 710696.Intca_1165 6.4e-112 410.6 Intrasporangiaceae psuG GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0019200,GO:0044237,GO:0044238,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046835,GO:0071704 4.2.1.70 ko:K16329 ko00240,map00240 R01055 RC00432,RC00433 ko00000,ko00001,ko01000 Bacteria 2GK19@201174,4FEJH@85021,COG2313@1,COG2313@2 NA|NA|NA Q Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway MAG.T1.179_00877 710696.Intca_1164 3.4e-65 255.4 Bacteria Bacteria COG0583@1,COG0583@2 NA|NA|NA K DNA-binding transcription factor activity MAG.T1.179_00879 1095769.CAHF01000025_gene693 1.6e-204 718.8 Oxalobacteraceae gdhA GO:0003674,GO:0003824,GO:0004353,GO:0004354,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.3,1.4.1.4 ko:K00261,ko:K00262 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1MUMF@1224,2VIZ7@28216,472NR@75682,COG0334@1,COG0334@2 NA|NA|NA E Glutamate/Leucine/Phenylalanine/Valine dehydrogenase MAG.T1.179_00880 1232410.KI421412_gene16 3.6e-269 934.5 Desulfuromonadales 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 Bacteria 1N38V@1224,2WKAZ@28221,42MWC@68525,43SUV@69541,COG0574@1,COG0574@2 NA|NA|NA G Pyruvate phosphate dikinase, PEP/pyruvate binding domain MAG.T1.179_00881 1122138.AQUZ01000033_gene3629 1.6e-83 316.6 Propionibacteriales lppS GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016787,GO:0017171,GO:0018104,GO:0019538,GO:0030203,GO:0030312,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044464,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 Bacteria 2GJBA@201174,4DN7Y@85009,COG1376@1,COG1376@2 NA|NA|NA S L,D-transpeptidase catalytic domain MAG.T1.179_00882 1193181.BN10_900020 3e-11 73.9 Intrasporangiaceae fieF Bacteria 2GJ8Q@201174,4FE8E@85021,COG0053@1,COG0053@2 NA|NA|NA P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family MAG.T1.179_00884 926569.ANT_00100 5.7e-54 217.6 Chloroflexi sdpI Bacteria 2G714@200795,COG5658@1,COG5658@2 NA|NA|NA S SdpI/YhfL protein family MAG.T1.179_00885 1429046.RR21198_2521 5.5e-160 570.9 Nocardiaceae Bacteria 2GM4J@201174,4FY11@85025,COG4584@1,COG4584@2 NA|NA|NA L Transposase MAG.T1.179_00886 1268303.RHODMAR_4992 8.1e-100 370.2 Nocardiaceae Bacteria 2H714@201174,4FXQJ@85025,COG1484@1,COG1484@2 NA|NA|NA L IstB-like ATP binding protein MAG.T1.179_00889 1173027.Mic7113_0392 7.3e-42 178.3 Cyanobacteria pslG ko:K21000 ko02025,map02025 ko00000,ko00001 GH39 Bacteria 1GANI@1117,COG3664@1,COG3664@2 NA|NA|NA G PFAM Glycosyl hydrolases family 39 MAG.T1.179_00890 1173027.Mic7113_0392 2.8e-37 163.3 Cyanobacteria pslG ko:K21000 ko02025,map02025 ko00000,ko00001 GH39 Bacteria 1GANI@1117,COG3664@1,COG3664@2 NA|NA|NA G PFAM Glycosyl hydrolases family 39 MAG.T1.179_00891 1211815.CBYP010000024_gene1543 1.6e-122 446.0 Actinobacteria rgpA ko:K12996 ko00000,ko01000,ko01003,ko01005 GT4 Bacteria 2IBM0@201174,COG0438@1,COG0438@2 NA|NA|NA M Glycosyltransferase MAG.T1.179_00892 110319.CF8_3325 4.4e-35 156.4 Bacteria 2.1.1.107,2.1.1.294,2.7.1.181,2.7.11.1 ko:K02496,ko:K05802,ko:K08884,ko:K18827 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03194,R10657,R10658 RC00002,RC00003,RC00078,RC00871,RC03220 ko00000,ko00001,ko00002,ko01000,ko01001,ko01005,ko02000 1.A.23.1.1 Bacteria COG2959@1,COG2959@2 NA|NA|NA H enzyme of heme biosynthesis MAG.T1.179_00893 263358.VAB18032_22820 2.7e-63 249.2 Micromonosporales wbbL_1 ko:K07011 ko00000 Bacteria 2HEV5@201174,4D9DN@85008,COG1216@1,COG1216@2 NA|NA|NA S Glycosyl transferase family group 2 MAG.T1.179_00894 367299.JOEE01000003_gene3004 1.4e-72 280.8 Actinobacteria Bacteria 2IT2M@201174,COG1807@1,COG1807@2 NA|NA|NA M Dolichyl-phosphate-mannose-protein mannosyltransferase MAG.T1.179_00895 1304865.JAGF01000001_gene119 3.4e-155 555.4 Actinobacteria yvnB 3.1.4.53 ko:K03651 ko00230,ko02025,map00230,map02025 R00191 RC00296 ko00000,ko00001,ko01000 Bacteria 2GN7G@201174,COG1409@1,COG1409@2,COG3291@1,COG3291@2 NA|NA|NA P PFAM PKD domain containing protein MAG.T1.179_00896 1136417.AZWE01000070_gene1255 9.9e-76 290.8 Micromonosporales GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0015562,GO:0022857,GO:0042221,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0055085 Bacteria 2HB3P@201174,4DCV1@85008,COG2271@1,COG2271@2 NA|NA|NA G PFAM major facilitator superfamily MFS_1 MAG.T1.179_00897 931627.MycrhDRAFT_2921 1.4e-242 845.9 Mycobacteriaceae fimV_2 ko:K19719 ko04151,ko04510,ko04512,ko04974,ko05165,map04151,map04510,map04512,map04974,map05165 ko00000,ko00001,ko00536 Bacteria 232WS@1762,2GJ7M@201174,COG0247@1,COG0247@2,COG3266@1,COG3266@2 NA|NA|NA C Fe-S oxidoreductase MAG.T1.179_00898 1123322.KB904702_gene229 6.1e-263 913.3 Actinobacteria dnaK ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 Bacteria 2GJTY@201174,COG0443@1,COG0443@2 NA|NA|NA O Heat shock 70 kDa protein MAG.T1.179_00899 351607.Acel_2116 9.4e-41 173.7 Frankiales grpE GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0007154,GO:0008150,GO:0009266,GO:0009267,GO:0009408,GO:0009605,GO:0009628,GO:0009986,GO:0009987,GO:0009991,GO:0016043,GO:0017076,GO:0019904,GO:0022607,GO:0030234,GO:0030246,GO:0030247,GO:0030312,GO:0030554,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0033554,GO:0036094,GO:0040007,GO:0042594,GO:0042802,GO:0042803,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0050790,GO:0050896,GO:0051082,GO:0051716,GO:0060589,GO:0060590,GO:0065003,GO:0065007,GO:0065009,GO:0071496,GO:0071840,GO:0071944,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065 ko:K02652,ko:K03687 ko00000,ko02035,ko02044,ko03029,ko03110 3.A.15.2 Bacteria 2GP4F@201174,4ESWP@85013,COG0576@1,COG0576@2 NA|NA|NA O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ MAG.T1.179_00900 1122611.KB903952_gene6087 6.6e-109 401.0 Streptosporangiales dnaJ GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0010468,GO:0016020,GO:0019222,GO:0030312,GO:0040007,GO:0043388,GO:0044093,GO:0044464,GO:0050789,GO:0051098,GO:0051099,GO:0051101,GO:0060255,GO:0065007,GO:0065009,GO:0071944,GO:2000677,GO:2000679 ko:K03686,ko:K05516 ko00000,ko03029,ko03036,ko03110 Bacteria 2GJKK@201174,4EHSG@85012,COG0484@1,COG0484@2 NA|NA|NA O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins MAG.T1.179_00901 31964.CMS2809 6.6e-27 126.7 Microbacteriaceae hspR ko:K13640 ko00000,ko03000 Bacteria 2IQJ4@201174,4FP4F@85023,COG0789@1,COG0789@2 NA|NA|NA K helix_turn_helix, mercury resistance MAG.T1.179_00902 436229.JOEH01000017_gene6930 0.0 1198.7 Streptacidiphilus clpB GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 ko:K03694,ko:K03695 ko04213,map04213 ko00000,ko00001,ko03110 Bacteria 2GJ73@201174,2NGRH@228398,COG0542@1,COG0542@2 NA|NA|NA O C-terminal, D2-small domain, of ClpB protein MAG.T1.179_00903 1896.JOAU01000009_gene6381 7.3e-47 193.4 Actinobacteria osmC ko:K04063 ko00000 Bacteria 2IFFB@201174,COG1764@1,COG1764@2 NA|NA|NA O PFAM OsmC family protein MAG.T1.179_00905 1192034.CAP_7082 2.8e-44 186.0 Myxococcales ykfA 3.4.17.13 ko:K01297 ko00000,ko01000,ko01002,ko01011 Bacteria 1MWIY@1224,2WJ3S@28221,2YV3I@29,42Q52@68525,COG1619@1,COG1619@2 NA|NA|NA V LD-carboxypeptidase MAG.T1.179_00906 266940.Krad_0471 1.7e-71 275.8 Actinobacteria upp GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.9 ko:K00761 ko00240,ko01100,map00240,map01100 R00966 RC00063 ko00000,ko00001,ko01000 Bacteria 2GPJE@201174,COG0035@1,COG0035@2 NA|NA|NA F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate MAG.T1.179_00907 2045.KR76_24730 5e-51 207.2 Propionibacteriales tadA 3.5.4.1,3.5.4.33,3.8.1.5,6.3.4.19 ko:K01485,ko:K01563,ko:K04075,ko:K11991 ko00240,ko00330,ko00361,ko00625,ko01100,ko01120,map00240,map00330,map00361,map00625,map01100,map01120 R00974,R01411,R02922,R05284,R05367,R05368,R05369,R05370,R07669,R07670,R09597,R10223 RC00074,RC00477,RC00514,RC00809,RC01317,RC01340,RC01341,RC02013,RC02633,RC02634 ko00000,ko00001,ko01000,ko03016 Bacteria 2IM3Z@201174,4DQP2@85009,COG0590@1,COG0590@2 NA|NA|NA FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) MAG.T1.179_00908 479433.Caci_8567 3.7e-140 505.0 Actinobacteria pntB 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 R00112 RC00001 ko00000,ko00001,ko01000 Bacteria 2GNKB@201174,COG1282@1,COG1282@2 NA|NA|NA C the transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane MAG.T1.179_00909 1120960.ATXG01000003_gene2102 3.4e-25 120.9 Microbacteriaceae pntAB 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 R00112 RC00001 ko00000,ko00001,ko01000 Bacteria 2IKR9@201174,4FPHA@85023,COG3288@1,COG3288@2 NA|NA|NA C 4TM region of pyridine nucleotide transhydrogenase, mitoch MAG.T1.179_00910 351607.Acel_2022 1.9e-103 382.9 Frankiales pntAA 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 R00112 RC00001 ko00000,ko00001,ko01000 Bacteria 2I2FZ@201174,4ERQN@85013,COG3288@1,COG3288@2 NA|NA|NA C PFAM alanine dehydrogenase PNT domain protein MAG.T1.179_00911 1449058.JQKT01000009_gene122 1.5e-75 290.0 Bacteria 5.5.1.24 ko:K09834 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00112 R07502,R07503,R10623,R10624 RC01911 ko00000,ko00001,ko00002,ko01000 Bacteria 2Z7HP@2,arCOG12964@1 NA|NA|NA S Tocopherol cyclase MAG.T1.179_00912 471852.Tcur_4029 6.1e-19 99.8 Streptosporangiales 2.7.1.193 ko:K02803 ko00520,ko02060,map00520,map02060 M00267 R05199 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7 Bacteria 2IQIB@201174,4EKNU@85012,COG1264@1,COG1264@2 NA|NA|NA G phosphotransferase system, EIIB MAG.T1.179_00913 44060.JODL01000022_gene5029 2.9e-33 148.3 Actinobacteria crr 2.7.1.193,2.7.1.199 ko:K02777,ko:K02802,ko:K20116,ko:K20117,ko:K20118 ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111 M00265,M00266,M00267,M00268,M00270,M00272,M00303,M00806,M00809 R02738,R02780,R04111,R04394,R05132,R05199,R08559 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.1,4.A.1.1.13,4.A.1.1.14,4.A.1.1.2,4.A.1.1.9 Bacteria 2GK6B@201174,COG2190@1,COG2190@2 NA|NA|NA G Pts system MAG.T1.179_00914 1292373.H640_07474 2.5e-16 91.3 Actinobacteria ptsH ko:K03488,ko:K11189 ko00000,ko02000,ko03000 4.A.2.1 Bacteria 2GQX6@201174,COG1925@1,COG1925@2 NA|NA|NA G phosphocarrier protein hpr MAG.T1.179_00915 570268.ANBB01000035_gene2253 2.3e-168 599.0 Streptosporangiales ptsI 2.7.3.9 ko:K08483 ko02060,map02060 ko00000,ko00001,ko01000,ko02000 8.A.7 Bacteria 2GIZZ@201174,4EGVU@85012,COG1080@1,COG1080@2 NA|NA|NA G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) MAG.T1.179_00916 1193181.BN10_880001 2.2e-213 748.4 Intrasporangiaceae pntA GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006740,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008746,GO:0008750,GO:0009117,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016652,GO:0019362,GO:0019637,GO:0031224,GO:0031226,GO:0034641,GO:0036094,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0046483,GO:0046496,GO:0046983,GO:0048037,GO:0050661,GO:0050662,GO:0051186,GO:0051287,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072524,GO:0097159,GO:1901265,GO:1901360,GO:1901363,GO:1901564 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 R00112 RC00001 ko00000,ko00001,ko01000 iEcE24377_1341.EcE24377A_1810 Bacteria 2I2FZ@201174,4FEB2@85021,COG3288@1,COG3288@2 NA|NA|NA C NAD(P) transhydrogenase subunit alpha MAG.T1.179_00917 1193181.BN10_880002 1.3e-207 729.2 Intrasporangiaceae pntB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006740,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008746,GO:0008750,GO:0009117,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016652,GO:0019362,GO:0019637,GO:0031224,GO:0031226,GO:0034641,GO:0036094,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050661,GO:0050662,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072524,GO:0097159,GO:1901265,GO:1901360,GO:1901363,GO:1901564 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 R00112 RC00001 ko00000,ko00001,ko01000 iSBO_1134.SBO_1534,iYL1228.KPN_01527 Bacteria 2GNKB@201174,4FECY@85021,COG1282@1,COG1282@2 NA|NA|NA C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane MAG.T1.179_00918 196162.Noca_4337 8.8e-114 416.8 Propionibacteriales purC GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6,6.3.4.13 ko:K01923,ko:K01945,ko:K03566 ko00230,ko01100,ko01110,ko01130,ko02026,map00230,map01100,map01110,map01130,map02026 M00048 R04144,R04591 RC00064,RC00090,RC00162,RC00166 ko00000,ko00001,ko00002,ko01000,ko03000 Bacteria 2GK3H@201174,4DP92@85009,COG0152@1,COG0152@2 NA|NA|NA F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL MAG.T1.179_00919 105425.BBPL01000013_gene1809 4e-198 697.6 Streptacidiphilus purB 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKBR@201174,2NGEH@228398,COG0015@1,COG0015@2 NA|NA|NA F Adenylosuccinate lyase C-terminus MAG.T1.179_00920 1048339.KB913029_gene1446 4.6e-153 547.7 Frankiales purD GO:0000166,GO:0003674,GO:0003824,GO:0004637,GO:0005488,GO:0005524,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.2.6,6.3.3.1,6.3.4.13,6.3.5.3 ko:K01945,ko:K01952,ko:K11788,ko:K13713 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144,R04208,R04463,R04591 RC00010,RC00064,RC00090,RC00162,RC00166,RC01100,RC01160 ko00000,ko00001,ko00002,ko01000 iECNA114_1301.ECNA114_3417,iECSF_1327.ECSF_3859,iJN746.PP_4823,iPC815.YPO3729,iSB619.SA_RS05245,iYO844.BSU06530 Bacteria 2I2F5@201174,4ERHW@85013,COG0151@1,COG0151@2 NA|NA|NA F Belongs to the GARS family MAG.T1.179_00921 935866.JAER01000008_gene934 2.6e-178 631.7 Propionibacteriales 2.6.1.55 ko:K15372 ko00410,ko00430,ko01100,map00410,map00430,map01100 R00908,R01684 RC00006,RC00062 ko00000,ko00001,ko01000 Bacteria 2I2F3@201174,4DP1H@85009,COG0160@1,COG0160@2 NA|NA|NA E Aminotransferase class-III MAG.T1.179_00922 1379270.AUXF01000001_gene2197 3.7e-119 434.9 Gemmatimonadetes namA GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 1.14.13.40,1.6.99.1 ko:K00354,ko:K09461 ko00627,ko01120,map00627,map01120 R00282,R03998,R03999 RC00001,RC00244 ko00000,ko00001,ko01000 Bacteria 1ZTAW@142182,COG1902@1,COG1902@2 NA|NA|NA C NADH:flavin oxidoreductase / NADH oxidase family MAG.T1.179_00923 1499680.CCFE01000011_gene564 5.5e-69 268.5 Firmicutes Bacteria 1V0SJ@1239,COG5434@1,COG5434@2 NA|NA|NA M Parallel beta-helix repeats MAG.T1.179_00924 1081644.IMCC13023_01920 2.3e-192 678.3 Microbacteriaceae purA GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 Bacteria 2GMP4@201174,4FKSZ@85023,COG0104@1,COG0104@2 NA|NA|NA F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP MAG.T1.179_00925 446462.Amir_6917 2.9e-129 468.4 Pseudonocardiales fbaA GO:0003674,GO:0003824,GO:0004332,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016830,GO:0016832,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030312,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035375,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 iZ_1308.Z4263 Bacteria 2GM5P@201174,4DZK9@85010,COG0191@1,COG0191@2 NA|NA|NA G fructose-bisphosphate aldolase, class II, yeast E. coli subtype MAG.T1.179_00926 1121928.AUHE01000001_gene1507 1.1e-75 290.8 Gordoniaceae glcD2 GO:0000166,GO:0003674,GO:0003824,GO:0004457,GO:0004458,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006089,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016053,GO:0016491,GO:0016614,GO:0016898,GO:0019249,GO:0019516,GO:0019752,GO:0022900,GO:0022904,GO:0030447,GO:0032787,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046394,GO:0048037,GO:0050660,GO:0050662,GO:0051990,GO:0055114,GO:0071704,GO:0071949,GO:0072330,GO:0097159,GO:0099615,GO:1901265,GO:1901363,GO:1901576,GO:1901615,GO:1901617 1.1.2.4 ko:K00102 ko00620,map00620 R00197 RC00044 ko00000,ko00001,ko01000 Bacteria 2GKI9@201174,4GB5H@85026,COG0277@1,COG0277@2 NA|NA|NA C FAD linked oxidases, C-terminal domain MAG.T1.179_00927 436229.JOEH01000009_gene4397 7.6e-81 307.4 Streptacidiphilus glpQ 3.1.4.46 ko:K01126 ko00564,map00564 R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 Bacteria 2GMMS@201174,2NI2R@228398,COG0584@1,COG0584@2 NA|NA|NA C Glycerophosphoryl diester phosphodiesterase family MAG.T1.179_00928 172088.AUGA01000001_gene6522 8.4e-103 380.2 Bradyrhizobiaceae pheA GO:0003674,GO:0003824,GO:0004106,GO:0004664,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 2.5.1.54,4.2.1.51,5.4.99.5 ko:K03856,ko:K04518,ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022,M00024,M00025 R00691,R01373,R01715,R01826 RC00360,RC00435,RC03116 ko00000,ko00001,ko00002,ko01000 iECNA114_1301.ECNA114_2667 Bacteria 1MU60@1224,2TSUT@28211,3JS53@41294,COG0077@1,COG0077@2 NA|NA|NA E Prephenate dehydratase MAG.T1.179_00929 266940.Krad_0255 1.3e-41 177.2 Actinobacteria Bacteria 2GP42@201174,COG0561@1,COG0561@2 NA|NA|NA J hydrolase MAG.T1.179_00930 253839.SSNG_03609 1e-171 609.8 Actinobacteria serS GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 2GIWP@201174,COG0172@1,COG0172@2 NA|NA|NA J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) MAG.T1.179_00931 235985.BBPN01000034_gene854 4.6e-54 217.6 Streptacidiphilus bpa GO:0000502,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010604,GO:0016020,GO:0016043,GO:0019222,GO:0022607,GO:0022624,GO:0030162,GO:0030312,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0032268,GO:0032270,GO:0032991,GO:0042176,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0044877,GO:0045732,GO:0045862,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051259,GO:0051260,GO:0060255,GO:0061136,GO:0065003,GO:0065007,GO:0070628,GO:0071840,GO:0071944,GO:0080090,GO:1901800,GO:1902494,GO:1903050,GO:1903052,GO:1903362,GO:1903364,GO:1905368,GO:1905369 Bacteria 291ZT@1,2GR7R@201174,2NGN5@228398,2ZPJ4@2 NA|NA|NA S Protein of unknown function (DUF2587) MAG.T1.179_00932 1313172.YM304_23820 2.3e-39 168.7 Actinobacteria ko:K07117 ko00000 Bacteria 2GQAV@201174,COG2940@1,COG2940@2 NA|NA|NA K SET domain MAG.T1.179_00933 479431.Namu_4967 3.2e-83 315.5 Frankiales kch 3.6.1.22 ko:K03426,ko:K10716 ko00760,ko01100,ko04146,map00760,map01100,map04146 R00103,R03004,R11104 RC00002 ko00000,ko00001,ko01000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 Bacteria 2GKB8@201174,4ERFU@85013,COG1226@1,COG1226@2 NA|NA|NA P Ion channel MAG.T1.179_00935 479433.Caci_0163 1.1e-183 649.8 Actinobacteria atuC 2.1.3.15,6.4.1.2,6.4.1.3,6.4.1.4,6.4.1.5 ko:K01966,ko:K01969,ko:K13778,ko:K18472 ko00061,ko00280,ko00281,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00281,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212 M00036,M00082,M00373,M00741 R00742,R01859,R03494,R04138,R04386 RC00040,RC00097,RC00253,RC00367,RC00609,RC00942 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIRU@201174,COG4799@1,COG4799@2 NA|NA|NA I Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta MAG.T1.179_00936 1120948.KB903247_gene4611 1.3e-147 530.4 Pseudonocardiales 6.4.1.3,6.4.1.4 ko:K01965,ko:K01968 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00036,M00373,M00741 R01859,R04138 RC00097,RC00367,RC00609,RC00942 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIZP@201174,4DZTM@85010,COG4770@1,COG4770@2 NA|NA|NA I Acetyl propionyl-CoA carboxylase, alpha subunit MAG.T1.179_00937 106370.Francci3_4302 9.3e-21 106.3 Frankiales rsbV GO:0003674,GO:0005488,GO:0005515,GO:0042802 ko:K04749 ko00000,ko03021 Bacteria 2IHQG@201174,4ESTZ@85013,COG1366@1,COG1366@2 NA|NA|NA T Belongs to the anti-sigma-factor antagonist family MAG.T1.179_00938 47716.JOFH01000021_gene4179 4e-15 87.8 Actinobacteria 2.7.11.1 ko:K04757 ko00000,ko01000,ko01001,ko03021 Bacteria 2IHNR@201174,COG2172@1,COG2172@2 NA|NA|NA T anti-sigma regulatory factor MAG.T1.179_00939 2002.JOEQ01000018_gene7693 2.2e-268 931.8 Streptosporangiales hppA 3.6.1.1 ko:K15987 ko00190,map00190 ko00000,ko00001,ko01000 3.A.10.1 Bacteria 2GN8B@201174,4EGGE@85012,COG3808@1,COG3808@2 NA|NA|NA C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force MAG.T1.179_00940 1123320.KB889585_gene1745 8.6e-90 337.8 Actinobacteria rsmC ko:K00612 ko00000,ko01000 Bacteria 2GJPP@201174,COG2890@1,COG2890@2 NA|NA|NA J methyltransferase MAG.T1.179_00941 1123322.KB904713_gene5176 1.8e-285 988.8 Actinobacteria topA GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009892,GO:0010605,GO:0016020,GO:0016853,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0040007,GO:0043086,GO:0043167,GO:0043169,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060700,GO:0060701,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0140097 5.99.1.2 ko:K03168 ko00000,ko01000,ko03032,ko03400 Bacteria 2GJU7@201174,COG0550@1,COG0550@2,COG1754@1,COG1754@2 NA|NA|NA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone MAG.T1.179_00942 1101188.KI912155_gene1902 8.3e-51 207.2 Micrococcaceae tmk GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 1W963@1268,2GNTI@201174,COG0125@1,COG0125@2 NA|NA|NA F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis MAG.T1.179_00943 479435.Kfla_0588 9.8e-100 370.5 Propionibacteriales holB GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 2GJ8C@201174,4DNVR@85009,COG0470@1,COG0470@2 NA|NA|NA L DNA polymerase III MAG.T1.179_00945 266940.Krad_0491 5.4e-127 461.5 Actinobacteria slpD Bacteria 2GJYS@201174,COG0596@1,COG0596@2 NA|NA|NA NU Alpha beta hydrolase MAG.T1.179_00946 1380393.JHVP01000002_gene1670 1.5e-115 422.5 Frankiales rfbA GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0005996,GO:0006006,GO:0006139,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008879,GO:0009058,GO:0009059,GO:0009117,GO:0009141,GO:0009147,GO:0009200,GO:0009211,GO:0009219,GO:0009225,GO:0009226,GO:0009262,GO:0009394,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019299,GO:0019300,GO:0019305,GO:0019318,GO:0019319,GO:0019438,GO:0019637,GO:0019692,GO:0030312,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0045226,GO:0046075,GO:0046364,GO:0046379,GO:0046383,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv0334 Bacteria 2GP20@201174,4ETV6@85013,COG1209@1,COG1209@2 NA|NA|NA M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis MAG.T1.179_00947 43354.JOIJ01000013_gene689 1.3e-142 512.7 Pseudonocardiales rfbB 4.2.1.46,4.2.1.76 ko:K01710,ko:K12450 ko00520,ko00521,ko00523,ko00525,ko01055,ko01130,map00520,map00521,map00523,map00525,map01055,map01130 M00793 R00293,R06513 RC00402 ko00000,ko00001,ko00002,ko01000 Bacteria 2GNDU@201174,4E023@85010,COG1088@1,COG1088@2 NA|NA|NA M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily MAG.T1.179_00948 1463858.JOHR01000009_gene3366 2.5e-97 362.1 Actinobacteria rmlD GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008831,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019305,GO:0019438,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901576 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 Bacteria 2GNY8@201174,COG1091@1,COG1091@2 NA|NA|NA M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose MAG.T1.179_00949 1121272.KB903283_gene5123 2.3e-36 158.3 Actinobacteria Bacteria 2IIQY@201174,COG1917@1,COG1917@2 NA|NA|NA S Cupin 2, conserved barrel domain protein MAG.T1.179_00950 446471.Xcel_2560 8.2e-76 290.0 Promicromonosporaceae rmlC GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008830,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016853,GO:0016854,GO:0016857,GO:0018130,GO:0019305,GO:0019438,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901576 5.1.3.13 ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R06514 RC01531 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv3465 Bacteria 2GMW4@201174,4F3ZC@85017,COG1898@1,COG1898@2 NA|NA|NA M dTDP-4-dehydrorhamnose 3,5-epimerase MAG.T1.179_00952 365528.KB891289_gene4618 1.6e-122 446.4 Frankiales gntK GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0009987,GO:0030312,GO:0044464,GO:0044764,GO:0046812,GO:0051704,GO:0071944 2.3.1.82,2.7.1.12 ko:K00663,ko:K00851,ko:K07028 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 R01737 RC00002,RC00017 ko00000,ko00001,ko01000,ko01504 Bacteria 2GM3U@201174,4EUNB@85013,COG0645@1,COG0645@2,COG2187@1,COG2187@2 NA|NA|NA S AAA domain MAG.T1.179_00953 1283287.KB822582_gene2945 2e-54 219.2 Actinobacteria Bacteria 2I7QR@201174,COG4803@1,COG4803@2 NA|NA|NA S Protein of unknown function (DUF1269) MAG.T1.179_00954 1146883.BLASA_3175 3.1e-46 191.8 Actinobacteria Bacteria 2GTXG@201174,COG2197@1,COG2197@2 NA|NA|NA K helix_turn_helix, Lux Regulon MAG.T1.179_00956 446471.Xcel_1962 5.1e-57 227.6 Actinobacteria Bacteria 28PII@1,2GTGX@201174,32WVR@2 NA|NA|NA S Protein of unknown function (DUF4255) MAG.T1.179_00957 446471.Xcel_1961 8.5e-37 161.4 Bacteria Bacteria 2EA5X@1,334AT@2 NA|NA|NA MAG.T1.179_00958 446471.Xcel_1960 0.0 1246.9 Actinobacteria ko:K06907 ko00000 Bacteria 2GMJA@201174,COG3497@1,COG3497@2 NA|NA|NA S tail sheath protein MAG.T1.179_00959 446471.Xcel_1959 9e-56 223.0 Actinobacteria Bacteria 2DB76@1,2GKK0@201174,2Z7JZ@2 NA|NA|NA S T4-like virus tail tube protein gp19 MAG.T1.179_00960 446471.Xcel_1958 5.3e-180 637.9 Actinobacteria ko:K06907 ko00000 Bacteria 2IG6A@201174,COG3497@1,COG3497@2 NA|NA|NA S Phage tail sheath protein subtilisin-like domain MAG.T1.179_00961 379066.GAU_3439 2e-36 159.1 Bacteria Bacteria 2DMQT@1,32T2H@2 NA|NA|NA S T4-like virus tail tube protein gp19 MAG.T1.179_00963 446471.Xcel_1955 2e-73 282.3 Actinobacteria Bacteria 2IAAU@201174,COG1652@1,COG1652@2 NA|NA|NA S PFAM Peptidoglycan-binding MAG.T1.179_00964 446471.Xcel_1954 7.5e-137 493.8 Bacteria ko:K06905 ko00000 Bacteria COG3500@1,COG3500@2 NA|NA|NA MAG.T1.179_00965 446471.Xcel_1953 2.2e-39 169.5 Actinobacteria Bacteria 2GP13@201174,COG3501@1,COG3501@2 NA|NA|NA S Rhs element Vgr protein MAG.T1.179_00967 446471.Xcel_1951 6.4e-45 186.8 Actinobacteria ko:K06903 ko00000 Bacteria 2IFJ6@201174,COG3628@1,COG3628@2 NA|NA|NA S GPW gp25 family protein MAG.T1.179_00968 446471.Xcel_1950 1.4e-217 762.7 Actinobacteria Bacteria 2GM5C@201174,COG3299@1,COG3299@2 NA|NA|NA S Baseplate J-like protein MAG.T1.179_00969 446471.Xcel_1949 5e-147 528.5 Actinobacteria Bacteria 2I52J@201174,COG3391@1,COG3391@2 NA|NA|NA S Phage tail protein (Tail_P2_I) MAG.T1.179_00970 446471.Xcel_1948 5.6e-65 256.1 Actinobacteria ko:K02040,ko:K20276,ko:K21449 ko02010,ko02020,ko02024,ko05152,map02010,map02020,map02024,map05152 M00222 ko00000,ko00001,ko00002,ko02000 1.B.40.2,3.A.1.7 Bacteria 2IRA0@201174,COG4223@1,COG4223@2 NA|NA|NA M COG3209 Rhs family protein MAG.T1.179_00971 446471.Xcel_1947 6.7e-116 424.9 Actinobacteria Bacteria 28Q0Z@1,2IAZ4@201174,2ZCJM@2 NA|NA|NA MAG.T1.179_00972 446471.Xcel_1946 1.3e-135 490.3 Actinobacteria Bacteria 2ERBG@1,2GPQE@201174,33IX4@2 NA|NA|NA MAG.T1.179_00975 446471.Xcel_1943 5.3e-101 375.6 Actinobacteria Bacteria 2I8CR@201174,COG0464@1,COG0464@2 NA|NA|NA O PFAM AAA ATPase central domain protein MAG.T1.179_00978 397278.JOJN01000001_gene2848 2.2e-81 309.7 Propionibacteriales Bacteria 2I9AH@201174,4DMZA@85009,COG1403@1,COG1403@2 NA|NA|NA V HNH nucleases MAG.T1.179_00979 58123.JOFJ01000012_gene5336 1.5e-31 144.1 Streptosporangiales Bacteria 2IBIC@201174,4EH95@85012,COG2199@1,COG3706@2 NA|NA|NA T diguanylate cyclase MAG.T1.179_00981 1380347.JNII01000006_gene1628 1.3e-72 281.2 Actinobacteria Bacteria 2GJAR@201174,COG2909@1,COG2909@2 NA|NA|NA K transcriptional regulator MAG.T1.179_00982 68570.DC74_256 1.6e-116 426.0 Actinobacteria ppk2 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005525,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006183,GO:0006464,GO:0006468,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009889,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019219,GO:0019220,GO:0019222,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0030808,GO:0031323,GO:0031326,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0036211,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044403,GO:0044419,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046777,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051704,GO:0055086,GO:0062012,GO:0065007,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0080090,GO:0090407,GO:0097159,GO:0097367,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.4.1 ko:K22468 ko00190,ko03018,map00190,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 2GKRN@201174,COG2326@1,COG2326@2 NA|NA|NA G polyphosphate kinase MAG.T1.179_00983 32049.SYNPCC7002_A1469 4.9e-38 164.5 Synechococcus GO:0005575,GO:0005576,GO:0005615,GO:0044421 Bacteria 1G6R4@1117,1H17A@1129,COG2335@1,COG2335@2 NA|NA|NA M Fasciclin domain protein MAG.T1.179_00984 1121272.KB903249_gene2575 5.3e-45 188.0 Micromonosporales mpg GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.2.2.21 ko:K03652 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 2GNW1@201174,4DD25@85008,COG2094@1,COG2094@2 NA|NA|NA L Belongs to the DNA glycosylase MPG family MAG.T1.179_00985 477641.MODMU_2240 2.1e-81 309.7 Frankiales Bacteria 2GN4Y@201174,4ETWR@85013,COG0628@1,COG0628@2 NA|NA|NA S AI-2E family transporter MAG.T1.179_00986 1449044.JMLE01000005_gene690 1.4e-15 89.4 Actinobacteria XK27_09090 ko:K09153 ko00000 Bacteria 2GQZ0@201174,COG2456@1,COG2456@2 NA|NA|NA S Uncharacterized conserved protein (DUF2304) MAG.T1.179_00987 40571.JOEA01000010_gene3037 3.6e-73 281.6 Pseudonocardiales ycbB ko:K00786 ko00000,ko01000 Bacteria 2I2J1@201174,4DXD3@85010,COG1216@1,COG1216@2 NA|NA|NA S Glycosyl transferase family 2 MAG.T1.179_00988 1283283.ATXA01000005_gene2041 8.4e-190 670.6 Frankiales Bacteria 2GK30@201174,4ES04@85013,COG3973@1,COG3973@2 NA|NA|NA L DNA helicase MAG.T1.179_00989 1110697.NCAST_20_05770 7.5e-59 233.8 Nocardiaceae Bacteria 2IJG5@201174,4FVR0@85025,COG5587@1,COG5587@2 NA|NA|NA S Conserved hypothetical protein (DUF2461) MAG.T1.179_00990 66429.JOFL01000013_gene2959 6.5e-74 283.5 Actinobacteria ppa GO:0000287,GO:0003674,GO:0003824,GO:0004427,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0071944 3.6.1.1 ko:K01507 ko00190,map00190 ko00000,ko00001,ko01000 iNJ661.Rv3628 Bacteria 2GM7F@201174,COG0221@1,COG0221@2 NA|NA|NA C Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions MAG.T1.179_00991 1906.SFRA_18710 8.7e-63 248.1 Actinobacteria dacB 3.4.16.4 ko:K07259 ko00550,map00550 ko00000,ko00001,ko01000,ko01002,ko01011 Bacteria 2GJPH@201174,COG2027@1,COG2027@2 NA|NA|NA M D-alanyl-D-alanine carboxypeptidase MAG.T1.179_00992 1210045.ALNP01000035_gene2435 1.5e-88 333.2 Actinobacteria Bacteria 2GJ8E@201174,COG5282@1,COG5282@2 NA|NA|NA S protein, coenzyme F420 biosynthesis associated MAG.T1.179_00993 269800.Tfu_2897 1e-67 263.8 Streptosporangiales tilS 2.4.2.8,6.3.4.19 ko:K00760,ko:K04075,ko:K15780 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 R00190,R01132,R01229,R02142,R08237,R08238,R08245,R09597 RC00063,RC00122,RC02633,RC02634 ko00000,ko00001,ko01000,ko03016 Bacteria 2GJR4@201174,4EHNI@85012,COG0037@1,COG0037@2 NA|NA|NA D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine MAG.T1.179_00994 1184607.AUCHE_03_01750 3.2e-74 284.6 Dermatophilaceae hpt 2.4.2.8,6.3.4.19 ko:K00760,ko:K04075,ko:K15780 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 R00190,R01132,R01229,R02142,R08237,R08238,R08245,R09597 RC00063,RC00122,RC02633,RC02634 ko00000,ko00001,ko01000,ko03016 Bacteria 2GMDZ@201174,4F64W@85018,COG0634@1,COG0634@2 NA|NA|NA F Phosphoribosyl transferase domain MAG.T1.179_00995 4572.TRIUR3_22235-P1 2.2e-09 69.7 Eukaryota Eukaryota 2D3XI@1,2ST4T@2759 NA|NA|NA MAG.T1.179_00996 1304865.JAGF01000001_gene3500 5.9e-110 404.1 Actinobacteria ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GMSI@201174,COG3559@1,COG3559@2 NA|NA|NA M Exporter of polyketide MAG.T1.179_00997 68194.JNXR01000009_gene5140 2.5e-13 82.8 Actinobacteria Bacteria 2DDE4@1,2I38G@201174,2ZHP5@2 NA|NA|NA MAG.T1.179_00998 446469.Sked_30030 1.9e-91 342.4 Actinobacteria Bacteria 2GJJC@201174,COG0474@1,COG0474@2 NA|NA|NA P ATPase P-type (Transporting), HAD superfamily, subfamily IC MAG.T1.179_00999 397278.JOJN01000009_gene3672 3.2e-43 181.0 Propionibacteriales Bacteria 2IKPX@201174,4DRBT@85009,COG4898@1,COG4898@2 NA|NA|NA S Uncharacterized protein conserved in bacteria (DUF2200) MAG.T1.179_01001 1136417.AZWE01000012_gene2545 1.7e-08 67.8 Micromonosporales pspC ko:K03973 ko00000,ko02048,ko03000 Bacteria 2GIVS@201174,4DAQE@85008,COG1983@1,COG1983@2 NA|NA|NA KT PspC domain MAG.T1.179_01002 469383.Cwoe_1650 7.6e-59 234.6 Rubrobacteria tcsS3 Bacteria 2GJ4J@201174,4CRNY@84995,COG1983@1,COG1983@2,COG4585@1,COG4585@2 NA|NA|NA T Histidine kinase-like ATPases MAG.T1.179_01003 479432.Sros_1229 5.6e-65 254.2 Streptosporangiales degU ko:K07684 ko02020,map02020 M00471 ko00000,ko00001,ko00002,ko02022 Bacteria 2GIVA@201174,4EHIU@85012,COG2197@1,COG2197@2 NA|NA|NA T helix_turn_helix, Lux Regulon MAG.T1.179_01004 1121272.KB903254_gene6728 1.1e-76 293.9 Micromonosporales fbpC 3.6.3.30 ko:K02010 ko02010,map02010 M00190 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10 Bacteria 2GJCM@201174,4DCIX@85008,COG3842@1,COG3842@2 NA|NA|NA P TOBE domain MAG.T1.179_01005 318424.EU78_14165 2.8e-115 422.5 Mycobacteriaceae sfuB ko:K02011 ko02010,map02010 M00190 ko00000,ko00001,ko00002,ko02000 3.A.1.10 Bacteria 2347P@1762,2GKPT@201174,COG1178@1,COG1178@2 NA|NA|NA P binding-protein-dependent transport systems inner membrane component MAG.T1.179_01006 1078020.KEK_20058 2e-109 402.5 Mycobacteriaceae ko:K02012 ko02010,map02010 M00190 ko00000,ko00001,ko00002,ko02000 3.A.1.10 Bacteria 236RG@1762,2HPZ8@201174,COG1840@1,COG1840@2 NA|NA|NA P Extracellular solute-binding protein MAG.T1.179_01007 263358.VAB18032_00585 2.7e-167 595.5 Micromonosporales yheS_2 ko:K06158,ko:K18230 ko02010,map02010 ko00000,ko00001,ko01504,ko02000,ko03012 3.A.1.120 Bacteria 2GK9S@201174,4DA8K@85008,COG0488@1,COG0488@2 NA|NA|NA S ATPases associated with a variety of cellular activities MAG.T1.179_01008 446462.Amir_6924 2.2e-98 365.9 Pseudonocardiales nagA 3.5.1.25 ko:K01443 ko00520,ko01130,map00520,map01130 R02059 RC00166,RC00300 ko00000,ko00001,ko01000 Bacteria 2GK1E@201174,4DX8Z@85010,COG1820@1,COG1820@2 NA|NA|NA G Belongs to the metallo-dependent hydrolases superfamily. NagA family MAG.T1.179_01009 1211815.CBYP010000046_gene881 9.3e-20 102.8 Actinobacteria ko:K04752 ko00000 Bacteria 2H6FT@201174,COG0347@1,COG0347@2 NA|NA|NA E Belongs to the P(II) protein family MAG.T1.179_01010 1081644.IMCC13023_00390 6.8e-104 384.0 Microbacteriaceae ko:K07086 ko00000 Bacteria 2I8DP@201174,4FRC1@85023,COG3329@1,COG3329@2 NA|NA|NA S Na+-dependent bicarbonate transporter superfamily MAG.T1.179_01011 1240349.ANGC01000004_gene1728 3.6e-108 398.3 Nocardiaceae alx ko:K05794 ko00000 Bacteria 2GIWU@201174,4FUZ0@85025,COG0861@1,COG0861@2 NA|NA|NA P Integral membrane protein TerC family MAG.T1.179_01012 1397693.KK211187_gene1704 9.2e-202 709.9 Bacillales incertae sedis cdr2 Bacteria 1TPWW@1239,3WENZ@539002,4HA11@91061,COG0446@1,COG0446@2,COG0607@1,COG0607@2 NA|NA|NA P Belongs to the sulfur carrier protein TusA family MAG.T1.179_01013 861299.J421_2256 1.3e-84 319.7 Gemmatimonadetes arsM 2.1.1.137 ko:K07755 ko00000,ko01000 Bacteria 1ZSM8@142182,COG0500@1,COG2226@2 NA|NA|NA Q Hypothetical methyltransferase MAG.T1.179_01014 446465.Bfae_31180 5.1e-28 130.6 Dermabacteraceae ko:K03892 ko00000,ko03000 Bacteria 2IQDH@201174,4FD6A@85020,COG0640@1,COG0640@2 NA|NA|NA K helix_turn_helix, Arsenical Resistance Operon Repressor MAG.T1.179_01015 446471.Xcel_3344 2.1e-53 216.1 Promicromonosporaceae 1.20.4.1 ko:K03741,ko:K03892 ko00000,ko01000,ko03000 Bacteria 2IHR3@201174,4F4G0@85017,COG0394@1,COG0394@2,COG0640@1,COG0640@2 NA|NA|NA T Low molecular weight phosphatase family MAG.T1.179_01016 526225.Gobs_1145 4.7e-48 197.6 Frankiales MA20_23315 Bacteria 2IIUB@201174,4ESS1@85013,COG1765@1,COG1765@2 NA|NA|NA O PFAM OsmC family protein MAG.T1.179_01017 1463909.KL585957_gene2958 0.0 1080.5 Actinobacteria bgl2 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 GH3 Bacteria 2GJ5H@201174,COG1472@1,COG1472@2 NA|NA|NA G hydrolase, family 3 MAG.T1.179_01018 590998.Celf_0701 1.2e-16 92.8 Bacteria cbpA 2.4.1.333 ko:K21298 ko00000,ko01000 GH94 Bacteria COG3459@1,COG3459@2 NA|NA|NA G carbohydrate binding MAG.T1.179_01019 443218.AS9A_2146 1.5e-50 205.7 Actinobacteria Bacteria 2CAJE@1,2IMDF@201174,33XCP@2 NA|NA|NA MAG.T1.179_01020 1121017.AUFG01000012_gene1807 6.4e-206 723.8 Intrasporangiaceae malS GO:0003674,GO:0003824,GO:0004470,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006090,GO:0006108,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016614,GO:0016615,GO:0019752,GO:0032787,GO:0043436,GO:0043648,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071704 1.1.1.38 ko:K00027 ko00620,ko01200,ko02020,map00620,map01200,map02020 R00214 RC00105 ko00000,ko00001,ko01000 Bacteria 2GJAJ@201174,4FG5T@85021,COG0281@1,COG0281@2 NA|NA|NA C Malic enzyme, NAD binding domain MAG.T1.179_01021 593907.Celgi_1060 3.7e-170 605.5 Cellulomonadaceae ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 2H37M@201174,4F1Y9@85016,COG3127@1,COG3127@2 NA|NA|NA Q MacB-like periplasmic core domain MAG.T1.179_01022 1454010.JEOE01000003_gene259 9e-107 393.3 Actinobacteria ko:K02003 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GJN6@201174,COG1136@1,COG1136@2 NA|NA|NA V ABC transporter MAG.T1.179_01023 590998.Celf_2529 3.8e-92 344.7 Cellulomonadaceae tcsR2 Bacteria 2GJ46@201174,4F1QA@85016,COG2197@1,COG2197@2 NA|NA|NA T PFAM response regulator receiver MAG.T1.179_01024 590998.Celf_2528 2.7e-108 399.1 Cellulomonadaceae Bacteria 2GJEG@201174,4F1NE@85016,COG4585@1,COG4585@2 NA|NA|NA T PFAM histidine kinase dimerisation and phosphoacceptor region MAG.T1.179_01025 196162.Noca_4470 4.6e-59 234.2 Propionibacteriales hycG Bacteria 2IDTD@201174,4DUTR@85009,COG3260@1,COG3260@2 NA|NA|NA C NADH ubiquinone oxidoreductase, 20 Kd subunit MAG.T1.179_01026 196162.Noca_4469 4.4e-190 671.4 Propionibacteriales hyfB Bacteria 2HAC7@201174,4DSYG@85009,COG0651@1,COG0651@2 NA|NA|NA CP Proton-conducting membrane transporter MAG.T1.179_01027 1001240.GY21_03905 1.5e-95 356.3 Microbacteriaceae hycD Bacteria 2GJFM@201174,4FPM3@85023,COG0650@1,COG0650@2 NA|NA|NA C NADH dehydrogenase MAG.T1.179_01028 1001240.GY21_03900 8.6e-45 187.2 Microbacteriaceae hyfE GO:0008150,GO:0040007 ko:K12140 ko00000,ko01000 Bacteria 2HQ3P@201174,4FQSR@85023,COG4237@1,COG4237@2 NA|NA|NA C Hydrogenase 4 membrane MAG.T1.179_01029 196162.Noca_4466 2.4e-137 495.7 Propionibacteriales hyfF ko:K12141 ko00000,ko01000 Bacteria 2HAC7@201174,4DTN6@85009,COG0651@1,COG0651@2 NA|NA|NA CP Proton-conducting membrane transporter MAG.T1.179_01030 1001240.GY21_03890 7.9e-163 580.5 Microbacteriaceae hycE ko:K14089 ko00000 Bacteria 2GYM5@201174,4FSFF@85023,COG3261@1,COG3261@2,COG3262@1,COG3262@2 NA|NA|NA C Respiratory-chain NADH dehydrogenase, 49 Kd subunit MAG.T1.179_01031 1298863.AUEP01000017_gene4144 8.8e-32 142.9 Propionibacteriales arsR9 ko:K03892 ko00000,ko03000 Bacteria 2IKK2@201174,4DRX6@85009,COG0640@1,COG0640@2 NA|NA|NA K helix_turn_helix, Arsenical Resistance Operon Repressor MAG.T1.179_01032 1298863.AUEP01000017_gene4145 1.3e-147 530.0 Propionibacteriales sulP GO:0003333,GO:0003674,GO:0005215,GO:0005310,GO:0005326,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0008272,GO:0008509,GO:0008514,GO:0015075,GO:0015103,GO:0015116,GO:0015138,GO:0015141,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015238,GO:0015318,GO:0015556,GO:0015698,GO:0015711,GO:0015740,GO:0015741,GO:0015744,GO:0015800,GO:0015807,GO:0015810,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070778,GO:0071422,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0098656,GO:0098660,GO:0098661,GO:1901682,GO:1902358,GO:1902475,GO:1903825,GO:1905039 ko:K03321 ko00000,ko02000 2.A.53.3 iSbBS512_1146.SbBS512_E1370 Bacteria 2GJCB@201174,4DNAM@85009,COG0659@1,COG0659@2 NA|NA|NA P Sulfate permease family MAG.T1.179_01033 1121372.AULK01000001_gene1922 3e-78 298.5 Microbacteriaceae Bacteria 2GJUE@201174,4FPKA@85023,COG2267@1,COG2267@2 NA|NA|NA I Alpha/beta hydrolase family MAG.T1.179_01036 1385519.N801_06575 7.2e-173 613.6 Intrasporangiaceae Bacteria 2GJE2@201174,4FHMX@85021,COG3103@1,COG4991@2 NA|NA|NA T Peptidoglycan-binding protein MAG.T1.179_01038 1304865.JAGF01000001_gene2616 3.3e-87 327.8 Actinobacteria Bacteria 2GKX0@201174,COG0262@1,COG0262@2 NA|NA|NA H bifunctional deaminase-reductase domain protein MAG.T1.179_01039 324925.Ppha_0345 1.3e-15 89.7 Bacteria Bacteria COG2020@1,COG2020@2 NA|NA|NA O methyltransferase activity MAG.T1.179_01040 710421.Mycch_2937 2.3e-115 422.9 Bacteria ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria COG3559@1,COG3559@2 NA|NA|NA M Exporter of polyketide antibiotics MAG.T1.179_01041 710421.Mycch_2936 1.3e-102 379.8 Mycobacteriaceae ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 23350@1762,2GKEH@201174,COG1131@1,COG1131@2 NA|NA|NA V ABC transporter MAG.T1.179_01042 58123.JOFJ01000012_gene5413 4.3e-111 408.7 Streptosporangiales ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GMSI@201174,4EPCM@85012,COG3559@1,COG3559@2 NA|NA|NA M Exporter of polyketide MAG.T1.179_01043 58123.JOFJ01000012_gene5412 1.4e-101 376.3 Streptosporangiales ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GKEH@201174,4ENNZ@85012,COG1131@1,COG1131@2 NA|NA|NA V AAA domain, putative AbiEii toxin, Type IV TA system MAG.T1.179_01045 1121926.AXWO01000005_gene411 1.7e-20 105.5 Actinobacteria ko:K03892 ko00000,ko03000 Bacteria 2IRF0@201174,COG0640@1,COG0640@2 NA|NA|NA K helix_turn_helix, Arsenical Resistance Operon Repressor MAG.T1.179_01046 1121017.AUFG01000022_gene2176 5.5e-95 354.4 Intrasporangiaceae fieF Bacteria 2GJ8Q@201174,4FE8E@85021,COG0053@1,COG0053@2 NA|NA|NA P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family MAG.T1.179_01048 1214101.BN159_1336 6.9e-07 61.2 Actinobacteria Bacteria 2GTTI@201174,COG3976@1,COG3976@2 NA|NA|NA S FMN-binding domain protein MAG.T1.179_01050 58123.JOFJ01000012_gene5428 2.4e-41 176.0 Streptosporangiales apbE 2.7.1.180 ko:K03734 ko00000,ko01000 Bacteria 2GN6F@201174,4EPRS@85012,COG1477@1,COG1477@2 NA|NA|NA H ApbE family MAG.T1.179_01052 1283299.AUKG01000001_gene3534 1e-59 237.7 Rubrobacteria Bacteria 2GKWX@201174,4CRXT@84995,COG4097@1,COG4097@2 NA|NA|NA P FAD-binding domain MAG.T1.179_01054 1246995.AFR_11420 1.4e-36 159.8 Bacteria Bacteria 2E1Q9@1,32X0K@2 NA|NA|NA MAG.T1.179_01056 436229.JOEH01000017_gene6907 1.3e-67 262.7 Streptacidiphilus 2.3.1.128 ko:K01163,ko:K03790 ko00000,ko01000,ko03009 Bacteria 2H4AD@201174,2NKG7@228398,COG1670@1,COG1670@2 NA|NA|NA J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins MAG.T1.179_01059 1386089.N865_11320 6.4e-100 371.3 Intrasporangiaceae Bacteria 2GN56@201174,4FFV2@85021,COG1835@1,COG1835@2 NA|NA|NA I Acyltransferase family MAG.T1.179_01060 33898.JRHJ01000011_gene4893 2e-204 719.5 Actinobacteria gabT 2.6.1.19,2.6.1.22 ko:K00823,ko:K07250 ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120 M00027 R00908,R01648,R04188 RC00006,RC00062,RC00160 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 2GKVH@201174,COG0160@1,COG0160@2,COG2334@1,COG2334@2 NA|NA|NA E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family MAG.T1.179_01061 1032480.MLP_27620 7e-40 170.2 Propionibacteriales Bacteria 2AWFS@1,2IMS0@201174,31NC1@2,4DVM9@85009 NA|NA|NA MAG.T1.179_01062 1120950.KB892707_gene4971 4.7e-101 374.4 Propionibacteriales lgt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008961,GO:0009058,GO:0009059,GO:0009249,GO:0009898,GO:0009987,GO:0010467,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0051604,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:0140096,GO:1901564,GO:1901566,GO:1901576 2.1.1.199 ko:K03438,ko:K13292 ko00000,ko01000,ko03009 Bacteria 2GKSS@201174,4DP3T@85009,COG0682@1,COG0682@2 NA|NA|NA M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins MAG.T1.179_01063 1504319.GM45_1285 2.9e-39 169.1 unclassified Actinobacteria (class) pknE_1 Bacteria 2GKH8@201174,3UWV7@52018,COG1651@1,COG1651@2 NA|NA|NA O Thioredoxin MAG.T1.179_01064 35754.JNYJ01000014_gene4756 1.1e-51 209.9 Micromonosporales Bacteria 2GMVK@201174,4DD9S@85008,COG4243@1,COG4243@2 NA|NA|NA S VKc MAG.T1.179_01065 469371.Tbis_1452 2.3e-81 308.9 Pseudonocardiales trpA GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 Bacteria 2GN6T@201174,4E01I@85010,COG0159@1,COG0159@2 NA|NA|NA E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate MAG.T1.179_01066 1306174.JODP01000013_gene7463 2.6e-172 611.7 Actinobacteria trpB GO:0000162,GO:0003674,GO:0003824,GO:0004834,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 Bacteria 2GM7Z@201174,COG0133@1,COG0133@2 NA|NA|NA E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine MAG.T1.179_01067 1157635.KB892057_gene5130 3.6e-101 374.8 Actinobacteria trpC GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004425,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046391,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.48 ko:K01609 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508 RC00944 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIVV@201174,COG0134@1,COG0134@2 NA|NA|NA E Belongs to the TrpC family MAG.T1.179_01068 1463858.JOHR01000007_gene676 5.7e-15 87.4 Actinobacteria Bacteria 2E37T@1,2GQH5@201174,32Y7G@2 NA|NA|NA S Protein of unknown function (DUF2752) MAG.T1.179_01069 298653.Franean1_1613 1.4e-89 337.0 Frankiales Bacteria 2I53J@201174,4EU80@85013,COG0642@1,COG2205@2 NA|NA|NA T PhoQ Sensor MAG.T1.179_01070 1463825.JNXC01000005_gene2492 3e-82 311.6 Pseudonocardiales Bacteria 2GJE6@201174,4DZNW@85010,COG0745@1,COG0745@2 NA|NA|NA T Transcriptional regulatory protein, C terminal MAG.T1.179_01072 1157637.KB892090_gene6561 1.6e-184 652.5 Actinobacteria trpE 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKJT@201174,COG0147@1,COG0147@2 NA|NA|NA EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia MAG.T1.179_01073 1236902.ANAS01000018_gene3245 7.2e-31 140.2 Streptosporangiales hisI GO:0008150,GO:0040007 3.5.4.19,3.6.1.31 ko:K01496,ko:K11755 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035,R04037 RC00002,RC01055 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1606 Bacteria 2IKKU@201174,4EJM8@85012,COG0139@1,COG0139@2 NA|NA|NA E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP MAG.T1.179_01074 1449347.JQLN01000007_gene1639 8.5e-105 386.7 Kitasatospora hisF GO:0000107,GO:0003674,GO:0003824,GO:0008150,GO:0016740,GO:0016757,GO:0016763,GO:0040007 4.1.3.27 ko:K01657,ko:K02500 ko00340,ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00340,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023,M00026 R00985,R00986,R04558 RC00010,RC01190,RC01943,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIRP@201174,2M09X@2063,COG0107@1,COG0107@2 NA|NA|NA E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit MAG.T1.179_01075 1120948.KB903243_gene2486 3.6e-14 84.3 Pseudonocardiales Bacteria 2E35Q@1,2GS2Q@201174,32Y5M@2,4E724@85010 NA|NA|NA S Short C-terminal domain MAG.T1.179_01076 227882.SAV_1926 7.5e-39 166.8 Actinobacteria Bacteria 2IIN1@201174,COG4803@1,COG4803@2 NA|NA|NA S membrane protein of uknown function UCP014873 MAG.T1.179_01077 1385517.N800_12005 1.4e-64 254.2 Xanthomonadales aarF ko:K03688 ko00000 Bacteria 1MU1Z@1224,1RNQ9@1236,1X410@135614,COG0661@1,COG0661@2 NA|NA|NA S Ubiquinone biosynthesis protein MAG.T1.179_01078 324602.Caur_0429 7.9e-07 61.2 Chloroflexia yvlD ko:K08972 ko00000 Bacteria 2G7E6@200795,375XQ@32061,COG1950@1,COG1950@2 NA|NA|NA S PFAM membrane protein of MAG.T1.179_01079 1380347.JNII01000008_gene4164 4.1e-26 124.4 Frankiales 4.2.99.21 ko:K04782 ko01053,ko01110,ko01130,map01053,map01110,map01130 R06602 RC01549,RC02148 ko00000,ko00001,ko01000 Bacteria 2IIB2@201174,4ETK2@85013,COG0251@1,COG0251@2 NA|NA|NA J Endoribonuclease L-PSP MAG.T1.179_01080 561175.KB894098_gene5366 3.6e-105 387.9 Streptosporangiales hisA GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16,5.3.1.24 ko:K01814,ko:K01817 ko00340,ko00400,ko01100,ko01110,ko01130,ko01230,map00340,map00400,map01100,map01110,map01130,map01230 M00023,M00026 R03509,R04640 RC00945 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ4V@201174,4EGBG@85012,COG0106@1,COG0106@2 NA|NA|NA E Histidine biosynthesis protein MAG.T1.179_01081 1120960.ATXG01000009_gene10 2.1e-82 312.0 Microbacteriaceae hisH GO:0000105,GO:0000107,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIYS@201174,4FKZP@85023,COG0118@1,COG0118@2 NA|NA|NA E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR MAG.T1.179_01082 710111.FraQA3DRAFT_6511 1.4e-75 289.3 Frankiales hisB GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0004424,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042578,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23,2.6.1.9,3.1.3.15,4.2.1.19 ko:K00013,ko:K00817,ko:K01089,ko:K01693 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R01158,R01163,R03012,R03013,R03243,R03457 RC00006,RC00017,RC00099,RC00242,RC00463,RC00888,RC00932 ko00000,ko00001,ko00002,ko01000,ko01007 iECO111_1330.ECO111_2746,iECS88_1305.ECS88_2121,iJN746.PP_0289,iLJ478.TM1039,iSB619.SA_RS14130,iUMNK88_1353.UMNK88_2570 Bacteria 2GKMD@201174,4ESDH@85013,COG0131@1,COG0131@2 NA|NA|NA E Imidazoleglycerol-phosphate dehydratase MAG.T1.179_01083 408672.NBCG_04907 1.5e-121 443.0 Propionibacteriales hisC GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 2GJ9W@201174,4DPP5@85009,COG0079@1,COG0079@2 NA|NA|NA E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily MAG.T1.179_01084 1996.JOFO01000003_gene6293 2.3e-163 582.0 Streptosporangiales hisD GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23,1.1.1.308 ko:K00013,ko:K15509 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKKA@201174,4EHY2@85012,COG0141@1,COG0141@2 NA|NA|NA E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine MAG.T1.179_01085 1048339.KB913029_gene4558 9e-39 167.2 Frankiales lonD 3.4.21.53 ko:K01338,ko:K07157 ko04112,map04112 ko00000,ko00001,ko01000,ko01002 Bacteria 2GNWA@201174,4ET5K@85013,COG2802@1,COG2802@2 NA|NA|NA S Peptidase S16, lon domain protein MAG.T1.179_01086 1123320.KB889675_gene3833 2.1e-48 198.7 Actinobacteria ybaK GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0043906,GO:0043907,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 ko:K03976 ko00000,ko01000,ko03016 Bacteria 2IHS8@201174,COG2606@1,COG2606@2 NA|NA|NA S Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily MAG.T1.179_01087 351607.Acel_1054 0.0 1629.8 Frankiales dnaE 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 2GJ1P@201174,4ERD2@85013,COG0587@1,COG0587@2 NA|NA|NA L DNA polymerase III alpha subunit MAG.T1.179_01088 483219.LILAB_07875 3.5e-177 628.2 Myxococcales fhs GO:0000096,GO:0000097,GO:0000105,GO:0003674,GO:0003824,GO:0004329,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006144,GO:0006520,GO:0006547,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009108,GO:0009110,GO:0009112,GO:0009113,GO:0009256,GO:0009257,GO:0009396,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0016874,GO:0016879,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0042398,GO:0042440,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0052803,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.5.1.5,3.5.4.9,6.3.4.3 ko:K00288,ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00141,M00377 R00943,R01220,R01655 RC00026,RC00111,RC00202,RC00578 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1MUR8@1224,2WJF1@28221,2YZGJ@29,42MKE@68525,COG2759@1,COG2759@2 NA|NA|NA F Belongs to the formate--tetrahydrofolate ligase family MAG.T1.179_01089 471852.Tcur_0033 4e-103 381.3 Streptosporangiales ydbC 1.1.1.65 ko:K05275 ko00750,ko01100,ko01120,map00750,map01100,map01120 R01708 RC00116 ko00000,ko00001,ko01000 Bacteria 2GJ6R@201174,4EICB@85012,COG0667@1,COG0667@2 NA|NA|NA C Aldo/keto reductase family MAG.T1.179_01090 1121017.AUFG01000014_gene2014 1.4e-114 419.5 Intrasporangiaceae rluD GO:0000027,GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022607,GO:0022613,GO:0022618,GO:0031118,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360 5.4.99.23,5.4.99.28,5.4.99.29 ko:K06177,ko:K06180 ko00000,ko01000,ko03009,ko03016 iE2348C_1286.E2348C_2868,iECED1_1282.ECED1_3035,iECSF_1327.ECSF_2432 Bacteria 2GIY1@201174,4FFFW@85021,COG0564@1,COG0564@2 NA|NA|NA J Responsible for synthesis of pseudouridine from uracil MAG.T1.179_01091 298654.FraEuI1c_2385 1.5e-36 159.5 Frankiales lspA 3.4.23.36 ko:K03101 ko03060,map03060 ko00000,ko00001,ko01000,ko01002 Bacteria 2GKRX@201174,4ET0T@85013,COG0597@1,COG0597@2 NA|NA|NA MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins MAG.T1.179_01092 1116232.AHBF01000005_gene1545 2.5e-35 155.2 Actinobacteria dksA ko:K06204 ko02026,map02026 ko00000,ko00001,ko03000,ko03009,ko03021 Bacteria 2GJBE@201174,COG1734@1,COG1734@2 NA|NA|NA T Transcriptional regulator, TraR DksA family MAG.T1.179_01093 471857.Svir_27290 1.9e-12 78.6 Pseudonocardiales MA20_25230 ko:K09131 ko00000 Bacteria 2GQSC@201174,4E6KR@85010,COG1872@1,COG1872@2 NA|NA|NA EGP Belongs to the UPF0235 family MAG.T1.179_01094 1123322.KB904652_gene570 0.0 1504.6 Actinobacteria ileS GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iG2583_1286.G2583_0027,iPC815.YPO0475 Bacteria 2GK9M@201174,COG0060@1,COG0060@2 NA|NA|NA J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) MAG.T1.179_01095 935866.JAER01000007_gene424 1.7e-41 177.2 Propionibacteriales Bacteria 2AUNZ@1,2GP4I@201174,31KBW@2,4DRN6@85009 NA|NA|NA S Protein of unknown function (DUF2786) MAG.T1.179_01096 1452536.JARE01000050_gene1860 1.7e-09 69.3 Microbacteriaceae wag31 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008360,GO:0009273,GO:0009987,GO:0016020,GO:0022603,GO:0022604,GO:0030312,GO:0031647,GO:0040007,GO:0042546,GO:0044085,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0050821,GO:0051128,GO:0060187,GO:0065007,GO:0065008,GO:0071554,GO:0071840,GO:0071944 Bacteria 2GMSC@201174,4FNCA@85023,COG3599@1,COG3599@2 NA|NA|NA D DivIVA protein MAG.T1.179_01097 1184609.KILIM_034_00410 1e-15 89.4 Dermatophilaceae yggT GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K02221 ko00000,ko02044 Bacteria 2GQI1@201174,4F798@85018,COG0762@1,COG0762@2 NA|NA|NA S YGGT family MAG.T1.179_01098 1122611.KB903978_gene3351 7.6e-41 173.7 Streptosporangiales sepF GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0007049,GO:0008150,GO:0009987,GO:0016043,GO:0022402,GO:0022607,GO:0032506,GO:0042802,GO:0044085,GO:0051301,GO:0071840,GO:0090529 ko:K09772 ko00000,ko03036 Bacteria 2GNVH@201174,4EIJC@85012,COG1799@1,COG1799@2 NA|NA|NA D Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA MAG.T1.179_01099 58123.JOFJ01000001_gene3034 4.1e-66 258.1 Streptosporangiales yggS GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 ko:K06997 ko00000 Bacteria 2GMRJ@201174,4EGGM@85012,COG0325@1,COG0325@2 NA|NA|NA S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis MAG.T1.179_01100 882083.SacmaDRAFT_3694 1.9e-48 199.5 Pseudonocardiales yfiH GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016679,GO:0016682,GO:0030312,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0046983,GO:0055114,GO:0071944 ko:K05810 ko00000,ko01000 Bacteria 2GN1M@201174,4DZFD@85010,COG1496@1,COG1496@2 NA|NA|NA S Belongs to the multicopper oxidase YfiH RL5 family MAG.T1.179_01101 68223.JNZY01000002_gene5187 1e-154 553.1 Actinobacteria ftsZ GO:0000166,GO:0000287,GO:0000910,GO:0000921,GO:0000935,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006996,GO:0007010,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022402,GO:0022607,GO:0030428,GO:0031106,GO:0032153,GO:0032155,GO:0032185,GO:0032506,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0045787,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051258,GO:0051301,GO:0051726,GO:0065003,GO:0065007,GO:0070925,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:1901265,GO:1901363 ko:K03531 ko04112,map04112 ko00000,ko00001,ko02048,ko03036,ko04812 Bacteria 2GJWC@201174,COG0206@1,COG0206@2 NA|NA|NA D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity MAG.T1.179_01102 446462.Amir_5761 3.2e-24 119.0 Pseudonocardiales ftsQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0071944 6.3.2.4 ko:K01921,ko:K03589,ko:K06438 ko00473,ko00550,ko01100,ko01502,ko04112,map00473,map00550,map01100,map01502,map04112 R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011,ko03036 Bacteria 2H4A4@201174,4E3DB@85010,COG1589@1,COG1589@2 NA|NA|NA D Cell division protein FtsQ MAG.T1.179_01103 1048339.KB913029_gene4575 2.1e-138 499.2 Frankiales murC GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 Bacteria 2I2E7@201174,4ERUC@85013,COG0773@1,COG0773@2 NA|NA|NA M Belongs to the MurCDEF family MAG.T1.179_01104 1288083.AUKR01000001_gene1241 6.3e-119 434.1 Actinobacteria murG 2.4.1.227,6.3.2.8 ko:K01924,ko:K02563 ko00471,ko00550,ko01100,ko01502,ko04112,map00471,map00550,map01100,map01502,map04112 R03193,R05032,R05662 RC00005,RC00049,RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 GT28 iLJ478.TM0232 Bacteria 2GJEM@201174,COG0707@1,COG0707@2 NA|NA|NA M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) MAG.T1.179_01105 1120950.KB892707_gene4889 2.9e-91 342.4 Propionibacteriales ftsW GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008360,GO:0009987,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032153,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051179,GO:0051234,GO:0051301,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:1901264,GO:1901505 2.4.1.227 ko:K02563,ko:K03588 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011,ko02000,ko03036 2.A.103.1 GT28 Bacteria 2GKXP@201174,4DNHR@85009,COG0772@1,COG0772@2 NA|NA|NA D Belongs to the SEDS family MAG.T1.179_01106 1048339.KB913029_gene4578 1.3e-148 533.1 Frankiales murD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 iNJ661.Rv2155c Bacteria 2GJZA@201174,4ERI0@85013,COG0771@1,COG0771@2 NA|NA|NA M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) MAG.T1.179_01107 1504319.GM45_1105 4.5e-117 427.9 unclassified Actinobacteria (class) mraY GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 iAF987.Gmet_0409,iEC042_1314.EC042_0088,iECABU_c1320.ECABU_c00920,iECED1_1282.ECED1_0088,iECH74115_1262.ECH74115_0095,iECSP_1301.ECSP_0090,iECs_1301.ECs0091,iG2583_1286.G2583_0091,iSDY_1059.SDY_0117,iZ_1308.Z0097,ic_1306.c0105 Bacteria 2GNEH@201174,3UWA7@52018,COG0472@1,COG0472@2 NA|NA|NA M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan MAG.T1.179_01108 146922.JOFU01000006_gene2820 3.6e-135 488.4 Actinobacteria murF 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 Bacteria 2GK0Y@201174,COG0770@1,COG0770@2 NA|NA|NA M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein MAG.T1.179_01109 1120950.KB892707_gene4885 5.2e-143 514.6 Propionibacteriales murE GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.10,6.3.2.13 ko:K01928,ko:K15792 ko00300,ko00550,map00300,map00550 R02788,R04617 RC00064,RC00090,RC00141 ko00000,ko00001,ko01000,ko01011 iNJ661.Rv2158c Bacteria 2GIS2@201174,4DN64@85009,COG0769@1,COG0769@2 NA|NA|NA M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan MAG.T1.179_01110 1504319.GM45_1090 1.4e-139 503.4 unclassified Actinobacteria (class) ftsI GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008144,GO:0008150,GO:0008658,GO:0008955,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0031224,GO:0031226,GO:0031406,GO:0032153,GO:0033218,GO:0033293,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:1901363,GO:1901681 3.4.16.4 ko:K03587,ko:K08384,ko:K08724,ko:K12552,ko:K12556 ko00550,ko01100,ko01501,map00550,map01100,map01501 ko00000,ko00001,ko01000,ko01011,ko03036 iSSON_1240.SSON_0092 Bacteria 2GKHH@201174,3UWG5@52018,COG0768@1,COG0768@2 NA|NA|NA M Penicillin-binding Protein dimerisation domain MAG.T1.179_01111 479435.Kfla_2879 3.4e-14 85.9 Propionibacteriales ftsL ko:K05589,ko:K12065 ko00000,ko02044,ko03036 3.A.7.11.1 Bacteria 2GW5Q@201174,4DS2Z@85009,COG2919@1,COG2919@2 NA|NA|NA D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic MAG.T1.179_01112 65497.JODV01000002_gene4329 2.2e-107 395.6 Pseudonocardiales rsmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 ko:K03438 ko00000,ko01000,ko03009 Bacteria 2GJGK@201174,4DZ61@85010,COG0275@1,COG0275@2 NA|NA|NA M Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA MAG.T1.179_01114 1504319.GM45_1075 2.9e-43 181.4 unclassified Actinobacteria (class) mraZ GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0040007,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 ko:K03925 ko00000 Bacteria 2IHUB@201174,3UWSJ@52018,COG2001@1,COG2001@2 NA|NA|NA K MraZ protein, putative antitoxin-like MAG.T1.179_01115 994479.GL877879_gene5041 1.3e-67 262.7 Pseudonocardiales Bacteria 2GN4R@201174,4DZ99@85010,COG2030@1,COG2030@2 NA|NA|NA I MaoC like domain MAG.T1.179_01116 67352.JODS01000001_gene448 2.1e-105 389.0 Actinobacteria yeaC ko:K03924 ko00000,ko01000 Bacteria 2GK07@201174,COG0714@1,COG0714@2 NA|NA|NA S associated with various cellular activities MAG.T1.179_01117 1463936.JOJI01000017_gene7472 3.6e-44 186.0 Actinobacteria Bacteria 2GIWE@201174,COG1721@1,COG1721@2 NA|NA|NA J protein some members contain a von Willebrand factor type A vWA domain MAG.T1.179_01119 367299.JOEE01000002_gene2391 1.1e-08 65.1 Intrasporangiaceae pdhA 1.2.4.1 ko:K00161 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2GK3W@201174,4FF0X@85021,COG1071@1,COG1071@2 NA|NA|NA C Pyruvate dehydrogenase E1 MAG.T1.179_01120 469371.Tbis_3331 6.3e-126 457.2 Pseudonocardiales pdhB GO:0003674,GO:0005488,GO:0005515,GO:0140030,GO:0140032 1.2.4.1 ko:K00162,ko:K21417 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS05355,iYO844.BSU14590 Bacteria 2GKFE@201174,4E0CR@85010,COG0022@1,COG0022@2 NA|NA|NA C Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase component beta subunit MAG.T1.179_01121 1211815.CBYP010000051_gene667 2.2e-97 362.8 Frankiales pdhC 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2GM0D@201174,4ERC0@85013,COG0508@1,COG0508@2 NA|NA|NA C of components of various dehydrogenase complexes MAG.T1.179_01122 1246448.ANAZ01000004_gene4671 9e-107 395.2 Streptosporangiales sbcC GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0006139,GO:0006259,GO:0006260,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360,GO:1901576 ko:K03546 ko00000,ko03400 Bacteria 2GKYR@201174,4EG84@85012,COG0419@1,COG0419@2 NA|NA|NA L AAA domain MAG.T1.179_01123 446465.Bfae_27310 2.2e-85 322.8 Dermabacteraceae sbcD ko:K03547 ko00000,ko03400 Bacteria 2GK9R@201174,4FBAD@85020,COG0420@1,COG0420@2 NA|NA|NA L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity MAG.T1.179_01124 263358.VAB18032_25150 3.1e-100 372.1 Micromonosporales Bacteria 2GK0T@201174,4DCHZ@85008,COG3214@1,COG3214@2 NA|NA|NA S Winged helix DNA-binding domain MAG.T1.179_01125 349521.HCH_05422 2.6e-25 122.1 Oceanospirillales FolA Bacteria 1RH02@1224,1S2UN@1236,1XKZU@135619,COG0262@1,COG0262@2 NA|NA|NA H RibD C-terminal domain MAG.T1.179_01126 2074.JNYD01000017_gene4333 6.5e-74 284.3 Pseudonocardiales ku GO:0000726,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006303,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050790,GO:0050896,GO:0051340,GO:0051351,GO:0051716,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 ko:K10979 ko03450,map03450 ko00000,ko00001,ko03400 Bacteria 2GJMU@201174,4E10U@85010,COG1273@1,COG1273@2 NA|NA|NA L With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD MAG.T1.179_01127 1172188.KB911823_gene665 1.7e-84 320.1 Intrasporangiaceae Bacteria 2I37Q@201174,4FFGA@85021,COG0025@1,COG0025@2 NA|NA|NA P Sodium/hydrogen exchanger family MAG.T1.179_01128 110319.CF8_0638 1.6e-57 229.2 Actinobacteria lemA ko:K03744 ko00000 Bacteria 2GPS4@201174,COG1704@1,COG1704@2 NA|NA|NA J LemA family MAG.T1.179_01129 1240349.ANGC01000055_gene4012 2.7e-146 525.8 Nocardiaceae yciQ GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 2GNW7@201174,4G3G3@85025,COG4907@1,COG4907@2 NA|NA|NA S Predicted membrane protein (DUF2207) MAG.T1.179_01130 196162.Noca_4423 4.8e-49 202.2 Propionibacteriales 2.7.13.3 ko:K02484,ko:K07653,ko:K07654 ko02020,map02020 M00460,M00461 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 2I3U8@201174,4DU9B@85009,COG5002@1,COG5002@2 NA|NA|NA T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain MAG.T1.179_01131 66377.JOBH01000010_gene6019 6.8e-66 257.3 Actinobacteria Bacteria 2GMVN@201174,COG0745@1,COG0745@2 NA|NA|NA T response regulator MAG.T1.179_01132 66429.JOFL01000001_gene4522 7e-50 204.9 Actinobacteria nuoF2 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2GNN9@201174,COG1894@1,COG1894@2 NA|NA|NA C NADH ubiquinone oxidoreductase NADH-binding (51 kD) subunit MAG.T1.179_01133 1206731.BAGB01000163_gene7753 3.8e-19 101.7 Nocardiaceae Bacteria 2GQH2@201174,4G1BH@85025,COG4097@1,COG4097@2 NA|NA|NA P Ferric reductase like transmembrane component MAG.T1.179_01134 235985.BBPN01000004_gene3114 1.3e-32 147.1 Streptacidiphilus apbE 2.7.1.180 ko:K03734 ko00000,ko01000 Bacteria 2H74Y@201174,2NF9E@228398,COG1477@1,COG1477@2 NA|NA|NA H ApbE family MAG.T1.179_01137 1120948.KB903217_gene1344 1.4e-19 103.6 Actinobacteria Bacteria 2IPMP@201174,COG3064@1,COG3064@2,COG4733@1,COG4733@2 NA|NA|NA M calcium- and calmodulin-responsive adenylate cyclase activity MAG.T1.179_01138 1283283.ATXA01000008_gene3123 2.8e-45 188.7 Frankiales Bacteria 2CA7I@1,2IFD8@201174,2ZTHS@2,4EV1F@85013 NA|NA|NA MAG.T1.179_01139 1380370.JIBA01000012_gene3816 6e-67 261.2 Intrasporangiaceae ko:K04088,ko:K14393 M00742 ko00000,ko00002,ko01000,ko02000 2.A.21.7 Bacteria 2IE4A@201174,4FIM4@85021,COG0330@1,COG0330@2 NA|NA|NA O SPFH domain / Band 7 family MAG.T1.179_01140 2002.JOEQ01000025_gene232 8e-07 60.1 Streptosporangiales ko:K06975 ko00000 Bacteria 2GQNP@201174,4EKDK@85012,COG2388@1,COG2388@2 NA|NA|NA S GCN5-related N-acetyl-transferase MAG.T1.179_01142 1386089.N865_21145 9.9e-68 263.8 Actinobacteria GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016874,GO:0016879,GO:0016881,GO:0018169,GO:0018410,GO:0019538,GO:0031668,GO:0033554,GO:0036211,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0070739,GO:0071496,GO:0071704,GO:0140096,GO:1901564 ko:K03281,ko:K03455,ko:K03499,ko:K05571,ko:K05844,ko:K07402,ko:K11105 ko00000,ko01000,ko02000,ko03009 2.A.36.6,2.A.37,2.A.38.1,2.A.38.4,2.A.49,2.A.63.1,2.A.63.2 Bacteria 2I2I2@201174,COG0569@1,COG0569@2 NA|NA|NA P Ion transport protein MAG.T1.179_01143 1380390.JIAT01000011_gene2324 4.2e-22 112.5 Rubrobacteria Bacteria 2GK0H@201174,4CTG0@84995,COG0628@1,COG0628@2 NA|NA|NA S AI-2E family transporter MAG.T1.179_01144 1298863.AUEP01000012_gene3662 2.7e-36 158.7 Propionibacteriales ko:K21429 ko00000,ko01002 Bacteria 2GKWI@201174,4DUPV@85009,COG4894@1,COG4894@2 NA|NA|NA S LURP-one-related MAG.T1.179_01145 1386089.N865_21420 2.2e-29 135.2 Intrasporangiaceae Bacteria 2AY0M@1,2I859@201174,32Z2S@2,4FH02@85021 NA|NA|NA S Phospholipase_D-nuclease N-terminal MAG.T1.179_01146 1229780.BN381_800004 1.5e-06 60.5 Actinobacteria ko:K11748 ko00000,ko02000 2.A.37.1.2 Bacteria 2DDQ5@1,2HDNV@201174,2ZIVU@2 NA|NA|NA MAG.T1.179_01147 1122182.KB903814_gene3437 1.3e-29 137.1 Micromonosporales kipA Bacteria 2GITH@201174,4DBQR@85008,COG1984@1,COG1984@2 NA|NA|NA E Allophanate hydrolase subunit 2 MAG.T1.179_01148 1151126.AQYI01000006_gene2850 2.8e-34 152.1 Microbacteriaceae ybgK Bacteria 2GITH@201174,4FMAJ@85023,COG1984@1,COG1984@2,COG2049@1,COG2049@2 NA|NA|NA E Allophanate hydrolase subunit 2 MAG.T1.179_01149 44060.JODL01000024_gene339 2.2e-41 176.0 Actinobacteria lamB ko:K07160 ko00000 Bacteria 2GJA1@201174,COG1540@1,COG1540@2 NA|NA|NA S Belongs to the UPF0271 (lamB) family MAG.T1.179_01150 216594.MMAR_1906 6.7e-19 99.8 Mycobacteriaceae Bacteria 23AN3@1762,2IQKN@201174,COG5552@1,COG5552@2 NA|NA|NA S Uncharacterized conserved protein (DUF2277) MAG.T1.179_01151 1043205.AFYF01000087_gene1224 1.9e-91 344.0 Intrasporangiaceae 2.7.8.12 ko:K09809 ko00000,ko01000 Bacteria 2GM0T@201174,4FISM@85021,COG1887@1,COG1887@2 NA|NA|NA M CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase MAG.T1.179_01152 1121019.AUMN01000024_gene3593 5.4e-127 462.2 Actinobacteria Bacteria 2GJZ6@201174,COG1216@1,COG1216@2 NA|NA|NA M PFAM Glycosyl transferase family 2 MAG.T1.179_01154 33876.JNXY01000002_gene363 5e-51 209.5 Actinobacteria Bacteria 2IR52@201174,COG1525@1,COG1525@2 NA|NA|NA L Lamin Tail Domain MAG.T1.179_01155 1150399.AQYK01000002_gene2654 4.6e-205 721.5 Microbacteriaceae tagX 2.7.8.12 ko:K09809 ko00000,ko01000 Bacteria 2GM0T@201174,4FK9M@85023,COG0438@1,COG0438@2,COG1887@1,COG1887@2 NA|NA|NA M CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase MAG.T1.179_01156 1121385.AQXW01000004_gene3278 9.4e-15 86.3 Dermacoccaceae phhB 3.5.4.33,4.2.1.96 ko:K01724,ko:K11991 ko00790,map00790 R04734,R10223 RC00477,RC01208 ko00000,ko00001,ko01000,ko03016,ko04147 Bacteria 1ZW7J@145357,2IHZE@201174,COG2154@1,COG2154@2 NA|NA|NA H Pterin 4 alpha carbinolamine dehydratase MAG.T1.179_01158 1043493.BBLU01000021_gene657 3.1e-54 218.0 Actinobacteria ko:K06929 ko00000 Bacteria 2IJYY@201174,COG1832@1,COG1832@2 NA|NA|NA S PFAM CoA-binding domain protein MAG.T1.179_01159 1463856.JOHY01000043_gene7260 7.9e-184 650.2 Actinobacteria der GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 1.1.1.399,1.1.1.95 ko:K00058,ko:K03977 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko03009,ko04147 Bacteria 2GJ8J@201174,COG1160@1,COG1160@2 NA|NA|NA F GTPase that plays an essential role in the late steps of ribosome biogenesis MAG.T1.179_01160 1229203.KI301992_gene1081 1e-56 226.9 unclassified Actinobacteria (class) cmk GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 ko:K00945,ko:K03977 ko00240,ko01100,map00240,map01100 M00052 R00158,R00512,R01665 RC00002 ko00000,ko00001,ko00002,ko01000,ko03009 Bacteria 2H3SI@201174,3UWT7@52018,COG0283@1,COG0283@2 NA|NA|NA F Cytidylate kinase MAG.T1.179_01161 1210046.B277_08400 4.7e-82 311.6 Intrasporangiaceae tyrA 1.3.1.12,1.3.1.43 ko:K00210,ko:K00220,ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025,M00040 R00732,R01728 RC00125 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKB4@201174,4FF8J@85021,COG0287@1,COG0287@2 NA|NA|NA E Prephenate dehydrogenase MAG.T1.179_01162 1463881.KL591011_gene2890 7.2e-35 153.3 Actinobacteria aroH GO:0003674,GO:0003824,GO:0004106,GO:0006082,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016866,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044281,GO:0046417,GO:0071704 2.7.4.25,5.4.99.5 ko:K00945,ko:K06208 ko00240,ko00400,ko01100,ko01110,ko01130,ko01230,map00240,map00400,map01100,map01110,map01130,map01230 M00024,M00025,M00052 R00158,R00512,R01665,R01715 RC00002,RC03116 ko00000,ko00001,ko00002,ko01000 Bacteria 2IHWT@201174,COG4401@1,COG4401@2 NA|NA|NA E Chorismate mutase MAG.T1.179_01163 1184607.AUCHE_05_03990 2.2e-83 315.5 Dermatophilaceae rluB GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.19,5.4.99.22 ko:K06178,ko:K06183 ko00000,ko01000,ko03009 Bacteria 2GJ4N@201174,4F65G@85018,COG1187@1,COG1187@2 NA|NA|NA J RNA pseudouridylate synthase MAG.T1.179_01164 1122611.KB904029_gene5405 5.3e-54 217.6 Streptosporangiales scpB ko:K06024 ko00000,ko03036 Bacteria 2GISY@201174,4EG7D@85012,COG1386@1,COG1386@2 NA|NA|NA K Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves MAG.T1.179_01165 1283287.KB822585_gene2646 7.8e-80 303.9 Propionibacteriales scpA ko:K05896 ko00000,ko03036 Bacteria 2GN1U@201174,4DMYR@85009,COG1354@1,COG1354@2 NA|NA|NA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves MAG.T1.179_01166 351607.Acel_1240 1.7e-104 386.0 Frankiales soj GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009295,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044424,GO:0044464,GO:0071944 ko:K03496 ko00000,ko03036,ko04812 Bacteria 2GJX3@201174,4ERYA@85013,COG1192@1,COG1192@2 NA|NA|NA D PFAM Cobyrinic acid a,c-diamide synthase MAG.T1.179_01167 1120950.KB892767_gene5149 3.8e-104 384.8 Propionibacteriales xerD GO:0008150,GO:0040007 ko:K03733,ko:K04763 ko00000,ko03036 Bacteria 2GNDP@201174,4DNSC@85009,COG4974@1,COG4974@2 NA|NA|NA L tyrosine recombinase MAG.T1.179_01168 219305.MCAG_04961 5.5e-158 563.9 Micromonosporales ald 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 R00396 RC00008 ko00000,ko00001,ko01000 Bacteria 2GJ6G@201174,4DA3S@85008,COG0686@1,COG0686@2 NA|NA|NA C Belongs to the AlaDH PNT family MAG.T1.179_01169 1177594.MIC448_2500030 5.3e-40 171.0 Microbacteriaceae nudF 3.6.1.13 ko:K01515 ko00230,map00230 R01054 RC00002 ko00000,ko00001,ko01000 Bacteria 2GNW6@201174,4FNIB@85023,COG0494@1,COG0494@2 NA|NA|NA L NUDIX domain MAG.T1.179_01170 471852.Tcur_2836 1.1e-260 905.6 Streptosporangiales pyrG GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1276,iECO103_1326.ECO103_3323,iHN637.CLJU_RS01075,iNJ661.Rv1699,iPC815.YPO3377 Bacteria 2GJ13@201174,4EFKB@85012,COG0504@1,COG0504@2 NA|NA|NA F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates MAG.T1.179_01171 66875.JODY01000020_gene275 6.2e-132 478.0 Actinobacteria recN GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0030312,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:1901360 ko:K03631,ko:K13582 ko04112,map04112 ko00000,ko00001,ko03400 Bacteria 2GIVG@201174,COG0497@1,COG0497@2 NA|NA|NA L May be involved in recombinational repair of damaged DNA MAG.T1.179_01172 1048339.KB913029_gene4067 4.8e-96 357.8 Frankiales nadK GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0006082,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006793,GO:0006796,GO:0006797,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 R00104 RC00002,RC00078 ko00000,ko00001,ko01000 Bacteria 2GKM2@201174,4ERHI@85013,COG0061@1,COG0061@2 NA|NA|NA G Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP MAG.T1.179_01173 479433.Caci_5431 4.7e-87 327.8 Actinobacteria tlyA GO:0000154,GO:0001510,GO:0001897,GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019835,GO:0019836,GO:0022613,GO:0031167,GO:0031640,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035821,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044003,GO:0044004,GO:0044085,GO:0044179,GO:0044237,GO:0044238,GO:0044260,GO:0044364,GO:0044403,GO:0044419,GO:0044764,GO:0046483,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.226,2.1.1.227 ko:K06442 ko00000,ko01000,ko03009 Bacteria 2GJVT@201174,COG1189@1,COG1189@2 NA|NA|NA J Ribosomal RNA methyltransferase RrmJ FtsJ MAG.T1.179_01176 452652.KSE_57300 2.2e-79 302.8 Kitasatospora yutF GO:0000121,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009395,GO:0009987,GO:0016042,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0030145,GO:0042578,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0046434,GO:0046475,GO:0046486,GO:0046503,GO:0046872,GO:0046914,GO:0046983,GO:0050897,GO:0071704,GO:1901575 3.1.3.41 ko:K01101 ko00627,ko01120,map00627,map01120 R03024 RC00151 ko00000,ko00001,ko01000 Bacteria 2GK7V@201174,2M1NB@2063,COG0647@1,COG0647@2 NA|NA|NA G Haloacid dehalogenase-like hydrolase MAG.T1.179_01177 266940.Krad_3800 7.7e-22 110.5 Actinobacteria Bacteria 2GKX5@201174,COG0457@1,COG0457@2 NA|NA|NA A Belongs to the DEAD box helicase family MAG.T1.179_01178 1504319.GM45_1000 1.8e-201 708.8 unclassified Actinobacteria (class) crtI 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 ko:K10027 ko00906,ko01100,ko01110,map00906,map01100,map01110 R04787,R04798,R04800,R09691,R09692 RC01214,RC02088,RC02605 ko00000,ko00001,ko01000 Bacteria 2GJAV@201174,3UXB3@52018,COG1233@1,COG1233@2 NA|NA|NA Q Flavin containing amine oxidoreductase MAG.T1.179_01179 1121019.AUMN01000024_gene3573 1.3e-83 317.4 Micrococcaceae ko:K14337,ko:K14339 ko00000,ko01000,ko01003 Bacteria 1WCDZ@1268,2AMJ0@1,2I3ZG@201174,31CER@2 NA|NA|NA MAG.T1.179_01180 1155718.KB891896_gene2107 4.6e-13 81.3 Actinobacteria Bacteria 2IKZ0@201174,COG2732@1,COG2732@2 NA|NA|NA K Barstar (barnase inhibitor) MAG.T1.179_01181 29306.JOBE01000002_gene2854 2.8e-28 131.7 Actinobacteria 3.1.27.3 ko:K01167,ko:K15125 ko05133,map05133 ko00000,ko00001,ko00536,ko01000,ko03016,ko03019 Bacteria 2IHPV@201174,COG4290@1,COG4290@2 NA|NA|NA F Ribonuclease MAG.T1.179_01182 1504319.GM45_0995 1.4e-90 339.7 unclassified Actinobacteria (class) crtB GO:0003674,GO:0003824,GO:0004337,GO:0004659,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016108,GO:0016109,GO:0016114,GO:0016116,GO:0016117,GO:0016740,GO:0016765,GO:0016767,GO:0042440,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046148,GO:0071704,GO:1901576 2.5.1.21,2.5.1.32,2.5.1.96,2.5.1.99 ko:K00801,ko:K02291,ko:K10208 ko00100,ko00906,ko00909,ko01062,ko01100,ko01110,ko01130,map00100,map00906,map00909,map01062,map01100,map01110,map01130 M00097 R00702,R02065,R02872,R04218,R06223,R07270,R07652,R09793,R10177 RC00362,RC00796,RC01101,RC02839,RC02869 ko00000,ko00001,ko00002,ko01000,ko01006 Bacteria 2HFT6@201174,3UXMW@52018,COG1562@1,COG1562@2 NA|NA|NA I Squalene/phytoene synthase MAG.T1.179_01183 1246995.AFR_09710 1.2e-25 123.2 Micromonosporales Bacteria 2E9MI@1,2IMX9@201174,333U6@2,4DG5M@85008 NA|NA|NA S lycopene cyclase MAG.T1.179_01184 134676.ACPL_1706 2e-29 135.6 Micromonosporales crtY Bacteria 2CPEY@1,2I84R@201174,32SIY@2,4DFG6@85008 NA|NA|NA S lycopene cyclase domain MAG.T1.179_01186 397278.JOJN01000001_gene2592 1.5e-132 480.3 Propionibacteriales pknL 2.7.11.1 ko:K12132 ko00000,ko01000,ko01001 Bacteria 2GJ1J@201174,4DPC3@85009,COG0515@1,COG0515@2,COG2815@1,COG2815@2 NA|NA|NA KLT serine threonine protein kinase MAG.T1.179_01187 479433.Caci_6006 1.8e-68 266.2 Actinobacteria ydeD Bacteria 2I8X5@201174,COG0697@1,COG0697@2 NA|NA|NA EG of the drug metabolite transporter (DMT) superfamily MAG.T1.179_01188 1283283.ATXA01000003_gene1425 3.8e-113 414.8 Frankiales ltaA 4.1.2.48 ko:K01620 ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230 R00751,R06171 RC00312,RC00372 ko00000,ko00001,ko01000 Bacteria 2GMNV@201174,4ERZD@85013,COG2008@1,COG2008@2 NA|NA|NA E Beta-eliminating lyase MAG.T1.179_01190 471852.Tcur_2640 1.1e-179 636.3 Streptosporangiales aroH 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJBX@201174,4EGEY@85012,COG3200@1,COG3200@2 NA|NA|NA E Class-II DAHP synthetase family MAG.T1.179_01191 278957.ABEA03000041_gene2097 1.7e-168 599.0 Opitutae pfp 2.7.1.90 ko:K00895 ko00010,ko00030,ko00051,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map01100,map01110,map01120,map01130 R00764,R02073 RC00017 ko00000,ko00001,ko01000 Bacteria 3K75J@414999,46UQV@74201,COG0205@1,COG0205@2 NA|NA|NA H Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions MAG.T1.179_01192 1236902.ANAS01000015_gene578 9e-191 673.3 Streptosporangiales glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 Bacteria 2GM13@201174,4EFI5@85012,COG0554@1,COG0554@2 NA|NA|NA C Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate MAG.T1.179_01193 710696.Intca_1969 8.3e-86 323.6 Intrasporangiaceae plsC 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 2GJ6V@201174,4FEIG@85021,COG0204@1,COG0204@2 NA|NA|NA I 1-acyl-sn-glycerol-3-phosphate acyltransferase MAG.T1.179_01194 1048339.KB913029_gene4594 6.2e-60 237.7 Frankiales yvaK 3.1.1.1 ko:K03928 ko00000,ko01000 Bacteria 2GM1Y@201174,4ETTX@85013,COG1647@1,COG1647@2 NA|NA|NA S Serine aminopeptidase, S33 MAG.T1.179_01195 1896.JOAU01000001_gene4484 9e-12 77.4 Actinobacteria Bacteria 2EN8E@1,2GMI1@201174,33FW7@2 NA|NA|NA MAG.T1.179_01197 1122138.AQUZ01000033_gene3595 1.6e-33 149.1 Propionibacteriales Bacteria 2IFH4@201174,4DRBM@85009,COG2867@1,COG2867@2 NA|NA|NA I Polyketide cyclase / dehydrase and lipid transport MAG.T1.179_01198 1306174.JODP01000009_gene6550 2e-24 119.4 Actinobacteria Bacteria 2IBDE@201174,COG2197@1,COG2197@2 NA|NA|NA T Two component transcriptional regulator, luxr family MAG.T1.179_01199 471852.Tcur_2117 1.7e-54 220.3 Streptosporangiales Bacteria 2GN1J@201174,4EJA0@85012,COG5650@1,COG5650@2 NA|NA|NA S Glycosyltransferase family 87 MAG.T1.179_01200 561175.KB894094_gene1431 1.7e-133 482.6 Streptosporangiales pimB 2.4.1.346,3.2.1.8 ko:K01181,ko:K13668 R11703,R11704 ko00000,ko01000,ko01003 GT4 Bacteria 2GM6D@201174,4EHII@85012,COG0438@1,COG0438@2 NA|NA|NA M Glycosyl transferases group 1 MAG.T1.179_01201 1048339.KB913029_gene4617 8e-12 75.9 Actinobacteria Bacteria 2EGHN@1,2GSZ1@201174,33A9R@2 NA|NA|NA MAG.T1.179_01202 196162.Noca_3127 6.6e-21 106.3 Actinobacteria Bacteria 2ES7R@1,2IQ6C@201174,33JSG@2 NA|NA|NA MAG.T1.179_01203 1193181.BN10_360026 3.9e-166 591.7 Intrasporangiaceae cho GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006289,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009380,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016787,GO:0016788,GO:0030312,GO:0031668,GO:0032991,GO:0033554,GO:0033683,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1902494,GO:1905347,GO:1905348,GO:1990391 2.7.7.7 ko:K02342,ko:K03763,ko:K05984 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 2GMC0@201174,4FEF6@85021,COG0322@1,COG0322@2,COG2176@1,COG2176@2 NA|NA|NA L Contains 3'-5'exonuclease domain MAG.T1.179_01204 1504319.GM45_0755 3.2e-194 684.9 unclassified Actinobacteria (class) petD GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009512,GO:0009579,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0040007,GO:0044424,GO:0044425,GO:0044436,GO:0044459,GO:0044464,GO:0070069,GO:0071944 ko:K00412,ko:K02635,ko:K02637,ko:K03887,ko:K03891,ko:K15879 ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152,M00162 ko00000,ko00001,ko00002,ko00194,ko03029 Bacteria 2GJ1E@201174,3UWCW@52018,COG1290@1,COG1290@2 NA|NA|NA C Cytochrome b/b6/petB MAG.T1.179_01205 1504319.GM45_0760 6e-103 380.9 unclassified Actinobacteria (class) qcrA GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K03890,ko:K15878 ko00190,ko01100,map00190,map01100 M00151 ko00000,ko00001,ko00002 iAF987.Gmet_0538 Bacteria 2GIX6@201174,3UWCF@52018,COG0723@1,COG0723@2 NA|NA|NA C Rieske [2Fe-2S] domain MAG.T1.179_01206 1504319.GM45_0765 1.2e-71 276.6 unclassified Actinobacteria (class) qcrC GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K00406,ko:K03889 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00151,M00156 ko00000,ko00001,ko00002 3.D.4.3 Bacteria 2GKUB@201174,3UWHN@52018,COG2010@1,COG2010@2 NA|NA|NA C Cytochrome C oxidase, cbb3-type, subunit III MAG.T1.179_01207 1214101.BN159_6284 3.2e-70 271.6 Actinobacteria ctaE GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 1.9.3.1 ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.6 iJN678.ctaE Bacteria 2GKK8@201174,COG1845@1,COG1845@2 NA|NA|NA C cytochrome c oxidase, subunit III MAG.T1.179_01208 196162.Noca_3132 6.1e-46 190.3 Propionibacteriales GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 Bacteria 2II71@201174,4DQR3@85009,COG0784@1,COG0784@2 NA|NA|NA T cheY-homologous receiver domain MAG.T1.179_01209 469371.Tbis_1298 5.1e-92 344.7 Pseudonocardiales trpD 2.4.2.18,4.1.3.27 ko:K00766,ko:K13497 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R00985,R00986,R01073 RC00010,RC00440,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 Bacteria 2GM4G@201174,4DYFX@85010,COG0547@1,COG0547@2 NA|NA|NA E Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) MAG.T1.179_01211 351607.Acel_0958 2.8e-24 118.2 Frankiales ctaF GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 2D9MJ@1,2IFFM@201174,32TTI@2,4ETA5@85013 NA|NA|NA C Belongs to the cytochrome c oxidase bacterial subunit CtaF family MAG.T1.179_01212 446466.Cfla_2081 5.1e-240 837.0 Cellulomonadaceae ctaD GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 Bacteria 2GJHX@201174,4F1WI@85016,COG0843@1,COG0843@2 NA|NA|NA C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B MAG.T1.179_01213 1504319.GM45_0705 5.6e-70 271.2 unclassified Actinobacteria (class) ctaC GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0040007,GO:0042773,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044237,GO:0044238,GO:0044281,GO:0044403,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0051704,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 Bacteria 2GNXA@201174,3UWMS@52018,COG1622@1,COG1622@2 NA|NA|NA C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) MAG.T1.179_01214 1394178.AWOO02000084_gene1172 1e-90 340.5 Streptosporangiales 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 Bacteria 2GJ2B@201174,4EHSY@85012,COG1104@1,COG1104@2 NA|NA|NA E Beta-eliminating lyase MAG.T1.179_01215 1713.JOFV01000020_gene1360 9.1e-13 79.7 Cellulomonadaceae 2.8.1.7 ko:K04085,ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 Bacteria 2GSF4@201174,4F2Z8@85016,COG0425@1,COG0425@2 NA|NA|NA O Sulfurtransferase TusA MAG.T1.179_01216 367299.JOEE01000004_gene1430 9.1e-66 256.9 Intrasporangiaceae aat 2.3.2.6 ko:K00684 R03813,R11443,R11444 RC00055,RC00064 ko00000,ko01000 Bacteria 2IFT7@201174,4FFYP@85021,COG2360@1,COG2360@2 NA|NA|NA O Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine MAG.T1.179_01217 1123320.KB889675_gene3934 3.1e-128 464.9 Actinobacteria adoK GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004001,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005975,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019200,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032552,GO:0032553,GO:0032554,GO:0032555,GO:0032559,GO:0032560,GO:0032561,GO:0032567,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046390,GO:0046483,GO:0046835,GO:0046872,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.15,2.7.1.20 ko:K00852,ko:K00856 ko00030,ko00230,ko01100,map00030,map00230,map01100 R00185,R01051,R02750 RC00002,RC00017 ko00000,ko00001,ko01000 iAF987.Gmet_2683 Bacteria 2GKBG@201174,COG0524@1,COG0524@2 NA|NA|NA G Ribokinase MAG.T1.179_01218 1463855.JOHV01000002_gene2392 1e-49 202.6 Actinobacteria erpA GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009061,GO:0009987,GO:0010467,GO:0015980,GO:0016020,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055114,GO:0071704,GO:0071840,GO:0071944,GO:1901564 ko:K13628,ko:K15724 ko00000,ko03016 Bacteria 2IHR0@201174,COG0316@1,COG0316@2 NA|NA|NA S Belongs to the HesB IscA family MAG.T1.179_01219 1048339.KB913029_gene4641 9.2e-85 320.9 Frankiales glxK GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 2.7.1.165 ko:K00865 ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130 R08572 RC00002,RC00428 ko00000,ko00001,ko01000 Bacteria 2GKHX@201174,4ERQR@85013,COG1929@1,COG1929@2 NA|NA|NA G Belongs to the glycerate kinase type-1 family MAG.T1.179_01220 512565.AMIS_14080 5.9e-174 617.1 Micromonosporales nadA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 Bacteria 2GM59@201174,4D97S@85008,COG0379@1,COG0379@2 NA|NA|NA H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate MAG.T1.179_01221 561175.KB894094_gene1456 8.1e-65 253.4 Streptosporangiales Bacteria 2GP15@201174,31PZA@2,4EIMY@85012,arCOG04740@1 NA|NA|NA MAG.T1.179_01222 749414.SBI_05309 1.2e-102 379.8 Actinobacteria htpX ko:K03799 M00743 ko00000,ko00002,ko01000,ko01002 Bacteria 2GMJF@201174,COG0501@1,COG0501@2 NA|NA|NA O Belongs to the peptidase M48B family MAG.T1.179_01223 1032480.MLP_42080 1.5e-67 263.1 Propionibacteriales pspA ko:K03969 ko00000 Bacteria 2GP0K@201174,4DPJS@85009,COG1842@1,COG1842@2 NA|NA|NA KT PspA/IM30 family MAG.T1.179_01224 1303692.SFUL_1738 6.9e-32 144.1 Actinobacteria GO:0008150,GO:0009605,GO:0009607,GO:0020012,GO:0030682,GO:0042783,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0075136 Bacteria 2AN86@1,2HWWU@201174,31D67@2 NA|NA|NA S membrane MAG.T1.179_01225 469371.Tbis_1278 5.1e-139 500.7 Pseudonocardiales GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0004033,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006887,GO:0006955,GO:0008076,GO:0008150,GO:0008152,GO:0009117,GO:0009898,GO:0009987,GO:0010959,GO:0012505,GO:0012506,GO:0015459,GO:0016020,GO:0016021,GO:0016192,GO:0016247,GO:0016491,GO:0016614,GO:0016616,GO:0019362,GO:0019637,GO:0019897,GO:0019898,GO:0030141,GO:0030424,GO:0030659,GO:0030667,GO:0031090,GO:0031224,GO:0031226,GO:0031234,GO:0031410,GO:0031982,GO:0032879,GO:0032880,GO:0032940,GO:0032991,GO:0033267,GO:0034641,GO:0034702,GO:0034703,GO:0034705,GO:0034762,GO:0034765,GO:0035579,GO:0036230,GO:0042119,GO:0042581,GO:0042995,GO:0043005,GO:0043226,GO:0043227,GO:0043229,GO:0043266,GO:0043269,GO:0043299,GO:0043312,GO:0044224,GO:0044237,GO:0044238,GO:0044281,GO:0044304,GO:0044422,GO:0044424,GO:0044425,GO:0044433,GO:0044444,GO:0044446,GO:0044459,GO:0044463,GO:0044464,GO:0045055,GO:0045321,GO:0046483,GO:0046496,GO:0046903,GO:0050789,GO:0050794,GO:0050896,GO:0051049,GO:0051179,GO:0051186,GO:0051234,GO:0055086,GO:0055114,GO:0060341,GO:0065007,GO:0065009,GO:0070820,GO:0070821,GO:0070995,GO:0071704,GO:0071944,GO:0072524,GO:0097458,GO:0097708,GO:0098552,GO:0098562,GO:0098588,GO:0098772,GO:0098796,GO:0098797,GO:0098805,GO:0099106,GO:0099503,GO:0120025,GO:0120038,GO:1901360,GO:1901379,GO:1901564,GO:1902495,GO:1903827,GO:1904062,GO:1990031,GO:1990351,GO:2000008 Bacteria 2GMT5@201174,4DX8D@85010,COG0667@1,COG0667@2 NA|NA|NA C aldo keto reductase MAG.T1.179_01226 981369.JQMJ01000004_gene2066 7.6e-16 89.4 Streptacidiphilus Bacteria 2EFWK@1,2IQXQ@201174,2NK0Q@228398,339NW@2 NA|NA|NA MAG.T1.179_01227 1449355.JQNR01000003_gene515 1.1e-26 127.1 Actinobacteria Bacteria 2E883@1,2I8J4@201174,332M6@2 NA|NA|NA MAG.T1.179_01228 1120950.KB892707_gene4769 3.8e-74 285.4 Propionibacteriales ecfT GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015238,GO:0015711,GO:0015893,GO:0016020,GO:0022857,GO:0032217,GO:0032218,GO:0034220,GO:0035461,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051180,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0090482,GO:0098656 ko:K02008,ko:K16783,ko:K16785 ko02010,map02010 M00245,M00246,M00581,M00582 ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23,3.A.1.25,3.A.1.25.1,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 Bacteria 2GKHK@201174,4DPHW@85009,COG0619@1,COG0619@2 NA|NA|NA P Cobalt transport protein MAG.T1.179_01229 479435.Kfla_2709 2.6e-188 665.2 Propionibacteriales ko:K16786,ko:K16787 ko02010,map02010 M00582 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 Bacteria 2I2Y2@201174,4DP2H@85009,COG3845@1,COG3845@2 NA|NA|NA S AAA domain, putative AbiEii toxin, Type IV TA system MAG.T1.179_01230 1463864.JOGO01000009_gene499 3.8e-66 258.5 Actinobacteria ko:K02006,ko:K16784,ko:K16786,ko:K16787,ko:K16927 ko02010,map02010 M00245,M00246,M00581,M00582 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.18,3.A.1.22,3.A.1.23,3.A.1.25,3.A.1.25.1,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 Bacteria 2GMK1@201174,COG1122@1,COG1122@2 NA|NA|NA P ECF transporter, substrate-specific component MAG.T1.179_01231 1078020.KEK_15608 1.2e-98 367.1 Mycobacteriaceae cobU 2.7.1.156,2.7.7.62 ko:K02231 ko00860,ko01100,map00860,map01100 M00122 R05221,R05222,R06558 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 Bacteria 23984@1762,2GM8Q@201174,COG1235@1,COG1235@2,COG2087@1,COG2087@2 NA|NA|NA H cobinamide kinase MAG.T1.179_01232 446462.Amir_1358 8.7e-100 370.5 Pseudonocardiales cobT 2.4.2.21 ko:K00768 ko00860,ko01100,map00860,map01100 M00122 R04148 RC00033,RC00063 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv2207 Bacteria 2GJ16@201174,4DX78@85010,COG2038@1,COG2038@2 NA|NA|NA H Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) MAG.T1.179_01233 469371.Tbis_1275 3.1e-35 155.6 Pseudonocardiales cobS GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008818,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.8.26 ko:K02233 ko00860,ko01100,map00860,map01100 M00122 R05223,R11174 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKM4@201174,4E2M6@85010,COG0368@1,COG0368@2 NA|NA|NA H Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate MAG.T1.179_01234 2074.JNYD01000003_gene3655 1.1e-107 396.7 Pseudonocardiales gcvT GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ47@201174,4DXZ6@85010,COG0404@1,COG0404@2 NA|NA|NA E The glycine cleavage system catalyzes the degradation of glycine MAG.T1.179_01235 266940.Krad_3276 1e-127 463.8 Actinobacteria pepA GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 Bacteria 2GJRB@201174,COG0260@1,COG0260@2 NA|NA|NA E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides MAG.T1.179_01236 65497.JODV01000003_gene4511 8.7e-198 696.4 Pseudonocardiales lpdA 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GIXY@201174,4DZEU@85010,COG1249@1,COG1249@2 NA|NA|NA C TIGRFAM Dihydrolipoamide dehydrogenase MAG.T1.179_01238 1348663.KCH_26840 8.9e-38 162.9 Kitasatospora zur GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010043,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0046872,GO:0046914,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 ko:K02076,ko:K03711,ko:K09823 ko02024,map02024 ko00000,ko00001,ko03000 Bacteria 2IKS3@201174,2M2R1@2063,COG0735@1,COG0735@2 NA|NA|NA P Ferric uptake regulator family MAG.T1.179_01239 1146883.BLASA_1558 1.1e-57 230.3 Frankiales scbA ko:K09815 ko02010,map02010 M00242 ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 Bacteria 2GM1K@201174,4ET8X@85013,COG0803@1,COG0803@2 NA|NA|NA P Belongs to the bacterial solute-binding protein 9 family MAG.T1.179_01240 935866.JAER01000041_gene3044 1.2e-58 233.4 Propionibacteriales mntB ko:K09817 ko02010,map02010 M00242 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.15.3,3.A.1.15.5 Bacteria 2GP3A@201174,4DPIC@85009,COG1121@1,COG1121@2 NA|NA|NA P ATPases associated with a variety of cellular activities MAG.T1.179_01241 1237500.ANBA01000009_gene1397 2.5e-67 262.3 Streptosporangiales ko:K09816 ko02010,map02010 M00242 ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 Bacteria 2GJ7H@201174,4EI6R@85012,COG1108@1,COG1108@2 NA|NA|NA P ABC 3 transport family MAG.T1.179_01242 219305.MCAG_01801 2e-48 199.1 Micromonosporales apl 3.1.3.1 ko:K01077 ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020 M00126 R02135,R04620 RC00017 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 Bacteria 2GN43@201174,4D91R@85008,COG0586@1,COG0586@2 NA|NA|NA S SNARE associated Golgi protein MAG.T1.179_01243 266940.Krad_4341 1e-138 500.7 Actinobacteria mrcB 2.4.1.129,3.4.16.4 ko:K05365,ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 GT51 Bacteria 2GK21@201174,COG0744@1,COG0744@2 NA|NA|NA M penicillin-binding protein MAG.T1.179_01244 33898.JRHJ01000025_gene6653 4e-26 126.7 Actinobacteria Bacteria 2GXEC@201174,COG0739@1,COG0739@2 NA|NA|NA M peptidase MAG.T1.179_01245 585531.HMPREF0063_11333 1.5e-43 183.0 Propionibacteriales Bacteria 2IDJT@201174,4DSNS@85009,COG1309@1,COG1309@2 NA|NA|NA K Bacterial regulatory proteins, tetR family MAG.T1.179_01246 1078020.KEK_17748 6e-25 120.6 Mycobacteriaceae acpS GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008897,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016780,GO:0018070,GO:0018193,GO:0018209,GO:0018215,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901576 2.7.8.7,3.2.1.52 ko:K00997,ko:K01207 ko00520,ko00531,ko00770,ko01100,ko01501,map00520,map00531,map00770,map01100,map01501 M00628 R00022,R01625,R05963,R07809,R07810,R10831 RC00002,RC00049 ko00000,ko00001,ko00002,ko01000 Bacteria 238KS@1762,2IQF6@201174,COG0736@1,COG0736@2 NA|NA|NA I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein MAG.T1.179_01247 1033730.CAHG01000015_gene760 0.0 2077.8 Propionibacteriales fas 2.3.1.179 ko:K09458,ko:K11533 ko00061,ko00780,ko01100,ko01212,ko04931,map00061,map00780,map01100,map01212,map04931 M00082,M00083,M00572 R01624,R01626,R04355,R04428,R04429,R04533,R04534,R04535,R04536,R04537,R04543,R04544,R04566,R04568,R04724,R04726,R04952,R04953,R04954,R04955,R04957,R04958,R04960,R04961,R04963,R04964,R04965,R04966,R04968,R04969,R07762,R07763,R07764,R07765,R10115,R10119,R10700 RC00004,RC00029,RC00039,RC00052,RC00076,RC00117,RC00831,RC01095,RC02727,RC02728,RC02729,RC02857,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 2GIY4@201174,4DN2J@85009,COG0304@1,COG0304@2,COG0331@1,COG0331@2,COG2030@1,COG2030@2,COG4981@1,COG4981@2 NA|NA|NA I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP MAG.T1.179_01248 1003195.SCAT_1341 0.0 1078.9 Actinobacteria glnE GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0030312,GO:0031323,GO:0033238,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0060359,GO:0062012,GO:0065007,GO:0070566,GO:0071944,GO:0080090,GO:1901698 2.7.7.42,2.7.7.89 ko:K00982 ko00000,ko01000 Bacteria 2GJ91@201174,COG1391@1,COG1391@2 NA|NA|NA OT Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell MAG.T1.179_01249 1120950.KB892707_gene4731 9.6e-218 762.7 Propionibacteriales glnA2 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0044464,GO:0050001,GO:0071944 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 Bacteria 2GJ2I@201174,4DNNP@85009,COG0174@1,COG0174@2 NA|NA|NA E glutamine synthetase MAG.T1.179_01250 1048339.KB913029_gene4683 9.2e-221 773.1 Frankiales nadE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5,6.3.5.1 ko:K01916,ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00189,R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 Bacteria 2GK2C@201174,4ESAT@85013,COG0171@1,COG0171@2,COG0388@1,COG0388@2 NA|NA|NA H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source MAG.T1.179_01251 1122137.AQXF01000003_gene2222 1.9e-35 156.4 Alphaproteobacteria yokD 2.3.1.81 ko:K00662 ko00000,ko01000,ko01504 Bacteria 1R68C@1224,2U1PM@28211,COG2746@1,COG2746@2 NA|NA|NA V aminoglycoside MAG.T1.179_01252 1122611.KB903988_gene7185 2.5e-110 405.2 Streptosporangiales panB 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJP6@201174,4EGTN@85012,COG0413@1,COG0413@2 NA|NA|NA H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate MAG.T1.179_01253 1122609.AUGT01000001_gene2813 3.9e-13 80.1 Propionibacteriales Bacteria 2EHMB@1,2I3MM@201174,33BD3@2,4DS27@85009 NA|NA|NA MAG.T1.179_01254 68194.JNXR01000024_gene1245 3.9e-124 451.1 Actinobacteria map GO:0000096,GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0006082,GO:0006464,GO:0006508,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009066,GO:0009987,GO:0010467,GO:0016151,GO:0016485,GO:0016787,GO:0019538,GO:0019752,GO:0030145,GO:0035551,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0046872,GO:0046914,GO:0050897,GO:0051604,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0140096,GO:1901564,GO:1901605 3.4.11.18 ko:K01265 ko00000,ko01000,ko01002 Bacteria 2GKIZ@201174,COG0024@1,COG0024@2 NA|NA|NA E Methionine aminopeptidase MAG.T1.179_01255 1123320.KB889698_gene9298 2.4e-38 165.2 Actinobacteria Bacteria 2GP6A@201174,COG1846@1,COG1846@2 NA|NA|NA K transcriptional regulator MAG.T1.179_01257 253839.SSNG_02891 2.3e-103 382.1 Actinobacteria cbiO ko:K02006,ko:K02008 ko02010,map02010 M00245,M00246 ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 Bacteria 2GJ0M@201174,COG1122@1,COG1122@2 NA|NA|NA P part of an ABC transporter complex. Responsible for energy coupling to the transport system MAG.T1.179_01258 1352941.M877_24670 5.5e-75 287.7 Actinobacteria cbiQ ko:K02006,ko:K02008 ko02010,map02010 M00245,M00246 ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 Bacteria 2GKQ7@201174,COG0619@1,COG0619@2 NA|NA|NA P Cobalt ABC transporter MAG.T1.179_01259 1463909.KL585974_gene2013 1.8e-30 139.8 Actinobacteria 5.4.99.28,5.4.99.29 ko:K06177,ko:K07052 ko00000,ko01000,ko03009,ko03016 Bacteria 2GKRA@201174,COG1266@1,COG1266@2 NA|NA|NA S Abortive infection protein MAG.T1.179_01260 882086.SacxiDRAFT_2995 2.1e-20 105.9 Pseudonocardiales Bacteria 2CK3K@1,2IQJH@201174,32SBH@2,4E5Q5@85010 NA|NA|NA S PFAM Ion channel MAG.T1.179_01261 369723.Strop_2938 7.3e-15 88.2 Micromonosporales ywiC Bacteria 28NT3@1,2IIC3@201174,2ZBRV@2,4DD9K@85008 NA|NA|NA S YwiC-like protein MAG.T1.179_01262 1206731.BAGB01000164_gene4329 4.2e-61 241.5 Nocardiaceae Bacteria 2GM3I@201174,4G8PP@85025,COG1028@1,COG1028@2 NA|NA|NA IQ KR domain MAG.T1.179_01263 1032480.MLP_32170 8.3e-07 60.5 Bacteria ko:K03668,ko:K09914 ko00000 Bacteria COG3187@1,COG3187@2 NA|NA|NA O response to heat MAG.T1.179_01264 243233.MCA1022 9e-130 469.9 Methylococcales cysK GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUBE@1224,1RN6J@1236,1XDN6@135618,COG0031@1,COG0031@2 NA|NA|NA H Belongs to the cysteine synthase cystathionine beta- synthase family MAG.T1.179_01265 926569.ANT_03930 9.1e-66 256.9 Chloroflexi cysE GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009001,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016407,GO:0016412,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 iJN746.PP_0840 Bacteria 2G6DI@200795,COG1045@1,COG1045@2 NA|NA|NA E TIGRFAM serine O-acetyltransferase MAG.T1.179_01267 1242864.D187_006584 4.1e-27 129.4 Proteobacteria cmk 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 1R72B@1224,COG0204@1,COG0204@2 NA|NA|NA I COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase MAG.T1.179_01268 164757.Mjls_1687 1.4e-23 116.3 Mycobacteriaceae Bacteria 23A9W@1762,2DZHZ@1,2IN6I@201174,31ZDG@2 NA|NA|NA MAG.T1.179_01269 471852.Tcur_0543 1.9e-26 127.1 Streptosporangiales Bacteria 2HCHA@201174,4EFUK@85012,COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily MAG.T1.179_01270 1068978.AMETH_3959 6.6e-108 397.1 Pseudonocardiales egtC 3.5.1.118 ko:K07008 ko00340,map00340 R11021 RC00064,RC00090 ko00000,ko00001,ko01000 Bacteria 2GXCD@201174,4DX4A@85010,COG0121@1,COG0121@2 NA|NA|NA S Glutamine amidotransferases class-II MAG.T1.179_01271 1463857.JOFZ01000004_gene2858 1.8e-118 432.6 Actinobacteria bcsA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006629,GO:0006725,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009273,GO:0009698,GO:0009699,GO:0009714,GO:0009715,GO:0009987,GO:0016020,GO:0016043,GO:0019438,GO:0019748,GO:0022607,GO:0032991,GO:0034081,GO:0042180,GO:0042181,GO:0042546,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0071554,GO:0071704,GO:0071766,GO:0071770,GO:0071840,GO:0071944,GO:1901360,GO:1901362,GO:1901576 ko:K16167 ko00000,ko01008 Bacteria 2GV0U@201174,COG3424@1,COG3424@2 NA|NA|NA Q synthase MAG.T1.179_01272 67281.JNZZ01000019_gene123 3.3e-49 201.4 Streptomyces griseus group ypbQ ko:K16168 ko00000,ko01008 Bacteria 2IG52@201174,41AR5@629295,COG1755@1,COG1755@2 NA|NA|NA S Isoprenylcysteine carboxyl methyltransferase (ICMT) family MAG.T1.179_01273 105425.BBPL01000030_gene4521 2.9e-89 335.5 Streptacidiphilus srsC Bacteria 2GM2M@201174,2NGSA@228398,COG0644@1,COG0644@2 NA|NA|NA C FAD dependent oxidoreductase MAG.T1.179_01274 28444.JODQ01000004_gene6201 2.1e-37 162.9 Streptosporangiales ubiA Bacteria 2GJT3@201174,4ENNX@85012,COG0382@1,COG0382@2 NA|NA|NA H UbiA prenyltransferase family MAG.T1.179_01276 1246995.AFR_23530 1e-53 216.1 Micromonosporales Bacteria 2IM3K@201174,4DEGD@85008,COG0517@1,COG0517@2 NA|NA|NA S CBS domain MAG.T1.179_01277 356851.JOAN01000011_gene5380 2.3e-68 266.2 Micromonosporales sod22 Bacteria 2GKCK@201174,4DAWY@85008,COG0025@1,COG0025@2 NA|NA|NA P Sodium/hydrogen exchanger family MAG.T1.179_01278 512565.AMIS_58000 1.6e-49 202.6 Micromonosporales Bacteria 2HF5Y@201174,4DIXE@85008,COG5592@1,COG5592@2 NA|NA|NA S Hemerythrin HHE cation binding domain MAG.T1.179_01279 47839.CCAU010000009_gene1334 3.9e-33 147.5 Mycobacteriaceae Bacteria 23A2K@1762,2IC9E@201174,COG2105@1,COG2105@2 NA|NA|NA S Gamma-glutamyl cyclotransferase, AIG2-like MAG.T1.179_01280 500153.JOEK01000009_gene5174 5.5e-55 221.5 Actinobacteria rfaF ko:K02843 ko00540,ko01100,map00540,map01100 M00080 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 GT9 Bacteria 2GMZG@201174,COG0859@1,COG0859@2 NA|NA|NA M PFAM glycosyl transferase family 9 MAG.T1.179_01282 1050202.KB913024_gene1971 2e-50 207.2 Actinopolysporales sigB GO:0000988,GO:0000990,GO:0003674,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0043620,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141 ko:K03090 ko00000,ko03021 Bacteria 2GKSY@201174,407GP@622450,COG1191@1,COG1191@2 NA|NA|NA K Sigma-70 region 3 MAG.T1.179_01285 345341.KUTG_02431 2.1e-128 466.1 Pseudonocardiales Bacteria 2HNS8@201174,4EA2Q@85010,COG2152@1,COG2152@2 NA|NA|NA G beta-1,4-mannooligosaccharide phosphorylase MAG.T1.179_01286 345341.KUTG_02430 6.9e-32 143.7 Actinobacteria Bacteria 2I5YD@201174,COG1331@1,COG1331@2 NA|NA|NA O Highly conserved protein containing a thioredoxin domain MAG.T1.179_01287 710696.Intca_3045 6.7e-98 364.8 Intrasporangiaceae Bacteria 2GNPG@201174,4FJ4K@85021,COG0438@1,COG0438@2 NA|NA|NA M Glycosyl transferase MAG.T1.179_01288 390989.JOEG01000003_gene4476 7.8e-50 204.5 Micromonosporales Bacteria 2HSM4@201174,4DFKR@85008,COG1295@1,COG1295@2 NA|NA|NA S Virulence factor BrkB MAG.T1.179_01290 2045.KR76_01350 1.3e-62 246.5 Propionibacteriales Bacteria 2GKCX@201174,4DPXK@85009,COG0457@1,COG0457@2,COG4995@1,COG4995@2 NA|NA|NA K CHAT domain MAG.T1.179_01291 1077972.ARGLB_083_00470 7.1e-33 149.8 Actinobacteria Bacteria 2EIJM@1,2IREQ@201174,33CAY@2 NA|NA|NA MAG.T1.179_01292 397278.JOJN01000007_gene3349 2.4e-137 496.1 Propionibacteriales ydaM Bacteria 2GNN5@201174,4DWKW@85009,COG1215@1,COG1215@2 NA|NA|NA M Glycosyl transferase family group 2 MAG.T1.179_01293 1283287.KB822582_gene2986 5.1e-75 288.5 Actinobacteria Bacteria 2GP6W@201174,COG1835@1,COG1835@2 NA|NA|NA I Acyltransferase MAG.T1.179_01294 649831.L083_3893 2.4e-106 392.9 Micromonosporales gba 3.2.1.45 ko:K01201 ko00511,ko00600,ko01100,ko04142,map00511,map00600,map01100,map04142 R01498 RC00059,RC00451 ko00000,ko00001,ko01000 GH30 Bacteria 2GMWN@201174,4D9UI@85008,COG5520@1,COG5520@2 NA|NA|NA G Glycosyl hydrolase family 30 beta sandwich domain MAG.T1.179_01295 1120959.ATXF01000011_gene239 2.4e-11 76.3 Microbacteriaceae 3.1.3.48 ko:K01104 ko00000,ko01000 Bacteria 2GMPR@201174,4FPK5@85023,COG0394@1,COG0394@2 NA|NA|NA T Low molecular weight phosphatase family MAG.T1.179_01296 500153.JOEK01000002_gene442 4e-23 114.4 Actinobacteria rshA 2.7.11.1 ko:K04757 ko00000,ko01000,ko01001,ko03021 Bacteria 2IFG9@201174,COG2172@1,COG2172@2 NA|NA|NA T anti-sigma regulatory factor MAG.T1.179_01297 222534.KB893670_gene3630 1.2e-89 337.0 Frankiales sigB GO:0000988,GO:0000990,GO:0003674,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0043620,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141 ko:K03090 ko00000,ko03021 Bacteria 2GKSY@201174,4ES7X@85013,COG1191@1,COG1191@2 NA|NA|NA K RNA polymerase MAG.T1.179_01299 1123320.KB889737_gene5367 1.1e-70 273.9 Actinobacteria Bacteria 2GJ3K@201174,COG1597@1,COG1597@2 NA|NA|NA I Diacylglycerol kinase MAG.T1.179_01300 1283283.ATXA01000002_gene2799 5.9e-36 156.4 Frankiales whiB GO:0000302,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0015035,GO:0015036,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042221,GO:0042493,GO:0045892,GO:0045934,GO:0047134,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0060255,GO:0065007,GO:0071731,GO:0080090,GO:0097159,GO:0097366,GO:1901363,GO:1901698,GO:1901700,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 ko:K18955 ko00000,ko03000 Bacteria 2DMIE@1,2IQCG@201174,32RSG@2,4ET35@85013 NA|NA|NA K Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA MAG.T1.179_01301 28444.JODQ01000015_gene1617 1.4e-100 373.6 Streptosporangiales pdtaS GO:0000155,GO:0000160,GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005524,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0017076,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 2.7.13.3 ko:K00936 M00839 ko00000,ko00002,ko01000,ko01001,ko02022 Bacteria 2GKMP@201174,4EG9F@85012,COG3920@1,COG3920@2 NA|NA|NA T Histidine kinase MAG.T1.179_01302 1123320.KB889733_gene6240 4e-102 378.3 Actinobacteria 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 Bacteria 2GP4W@201174,COG0449@1,COG0449@2 NA|NA|NA M PFAM Sugar isomerase (SIS) MAG.T1.179_01303 68194.JNXR01000016_gene7360 9.4e-20 103.2 Actinobacteria Bacteria 2IKZP@201174,COG5496@1,COG5496@2 NA|NA|NA S Thioesterase MAG.T1.179_01304 351607.Acel_0550 1.1e-158 566.2 Frankiales pilT ko:K02669 ko00000,ko02035,ko02044 3.A.15.2 Bacteria 2HPWY@201174,4EUA1@85013,COG2805@1,COG2805@2 NA|NA|NA NU Type II/IV secretion system protein MAG.T1.179_01305 1385518.N798_03110 2e-23 115.5 Intrasporangiaceae Bacteria 2DRYE@1,2IS24@201174,33DPC@2,4FHPE@85021 NA|NA|NA MAG.T1.179_01306 1192034.CAP_5004 4.7e-23 114.4 Myxococcales Bacteria 1NBEP@1224,2E4IQ@1,2WW82@28221,2YVWC@29,32ZDS@2,431T4@68525 NA|NA|NA MAG.T1.179_01307 351607.Acel_0539 6.4e-18 96.7 Frankiales rsrA GO:0000988,GO:0000989,GO:0003674,GO:0005488,GO:0006950,GO:0006979,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009593,GO:0009628,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032502,GO:0042221,GO:0043167,GO:0043169,GO:0043934,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051606,GO:0051775,GO:0051776,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141 Bacteria 2IM2X@201174,4ETFE@85013,COG5662@1,COG5662@2 NA|NA|NA K anti-sigma factor MAG.T1.179_01308 446471.Xcel_2492 3.3e-81 308.1 Promicromonosporaceae sigH GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141 ko:K03088 ko00000,ko03021 Bacteria 2GJ02@201174,4F3JN@85017,COG1595@1,COG1595@2 NA|NA|NA K Sigma-70, region 4 MAG.T1.179_01311 1380346.JNIH01000001_gene4275 5.8e-41 174.5 Actinobacteria ko:K07020 ko00000 Bacteria 2GKKE@201174,COG3571@1,COG3571@2 NA|NA|NA S Hydrolase of the alpha beta-hydrolase MAG.T1.179_01312 469371.Tbis_2926 1.1e-66 260.0 Pseudonocardiales Bacteria 2GKY8@201174,4E13E@85010,COG2135@1,COG2135@2 NA|NA|NA S Belongs to the SOS response-associated peptidase family MAG.T1.179_01313 1429046.RR21198_0802 2.9e-142 511.9 Nocardiaceae aroA GO:0003674,GO:0003824,GO:0003866,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:0071944,GO:1901576 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJKX@201174,4FU48@85025,COG0128@1,COG0128@2 NA|NA|NA E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate MAG.T1.179_01314 1385518.N798_08960 9.8e-106 390.2 Intrasporangiaceae rsgA 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 Bacteria 2GJ37@201174,4FEQ3@85021,COG1162@1,COG1162@2 NA|NA|NA S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit MAG.T1.179_01316 1463841.JOIR01000009_gene4116 6.6e-78 297.4 Actinobacteria hisN GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042578,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.1.3.15 ko:K05602 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03013 RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKZZ@201174,COG0483@1,COG0483@2 NA|NA|NA G inositol monophosphatase MAG.T1.179_01318 235985.BBPN01000033_gene11 1.9e-65 256.1 Streptacidiphilus Bacteria 2GKUU@201174,2NH2E@228398,COG3173@1,COG3173@2 NA|NA|NA S Phosphotransferase enzyme family MAG.T1.179_01319 1306174.JODP01000006_gene3393 1.3e-28 132.9 Actinobacteria Bacteria 2IHPB@201174,COG0517@1,COG0517@2 NA|NA|NA S Cbs domain MAG.T1.179_01320 926560.KE387023_gene3341 9.5e-85 320.9 Deinococcus-Thermus cyp132 1.14.15.24 ko:K22492 ko00906,map00906 R07558,R07559,R09747 RC00478,RC02629 ko00000,ko00001,ko00199,ko01000 Bacteria 1WIX6@1297,COG2124@1,COG2124@2 NA|NA|NA Q cytochrome P450 MAG.T1.179_01321 1172180.KB911793_gene3537 8.1e-107 393.7 Actinobacteria Bacteria 2GKRN@201174,COG2326@1,COG2326@2 NA|NA|NA G polyphosphate kinase MAG.T1.179_01323 1211815.CBYP010000036_gene2210 4e-62 245.7 Frankiales Bacteria 2GK1J@201174,4ERY7@85013,COG0642@1,COG2205@2 NA|NA|NA T PhoQ Sensor MAG.T1.179_01324 1313172.YM304_19260 3.4e-54 218.4 Acidimicrobiia Bacteria 2GKFS@201174,4CMYH@84992,COG0745@1,COG0745@2 NA|NA|NA K Transcriptional regulatory protein, C terminal MAG.T1.179_01325 1380370.JIBA01000005_gene614 2.9e-63 248.8 Intrasporangiaceae Bacteria 2IMQQ@201174,4FFD0@85021,COG2267@1,COG2267@2 NA|NA|NA I Serine aminopeptidase, S33 MAG.T1.179_01326 188626.HMPREF0321_0345 2.4e-117 429.5 Dermacoccaceae deaD 3.6.4.13 ko:K05592,ko:K11927 ko03018,map03018 ko00000,ko00001,ko01000,ko03009,ko03019 Bacteria 1ZVH9@145357,2GIUR@201174,COG0513@1,COG0513@2 NA|NA|NA L helicase superfamily c-terminal domain MAG.T1.179_01327 494419.ALPM01000021_gene79 1.5e-113 417.2 Micrococcaceae Bacteria 1WB1I@1268,2GIZF@201174,COG5001@1,COG5001@2 NA|NA|NA T diguanylate cyclase MAG.T1.179_01328 1123320.KB889629_gene7866 9.5e-15 86.7 Actinobacteria Bacteria 2GVSD@201174,COG1714@1,COG1714@2 NA|NA|NA S RDD family MAG.T1.179_01329 471853.Bcav_1837 4.6e-179 634.4 Actinobacteria hutH 4.3.1.3 ko:K01745 ko00340,ko01100,map00340,map01100 M00045 R01168 RC00361 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJZW@201174,COG2986@1,COG2986@2 NA|NA|NA E Histidine ammonia-lyase MAG.T1.179_01330 1192034.CAP_2819 1.4e-24 120.6 Myxococcales Bacteria 1NAQM@1224,2WNXU@28221,2YVQF@29,42RR6@68525,COG1946@1,COG1946@2 NA|NA|NA I Thioesterase-like superfamily MAG.T1.179_01331 644283.Micau_1166 2e-260 904.8 Micromonosporales hutU 4.2.1.49 ko:K01712 ko00340,ko01100,map00340,map01100 M00045 R02914 RC00804 ko00000,ko00001,ko00002,ko01000 Bacteria 2GP10@201174,4D9Y2@85008,COG2987@1,COG2987@2 NA|NA|NA E Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate MAG.T1.179_01332 644283.Micau_1163 1.4e-143 516.2 Micromonosporales hutI GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006547,GO:0006548,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046395,GO:0046483,GO:0046700,GO:0052803,GO:0052805,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 3.5.2.7 ko:K01468 ko00340,ko01100,map00340,map01100 M00045 R02288 RC00683 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJH4@201174,4DBJ2@85008,COG1228@1,COG1228@2 NA|NA|NA Q hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides MAG.T1.179_01333 1120960.ATXG01000004_gene1805 3.2e-87 328.6 Microbacteriaceae hutG 3.5.3.11,3.5.3.8 ko:K01479,ko:K01480 ko00330,ko00340,ko01100,map00330,map00340,map01100 M00045,M00133 R01157,R02285 RC00024,RC00221,RC00329,RC00681 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJA6@201174,4FKS9@85023,COG0010@1,COG0010@2 NA|NA|NA E Arginase family MAG.T1.179_01334 1304865.JAGF01000001_gene497 2.3e-71 275.8 Actinobacteria Bacteria 2GQC1@201174,COG2267@1,COG2267@2 NA|NA|NA I Alpha beta hydrolase MAG.T1.179_01335 312284.A20C1_11546 1.4e-45 189.5 unclassified Actinobacteria (class) Bacteria 2HP5X@201174,3UXNT@52018,COG1309@1,COG1309@2 NA|NA|NA K WHG domain MAG.T1.179_01336 796942.HMPREF9623_01830 2.7e-70 272.3 Clostridia Bacteria 1TSAT@1239,24A6W@186801,COG0535@1,COG0535@2 NA|NA|NA S radical SAM domain protein MAG.T1.179_01338 1211815.CBYP010000051_gene683 3.3e-20 105.5 Frankiales ko:K03265 ko03015,map03015 ko00000,ko00001,ko03012,ko03019 Bacteria 2IFQH@201174,4ET50@85013,COG1503@1,COG1503@2 NA|NA|NA J translation release factor activity MAG.T1.179_01339 44060.JODL01000025_gene142 3.7e-39 168.3 Actinobacteria Bacteria 2GNIP@201174,COG1309@1,COG1309@2 NA|NA|NA K transcriptional regulator MAG.T1.179_01340 909613.UO65_3763 3.4e-265 921.0 Pseudonocardiales fadB 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ50@201174,4E0TU@85010,COG1024@1,COG1024@2,COG1250@1,COG1250@2 NA|NA|NA I 3-hydroxyacyl-CoA dehydrogenase MAG.T1.179_01341 909613.UO65_3764 5.4e-175 620.5 Pseudonocardiales 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GJAC@201174,4DXDP@85010,COG0183@1,COG0183@2 NA|NA|NA I Belongs to the thiolase family MAG.T1.179_01342 1278078.G419_22134 0.0 1185.2 Nocardiaceae 3.6.3.8 ko:K01537 ko00000,ko01000 3.A.3.2 Bacteria 2GJJC@201174,4FU7Y@85025,COG0474@1,COG0474@2 NA|NA|NA P PFAM E1-E2 ATPase-associated domain protein, Haloacid dehalogenase domain protein hydrolase, cation transporting ATPase domain protein MAG.T1.179_01343 479431.Namu_1914 9.4e-104 383.3 Frankiales nagD ko:K02566 ko00000 Bacteria 2GJG6@201174,4EU6R@85013,COG0647@1,COG0647@2 NA|NA|NA G Belongs to the HAD-like hydrolase superfamily MAG.T1.179_01344 479431.Namu_1913 1.2e-114 419.9 Actinobacteria egsA 1.1.1.261 ko:K00096 ko00564,map00564 R05679,R05680 RC00029 ko00000,ko00001,ko01000 Bacteria 2GKWA@201174,COG0371@1,COG0371@2 NA|NA|NA C Dehydrogenase MAG.T1.179_01345 1123320.KB889667_gene2958 1.5e-241 842.0 Actinobacteria arc GO:0000302,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0010499,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0019941,GO:0022623,GO:0022624,GO:0030163,GO:0030312,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042802,GO:0043170,GO:0043335,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0044877,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070628,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097366,GO:0140030,GO:0140035,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:1902494,GO:1905368,GO:1905369 ko:K13527 ko03050,map03050 M00342 ko00000,ko00001,ko00002,ko03051 Bacteria 2GMR1@201174,COG1222@1,COG1222@2 NA|NA|NA O AAA ATPase forming ring-shaped complexes MAG.T1.179_01346 1137269.AZWL01000002_gene6306 1.5e-112 412.9 Actinobacteria trmI GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016426,GO:0016429,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.219,2.1.1.220 ko:K07442 ko00000,ko01000,ko03016 Bacteria 2GJPD@201174,COG2519@1,COG2519@2 NA|NA|NA J Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA MAG.T1.179_01347 1120950.KB892708_gene4422 8.8e-63 247.7 Propionibacteriales Bacteria 2GJBZ@201174,4DNGY@85009,COG1994@1,COG1994@2 NA|NA|NA S Belongs to the peptidase M50B family MAG.T1.179_01348 479435.Kfla_3207 8.2e-90 337.0 Propionibacteriales recB 3.6.4.12 ko:K03657,ko:K07465 ko03420,ko03430,map03420,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 2GJC5@201174,4DP6M@85009,COG2887@1,COG2887@2 NA|NA|NA L Protein of unknown function (DUF2800) MAG.T1.179_01349 1380393.JHVP01000004_gene618 4.3e-174 618.6 Frankiales ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 2H37M@201174,4ERZ6@85013,COG3127@1,COG3127@2 NA|NA|NA Q MacB-like periplasmic core domain MAG.T1.179_01350 1385519.N801_08145 2.1e-93 349.0 Intrasporangiaceae ko:K02003 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GJN6@201174,4FF61@85021,COG1136@1,COG1136@2 NA|NA|NA V ABC transporter, ATP-binding protein MAG.T1.179_01351 1120936.KB907219_gene3210 1e-40 173.7 Streptosporangiales hisE Bacteria 2GJNG@201174,4EITJ@85012,COG0637@1,COG0637@2 NA|NA|NA S Haloacid dehalogenase-like hydrolase MAG.T1.179_01352 471852.Tcur_2292 0.0 1637.9 Streptosporangiales metH GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0030312,GO:0032259,GO:0042084,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 Bacteria 2GM5Q@201174,4EFW6@85012,COG0646@1,COG0646@2,COG1410@1,COG1410@2 NA|NA|NA E B12 binding domain MAG.T1.179_01354 1137269.AZWL01000042_gene1229 4e-37 162.2 Actinobacteria Bacteria 2DVVA@1,2IHH0@201174,32V07@2 NA|NA|NA MAG.T1.179_01355 1121372.AULK01000004_gene1325 1.2e-21 111.3 Microbacteriaceae Bacteria 2GU7G@201174,4FMTP@85023,COG1403@1,COG1403@2 NA|NA|NA V Domain of unknown function (DUF222) MAG.T1.179_01356 219305.MCAG_00437 5.8e-201 707.2 Micromonosporales pgi GO:0003674,GO:0003824,GO:0004347,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GJG0@201174,4DBW4@85008,COG0166@1,COG0166@2 NA|NA|NA G Belongs to the GPI family MAG.T1.179_01357 446468.Ndas_1544 8.1e-142 510.4 Streptosporangiales cysS GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010125,GO:0010126,GO:0010467,GO:0016020,GO:0016070,GO:0016137,GO:0016138,GO:0016874,GO:0016875,GO:0016879,GO:0016880,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035446,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.1.1.16,6.3.1.13 ko:K01883,ko:K15526 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iNJ661.Rv2130c Bacteria 2GJZR@201174,4EH1Y@85012,COG0215@1,COG0215@2 NA|NA|NA J Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins MAG.T1.179_01358 591157.SSLG_01071 2.1e-31 142.9 Actinobacteria surf1 ko:K14998 ko00000,ko03029 3.D.4.8 Bacteria 2GR90@201174,COG3346@1,COG3346@2 NA|NA|NA S SURF1-like protein MAG.T1.179_01359 1035308.AQYY01000002_gene664 2.6e-32 145.6 Bacteria Bacteria COG5274@1,COG5274@2 NA|NA|NA C heme binding MAG.T1.179_01360 1120950.KB892747_gene3703 1.1e-66 260.0 Propionibacteriales 3.1.3.10 ko:K07025,ko:K20866 ko00010,ko01120,map00010,map01120 R00947 RC00078 ko00000,ko00001,ko01000 Bacteria 2HZ7F@201174,4DQFA@85009,COG1011@1,COG1011@2 NA|NA|NA S HAD-superfamily hydrolase, subfamily IA, variant 1 MAG.T1.179_01361 479431.Namu_2200 1.9e-240 838.6 Frankiales proS GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 2GJ9G@201174,4ERXH@85013,COG0442@1,COG0442@2 NA|NA|NA J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS MAG.T1.179_01362 66377.JOBH01000024_gene3357 1.3e-79 303.1 Actinobacteria ko:K06976 ko00000 Bacteria 2GMD2@201174,COG3393@1,COG3393@2 NA|NA|NA S acetyltransferase MAG.T1.179_01363 1123256.KB907927_gene1736 6e-87 327.8 Xanthomonadales adhA 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 Bacteria 1MUTT@1224,1RPQC@1236,1X31K@135614,COG1064@1,COG1064@2 NA|NA|NA S Alcohol dehydrogenase GroES-like domain MAG.T1.179_01365 1306174.JODP01000021_gene193 2.9e-101 375.6 Actinobacteria ko:K06946 ko00000 Bacteria 2IES1@201174,COG3596@1,COG3596@2,COG3597@1,COG3597@2 NA|NA|NA D Domain of unknown function (DUF697) MAG.T1.179_01366 40571.JOEA01000017_gene507 2.2e-178 631.7 Pseudonocardiales ispG GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009055,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0022900,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS06430,iJN678.gcpE Bacteria 2GK2S@201174,4DZX0@85010,COG0821@1,COG0821@2 NA|NA|NA I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate MAG.T1.179_01367 1123052.AUDF01000012_gene812 1.1e-25 124.0 Microbacteriaceae ko:K07090 ko00000 Bacteria 2I5VT@201174,4FNYV@85023,COG0730@1,COG0730@2 NA|NA|NA S Sulfite exporter TauE/SafE MAG.T1.179_01368 1386089.N865_16260 1.7e-100 373.2 Intrasporangiaceae rseP ko:K11749 ko02024,ko04112,map02024,map04112 ko00000,ko00001,ko01000,ko01002 Bacteria 2GJJT@201174,4FEQK@85021,COG0750@1,COG0750@2 NA|NA|NA M Peptidase family M50 MAG.T1.179_01369 471852.Tcur_3372 7.5e-137 493.8 Streptosporangiales dxr GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0050897,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 iAPECO1_1312.APECO1_1814,iECOK1_1307.ECOK1_0174,iECS88_1305.ECS88_0183,iHN637.CLJU_RS06420,iNJ661.Rv2870c,iUMN146_1321.UM146_23670,iUTI89_1310.UTI89_C0188 Bacteria 2GIRV@201174,4EGGZ@85012,COG0743@1,COG0743@2 NA|NA|NA I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) MAG.T1.179_01370 105422.BBPM01000100_gene5239 1.6e-181 642.5 Streptacidiphilus 1.2.1.3,1.2.1.9 ko:K00128,ko:K00131 ko00010,ko00030,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130,map01200 M00135,M00308,M00633 R00264,R00631,R00710,R00904,R01058,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIWZ@201174,2NG4B@228398,COG1012@1,COG1012@2 NA|NA|NA C Aldehyde dehydrogenase family MAG.T1.179_01371 1380347.JNII01000005_gene3136 6.2e-180 637.1 Frankiales gabT 2.6.1.19,2.6.1.22 ko:K00823,ko:K07250 ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120 M00027 R00908,R01648,R04188 RC00006,RC00062,RC00160 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 2GIS9@201174,4ERVR@85013,COG0160@1,COG0160@2 NA|NA|NA E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family MAG.T1.179_01372 521045.Kole_0725 1.9e-53 216.9 Thermotogae hemN1 Bacteria 2GDT0@200918,COG0635@1,COG0635@2 NA|NA|NA C Elongator protein 3, MiaB family, Radical SAM MAG.T1.179_01373 1449058.JQKT01000007_gene1901 2.3e-170 605.1 Microbacteriaceae lys1 Bacteria 2GMQ1@201174,4FKWT@85023,COG1748@1,COG1748@2 NA|NA|NA E Saccharopine dehydrogenase C-terminal domain MAG.T1.179_01374 1487953.JMKF01000043_gene2606 2.7e-25 122.1 Cyanobacteria ko:K03712 ko00000,ko03000 Bacteria 1G8VK@1117,COG1846@1,COG1846@2 NA|NA|NA K helix_turn_helix multiple antibiotic resistance protein MAG.T1.179_01376 1454010.JEOE01000007_gene2007 2.1e-85 322.8 Cellulomonadaceae 2.8.1.7,4.4.1.16 ko:K03980,ko:K11717 ko00450,ko01100,map00450,map01100 R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000,ko01011,ko02000 2.A.66.4 Bacteria 2I44K@201174,4F1AQ@85016,COG3266@1,COG3266@2 NA|NA|NA S domain, Protein MAG.T1.179_01377 479435.Kfla_1695 1e-218 766.1 Propionibacteriales mmsA 1.2.1.18,1.2.1.27 ko:K00140 ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200 M00013 R00705,R00706,R00922,R00935 RC00004,RC02723,RC02817 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJI2@201174,4DNVW@85009,COG1012@1,COG1012@2 NA|NA|NA C Aldehyde dehydrogenase family MAG.T1.179_01378 1157637.KB892115_gene4645 1.1e-158 566.6 Actinobacteria Bacteria 2GJQ9@201174,COG0665@1,COG0665@2 NA|NA|NA E FAD dependent oxidoreductase MAG.T1.179_01379 570268.ANBB01000037_gene2671 5e-57 229.2 Streptosporangiales Bacteria 2GIV0@201174,4EM8V@85012,COG0515@1,COG0515@2 NA|NA|NA KLT SMART serine threonine protein kinase MAG.T1.179_01380 670487.Ocepr_1979 3.1e-17 95.9 Deinococcus-Thermus rlmN GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 ko:K06941 ko00000,ko01000,ko03009 Bacteria 1WICE@1297,COG0820@1,COG0820@2 NA|NA|NA J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs MAG.T1.179_01381 1504319.GM45_4540 3e-95 355.1 unclassified Actinobacteria (class) potC ko:K11070 ko02010,map02010 M00299 ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 Bacteria 2GJ6Q@201174,3UWPB@52018,COG1177@1,COG1177@2 NA|NA|NA P COG1177 ABC-type spermidine putrescine transport system, permease component II MAG.T1.179_01382 1504319.GM45_4535 6.2e-99 367.5 unclassified Actinobacteria (class) potH ko:K11071 ko02010,map02010 M00299 ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 Bacteria 2GJ5G@201174,3UWG9@52018,COG1176@1,COG1176@2 NA|NA|NA P COG1176 ABC-type spermidine putrescine transport system, permease component I MAG.T1.179_01383 105420.BBPO01000072_gene4006 5e-133 481.1 Streptacidiphilus potA 3.6.3.31 ko:K11072 ko02010,map02010 M00299 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.11.1 Bacteria 2GJCM@201174,2NG9M@228398,COG3842@1,COG3842@2 NA|NA|NA E TOBE domain MAG.T1.179_01384 1504319.GM45_4525 2.3e-117 429.1 unclassified Actinobacteria (class) ko:K11069 ko02010,map02010 M00299 ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 Bacteria 2GKVG@201174,3UWJS@52018,COG0687@1,COG0687@2 NA|NA|NA E Bacterial extracellular solute-binding protein MAG.T1.179_01385 37919.EP51_00995 9.7e-195 686.4 Nocardiaceae 1.2.1.8 ko:K00130 ko00260,ko01100,map00260,map01100 M00555 R02565,R02566 RC00080 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIWZ@201174,4FTXB@85025,COG1012@1,COG1012@2 NA|NA|NA C Belongs to the aldehyde dehydrogenase family MAG.T1.179_01386 1396141.BATP01000059_gene2437 3.2e-109 401.7 Verrucomicrobiae ldhA 1.1.1.28 ko:K03778 ko00620,ko01120,map00620,map01120 R00704 RC00044 ko00000,ko00001,ko01000 Bacteria 2ITY0@203494,46SGM@74201,COG1052@1,COG1052@2 NA|NA|NA CH D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain MAG.T1.179_01387 526225.Gobs_1721 1.9e-211 741.9 Frankiales 1.2.1.8 ko:K00130 ko00260,ko01100,map00260,map01100 M00555 R02565,R02566 RC00080 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIWZ@201174,4ERRA@85013,COG1012@1,COG1012@2 NA|NA|NA C Belongs to the aldehyde dehydrogenase family MAG.T1.179_01388 1380354.JIAN01000007_gene161 2e-59 235.3 Actinobacteria asnC ko:K03718 ko00000,ko03000 Bacteria 2GP1P@201174,COG1522@1,COG1522@2 NA|NA|NA K AsnC family MAG.T1.179_01390 1463856.JOHY01000007_gene716 3.9e-68 264.6 Actinobacteria orn GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360 ko:K13288 ko03008,map03008 ko00000,ko00001,ko01000,ko03009,ko03019 Bacteria 2GJR7@201174,COG1949@1,COG1949@2 NA|NA|NA L 3'-to-5' exoribonuclease specific for small oligoribonucleotides MAG.T1.179_01391 404589.Anae109_2437 7.9e-13 80.5 Myxococcales ko:K04767,ko:K07168,ko:K07182 ko00000 Bacteria 1N0EB@1224,2WRIB@28221,2YVSI@29,42W96@68525,COG0517@1,COG0517@2 NA|NA|NA S CBS domain MAG.T1.179_01392 1125863.JAFN01000001_gene2799 8.3e-35 153.3 Deltaproteobacteria tesC GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016289,GO:0016787,GO:0016788,GO:0016790,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0047617,GO:0055114,GO:0071704,GO:0072329,GO:1901575 ko:K07107,ko:K12500 ko00000,ko01000,ko01004 Bacteria 1REIH@1224,2WQAZ@28221,42UZ3@68525,COG0824@1,COG0824@2 NA|NA|NA S Thioesterase-like superfamily MAG.T1.179_01393 2002.JOEQ01000005_gene3672 7.5e-185 654.1 Streptosporangiales Bacteria 2I3HX@201174,4EHKS@85012,COG0421@1,COG0421@2 NA|NA|NA E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine MAG.T1.179_01394 1237500.ANBA01000033_gene4471 7.2e-145 520.8 Streptosporangiales ada 3.2.2.21 ko:K13529,ko:K15051 ko03410,map03410 ko00000,ko00001,ko01000,ko03000,ko03400 Bacteria 2GITG@201174,4EGE3@85012,COG0122@1,COG0122@2,COG2169@1,COG2169@2 NA|NA|NA FL AlkA N-terminal domain MAG.T1.179_01395 1192759.AKIB01000096_gene1609 1.5e-37 162.9 Sphingomonadales ogt 1.17.99.6,2.1.1.63 ko:K00567,ko:K18979 ko00000,ko01000,ko03016,ko03400 Bacteria 1N2YQ@1224,2KD23@204457,2TRRN@28211,COG0350@1,COG0350@2 NA|NA|NA L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated MAG.T1.179_01397 1121017.AUFG01000013_gene1927 6.9e-188 664.1 Intrasporangiaceae feoB ko:K04759 ko00000,ko02000 9.A.8.1 Bacteria 2GTV2@201174,4FIUH@85021,COG0370@1,COG0370@2 NA|NA|NA P Ferrous iron transport protein B C terminus MAG.T1.179_01399 37919.EP51_17595 2.7e-181 642.5 Nocardiaceae Bacteria 2GJPU@201174,4FTWD@85025,COG1807@1,COG1807@2 NA|NA|NA M Dolichyl-phosphate-mannose-protein mannosyltransferase MAG.T1.179_01400 675635.Psed_5033 2.5e-144 518.8 Pseudonocardiales ko:K07015 ko00000 Bacteria 2GJTE@201174,4DYC7@85010,COG1215@1,COG1215@2,COG2246@1,COG2246@2 NA|NA|NA M GtrA-like protein MAG.T1.179_01401 1380356.JNIK01000018_gene799 1.6e-94 352.4 Frankiales Bacteria 2GIZB@201174,4ERG0@85013,COG0745@1,COG0745@2 NA|NA|NA T Two component transcriptional regulator, winged helix family MAG.T1.179_01402 1435356.Y013_11045 1.5e-95 357.1 Nocardiaceae phoR 2.7.13.3 ko:K02484,ko:K07768 ko02020,map02020 M00443 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 2I2DU@201174,4FTXC@85025,COG5002@1,COG5002@2 NA|NA|NA T His Kinase A (phosphoacceptor) domain MAG.T1.179_01403 1394178.AWOO02000024_gene5655 3.5e-27 129.8 Streptosporangiales Bacteria 2HV9N@201174,4EINQ@85012,COG5555@1,COG5555@2 NA|NA|NA N Belongs to the peptidase S8 family MAG.T1.179_01404 1121946.AUAX01000005_gene5163 8.1e-59 234.6 Micromonosporales Bacteria 2GIR7@201174,4D95J@85008,COG4129@1,COG4129@2 NA|NA|NA S Evidence 4 Homologs of previously reported genes of MAG.T1.179_01405 479431.Namu_0355 9.7e-10 68.2 Actinobacteria Bacteria 2EGTM@1,2GWY1@201174,33AJR@2 NA|NA|NA MAG.T1.179_01406 446465.Bfae_27530 7.6e-79 301.2 Dermabacteraceae yqhO GO:0003674,GO:0003824,GO:0016787 ko:K07001 ko00000 Bacteria 2IA6V@201174,4FC03@85020,COG1752@1,COG1752@2 NA|NA|NA S Patatin-like phospholipase MAG.T1.179_01407 1304865.JAGF01000001_gene3499 2.2e-102 379.0 Actinobacteria corA ko:K03284 ko00000,ko02000 1.A.35.1,1.A.35.3 Bacteria 2IB0N@201174,COG0598@1,COG0598@2 NA|NA|NA P PFAM Mg2 transporter protein CorA family protein MAG.T1.179_01408 1463903.JOIZ01000010_gene3653 1.1e-52 213.4 Actinobacteria Bacteria 2GJ2N@201174,COG0745@1,COG0745@2 NA|NA|NA T response regulator, receiver MAG.T1.179_01409 219305.MCAG_00090 6.2e-47 195.3 Micromonosporales Bacteria 2GJKC@201174,4DHA1@85008,COG0642@1,COG2205@2 NA|NA|NA T Domain of unknown function (DUF4118) MAG.T1.179_01410 219305.MCAG_00089 5.3e-201 707.6 Micromonosporales ydaO Bacteria 2GK5V@201174,4DI99@85008,COG0531@1,COG0531@2 NA|NA|NA E Amino acid permease MAG.T1.179_01411 1150399.AQYK01000001_gene352 3.3e-54 218.4 Microbacteriaceae yfbT GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0030145,GO:0042578,GO:0043136,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050084,GO:0050286,GO:0050308,GO:0050897 3.1.3.23 ko:K19270 ko00000,ko01000 Bacteria 2GNX0@201174,4FPH8@85023,COG0637@1,COG0637@2 NA|NA|NA V Haloacid dehalogenase-like hydrolase MAG.T1.179_01412 1172188.KB911822_gene720 8.1e-50 203.4 Intrasporangiaceae ko:K09763 ko00000 Bacteria 2IHUS@201174,4FH6W@85021,COG1547@1,COG1547@2 NA|NA|NA S Domain of unknown function (DUF309) MAG.T1.179_01414 1227261.HMPREF0043_00810 3.9e-07 60.8 Actinobacteria Bacteria 2GITW@201174,4D39J@85005,COG1167@1,COG1167@2 NA|NA|NA EK Aminotransferase, class I II MAG.T1.179_01416 1035308.AQYY01000001_gene3069 1.4e-123 449.9 Clostridia hemG 1.3.3.15,1.3.3.4 ko:K00231 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03222,R04178 RC00885 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQ6W@1239,24IHQ@186801,COG1232@1,COG1232@2 NA|NA|NA H Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX MAG.T1.179_01417 446471.Xcel_3125 2.6e-136 491.9 Actinobacteria pqqE ko:K22227 ko00000 Bacteria 2GNSY@201174,COG0535@1,COG0535@2 NA|NA|NA C Radical SAM MAG.T1.179_01418 266940.Krad_1273 2e-10 72.0 Actinobacteria Bacteria 2E3JG@1,2GU6T@201174,32YHV@2 NA|NA|NA MAG.T1.179_01419 479435.Kfla_5917 3.8e-154 551.6 Propionibacteriales yjcD GO:0003674,GO:0005215,GO:0005345,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006863,GO:0008150,GO:0015205,GO:0015208,GO:0015851,GO:0015854,GO:0016020,GO:0022857,GO:0035344,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072530,GO:0098657,GO:0098710,GO:0098739,GO:1903716,GO:1904823 ko:K06901 ko00000,ko02000 2.A.1.40 Bacteria 2GKYD@201174,4DNIA@85009,COG2252@1,COG2252@2 NA|NA|NA S Permease family MAG.T1.179_01420 134676.ACPL_5559 2.3e-28 134.0 Actinobacteria Bacteria 2IR52@201174,COG1525@1,COG1525@2 NA|NA|NA L Lamin Tail Domain MAG.T1.179_01421 1121272.KB903255_gene5793 2.5e-68 265.8 Micromonosporales pac ko:K07184 ko00000 Bacteria 2I2N7@201174,4DBJV@85008,COG1938@1,COG1938@2 NA|NA|NA S PAC2 family MAG.T1.179_01423 1071400.LBUCD034_0909 4.2e-20 104.4 Lactobacillaceae mscL GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0042592,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066 ko:K03282 ko00000,ko02000 1.A.22.1 Bacteria 1VA14@1239,3F6YZ@33958,4HKIA@91061,COG1970@1,COG1970@2 NA|NA|NA M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell MAG.T1.179_01424 1245475.ANAE01000105_gene2691 5.2e-23 114.8 Streptosporangiales cpaB ko:K02279 ko00000,ko02035,ko02044 Bacteria 2GQJH@201174,4EKC2@85012,COG3745@1,COG3745@2 NA|NA|NA U SAF MAG.T1.179_01425 298653.Franean1_0686 5.8e-18 97.1 Frankiales fmdB Bacteria 2IQHE@201174,4ET9G@85013,COG2331@1,COG2331@2 NA|NA|NA S Regulatory protein, FmdB family MAG.T1.179_01426 465515.Mlut_16430 2.4e-30 139.0 Micrococcaceae fthC 6.3.3.2 ko:K01934 ko00670,ko01100,map00670,map01100 R02301 RC00183 ko00000,ko00001,ko01000 Bacteria 1W9K2@1268,2IKWR@201174,COG0212@1,COG0212@2 NA|NA|NA H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family MAG.T1.179_01427 593907.Celgi_0566 1.2e-94 353.2 Actinobacteria galU GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0003983,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005996,GO:0006011,GO:0006012,GO:0006073,GO:0006139,GO:0006629,GO:0006725,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009056,GO:0009058,GO:0009059,GO:0009103,GO:0009225,GO:0009242,GO:0009244,GO:0009250,GO:0009311,GO:0009312,GO:0009987,GO:0016043,GO:0016051,GO:0016052,GO:0016740,GO:0016772,GO:0016779,GO:0019318,GO:0019320,GO:0019388,GO:0022607,GO:0033499,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043933,GO:0044042,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046377,GO:0046401,GO:0046483,GO:0046872,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051748,GO:0055086,GO:0065003,GO:0070569,GO:0071704,GO:0071840,GO:1900725,GO:1900727,GO:1901135,GO:1901137,GO:1901360,GO:1901575,GO:1901576,GO:1903509 2.7.7.9,5.4.2.8 ko:K00963,ko:K01840 ko00040,ko00051,ko00052,ko00500,ko00520,ko01100,ko01110,ko01130,map00040,map00051,map00052,map00500,map00520,map01100,map01110,map01130 M00114,M00129,M00361,M00362,M00549 R00289,R01818 RC00002,RC00408 ko00000,ko00001,ko00002,ko01000 iECIAI39_1322.ECIAI39_1571,iHN637.CLJU_RS02205,iIT341.HP0646 Bacteria 2I2EW@201174,COG1210@1,COG1210@2 NA|NA|NA M Utp--glucose-1-phosphate uridylyltransferase MAG.T1.179_01428 351607.Acel_0167 2.4e-106 392.5 Frankiales moeA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0018315,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0032324,GO:0034641,GO:0036211,GO:0042040,GO:0042278,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061598,GO:0061599,GO:0070566,GO:0071704,GO:0071944,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 R09735 RC03462 ko00000,ko00001,ko01000 Bacteria 2GJC3@201174,4ERWC@85013,COG0303@1,COG0303@2 NA|NA|NA H MoeA domain protein domain I and II MAG.T1.179_01429 1123322.KB904676_gene3086 3e-60 238.4 Actinobacteria rimJ 2.3.1.128 ko:K03790 ko00000,ko01000,ko03009 Bacteria 2HAFI@201174,COG1670@1,COG1670@2 NA|NA|NA J N-acetyltransferase MAG.T1.179_01433 1112204.GPOL_c41030 6.2e-109 401.4 Gordoniaceae Bacteria 2GKU0@201174,4GD5R@85026,COG1020@1,COG1020@2 NA|NA|NA Q Protein of unknown function (DUF1298) MAG.T1.179_01434 1123321.KB905830_gene755 1.9e-132 479.6 Actinobacteria pmt 2.4.1.109 ko:K00728 ko00514,ko00515,ko01100,map00514,map00515,map01100 R04072,R07620,R11399 RC00005,RC00059,RC00397 ko00000,ko00001,ko01000,ko01003 GT39 Bacteria 2I2H1@201174,COG1928@1,COG1928@2 NA|NA|NA O PFAM glycosyl transferase family 39 MAG.T1.179_01435 100226.SCO3153 6.2e-88 330.9 Actinobacteria rsmI GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.198 ko:K07056 ko00000,ko01000,ko03009 Bacteria 2GJ9Q@201174,COG0313@1,COG0313@2 NA|NA|NA H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA MAG.T1.179_01436 351607.Acel_0175 9.3e-207 726.5 Frankiales metG GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 2GK4S@201174,4ES23@85013,COG0143@1,COG0143@2 NA|NA|NA J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation MAG.T1.179_01437 1122609.AUGT01000017_gene965 3.2e-81 308.5 Propionibacteriales tatD ko:K03424 ko00000,ko01000 Bacteria 2GMJJ@201174,4DPJ5@85009,COG0084@1,COG0084@2 NA|NA|NA L TatD related DNase MAG.T1.179_01438 67257.JODR01000011_gene5452 5.9e-88 330.9 Actinobacteria ksgA GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 ko:K02528 R10716 RC00003,RC03257 ko00000,ko01000,ko03009 Bacteria 2GKBT@201174,COG0030@1,COG0030@2 NA|NA|NA J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits MAG.T1.179_01439 1032480.MLP_27790 7.1e-88 331.3 Propionibacteriales Bacteria 2GP0C@201174,4DS7R@85009,COG1409@1,COG1409@2 NA|NA|NA S Calcineurin-like phosphoesterase MAG.T1.179_01440 446471.Xcel_2724 7.4e-76 290.8 Promicromonosporaceae ispE GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006629,GO:0006720,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0050515,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901576 2.1.1.182,2.7.1.148 ko:K00919,ko:K02528,ko:K16924 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096,M00582 R05634,R10716 RC00002,RC00003,RC01439,RC03257 ko00000,ko00001,ko00002,ko01000,ko02000,ko03009 3.A.1.29 iEC55989_1330.EC55989_1304,iLJ478.TM1383,iYO844.BSU00460 Bacteria 2GKXD@201174,4F3UP@85017,COG1947@1,COG1947@2 NA|NA|NA I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol MAG.T1.179_01441 1304865.JAGF01000001_gene92 7.7e-60 237.7 Actinobacteria manA 5.3.1.8 ko:K01809 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114 R01819 RC00376 ko00000,ko00001,ko00002,ko01000 Bacteria 2I8X4@201174,COG1482@1,COG1482@2 NA|NA|NA G mannose-6-phosphate isomerase MAG.T1.179_01442 1286093.C266_16640 6.8e-60 237.7 Burkholderiaceae mdtB ko:K03296,ko:K07788 ko02020,map02020 M00648 ko00000,ko00001,ko00002,ko02000 2.A.6.2 Bacteria 1K044@119060,1MU48@1224,2VHFI@28216,COG0841@1,COG0841@2 NA|NA|NA V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family MAG.T1.179_01443 1123320.KB889675_gene4004 1.3e-142 513.1 Actinobacteria pepR GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 2GJZ3@201174,COG0612@1,COG0612@2 NA|NA|NA S Belongs to the peptidase M16 family MAG.T1.179_01444 110319.CF8_2787 2.4e-85 322.0 Propionibacteriales dapB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0048037,GO:0050661,GO:0050662,GO:0051287,GO:0055114,GO:0070402,GO:0070404,GO:0071704,GO:0071944,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 iJN678.dapB,iNJ661.Rv2773c,iYO844.BSU22490 Bacteria 2GM2T@201174,4DNG2@85009,COG0289@1,COG0289@2 NA|NA|NA E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate MAG.T1.179_01445 223184.AS25_06030 8.4e-33 146.7 Micrococcaceae Bacteria 1W9QW@1268,2IFHE@201174,COG5010@1,COG5010@2 NA|NA|NA U COG0457 FOG TPR repeat MAG.T1.179_01446 105420.BBPO01000052_gene1853 1.2e-29 136.7 Streptacidiphilus Bacteria 2H3AT@201174,2NGQ3@228398,COG3247@1,COG3247@2 NA|NA|NA S Short repeat of unknown function (DUF308) MAG.T1.179_01447 1123487.KB892846_gene459 1.8e-108 399.1 Proteobacteria supH Bacteria 1Q5HK@1224,COG0561@1,COG0561@2 NA|NA|NA C Hydrolase MAG.T1.179_01448 187303.BN69_3335 1e-55 224.2 Alphaproteobacteria GO:0003674,GO:0003824,GO:0006629,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0044237,GO:0044238,GO:0044255,GO:0071704 ko:K07019 ko00000 Bacteria 1MWV1@1224,2TSMR@28211,COG0429@1,COG0429@2 NA|NA|NA S alpha/beta hydrolase fold MAG.T1.179_01449 66377.JOBH01000004_gene3779 6.5e-48 198.0 Actinobacteria Bacteria 2A4ZY@1,2GMC5@201174,30TN1@2 NA|NA|NA MAG.T1.179_01450 743721.Psesu_0725 9.4e-157 559.7 Xanthomonadales gapA GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0042866,GO:0043436,GO:0043891,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 iAPECO1_1312.APECO1_847,iPC815.YPO2157,iUTI89_1310.UTI89_C1975,ic_1306.c2184 Bacteria 1MU93@1224,1RMBM@1236,1X34S@135614,COG0057@1,COG0057@2 NA|NA|NA G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family MAG.T1.179_01451 1449353.JQMQ01000005_gene485 2.6e-11 74.7 Actinobacteria Bacteria 2BNAP@1,2GTB3@201174,32GYA@2 NA|NA|NA MAG.T1.179_01452 1048339.KB913029_gene3575 1.9e-95 355.5 Actinobacteria thyX 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 R06613 RC00022,RC00332 ko00000,ko00001,ko01000 Bacteria 2HCNJ@201174,COG1351@1,COG1351@2 NA|NA|NA F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant MAG.T1.179_01453 1193181.BN10_1320023 7.5e-57 227.3 Actinobacteria 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 R00578 RC00010 ko00000,ko00001,ko01000,ko01002 Bacteria 2IAKK@201174,COG1478@1,COG1478@2 NA|NA|NA S F420-0:Gamma-glutamyl ligase MAG.T1.179_01454 68570.DC74_5827 1.2e-107 396.4 Actinobacteria dapA 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ34@201174,COG0329@1,COG0329@2 NA|NA|NA E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) MAG.T1.179_01455 1095767.CAHD01000224_gene2103 2.8e-238 831.2 Cellulomonadaceae rnj GO:0003674,GO:0005488,GO:0005515,GO:0042802 ko:K12574 ko03018,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 2GIW7@201174,4F0MZ@85016,COG0595@1,COG0595@2 NA|NA|NA S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay MAG.T1.179_01456 351607.Acel_1501 2.6e-252 878.6 Frankiales ftsK GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 ko:K03466 ko00000,ko03036 3.A.12 Bacteria 2GK3T@201174,4ERQD@85013,COG1674@1,COG1674@2 NA|NA|NA D DNA translocase ftsK MAG.T1.179_01457 1120950.KB892756_gene6657 3.5e-155 555.1 Propionibacteriales rimO GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016782,GO:0018193,GO:0018197,GO:0018198,GO:0018339,GO:0019538,GO:0035596,GO:0035599,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901564 2.8.4.4 ko:K14441 R10652 RC00003,RC03217 ko00000,ko01000,ko03009 Bacteria 2GKRI@201174,4DNHY@85009,COG0621@1,COG0621@2 NA|NA|NA J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 MAG.T1.179_01458 471852.Tcur_3305 9e-52 210.3 Streptosporangiales pgsA GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 Bacteria 2GK5D@201174,4EIN9@85012,COG0558@1,COG0558@2 NA|NA|NA I CDP-alcohol phosphatidyltransferase MAG.T1.179_01459 1122239.AULS01000007_gene453 4.3e-25 121.3 Microbacteriaceae cinA 3.5.1.42 ko:K03742,ko:K03743 ko00760,map00760 R02322 RC00100 ko00000,ko00001,ko01000 Bacteria 2IQ8T@201174,4FPN9@85023,COG1546@1,COG1546@2 NA|NA|NA S Competence-damaged protein MAG.T1.179_01460 1476876.JOJO01000017_gene1354 2.8e-23 114.4 Actinobacteria clgR GO:0002682,GO:0002683,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006109,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009268,GO:0009408,GO:0009605,GO:0009607,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009894,GO:0009987,GO:0010447,GO:0010468,GO:0010556,GO:0010557,GO:0010565,GO:0010604,GO:0010628,GO:0010675,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0022611,GO:0030162,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031347,GO:0031348,GO:0032268,GO:0032502,GO:0033554,GO:0035821,GO:0040007,GO:0042176,GO:0043207,GO:0043565,GO:0043620,GO:0044003,GO:0044110,GO:0044111,GO:0044114,GO:0044115,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044413,GO:0044414,GO:0044419,GO:0045088,GO:0045824,GO:0045893,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048583,GO:0048585,GO:0050776,GO:0050777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051252,GO:0051254,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051817,GO:0051832,GO:0051833,GO:0052031,GO:0052037,GO:0052167,GO:0052170,GO:0052173,GO:0052200,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0060255,GO:0061136,GO:0062012,GO:0065007,GO:0075136,GO:0080090,GO:0080134,GO:0085016,GO:0090062,GO:0097159,GO:1901363,GO:1902680,GO:1902882,GO:1903050,GO:1903362,GO:1903506,GO:1903508,GO:2000112,GO:2001141 Bacteria 2GR3F@201174,COG1396@1,COG1396@2 NA|NA|NA K transcriptional MAG.T1.179_01461 1054860.KB913030_gene4976 0.0 1554.3 Actinobacteria lhr GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 ko:K03724 ko00000,ko01000,ko03400 Bacteria 2GJG3@201174,COG1201@1,COG1201@2 NA|NA|NA L dead DEAH box helicase MAG.T1.179_01462 1380354.JIAN01000007_gene107 1.7e-161 575.5 Cellulomonadaceae recA GO:0000150,GO:0000166,GO:0000287,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009650,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0031668,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042148,GO:0042221,GO:0042623,GO:0043142,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 ko:K03553 ko03440,map03440 M00729 ko00000,ko00001,ko00002,ko03400 Bacteria 2GJ4P@201174,4F0Z7@85016,COG0468@1,COG0468@2 NA|NA|NA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage MAG.T1.179_01463 1121272.KB903272_gene431 2.1e-33 149.1 Micromonosporales recX GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03565 ko00000,ko03400 Bacteria 2GMRF@201174,4DD5X@85008,COG2137@1,COG2137@2 NA|NA|NA S Modulates RecA activity MAG.T1.179_01464 471852.Tcur_3285 1.5e-195 689.1 Streptosporangiales miaB 2.8.4.3 ko:K06168 R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 Bacteria 2GJEV@201174,4EFYX@85012,COG0621@1,COG0621@2 NA|NA|NA J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine MAG.T1.179_01465 66377.JOBH01000011_gene2229 2.8e-22 112.5 Actinobacteria 2.8.4.3 ko:K06168 R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 Bacteria 2GN3T@201174,COG3885@1,COG3885@2 NA|NA|NA S ferrous iron binding MAG.T1.179_01466 266940.Krad_1500 2e-76 292.7 Actinobacteria miaA GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006417,GO:0006725,GO:0006807,GO:0006950,GO:0008033,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009451,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016070,GO:0016740,GO:0016765,GO:0019222,GO:0031323,GO:0031326,GO:0032268,GO:0033554,GO:0034248,GO:0034470,GO:0034605,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0043555,GO:0044237,GO:0044238,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0051716,GO:0052381,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1990497,GO:2000112,GO:2000765 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 Bacteria 2GKFT@201174,COG0324@1,COG0324@2 NA|NA|NA J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) MAG.T1.179_01467 1449346.JQMO01000003_gene3598 1.6e-72 279.6 Kitasatospora dapF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 iIT341.HP0566,iLJ478.TM1522 Bacteria 2GKUD@201174,2M07M@2063,COG0253@1,COG0253@2 NA|NA|NA E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan MAG.T1.179_01468 1048339.KB913029_gene4763 4.8e-172 610.9 Frankiales hflX GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 ko:K03665 ko00000,ko03009 Bacteria 2GK55@201174,4ERJ5@85013,COG2262@1,COG2262@2 NA|NA|NA S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis MAG.T1.179_01469 471857.Svir_29270 3.4e-163 582.0 Pseudonocardiales dinG GO:0003674,GO:0003824,GO:0004386,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008026,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0042575,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0045004,GO:0045005,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7,3.6.4.12 ko:K02342,ko:K03722 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 2GKT8@201174,4E0JP@85010,COG1199@1,COG1199@2 NA|NA|NA KL helicase MAG.T1.179_01470 1169154.KB897780_gene2333 6e-122 444.5 Actinobacteria Bacteria 2GKEK@201174,COG4320@1,COG4320@2 NA|NA|NA K protein conserved in bacteria MAG.T1.179_01471 1120950.KB892707_gene4592 5.9e-83 313.9 Propionibacteriales lexA GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0033554,GO:0042221,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045934,GO:0046677,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 3.4.21.88 ko:K01356 M00729 ko00000,ko00002,ko01000,ko01002,ko03400 Bacteria 2GMBN@201174,4DNCQ@85009,COG1974@1,COG1974@2 NA|NA|NA K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair MAG.T1.179_01472 1150399.AQYK01000002_gene2473 7.4e-11 73.6 Microbacteriaceae Bacteria 2GWI9@201174,4FQ73@85023,COG1388@1,COG1388@2 NA|NA|NA M Lysin motif MAG.T1.179_01473 469371.Tbis_2426 5.1e-55 220.7 Pseudonocardiales nrdR GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 ko:K07738 ko00000,ko03000 Bacteria 2IHU9@201174,4E2M8@85010,COG1327@1,COG1327@2 NA|NA|NA K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes MAG.T1.179_01474 1120934.KB894440_gene5692 0.0 1456.4 Pseudonocardiales nrdJ 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 Bacteria 2GKX9@201174,4DY0W@85010,COG0209@1,COG0209@2 NA|NA|NA F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen MAG.T1.179_01475 1122939.ATUD01000001_gene368 1.4e-74 287.0 Actinobacteria Bacteria 2IKC2@201174,COG3437@1,COG3437@2 NA|NA|NA T cheY-homologous receiver domain MAG.T1.179_01476 1049564.TevJSym_af00930 6.4e-80 304.7 unclassified Gammaproteobacteria phcR ko:K19622 ko02020,map02020 ko00000,ko00001,ko02022 Bacteria 1J6BK@118884,1RCW6@1224,1S3XV@1236,COG1639@1,COG1639@2,COG2204@1,COG2204@2 NA|NA|NA T HDOD domain MAG.T1.179_01477 1121459.AQXE01000005_gene1544 4.8e-105 388.7 Desulfovibrionales Bacteria 1RCM9@1224,2MHHP@213115,2WKHK@28221,42PGC@68525,COG4191@1,COG4191@2 NA|NA|NA T Histidine kinase-like ATPases MAG.T1.179_01479 595494.Tola_0290 2.2e-60 238.4 Gammaproteobacteria rpiB 5.3.1.6 ko:K01808 ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01056,R09030 RC00376,RC00434 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1604 Bacteria 1RHBF@1224,1SAUU@1236,COG0698@1,COG0698@2 NA|NA|NA G Ribose 5-phosphate isomerase MAG.T1.179_01480 1112204.GPOL_c02910 2.3e-40 171.8 Gordoniaceae yccF Bacteria 2IKS5@201174,4GE90@85026,COG3304@1,COG3304@2 NA|NA|NA S Inner membrane component domain MAG.T1.179_01481 398580.Dshi_3076 2.2e-09 68.9 Alphaproteobacteria greA GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006354,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0030312,GO:0031323,GO:0031326,GO:0032774,GO:0032784,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 ko:K03624 ko00000,ko03021 Bacteria 1RCXW@1224,2U5JU@28211,COG0782@1,COG0782@2 NA|NA|NA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides MAG.T1.179_01482 1211815.CBYP010000071_gene1316 2.1e-21 110.2 Frankiales Bacteria 2AR9G@1,2GN9V@201174,31GJC@2,4EWX7@85013 NA|NA|NA S Domain of unknown function (DUF4192) MAG.T1.179_01483 1306174.JODP01000013_gene7801 5.7e-215 753.4 Actinobacteria metY 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 iNJ661.Rv3340 Bacteria 2I2EB@201174,COG2873@1,COG2873@2 NA|NA|NA E O-acetylhomoserine MAG.T1.179_01484 196162.Noca_2967 1.6e-27 129.0 Propionibacteriales Bacteria 2IR3G@201174,4DRRV@85009,COG0589@1,COG0589@2 NA|NA|NA T Universal stress protein family MAG.T1.179_01485 680646.RMDY18_07340 7.5e-85 320.9 Bacteria Bacteria 294D0@1,2ZRSZ@2 NA|NA|NA MAG.T1.179_01486 1120950.KB892759_gene6261 6.3e-67 261.2 Propionibacteriales lytR2 Bacteria 2GJJJ@201174,4DPY2@85009,COG1316@1,COG1316@2 NA|NA|NA K Cell envelope-related transcriptional attenuator domain MAG.T1.179_01487 710685.MycrhN_3684 1.7e-33 149.4 Mycobacteriaceae Bacteria 232CS@1762,28JRZ@1,2H9EF@201174,2Z9HI@2 NA|NA|NA S Domain of unknown function (DUF4126) MAG.T1.179_01488 653045.Strvi_0527 7e-21 106.7 Actinobacteria purS 6.3.2.6,6.3.5.3 ko:K01923,ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463,R04591 RC00010,RC00064,RC00162,RC01160 ko00000,ko00001,ko00002,ko01000 iYO844.BSU06460 Bacteria 2GQV4@201174,COG1828@1,COG1828@2 NA|NA|NA F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL MAG.T1.179_01489 452652.KSE_38460 5.3e-98 364.0 Kitasatospora purQ GO:0003674,GO:0003824,GO:0004642,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 Bacteria 2GMJY@201174,2M20R@2063,COG0047@1,COG0047@2 NA|NA|NA F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL MAG.T1.179_01490 68570.DC74_4016 0.0 1122.1 Actinobacteria purL GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKG6@201174,COG0046@1,COG0046@2 NA|NA|NA F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL MAG.T1.179_01491 1120948.KB903217_gene1248 9.4e-48 196.8 Pseudonocardiales Bacteria 2II0D@201174,4E47X@85010,COG4430@1,COG4430@2 NA|NA|NA S Bacteriocin-protection, YdeI or OmpD-Associated MAG.T1.179_01492 1122602.ATXP01000017_gene2260 3.8e-26 124.4 Micrococcaceae Bacteria 1W9SC@1268,2IQBF@201174,COG3255@1,COG3255@2 NA|NA|NA I Sterol carrier protein MAG.T1.179_01493 479432.Sros_8991 1.9e-203 715.3 Streptosporangiales purF GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009507,GO:0009536,GO:0040007,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 Bacteria 2GK6I@201174,4EGDA@85012,COG0034@1,COG0034@2 NA|NA|NA F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine MAG.T1.179_01494 1288083.AUKR01000017_gene2494 1.1e-129 469.9 Actinobacteria purM GO:0003674,GO:0003824,GO:0004641,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.1,6.3.4.13 ko:K01933,ko:K11788 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144,R04208 RC00090,RC00166,RC01100 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1844,iECSF_1327.ECSF_2340 Bacteria 2GJNY@201174,COG0150@1,COG0150@2 NA|NA|NA F Phosphoribosylformylglycinamidine cyclo-ligase MAG.T1.179_01495 1121272.KB903261_gene6014 2e-08 64.7 Micromonosporales Bacteria 2EGRW@1,2IQF3@201174,33AI2@2,4DFQ7@85008 NA|NA|NA S Protein of unknown function (DUF3073) MAG.T1.179_01496 479433.Caci_0301 2.8e-21 107.5 Actinobacteria bldC Bacteria 2GQJ9@201174,COG2452@1,COG2452@2 NA|NA|NA L TIGRFAM DNA binding domain protein, excisionase family MAG.T1.179_01497 1440053.JOEI01000024_gene1194 4e-99 368.6 Actinobacteria dinF GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03327 ko00000,ko02000 2.A.66.1 Bacteria 2GJE3@201174,COG0534@1,COG0534@2 NA|NA|NA V MATE efflux family protein MAG.T1.179_01498 1033730.CAHG01000006_gene1155 6.4e-19 99.8 Propionibacteriales ko:K07213 ko04978,map04978 ko00000,ko00001 Bacteria 2GQK5@201174,4DSND@85009,COG2608@1,COG2608@2 NA|NA|NA P Heavy-metal-associated domain MAG.T1.179_01499 1120949.KB903317_gene1657 2.7e-54 219.9 Micromonosporales ko:K14645 ko02024,map02024 ko00000,ko00001,ko01000,ko01002,ko03110 Bacteria 2GIRE@201174,4DAEM@85008,COG1404@1,COG1404@2 NA|NA|NA O Belongs to the peptidase S8 family MAG.T1.179_01500 208439.AJAP_30840 1.2e-28 134.4 Pseudonocardiales Bacteria 2H2HE@201174,4E9WQ@85010,COG2199@1,COG3706@2 NA|NA|NA T diguanylate cyclase MAG.T1.179_01501 1306174.JODP01000015_gene3952 1.7e-149 536.2 Actinobacteria Bacteria 2IBIG@201174,COG0477@1,COG0477@2 NA|NA|NA EGP Major facilitator superfamily MAG.T1.179_01503 69042.WH5701_11009 5e-19 102.1 Synechococcus Bacteria 1GQGS@1117,1H229@1129,COG0596@1,COG0596@2 NA|NA|NA S hydrolases or acyltransferases (alpha beta hydrolase superfamily) MAG.T1.179_01505 1122611.KB903941_gene2200 3.3e-15 87.8 Actinobacteria Bacteria 2IQ8I@201174,COG1695@1,COG1695@2 NA|NA|NA K Transcriptional regulator PadR family protein MAG.T1.179_01506 358823.DF19_29430 1.5e-28 132.1 Actinobacteria Bacteria 2IQ8I@201174,COG1695@1,COG1695@2 NA|NA|NA K Transcriptional regulator PadR family protein MAG.T1.179_01510 1120950.KB892764_gene5614 3.8e-156 558.1 Propionibacteriales tgs3 GO:0000302,GO:0001666,GO:0003674,GO:0003824,GO:0004144,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006629,GO:0006638,GO:0006639,GO:0006641,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0009058,GO:0009628,GO:0009987,GO:0010035,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0019432,GO:0030312,GO:0036293,GO:0040007,GO:0042221,GO:0042493,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0044464,GO:0045017,GO:0046460,GO:0046463,GO:0046486,GO:0047196,GO:0050896,GO:0051704,GO:0070482,GO:0071704,GO:0071731,GO:0071944,GO:0097366,GO:1901576,GO:1901698,GO:1901700 2.3.1.20 ko:K00635 ko00561,ko01100,map00561,map01100 M00089 R02251 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 Bacteria 2HEFF@201174,4DN7F@85009,COG1020@1,COG1020@2 NA|NA|NA Q Belongs to the long-chain O-acyltransferase family MAG.T1.179_01511 479433.Caci_7582 6.8e-75 287.7 Actinobacteria ko:K07001 ko00000 Bacteria 2IB0F@201174,COG1752@1,COG1752@2 NA|NA|NA S esterase of the alpha-beta hydrolase superfamily MAG.T1.179_01513 1380370.JIBA01000014_gene2099 6.5e-18 97.4 Intrasporangiaceae Bacteria 2GS2W@201174,4FGK2@85021,COG3832@1,COG3832@2 NA|NA|NA S Protein of unknown function (DUF2505) MAG.T1.179_01514 1385518.N798_16970 4.7e-21 107.8 Intrasporangiaceae Bacteria 2GS2W@201174,4FGK2@85021,COG3832@1,COG3832@2 NA|NA|NA S Protein of unknown function (DUF2505) MAG.T1.179_01515 1394178.AWOO02000005_gene3638 0.0 1547.3 Streptosporangiales gdhB GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016638,GO:0016639,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 R00243 RC00006,RC02799 ko00000,ko00001,ko01000 Bacteria 2GK0C@201174,4EGYX@85012,COG2902@1,COG2902@2 NA|NA|NA E Bacterial NAD-glutamate dehydrogenase MAG.T1.179_01516 1172188.KB911820_gene2155 6.7e-12 77.4 Actinobacteria Bacteria 2B2RZ@1,2GVDD@201174,31VC7@2 NA|NA|NA MAG.T1.179_01517 1907.SGLAU_03150 8.1e-30 139.4 Actinobacteria 3.4.24.84 ko:K06013 ko00900,ko01130,map00900,map01130 R09845 RC00141 ko00000,ko00001,ko01000,ko01002,ko04147 Bacteria 2GZ0N@201174,COG0501@1,COG0501@2 NA|NA|NA O Peptidase family M48 MAG.T1.179_01518 526225.Gobs_1233 4.7e-154 550.8 Frankiales prfB GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02836 ko00000,ko03012 Bacteria 2GJ0F@201174,4ERJ3@85013,COG1186@1,COG1186@2 NA|NA|NA J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA MAG.T1.179_01519 1123320.KB889677_gene2736 6.1e-99 367.1 Actinobacteria ftsE GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019897,GO:0019898,GO:0030145,GO:0030554,GO:0031234,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363 ko:K09811,ko:K09812 ko02010,map02010 M00256 ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 Bacteria 2GJE1@201174,COG2884@1,COG2884@2 NA|NA|NA D cell division ATP-binding protein FtsE MAG.T1.179_01520 1048339.KB913029_gene5048 5.2e-82 311.2 Frankiales ftsX GO:0000910,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0007154,GO:0007165,GO:0007166,GO:0008150,GO:0008356,GO:0009274,GO:0009276,GO:0009966,GO:0009987,GO:0010033,GO:0010646,GO:0016020,GO:0016021,GO:0016043,GO:0019221,GO:0022402,GO:0022603,GO:0022607,GO:0023051,GO:0023052,GO:0030312,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0032153,GO:0032506,GO:0034097,GO:0040007,GO:0042173,GO:0042221,GO:0043937,GO:0043938,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051094,GO:0051301,GO:0051716,GO:0065007,GO:0070098,GO:0070297,GO:0070887,GO:0071310,GO:0071345,GO:0071840,GO:0071944,GO:0090529,GO:1902531 ko:K09811,ko:K09812 ko02010,map02010 M00256 ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 Bacteria 2GJMA@201174,4ESQ7@85013,COG2177@1,COG2177@2 NA|NA|NA D Part of the ABC transporter FtsEX involved in cellular division MAG.T1.179_01521 768706.Desor_5488 2e-31 143.7 Peptococcaceae ko:K21471,ko:K21472 ko00000,ko01000,ko01002,ko01011 Bacteria 1VAC5@1239,25E3G@186801,267BP@186807,COG0739@1,COG0739@2,COG3883@1,COG3883@2 NA|NA|NA M PFAM Peptidase family M23 MAG.T1.179_01522 330084.JNYZ01000010_gene6967 2.6e-56 224.9 Pseudonocardiales smpB GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0070930,GO:0071704,GO:0097159,GO:1901363,GO:1901564 ko:K03664 ko00000 Bacteria 2GJX1@201174,4E2R0@85010,COG0691@1,COG0691@2 NA|NA|NA O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA MAG.T1.179_01524 397278.JOJN01000017_gene2520 2.8e-21 108.6 Propionibacteriales Bacteria 2EBIV@1,2IHZS@201174,335JA@2,4DRF2@85009 NA|NA|NA MAG.T1.179_01525 1122994.AUFR01000024_gene25 4.9e-146 524.6 Propionibacteriales yuaG ko:K07192 ko04910,map04910 ko00000,ko00001,ko03036,ko04131,ko04147 Bacteria 2GK9I@201174,4DNKB@85009,COG2268@1,COG2268@2 NA|NA|NA S Flotillin MAG.T1.179_01526 2045.KR76_08315 7e-37 161.4 Propionibacteriales ko:K13573 ko00000,ko03051 Bacteria 2IMC4@201174,4DRG9@85009,COG2378@1,COG2378@2 NA|NA|NA K WYL domain MAG.T1.179_01527 2045.KR76_08310 3.1e-26 125.9 Propionibacteriales Bacteria 2FJ4K@1,2GVYD@201174,34AUV@2,4DS69@85009 NA|NA|NA S WYL domain MAG.T1.179_01528 33876.JNXY01000028_gene3328 6.2e-07 62.4 Micromonosporales Bacteria 2BNCX@1,2H4ZP@201174,32H0K@2,4DIXP@85008 NA|NA|NA MAG.T1.179_01530 1394178.AWOO02000082_gene2172 1.9e-18 101.7 Streptosporangiales Bacteria 2GJAR@201174,4EG63@85012,COG2909@1,COG2909@2 NA|NA|NA K AAA ATPase domain MAG.T1.179_01531 1038860.AXAP01000018_gene3103 5.2e-40 170.6 Bradyrhizobiaceae Bacteria 1RGXV@1224,2U9EH@28211,3JY58@41294,COG5579@1,COG5579@2 NA|NA|NA S Protein of unknown function (DUF1810) MAG.T1.179_01532 1122130.AUHN01000005_gene2450 2.7e-23 116.3 Bacteria 3.2.1.14 ko:K01183 ko00520,ko01100,map00520,map01100 R01206,R02334 RC00467 ko00000,ko00001,ko01000 GH18 Bacteria COG2374@1,COG2374@2,COG4733@1,COG4733@2 NA|NA|NA S cellulase activity MAG.T1.179_01535 1504319.GM45_4930 8.5e-45 186.0 unclassified Actinobacteria (class) sigA ko:K03086 ko00000,ko03021 Bacteria 2GK3Z@201174,3UWCE@52018,COG0568@1,COG0568@2 NA|NA|NA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released MAG.T1.179_01536 1500257.JQNM01000020_gene2569 1.5e-43 182.6 Rhizobiaceae Bacteria 1N7IY@1224,2U993@28211,4BFSP@82115,COG3865@1,COG3865@2 NA|NA|NA S 3-demethylubiquinone-9 3-methyltransferase MAG.T1.179_01537 998088.B565_0889 2.2e-26 125.6 Gammaproteobacteria Bacteria 1RB8R@1224,1S1A6@1236,COG1051@1,COG1051@2 NA|NA|NA F COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes MAG.T1.179_01538 1122130.AUHN01000009_gene584 1e-140 507.3 Actinobacteria bglF ko:K02755,ko:K02756,ko:K02757 ko02060,map02060 M00271 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.2.11,4.A.1.2.2,4.A.1.2.5,4.A.1.2.6 Bacteria 2GK6B@201174,COG1263@1,COG1263@2,COG1264@1,COG1264@2,COG2190@1,COG2190@2 NA|NA|NA G Pts system MAG.T1.179_01539 1178540.BA70_17750 1.4e-49 203.4 Bacillus ko:K02538,ko:K03488 ko00000,ko03000 Bacteria 1TQJJ@1239,1ZMHP@1386,4HBB3@91061,COG3711@1,COG3711@2 NA|NA|NA K CAT RNA binding domain MAG.T1.179_01540 1304865.JAGF01000001_gene2261 3e-233 814.3 Actinobacteria bglH 3.2.1.86 ko:K01223 ko00010,ko00500,map00010,map00500 R00839,R05133,R05134 RC00049,RC00171,RC00714 ko00000,ko00001,ko01000 GT1 Bacteria 2GJAF@201174,COG2723@1,COG2723@2 NA|NA|NA G Belongs to the glycosyl hydrolase 1 family MAG.T1.179_01541 1304865.JAGF01000001_gene2260 5.5e-227 793.9 Actinobacteria bglF ko:K02755,ko:K02756,ko:K02757 ko02060,map02060 M00271 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.2.11,4.A.1.2.2,4.A.1.2.5,4.A.1.2.6 Bacteria 2GK6B@201174,COG1263@1,COG1263@2,COG1264@1,COG1264@2,COG2190@1,COG2190@2 NA|NA|NA G Pts system MAG.T1.179_01542 446471.Xcel_0116 3.7e-31 141.7 Promicromonosporaceae 5.4.2.12 ko:K15634,ko:K15640 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 Bacteria 2GK2I@201174,4F5AK@85017,COG0406@1,COG0406@2 NA|NA|NA G Phosphoglycerate mutase family MAG.T1.179_01543 1348663.KCH_12620 4.5e-189 667.5 Kitasatospora guaC GO:0003674,GO:0003824,GO:0003920,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0015949,GO:0015950,GO:0015951,GO:0016020,GO:0016491,GO:0016651,GO:0016657,GO:0019637,GO:0019693,GO:0034641,GO:0042802,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.1.1.205,1.7.1.7 ko:K00088,ko:K00364 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R01134,R08240 RC00143,RC00457,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 iEC042_1314.EC042_0103,iECIAI39_1322.ECIAI39_0105,iECUMN_1333.ECUMN_0102 Bacteria 2GNDC@201174,2M0KH@2063,COG0516@1,COG0516@2,COG0517@1,COG0517@2 NA|NA|NA F IMP dehydrogenase / GMP reductase domain MAG.T1.179_01544 882086.SacxiDRAFT_0618 0.0 1188.7 Pseudonocardiales hrpA GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0006139,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 ko:K03578 ko00000,ko01000 Bacteria 2GIWX@201174,4E02F@85010,COG1643@1,COG1643@2 NA|NA|NA L TIGRFAM ATP-dependent helicase HrpA MAG.T1.179_01546 37919.EP51_31660 4.2e-30 137.9 Nocardiaceae yqgC ko:K09793 ko00000 Bacteria 2IQDE@201174,4G1BR@85025,COG2839@1,COG2839@2 NA|NA|NA S Protein of unknown function (DUF456) MAG.T1.179_01547 446468.Ndas_3308 6.3e-10 69.7 Streptosporangiales Bacteria 2E39Y@1,2GQJA@201174,32Y9G@2,4EKEQ@85012 NA|NA|NA MAG.T1.179_01548 469371.Tbis_2394 2e-273 948.3 Pseudonocardiales gyrB2 5.99.1.3 ko:K02470 ko00000,ko01000,ko03032,ko03400 Bacteria 2GM1E@201174,4DZQK@85010,COG0187@1,COG0187@2 NA|NA|NA L PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MAG.T1.179_01549 479432.Sros_7083 7.4e-52 210.3 Streptosporangiales cah 4.2.1.1 ko:K01673 ko00910,map00910 R00132,R10092 RC02807 ko00000,ko00001,ko01000 Bacteria 2GM1M@201174,4EIY6@85012,COG0288@1,COG0288@2 NA|NA|NA P Reversible hydration of carbon dioxide MAG.T1.179_01550 66377.JOBH01000015_gene4135 9.9e-111 406.8 Actinobacteria yumC GO:0008150,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0042221,GO:0050896,GO:0051716,GO:0070887,GO:0071241,GO:0071248,GO:0071281 1.18.1.2,1.19.1.1 ko:K21567 ko00000,ko01000 iYO844.BSU32110 Bacteria 2GJ1Z@201174,COG0492@1,COG0492@2 NA|NA|NA C Ferredoxin-NADP reductase MAG.T1.179_01551 561175.KB894100_gene4794 9.3e-44 184.1 Streptosporangiales ko:K07058 ko00000 Bacteria 2GM6P@201174,4EIBQ@85012,COG1295@1,COG1295@2 NA|NA|NA S Virulence factor BrkB MAG.T1.179_01552 1033730.CAHG01000012_gene2363 3.7e-11 73.2 Propionibacteriales Bacteria 2EGJK@1,2GX71@201174,33ABR@2,4DSKZ@85009 NA|NA|NA MAG.T1.179_01554 1077972.ARGLB_050_00040 5e-132 478.4 Micrococcaceae ko:K06883 ko00000 Bacteria 1W8MB@1268,2GJX9@201174,COG0699@1,COG0699@2 NA|NA|NA S Dynamin family MAG.T1.179_01555 1713.JOFV01000005_gene2394 6.1e-89 335.1 Cellulomonadaceae PPA1638 ko:K06883 ko00000 Bacteria 2GM68@201174,4F0FD@85016,COG0699@1,COG0699@2 NA|NA|NA S 50S ribosome-binding GTPase MAG.T1.179_01556 1536773.R70331_22715 2.3e-65 256.1 Paenibacillaceae 1.6.5.5 ko:K00344 ko00000,ko01000 Bacteria 1TZGF@1239,26UA2@186822,4HEDQ@91061,COG0604@1,COG0604@2 NA|NA|NA C Zinc-binding alcohol dehydrogenase MAG.T1.179_01557 512565.AMIS_37850 1.4e-40 172.6 Micromonosporales hsp20 ko:K13993 ko04141,map04141 ko00000,ko00001,ko03110 Bacteria 2IHVJ@201174,4DE8J@85008,COG0071@1,COG0071@2 NA|NA|NA O Belongs to the small heat shock protein (HSP20) family MAG.T1.179_01559 935839.JAGJ01000016_gene2363 2e-38 165.6 Promicromonosporaceae Bacteria 2IM6D@201174,4F4NF@85017,COG4119@1,COG4119@2 NA|NA|NA L NUDIX domain MAG.T1.179_01560 1463825.JNXC01000017_gene6952 1.5e-220 772.7 Pseudonocardiales Bacteria 2GIUI@201174,4DXAD@85010,COG3408@1,COG3408@2 NA|NA|NA G Glycogen debranching enzyme MAG.T1.179_01561 1463825.JNXC01000017_gene6951 1.3e-92 346.7 Pseudonocardiales ko:K00713,ko:K06338 ko00000,ko01000,ko01003,ko01005 Bacteria 2I005@201174,4DXXN@85010,COG0438@1,COG0438@2 NA|NA|NA M PFAM Glycosyl transferases group 1 MAG.T1.179_01562 590998.Celf_3039 1.3e-220 773.5 Actinobacteria Bacteria 2GN7G@201174,COG3291@1,COG3291@2 NA|NA|NA P PFAM PKD domain containing protein MAG.T1.179_01566 1172180.KB911785_gene337 2e-122 445.7 Actinobacteria pabB 2.6.1.85,4.1.3.27,4.1.3.38 ko:K01665,ko:K03342,ko:K13503,ko:K13950 ko00400,ko00790,ko01100,ko01110,ko01130,ko01230,map00400,map00790,map01100,map01110,map01130,map01230 M00023 R00985,R00986,R01716,R05553 RC00010,RC01418,RC01843,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 2GN7D@201174,COG0147@1,COG0147@2 NA|NA|NA EH PFAM chorismate MAG.T1.179_01567 1003195.SCAT_5281 5.2e-71 274.6 Actinobacteria 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 2GN5Z@201174,COG0115@1,COG0115@2 NA|NA|NA EH Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase MAG.T1.179_01568 67257.JODR01000017_gene4448 2.5e-26 125.2 Actinobacteria ssgB GO:0000003,GO:0000910,GO:0005575,GO:0005618,GO:0005623,GO:0007049,GO:0008150,GO:0009653,GO:0009987,GO:0010564,GO:0010927,GO:0016043,GO:0019954,GO:0022402,GO:0022607,GO:0030154,GO:0030312,GO:0030428,GO:0030435,GO:0030436,GO:0030447,GO:0030448,GO:0031160,GO:0032465,GO:0032467,GO:0032502,GO:0032506,GO:0032989,GO:0032991,GO:0040007,GO:0042244,GO:0042546,GO:0043934,GO:0043936,GO:0044085,GO:0044457,GO:0044464,GO:0045229,GO:0045787,GO:0048518,GO:0048522,GO:0048646,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0051301,GO:0051302,GO:0051726,GO:0051781,GO:0065007,GO:0070590,GO:0070726,GO:0071554,GO:0071555,GO:0071840,GO:0071944,GO:0090068,GO:0090529,GO:1903664,GO:1903666,GO:1990586,GO:2000241,GO:2000243,GO:2000244,GO:2000246 Bacteria 2IFE3@201174,32RFA@2,arCOG03175@1 NA|NA|NA S sporulation resulting in formation of a cellular spore MAG.T1.179_01569 471852.Tcur_2049 8.3e-23 114.0 Streptosporangiales Bacteria 2EQY7@1,2I34U@201174,33IHV@2,4ER5N@85012 NA|NA|NA S Putative transmembrane protein (PGPGW) MAG.T1.179_01572 1386089.N865_13575 9.6e-39 166.8 Intrasporangiaceae Bacteria 2EH65@1,2I75W@201174,33AY1@2,4FH3V@85021 NA|NA|NA S Domain of unknown function (DUF1876) MAG.T1.179_01573 196162.Noca_1668 8.8e-271 939.5 Actinobacteria GO:0000041,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0006826,GO:0008150,GO:0008152,GO:0008823,GO:0015677,GO:0015682,GO:0016020,GO:0016021,GO:0016491,GO:0016722,GO:0016723,GO:0030001,GO:0031224,GO:0031226,GO:0033216,GO:0034220,GO:0034755,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0052851,GO:0055085,GO:0055114,GO:0071944,GO:0072512,GO:0097286,GO:0098655,GO:0098657,GO:0098659,GO:0098660,GO:0098662,GO:0098706,GO:0098711,GO:0098739,GO:0099587 1.2.1.80 ko:K14330 ko00000,ko01000 Bacteria 2IEVX@201174,COG5322@1,COG5322@2 NA|NA|NA S oxidoreductase activity MAG.T1.179_01574 1108045.GORHZ_135_00210 1.1e-121 443.4 Gordoniaceae acrA1_1 Bacteria 2I2PV@201174,4GAW1@85026,COG3320@1,COG3320@2 NA|NA|NA M Male sterility protein MAG.T1.179_01575 1122138.AQUZ01000001_gene1498 6.2e-277 959.9 Propionibacteriales thrS GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 2GKTC@201174,4DN38@85009,COG0441@1,COG0441@2 NA|NA|NA J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) MAG.T1.179_01576 1120949.KB903314_gene339 1.1e-150 539.7 Actinobacteria ybdK GO:0003674,GO:0003824,GO:0016874,GO:0016879 ko:K06048 ko00000,ko01000 Bacteria 2GKAA@201174,COG2170@1,COG2170@2 NA|NA|NA S ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity MAG.T1.179_01577 1077972.ARGLB_080_00570 1.3e-07 64.7 Micrococcaceae Bacteria 1W96H@1268,2GXWA@201174,COG4932@1,COG4932@2 NA|NA|NA M Belongs to the peptidase S8 family MAG.T1.179_01578 1306174.JODP01000013_gene7557 1.7e-50 205.7 Actinobacteria hit GO:0003674,GO:0003824,GO:0003877,GO:0004551,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008796,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009987,GO:0015959,GO:0015961,GO:0015965,GO:0015967,GO:0016020,GO:0016462,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0070566,GO:0071704,GO:0071944,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 2.7.7.53 ko:K19710 ko00230,map00230 R00126,R01618 RC00002,RC02753,RC02795 ko00000,ko00001,ko01000 Bacteria 2GJT5@201174,COG0537@1,COG0537@2 NA|NA|NA FG Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases MAG.T1.179_01579 1048339.KB913029_gene3748 1e-77 297.0 Frankiales ypfJ GO:0005575,GO:0005576 ko:K07054 ko00000 Bacteria 2H3UT@201174,4ES25@85013,COG2321@1,COG2321@2 NA|NA|NA S Putative neutral zinc metallopeptidase MAG.T1.179_01580 479432.Sros_5972 1.3e-208 732.6 Streptosporangiales ybiT Bacteria 2GKQ4@201174,4EG0G@85012,COG0488@1,COG0488@2 NA|NA|NA S ABC transporter MAG.T1.179_01581 1463845.JOIG01000007_gene549 9e-12 75.9 Actinobacteria Bacteria 2E4I7@1,2IQBB@201174,32ZDA@2 NA|NA|NA S transcriptional regulator MAG.T1.179_01582 566461.SSFG_05534 2.9e-65 255.4 Actinobacteria echA Bacteria 2GKC4@201174,COG1024@1,COG1024@2 NA|NA|NA I Belongs to the enoyl-CoA hydratase isomerase family MAG.T1.179_01583 1122138.AQUZ01000001_gene1538 1.1e-222 779.6 Propionibacteriales msbA9 ko:K06147 ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 Bacteria 2GITR@201174,4DN7W@85009,COG1132@1,COG1132@2 NA|NA|NA V ABC transporter transmembrane region MAG.T1.179_01584 1048339.KB913029_gene4318 9.5e-72 276.9 Frankiales Bacteria 2GMEH@201174,4EUCD@85013,COG1028@1,COG1028@2 NA|NA|NA IQ KR domain MAG.T1.179_01585 28042.GU90_11695 1.8e-31 143.3 Pseudonocardiales Bacteria 2GRSQ@201174,4DYIC@85010,COG4759@1,COG4759@2 NA|NA|NA O Sucrase/ferredoxin-like MAG.T1.179_01586 446466.Cfla_1693 5.4e-291 1006.9 Cellulomonadaceae gyrA GO:0005575,GO:0005622,GO:0005623,GO:0009330,GO:0032991,GO:0044424,GO:0044464 5.99.1.3 ko:K02469,ko:K02621 ko00000,ko01000,ko02048,ko03032,ko03036,ko03400 Bacteria 2GJ2Q@201174,4F1NX@85016,COG0188@1,COG0188@2 NA|NA|NA L SMART DNA gyrase topoisomerase IV subunit A MAG.T1.179_01587 1123320.KB889707_gene7976 8e-235 820.5 Actinobacteria iAF987.Gmet_2142 Bacteria 2GKN1@201174,COG0454@1,COG0456@2,COG1042@1,COG1042@2 NA|NA|NA C CoA-binding domain protein MAG.T1.179_01588 1120950.KB892748_gene3185 8.5e-54 216.9 Propionibacteriales Bacteria 29850@1,2GKR1@201174,2ZVAX@2,4DQC6@85009 NA|NA|NA MAG.T1.179_01589 477641.MODMU_3477 4.9e-74 285.0 Frankiales Bacteria 2GISU@201174,4ESFM@85013,COG1524@1,COG1524@2 NA|NA|NA S PFAM type I phosphodiesterase nucleotide pyrophosphatase MAG.T1.179_01590 590998.Celf_2152 3.5e-49 202.6 Cellulomonadaceae GO:0008150,GO:0040007 Bacteria 28PUQ@1,2GNQM@201174,2ZCFK@2,4F1CN@85016 NA|NA|NA S Protein of unknown function (DUF3071) MAG.T1.179_01591 68223.JNZY01000006_gene4113 8.4e-100 370.5 Actinobacteria hemH GO:0003674,GO:0003824,GO:0004325,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0046148,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051540,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJTQ@201174,COG0276@1,COG0276@2 NA|NA|NA H Catalyzes the ferrous insertion into protoporphyrin IX MAG.T1.179_01592 1348663.KCH_54540 2.2e-66 259.2 Kitasatospora suhB 3.1.3.25,4.99.1.1,4.99.1.9 ko:K01092,ko:K01772 ko00521,ko00562,ko00860,ko01100,ko01110,ko04070,map00521,map00562,map00860,map01100,map01110,map04070 M00121,M00131 R00310,R01185,R01186,R01187,R11329 RC00078,RC01012 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJQE@201174,2M1IQ@2063,COG0483@1,COG0483@2 NA|NA|NA G Inositol monophosphatase family MAG.T1.179_01593 710111.FraQA3DRAFT_2974 1.6e-43 182.6 Frankiales Bacteria 2GP22@201174,4EVCG@85013,COG0663@1,COG0663@2 NA|NA|NA S Bacterial transferase hexapeptide (six repeats) MAG.T1.179_01594 1184609.KILIM_083_00160 3.4e-38 164.1 Dermatophilaceae Bacteria 2ATJW@1,2IKN0@201174,31J3Z@2,4F70K@85018 NA|NA|NA S Domain of unknown function (DUF4193) MAG.T1.179_01596 935839.JAGJ01000003_gene1380 4.7e-18 97.8 Promicromonosporaceae Bacteria 2E4C2@1,2IFS5@201174,32Z7M@2,4F4VX@85017 NA|NA|NA S Protein of unknown function (DUF3093) MAG.T1.179_01597 68260.JOAY01000013_gene2772 2.3e-51 208.8 Actinobacteria Bacteria 2GKY1@201174,COG2050@1,COG2050@2 NA|NA|NA Q PFAM thioesterase superfamily MAG.T1.179_01598 1348663.KCH_54620 4.7e-60 237.3 Kitasatospora dut GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23,4.1.1.36,6.3.2.5 ko:K01520,ko:K13038 ko00240,ko00770,ko00983,ko01100,map00240,map00770,map00983,map01100 M00053,M00120 R02100,R03269,R04231,R11896 RC00002,RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000,ko03400 Bacteria 2IHYY@201174,2M2SY@2063,COG0756@1,COG0756@2 NA|NA|NA F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA MAG.T1.179_01599 593907.Celgi_1460 1.3e-49 203.4 Cellulomonadaceae Bacteria 28J4D@1,2I2E9@201174,30NZ9@2,4F14W@85016 NA|NA|NA S Protein of unknown function (DUF3710) MAG.T1.179_01600 1048339.KB913029_gene3870 5.3e-31 140.6 Frankiales 3.6.4.12 ko:K03655 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 2IHRX@201174,4ETC1@85013,COG1200@1,COG1200@2 NA|NA|NA KL Nucleic acid binding, OB-fold, tRNA MAG.T1.179_01601 1120950.KB892748_gene3215 2e-46 192.6 Propionibacteriales Bacteria 2AVV0@1,2GJKP@201174,31MNQ@2,4DQXN@85009 NA|NA|NA S Protein of unknown function (DUF3159) MAG.T1.179_01602 1122611.KB903954_gene5626 4.9e-82 310.8 Streptosporangiales trkA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03499 ko00000,ko02000 2.A.38.1,2.A.38.4 Bacteria 2GKB9@201174,4EGQI@85012,COG0569@1,COG0569@2 NA|NA|NA P TrkA-N domain MAG.T1.179_01603 1133850.SHJG_6974 8.1e-77 293.5 Actinobacteria ceoB ko:K03499 ko00000,ko02000 2.A.38.1,2.A.38.4 Bacteria 2GK4N@201174,COG0569@1,COG0569@2 NA|NA|NA P PFAM TrkA-N domain protein MAG.T1.179_01604 479432.Sros_6758 3.6e-227 794.7 Streptosporangiales Bacteria 2GK5V@201174,4EH63@85012,COG0531@1,COG0531@2 NA|NA|NA E Amino acid permease MAG.T1.179_01605 1048339.KB913029_gene3874 4.7e-91 341.7 Frankiales trmA GO:0000049,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016740,GO:0016741,GO:0019843,GO:0030488,GO:0030696,GO:0030697,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363 2.1.1.190,2.1.1.35 ko:K00557,ko:K03215 ko00000,ko01000,ko03009,ko03016 Bacteria 2GIR3@201174,4ERZK@85013,COG2265@1,COG2265@2 NA|NA|NA J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family MAG.T1.179_01606 1121946.AUAX01000008_gene7232 0.0 1366.7 Micromonosporales acnA GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005506,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008198,GO:0009060,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0030312,GO:0030350,GO:0032787,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046459,GO:0046872,GO:0046914,GO:0047456,GO:0048037,GO:0050896,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2GJD5@201174,4DBYB@85008,COG1048@1,COG1048@2 NA|NA|NA C aconitate hydratase MAG.T1.179_01607 1146883.BLASA_3285 5.4e-22 110.5 Actinobacteria Bacteria 2E8DB@1,2IHS0@201174,332RT@2 NA|NA|NA MAG.T1.179_01608 743718.Isova_1764 2.6e-229 801.6 Promicromonosporaceae dxs GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006725,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008614,GO:0008615,GO:0008654,GO:0008661,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009240,GO:0009987,GO:0016740,GO:0016744,GO:0017144,GO:0018130,GO:0019288,GO:0019438,GO:0019637,GO:0019682,GO:0019752,GO:0019842,GO:0030976,GO:0032787,GO:0034641,GO:0036094,GO:0042180,GO:0042181,GO:0042364,GO:0042723,GO:0042724,GO:0042816,GO:0042819,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046490,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:1901135,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663,GO:1901681 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 iEcSMS35_1347.EcSMS35_0456,iIT341.HP0354,iJN746.PP_0527 Bacteria 2GMFA@201174,4F36H@85017,COG1154@1,COG1154@2 NA|NA|NA H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) MAG.T1.179_01609 345341.KUTG_00976 1.4e-88 334.0 Pseudonocardiales Bacteria 2GIZF@201174,4DYN9@85010,COG5001@1,COG5001@2 NA|NA|NA T Diguanylate cyclase MAG.T1.179_01610 1463858.JOHR01000014_gene5354 2.6e-125 455.7 Actinobacteria rnd 3.1.13.5 ko:K03684 ko00000,ko01000,ko03016 Bacteria 2GKNM@201174,COG0349@1,COG0349@2 NA|NA|NA J 3-5 exonuclease MAG.T1.179_01611 1137271.AZUM01000001_gene1482 2.3e-25 122.5 Pseudonocardiales Bacteria 2GIXT@201174,4DXKI@85010,COG2197@1,COG2197@2 NA|NA|NA K response regulator MAG.T1.179_01612 1298863.AUEP01000018_gene3870 2.2e-54 218.8 Propionibacteriales Bacteria 2AIF4@1,2GK8R@201174,318WM@2,4DQE6@85009 NA|NA|NA S Protein of unknown function (DUF3000) MAG.T1.179_01613 1385519.N801_01520 1.7e-47 196.4 Intrasporangiaceae Bacteria 2GM50@201174,4FGFA@85021,COG0697@1,COG0697@2 NA|NA|NA EG EamA-like transporter family MAG.T1.179_01615 1380346.JNIH01000057_gene20 7.1e-119 434.5 Actinobacteria hemG 1.3.3.15,1.3.3.4 ko:K00231 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03222,R04178 RC00885 ko00000,ko00001,ko00002,ko01000 Bacteria 2GMMA@201174,COG1232@1,COG1232@2 NA|NA|NA H Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX MAG.T1.179_01616 585531.HMPREF0063_10544 3e-85 321.6 Propionibacteriales hemH GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 Bacteria 2GK24@201174,4DP69@85009,COG3253@1,COG3253@2 NA|NA|NA S Chlorite dismutase MAG.T1.179_01617 640132.Srot_1648 1.7e-57 228.8 Actinobacteria msrB 1.8.4.12 ko:K07305 ko00000,ko01000 Bacteria 2IHV0@201174,COG0229@1,COG0229@2 NA|NA|NA O peptide-methionine (R)-S-oxide reductase MAG.T1.179_01618 1048339.KB913029_gene3893 1.6e-138 499.2 Frankiales Bacteria 2GM0A@201174,4ES0F@85013,COG3285@1,COG3285@2 NA|NA|NA L DNA polymerase LigD MAG.T1.179_01620 1136417.AZWE01000018_gene977 1.7e-77 296.6 Micromonosporales ligC Bacteria 2I2EA@201174,4DA61@85008,COG1793@1,COG1793@2 NA|NA|NA L DNA ligase MAG.T1.179_01621 479431.Namu_3543 1.2e-29 136.7 Frankiales ribG 1.1.1.193,3.5.4.26 ko:K00082,ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 Bacteria 2GN2P@201174,4ET37@85013,COG1985@1,COG1985@2 NA|NA|NA H PFAM bifunctional deaminase-reductase domain protein MAG.T1.179_01622 1449346.JQMO01000002_gene2006 1.6e-119 436.0 Kitasatospora ko:K06916 ko00000,ko03036 Bacteria 2GNQA@201174,2M1G2@2063,COG1485@1,COG1485@2 NA|NA|NA S AFG1-like ATPase MAG.T1.179_01623 55952.BU52_14505 1.4e-14 86.3 Actinobacteria Bacteria 2EA6A@1,2II4E@201174,334B4@2 NA|NA|NA S Domain of unknown function (DUF4439) MAG.T1.179_01624 1449355.JQNR01000005_gene4681 2.6e-08 65.5 Actinobacteria Bacteria 2EUHF@1,2ISV6@201174,33MZK@2 NA|NA|NA MAG.T1.179_01625 1245475.ANAE01000075_gene2816 6.1e-40 170.6 Streptosporangiales rimP GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576 ko:K09748 ko00000,ko03009 Bacteria 2I9BT@201174,4EJF1@85012,COG0779@1,COG0779@2 NA|NA|NA S Required for maturation of 30S ribosomal subunits MAG.T1.179_01626 44060.JODL01000009_gene1920 1.2e-132 479.6 Actinobacteria nusA GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0040007,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 ko:K02600 ko00000,ko03009,ko03021 Bacteria 2GJDJ@201174,COG0195@1,COG0195@2 NA|NA|NA K Participates in both transcription termination and antitermination MAG.T1.179_01627 397278.JOJN01000001_gene2901 6.3e-30 137.1 Propionibacteriales flgD ko:K02389 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 2IQIQ@201174,4DS0Z@85009,COG1843@1,COG1843@2 NA|NA|NA N Flagellar hook capping protein - N-terminal region MAG.T1.179_01628 397278.JOJN01000001_gene2902 7.2e-110 403.7 Propionibacteriales flgG GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009424,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588 ko:K02390 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 2I3KN@201174,4DNCD@85009,COG4786@1,COG4786@2 NA|NA|NA N Flagellar basal body rod FlgEFG protein C-terminal MAG.T1.179_01629 196162.Noca_0750 1.4e-14 85.5 Propionibacteriales flbD ko:K02385 ko00000,ko02035 Bacteria 2GRTC@201174,4DVPB@85009,COG1582@1,COG1582@2 NA|NA|NA N Flagellar protein (FlbD) MAG.T1.179_01630 1283287.KB822581_gene1417 3.4e-98 364.8 Propionibacteriales motA ko:K02556 ko02020,ko02030,ko02040,map02020,map02030,map02040 ko00000,ko00001,ko02000,ko02035 1.A.30.1 Bacteria 2I92C@201174,4DP5S@85009,COG1291@1,COG1291@2 NA|NA|NA N MotA/TolQ/ExbB proton channel family MAG.T1.179_01631 1298863.AUEP01000003_gene2824 2.4e-79 302.4 Propionibacteriales motB ko:K02557 ko02030,ko02040,map02030,map02040 ko00000,ko00001,ko02000,ko02035 1.A.30.1 Bacteria 2IG81@201174,4DTTH@85009,COG1360@1,COG1360@2 NA|NA|NA N Membrane MotB of proton-channel complex MotA/MotB MAG.T1.179_01632 935866.JAER01000042_gene2752 8.2e-28 130.2 Propionibacteriales fliL ko:K02415 ko00000,ko02035 Bacteria 2ITFQ@201174,4DV67@85009,COG1580@1,COG1580@2 NA|NA|NA N Flagellar basal body-associated protein FliL MAG.T1.179_01633 1283287.KB822581_gene1414 2.6e-87 328.9 Propionibacteriales fliM ko:K02416,ko:K02417 ko02030,ko02040,map02030,map02040 ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 Bacteria 2ICP2@201174,4DNNZ@85009,COG1868@1,COG1868@2 NA|NA|NA N Flagellar motor switch protein FliM MAG.T1.179_01634 196162.Noca_0745 2.4e-35 156.0 Propionibacteriales fliN ko:K02417 ko02030,ko02040,map02030,map02040 ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 Bacteria 2IGHQ@201174,4DREH@85009,COG1886@1,COG1886@2 NA|NA|NA NU Type III flagellar switch regulator (C-ring) FliN C-term MAG.T1.179_01635 196162.Noca_0744 2.8e-20 105.1 Propionibacteriales fliP ko:K02418,ko:K02419 ko02040,map02040 ko00000,ko00001,ko02035,ko02044 3.A.6.2 Bacteria 2GREW@201174,4DVDJ@85009,COG3190@1,COG3190@2 NA|NA|NA N Flagellar biosynthesis protein, FliO MAG.T1.179_01636 935866.JAER01000042_gene2756 5.7e-74 285.0 Propionibacteriales fliP ko:K02419,ko:K03226 ko02040,ko03070,map02040,map03070 M00332,M00542,M00660 ko00000,ko00001,ko00002,ko02035,ko02044 3.A.6.1,3.A.6.2,3.A.6.3 Bacteria 2GP63@201174,4DPT8@85009,COG1338@1,COG1338@2 NA|NA|NA NU FliP family MAG.T1.179_01637 397278.JOJN01000001_gene2924 4.7e-31 140.2 Propionibacteriales fliQ ko:K02420 ko02040,map02040 ko00000,ko00001,ko02035,ko02044 3.A.6.2 Bacteria 2IQ8H@201174,4DRPB@85009,COG1987@1,COG1987@2 NA|NA|NA NU Bacterial export proteins, family 3 MAG.T1.179_01638 1298863.AUEP01000003_gene2817 5e-78 297.7 Propionibacteriales fliR ko:K02421,ko:K03228,ko:K13820 ko02040,ko03070,map02040,map03070 M00332,M00542,M00660 ko00000,ko00001,ko00002,ko02035,ko02044 3.A.6.1,3.A.6.2,3.A.6.3 Bacteria 2IDEX@201174,4DPR0@85009,COG1684@1,COG1684@2 NA|NA|NA NU Bacterial export proteins, family 1 MAG.T1.179_01639 1033730.CAHG01000007_gene2549 3e-117 428.7 Propionibacteriales flhB GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K02401,ko:K02556,ko:K03229,ko:K04061,ko:K13820 ko02020,ko02030,ko02040,ko03070,map02020,map02030,map02040,map03070 M00332,M00542,M00660 ko00000,ko00001,ko00002,ko02000,ko02035,ko02044 1.A.30.1,3.A.6.1,3.A.6.2,3.A.6.3 Bacteria 2HF6J@201174,4DQ2U@85009,COG1377@1,COG1377@2 NA|NA|NA NU FlhB HrpN YscU SpaS Family MAG.T1.179_01640 1298863.AUEP01000003_gene2815 2.1e-259 901.7 Propionibacteriales flhA GO:0005575,GO:0005623,GO:0005886,GO:0006996,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0022607,GO:0030030,GO:0030031,GO:0044085,GO:0044464,GO:0044780,GO:0044781,GO:0070925,GO:0071840,GO:0071944 ko:K02400 ko02040,map02040 ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 Bacteria 2IB5S@201174,4DP8V@85009,COG1298@1,COG1298@2 NA|NA|NA NU Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin MAG.T1.179_01642 1283287.KB822581_gene1520 9.2e-23 112.5 Propionibacteriales csrA ko:K03563,ko:K13626 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 ko00000,ko00001,ko02035,ko03019 Bacteria 2GRPH@201174,4DS3Q@85009,COG1551@1,COG1551@2 NA|NA|NA T Global regulator protein family MAG.T1.179_01643 1298863.AUEP01000003_gene2847 4.4e-36 157.5 Propionibacteriales fliW ko:K13626 ko00000,ko02035 Bacteria 2GT61@201174,4DRPC@85009,COG1699@1,COG1699@2 NA|NA|NA S Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum MAG.T1.179_01644 196162.Noca_0770 6.9e-79 300.8 Propionibacteriales flgL GO:0005575,GO:0005576,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464 ko:K02397 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 2IA40@201174,4DNBS@85009,COG1344@1,COG1344@2 NA|NA|NA N Bacterial flagellin C-terminal helical region MAG.T1.179_01645 196162.Noca_0769 8.2e-127 460.7 Propionibacteriales flgK ko:K02396 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 2GNXQ@201174,4DNRW@85009,COG1256@1,COG1256@2 NA|NA|NA N Flagellar basal body rod FlgEFG protein C-terminal MAG.T1.179_01646 1298863.AUEP01000003_gene2844 2.8e-42 178.3 Propionibacteriales flgN Bacteria 2B12R@1,2IQ5J@201174,31TG8@2,4DRX1@85009 NA|NA|NA S FlgN protein MAG.T1.179_01648 1035308.AQYY01000001_gene2568 7.4e-264 916.4 Peptococcaceae glgB GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0071704,GO:1901576 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 ko00000,ko00001,ko00002,ko01000,ko04147 CBM48,GH13 Bacteria 1TP4M@1239,247WH@186801,260UV@186807,COG0296@1,COG0296@2 NA|NA|NA G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position MAG.T1.179_01649 649831.L083_4309 4.6e-33 147.9 Micromonosporales Bacteria 2IK2E@201174,4DIYC@85008,COG1309@1,COG1309@2 NA|NA|NA K Bacterial regulatory proteins, tetR family MAG.T1.179_01651 1150399.AQYK01000001_gene1603 1.8e-39 171.4 Microbacteriaceae yhgE ko:K01421 ko00000 Bacteria 2GKEM@201174,4FM86@85023,COG1511@1,COG1511@2 NA|NA|NA S YhgE Pip domain protein MAG.T1.179_01652 1150399.AQYK01000001_gene1604 2.4e-231 808.9 Microbacteriaceae ko:K06994 ko00000 Bacteria 2GJ5A@201174,4FK7G@85023,COG1033@1,COG1033@2,COG2409@1,COG2409@2 NA|NA|NA D MMPL family MAG.T1.179_01653 1463861.JNXE01000006_gene5743 7e-43 180.3 Actinobacteria furA ko:K03711,ko:K22297 ko00000,ko03000 Bacteria 2IFBR@201174,COG0735@1,COG0735@2 NA|NA|NA P Belongs to the Fur family MAG.T1.179_01654 134676.ACPL_8199 0.0 1103.6 Micromonosporales katG GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 Bacteria 2GJFP@201174,4D8UR@85008,COG0376@1,COG0376@2 NA|NA|NA P Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity MAG.T1.179_01656 2045.KR76_07085 2.6e-31 142.1 Propionibacteriales VY92_09940 ko:K09796 ko00000,ko03110 Bacteria 2IR3D@201174,4DS2B@85009,COG2847@1,COG2847@2 NA|NA|NA S Copper chaperone PCu(A)C MAG.T1.179_01657 1179773.BN6_18910 6.3e-31 140.6 Pseudonocardiales XK27_02315 Bacteria 2IMR2@201174,4E5VC@85010,COG5646@1,COG5646@2 NA|NA|NA S Domain of unknown function (DU1801) MAG.T1.179_01658 1240349.ANGC01000051_gene4101 3.7e-148 531.6 Nocardiaceae Bacteria 2CA5R@1,2GM6V@201174,2Z81H@2,4FVE9@85025 NA|NA|NA MAG.T1.179_01659 1713.JOFV01000017_gene106 6.8e-41 173.3 Cellulomonadaceae ywzG Bacteria 2IQSE@201174,4F1CD@85016,COG1695@1,COG1695@2 NA|NA|NA K Transcriptional regulator PadR-like family MAG.T1.179_01660 590998.Celf_2836 3.5e-115 422.2 Cellulomonadaceae ydhC ko:K07552,ko:K18552 br01600,ko00000,ko01504,ko02000 2.A.1.2,2.A.1.2.3 Bacteria 2I2Q2@201174,4F0N0@85016,COG0477@1,COG0477@2 NA|NA|NA EGP TIGRFAM drug resistance transporter, Bcr CflA subfamily MAG.T1.179_01661 408672.NBCG_01925 8.3e-93 347.1 Propionibacteriales 3.2.1.83 ko:K20846 ko00000,ko01000 GH16 Bacteria 2GTJC@201174,4DQGW@85009,COG2273@1,COG2273@2 NA|NA|NA G Glycosyl hydrolases family 16 MAG.T1.179_01662 1120950.KB892775_gene1183 3.4e-127 461.8 Propionibacteriales arsB Bacteria 2GMQJ@201174,4DN5A@85009,COG1055@1,COG1055@2 NA|NA|NA P Bacterial Na+/H+ antiporter B (NhaB) MAG.T1.179_01663 710421.Mycch_1475 1.3e-96 359.4 Mycobacteriaceae ahpC 1.11.1.15 ko:K03386 ko04214,map04214 ko00000,ko00001,ko01000,ko04147 Bacteria 234SP@1762,2GM74@201174,COG0450@1,COG0450@2 NA|NA|NA O Alkyl hydroperoxide reductase MAG.T1.179_01664 526222.Desal_3467 1.7e-67 263.1 Desulfovibrionales Bacteria 1RAKG@1224,2MAVS@213115,2WN6A@28221,42QYD@68525,COG2199@1,COG3706@2 NA|NA|NA T Diguanylate cyclase, GGDEF domain MAG.T1.179_01665 937777.Deipe_2178 1.3e-29 137.9 Bacteria 3.4.21.107 ko:K04771,ko:K08372 ko01503,ko02020,map01503,map02020 M00728 ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 Bacteria COG0265@1,COG0265@2 NA|NA|NA O serine-type endopeptidase activity MAG.T1.179_01666 1035308.AQYY01000001_gene1812 2.1e-87 329.7 Bacteria Bacteria COG4325@1,COG4325@2 NA|NA|NA MAG.T1.179_01667 671143.DAMO_1527 7.2e-63 247.7 unclassified Bacteria yrbG ko:K07301 ko00000,ko02000 2.A.19.5 Bacteria 2NPPD@2323,COG0530@1,COG0530@2 NA|NA|NA P Sodium/calcium exchanger protein MAG.T1.179_01668 103733.JNYO01000019_gene2036 3.5e-119 434.9 Pseudonocardiales Bacteria 2C1EG@1,2GK4W@201174,2Z7MZ@2,4DZP1@85010 NA|NA|NA MAG.T1.179_01669 471853.Bcav_3980 5.6e-152 544.3 Actinobacteria Bacteria 2GJ8H@201174,COG3119@1,COG3119@2 NA|NA|NA P Pfam Sulfatase MAG.T1.179_01670 1035308.AQYY01000001_gene2432 9.1e-40 169.9 Clostridia Bacteria 1VQQ3@1239,255AM@186801,COG5646@1,COG5646@2 NA|NA|NA S Domain of unknown function (DU1801) MAG.T1.179_01671 882083.SacmaDRAFT_2733 4.8e-35 155.6 Pseudonocardiales crtY 1.14.19.49,5.5.1.19 ko:K06443,ko:K14257 ko00253,ko00404,ko00906,ko01057,ko01100,ko01110,ko01130,map00253,map00404,map00906,map01057,map01100,map01110,map01130 M00097,M00790,M00823 R03824,R04801,R05341,R05456,R06962,R07856,R11106,R11478 RC00949,RC01004,RC01964 ko00000,ko00001,ko00002,ko01000 Bacteria 2GNH7@201174,4E8RQ@85010,COG0644@1,COG0644@2 NA|NA|NA C Lycopene cyclase protein MAG.T1.179_01672 1304865.JAGF01000001_gene3502 7.2e-68 263.8 Cellulomonadaceae Bacteria 2HD07@201174,4F18I@85016,COG1309@1,COG1309@2 NA|NA|NA K Bacterial regulatory proteins, tetR family MAG.T1.179_01673 1304865.JAGF01000001_gene3501 3.5e-94 351.3 Cellulomonadaceae ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GKEH@201174,4F0VG@85016,COG1131@1,COG1131@2 NA|NA|NA V PFAM ABC transporter related MAG.T1.179_01676 561175.KB894094_gene2083 0.0 1506.5 Streptosporangiales sucA GO:0000287,GO:0003674,GO:0003824,GO:0004591,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016624,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0019842,GO:0022900,GO:0030312,GO:0030976,GO:0032991,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0048037,GO:0050439,GO:0050662,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234 1.2.4.2,4.1.1.71 ko:K00164,ko:K01616 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1248c,iSSON_1240.SSON_0677,iYL1228.KPN_00732 Bacteria 2GIU6@201174,4EHHS@85012,COG0508@1,COG0508@2,COG0567@1,COG0567@2 NA|NA|NA C 2-oxoglutarate dehydrogenase C-terminal MAG.T1.179_01677 1122622.ATWJ01000012_gene997 3.7e-18 96.7 Intrasporangiaceae Bacteria 2E460@1,2GQGS@201174,32Z20@2,4FHQE@85021 NA|NA|NA MAG.T1.179_01678 1123322.KB904735_gene1568 5.5e-100 371.3 Actinobacteria patB 4.4.1.8 ko:K14155 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 R00782,R01286,R02408,R04941 RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303 ko00000,ko00001,ko01000,ko01007 Bacteria 2GJFQ@201174,COG1168@1,COG1168@2 NA|NA|NA E Aminotransferase, class I MAG.T1.179_01679 66875.JODY01000003_gene3452 6.8e-22 111.3 Actinobacteria Bacteria 2GS51@201174,COG2138@1,COG2138@2 NA|NA|NA P cobalamin (vitamin B12) biosynthesis CbiX protein MAG.T1.179_01680 1713.JOFV01000005_gene2127 4.6e-105 388.3 Cellulomonadaceae cysG GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009628,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.13.11.79,1.3.1.76,2.1.1.107,4.99.1.4 ko:K02302,ko:K02303,ko:K02304,ko:K04719 ko00740,ko00860,ko01100,ko01110,ko01120,map00740,map00860,map01100,map01110,map01120 M00121 R02864,R03194,R03947,R09083 RC00003,RC00435,RC00871,RC01012,RC01034,RC02413 ko00000,ko00001,ko00002,ko01000 iECIAI1_1343.ECIAI1_3507,iECSE_1348.ECSE_3630,iEcE24377_1341.EcE24377A_3838,iJN746.PP_3999,iPC815.YPO0158 Bacteria 2GK3B@201174,4F0HX@85016,COG0007@1,COG0007@2 NA|NA|NA H PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase MAG.T1.179_01681 446462.Amir_1235 1.5e-148 532.7 Pseudonocardiales cysN 2.7.1.25,2.7.7.4 ko:K00955,ko:K00956 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00509,R00529,R04928,R04929 RC00002,RC00078,RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJDX@201174,4DYZW@85010,COG2895@1,COG2895@2 NA|NA|NA P Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily MAG.T1.179_01682 1306406.ASHX01000002_gene4651 4.6e-142 510.8 Actinobacteria cysD 1.8.4.10,1.8.4.8,2.7.7.4 ko:K00390,ko:K00957 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R02021,R04929 RC00007,RC02809,RC02862,RC02889 ko00000,ko00001,ko00002,ko01000 Bacteria 2GN85@201174,COG0175@1,COG0175@2 NA|NA|NA EH sulfate adenylyltransferase MAG.T1.179_01683 593907.Celgi_1496 1.6e-81 309.3 Cellulomonadaceae cysH GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004604,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016667,GO:0016671,GO:0019344,GO:0019752,GO:0040007,GO:0043436,GO:0043866,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.8.4.10,1.8.4.8 ko:K00390 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R02021 RC00007,RC02862 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv2392 Bacteria 2GJ3Z@201174,4F0TA@85016,COG0175@1,COG0175@2 NA|NA|NA EH Belongs to the PAPS reductase family. CysH subfamily MAG.T1.179_01684 1121946.AUAX01000030_gene1321 1.2e-10 72.0 Micromonosporales Bacteria 2GQKE@201174,4DGEE@85008,COG3677@1,COG3677@2 NA|NA|NA L Transposase MAG.T1.179_01685 862751.SACTE_5342 2.9e-227 794.7 Actinobacteria sir GO:0000096,GO:0000097,GO:0000103,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016002,GO:0016053,GO:0016491,GO:0016667,GO:0016673,GO:0019344,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050311,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.14.13.83,1.7.7.1,1.8.7.1 ko:K00366,ko:K00392,ko:K02229 ko00860,ko00910,ko00920,ko01100,ko01120,map00860,map00910,map00920,map01100,map01120 M00176,M00531 R00790,R00859,R03600,R05217 RC00065,RC00176,RC01979 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJRN@201174,COG0155@1,COG0155@2 NA|NA|NA C Belongs to the nitrite and sulfite reductase 4Fe-4S domain family MAG.T1.179_01687 717773.Thicy_0930 1.3e-62 246.9 Bacteria Bacteria COG1887@1,COG1887@2 NA|NA|NA M Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC MAG.T1.179_01688 1341646.CBMO010000035_gene4653 3e-139 502.3 Mycobacteriaceae sulP GO:0000103,GO:0000166,GO:0003333,GO:0003674,GO:0005215,GO:0005310,GO:0005326,GO:0005342,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006790,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0008152,GO:0008272,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015103,GO:0015116,GO:0015138,GO:0015141,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015238,GO:0015318,GO:0015556,GO:0015698,GO:0015711,GO:0015740,GO:0015741,GO:0015744,GO:0015800,GO:0015807,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0017076,GO:0019001,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0036094,GO:0042221,GO:0042493,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070778,GO:0071422,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0097159,GO:0098656,GO:0098660,GO:0098661,GO:1901265,GO:1901363,GO:1901682,GO:1902358,GO:1902475,GO:1903825,GO:1905039 ko:K03321 ko00000,ko02000 2.A.53.3 Bacteria 236K7@1762,2GJCB@201174,COG0659@1,COG0659@2 NA|NA|NA P Sulfate transporter MAG.T1.179_01690 1122182.KB903816_gene1626 4.5e-26 123.2 Micromonosporales cspA ko:K03704 ko00000,ko03000 Bacteria 2GQRU@201174,4DEWR@85008,COG1278@1,COG1278@2 NA|NA|NA K Cold shock MAG.T1.179_01691 685727.REQ_34670 4.9e-187 661.0 Nocardiaceae cdr ko:K04085 ko04122,map04122 ko00000,ko00001,ko01000,ko03016 Bacteria 2H7WY@201174,4FX6B@85025,COG0446@1,COG0446@2,COG0607@1,COG0607@2 NA|NA|NA P Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain MAG.T1.179_01692 998088.B565_2809 7.1e-36 158.3 Aeromonadales Bacteria 1NEEG@1224,1RZMD@1236,1Y4XF@135624,COG4938@1,COG4938@2 NA|NA|NA D AAA ATPase domain MAG.T1.179_01694 1254432.SCE1572_32985 6.1e-28 132.5 Proteobacteria Bacteria 1N5ID@1224,COG3591@1,COG3591@2 NA|NA|NA E Belongs to the peptidase S1B family MAG.T1.179_01695 390989.JOEG01000001_gene5220 1e-126 460.3 Micromonosporales argE Bacteria 2GM84@201174,4D8NU@85008,COG0624@1,COG0624@2 NA|NA|NA E Peptidase dimerisation domain MAG.T1.179_01697 351607.Acel_0628 6.2e-206 723.8 Frankiales argS GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 iAF987.Gmet_1434 Bacteria 2GKQ3@201174,4ERR2@85013,COG0018@1,COG0018@2 NA|NA|NA J Arginyl-tRNA synthetase MAG.T1.179_01698 2074.JNYD01000014_gene7070 3.1e-16 92.8 Pseudonocardiales ko:K07058 ko00000 Bacteria 2GM6P@201174,4E0J5@85010,COG1295@1,COG1295@2 NA|NA|NA S Virulence factor BrkB MAG.T1.179_01699 1211815.CBYP010000042_gene2347 9.9e-160 570.1 Frankiales lysA 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKAI@201174,4ERM5@85013,COG0019@1,COG0019@2 NA|NA|NA E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine MAG.T1.179_01700 222534.KB893751_gene4136 3.9e-131 474.9 Frankiales hom GO:0003674,GO:0003824,GO:0004412,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1294,iSB619.SA_RS06610 Bacteria 2GIX9@201174,4ERJB@85013,COG0460@1,COG0460@2 NA|NA|NA E homoserine dehydrogenase MAG.T1.179_01701 1463920.JOGB01000028_gene5208 5.6e-139 500.7 Actinobacteria thrC GO:0003674,GO:0003824,GO:0004795,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 iLJ478.TM0546,iSB619.SA_RS06615,iYO844.BSU32250 Bacteria 2GJ5F@201174,COG0498@1,COG0498@2 NA|NA|NA E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine MAG.T1.179_01702 593907.Celgi_2478 3.7e-67 261.9 Cellulomonadaceae thrB GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.1.39 ko:K00872 ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230 M00018 R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 iECSE_1348.ECSE_0003,iJN678.thrB,iLJ478.TM0545,iSB619.SA_RS06620 Bacteria 2GKIW@201174,4F0RU@85016,COG0083@1,COG0083@2 NA|NA|NA E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate MAG.T1.179_01703 1048339.KB913029_gene3381 6.2e-183 647.5 Frankiales rho GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006351,GO:0006353,GO:0006360,GO:0006363,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576 ko:K03628 ko03018,map03018 ko00000,ko00001,ko03019,ko03021 Bacteria 2GIWY@201174,4ERDG@85013,COG1158@1,COG1158@2 NA|NA|NA K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template MAG.T1.179_01704 1449069.JMLO01000004_gene3655 2.8e-123 448.7 Nocardiaceae proP Bacteria 2I2EY@201174,4G9I9@85025,COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily MAG.T1.179_01705 471852.Tcur_3932 1.3e-28 131.7 Streptosporangiales rpmE ko:K02909 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IQ4I@201174,4EK8U@85012,COG0254@1,COG0254@2 NA|NA|NA J Binds the 23S rRNA MAG.T1.179_01706 1449353.JQMQ01000005_gene2192 8.7e-137 493.4 Streptacidiphilus prfA ko:K02835 ko00000,ko03012 Bacteria 2GJWG@201174,2NGSW@228398,COG0216@1,COG0216@2 NA|NA|NA J PCRF MAG.T1.179_01707 1120950.KB892745_gene2866 6.4e-67 261.2 Propionibacteriales prmC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464 2.1.1.297 ko:K02493 R10806 RC00003,RC03279 ko00000,ko01000,ko03012 Bacteria 2GMH1@201174,4DP23@85009,COG2890@1,COG2890@2 NA|NA|NA J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif MAG.T1.179_01708 222534.KB893751_gene4143 1.2e-40 173.3 Frankiales ywlC GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 2.7.7.87 ko:K07566 R10463 RC00745 ko00000,ko01000,ko03009,ko03016 Bacteria 2GK2X@201174,4ESEK@85013,COG0009@1,COG0009@2 NA|NA|NA J Belongs to the SUA5 family MAG.T1.179_01709 1146883.BLASA_3927 5.8e-188 663.7 Frankiales glyA 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 Bacteria 2GK7U@201174,4ERC5@85013,COG0112@1,COG0112@2 NA|NA|NA E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism MAG.T1.179_01710 1504319.GM45_6060 2.6e-91 342.4 unclassified Actinobacteria (class) tagO GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016740,GO:0016772,GO:0016780,GO:0030145,GO:0034645,GO:0042546,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0045229,GO:0046872,GO:0046914,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:1901576 2.7.8.33,2.7.8.35 ko:K02851 R08856 RC00002 ko00000,ko01000,ko01003,ko01005 Bacteria 2GIT7@201174,3UWGE@52018,COG0472@1,COG0472@2 NA|NA|NA M Glycosyl transferase family 4 MAG.T1.179_01711 1713.JOFV01000002_gene496 1.1e-10 73.2 Cellulomonadaceae atpI ko:K02116 ko00000,ko00194 3.A.2.1 Bacteria 2BJAR@1,2GR4T@201174,32DKN@2,4F1BV@85016 NA|NA|NA MAG.T1.179_01712 1504319.GM45_6070 7.2e-14 83.2 Bacteria Bacteria 2972E@1,2ZUAS@2 NA|NA|NA MAG.T1.179_01713 1504319.GM45_6075 1.7e-68 266.2 unclassified Actinobacteria (class) atpB ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 Bacteria 2H3PR@201174,3UWN7@52018,COG0356@1,COG0356@2 NA|NA|NA C it plays a direct role in the translocation of protons across the membrane MAG.T1.179_01714 1504319.GM45_6080 1.5e-27 128.3 unclassified Actinobacteria (class) atpE GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 Bacteria 2HGDC@201174,3UWZI@52018,COG0636@1,COG0636@2 NA|NA|NA C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation MAG.T1.179_01715 1122175.ATXU01000001_gene931 5.5e-34 151.0 Microbacteriaceae atpF ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 Bacteria 2GJS4@201174,4FNEE@85023,COG0711@1,COG0711@2 NA|NA|NA C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) MAG.T1.179_01716 1343740.M271_17085 5.7e-48 198.0 Actinobacteria atpH ko:K02109,ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 Bacteria 2GMJ5@201174,COG0712@1,COG0712@2 NA|NA|NA C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation MAG.T1.179_01717 469371.Tbis_0898 2.4e-234 818.1 Pseudonocardiales atpA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 iIT341.HP1134,iSB619.SA_RS10975,iSbBS512_1146.SbBS512_E4187 Bacteria 2GJRJ@201174,4E0X3@85010,COG0056@1,COG0056@2 NA|NA|NA C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit MAG.T1.179_01718 1120950.KB892745_gene2878 1.4e-85 323.2 Propionibacteriales atpG GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 iLJ478.TM1611,iSSON_1240.SSON_3886,iYL1228.KPN_04138 Bacteria 2GJ7Q@201174,4DN4I@85009,COG0224@1,COG0224@2 NA|NA|NA C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex MAG.T1.179_01719 471853.Bcav_0498 5.8e-48 198.0 Actinobacteria ko:K07052 ko00000 Bacteria 2GYQG@201174,COG1266@1,COG1266@2 NA|NA|NA S CAAX protease self-immunity MAG.T1.179_01720 1386089.N865_13820 3.7e-209 734.6 Intrasporangiaceae Bacteria 2GKB5@201174,4FEF7@85021,COG4425@1,COG4425@2 NA|NA|NA S Alpha/beta-hydrolase family N-terminus MAG.T1.179_01722 717774.Marme_3571 6.5e-17 95.1 Bacteria Bacteria COG1357@1,COG1357@2 NA|NA|NA S protein homooligomerization MAG.T1.179_01723 1454010.JEOE01000008_gene1885 6.4e-153 547.4 Actinobacteria Bacteria 2GK3A@201174,COG1680@1,COG1680@2 NA|NA|NA V Beta-lactamase class C and other penicillin binding proteins MAG.T1.179_01724 1380354.JIAN01000005_gene2775 5e-108 397.5 Actinobacteria MA20_35565 4.1.3.30 ko:K03417 ko00640,map00640 R00409 RC00286,RC00287 ko00000,ko00001,ko01000 Bacteria 2GMQ4@201174,COG2513@1,COG2513@2 NA|NA|NA G COG2513 PEP phosphonomutase and related enzymes MAG.T1.179_01725 298655.KI912267_gene6624 1.7e-142 512.7 Frankiales yndJ Bacteria 28KUD@1,2IACK@201174,2ZAB6@2,4EUQM@85013 NA|NA|NA MAG.T1.179_01726 1172188.KB911820_gene2380 1e-92 346.3 Intrasporangiaceae Bacteria 2GMZV@201174,4FGJN@85021,COG0262@1,COG0262@2 NA|NA|NA H Deaminase reductase MAG.T1.179_01727 1121952.ATXT01000015_gene306 1.5e-65 256.9 Microbacteriaceae Bacteria 2AU69@1,2IFP7@201174,31JT7@2,4FRYV@85023 NA|NA|NA MAG.T1.179_01729 926564.KI911673_gene6308 7.5e-30 137.5 Actinobacteria Bacteria 2HRC6@201174,COG1280@1,COG1280@2 NA|NA|NA E Sap, sulfolipid-1-addressing protein MAG.T1.179_01731 367299.JOEE01000002_gene2522 2.1e-187 661.8 Intrasporangiaceae Bacteria 2GWBV@201174,4FE3R@85021,COG1672@1,COG1672@2 NA|NA|NA S AAA ATPase domain MAG.T1.179_01732 1032480.MLP_35440 3.3e-56 224.6 Propionibacteriales Bacteria 2ISME@201174,4DV13@85009,COG4767@1,COG4767@2 NA|NA|NA V VanZ like family MAG.T1.179_01733 471853.Bcav_3179 2.9e-96 359.0 Actinobacteria Bacteria 2H8PB@201174,COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily MAG.T1.179_01734 67352.JODS01000002_gene1441 3.9e-36 157.5 Actinobacteria yjqA Bacteria 2IHVS@201174,3172B@2,arCOG12631@1 NA|NA|NA S Bacterial PH domain MAG.T1.179_01738 714083.JH370377_gene2640 3e-22 110.9 Microbacteriaceae Bacteria 2DNW5@1,2IQ5T@201174,32ZGI@2,4FQ68@85023 NA|NA|NA S Rho termination factor, N-terminal domain MAG.T1.179_01739 935866.JAER01000040_gene512 1.2e-103 382.9 Propionibacteriales Bacteria 2GJU1@201174,4DN4M@85009,COG1028@1,COG1028@2 NA|NA|NA IQ KR domain MAG.T1.179_01741 1957.JODX01000015_gene1376 3e-53 215.3 Actinobacteria cbiM ko:K02007,ko:K16915 ko02010,map02010 M00245,M00246 ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 Bacteria 2GK2U@201174,COG0310@1,COG0310@2 NA|NA|NA P Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import MAG.T1.179_01742 110319.CF8_1033 1.5e-18 99.0 Propionibacteriales cbiL ko:K02007,ko:K02009,ko:K16915 ko02010,map02010 M00245,M00246 ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 iAF987.Gmet_2441 Bacteria 2GRUA@201174,4DS6B@85009,COG0310@1,COG0310@2 NA|NA|NA P PDGLE domain MAG.T1.179_01743 1227352.C173_04326 1.8e-61 243.0 Paenibacillaceae ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1TPBQ@1239,26VNN@186822,4HBXP@91061,COG1131@1,COG1131@2 NA|NA|NA V Bacitracin ABC transporter, ATP-binding protein MAG.T1.179_01744 68170.KL590486_gene9693 7.6e-45 187.6 Pseudonocardiales ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2IING@201174,4E5D6@85010,COG1277@1,COG1277@2 NA|NA|NA S ABC-2 family transporter protein MAG.T1.179_01745 1035308.AQYY01000002_gene263 1.8e-147 528.9 Clostridia ko:K19265 ko00000,ko01000 Bacteria 1TRS0@1239,247RJ@186801,COG0667@1,COG0667@2 NA|NA|NA C aldo keto reductase MAG.T1.179_01746 314278.NB231_10523 3e-156 558.1 Gammaproteobacteria fbp 3.1.3.11,4.1.2.13 ko:K01622 ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00003 R00762,R01068,R01070,R02568,R04780 RC00017,RC00438,RC00439 ko00000,ko00001,ko00002,ko01000 Bacteria 1MXM7@1224,1SKUG@1236,COG1980@1,COG1980@2 NA|NA|NA G Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) MAG.T1.179_01747 1128421.JAGA01000002_gene1272 6.1e-30 139.0 unclassified Bacteria 2.7.7.65 ko:K21088 ko02026,map02026 ko00000,ko00001,ko01000 Bacteria 2NP1A@2323,COG5001@1,COG5001@2 NA|NA|NA T Putative diguanylate phosphodiesterase MAG.T1.179_01748 1172188.KB911825_gene3711 1.4e-38 166.0 Intrasporangiaceae Bacteria 2IMM4@201174,4FGQX@85021,COG3832@1,COG3832@2 NA|NA|NA S Polyketide cyclase / dehydrase and lipid transport MAG.T1.179_01749 1306406.ASHX01000001_gene4395 4.5e-124 451.1 Actinobacteria yhhW_2 ko:K06911,ko:K06975 ko00000 Bacteria 2GM9P@201174,COG1741@1,COG1741@2,COG2388@1,COG2388@2 NA|NA|NA S Belongs to the pirin family MAG.T1.179_01750 710111.FraQA3DRAFT_4644 1.1e-20 106.3 Actinobacteria Bacteria 2GJYB@201174,COG5485@1,COG5485@2 NA|NA|NA S SnoaL-like polyketide cyclase MAG.T1.179_01751 351607.Acel_0144 1.6e-74 286.6 Frankiales Bacteria 2GJV7@201174,4ESVM@85013,COG1609@1,COG1609@2 NA|NA|NA K periplasmic binding protein LacI transcriptional regulator MAG.T1.179_01753 469383.Cwoe_4490 1.4e-29 137.1 Actinobacteria Bacteria 2IR83@201174,COG2199@1,COG2199@2 NA|NA|NA T diguanylate cyclase MAG.T1.179_01754 1206730.BAGA01000093_gene452 1.1e-22 112.8 Nocardiaceae Bacteria 2E7YB@1,2IRTP@201174,332CR@2,4G2XR@85025 NA|NA|NA MAG.T1.179_01755 33876.JNXY01000010_gene2613 9.7e-91 340.5 Micromonosporales ssuA ko:K02051 M00188 ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 iAF987.Gmet_0996 Bacteria 2GK7X@201174,4DBAN@85008,COG0715@1,COG0715@2 NA|NA|NA P ABC transporter, phosphonate, periplasmic substrate-binding protein MAG.T1.179_01756 512565.AMIS_73420 4.2e-72 278.1 Micromonosporales ssuB ko:K02049 M00188 ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 Bacteria 2GN33@201174,4DBHB@85008,COG1116@1,COG1116@2 NA|NA|NA P ATPases associated with a variety of cellular activities MAG.T1.179_01757 1120936.KB907209_gene1439 4.3e-78 298.1 Streptosporangiales ssuC ko:K02050 M00188 ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 Bacteria 2GIWG@201174,4EI0V@85012,COG0600@1,COG0600@2 NA|NA|NA P Binding-protein-dependent transport system inner membrane component MAG.T1.179_01758 479433.Caci_7815 2e-165 588.6 Actinobacteria moeB GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008146,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0016782,GO:0019344,GO:0019752,GO:0020012,GO:0030312,GO:0030682,GO:0042783,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071704,GO:0071944,GO:0075136,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.80,2.8.1.11,3.1.2.6 ko:K01069,ko:K21029,ko:K21147 ko00620,ko04122,map00620,map04122 R01736,R07459,R07461 RC00004,RC00043,RC00137 ko00000,ko00001,ko01000 Bacteria 2GJB6@201174,COG0476@1,COG0476@2,COG0607@1,COG0607@2 NA|NA|NA H The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are MAG.T1.179_01759 479432.Sros_8912 8.9e-25 119.4 Streptosporangiales 2.7.7.80,2.8.1.11 ko:K03636,ko:K21147 ko04122,map04122 R07459,R07461 RC00043 ko00000,ko00001,ko01000 Bacteria 2IQBT@201174,4EKIY@85012,COG1977@1,COG1977@2 NA|NA|NA H ThiS family MAG.T1.179_01760 1123320.KB889748_gene4519 7.9e-156 557.0 Actinobacteria thrC1 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 Bacteria 2GNM0@201174,COG0498@1,COG0498@2 NA|NA|NA E Threonine synthase MAG.T1.179_01761 313589.JNB_13298 1.6e-95 356.3 Intrasporangiaceae 3.2.1.26 ko:K01193 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00801,R00802,R02410,R03635,R03921,R06088 RC00028,RC00077 ko00000,ko00001,ko01000 GH32 Bacteria 2H3S0@201174,4FEDK@85021,COG1621@1,COG1621@2 NA|NA|NA G Glycosyl hydrolase family 32 MAG.T1.179_01762 593907.Celgi_0422 1.8e-31 141.7 Cellulomonadaceae Bacteria 2CUM0@1,2IQG7@201174,32SVJ@2,4F1EW@85016 NA|NA|NA S Protein of unknown function (DUF3263) MAG.T1.179_01763 1048339.KB913029_gene2124 1.2e-82 313.5 Frankiales gpgS 2.4.1.266,2.4.1.268 ko:K13693,ko:K21349 ko00000,ko01000,ko01003 GT81 Bacteria 2GMKV@201174,4ES7J@85013,COG1215@1,COG1215@2 NA|NA|NA M Glycosyltransferase like family 2 MAG.T1.179_01764 136273.GY22_15155 4.2e-26 124.4 Micrococcaceae Bacteria 1W9Y1@1268,2CR5C@1,2IT0H@201174,32SNF@2 NA|NA|NA MAG.T1.179_01765 1385519.N801_08150 1.7e-110 405.6 Intrasporangiaceae groL GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 Bacteria 2GKC9@201174,4FF92@85021,COG0459@1,COG0459@2 NA|NA|NA O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions MAG.T1.179_01766 471852.Tcur_3420 2.8e-81 308.5 Streptosporangiales trmD GO:0000287,GO:0001510,GO:0002939,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050518,GO:0052906,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228,4.6.1.12 ko:K00554,ko:K01770 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R00597,R05637 RC00002,RC00003,RC00334,RC01440 ko00000,ko00001,ko00002,ko01000,ko03016 Bacteria 2GJ1G@201174,4EGB1@85012,COG0336@1,COG0336@2 NA|NA|NA J Belongs to the RNA methyltransferase TrmD family MAG.T1.179_01767 479433.Caci_1514 7.6e-38 163.7 Actinobacteria rimM GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360 ko:K02860 ko00000,ko03009 Bacteria 2GK4I@201174,COG0806@1,COG0806@2 NA|NA|NA J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes MAG.T1.179_01768 1274.HX89_09660 2e-21 108.2 Dermacoccaceae CP_0960 GO:0008150,GO:0040007 ko:K06960 ko00000 Bacteria 1ZW6W@145357,2IQ4C@201174,COG1837@1,COG1837@2 NA|NA|NA S KH domain MAG.T1.179_01769 561175.KB894094_gene1857 1.1e-45 189.5 Streptosporangiales rpsP GO:0000028,GO:0000217,GO:0000400,GO:0003674,GO:0003676,GO:0003677,GO:0003735,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006259,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016787,GO:0016788,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02959 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011,ko03029 Bacteria 2IKU0@201174,4EJRE@85012,COG0228@1,COG0228@2 NA|NA|NA J Ribosomal protein S16 MAG.T1.179_01770 1120917.AQXM01000046_gene30 9.5e-15 85.9 Micrococcaceae ycaQ ko:K09927 ko00000 Bacteria 1W89G@1268,2GJM7@201174,COG3214@1,COG3214@2 NA|NA|NA S Winged helix DNA-binding domain MAG.T1.179_01771 356851.JOAN01000012_gene5167 5.2e-91 341.3 Micromonosporales ycaQ ko:K09927 ko00000 Bacteria 2GJM7@201174,4DA91@85008,COG3214@1,COG3214@2 NA|NA|NA S Winged helix DNA-binding domain MAG.T1.179_01772 446471.Xcel_1165 3.4e-185 654.8 Promicromonosporaceae ffh GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006605,GO:0006612,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0030312,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0040007,GO:0042886,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046907,GO:0048500,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0071944,GO:0072657,GO:0090150,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1990904 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 Bacteria 2GK4R@201174,4F37P@85017,COG0541@1,COG0541@2 NA|NA|NA U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY MAG.T1.179_01773 1380356.JNIK01000018_gene821 5.3e-33 148.7 Frankiales Bacteria 2ICMJ@201174,4ETKK@85013,COG0392@1,COG0392@2 NA|NA|NA S Lysylphosphatidylglycerol synthase TM region MAG.T1.179_01774 105420.BBPO01000125_gene4715 2.9e-15 87.8 Streptacidiphilus Bacteria 2BVHC@1,2IN31@201174,2NMD9@228398,32QVY@2 NA|NA|NA MAG.T1.179_01776 1123320.KB889676_gene2858 1.7e-209 736.1 Actinobacteria glnD 2.7.7.59 ko:K00990 ko02020,map02020 ko00000,ko00001,ko01000 Bacteria 2GMKT@201174,COG2844@1,COG2844@2 NA|NA|NA O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen MAG.T1.179_01777 1449353.JQMQ01000005_gene2028 1.7e-46 191.8 Streptacidiphilus glnB ko:K04751 ko02020,map02020 ko00000,ko00001 Bacteria 2IKN1@201174,2NIJK@228398,COG0347@1,COG0347@2 NA|NA|NA E Nitrogen regulatory protein P-II MAG.T1.179_01778 1306174.JODP01000016_gene7106 1.3e-159 569.7 Actinobacteria amt GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03320 ko00000,ko02000 1.A.11 iNJ661.Rv2920c Bacteria 2GIZK@201174,COG0004@1,COG0004@2 NA|NA|NA P Ammonium transporter MAG.T1.179_01779 591167.Sfla_1718 8.6e-124 450.3 Actinobacteria ftsY GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 Bacteria 2GJQH@201174,COG0552@1,COG0552@2 NA|NA|NA U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) MAG.T1.179_01780 1298863.AUEP01000002_gene1371 0.0 1124.0 Propionibacteriales smc GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 ko:K03529,ko:K19171 ko00000,ko02048,ko03036 Bacteria 2GK93@201174,4DN2T@85009,COG1196@1,COG1196@2 NA|NA|NA D Required for chromosome condensation and partitioning MAG.T1.179_01782 479431.Namu_1888 2.5e-17 94.7 Frankiales acyP GO:0003674,GO:0003824,GO:0003998,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016787,GO:0016817,GO:0016818,GO:0050896 3.6.1.7 ko:K01512 ko00620,ko00627,ko01120,map00620,map00627,map01120 R00317,R01421,R01515 RC00043 ko00000,ko00001,ko01000 iSB619.SA_RS07020,iSBO_1134.SBO_2263,iSF_1195.SF0969,iSFxv_1172.SFxv_1053,iS_1188.S1036 Bacteria 2IQ4M@201174,4ETFK@85013,COG1254@1,COG1254@2 NA|NA|NA C Belongs to the acylphosphatase family MAG.T1.179_01783 1449069.JMLO01000001_gene1725 5.5e-81 307.8 Nocardiaceae fpg GO:0000702,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0008152,GO:0008534,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034039,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 2GJNT@201174,4FV1G@85025,COG0266@1,COG0266@2 NA|NA|NA L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates MAG.T1.179_01784 561175.KB894094_gene1867 4.8e-75 287.7 Streptosporangiales rnc GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 Bacteria 2GKER@201174,4EGGX@85012,COG0571@1,COG0571@2 NA|NA|NA K Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism MAG.T1.179_01785 227882.SAV_2666 5.5e-17 92.8 Actinobacteria rpmF GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904 ko:K02911 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011,ko03029 Bacteria 2GQP3@201174,COG0333@1,COG0333@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL32 family MAG.T1.179_01786 110319.CF8_2880 6.2e-51 207.2 Propionibacteriales yceD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 ko:K07040 ko00000 Bacteria 2GJTS@201174,4DQUU@85009,COG1399@1,COG1399@2 NA|NA|NA S Uncharacterized ACR, COG1399 MAG.T1.179_01787 1463921.JODF01000032_gene2667 1.8e-16 92.8 Actinobacteria Bacteria 2GNBF@201174,COG0711@1,COG0711@2 NA|NA|NA C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) MAG.T1.179_01788 882086.SacxiDRAFT_1033 1.1e-59 236.1 Pseudonocardiales coaD GO:0003674,GO:0003824,GO:0004595,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016043,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0022607,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034214,GO:0034641,GO:0034654,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0055086,GO:0065003,GO:0070566,GO:0071704,GO:0071840,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 2GN1S@201174,4E33S@85010,COG0669@1,COG0669@2 NA|NA|NA H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate MAG.T1.179_01789 1033730.CAHG01000016_gene241 4.3e-42 177.9 Propionibacteriales rsmD GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052913,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.171 ko:K08316 R07234 RC00003 ko00000,ko01000,ko03009 Bacteria 2GQ3G@201174,4DQZ1@85009,COG0742@1,COG0742@2 NA|NA|NA L Conserved hypothetical protein 95 MAG.T1.179_01790 1123322.KB904683_gene4838 3.9e-224 784.6 Actinobacteria recG GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016020,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 ko:K03655 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 2GKA3@201174,COG1200@1,COG1200@2 NA|NA|NA L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) MAG.T1.179_01791 1123320.KB889676_gene2888 1.1e-109 404.1 Actinobacteria dak3 2.7.1.28,2.7.1.29,4.6.1.15 ko:K00863,ko:K07030 ko00051,ko00561,ko00680,ko01100,ko01120,ko01200,ko04622,map00051,map00561,map00680,map01100,map01120,map01200,map04622 M00344 R01011,R01059 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKII@201174,COG1461@1,COG1461@2 NA|NA|NA S Dihydroxyacetone kinase MAG.T1.179_01792 446471.Xcel_2281 4.9e-27 126.3 Promicromonosporaceae rpmB GO:0003674,GO:0003735,GO:0005198 ko:K02902 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GQNU@201174,4F4SP@85017,COG0227@1,COG0227@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL28 family MAG.T1.179_01793 1463887.KL589967_gene6542 3.3e-90 338.6 Actinobacteria thiL GO:0008150,GO:0040007 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv2977c,iYO844.BSU05900 Bacteria 2GP6E@201174,COG0611@1,COG0611@2 NA|NA|NA H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 MAG.T1.179_01794 471857.Svir_09180 4.8e-24 116.7 Pseudonocardiales Bacteria 2IQ4Z@201174,4E5C4@85010,COG1522@1,COG1522@2 NA|NA|NA K AsnC family MAG.T1.179_01795 1120950.KB892741_gene2701 2.7e-18 98.6 Propionibacteriales Bacteria 2CQFE@1,2GRVK@201174,32SM3@2,4DS6W@85009 NA|NA|NA S Protein of unknown function (DUF3515) MAG.T1.179_01796 1229780.BN381_60056 8.1e-31 140.6 Actinobacteria rimJ2 Bacteria 2IS6V@201174,COG1670@1,COG1670@2 NA|NA|NA J Acetyltransferase (GNAT) domain MAG.T1.179_01797 1120950.KB892707_gene4586 3.7e-212 744.6 Propionibacteriales 3.4.19.1 ko:K01303 ko00000,ko01000,ko01002 Bacteria 2GJW4@201174,4DTZJ@85009,COG1506@1,COG1506@2 NA|NA|NA E Dienelactone hydrolase family MAG.T1.179_01798 1048339.KB913029_gene3486 1.4e-121 443.0 Frankiales ddl GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008716,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0016874,GO:0016879,GO:0016881,GO:0044424,GO:0044444,GO:0044464,GO:0050896 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 iAF1260.b0381,iB21_1397.B21_00332,iBWG_1329.BWG_0265,iE2348C_1286.E2348C_0317,iEC042_1314.EC042_0413,iEC55989_1330.EC55989_0386,iECBD_1354.ECBD_3283,iECB_1328.ECB_00328,iECDH10B_1368.ECDH10B_0338,iECDH1ME8569_1439.ECDH1ME8569_0367,iECD_1391.ECD_00328,iECH74115_1262.ECH74115_0453,iECIAI1_1343.ECIAI1_0377,iECIAI39_1322.ECIAI39_0301,iECO103_1326.ECO103_0356,iECO111_1330.ECO111_0411,iECO26_1355.ECO26_0414,iECSE_1348.ECSE_0401,iECSP_1301.ECSP_0441,iECs_1301.ECs0431,iETEC_1333.ETEC_0434,iEcDH1_1363.EcDH1_3227,iEcE24377_1341.EcE24377A_0406,iEcHS_1320.EcHS_A0447,iEcSMS35_1347.EcSMS35_0410,iEcolC_1368.EcolC_3251,iJO1366.b0381,iJR904.b0381,iSF_1195.SF0232,iSFxv_1172.SFxv_0245,iS_1188.S0254,iUMNK88_1353.UMNK88_429,iY75_1357.Y75_RS01965,iZ_1308.Z0477 Bacteria 2GITC@201174,4ERWT@85013,COG1181@1,COG1181@2 NA|NA|NA M Belongs to the D-alanine--D-alanine ligase family MAG.T1.179_01799 1120950.KB892741_gene2699 1e-103 383.6 Propionibacteriales metB 2.5.1.48,4.4.1.8 ko:K01739,ko:K01760 ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017 R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04941,R04944,R04945,R04946 RC00020,RC00056,RC00069,RC00382,RC00420,RC00488,RC00710,RC01245,RC02303,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000 Bacteria 2GMD8@201174,4DPBS@85009,COG0626@1,COG0626@2 NA|NA|NA E Cys/Met metabolism PLP-dependent enzyme MAG.T1.179_01800 397278.JOJN01000003_gene1964 2.1e-46 192.6 Propionibacteriales Bacteria 2I655@201174,4DSYQ@85009,COG3064@1,COG3064@2 NA|NA|NA M Membrane MAG.T1.179_01801 1288079.AUKN01000001_gene4099 1.2e-116 426.4 Actinobacteria gpsA 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 R00842,R00844 RC00029 ko00000,ko00001,ko01000 Bacteria 2GJSD@201174,COG0240@1,COG0240@2 NA|NA|NA I Glycerol-3-phosphate dehydrogenase MAG.T1.179_01802 1123320.KB889676_gene2895 4.1e-64 251.5 Actinobacteria plsC2 Bacteria 2GKVA@201174,COG0204@1,COG0204@2 NA|NA|NA I Acyltransferase MAG.T1.179_01803 471852.Tcur_3460 2e-19 102.8 Streptosporangiales hup GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006355,GO:0006725,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010106,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016043,GO:0019219,GO:0019222,GO:0019725,GO:0030003,GO:0030312,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0040007,GO:0042262,GO:0042592,GO:0042594,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0046916,GO:0048518,GO:0048522,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0060255,GO:0065007,GO:0065008,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090143,GO:0090304,GO:0097100,GO:0097159,GO:0098771,GO:0140110,GO:1901360,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 ko:K03530 ko00000,ko03032,ko03036,ko03400 Bacteria 2GV0M@201174,4EK5F@85012,COG0776@1,COG0776@2 NA|NA|NA L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions MAG.T1.179_01804 1121017.AUFG01000045_gene3633 8e-76 290.0 Intrasporangiaceae leuD GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016020,GO:0016053,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 iNJ661.Rv2987c Bacteria 2GJ8Z@201174,4FE44@85021,COG0066@1,COG0066@2 NA|NA|NA E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate MAG.T1.179_01805 1003195.SCAT_4386 1.2e-221 775.8 Actinobacteria leuC GO:0003674,GO:0003824,GO:0003861,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009316,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 iEcE24377_1341.EcE24377A_0075,iPC815.YPO0531 Bacteria 2GKT7@201174,COG0065@1,COG0065@2 NA|NA|NA E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate MAG.T1.179_01806 1134445.AJJM01000058_gene2331 1.1e-95 356.3 Actinobacteria ltbR Bacteria 2GKB0@201174,COG1414@1,COG1414@2 NA|NA|NA K transcriptional regulator MAG.T1.179_01809 1504319.GM45_4290 4.8e-194 684.1 unclassified Actinobacteria (class) gltX GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 iNJ661.Rv2992c Bacteria 2GJJS@201174,3UW9W@52018,COG0008@1,COG0008@2 NA|NA|NA J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) MAG.T1.179_01810 1317118.ATO8_10023 4.1e-21 108.6 Roseivivax pcpS 6.3.2.14 ko:K02362 ko01053,ko01110,ko01130,map01053,map01110,map01130 R07644 RC00162,RC03046 ko00000,ko00001,ko01000 Bacteria 1MZK2@1224,2UFCE@28211,4KN4K@93682,COG2977@1,COG2977@2 NA|NA|NA Q Belongs to the P-Pant transferase superfamily MAG.T1.179_01811 1448389.BAVQ01000083_gene181 5e-15 86.3 Actinobacteria Bacteria 2GN2G@201174,COG0179@1,COG0179@2 NA|NA|NA Q 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase MAG.T1.179_01812 1123237.Salmuc_03210 1.2e-13 84.3 Alphaproteobacteria Bacteria 1R8UF@1224,2UGWH@28211,COG2931@1,COG2931@2,COG3210@1,COG3210@2 NA|NA|NA QU Parallel beta-helix repeats MAG.T1.179_01813 1121479.AUBS01000002_gene3767 8.6e-110 404.1 Alphaproteobacteria ko:K02022,ko:K12537,ko:K16300 M00328,M00571 ko00000,ko00002,ko02000,ko02044 8.A.1,8.A.1.3.3 Bacteria 1MUI8@1224,2TSP0@28211,COG0845@1,COG0845@2 NA|NA|NA M Type I secretion membrane fusion protein, HlyD MAG.T1.179_01814 1288298.rosmuc_01754 4.4e-178 631.3 Roseovarius prsD ko:K06148,ko:K12536,ko:K16299 ko02010,map02010 M00328,M00571 ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1,3.A.1.110,3.A.1.110.10 Bacteria 1NTI5@1224,2TR17@28211,46NNZ@74030,COG4618@1,COG4618@2 NA|NA|NA V COG4618 ABC-type protease lipase transport system, ATPase and permease components MAG.T1.179_01815 105425.BBPL01000018_gene61 2.4e-178 631.7 Streptacidiphilus clpC ko:K03696 ko01100,map01100 ko00000,ko03110 Bacteria 2GJ77@201174,2NHD1@228398,COG0542@1,COG0542@2 NA|NA|NA O Bacterial TniB protein MAG.T1.179_01816 1122611.KB903943_gene1465 1.5e-06 60.5 Streptosporangiales Bacteria 2E5CN@1,2GM9T@201174,3304R@2,4EJKG@85012 NA|NA|NA MAG.T1.179_01817 1150864.MILUP08_46690 3e-129 468.4 Micromonosporales disA 2.7.7.85 ko:K07067 ko00000,ko01000 Bacteria 2GJ41@201174,4D9EZ@85008,COG1623@1,COG1623@2 NA|NA|NA L Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process MAG.T1.179_01818 570268.ANBB01000033_gene2073 1.6e-141 509.6 Streptosporangiales radA GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 ko:K04485 ko00000,ko03400 Bacteria 2GMQ0@201174,4EG9C@85012,COG1066@1,COG1066@2 NA|NA|NA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function MAG.T1.179_01819 467200.ACFA01000404_gene2616 3.4e-106 391.7 Actinobacteria Bacteria 2GJ6E@201174,COG1082@1,COG1082@2 NA|NA|NA G PFAM Xylose isomerase domain protein TIM barrel MAG.T1.179_01820 931627.MycrhDRAFT_6074 2.6e-67 262.7 Mycobacteriaceae Bacteria 23CKA@1762,2GKPS@201174,COG4850@1,COG4850@2 NA|NA|NA S Uncharacterized conserved protein (DUF2183) MAG.T1.179_01821 1048339.KB913029_gene2309 1.2e-41 177.2 Frankiales ko:K00318 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 R10507 RC00083 ko00000,ko00001,ko01000 Bacteria 2GJTK@201174,4ERCN@85013,COG0506@1,COG0506@2 NA|NA|NA E Proline dehydrogenase MAG.T1.179_01822 1306174.JODP01000006_gene3453 1.4e-70 273.1 Actinobacteria proC GO:0000287,GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019752,GO:0030145,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ7D@201174,COG0345@1,COG0345@2 NA|NA|NA E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline MAG.T1.179_01823 35754.JNYJ01000053_gene6709 5.5e-41 174.5 Micromonosporales trkA ko:K03499 ko00000,ko02000 2.A.38.1,2.A.38.4 Bacteria 2IA09@201174,4DCSC@85008,COG0569@1,COG0569@2 NA|NA|NA P TrkA-C domain MAG.T1.179_01824 1385519.N801_08350 3.7e-102 379.0 Intrasporangiaceae trkH ko:K03498 ko00000,ko02000 2.A.38.1,2.A.38.4 Bacteria 2GKKS@201174,4FG5M@85021,COG0168@1,COG0168@2 NA|NA|NA P Cation transport protein MAG.T1.179_01825 28444.JODQ01000014_gene6728 3.6e-131 474.9 Streptosporangiales acuC ko:K04768 ko00000 iYO844.BSU29710 Bacteria 2GJUH@201174,4EGFY@85012,COG0123@1,COG0123@2 NA|NA|NA BQ Histone deacetylase domain MAG.T1.179_01826 471852.Tcur_4450 4.5e-18 96.7 Streptosporangiales xis Bacteria 2GQGV@201174,4EKJX@85012,COG3311@1,COG3311@2 NA|NA|NA K Helix-turn-helix domain MAG.T1.179_01827 1120950.KB892801_gene1769 1.9e-109 402.5 Propionibacteriales galE2 GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv0501 Bacteria 2GNT1@201174,4DPEE@85009,COG0451@1,COG0451@2 NA|NA|NA GM GDP-mannose 4,6 dehydratase MAG.T1.179_01828 28042.GU90_05920 1.3e-109 402.9 Pseudonocardiales GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 2GJKH@201174,4E0YI@85010,COG0204@1,COG0204@2 NA|NA|NA I Acyltransferase MAG.T1.179_01829 1122182.KB903837_gene3906 1.9e-95 355.9 Micromonosporales ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GKEH@201174,4D8QU@85008,COG1131@1,COG1131@2 NA|NA|NA V AAA domain, putative AbiEii toxin, Type IV TA system MAG.T1.179_01830 1246995.AFR_08775 1.1e-64 253.4 Micromonosporales ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2ID14@201174,4DCGZ@85008,COG1277@1,COG1277@2 NA|NA|NA S ABC-2 family transporter protein MAG.T1.179_01831 44060.JODL01000048_gene1559 2.3e-72 279.3 Actinobacteria serB1 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K21830 ko00000 Bacteria 2GJW9@201174,COG0560@1,COG0560@2 NA|NA|NA E HAD-superfamily subfamily IB hydrolase, TIGR01490 MAG.T1.179_01832 1122182.KB903813_gene2267 1.5e-118 433.3 Micromonosporales 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 Bacteria 2GIUC@201174,4DBR0@85008,COG0318@1,COG0318@2 NA|NA|NA IQ AMP-binding enzyme C-terminal domain MAG.T1.179_01833 1122609.AUGT01000009_gene3024 1.1e-18 99.0 Propionibacteriales Bacteria 2IR0P@201174,4DS21@85009,COG0695@1,COG0695@2 NA|NA|NA O Glutaredoxin-like domain (DUF836) MAG.T1.179_01834 1172179.AUKV01000016_gene2208 5.1e-189 667.5 Actinobacteria Bacteria 2I7MG@201174,COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily MAG.T1.179_01835 1896.JOAU01000002_gene4042 3.1e-75 288.5 Actinobacteria mtnU ko:K11206 ko00000,ko01000 Bacteria 2GMQA@201174,COG0388@1,COG0388@2 NA|NA|NA E Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase MAG.T1.179_01836 1394178.AWOO02000004_gene2330 8.9e-230 803.1 Streptosporangiales acd Bacteria 2GJIB@201174,4EFZX@85012,COG1960@1,COG1960@2 NA|NA|NA I Acyl-CoA dehydrogenase N terminal MAG.T1.179_01837 367299.JOEE01000003_gene2888 1.6e-11 75.9 Intrasporangiaceae Bacteria 2HNF3@201174,4FHWW@85021,COG5652@1,COG5652@2 NA|NA|NA S VanZ like family MAG.T1.179_01838 983917.RGE_30170 1.7e-25 122.9 Bacteria ko:K03830 ko00000,ko01000 Bacteria COG1246@1,COG1246@2 NA|NA|NA E Belongs to the acetyltransferase family. ArgA subfamily MAG.T1.179_01839 1380390.JIAT01000011_gene2386 4.4e-14 84.7 Rubrobacteria Bacteria 2FDZX@1,2IN56@201174,34604@2,4CT9G@84995 NA|NA|NA MAG.T1.179_01840 1205910.B005_2789 3.2e-79 301.6 Streptosporangiales Bacteria 2GIZB@201174,4ENVQ@85012,COG0745@1,COG0745@2 NA|NA|NA T Transcriptional regulatory protein, C terminal MAG.T1.179_01841 675635.Psed_4822 2.6e-88 332.8 Pseudonocardiales Bacteria 2GM17@201174,4DYVE@85010,COG0642@1,COG2205@2 NA|NA|NA T PhoQ Sensor MAG.T1.179_01842 1122933.JNIY01000003_gene63 8e-48 196.8 Actinobacteria ko:K21429 ko00000,ko01002 Bacteria 2GKWI@201174,COG4894@1,COG4894@2 NA|NA|NA S LURP-one-related MAG.T1.179_01843 1121385.AQXW01000002_gene17 1.4e-37 164.5 Bacteria Bacteria COG5555@1,COG5555@2 NA|NA|NA MAG.T1.179_01844 1001240.GY21_10825 3e-91 341.7 Microbacteriaceae glnQ 3.6.3.21 ko:K02028,ko:K10038 ko02010,map02010 M00227,M00236 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3,3.A.1.3.2 Bacteria 2GIZW@201174,4FKHI@85023,COG1126@1,COG1126@2 NA|NA|NA E ATPases associated with a variety of cellular activities MAG.T1.179_01845 1132441.KI519454_gene683 1.8e-142 512.7 Micrococcaceae glnP ko:K02029,ko:K02030 M00236 ko00000,ko00002,ko02000 3.A.1.3 Bacteria 1W836@1268,2GJJ9@201174,COG0765@1,COG0765@2,COG0834@1,COG0834@2 NA|NA|NA P Bacterial extracellular solute-binding proteins, family 3 MAG.T1.179_01848 1463879.JOHP01000007_gene550 2e-07 61.6 Actinobacteria Bacteria 2CC1Y@1,2H69C@201174,3221K@2 NA|NA|NA K Transcription factor WhiB MAG.T1.179_01850 1035308.AQYY01000001_gene2706 3.7e-28 132.5 Peptococcaceae Bacteria 1UHSZ@1239,25H2T@186801,267I3@186807,COG2856@1,COG2856@2 NA|NA|NA E Zn peptidase MAG.T1.179_01852 106370.Francci3_2360 1.6e-07 62.8 Actinobacteria Bacteria 2E3KC@1,2GQQS@201174,32YIM@2 NA|NA|NA S Domain of unknown function (DUF4913) MAG.T1.179_01853 1464048.JNZS01000015_gene3724 2.2e-140 506.1 Micromonosporales Bacteria 2GNQ7@201174,4D94E@85008,COG3505@1,COG3505@2 NA|NA|NA U Type IV secretory pathway, VirD4 components MAG.T1.179_01854 1394178.AWOO02000006_gene3482 1.1e-142 513.5 Streptosporangiales traD ko:K12071 ko00000,ko02044 3.A.7.11.1 Bacteria 2I70J@201174,4EN6Y@85012,COG0433@1,COG0433@2 NA|NA|NA S COG0433 Predicted ATPase MAG.T1.179_01855 1394178.AWOO02000006_gene3481 2e-96 359.8 Streptosporangiales Bacteria 28IPW@1,2HQJM@201174,2Z8PQ@2,4EN0Y@85012 NA|NA|NA MAG.T1.179_01856 1394178.AWOO02000006_gene3480 7.5e-14 85.5 Streptosporangiales Bacteria 2HY5T@201174,4EPNA@85012,COG3266@1,COG3266@2 NA|NA|NA S domain, Protein MAG.T1.179_01858 1463934.JOCF01000098_gene4313 1.7e-16 92.0 Actinobacteria Bacteria 28U93@1,2GXR6@201174,2ZGEN@2 NA|NA|NA MAG.T1.179_01860 1429046.RR21198_1046 1.8e-07 63.5 Actinobacteria Bacteria 2GYB1@201174,COG1396@1,COG1396@2 NA|NA|NA K Helix-turn-helix XRE-family like proteins MAG.T1.179_01861 1048339.KB913029_gene158 3.6e-39 169.1 Frankiales Bacteria 2IHBR@201174,4EW9H@85013,COG0741@1,COG0741@2,COG3103@1,COG4991@2 NA|NA|NA MT Transglycosylase SLT domain MAG.T1.179_01863 356851.JOAN01000015_gene2410 1.6e-113 416.4 Micromonosporales ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GIRW@201174,4D8P2@85008,COG0577@1,COG0577@2 NA|NA|NA V COG0577 ABC-type antimicrobial peptide transport system, permease component MAG.T1.179_01864 1214101.BN159_2089 2.7e-70 271.9 Actinobacteria ko:K02003 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GK3I@201174,COG1136@1,COG1136@2 NA|NA|NA V ABC transporter MAG.T1.179_01865 1214101.BN159_2088 2.9e-60 239.2 Actinobacteria Bacteria 2I9HW@201174,COG3409@1,COG3409@2 NA|NA|NA M Putative peptidoglycan binding domain MAG.T1.179_01866 356851.JOAN01000015_gene2407 1.8e-15 89.4 Micromonosporales Bacteria 2EBG5@1,2GRUT@201174,335GQ@2,4DFPV@85008 NA|NA|NA MAG.T1.179_01867 479431.Namu_3385 2.2e-74 285.8 Frankiales ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GMJD@201174,4EV32@85013,COG1277@1,COG1277@2 NA|NA|NA S ABC-2 family transporter protein MAG.T1.179_01868 526225.Gobs_2016 2.1e-118 432.2 Frankiales ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GJDP@201174,4EUYH@85013,COG1131@1,COG1131@2 NA|NA|NA V PFAM ABC transporter related MAG.T1.179_01869 1380347.JNII01000005_gene2844 2.3e-79 302.0 Frankiales Bacteria 2GJ46@201174,4ESF3@85013,COG2197@1,COG2197@2 NA|NA|NA T Two component transcriptional regulator, LuxR family MAG.T1.179_01870 570268.ANBB01000050_gene4013 1.9e-56 226.5 Actinobacteria Bacteria 2GKV2@201174,COG4585@1,COG4585@2 NA|NA|NA T Histidine kinase MAG.T1.179_01871 298655.KI912266_gene5611 1.4e-74 286.6 Frankiales ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GN8P@201174,4EV93@85013,COG1131@1,COG1131@2 NA|NA|NA V ABC transporter MAG.T1.179_01872 471853.Bcav_0362 1.2e-18 100.5 Actinobacteria ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2IRIX@201174,COG1277@1,COG1277@2 NA|NA|NA S ABC-type transport system involved in multi-copper enzyme maturation permease component MAG.T1.179_01873 1121946.AUAX01000004_gene744 7.2e-17 94.4 Micromonosporales Bacteria 2GKW3@201174,4DDW4@85008,COG1309@1,COG1309@2 NA|NA|NA K Bacterial regulatory proteins, tetR family MAG.T1.179_01874 479433.Caci_6678 4.5e-134 485.0 Actinobacteria Bacteria 2GIUM@201174,COG0477@1,COG0477@2 NA|NA|NA EGP Major facilitator superfamily MAG.T1.179_01875 1095767.CAHD01000200_gene2348 8.8e-41 173.7 Cellulomonadaceae Bacteria 2GP92@201174,4F2PC@85016,COG1309@1,COG1309@2 NA|NA|NA K Bacterial regulatory proteins, tetR family MAG.T1.179_01876 47839.CCAU010000011_gene5295 1.7e-20 106.3 Mycobacteriaceae Bacteria 2391H@1762,2IMN5@201174,COG1309@1,COG1309@2 NA|NA|NA K WHG domain MAG.T1.179_01877 1108045.GORHZ_053_00570 4.5e-64 251.5 Gordoniaceae vdlC Bacteria 2IIVW@201174,4GE8H@85026,COG0300@1,COG0300@2 NA|NA|NA S NAD(P)H-binding MAG.T1.179_01879 1254432.SCE1572_28415 1.6e-33 149.4 Proteobacteria betI9 Bacteria 1N6TK@1224,COG1309@1,COG1309@2 NA|NA|NA K Transcriptional regulator MAG.T1.179_01880 318424.EU78_15100 2.3e-22 112.1 Bacteria 2.3.1.82 ko:K18815 br01600,ko00000,ko01000,ko01504 Bacteria COG0454@1,COG0456@2 NA|NA|NA K acetyltransferase MAG.T1.179_01881 1094980.Mpsy_0339 3e-14 84.7 Methanomicrobia ko:K10716 ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 Archaea 2NA44@224756,2Y1ZP@28890,COG1226@1,arCOG01958@2157 NA|NA|NA P Ion channel MAG.T1.179_01885 1121017.AUFG01000027_gene526 8.1e-24 119.0 Actinobacteria Bacteria 2GPWU@201174,COG0323@1,COG0323@2 NA|NA|NA L PFAM Relaxase mobilization nuclease family protein MAG.T1.179_01888 591159.ACEZ01000142_gene247 7.3e-50 204.1 Actinobacteria Bacteria 2GJHA@201174,COG0464@1,COG0464@2 NA|NA|NA O Protein of unknown function (DUF3631) MAG.T1.179_01889 941449.dsx2_2388 1.4e-24 120.2 Desulfovibrionales Bacteria 1R4GY@1224,2DPHF@1,2M8FU@213115,2WZY2@28221,33237@2,435JT@68525 NA|NA|NA S L-2-amino-thiazoline-4-carboxylic acid hydrolase MAG.T1.179_01890 1043493.BBLU01000002_gene1838 9.3e-37 160.6 Bacteria ko:K16129 ko01054,map01054 ko00000,ko00001,ko01008 Bacteria COG0500@1,COG2226@2 NA|NA|NA Q methyltransferase MAG.T1.179_01892 1210046.B277_10696 3.6e-41 173.7 Intrasporangiaceae yoeB ko:K19158 ko00000,ko01000,ko02048 Bacteria 2IQAJ@201174,4FHKN@85021,COG4115@1,COG4115@2 NA|NA|NA S YoeB-like toxin of bacterial type II toxin-antitoxin system MAG.T1.179_01893 1184607.AUCHE_20_00230 6.6e-32 142.9 Actinobacteria 2.3.1.15 ko:K08591,ko:K19159 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004,ko02048 Bacteria 2IQ6H@201174,COG2161@1,COG2161@2 NA|NA|NA D Antitoxin component of a toxin-antitoxin (TA) module MAG.T1.179_01894 1122138.AQUZ01000074_gene7343 2.3e-42 178.3 Propionibacteriales Bacteria 2DWJQ@1,2IMTZ@201174,340PJ@2,4DV4I@85009 NA|NA|NA MAG.T1.179_01895 1122138.AQUZ01000074_gene7344 1.2e-68 266.2 Propionibacteriales Bacteria 2IJS1@201174,4DUDM@85009,COG1708@1,COG1708@2 NA|NA|NA S Nucleotidyltransferase domain MAG.T1.179_01896 1416759.AYMR01000011_gene320 1.7e-85 323.2 Actinobacteria Bacteria 2I7P1@201174,COG0457@1,COG0457@2 NA|NA|NA S Domain of unknown function (DUF4037) MAG.T1.179_01897 754252.PFREUD_01970 1e-161 576.6 Propionibacteriales Bacteria 2GN3K@201174,4DPZD@85009,COG3177@1,COG3177@2 NA|NA|NA S Fic/DOC family MAG.T1.179_01898 644548.SCNU_00065 6.9e-23 114.4 Gordoniaceae Bacteria 2GMMI@201174,4GD92@85026,COG0582@1,COG0582@2 NA|NA|NA L Belongs to the 'phage' integrase family MAG.T1.179_01899 367299.JOEE01000004_gene1254 1.1e-20 107.5 Intrasporangiaceae Bacteria 2CD8B@1,2II9F@201174,30VJG@2,4FI3H@85021 NA|NA|NA MAG.T1.179_01900 710696.Intca_0674 9.3e-45 186.8 Intrasporangiaceae ko:K03088 ko00000,ko03021 Bacteria 2IRNG@201174,4FH7C@85021,COG1595@1,COG1595@2 NA|NA|NA K Belongs to the sigma-70 factor family MAG.T1.179_01901 1313172.YM304_40470 6.1e-10 71.6 Actinobacteria ko:K11748 ko00000,ko02000 2.A.37.1.2 Bacteria 2DDQ5@1,2HDNV@201174,2ZIVU@2 NA|NA|NA MAG.T1.179_01902 882083.SacmaDRAFT_3092 9e-143 513.5 Pseudonocardiales aslB GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0019538,GO:0043170,GO:0044238,GO:0051604,GO:0071704,GO:1901564 ko:K06871 ko00000 Bacteria 2GMTV@201174,4E1AJ@85010,COG0641@1,COG0641@2 NA|NA|NA C Radical SAM superfamily MAG.T1.179_01903 1380356.JNIK01000015_gene2367 8.8e-299 1032.7 Frankiales 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 Bacteria 2GJ8H@201174,4ETR9@85013,COG3119@1,COG3119@2 NA|NA|NA P Sulfatase MAG.T1.179_01904 1033730.CAHG01000016_gene350 3.7e-81 309.3 Propionibacteriales ko:K03321 ko00000,ko02000 2.A.53.3 Bacteria 2GJCB@201174,4DT31@85009,COG0659@1,COG0659@2 NA|NA|NA P Sulfate permease family MAG.T1.179_01905 1517681.HW45_14665 1e-58 233.0 Vibrionales hpt 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 Bacteria 1QJNX@1224,1THPU@1236,1XX3B@135623,COG0634@1,COG0634@2 NA|NA|NA F Phosphoribosyl transferase domain MAG.T1.179_01910 28444.JODQ01000006_gene351 3.5e-17 95.1 Streptosporangiales ko:K03088 ko00000,ko03021 Bacteria 2IRNG@201174,4EJSS@85012,COG1595@1,COG1595@2 NA|NA|NA K Sigma-70, region 4 MAG.T1.179_01911 298654.FraEuI1c_2160 2e-69 269.2 Frankiales ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GIVW@201174,4ERFD@85013,COG0842@1,COG0842@2 NA|NA|NA V PFAM ABC-2 type transporter MAG.T1.179_01912 208439.AJAP_13005 3.1e-101 375.2 Pseudonocardiales ko:K01990,ko:K18232 ko02010,map02010 M00254,M00634 ko00000,ko00001,ko00002,ko01504,ko02000 3.A.1,3.A.1.105.2 Bacteria 2GIY8@201174,4DXJX@85010,COG1131@1,COG1131@2 NA|NA|NA V Part of the ABC transporter complex DrrAB involved in daunorubicin and doxorubicin resistance. Responsible for energy coupling to the transport system. Binds ATP or GTP MAG.T1.179_01913 1463825.JNXC01000027_gene3228 3.1e-31 142.5 Pseudonocardiales Bacteria 2GJZC@201174,4E0KS@85010,COG3595@1,COG3595@2 NA|NA|NA S Putative adhesin MAG.T1.179_01914 1125971.ASJB01000074_gene74 1.3e-35 156.4 Pseudonocardiales Bacteria 2IKXB@201174,4E3FU@85010,COG4226@1,COG4226@2 NA|NA|NA S protein encoded in hypervariable junctions of pilus gene clusters MAG.T1.179_01916 1713.JOFV01000003_gene1528 1.9e-129 469.2 Cellulomonadaceae hemD 2.1.1.107,4.2.1.75 ko:K01719,ko:K13542 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165,R03194 RC00003,RC00871,RC01861 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKMM@201174,4F0R3@85016,COG0745@1,COG0745@2,COG1587@1,COG1587@2 NA|NA|NA HK PFAM Uroporphyrinogen III synthase HEM4 MAG.T1.179_01917 1380354.JIAN01000005_gene1238 1.4e-75 289.7 Cellulomonadaceae cysG GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009628,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.13.11.79,1.3.1.76,2.1.1.107,2.1.1.131,3.7.1.12,4.99.1.4 ko:K02302,ko:K02303,ko:K02304,ko:K04719,ko:K13541 ko00740,ko00860,ko01100,ko01110,ko01120,map00740,map00860,map01100,map01110,map01120 M00121 R02864,R03194,R03947,R05180,R05809,R07772,R09083 RC00003,RC00435,RC00871,RC01012,RC01034,RC01293,RC01545,RC02097,RC02413,RC03471 ko00000,ko00001,ko00002,ko01000 iECIAI1_1343.ECIAI1_3507,iECSE_1348.ECSE_3630,iEcE24377_1341.EcE24377A_3838,iJN746.PP_3999,iPC815.YPO0158 Bacteria 2GK3B@201174,4F260@85016,COG0007@1,COG0007@2,COG1648@1,COG1648@2 NA|NA|NA H PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase MAG.T1.179_01918 1385519.N801_03455 8.5e-31 139.8 Intrasporangiaceae nirD GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006091,GO:0008150,GO:0008152,GO:0008942,GO:0009061,GO:0009344,GO:0009987,GO:0015980,GO:0016491,GO:0016661,GO:0032991,GO:0044237,GO:0044424,GO:0044464,GO:0045333,GO:0046857,GO:0055114,GO:0098809 1.7.1.15 ko:K00362,ko:K00363,ko:K05710 ko00360,ko00910,ko01120,ko01220,map00360,map00910,map01120,map01220 M00530,M00545 R00787,R06782,R06783 RC00098,RC00176 br01602,ko00000,ko00001,ko00002,ko01000 iEC55989_1330.EC55989_3772 Bacteria 2IQM4@201174,4FHUA@85021,COG2146@1,COG2146@2 NA|NA|NA P Rieske-like [2Fe-2S] domain MAG.T1.179_01919 1385518.N798_06760 0.0 1272.7 Intrasporangiaceae nirB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006091,GO:0008150,GO:0008152,GO:0008942,GO:0009061,GO:0009344,GO:0009987,GO:0015980,GO:0016491,GO:0016661,GO:0020037,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044464,GO:0045333,GO:0046857,GO:0046906,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0051536,GO:0051540,GO:0055114,GO:0097159,GO:0098809,GO:1901265,GO:1901363 1.7.1.15 ko:K00362 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 iECIAI39_1322.ECIAI39_3849 Bacteria 2GJ3U@201174,4FF81@85021,COG1251@1,COG1251@2 NA|NA|NA C Belongs to the nitrite and sulfite reductase 4Fe-4S domain family MAG.T1.179_01920 935839.JAGJ01000004_gene1928 7.9e-126 457.6 Promicromonosporaceae nasC 1.7.1.15 ko:K00360,ko:K00362 ko00910,ko01120,map00910,map01120 M00530,M00531 R00787,R00798 RC00176,RC02812 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ3U@201174,4F3YI@85017,COG1251@1,COG1251@2 NA|NA|NA C BFD-like [2Fe-2S] binding domain MAG.T1.179_01921 471853.Bcav_2801 7.7e-294 1016.1 Actinobacteria nasC ko:K00372 ko00910,ko01120,map00910,map01120 M00531 R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000 Bacteria 2HC9H@201174,COG3383@1,COG3383@2 NA|NA|NA C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family MAG.T1.179_01922 590998.Celf_1257 1.4e-171 609.4 Cellulomonadaceae narU ko:K02575 ko00910,map00910 M00615 ko00000,ko00001,ko00002,ko02000 2.A.1.8 iNJ661.Rv0267 Bacteria 2GJ1I@201174,4F0H3@85016,COG2223@1,COG2223@2 NA|NA|NA P PFAM major facilitator superfamily MFS_1 MAG.T1.179_01923 649349.Lbys_1178 9.8e-37 159.8 Cytophagia mgsA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0008150,GO:0008152,GO:0008929,GO:0009058,GO:0009438,GO:0009987,GO:0016829,GO:0016835,GO:0016838,GO:0019242,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0071704,GO:1901576 4.2.3.3 ko:K01734 ko00640,ko01120,map00640,map01120 R01016 RC00424 ko00000,ko00001,ko01000 iECUMN_1333.ECUMN_1153,iYL1228.KPN_00992 Bacteria 47PW5@768503,4NQJ9@976,COG1803@1,COG1803@2 NA|NA|NA G MGS-like domain MAG.T1.179_01924 1404245.CGLY_03165 7.4e-29 134.0 Corynebacteriaceae Bacteria 22JPX@1653,2GKFS@201174,COG0745@1,COG0745@2 NA|NA|NA T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain MAG.T1.179_01925 313589.JNB_07719 9.1e-94 350.1 Intrasporangiaceae fmt2 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 Bacteria 2GKJH@201174,4FEFV@85021,COG1611@1,COG1611@2 NA|NA|NA S Belongs to the LOG family MAG.T1.179_01926 1906.SFRA_16445 3.4e-25 122.1 Actinobacteria 2.7.7.87 ko:K07566 R10463 RC00745 ko00000,ko01000,ko03009,ko03016 Bacteria 2IKIN@201174,COG4902@1,COG4902@2 NA|NA|NA S Uncharacterized protein domain (DUF2202) MAG.T1.179_01927 1035308.AQYY01000002_gene880 2.7e-82 312.8 Clostridia 2.7.13.3 ko:K02484,ko:K07768 ko02020,map02020 M00443 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 1TQ1H@1239,247VG@186801,COG5002@1,COG5002@2 NA|NA|NA T Histidine kinase MAG.T1.179_01928 1035308.AQYY01000002_gene879 1.6e-74 285.8 Clostridia Bacteria 1TS81@1239,248XH@186801,COG0745@1,COG0745@2 NA|NA|NA T response regulator receiver MAG.T1.179_01930 1035308.AQYY01000001_gene3237 1.1e-195 689.5 Clostridia 1.8.5.4 ko:K17218 ko00920,map00920 R10152 RC03155 ko00000,ko00001,ko01000 Bacteria 1V11U@1239,25BW0@186801,COG0446@1,COG0446@2 NA|NA|NA S Pyridine nucleotide-disulphide oxidoreductase MAG.T1.179_01931 1304865.JAGF01000001_gene3278 0.0 1120.1 Cellulomonadaceae cdr ko:K04085 ko04122,map04122 ko00000,ko00001,ko01000,ko03016 Bacteria 2H7WY@201174,4F10M@85016,COG0446@1,COG0446@2,COG0607@1,COG0607@2,COG2210@1,COG2210@2 NA|NA|NA P PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase MAG.T1.179_01932 1051632.TPY_2536 4.6e-23 114.0 Firmicutes Bacteria 1W45F@1239,COG1433@1,COG1433@2 NA|NA|NA S Dinitrogenase iron-molybdenum cofactor MAG.T1.179_01933 1035308.AQYY01000002_gene111 1.7e-58 233.4 Peptococcaceae Bacteria 1V0ES@1239,24Q6Z@186801,26717@186807,COG1275@1,COG1275@2 NA|NA|NA P Voltage-dependent anion channel MAG.T1.179_01934 446469.Sked_03560 1.4e-118 433.3 Actinobacteria phoA 3.1.3.1 ko:K01077 ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020 M00126 R02135,R04620 RC00017 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 Bacteria 2GM8A@201174,COG1785@1,COG1785@2 NA|NA|NA P Belongs to the alkaline phosphatase family MAG.T1.179_01935 1064537.AGSO01000003_gene1096 8.1e-29 134.4 Dermabacteraceae ko:K07090 ko00000 Bacteria 2I5VT@201174,4FCQ5@85020,COG0730@1,COG0730@2 NA|NA|NA S Sulfite exporter TauE/SafE MAG.T1.179_01936 55952.BU52_25740 9.3e-134 483.8 Actinobacteria 3.1.2.6 ko:K01069 ko00620,map00620 R01736 RC00004,RC00137 ko00000,ko00001,ko01000 Bacteria 2GN50@201174,COG0491@1,COG0491@2,COG0607@1,COG0607@2 NA|NA|NA P PFAM beta-lactamase domain protein MAG.T1.179_01937 1123309.AQYB01000031_gene361 3.7e-19 100.9 Bacilli pspE Bacteria 1VES3@1239,4HNRE@91061,COG0607@1,COG0607@2 NA|NA|NA P COG0607 Rhodanese-related sulfurtransferase MAG.T1.179_01940 1121946.AUAX01000005_gene5377 1.2e-207 729.6 Micromonosporales csdA 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 Bacteria 2GP7W@201174,4DAKS@85008,COG0520@1,COG0520@2 NA|NA|NA E Aminotransferase class-V MAG.T1.179_01941 1184607.AUCHE_05_03520 2.5e-34 152.1 Actinobacteria mauF 2.7.11.1 ko:K03466,ko:K06196,ko:K12132 ko00000,ko01000,ko01001,ko02000,ko03036 3.A.12,5.A.1.2 Bacteria 2IMP9@201174,COG0785@1,COG0785@2 NA|NA|NA O Cytochrome C biogenesis protein MAG.T1.179_01942 1122622.ATWJ01000002_gene818 1.6e-24 119.0 Intrasporangiaceae ko:K03972 ko00000 Bacteria 2GR81@201174,4FHT9@85021,COG0607@1,COG0607@2 NA|NA|NA P Rhodanese Homology Domain MAG.T1.179_01943 1172188.KB911821_gene1461 1.3e-187 663.3 Intrasporangiaceae Bacteria 2GM2C@201174,4FIB5@85021,COG2898@1,COG2898@2 NA|NA|NA S Uncharacterised conserved protein (DUF2156) MAG.T1.179_01944 1484479.DI14_14505 9.3e-78 297.0 Bacilli Bacteria 1UFDJ@1239,4HDIH@91061,COG0561@1,COG0561@2 NA|NA|NA G hydrolase MAG.T1.179_01945 1304865.JAGF01000001_gene2261 1.2e-224 785.8 Actinobacteria bglH 3.2.1.86 ko:K01223 ko00010,ko00500,map00010,map00500 R00839,R05133,R05134 RC00049,RC00171,RC00714 ko00000,ko00001,ko01000 GT1 Bacteria 2GJAF@201174,COG2723@1,COG2723@2 NA|NA|NA G Belongs to the glycosyl hydrolase 1 family MAG.T1.179_01946 867903.ThesuDRAFT_01213 7.1e-129 467.6 Clostridiales incertae sedis fumC 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 Bacteria 1UHPH@1239,25F3I@186801,3WCCI@538999,COG0114@1,COG0114@2 NA|NA|NA C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate MAG.T1.179_01947 1032480.MLP_14960 1.7e-67 262.3 Propionibacteriales def 3.5.1.88 ko:K01462 ko00000,ko01000 Bacteria 2GJ87@201174,4DQAV@85009,COG0242@1,COG0242@2 NA|NA|NA J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions MAG.T1.179_01948 526225.Gobs_4775 8.9e-64 250.8 Frankiales rsgA 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 Bacteria 2GMDX@201174,4EU3D@85013,COG1162@1,COG1162@2 NA|NA|NA S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit MAG.T1.179_01950 935866.JAER01000027_gene4225 1.5e-41 176.0 Propionibacteriales Bacteria 2IME3@201174,4DWV7@85009,COG2716@1,COG2716@2 NA|NA|NA E ACT domain MAG.T1.179_01951 1894.JOER01000022_gene3926 6.1e-96 358.2 Actinobacteria 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 Bacteria 2GKPZ@201174,COG0154@1,COG0154@2 NA|NA|NA J Belongs to the amidase family MAG.T1.179_01952 420324.KI912044_gene3963 8.2e-28 131.0 Methylobacteriaceae ko:K06889 ko00000 Bacteria 1JTW5@119045,1NXZW@1224,2TSEE@28211,COG1073@1,COG1073@2 NA|NA|NA S Uncharacterised protein family (UPF0227) MAG.T1.179_01953 103733.JNYO01000021_gene6755 6.9e-31 141.7 Actinobacteria Bacteria 2H3FK@201174,COG2199@1,COG3706@2,COG5001@1,COG5001@2 NA|NA|NA T diguanylate cyclase MAG.T1.179_01954 497321.C664_13322 2.8e-81 308.1 Rhodocyclales pfpI 3.5.1.124 ko:K05520 ko00000,ko01000,ko01002 Bacteria 1MY0C@1224,2KV2H@206389,2VM0T@28216,COG0693@1,COG0693@2 NA|NA|NA S DJ-1/PfpI family MAG.T1.179_01955 1278078.G419_24269 9.9e-63 246.5 Nocardiaceae Bacteria 2GNR0@201174,4FXM7@85025,COG2119@1,COG2119@2 NA|NA|NA S Uncharacterized protein family UPF0016 MAG.T1.179_01956 1108045.GORHZ_141_00770 2.6e-13 80.9 Actinobacteria Bacteria 2EMYX@1,2GZ6D@201174,33FM2@2 NA|NA|NA MAG.T1.179_01957 1463901.JOIY01000037_gene7073 7.1e-52 211.1 Actinobacteria Bacteria 2H9P8@201174,COG0697@1,COG0697@2 NA|NA|NA EG spore germination MAG.T1.179_01958 1304876.AZVC01000001_gene1260 2.8e-27 128.3 Micrococcaceae Bacteria 1WA7S@1268,2IQEW@201174,COG1725@1,COG1725@2 NA|NA|NA K helix_turn_helix gluconate operon transcriptional repressor MAG.T1.179_01959 446466.Cfla_1316 2.4e-20 106.3 Actinobacteria Bacteria 2ERYQ@1,2GXQP@201174,33JHV@2 NA|NA|NA MAG.T1.179_01961 446468.Ndas_2917 6.3e-19 100.1 Streptosporangiales ko:K06975 ko00000 Bacteria 2GQNP@201174,4EKDK@85012,COG2388@1,COG2388@2 NA|NA|NA S GCN5-related N-acetyl-transferase MAG.T1.179_01962 335543.Sfum_1471 6.5e-237 827.0 Syntrophobacterales glgX 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 ko00000,ko00001,ko00002,ko01000 CBM48,GH13 Bacteria 1MU19@1224,2MQ9F@213462,2WKFS@28221,42P3J@68525,COG1523@1,COG1523@2 NA|NA|NA G Belongs to the glycosyl hydrolase 13 family MAG.T1.179_01964 1283283.ATXA01000008_gene3121 1.3e-11 75.9 Actinobacteria rnhA 3.1.26.4,4.1.1.44 ko:K01607,ko:K03469 ko00362,ko01100,ko01120,ko01220,ko03030,map00362,map01100,map01120,map01220,map03030 R03470 RC00938 ko00000,ko00001,ko01000,ko03032 Bacteria 2IM93@201174,COG0599@1,COG0599@2 NA|NA|NA S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity MAG.T1.179_01965 478801.Ksed_14950 9e-45 186.8 Dermacoccaceae merR2 Bacteria 1ZVW1@145357,2GM67@201174,COG0789@1,COG0789@2 NA|NA|NA K helix_turn_helix, mercury resistance MAG.T1.179_01966 1123320.KB889679_gene2403 1e-43 182.6 Actinobacteria yitW ko:K02612 ko00360,ko01120,map00360,map01120 R09838 RC02690 ko00000,ko00001 Bacteria 2IKUH@201174,COG2151@1,COG2151@2 NA|NA|NA J metal-sulfur cluster biosynthetic enzyme MAG.T1.179_01967 471852.Tcur_2229 5.2e-51 207.2 Streptosporangiales iscU ko:K04488 ko00000 Bacteria 2IHY9@201174,4EIUC@85012,COG0822@1,COG0822@2 NA|NA|NA C NifU-like N terminal domain MAG.T1.179_01968 471852.Tcur_2228 5e-163 580.9 Streptosporangiales sufS GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 Bacteria 2GIVK@201174,4EHYF@85012,COG0520@1,COG0520@2 NA|NA|NA E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine MAG.T1.179_01969 1155714.KB891988_gene2109 5.3e-112 410.6 Actinobacteria sufC ko:K09013 ko00000,ko02000 Bacteria 2GKB7@201174,COG0396@1,COG0396@2 NA|NA|NA O FeS assembly ATPase SufC MAG.T1.179_01970 1944.JOAZ01000005_gene1991 4.5e-30 137.1 Streptomyces griseus group hcaC ko:K05710 ko00360,ko01120,ko01220,map00360,map01120,map01220 M00545 R06782,R06783 RC00098 br01602,ko00000,ko00001,ko00002 Bacteria 2IQK7@201174,41AUI@629295,COG2146@1,COG2146@2 NA|NA|NA P Rieske-like [2Fe-2S] domain MAG.T1.179_01972 1048339.KB913029_gene4338 1.5e-245 855.1 Frankiales sufB ko:K07033,ko:K09014 ko00000 Bacteria 2GKCZ@201174,4ERKY@85013,COG0719@1,COG0719@2 NA|NA|NA O TIGRFAM FeS assembly protein SufB MAG.T1.179_01973 479435.Kfla_3277 1.4e-58 233.0 Propionibacteriales sufR Bacteria 2GN8W@201174,4DQCB@85009,COG2345@1,COG2345@2 NA|NA|NA K Transcriptional regulator MAG.T1.179_01974 1137269.AZWL01000008_gene4672 1.1e-92 346.7 Actinobacteria drrA_2 ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GJBF@201174,COG1131@1,COG1131@2 NA|NA|NA V ABC transporter MAG.T1.179_01975 1394178.AWOO02000020_gene7495 2.9e-49 202.2 Streptosporangiales ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GN6S@201174,4EI28@85012,COG0842@1,COG0842@2 NA|NA|NA V ABC-2 family transporter protein MAG.T1.179_01976 1121385.AQXW01000004_gene1221 1.1e-66 260.4 Dermacoccaceae ctaA ko:K02259 ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714 M00154 R07412 RC00769 ko00000,ko00001,ko00002,ko03029 3.D.4.4 Bacteria 1ZVU4@145357,2GJQX@201174,COG1612@1,COG1612@2 NA|NA|NA O Cytochrome oxidase assembly protein MAG.T1.179_01978 512565.AMIS_40330 5.6e-81 307.4 Micromonosporales Bacteria 2GMVN@201174,4D8W6@85008,COG0745@1,COG0745@2 NA|NA|NA T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain MAG.T1.179_01979 219305.MCAG_00019 5.9e-74 285.0 Micromonosporales 2.7.13.3 ko:K02484,ko:K07653 ko02020,map02020 M00460 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 2I3U8@201174,4D9HY@85008,COG5002@1,COG5002@2 NA|NA|NA T His Kinase A (phosphoacceptor) domain MAG.T1.179_01980 710696.Intca_1695 6.2e-88 330.9 Intrasporangiaceae ctaB GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 Bacteria 2GJMY@201174,4FEY1@85021,COG0109@1,COG0109@2 NA|NA|NA O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group MAG.T1.179_01981 452652.KSE_55490 7.6e-254 883.2 Kitasatospora tkt 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ1K@201174,2M2DG@2063,COG0021@1,COG0021@2 NA|NA|NA G Transketolase, thiamine diphosphate binding domain MAG.T1.179_01982 100226.SCO1943 1.1e-42 179.1 Actinobacteria rbpA Bacteria 2CNY9@1,2IKKZ@201174,31GEE@2 NA|NA|NA K Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters MAG.T1.179_01983 1298863.AUEP01000005_gene2451 9.3e-17 92.4 Propionibacteriales secG GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 Bacteria 2GR31@201174,4DS3V@85009,COG1314@1,COG1314@2 NA|NA|NA U Preprotein translocase SecG subunit MAG.T1.179_01984 500153.JOEK01000014_gene5647 9.2e-104 383.3 Actinobacteria tpiA GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 2.7.2.3,5.3.1.1 ko:K00927,ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01015,R01512 RC00002,RC00043,RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GJXZ@201174,COG0149@1,COG0149@2 NA|NA|NA G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) MAG.T1.179_01985 446471.Xcel_1549 2.9e-136 491.9 Promicromonosporaceae pgk GO:0003674,GO:0003824,GO:0004618,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.2.3,5.3.1.1 ko:K00927,ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01015,R01512 RC00002,RC00043,RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GJC6@201174,4F49B@85017,COG0126@1,COG0126@2 NA|NA|NA G Phosphoglycerate kinase MAG.T1.179_01986 1123322.KB904653_gene803 2.2e-139 501.9 Actinobacteria whiA GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0043937,GO:0044464,GO:0050789,GO:0050793,GO:0065007,GO:0071944 ko:K09762 ko00000 Bacteria 2GJZU@201174,COG1481@1,COG1481@2 NA|NA|NA K May be required for sporulation MAG.T1.179_01987 1380346.JNIH01000005_gene3152 6.8e-91 340.9 Actinobacteria ybhK Bacteria 2GJBW@201174,COG0391@1,COG0391@2 NA|NA|NA S Required for morphogenesis under gluconeogenic growth conditions MAG.T1.179_01988 100226.SCO1952 5.2e-95 354.4 Actinobacteria rapZ GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363 ko:K06958 ko00000,ko03019 Bacteria 2GMWB@201174,COG1660@1,COG1660@2 NA|NA|NA S Displays ATPase and GTPase activities MAG.T1.179_01989 105422.BBPM01000004_gene5337 1.7e-223 782.3 Streptacidiphilus uvrC GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016787,GO:0016788,GO:0030312,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1902494,GO:1905347,GO:1905348,GO:1990391 ko:K03703 ko03420,map03420 ko00000,ko00001,ko03400 Bacteria 2GIS4@201174,2NEJF@228398,COG0322@1,COG0322@2 NA|NA|NA L GIY-YIG type nucleases (URI domain) MAG.T1.179_01990 369723.Strop_1655 3.2e-14 85.5 Micromonosporales Bacteria 2I2JE@201174,4DMR8@85008,COG0723@1,COG0723@2 NA|NA|NA C Rieske [2Fe-2S] domain MAG.T1.179_01991 1048339.KB913029_gene4399 0.0 1507.3 Frankiales uvrA GO:0000018,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045910,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0071944,GO:0080090 ko:K03701 ko03420,map03420 ko00000,ko00001,ko03400 Bacteria 2GJUV@201174,4ERXD@85013,COG0178@1,COG0178@2 NA|NA|NA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate MAG.T1.179_01992 1449976.KALB_6759 4.1e-91 341.7 Pseudonocardiales alx ko:K05794 ko00000 Bacteria 2GIWU@201174,4DYPS@85010,COG0861@1,COG0861@2 NA|NA|NA P PFAM Integral membrane protein TerC MAG.T1.179_01993 710696.Intca_1671 0.0 1086.2 Intrasporangiaceae uvrB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 ko:K03702,ko:K08999 ko03420,map03420 ko00000,ko00001,ko03400 Bacteria 2GJ03@201174,4FF7R@85021,COG0556@1,COG0556@2 NA|NA|NA L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage MAG.T1.179_01994 1111729.ATYV01000023_gene1471 6.3e-50 204.1 Corynebacteriaceae coaE GO:0005575,GO:0005622,GO:0005623,GO:0009579,GO:0016020,GO:0034357,GO:0042651,GO:0044424,GO:0044436,GO:0044464 2.7.1.24 ko:K00859,ko:K02096,ko:K02286,ko:K02290,ko:K02630,ko:K05378,ko:K05379,ko:K05380 ko00196,ko00770,ko01100,map00196,map00770,map01100 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko00194,ko01000 Bacteria 22MZB@1653,2GN96@201174,COG0237@1,COG0237@2 NA|NA|NA F Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A MAG.T1.179_01995 479435.Kfla_3091 3.2e-32 146.4 Propionibacteriales ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GJV2@201174,4DQVU@85009,COG2244@1,COG2244@2 NA|NA|NA S polysaccharide biosynthetic process MAG.T1.179_01996 1283287.KB822576_gene3718 2.5e-41 175.3 Propionibacteriales rpsA GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 ko:K02945 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GJAK@201174,4DPIM@85009,COG0539@1,COG0539@2 NA|NA|NA J ribosomal protein MAG.T1.179_01999 590998.Celf_3037 4.1e-75 288.5 Actinobacteria Bacteria 2IG08@201174,COG1216@1,COG1216@2 NA|NA|NA M Glycosyltransferase, group 2 family protein MAG.T1.179_02000 1449069.JMLO01000017_gene3331 3.8e-84 319.3 Actinobacteria Bacteria 2C825@1,2IGR2@201174,32RK8@2 NA|NA|NA MAG.T1.179_02002 1068980.ARVW01000001_gene6598 8.8e-54 217.2 Actinobacteria Bacteria 2GNFE@201174,COG0558@1,COG0558@2 NA|NA|NA I Belongs to the CDP-alcohol phosphatidyltransferase class-I family MAG.T1.179_02003 590998.Celf_3031 9e-45 186.4 Actinobacteria tagD 2.7.7.39 ko:K00980 ko00564,map00564 R00856 RC00002 ko00000,ko00001,ko01000 Bacteria 2GKU1@201174,COG0615@1,COG0615@2 NA|NA|NA IM Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose MAG.T1.179_02004 979556.MTES_0953 1.3e-53 217.2 Bacteria wcoF Bacteria COG0438@1,COG0438@2 NA|NA|NA M transferase activity, transferring glycosyl groups MAG.T1.179_02005 1120936.KB907208_gene780 3.8e-74 285.8 Streptosporangiales rfbP Bacteria 2GK0M@201174,4EGMN@85012,COG2148@1,COG2148@2 NA|NA|NA M Bacterial sugar transferase MAG.T1.179_02006 1463901.JOIY01000024_gene6226 9.1e-207 726.5 Actinobacteria serA 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GJGA@201174,COG0111@1,COG0111@2 NA|NA|NA E Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family MAG.T1.179_02007 1032480.MLP_18030 2.5e-157 561.6 Propionibacteriales ilvC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0008677,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKXA@201174,4DNFA@85009,COG0059@1,COG0059@2 NA|NA|NA EH Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate MAG.T1.179_02008 222534.KB893794_gene2458 1.4e-66 259.2 Frankiales ilvN GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0030312,GO:0032991,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 iECO103_1326.ilvN,iJN678.ilvN Bacteria 2GJCH@201174,4ESEU@85013,COG0440@1,COG0440@2 NA|NA|NA E Acetolactate synthase, small subunit MAG.T1.179_02009 1048339.KB913029_gene3459 9.3e-269 932.6 Frankiales ilvB 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKU4@201174,4ES0H@85013,COG0028@1,COG0028@2 NA|NA|NA E TIGRFAM Acetolactate synthase, large subunit, biosynthetic MAG.T1.179_02010 1122236.KB905144_gene2309 4.8e-123 448.7 Nitrosomonadales Bacteria 1MU2C@1224,2KNM3@206350,2VIDG@28216,COG5001@1,COG5001@2 NA|NA|NA T Putative diguanylate phosphodiesterase MAG.T1.179_02011 1120950.KB892741_gene2670 5.4e-258 896.7 Propionibacteriales ilvD GO:0003674,GO:0003824,GO:0004160,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJIJ@201174,4DNV7@85009,COG0129@1,COG0129@2 NA|NA|NA EG Belongs to the IlvD Edd family MAG.T1.179_02012 1121946.AUAX01000019_gene7777 9.7e-63 246.9 Actinobacteria Bacteria 2ISWE@201174,COG3340@1,COG3340@2 NA|NA|NA E Peptidase family S51 MAG.T1.179_02013 351607.Acel_2052 1.3e-64 253.8 Actinobacteria 3.4.13.21,3.4.15.6 ko:K05995,ko:K13282 R09722 RC00064,RC00141 ko00000,ko01000,ko01002 Bacteria 2I98G@201174,COG0215@1,COG0215@2,COG4242@1,COG4242@2 NA|NA|NA J Belongs to the peptidase S51 family MAG.T1.179_02014 1463825.JNXC01000005_gene2483 2.9e-49 201.8 Pseudonocardiales bioY ko:K02014,ko:K03523 ko02010,map02010 M00581,M00582 ko00000,ko00001,ko00002,ko02000 1.B.14,2.A.88.1,2.A.88.2 Bacteria 2GJ53@201174,4E2ZE@85010,COG1268@1,COG1268@2 NA|NA|NA S BioY family MAG.T1.179_02015 1032480.MLP_29440 3e-207 728.0 Propionibacteriales gatB GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 Bacteria 2GJJH@201174,4DNB4@85009,COG0064@1,COG0064@2 NA|NA|NA J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) MAG.T1.179_02016 235985.BBPN01000056_gene7833 2.4e-217 761.5 Streptacidiphilus gatA 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 Bacteria 2GJK5@201174,2NHY5@228398,COG0154@1,COG0154@2 NA|NA|NA J Amidase MAG.T1.179_02017 1122182.KB903834_gene5703 3.4e-25 120.9 Micromonosporales gatC GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 Bacteria 2IQJN@201174,4DEPX@85008,COG0721@1,COG0721@2 NA|NA|NA J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) MAG.T1.179_02018 1464048.JNZS01000028_gene1698 2.3e-164 585.5 Micromonosporales ligA GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016874,GO:0016886,GO:0030312,GO:0033554,GO:0034641,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 Bacteria 2GJUY@201174,4D8P7@85008,COG0272@1,COG0272@2 NA|NA|NA L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA MAG.T1.179_02019 1504319.GM45_4210 1.3e-66 260.0 unclassified Actinobacteria (class) ligA GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016874,GO:0016886,GO:0030312,GO:0033554,GO:0034641,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 Bacteria 2GJUY@201174,3UW7F@52018,COG0272@1,COG0272@2 NA|NA|NA L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA MAG.T1.179_02020 981369.JQMJ01000004_gene5729 2.1e-60 239.6 Streptacidiphilus 2.1.1.14 ko:K00549 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R04405,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 Bacteria 2GMPS@201174,2NF4D@228398,COG0620@1,COG0620@2 NA|NA|NA E Cobalamin-independent synthase, Catalytic domain MAG.T1.179_02021 1122919.KB905604_gene4558 3.7e-81 308.5 Paenibacillaceae ygjR GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0055114,GO:0102497 ko:K22230 ko00562,ko01120,map00562,map01120 R09954 RC00182 ko00000,ko00001,ko01000 Bacteria 1TQSS@1239,26SCY@186822,4HCIG@91061,COG0673@1,COG0673@2 NA|NA|NA S Oxidoreductase MAG.T1.179_02022 1172188.KB911821_gene1287 1.1e-15 89.4 Intrasporangiaceae Bacteria 2E45J@1,2GR89@201174,32Z1K@2,4FHGH@85021 NA|NA|NA S Branched-chain amino acid transport protein (AzlD) MAG.T1.179_02023 1123251.ATWM01000001_gene699 1.3e-43 183.3 Intrasporangiaceae Bacteria 2GN6R@201174,4FFT4@85021,COG1296@1,COG1296@2 NA|NA|NA E branched-chain amino acid MAG.T1.179_02024 452652.KSE_51040 2.9e-132 478.4 Kitasatospora mnmA 2.8.1.13 ko:K00566 ko04122,map04122 R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 Bacteria 2GIUQ@201174,2M13X@2063,COG0482@1,COG0482@2 NA|NA|NA J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 MAG.T1.179_02025 1348663.KCH_51370 3.8e-120 438.3 Kitasatospora iscS GO:0003674,GO:0003824,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0016740,GO:0016782,GO:0016783,GO:0022607,GO:0031071,GO:0031163,GO:0040007,GO:0044085,GO:0044237,GO:0051186,GO:0071840 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 Bacteria 2GKUT@201174,2M12X@2063,COG1104@1,COG1104@2 NA|NA|NA E Beta-eliminating lyase MAG.T1.179_02026 561175.KB894094_gene1960 3.5e-105 388.3 Streptosporangiales etfA GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 ko:K03522 ko00000,ko04147 Bacteria 2GJWH@201174,4EGI3@85012,COG2025@1,COG2025@2 NA|NA|NA C Electron transfer flavoprotein domain MAG.T1.179_02027 469371.Tbis_2846 1.7e-84 319.3 Pseudonocardiales etfB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016020,GO:0016491,GO:0016627,GO:0016628,GO:0022900,GO:0030312,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071944,GO:0071949,GO:0097159,GO:1901265,GO:1901363 1.3.1.108 ko:K03521,ko:K22431 ko00000,ko01000 iAF987.Gmet_2067,iHN637.CLJU_RS19405 Bacteria 2GKV6@201174,4E0JQ@85010,COG2086@1,COG2086@2 NA|NA|NA C Electron transfer flavoprotein MAG.T1.179_02028 1089545.KB913037_gene6123 7.5e-95 354.4 Pseudonocardiales GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0040007,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.4.1.11,2.4.1.18 ko:K16149,ko:K16150 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R00292,R02110 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 GH57,GT4 Bacteria 2I2EE@201174,4DZ70@85010,COG0297@1,COG0297@2 NA|NA|NA G Glycosyl transferases group 1 MAG.T1.179_02029 105420.BBPO01000043_gene3657 8.1e-77 293.9 Streptacidiphilus ko:K07052 ko00000 Bacteria 2GK11@201174,2NHZA@228398,COG1266@1,COG1266@2 NA|NA|NA S CAAX protease self-immunity MAG.T1.179_02031 1110697.NCAST_19_00740 7.1e-09 65.5 Nocardiaceae 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 Bacteria 2GIRF@201174,4FVQ3@85025,COG2217@1,COG2217@2 NA|NA|NA P Heavy-metal-associated domain MAG.T1.179_02032 1366050.N234_19840 1.8e-38 165.6 Burkholderiaceae ypeA ko:K03826 ko00000,ko01000 Bacteria 1K7QV@119060,1RA6D@1224,2VSN2@28216,COG0454@1,COG0456@2 NA|NA|NA K PFAM GCN5-related N-acetyltransferase MAG.T1.179_02033 591167.Sfla_5812 9.3e-37 160.2 Actinobacteria 3.6.1.13 ko:K01515 ko00230,map00230 R01054 RC00002 ko00000,ko00001,ko01000 Bacteria 2GRXY@201174,COG0494@1,COG0494@2 NA|NA|NA L NUDIX domain MAG.T1.179_02035 1095767.CAHD01000239_gene1882 5.6e-62 244.6 Actinobacteria ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 28JAE@1,2IFSW@201174,2Z957@2 NA|NA|NA MAG.T1.179_02036 593907.Celgi_2332 7.4e-106 390.6 Cellulomonadaceae ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GJDP@201174,4F0GT@85016,COG1131@1,COG1131@2 NA|NA|NA V PFAM ABC transporter related MAG.T1.179_02037 397278.JOJN01000003_gene2085 5e-178 630.6 Propionibacteriales desA3 1.14.19.3 ko:K00508 ko00591,ko01100,map00591,map01100 R07063 RC00917 ko00000,ko00001,ko01000,ko01004 Bacteria 2GJKF@201174,4DNPH@85009,COG3239@1,COG3239@2 NA|NA|NA I Fatty acid desaturase MAG.T1.179_02038 1386089.N865_18720 4.6e-136 491.1 Intrasporangiaceae Bacteria 2GJSW@201174,4FEMH@85021,COG1018@1,COG1018@2 NA|NA|NA C Stearoyl-CoA 9-desaturase MAG.T1.179_02039 1380347.JNII01000011_gene840 7.1e-106 391.0 Frankiales Bacteria 2GR38@201174,4ESI5@85013,COG2508@1,COG2508@2 NA|NA|NA QT transcriptional regulator, PucR family MAG.T1.179_02040 479431.Namu_5174 4.9e-166 591.7 Frankiales ko:K06994 ko00000 Bacteria 2GJ5A@201174,4ESAG@85013,COG2409@1,COG2409@2 NA|NA|NA S MMPL family MAG.T1.179_02041 1122933.JNIY01000003_gene727 1.6e-63 250.4 Cellulomonadaceae ko:K03281 ko00000 2.A.49 Bacteria 2GJHP@201174,4F2KU@85016,COG0038@1,COG0038@2 NA|NA|NA P Voltage gated chloride channel MAG.T1.179_02042 1499967.BAYZ01000019_gene6314 4.2e-24 117.9 unclassified Bacteria sixA 3.6.1.55 ko:K03574,ko:K08296 ko00000,ko01000,ko03400 Bacteria 2NRKX@2323,COG2062@1,COG2062@2 NA|NA|NA T Histidine phosphatase superfamily (branch 1) MAG.T1.179_02043 1255043.TVNIR_2461 7.1e-14 83.6 Chromatiales ko:K11312 ko00000 Bacteria 1QUHG@1224,1T1Z6@1236,1WZ1B@135613,COG0662@1,COG0662@2 NA|NA|NA G PFAM Cupin 2, conserved barrel MAG.T1.179_02044 1120949.KB903335_gene9688 2.5e-32 145.2 Actinobacteria Bacteria 2H6QZ@201174,COG4803@1,COG4803@2 NA|NA|NA S membrane protein of uknown function UCP014873 MAG.T1.179_02046 1032480.MLP_42530 2.6e-34 152.5 Actinobacteria Bacteria 2I6ZG@201174,COG0639@1,COG0639@2 NA|NA|NA T Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP MAG.T1.179_02047 1211815.CBYP010000005_gene232 5.7e-16 92.0 Actinobacteria Bacteria 2GVAC@201174,COG1277@1,COG1277@2 NA|NA|NA S ABC-type transport system involved in multi-copper enzyme maturation permease component MAG.T1.179_02048 1380393.JHVP01000007_gene4343 2e-86 325.9 Actinobacteria ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GN8P@201174,COG1131@1,COG1131@2 NA|NA|NA V ABC transporter MAG.T1.179_02049 685727.REQ_07710 1e-29 137.1 Nocardiaceae Bacteria 2I2JW@201174,4G9F0@85025,COG0500@1,COG2226@2 NA|NA|NA Q Thiopurine S-methyltransferase (TPMT) MAG.T1.179_02050 469371.Tbis_3425 4e-47 194.1 Pseudonocardiales panD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0016485,GO:0016540,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0051604,GO:0071704,GO:1901564 4.1.1.11 ko:K01579 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R00489 RC00299 ko00000,ko00001,ko00002,ko01000 iECP_1309.ECP_0139,iYL1228.KPN_00139 Bacteria 2IHTC@201174,4E2JG@85010,COG0853@1,COG0853@2 NA|NA|NA H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine MAG.T1.179_02051 1137268.AZXF01000026_gene2413 1.7e-26 126.3 Streptosporangiales ko:K06950 ko00000 Bacteria 2IAVS@201174,4EJTM@85012,COG1418@1,COG1418@2 NA|NA|NA S PFAM metal-dependent phosphohydrolase, HD sub domain MAG.T1.179_02052 760011.Spico_1472 2.3e-112 412.1 Spirochaetes metAA GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0008899,GO:0009001,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016407,GO:0016412,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016750,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.46 ko:K00651 ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230 M00017 R01777 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS11970,iLJ478.TM0881 Bacteria 2J60Z@203691,COG1897@1,COG1897@2 NA|NA|NA E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine MAG.T1.179_02053 350054.Mflv_0939 5.7e-11 73.2 Mycobacteriaceae Bacteria 23B65@1762,2EK1R@1,2GWKM@201174,33DS7@2 NA|NA|NA S Phospholipase_D-nuclease N-terminal MAG.T1.179_02054 478741.JAFS01000001_gene1899 1.3e-54 219.9 unclassified Verrucomicrobia fabI GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0034641,GO:0042364,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.10,1.3.1.9 ko:K00208 ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212 M00083,M00572 R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671 RC00052,RC00076,RC00120 ko00000,ko00001,ko00002,ko01000,ko01004 iECUMN_1333.ECUMN_1592 Bacteria 37G8S@326457,46UJB@74201,COG0623@1,COG0623@2 NA|NA|NA I Enoyl-(Acyl carrier protein) reductase MAG.T1.179_02055 1304865.JAGF01000001_gene688 1.7e-156 558.9 Actinobacteria Bacteria 28IW2@1,2IA78@201174,2Z8UC@2 NA|NA|NA MAG.T1.179_02056 1304865.JAGF01000001_gene687 0.0 1289.2 Cellulomonadaceae hppA 3.6.1.1 ko:K15987 ko00190,map00190 ko00000,ko00001,ko01000 3.A.10.1 Bacteria 2GN8B@201174,4F0E3@85016,COG3808@1,COG3808@2 NA|NA|NA C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force MAG.T1.179_02057 471852.Tcur_3681 1.1e-99 369.8 Streptosporangiales atrC 3.6.3.21 ko:K02028 M00236 ko00000,ko00002,ko01000,ko02000 3.A.1.3 Bacteria 2GIZW@201174,4EHV2@85012,COG1126@1,COG1126@2 NA|NA|NA E ATPases associated with a variety of cellular activities MAG.T1.179_02058 263358.VAB18032_26240 3.4e-103 381.7 Micromonosporales ko:K02029,ko:K10009 ko02010,map02010 M00234,M00236 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.10,3.A.1.3.14 Bacteria 2GJJ9@201174,4DAHV@85008,COG0765@1,COG0765@2 NA|NA|NA E ABC-type amino acid transport system, permease component MAG.T1.179_02059 263358.VAB18032_26245 2.7e-86 325.5 Micromonosporales pknD ko:K02030 M00236 ko00000,ko00002,ko02000 3.A.1.3 Bacteria 2GJQW@201174,4DCDW@85008,COG0834@1,COG0834@2 NA|NA|NA ET ABC-type amino acid transport signal transduction systems, periplasmic component domain MAG.T1.179_02060 1463856.JOHY01000004_gene6505 1.3e-20 107.1 Actinobacteria 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 2GJ6V@201174,COG0204@1,COG0204@2 NA|NA|NA I Acyltransferase MAG.T1.179_02061 525904.Tter_2417 1.7e-10 72.0 Bacteria ko:K09932 ko00000 Bacteria COG3224@1,COG3224@2 NA|NA|NA MAG.T1.179_02062 134676.ACPL_4177 2.7e-59 236.5 Actinobacteria Bacteria 2ID0G@201174,COG2199@1,COG3706@2 NA|NA|NA T GGDEF domain MAG.T1.179_02064 93220.LV28_08510 2e-210 738.8 Burkholderiaceae recQ GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008270,GO:0009295,GO:0009378,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017116,GO:0017117,GO:0030894,GO:0032392,GO:0032508,GO:0032991,GO:0032993,GO:0033202,GO:0033554,GO:0034641,GO:0042623,GO:0043138,GO:0043140,GO:0043142,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1904949 3.6.4.12 ko:K03654 ko03018,map03018 ko00000,ko00001,ko01000,ko03400 Bacteria 1K353@119060,1MVGG@1224,2VH8W@28216,COG0514@1,COG0514@2 NA|NA|NA L ATP-dependent DNA helicase RecQ MAG.T1.179_02065 1146883.BLASA_3489 2.2e-134 486.1 Actinobacteria Bacteria 2H3MV@201174,COG0210@1,COG0210@2,COG1112@1,COG1112@2 NA|NA|NA L Type III restriction enzyme res subunit MAG.T1.179_02066 219305.MCAG_03346 3.2e-24 117.9 Micromonosporales Bacteria 2IMGG@201174,4DF47@85008,COG1846@1,COG1846@2 NA|NA|NA K MarR family MAG.T1.179_02067 1172181.KB911720_gene4092 8.6e-08 61.6 Actinobacteria nagB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 3.1.1.31,3.5.99.6 ko:K01057,ko:K02564,ko:K02804 ko00030,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko02060,map00030,map00520,map01100,map01110,map01120,map01130,map01200,map02060 M00004,M00006,M00008,M00267 R00765,R02035,R05199 RC00017,RC00163,RC00537,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7 Bacteria 2GK7F@201174,COG0363@1,COG0363@2 NA|NA|NA G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion MAG.T1.179_02068 1205680.CAKO01000002_gene2132 4.3e-20 104.4 Rhodospirillales Bacteria 1MZR5@1224,2JU1E@204441,2UCIB@28211,COG3339@1,COG3339@2 NA|NA|NA S Protein of unknown function (DUF1232) MAG.T1.179_02069 469371.Tbis_1836 3.3e-166 591.7 Pseudonocardiales dop GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 3.5.1.119,6.3.1.19 ko:K13571,ko:K20814 M00342 R11207 RC00090,RC00096 ko00000,ko00002,ko01000,ko03051 Bacteria 2GJGI@201174,4DZ25@85010,COG4122@1,COG4122@2 NA|NA|NA S proteasome accessory factor PafA2 MAG.T1.179_02070 446466.Cfla_2002 1e-09 68.9 Cellulomonadaceae pup GO:0003674,GO:0005488,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0031386,GO:0032446,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044877,GO:0051603,GO:0070490,GO:0070628,GO:0070647,GO:0071704,GO:1901564,GO:1901565,GO:1901575 ko:K13570 ko00000,ko04121 Bacteria 2E9C2@1,2I1D6@201174,333JS@2,4F1MQ@85016 NA|NA|NA S Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation MAG.T1.179_02071 479435.Kfla_3226 6.5e-95 354.0 Propionibacteriales prcB GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019774,GO:0019899,GO:0019941,GO:0030163,GO:0032991,GO:0035375,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 ko:K03433 ko03050,map03050 M00342,M00343 ko00000,ko00001,ko00002,ko01000,ko01002,ko03051 Bacteria 2GJ60@201174,4DPD6@85009,COG0638@1,COG0638@2 NA|NA|NA O Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation MAG.T1.179_02072 1184609.KILIM_006_00080 1.1e-79 303.1 Dermatophilaceae prcA GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019773,GO:0019941,GO:0030163,GO:0030312,GO:0032991,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 ko:K03432 ko03050,map03050 M00342,M00343 ko00000,ko00001,ko00002,ko01000,ko01002,ko03051 Bacteria 2GKZ1@201174,4F6S2@85018,COG0638@1,COG0638@2 NA|NA|NA O Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation MAG.T1.179_02073 1123320.KB889667_gene2950 1.1e-197 696.0 Actinobacteria pafA GO:0000166,GO:0000302,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0016020,GO:0016740,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019787,GO:0019941,GO:0030163,GO:0030312,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034599,GO:0034614,GO:0035639,GO:0035690,GO:0036094,GO:0036211,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044464,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070490,GO:0070647,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097159,GO:0097366,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170 6.3.1.19 ko:K13571 M00342 R11207 RC00090,RC00096 ko00000,ko00002,ko01000,ko03051 Bacteria 2GMC6@201174,COG0638@1,COG0638@2 NA|NA|NA O Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine MAG.T1.179_02074 1229780.BN381_350110 1.5e-27 129.8 unclassified Actinobacteria (class) Bacteria 2IHQC@201174,3UWVE@52018,COG0545@1,COG0545@2 NA|NA|NA O FKBP-type peptidyl-prolyl cis-trans isomerase MAG.T1.179_02075 1150599.MPHLEI_21374 1.9e-43 181.8 Mycobacteriaceae fkb 5.2.1.8 ko:K01802,ko:K03772 ko00000,ko01000,ko03110 Bacteria 239F5@1762,2IHQC@201174,COG0545@1,COG0545@2 NA|NA|NA O Peptidyl-prolyl cis-trans isomerase MAG.T1.179_02076 1236902.ANAS01000037_gene5402 6.8e-87 328.6 Streptosporangiales pafB GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 ko:K13572,ko:K13573 ko00000,ko03051 Bacteria 2GM46@201174,4EFRP@85012,COG2378@1,COG2378@2 NA|NA|NA K WYL domain MAG.T1.179_02077 266940.Krad_1881 1.4e-16 92.4 Actinobacteria Bacteria 2BZPH@1,2IQ4A@201174,33EX8@2 NA|NA|NA MAG.T1.179_02078 106370.Francci3_2305 6.1e-12 76.6 Frankiales tatA ko:K03116 ko03060,ko03070,map03060,map03070 M00336 ko00000,ko00001,ko00002,ko02044 2.A.64 Bacteria 2GQQX@201174,4ETM8@85013,COG1826@1,COG1826@2 NA|NA|NA U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system MAG.T1.179_02079 1504319.GM45_0890 2.8e-63 248.8 unclassified Actinobacteria (class) tatC GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 ko:K03118 ko03060,ko03070,map03060,map03070 M00336 ko00000,ko00001,ko00002,ko02044 2.A.64 Bacteria 2GJK8@201174,3UWSI@52018,COG0805@1,COG0805@2 NA|NA|NA U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides MAG.T1.179_02080 1121272.KB903257_gene5486 3.3e-65 255.4 Micromonosporales dagK GO:0003674,GO:0003824,GO:0004143,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.1.107 ko:K07029 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 R02240 RC00002,RC00017 ko00000,ko00001,ko01000 Bacteria 2GK3P@201174,4D9SI@85008,COG1597@1,COG1597@2 NA|NA|NA I Diacylglycerol kinase MAG.T1.179_02081 1123322.KB904647_gene1742 6.3e-301 1040.0 Actinobacteria helY GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575 ko:K03727 ko00000,ko01000 Bacteria 2GJEX@201174,COG4581@1,COG4581@2 NA|NA|NA L DEAD DEAH box helicase MAG.T1.179_02083 266940.Krad_1887 4.1e-87 328.2 Actinobacteria polA GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 Bacteria 2GKTZ@201174,COG0258@1,COG0258@2 NA|NA|NA L 5'-3' exonuclease MAG.T1.179_02084 436229.JOEH01000002_gene3343 2.4e-132 478.8 Streptacidiphilus acdA ko:K18244 ko00000,ko01000 Bacteria 2GIX8@201174,2NHRD@228398,COG1960@1,COG1960@2 NA|NA|NA I Acyl-CoA dehydrogenase, C-terminal domain MAG.T1.179_02085 1298863.AUEP01000008_gene1335 2.6e-197 694.9 Propionibacteriales kamA1 5.4.3.2 ko:K01843 ko00310,map00310 R00461 RC00303 ko00000,ko00001,ko01000 Bacteria 2GM2P@201174,4DP5B@85009,COG1509@1,COG1509@2 NA|NA|NA E lysine 2,3-aminomutase MAG.T1.179_02086 219305.MCAG_00044 4.2e-123 448.0 Micromonosporales kdd 1.4.1.11 ko:K18012 ko00310,map00310 R03349 RC00888 ko00000,ko00001,ko01000 Bacteria 2GK3U@201174,4DA07@85008,COG1063@1,COG1063@2 NA|NA|NA E Dehydrogenase MAG.T1.179_02087 1463856.JOHY01000016_gene5622 1e-152 547.0 Actinobacteria ytcJ Bacteria 2GJVW@201174,COG1574@1,COG1574@2 NA|NA|NA E amidohydrolase MAG.T1.179_02088 1120950.KB892708_gene4481 1.2e-222 779.2 Propionibacteriales deoC GO:0003674,GO:0003824,GO:0004139,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 4.1.2.4,5.4.3.3 ko:K01619,ko:K01844 ko00030,ko00310,map00030,map00310 R01066,R02852,R03275 RC00436,RC00437,RC00719 ko00000,ko00001,ko01000 Bacteria 2GUM7@201174,4DNH2@85009,COG0274@1,COG0274@2 NA|NA|NA F D-Lysine 5,6-aminomutase TIM-barrel domain of alpha subunit MAG.T1.179_02089 1122609.AUGT01000003_gene2193 1.3e-94 352.8 Propionibacteriales kamE 5.4.3.3,5.4.3.5 ko:K17898,ko:K18011 ko00310,ko00472,map00310,map00472 R02461,R02852,R03275 RC00719 ko00000,ko00001,ko01000 Bacteria 2HF50@201174,4DNBN@85009,COG2185@1,COG2185@2 NA|NA|NA I Dimerisation domain of d-ornithine 4,5-aminomutase MAG.T1.179_02090 1120934.KB894404_gene715 2e-44 185.3 Pseudonocardiales 4.3.1.14 ko:K18014 ko00310,map00310 R03030 RC00833 ko00000,ko00001,ko01000 Bacteria 2IKM2@201174,4E3PP@85010,COG1607@1,COG1607@2 NA|NA|NA I Thioesterase superfamily MAG.T1.179_02091 561175.KB894096_gene668 8.6e-112 411.0 Streptosporangiales lnt ko:K03820 ko00000,ko01000 GT2 Bacteria 2GJ9F@201174,4EHTJ@85012,COG0815@1,COG0815@2 NA|NA|NA M Transfers the fatty acyl group on membrane lipoproteins MAG.T1.179_02092 452652.KSE_45450 2.4e-97 362.1 Kitasatospora dpm1 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 R01009 RC00005 ko00000,ko00001,ko01000,ko01003 GT2 Bacteria 2I2FA@201174,2M0M1@2063,COG1216@1,COG1216@2 NA|NA|NA S Glycosyltransferase like family 2 MAG.T1.179_02094 479433.Caci_5317 7.8e-34 149.8 Actinobacteria rbpA GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 Bacteria 2CNY9@1,2I80U@201174,31DSU@2 NA|NA|NA K RNA polymerase-binding protein MAG.T1.179_02095 1288494.EBAPG3_12090 2.6e-15 89.7 Nitrosomonadales Bacteria 1PWB7@1224,2BTJW@1,2WBVY@28216,32NSK@2,373WE@32003 NA|NA|NA MAG.T1.179_02096 1236902.ANAS01000037_gene5376 5.2e-59 234.6 Streptosporangiales glpQ2 3.1.4.46 ko:K01126 ko00564,map00564 R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 Bacteria 2GJ5W@201174,4EIE7@85012,COG0584@1,COG0584@2 NA|NA|NA C Glycerophosphoryl diester phosphodiesterase family MAG.T1.179_02097 543632.JOJL01000020_gene553 2.5e-55 223.4 Micromonosporales ko:K14645 ko02024,map02024 ko00000,ko00001,ko01000,ko01002,ko03110 Bacteria 2GIRE@201174,4DAEM@85008,COG1404@1,COG1404@2 NA|NA|NA O Belongs to the peptidase S8 family MAG.T1.179_02098 1193181.BN10_560016 2.1e-184 652.1 Intrasporangiaceae Bacteria 2HZZ8@201174,4FHJM@85021,COG4974@1,COG4974@2 NA|NA|NA L Belongs to the 'phage' integrase family MAG.T1.179_02099 1121933.AUHH01000010_gene2518 1.8e-46 191.8 Actinobacteria ko:K07727 ko00000,ko03000 Bacteria 2ISZ0@201174,COG3655@1,COG3655@2 NA|NA|NA K Cro/C1-type HTH DNA-binding domain MAG.T1.179_02100 1121933.AUHH01000010_gene2519 2.7e-173 614.8 Actinobacteria Bacteria 2IC5F@201174,COG4974@1,COG4974@2 NA|NA|NA L Belongs to the 'phage' integrase family MAG.T1.179_02101 266940.Krad_3763 2.2e-99 368.6 Actinobacteria rph GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006401,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019439,GO:0022613,GO:0031123,GO:0031125,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0042254,GO:0043170,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:1901361,GO:1901575 2.7.7.56,3.6.1.66 ko:K00989,ko:K02428 ko00230,map00230 R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000,ko03016 Bacteria 2GJFI@201174,COG0689@1,COG0689@2 NA|NA|NA J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates MAG.T1.179_02102 1394178.AWOO02000078_gene2041 1e-70 273.5 Streptosporangiales yhfI GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267 Bacteria 2GMEX@201174,4EIG9@85012,COG1234@1,COG1234@2 NA|NA|NA S Beta-lactamase superfamily domain MAG.T1.179_02103 1146883.BLASA_1169 9.8e-99 366.7 Frankiales murI GO:0000270,GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008657,GO:0008881,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0010911,GO:0016020,GO:0016853,GO:0016854,GO:0016855,GO:0030203,GO:0030234,GO:0032780,GO:0034645,GO:0036361,GO:0042030,GO:0042546,GO:0042802,GO:0043086,GO:0043170,GO:0043462,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0047661,GO:0050790,GO:0051336,GO:0051346,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0072586,GO:0098772,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:2000371,GO:2000372 3.6.1.66,5.1.1.3 ko:K01776,ko:K02428 ko00230,ko00471,ko01100,map00230,map00471,map01100 R00260,R00426,R00720,R01855,R02100,R02720,R03531 RC00002,RC00302 ko00000,ko00001,ko01000,ko01011 iYO844.BSU28390 Bacteria 2GN4I@201174,4ERE1@85013,COG0796@1,COG0796@2 NA|NA|NA M Provides the (R)-glutamate required for cell wall biosynthesis MAG.T1.179_02104 1134445.AJJM01000020_gene2028 2.6e-30 137.9 Actinobacteria clpS GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0050896,GO:0051087 ko:K06891 ko00000 Bacteria 2IQ3Z@201174,COG2127@1,COG2127@2 NA|NA|NA S Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation MAG.T1.179_02105 471852.Tcur_3874 4e-29 134.8 Streptosporangiales Bacteria 2E4AX@1,2GW4T@201174,32Z6K@2,4EJ1I@85012 NA|NA|NA S Domain of unknown function (DUF2017) MAG.T1.179_02106 1313172.YM304_16100 2.9e-52 213.4 Actinobacteria Bacteria 2HZ7I@201174,COG3858@1,COG3858@2 NA|NA|NA S Glycosyl hydrolases family 18 MAG.T1.179_02107 1003195.SCAT_1840 2.3e-61 242.7 Actinobacteria prmC 2.1.1.297 ko:K02493 R10806 RC00003,RC03279 ko00000,ko01000,ko03012 Bacteria 2GNC1@201174,COG2890@1,COG2890@2 NA|NA|NA J Belongs to the protein N5-glutamine methyltransferase family MAG.T1.179_02108 223184.AS25_09540 2.1e-26 124.8 Micrococcaceae Bacteria 1W9TC@1268,2CAFG@1,2IQ98@201174,32RRB@2 NA|NA|NA S Protein of unknown function (DUF3039) MAG.T1.179_02109 1306174.JODP01000018_gene4493 2.2e-23 115.2 Actinobacteria wblB ko:K18955 ko00000,ko03000 Bacteria 2CC1Y@1,2IQS5@201174,32S23@2 NA|NA|NA K Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA MAG.T1.179_02110 1380356.JNIK01000015_gene2347 4.2e-115 421.4 Frankiales argF GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0033554,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 iAF1260.b0273,iECDH10B_1368.ECDH10B_0261,iECS88_1305.ECS88_4841,iHN637.CLJU_RS12430,iJO1366.b0273,iJR904.b0273,iY75_1357.Y75_RS01410 Bacteria 2GJ6H@201174,4ERRI@85013,COG0078@1,COG0078@2 NA|NA|NA E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline MAG.T1.179_02111 935839.JAGJ01000001_gene964 3.7e-260 904.0 Promicromonosporaceae pckG GO:0000003,GO:0001655,GO:0001822,GO:0001889,GO:0003006,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004457,GO:0004611,GO:0004613,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006066,GO:0006071,GO:0006082,GO:0006089,GO:0006090,GO:0006091,GO:0006094,GO:0006109,GO:0006111,GO:0006113,GO:0006139,GO:0006163,GO:0006464,GO:0006629,GO:0006631,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007028,GO:0007154,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007296,GO:0007610,GO:0008150,GO:0008152,GO:0008906,GO:0009056,GO:0009058,GO:0009062,GO:0009117,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009166,GO:0009167,GO:0009179,GO:0009185,GO:0009199,GO:0009205,GO:0009259,GO:0009267,GO:0009410,GO:0009605,GO:0009607,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009792,GO:0009887,GO:0009888,GO:0009889,GO:0009966,GO:0009967,GO:0009987,GO:0009991,GO:0010033,GO:0010106,GO:0010243,GO:0010646,GO:0010647,GO:0010675,GO:0010906,GO:0014070,GO:0014074,GO:0015036,GO:0015980,GO:0016020,GO:0016042,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016054,GO:0016301,GO:0016310,GO:0016491,GO:0016614,GO:0016651,GO:0016667,GO:0016668,GO:0016740,GO:0016772,GO:0016773,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017001,GO:0017144,GO:0018130,GO:0018991,GO:0019098,GO:0019222,GO:0019249,GO:0019318,GO:0019319,GO:0019320,GO:0019362,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019516,GO:0019538,GO:0019541,GO:0019543,GO:0019563,GO:0019626,GO:0019637,GO:0019659,GO:0019660,GO:0019661,GO:0019666,GO:0019674,GO:0019693,GO:0019725,GO:0019751,GO:0019752,GO:0019953,GO:0022412,GO:0022414,GO:0023051,GO:0023056,GO:0030003,GO:0030145,GO:0030154,GO:0030312,GO:0030703,GO:0030855,GO:0031323,GO:0031667,GO:0031668,GO:0031669,GO:0031960,GO:0031974,GO:0032501,GO:0032502,GO:0032504,GO:0032787,GO:0032868,GO:0032869,GO:0032870,GO:0033554,GO:0033993,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035690,GO:0036211,GO:0042221,GO:0042493,GO:0042592,GO:0042594,GO:0042737,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043255,GO:0043412,GO:0043434,GO:0043436,GO:0043687,GO:0043900,GO:0043903,GO:0043949,GO:0043950,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044267,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045471,GO:0046031,GO:0046034,GO:0046164,GO:0046174,GO:0046364,GO:0046365,GO:0046394,GO:0046395,GO:0046434,GO:0046459,GO:0046483,GO:0046496,GO:0046677,GO:0046683,GO:0046700,GO:0046872,GO:0046914,GO:0046916,GO:0047134,GO:0048468,GO:0048477,GO:0048513,GO:0048518,GO:0048522,GO:0048545,GO:0048562,GO:0048568,GO:0048583,GO:0048584,GO:0048598,GO:0048609,GO:0048646,GO:0048731,GO:0048732,GO:0048856,GO:0048869,GO:0048878,GO:0050789,GO:0050792,GO:0050794,GO:0050801,GO:0050896,GO:0051186,GO:0051384,GO:0051591,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055086,GO:0055114,GO:0060429,GO:0061005,GO:0061008,GO:0062012,GO:0065007,GO:0065008,GO:0070013,GO:0070365,GO:0070887,GO:0071236,GO:0071310,GO:0071361,GO:0071375,GO:0071383,GO:0071384,GO:0071385,GO:0071396,GO:0071407,GO:0071417,GO:0071466,GO:0071495,GO:0071496,GO:0071548,GO:0071549,GO:0071704,GO:0071840,GO:0071944,GO:0072001,GO:0072071,GO:0072329,GO:0072330,GO:0072521,GO:0072524,GO:0075136,GO:0080090,GO:0097159,GO:0097237,GO:0097305,GO:0097306,GO:0097327,GO:0098771,GO:1901135,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901575,GO:1901576,GO:1901615,GO:1901616,GO:1901617,GO:1901652,GO:1901653,GO:1901654,GO:1901655,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902531,GO:1902533 4.1.1.32,4.1.1.49 ko:K01596,ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964 M00003,M00170 R00341,R00431,R00726 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2638 Bacteria 2GJH3@201174,4F3XG@85017,COG1274@1,COG1274@2 NA|NA|NA H Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle MAG.T1.179_02112 1035308.AQYY01000001_gene2967 4.1e-25 120.6 Firmicutes Bacteria 1VCZF@1239,COG2329@1,COG2329@2 NA|NA|NA S Antibiotic biosynthesis monooxygenase MAG.T1.179_02114 644283.Micau_3475 5.2e-25 121.3 Micromonosporales ppaX 3.1.3.18,3.6.1.1 ko:K01091,ko:K06019,ko:K16017 ko00190,ko00630,ko01051,ko01100,ko01110,ko01130,map00190,map00630,map01051,map01100,map01110,map01130 R01334,R06587 RC00017,RC00078 ko00000,ko00001,ko01000 Bacteria 2I9FC@201174,4DFT5@85008,COG0546@1,COG0546@2 NA|NA|NA S HAD-superfamily hydrolase, subfamily IA, variant 3 MAG.T1.179_02115 1304865.JAGF01000001_gene1621 1.8e-309 1068.1 Cellulomonadaceae pfkA 2.7.1.11,2.7.1.90 ko:K00850,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 Bacteria 2GK6W@201174,4F0UZ@85016,COG0205@1,COG0205@2 NA|NA|NA H Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis MAG.T1.179_02116 1380354.JIAN01000005_gene1271 8.4e-175 620.9 Cellulomonadaceae 3.6.1.27 ko:K19302 ko00550,map00550 R05627 RC00002 ko00000,ko00001,ko01000,ko01011 Bacteria 2GMAV@201174,4F0KN@85016,COG0392@1,COG0392@2 NA|NA|NA S Lysylphosphatidylglycerol synthase TM region MAG.T1.179_02117 479431.Namu_0491 1.3e-30 139.0 Frankiales lsrG 5.3.1.32 ko:K11530 ko02024,map02024 ko00000,ko00001,ko01000 Bacteria 2GSE1@201174,4EX0G@85013,COG1359@1,COG1359@2 NA|NA|NA C Antibiotic biosynthesis monooxygenase MAG.T1.179_02118 479431.Namu_0492 3.7e-101 375.2 Actinobacteria eutG 1.1.1.1,4.3.3.7 ko:K00001,ko:K01714 ko00010,ko00071,ko00261,ko00300,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,ko01230,map00010,map00071,map00261,map00300,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220,map01230 M00016,M00525,M00526,M00527 R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310,R10147 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273,RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 Bacteria 2IDI8@201174,COG1454@1,COG1454@2 NA|NA|NA C Iron-containing alcohol dehydrogenase MAG.T1.179_02119 1173264.KI913949_gene3844 8.9e-64 250.8 Oscillatoriales panE 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2643 Bacteria 1G2H9@1117,1H7Y1@1150,COG1893@1,COG1893@2 NA|NA|NA H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid MAG.T1.179_02120 28444.JODQ01000007_gene5583 1.1e-36 160.2 Streptosporangiales chpE ko:K06600,ko:K06895 ko00000,ko02000,ko02035 2.A.75.1,2.A.76 Bacteria 2INXA@201174,4EPSU@85012,COG1280@1,COG1280@2 NA|NA|NA E LysE type translocator MAG.T1.179_02121 477641.MODMU_2141 5.8e-48 198.0 Frankiales yybG Bacteria 2GM3W@201174,4EUFF@85013,COG1357@1,COG1357@2 NA|NA|NA S Pentapeptide repeats (8 copies) MAG.T1.179_02122 644283.Micau_2859 1e-188 666.4 Micromonosporales ko:K01436 ko00000,ko01000,ko01002 Bacteria 2I2WA@201174,4DBB4@85008,COG1473@1,COG1473@2 NA|NA|NA S amidohydrolase MAG.T1.179_02123 326424.FRAAL4415 9.9e-56 223.8 Actinobacteria Bacteria 2GIV0@201174,COG0515@1,COG0515@2 NA|NA|NA KLT serine threonine protein kinase MAG.T1.179_02125 1121017.AUFG01000022_gene2176 2.2e-91 342.4 Intrasporangiaceae fieF Bacteria 2GJ8Q@201174,4FE8E@85021,COG0053@1,COG0053@2 NA|NA|NA P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family MAG.T1.179_02126 1123322.KB904635_gene2587 1e-110 406.8 Actinobacteria drrA3 ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GIY8@201174,COG1131@1,COG1131@2 NA|NA|NA V ABC transporter MAG.T1.179_02127 1463845.JOIG01000003_gene4753 3.3e-80 305.1 Actinobacteria ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GKJF@201174,COG0842@1,COG0842@2 NA|NA|NA V transport, permease protein MAG.T1.179_02131 512565.AMIS_48700 5.3e-114 417.9 Micromonosporales macB ko:K02004,ko:K05685 ko02010,map02010 M00258,M00709 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.122.1,3.A.1.122.12 Bacteria 2GIRW@201174,4D8TU@85008,COG0577@1,COG0577@2 NA|NA|NA V MacB-like periplasmic core domain MAG.T1.179_02132 1123320.KB889562_gene6766 9e-82 310.1 Actinobacteria ko:K02003 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GK3I@201174,COG1136@1,COG1136@2 NA|NA|NA V ABC transporter MAG.T1.179_02133 479432.Sros_8876 3.8e-29 136.3 Streptosporangiales hlyD3 ko:K02005,ko:K13888 M00709 ko00000,ko00002,ko02000 8.A.1 Bacteria 2H154@201174,4EGKC@85012,COG0845@1,COG0845@2 NA|NA|NA M HlyD family secretion protein MAG.T1.179_02134 512565.AMIS_33730 5.3e-09 67.0 Micromonosporales ko:K00375 ko00000,ko03000 Bacteria 2GITW@201174,4D9DH@85008,COG1167@1,COG1167@2 NA|NA|NA K Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs MAG.T1.179_02135 1280688.AUJB01000008_gene544 4.5e-48 198.4 Pseudobutyrivibrio ko:K02538 ko00000,ko03000 Bacteria 1TT5A@1239,24931@186801,3NGRF@46205,COG3711@1,COG3711@2 NA|NA|NA K CAT RNA binding domain MAG.T1.179_02136 526226.Gbro_2724 1.7e-82 312.8 Gordoniaceae ybhF GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015562,GO:0015893,GO:0016020,GO:0022857,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944 ko:K01990,ko:K01992,ko:K13926 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2ICIF@201174,4GGY6@85026,COG1131@1,COG1131@2 NA|NA|NA V AAA domain, putative AbiEii toxin, Type IV TA system MAG.T1.179_02137 1454010.JEOE01000004_gene138 2.5e-83 315.5 Cellulomonadaceae ybhF GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015562,GO:0015893,GO:0016020,GO:0022857,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944 ko:K01990,ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2IH64@201174,4F2FJ@85016,COG1131@1,COG1131@2 NA|NA|NA V ATPases associated with a variety of cellular activities MAG.T1.179_02138 644548.SCNU_19462 8.7e-129 466.8 Gordoniaceae ybhS ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GJ7Y@201174,4GCQ2@85026,COG0842@1,COG0842@2 NA|NA|NA U ABC-2 family transporter protein MAG.T1.179_02139 1273125.Rrhod_1412 6.8e-53 214.9 Nocardiaceae menE 6.2.1.26 ko:K01911 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R04030 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 Bacteria 2GN9C@201174,4FUUX@85025,COG0318@1,COG0318@2 NA|NA|NA IQ AMP-binding enzyme C-terminal domain MAG.T1.179_02140 1184609.KILIM_039_00360 6.1e-83 314.3 Dermatophilaceae menA GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006775,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009233,GO:0009234,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0032194,GO:0042180,GO:0042181,GO:0042362,GO:0042371,GO:0042373,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046428,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663 2.5.1.74 ko:K02548 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R05617,R06858,R10757 RC02935,RC02936,RC03264 ko00000,ko00001,ko00002,ko01000,ko01006 iECH74115_1262.ECH74115_5387,iG2583_1286.G2583_4737 Bacteria 2GJBS@201174,4F6JM@85018,COG1575@1,COG1575@2 NA|NA|NA H Belongs to the MenA family. Type 1 subfamily MAG.T1.179_02141 158189.SpiBuddy_1062 2.8e-50 204.9 Spirochaetes btuE 1.11.1.9 ko:K00432 ko00480,ko00590,ko04918,map00480,map00590,map04918 R00274,R07034,R07035 RC00011,RC00982 ko00000,ko00001,ko01000 Bacteria 2J843@203691,COG0386@1,COG0386@2 NA|NA|NA C Belongs to the glutathione peroxidase family MAG.T1.179_02142 1120950.KB892801_gene1792 6.1e-12 77.4 Propionibacteriales Bacteria 2EGDD@1,2HKYH@201174,33A58@2,4DSSA@85009 NA|NA|NA S Phospholipase_D-nuclease N-terminal MAG.T1.179_02144 1048339.KB913029_gene2342 5.7e-80 304.7 Frankiales ccsA GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008152,GO:0015886,GO:0016020,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0055114,GO:0071702,GO:0071705,GO:0071944,GO:1901678 Bacteria 2GJR1@201174,4ESE9@85013,COG0755@1,COG0755@2 NA|NA|NA O Cytochrome c-type biogenesis protein MAG.T1.179_02145 1120950.KB892801_gene1786 7.2e-127 461.1 Propionibacteriales resB ko:K07399 ko00000 Bacteria 2GMGH@201174,4DN12@85009,COG1333@1,COG1333@2 NA|NA|NA O ResB-like family MAG.T1.179_02146 1236902.ANAS01000019_gene4144 2.5e-73 282.3 Streptosporangiales ccdA ko:K06196 ko00000,ko02000 5.A.1.2 Bacteria 2GJW3@201174,4EHWN@85012,COG0785@1,COG0785@2 NA|NA|NA O Cytochrome C biogenesis protein transmembrane region MAG.T1.179_02147 269800.Tfu_2704 1.1e-43 183.3 Streptosporangiales resA ko:K02199 ko00000,ko03110 Bacteria 2GP7J@201174,4EJ9T@85012,COG0526@1,COG0526@2 NA|NA|NA CO Thioredoxin-like MAG.T1.179_02148 105420.BBPO01000037_gene311 2.5e-75 288.5 Streptacidiphilus GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 3.1.3.3,3.1.3.73 ko:K02226,ko:K22305 ko00260,ko00680,ko00860,ko01100,ko01120,ko01130,map00260,map00680,map00860,map01100,map01120,map01130 M00122 R00582,R04594,R11173 RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 2GMXF@201174,2NFB7@228398,COG0406@1,COG0406@2 NA|NA|NA G Phosphoglycerate mutase family MAG.T1.179_02149 656024.FsymDg_4039 1.5e-102 379.4 Frankiales hemL GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016853,GO:0016866,GO:0016869,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042286,GO:0042440,GO:0042802,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 iSB619.SA_RS08395,iUMNK88_1353.UMNK88_158 Bacteria 2GJSH@201174,4ERKP@85013,COG0001@1,COG0001@2 NA|NA|NA H PFAM Aminotransferase class-III MAG.T1.179_02151 446466.Cfla_3439 1.9e-125 455.7 Cellulomonadaceae hemB GO:0000287,GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 iECABU_c1320.ECABU_c04500,iEcSMS35_1347.EcSMS35_0398,iJN746.PP_2913,ic_1306.c0477 Bacteria 2GJJ0@201174,4F0TK@85016,COG0113@1,COG0113@2 NA|NA|NA H Belongs to the ALAD family MAG.T1.179_02152 471852.Tcur_4438 8.1e-163 580.5 Streptosporangiales hemD GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4 ko:K02302,ko:K02303,ko:K13542 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03165,R03194,R03947 RC00003,RC00871,RC01012,RC01034,RC01861 ko00000,ko00001,ko00002,ko01000 Bacteria 2GMJZ@201174,4EFW8@85012,COG0007@1,COG0007@2,COG1587@1,COG1587@2 NA|NA|NA H Uroporphyrinogen-III synthase HemD MAG.T1.179_02153 996637.SGM_1352 1.4e-74 286.6 Actinobacteria hemC GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 Bacteria 2GMWI@201174,COG0181@1,COG0181@2 NA|NA|NA H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps MAG.T1.179_02154 1211815.CBYP010000047_gene1633 1.1e-96 360.5 Frankiales hemA GO:0005575,GO:0005623,GO:0008150,GO:0009288,GO:0040007,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040 1.2.1.70 ko:K02407,ko:K02492 ko00860,ko01100,ko01110,ko01120,ko02040,map00860,map01100,map01110,map01120,map02040 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000,ko02035 iSB619.SA_RS08420 Bacteria 2GJRA@201174,4ERHS@85013,COG0373@1,COG0373@2 NA|NA|NA H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) MAG.T1.179_02155 1894.JOER01000011_gene2071 4.1e-81 307.8 Actinobacteria Bacteria 2GK4B@201174,COG2197@1,COG2197@2 NA|NA|NA T response regulator MAG.T1.179_02156 1380390.JIAT01000017_gene5376 2.5e-64 252.7 Rubrobacteria iolTA ko:K02058,ko:K10439 ko02010,ko02030,map02010,map02030 M00212,M00221 ko00000,ko00001,ko00002,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 Bacteria 2GKIJ@201174,4CQ39@84995,COG1879@1,COG1879@2 NA|NA|NA G Periplasmic binding protein domain MAG.T1.179_02157 1122939.ATUD01000006_gene1730 6e-90 337.8 Rubrobacteria iolTB ko:K02057,ko:K03466 M00221 ko00000,ko00002,ko02000,ko03036 3.A.1.2,3.A.12 Bacteria 2GM9E@201174,4CPYC@84995,COG1172@1,COG1172@2 NA|NA|NA G Branched-chain amino acid transport system / permease component MAG.T1.179_02158 67257.JODR01000002_gene1060 3.6e-95 354.8 Actinobacteria 3.6.3.17 ko:K02056 M00221 ko00000,ko00002,ko01000,ko02000 3.A.1.2 Bacteria 2GJDV@201174,COG1129@1,COG1129@2 NA|NA|NA G ABC transporter MAG.T1.179_02159 591159.ACEZ01000134_gene2353 1.2e-145 523.5 Actinobacteria cydC ko:K06148,ko:K16012,ko:K16013,ko:K16014 ko02010,map02010 ko00000,ko00001,ko02000 3.A.1,3.A.1.129 Bacteria 2I2DP@201174,COG4987@1,COG4987@2,COG4988@1,COG4988@2 NA|NA|NA V ABC transporter CydDC cysteine exporter (CydDC-E) family permease ATP-binding protein CydD MAG.T1.179_02160 1134445.AJJM01000001_gene2720 1.3e-129 470.3 Actinobacteria cydC ko:K06148,ko:K16012,ko:K16013,ko:K16014 ko02010,map02010 ko00000,ko00001,ko02000 3.A.1,3.A.1.129 Bacteria 2I2DP@201174,COG4987@1,COG4987@2,COG4988@1,COG4988@2 NA|NA|NA V ABC transporter CydDC cysteine exporter (CydDC-E) family permease ATP-binding protein CydD MAG.T1.179_02161 1123320.KB889730_gene6071 1.2e-121 443.7 Actinobacteria Bacteria 2GIWI@201174,COG3850@1,COG3850@2 NA|NA|NA T Histidine kinase MAG.T1.179_02162 35754.JNYJ01000014_gene4724 2.1e-119 435.6 Micromonosporales cydB GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0016682,GO:0019646,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0070069,GO:0071944,GO:0097159,GO:1901363 1.10.3.14 ko:K00426 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 iECABU_c1320.ECABU_c10120,iLF82_1304.LF82_0101,iNRG857_1313.NRG857_04455,iPC815.YPO1118,ic_1306.c1120 Bacteria 2GMFV@201174,4DATV@85008,COG1294@1,COG1294@2 NA|NA|NA C cytochrome d ubiquinol oxidase, subunit MAG.T1.179_02163 469371.Tbis_2750 3.9e-169 601.3 Pseudonocardiales cydA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0016682,GO:0019646,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0070069,GO:0071944,GO:0097159,GO:1901363 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 iPC815.YPO1117,iSBO_1134.SBO_2253,iSFxv_1172.SFxv_0621,iS_1188.S0577,iSbBS512_1146.SbBS512_E2337 Bacteria 2GJE4@201174,4DZRD@85010,COG1271@1,COG1271@2 NA|NA|NA C Cytochrome bd-type quinol oxidase, subunit 1 MAG.T1.179_02164 367299.JOEE01000002_gene2547 1.3e-67 263.5 Intrasporangiaceae 1.1.1.65 ko:K05275 ko00750,ko01100,ko01120,map00750,map01100,map01120 R01708 RC00116 ko00000,ko00001,ko01000 Bacteria 2GJ6R@201174,4FG84@85021,COG0667@1,COG0667@2 NA|NA|NA C Aldo/keto reductase family MAG.T1.179_02165 266940.Krad_3698 4e-50 206.1 Actinobacteria 2.7.13.3,3.1.3.3 ko:K07315,ko:K07654,ko:K07675 ko02020,map02020 M00461,M00473 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko03021 Bacteria 2IHH3@201174,COG2208@1,COG2208@2,COG3850@1,COG3850@2 NA|NA|NA KT stage II sporulation MAG.T1.179_02166 742722.HMPREF9463_00308 1.4e-113 417.2 Coriobacteriia ko:K06147,ko:K12531 ko02020,map02020 M00326 ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.106,3.A.1.109,3.A.1.21 Bacteria 2I6AF@201174,4CUQX@84998,COG5265@1,COG5265@2 NA|NA|NA O ABC transporter MAG.T1.179_02168 749414.SBI_08696 1.4e-69 269.6 Actinobacteria 3.2.1.10,3.2.1.20,3.2.1.93 ko:K01182,ko:K01187,ko:K01226 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00028,R00801,R00802,R00837,R01718,R01791,R06087,R06088,R06113,R06199 RC00028,RC00049,RC00059,RC00077,RC00451 ko00000,ko00001,ko01000 GH13,GH31 Bacteria 2GKS4@201174,COG0366@1,COG0366@2 NA|NA|NA G alpha amylase, catalytic MAG.T1.179_02169 35754.JNYJ01000043_gene4398 8.7e-20 105.1 Micromonosporales Bacteria 2GKG3@201174,4DDUZ@85008,COG2208@1,COG2208@2 NA|NA|NA KT Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) MAG.T1.179_02171 28444.JODQ01000001_gene1881 2.6e-150 538.5 Streptosporangiales chrA ko:K07240 ko00000,ko02000 2.A.51.1 Bacteria 2IB69@201174,4EK6V@85012,COG2059@1,COG2059@2 NA|NA|NA P Chromate transporter MAG.T1.179_02172 1032480.MLP_13020 3.6e-43 181.4 Propionibacteriales Bacteria 2GNA1@201174,4DRXP@85009,COG1695@1,COG1695@2 NA|NA|NA K Transcriptional regulator PadR-like family MAG.T1.179_02173 1125971.ASJB01000080_gene7628 6.2e-65 254.2 Pseudonocardiales lolD ko:K02003 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GM25@201174,4DXIQ@85010,COG1136@1,COG1136@2 NA|NA|NA V ABC-type antimicrobial peptide transport system, ATPase component MAG.T1.179_02174 1033730.CAHG01000016_gene217 4.4e-32 146.0 Propionibacteriales Bacteria 2HZH5@201174,4DSSV@85009,COG0577@1,COG0577@2 NA|NA|NA V efflux transmembrane transporter activity MAG.T1.179_02175 1449069.JMLO01000001_gene1935 9.2e-105 386.3 Nocardiaceae Bacteria 2GMUG@201174,4FZ08@85025,COG2197@1,COG2197@2 NA|NA|NA T cheY-homologous receiver domain MAG.T1.179_02176 1449069.JMLO01000001_gene1936 5.6e-166 590.5 Nocardiaceae Bacteria 2GS7K@201174,4G082@85025,COG4585@1,COG4585@2 NA|NA|NA T Histidine kinase MAG.T1.179_02177 469383.Cwoe_0678 1.1e-57 229.6 Rubrobacteria Bacteria 2ICAF@201174,313GU@2,4CQYQ@84995,arCOG06733@1 NA|NA|NA MAG.T1.179_02178 1306174.JODP01000001_gene4819 5.2e-20 105.9 Bacteria Bacteria COG5555@1,COG5555@2 NA|NA|NA MAG.T1.179_02179 105420.BBPO01000020_gene5614 9.7e-217 759.6 Streptacidiphilus 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 Bacteria 2IA3D@201174,2NI27@228398,COG3119@1,COG3119@2 NA|NA|NA P Sulfatase MAG.T1.179_02180 1996.JOFO01000054_gene1185 2.4e-55 222.6 Streptosporangiales ko:K07052 ko00000 Bacteria 2GMJ1@201174,4EG7A@85012,COG1266@1,COG1266@2 NA|NA|NA S CAAX protease self-immunity MAG.T1.179_02181 985054.JQEZ01000003_gene1066 4.5e-31 142.9 Alphaproteobacteria 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUMZ@1224,2TUKX@28211,COG0457@1,COG0457@2,COG5616@1,COG5616@2 NA|NA|NA T Adenylate cyclase MAG.T1.179_02182 298655.KI912266_gene5611 1.5e-71 276.6 Frankiales ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GN8P@201174,4EV93@85013,COG1131@1,COG1131@2 NA|NA|NA V ABC transporter MAG.T1.179_02183 471853.Bcav_0362 7.2e-19 101.3 Actinobacteria ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2IRIX@201174,COG1277@1,COG1277@2 NA|NA|NA S ABC-type transport system involved in multi-copper enzyme maturation permease component MAG.T1.179_02184 1133850.SHJG_5771 5.3e-15 88.2 Actinobacteria Bacteria 2GKW3@201174,COG1309@1,COG1309@2 NA|NA|NA K Bacterial regulatory proteins, tetR family MAG.T1.179_02185 292564.Cyagr_1692 4.9e-135 487.6 Cyanobacteria arsB GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015104,GO:0015105,GO:0015291,GO:0015297,GO:0015318,GO:0015698,GO:0015699,GO:0015700,GO:0016020,GO:0022804,GO:0022857,GO:0034220,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656 1.20.4.1 ko:K03325,ko:K03741 ko00000,ko01000,ko02000 2.A.59 iYO844.BSU25790 Bacteria 1G05E@1117,COG0798@1,COG0798@2 NA|NA|NA P PFAM Sodium Bile acid symporter family MAG.T1.179_02186 1209989.TepiRe1_2456 1.8e-21 108.2 Thermoanaerobacterales Bacteria 1VEYC@1239,24QMF@186801,42H6Q@68295,COG0526@1,COG0526@2 NA|NA|NA CO redox-active disulfide protein 2 MAG.T1.179_02187 479431.Namu_2554 7.9e-20 102.8 Actinobacteria Bacteria 2GUBI@201174,COG0526@1,COG0526@2 NA|NA|NA CO redox-active disulfide protein 2 MAG.T1.179_02188 479431.Namu_2555 1.6e-146 525.8 Bacteria ko:K07089 ko00000 Bacteria COG0701@1,COG0701@2 NA|NA|NA S Predicted permease MAG.T1.179_02189 1304865.JAGF01000001_gene3289 5.2e-20 103.6 Actinobacteria arsR ko:K03892 ko00000,ko03000 Bacteria 2GQU5@201174,COG0640@1,COG0640@2 NA|NA|NA K PFAM regulatory protein, ArsR MAG.T1.179_02190 1035308.AQYY01000002_gene103 2.9e-24 118.6 Peptococcaceae cdr2 Bacteria 1TPWW@1239,2484C@186801,2606T@186807,COG0446@1,COG0446@2 NA|NA|NA P pyridine nucleotide-disulphide oxidoreductase dimerisation MAG.T1.179_02191 591159.ACEZ01000001_gene6027 5.8e-60 237.7 Actinobacteria glpF ko:K02440,ko:K06188 ko00000,ko02000 1.A.8,1.A.8.1,1.A.8.2 Bacteria 2GMG4@201174,COG0580@1,COG0580@2 NA|NA|NA G Belongs to the MIP aquaporin (TC 1.A.8) family MAG.T1.179_02192 1906.SFRA_16750 5.7e-57 226.9 Actinobacteria arsC 1.20.4.1 ko:K03741 ko00000,ko01000 Bacteria 2IHR3@201174,COG0394@1,COG0394@2 NA|NA|NA T Belongs to the low molecular weight phosphotyrosine protein phosphatase family MAG.T1.179_02193 1121019.AUMN01000033_gene2670 3.7e-42 177.6 Actinobacteria Bacteria 2GPFR@201174,COG4374@1,COG4374@2 NA|NA|NA S PIN domain MAG.T1.179_02194 1380386.JIAW01000031_gene3544 1.3e-19 102.1 Actinobacteria Bacteria 2HD6A@201174,COG2002@1,COG2002@2 NA|NA|NA K toxin-antitoxin pair type II binding MAG.T1.179_02195 477641.MODMU_1575 1.2e-18 98.6 Actinobacteria GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007 Bacteria 2FDS3@1,2GUMT@201174,345T0@2 NA|NA|NA S Evidence 4 Homologs of previously reported genes of MAG.T1.179_02196 1146883.BLASA_1416 5.7e-35 153.3 Actinobacteria mazF5 GO:0008150,GO:0040008,GO:0045926,GO:0048519,GO:0050789,GO:0065007 ko:K07171 ko00000,ko01000,ko02048 Bacteria 2IMGQ@201174,COG2337@1,COG2337@2 NA|NA|NA T Evidence 2b Function of strongly homologous gene MAG.T1.179_02197 1385520.N802_11490 1.4e-25 122.5 Intrasporangiaceae Bacteria 2E8MQ@1,2ISX4@201174,332Z5@2,4FHDD@85021 NA|NA|NA S Ribbon-helix-helix protein, copG family MAG.T1.179_02198 1206732.BAGD01000097_gene4238 5.9e-45 188.0 Nocardiaceae Bacteria 2IMKC@201174,4G03M@85025,COG2021@1,COG2021@2 NA|NA|NA E Serine aminopeptidase, S33 MAG.T1.179_02200 1171373.PACID_01380 2.3e-32 144.8 Actinobacteria ko:K07075 ko00000 Bacteria 2IT4H@201174,COG1669@1,COG1669@2 NA|NA|NA S Nucleotidyltransferase domain MAG.T1.179_02201 1108045.GORHZ_171_00530 2e-22 111.3 Actinobacteria ko:K21495 ko00000,ko02048 Bacteria 2GSHN@201174,COG4691@1,COG4691@2 NA|NA|NA S Plasmid stability protein MAG.T1.179_02202 1121019.AUMN01000003_gene1021 5.8e-52 210.3 Actinobacteria vapC ko:K07062 ko00000,ko01000,ko02048 Bacteria 2IS29@201174,COG1487@1,COG1487@2 NA|NA|NA S Toxic component of a toxin-antitoxin (TA) module. An RNase MAG.T1.179_02203 35754.JNYJ01000011_gene741 2.5e-22 111.3 Micromonosporales yozG ko:K07727 ko00000,ko03000 Bacteria 2GQZM@201174,4DEY7@85008,COG3655@1,COG3655@2 NA|NA|NA K Cro/C1-type HTH DNA-binding domain MAG.T1.179_02204 1043205.AFYF01000045_gene2925 4.7e-08 65.1 Intrasporangiaceae Bacteria 2ET1V@1,2GZYR@201174,33KK0@2,4FI7B@85021 NA|NA|NA S Protein of unknown function (DUF2975) MAG.T1.179_02205 1172179.AUKV01000005_gene5828 3e-24 118.2 Actinobacteria ko:K03088 ko00000,ko03021 Bacteria 2IKVM@201174,COG1595@1,COG1595@2 NA|NA|NA K belongs to the sigma-70 factor family, ECF subfamily MAG.T1.179_02207 455632.SGR_872 2.3e-10 71.6 Actinobacteria ko:K03088 ko00000,ko03021 Bacteria 2IRNG@201174,COG1595@1,COG1595@2 NA|NA|NA K belongs to the sigma-70 factor family, ECF subfamily MAG.T1.179_02209 1128421.JAGA01000002_gene560 3.9e-22 112.1 unclassified Bacteria 3.5.1.106 ko:K15357 ko00760,ko01120,map00760,map01120 M00622 R09126 RC00323,RC02431 ko00000,ko00001,ko00002,ko01000 Bacteria 2NQB7@2323,COG2267@1,COG2267@2 NA|NA|NA I Alpha/beta hydrolase family MAG.T1.179_02210 675635.Psed_2022 3e-79 302.0 Pseudonocardiales Bacteria 2GKX1@201174,4E1RE@85010,COG1718@1,COG1718@2 NA|NA|NA DT Serine threonine protein kinase involved in cell cycle control MAG.T1.179_02211 100226.SCO1348 2.5e-30 138.3 Actinobacteria Bacteria 2CP0Z@1,2IHXV@201174,32SI8@2 NA|NA|NA S Protein of unknown function (DUF3037) MAG.T1.179_02214 754252.PFREUD_17710 9.4e-78 296.6 Actinobacteria Bacteria 2I9IY@201174,COG0739@1,COG0739@2 NA|NA|NA M peptidase MAG.T1.179_02215 593907.Celgi_0077 4.8e-168 597.4 Cellulomonadaceae aspB Bacteria 2GJ7R@201174,4F0IR@85016,COG0436@1,COG0436@2 NA|NA|NA E PFAM aminotransferase class I and II MAG.T1.179_02216 196162.Noca_1363 1.2e-29 136.0 Propionibacteriales Bacteria 2IIQY@201174,4DR4W@85009,COG1917@1,COG1917@2 NA|NA|NA S Cupin 2, conserved barrel domain protein MAG.T1.179_02217 1195236.CTER_0960 1e-13 83.6 Firmicutes ko:K01163 ko00000 Bacteria 1VBBR@1239,COG1670@1,COG1670@2 NA|NA|NA J Acetyltransferase (GNAT) domain MAG.T1.179_02220 1386089.N865_05460 6.2e-56 223.4 Intrasporangiaceae ko:K06996 ko00000 Bacteria 2IRUY@201174,4FGZX@85021,COG3324@1,COG3324@2 NA|NA|NA S PFAM Glyoxalase bleomycin resistance protein dioxygenase MAG.T1.179_02222 134676.ACPL_2692 7e-192 677.2 Micromonosporales Bacteria 28HJF@1,2ICK7@201174,2Z7UK@2,4DAVB@85008 NA|NA|NA MAG.T1.179_02223 479432.Sros_0062 4.6e-70 271.9 Streptosporangiales tetV Bacteria 2GJPT@201174,4EJ0G@85012,COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily MAG.T1.179_02224 1121272.KB903290_gene4678 1.1e-96 360.1 Micromonosporales Bacteria 2C1EG@1,2GK4W@201174,2Z7MZ@2,4DHRJ@85008 NA|NA|NA MAG.T1.179_02225 446466.Cfla_1154 1.2e-226 792.7 Cellulomonadaceae malL 3.2.1.10 ko:K01182 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00801,R01718,R01791,R06199 RC00028,RC00059,RC00077,RC00451 ko00000,ko00001,ko01000 GH13 Bacteria 2GKS4@201174,4F0T5@85016,COG0366@1,COG0366@2 NA|NA|NA G SMART alpha amylase catalytic sub domain MAG.T1.179_02226 1210046.B277_10139 5.4e-175 620.5 Intrasporangiaceae aat3 2.6.1.2,2.6.1.66 ko:K00814,ko:K14260 ko00220,ko00250,ko00290,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00220,map00250,map00290,map00710,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00171 R00258,R01215 RC00006,RC00008,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 2GJ7R@201174,4FFAU@85021,COG0436@1,COG0436@2 NA|NA|NA E in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor MAG.T1.179_02227 1449353.JQMQ01000004_gene6292 4.3e-81 308.5 Streptacidiphilus Bacteria 2GIZ3@201174,2NKDE@228398,COG1814@1,COG1814@2 NA|NA|NA S VIT family MAG.T1.179_02229 408672.NBCG_01400 5.9e-71 275.0 Propionibacteriales 3.2.1.26 ko:K01193 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00801,R00802,R02410,R03635,R03921,R06088 RC00028,RC00077 ko00000,ko00001,ko01000 GH32 Bacteria 2GJ9T@201174,4DS6H@85009,COG1621@1,COG1621@2 NA|NA|NA G Glycosyl hydrolases family 32 MAG.T1.179_02230 1380347.JNII01000008_gene4189 4e-91 342.0 Frankiales ko:K10232 ko02010,map02010 M00201 ko00000,ko00001,ko00002,ko02000 3.A.1.1.32,3.A.1.1.8 Bacteria 2GJXB@201174,4ETQK@85013,COG1653@1,COG1653@2 NA|NA|NA G Bacterial extracellular solute-binding protein MAG.T1.179_02231 1380347.JNII01000008_gene4188 2.9e-102 378.6 Frankiales aglF ko:K02025,ko:K10233,ko:K15771 ko02010,map02010 M00201,M00207,M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.2,3.A.1.1.32,3.A.1.1.8 Bacteria 2GKYS@201174,4EV1G@85013,COG1175@1,COG1175@2 NA|NA|NA G Binding-protein-dependent transport system inner membrane component MAG.T1.179_02232 1380347.JNII01000008_gene4187 2.6e-97 362.1 Frankiales aglG ko:K02026,ko:K10234 ko02010,map02010 M00201,M00207 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.32,3.A.1.1.8 Bacteria 2GJNN@201174,4EUW8@85013,COG0395@1,COG0395@2 NA|NA|NA P Binding-protein-dependent transport system inner membrane component MAG.T1.179_02234 288705.RSal33209_0444 5.8e-136 490.7 Micrococcaceae ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 ko00000,ko00001,ko00002,ko02000 3.A.1.1 Bacteria 1W80X@1268,2GJCM@201174,COG3842@1,COG3842@2 NA|NA|NA E ABC transporter MAG.T1.179_02235 1246995.AFR_16520 1.5e-140 506.9 Micromonosporales 2.4.1.12 ko:K00694 ko00500,ko01100,ko02026,map00500,map01100,map02026 R02889 RC00005 ko00000,ko00001,ko01000,ko01003,ko02000 4.D.3.1.2,4.D.3.1.5,4.D.3.1.6 GT2 Bacteria 2GKFI@201174,4D8PJ@85008,COG1215@1,COG1215@2 NA|NA|NA M Glycosyltransferases, probably involved in cell wall biogenesis MAG.T1.179_02236 1089545.KB913037_gene8298 6.2e-33 149.4 Pseudonocardiales ko:K03556 ko00000,ko03000 Bacteria 2IBM2@201174,4E973@85010,COG2197@1,COG2197@2,COG2909@1,COG2909@2 NA|NA|NA KT helix_turn_helix, Lux Regulon MAG.T1.179_02237 1961.JOAK01000019_gene6876 1e-113 417.2 Actinobacteria nagE 2.7.1.193,2.7.1.199 ko:K02803,ko:K02804,ko:K20116,ko:K20117,ko:K20118 ko00010,ko00520,ko02060,map00010,map00520,map02060 M00267,M00809 R02738,R05199 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.13,4.A.1.1.14,4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7,4.A.1.1.9 Bacteria 2GKPM@201174,COG1263@1,COG1263@2 NA|NA|NA G Phosphotransferase System MAG.T1.179_02238 290399.Arth_3515 1.1e-17 95.5 Actinobacteria 2.7.1.193 ko:K02803 ko00520,ko02060,map00520,map02060 M00267 R05199 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7 Bacteria 2IQIB@201174,COG1264@1,COG1264@2 NA|NA|NA G phosphotransferase system MAG.T1.179_02239 1120950.KB892832_gene4019 2.4e-78 298.9 Propionibacteriales ko:K06384 ko00000 Bacteria 2GJTG@201174,4DNR1@85009,COG1300@1,COG1300@2 NA|NA|NA S Stage II sporulation protein M MAG.T1.179_02240 1125971.ASJB01000080_gene7656 1.3e-51 210.3 Pseudonocardiales Bacteria 2H4MP@201174,4E2SC@85010,COG1714@1,COG1714@2 NA|NA|NA S RDD family MAG.T1.179_02241 269800.Tfu_2505 6e-226 790.0 Streptosporangiales ahcY GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 Bacteria 2GK2Q@201174,4EIAX@85012,COG0499@1,COG0499@2 NA|NA|NA H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine MAG.T1.179_02242 134676.ACPL_1062 1.7e-91 342.8 Micromonosporales cat Bacteria 2GKSG@201174,4DAPD@85008,COG0053@1,COG0053@2 NA|NA|NA P cation diffusion facilitator family transporter MAG.T1.179_02243 298654.FraEuI1c_6060 2.8e-13 80.9 Frankiales ycaR GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 2.7.1.130 ko:K00912,ko:K09791 ko00540,ko01100,map00540,map01100 M00060 R04657 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 Bacteria 2HUT6@201174,4ETHY@85013,COG2835@1,COG2835@2 NA|NA|NA S Trm112p-like protein MAG.T1.179_02244 471852.Tcur_4063 2e-170 605.5 Streptosporangiales manB GO:0003674,GO:0003824,GO:0004615,GO:0005975,GO:0008150,GO:0008152,GO:0016853,GO:0016866,GO:0016868,GO:0044238,GO:0071704 5.4.2.2,5.4.2.8 ko:K01840,ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 iECS88_1305.ECS88_2145,iECUMN_1333.ECUMN_2384,iUTI89_1310.UTI89_C2321 Bacteria 2GJQA@201174,4EGWS@85012,COG1109@1,COG1109@2 NA|NA|NA G Phosphoglucomutase/phosphomannomutase, C-terminal domain MAG.T1.179_02245 1380346.JNIH01000014_gene897 1.3e-39 169.1 Actinobacteria Bacteria 2C7XW@1,2IQ5R@201174,32RR4@2 NA|NA|NA S Protein of unknown function (DUF3499) MAG.T1.179_02246 1120950.KB892759_gene6287 4.4e-33 149.4 Propionibacteriales dedD ko:K02520,ko:K03749,ko:K06204,ko:K16291 ko02026,map02026 ko00000,ko00001,ko01002,ko01011,ko03000,ko03009,ko03012,ko03021,ko03029 Bacteria 2HC8A@201174,4DRQT@85009,COG3147@1,COG3147@2 NA|NA|NA S Non-essential cell division protein that could be required for efficient cell constriction MAG.T1.179_02247 1463864.JOGO01000058_gene3814 5.9e-90 339.3 Actinobacteria Bacteria 2GIUN@201174,COG1216@1,COG1216@2 NA|NA|NA M PFAM Glycosyl transferase family 2 MAG.T1.179_02248 1122622.ATWJ01000015_gene620 4e-32 143.7 Intrasporangiaceae whiB2 ko:K18955 ko00000,ko03000 Bacteria 2CC1Y@1,2IQ4Q@201174,32RUK@2,4FHAS@85021 NA|NA|NA K Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA MAG.T1.179_02250 1449355.JQNR01000005_gene2189 3e-69 268.9 Actinobacteria 3.2.2.21 ko:K01247 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 2GP69@201174,COG0122@1,COG0122@2 NA|NA|NA L 3-methyladenine DNA glycosylase MAG.T1.179_02251 1079986.JH164840_gene4710 2e-117 429.1 Actinobacteria manC 2.7.7.13,5.4.2.8 ko:K00966,ko:K16881 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114,M00361,M00362 R00885,R01818 RC00002,RC00408 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKTE@201174,COG1208@1,COG1208@2 NA|NA|NA JM Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B gamma epsilon subunits MAG.T1.179_02252 1463857.JOFZ01000018_gene1431 1.8e-18 99.8 Actinobacteria Bacteria 2GIX4@201174,COG0318@1,COG0318@2 NA|NA|NA IQ COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases MAG.T1.179_02253 1306174.JODP01000001_gene4657 1.6e-60 241.5 Actinobacteria Bacteria 2GNDB@201174,COG4102@1,COG4102@2,COG5479@1,COG5479@2 NA|NA|NA M N-acetylmuramoyl-L-alanine amidase MAG.T1.179_02254 266940.Krad_0030 1.6e-74 287.0 Actinobacteria Bacteria 2GJM3@201174,COG1316@1,COG1316@2 NA|NA|NA K cell envelope-related transcriptional attenuator MAG.T1.179_02255 1996.JOFO01000004_gene3449 1.2e-98 366.3 Streptosporangiales 2.8.3.5 ko:K01028 ko00072,ko00280,ko00650,map00072,map00280,map00650 R00410 RC00014 ko00000,ko00001,ko01000 Bacteria 2GK61@201174,4EHWM@85012,COG1788@1,COG1788@2 NA|NA|NA I Coenzyme A transferase MAG.T1.179_02256 1996.JOFO01000004_gene3448 3.3e-91 341.3 Streptosporangiales scoB 2.8.3.5 ko:K01029 ko00072,ko00280,ko00650,map00072,map00280,map00650 R00410 RC00014 ko00000,ko00001,ko01000 Bacteria 2GKV9@201174,4EI8M@85012,COG2057@1,COG2057@2 NA|NA|NA I Coenzyme A transferase MAG.T1.179_02257 110663.KI911558_gene1353 6.7e-10 70.9 Synechococcus ste14 Bacteria 1G67D@1117,1H0KJ@1129,COG2020@1,COG2020@2 NA|NA|NA O Isoprenylcysteine carboxyl methyltransferase (ICMT) family MAG.T1.179_02258 909613.UO65_5851 1.4e-96 360.1 Actinobacteria Bacteria 2H6EP@201174,COG1887@1,COG1887@2 NA|NA|NA M Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC MAG.T1.179_02259 935839.JAGJ01000002_gene821 2e-78 298.9 Actinobacteria phnW 2.6.1.37,2.7.7.74,2.7.8.12 ko:K03430,ko:K07281,ko:K09809 ko00440,ko00562,ko01100,ko01120,map00440,map00562,map01100,map01120 R04152,R09669 RC00002,RC00008,RC00062 ko00000,ko00001,ko01000,ko01007 Bacteria 2GN1Y@201174,COG1213@1,COG1213@2 NA|NA|NA M transferase MAG.T1.179_02260 1120959.ATXF01000010_gene75 5.4e-100 370.9 Microbacteriaceae GO:0003674,GO:0003824,GO:0016740,GO:0016757 ko:K07011 ko00000 Bacteria 2GK2D@201174,4FMHT@85023,COG1216@1,COG1216@2 NA|NA|NA S Glycosyl transferase family 2 MAG.T1.179_02261 1348338.ADILRU_1958 4.6e-74 284.6 Microbacteriaceae Bacteria 2GN3C@201174,4FKEI@85023,COG0558@1,COG0558@2 NA|NA|NA I CDP-alcohol phosphatidyltransferase MAG.T1.179_02262 1123320.KB889669_gene3225 2.6e-56 226.9 Actinobacteria Bacteria 2GKG1@201174,COG0558@1,COG0558@2 NA|NA|NA I Belongs to the CDP-alcohol phosphatidyltransferase class-I family MAG.T1.179_02263 1394178.AWOO02000005_gene3524 2.1e-111 409.1 Streptosporangiales exoA Bacteria 2GMWF@201174,4EHSA@85012,COG1215@1,COG1215@2 NA|NA|NA M Glycosyl transferase family 21 MAG.T1.179_02265 1449347.JQLN01000007_gene1076 7.6e-138 497.3 Kitasatospora ypeA ko:K13525 ko04141,ko05134,map04141,map05134 M00400,M00403 ko00000,ko00001,ko00002,ko03019,ko04131,ko04147 3.A.16.1 Bacteria 2GJ07@201174,2M4MQ@2063,COG0454@1,COG0456@2,COG0464@1,COG0464@2 NA|NA|NA KO ATPase family associated with various cellular activities (AAA) MAG.T1.179_02266 398578.Daci_5504 5.7e-49 200.3 Comamonadaceae mscL GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 ko:K03282 ko00000,ko02000 1.A.22.1 Bacteria 1RHG8@1224,2VT9K@28216,4ADW1@80864,COG1970@1,COG1970@2 NA|NA|NA M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell MAG.T1.179_02267 585531.HMPREF0063_11453 1e-89 336.7 Propionibacteriales punA GO:0003674,GO:0003824,GO:0004731,GO:0006139,GO:0006152,GO:0006161,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009116,GO:0009120,GO:0009164,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0019439,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042453,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046121,GO:0046122,GO:0046124,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658 2.4.2.1 ko:K03783 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244 RC00033,RC00063,RC00122 ko00000,ko00001,ko01000 Bacteria 2GKEI@201174,4DMXP@85009,COG0005@1,COG0005@2 NA|NA|NA F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate MAG.T1.179_02268 471852.Tcur_4181 2.4e-47 194.9 Streptosporangiales ykqA Bacteria 2GJM9@201174,4EIZE@85012,COG3703@1,COG3703@2 NA|NA|NA P AIG2-like family MAG.T1.179_02269 397278.JOJN01000001_gene2858 4.7e-159 567.8 Propionibacteriales lpdA GO:0000166,GO:0003674,GO:0003824,GO:0003955,GO:0005488,GO:0008150,GO:0008152,GO:0009405,GO:0016491,GO:0016651,GO:0016655,GO:0036094,GO:0043167,GO:0043168,GO:0044419,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0051704,GO:0055114,GO:0070401,GO:0097159,GO:1901265,GO:1901363 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GMP7@201174,4DNPF@85009,COG1249@1,COG1249@2 NA|NA|NA C Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain MAG.T1.179_02270 479433.Caci_0809 2.2e-249 868.2 Actinobacteria bccA 6.3.4.14,6.4.1.2,6.4.1.3 ko:K11263 ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00741 R00742,R01859,R04385 RC00040,RC00097,RC00253,RC00367,RC00609 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIZP@201174,COG4770@1,COG4770@2 NA|NA|NA I carboxylase MAG.T1.179_02271 2074.JNYD01000012_gene432 3.6e-48 198.4 Pseudonocardiales maf GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0030312,GO:0036218,GO:0036221,GO:0042802,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0047429,GO:0071944 1.1.1.25,2.1.1.190 ko:K00014,ko:K03215,ko:K06287 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000,ko03009 Bacteria 2GNI0@201174,4E2ME@85010,COG0424@1,COG0424@2 NA|NA|NA D Maf-like protein MAG.T1.179_02272 1298860.AUEM01000003_gene3722 2.2e-17 97.8 Microbacteriaceae 2.4.1.52 ko:K00712 ko00000,ko01000,ko01003 GT4 Bacteria 2GJBP@201174,4FNSK@85023,COG0438@1,COG0438@2 NA|NA|NA M Glycosyl transferases group 1 MAG.T1.179_02274 235985.BBPN01000058_gene7572 1.8e-231 808.5 Streptacidiphilus pccB 2.1.3.15,6.4.1.3 ko:K01966 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIRU@201174,2NGRN@228398,COG4799@1,COG4799@2 NA|NA|NA I Carboxyl transferase domain MAG.T1.179_02275 1957.JODX01000002_gene4462 4.8e-46 191.8 Actinobacteria birA GO:0000166,GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004077,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009305,GO:0009374,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0017053,GO:0017076,GO:0017144,GO:0018130,GO:0018271,GO:0019538,GO:0019752,GO:0019842,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032991,GO:0033218,GO:0033293,GO:0034641,GO:0035639,GO:0036094,GO:0036211,GO:0042364,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043565,GO:0043603,GO:0043604,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1990837 2.7.1.33,6.3.4.15 ko:K01947,ko:K03524 ko00770,ko00780,ko01100,map00770,map00780,map01100 M00120 R01074,R02971,R03018,R04391,R05145 RC00002,RC00017,RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko00002,ko01000,ko03000 Bacteria 2GN8Q@201174,COG0340@1,COG0340@2 NA|NA|NA H biotin lipoate A B protein ligase MAG.T1.179_02276 500153.JOEK01000003_gene1233 4.5e-58 231.9 Actinobacteria cya 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 Bacteria 2GN02@201174,COG2114@1,COG2114@2 NA|NA|NA T PFAM Adenylyl cyclase class-3 4 guanylyl cyclase MAG.T1.179_02277 1048339.KB913029_gene20 6.5e-39 167.2 Frankiales ko:K07015 ko00000 Bacteria 2IFFV@201174,4ET34@85013,COG2246@1,COG2246@2 NA|NA|NA S PFAM GtrA family protein MAG.T1.179_02278 1050202.KB913024_gene29 5.1e-151 540.8 Actinopolysporales acdA GO:0000062,GO:0000166,GO:0003674,GO:0003824,GO:0003995,GO:0004085,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005759,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009605,GO:0009719,GO:0009725,GO:0009987,GO:0009991,GO:0010033,GO:0014070,GO:0016020,GO:0016042,GO:0016043,GO:0016054,GO:0016491,GO:0016627,GO:0017076,GO:0019395,GO:0019605,GO:0019626,GO:0019752,GO:0022607,GO:0030258,GO:0030554,GO:0031090,GO:0031667,GO:0031960,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033218,GO:0033539,GO:0033993,GO:0034440,GO:0036094,GO:0042221,GO:0042594,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046359,GO:0046395,GO:0046459,GO:0048037,GO:0048545,GO:0050660,GO:0050662,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051384,GO:0052890,GO:0055114,GO:0065003,GO:0070013,GO:0071704,GO:0071840,GO:0072329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901567,GO:1901575,GO:1901681 1.3.8.1 ko:K00248,ko:K18244 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 Bacteria 2GMEM@201174,407ZG@622450,COG1960@1,COG1960@2 NA|NA|NA I Acyl-CoA dehydrogenase, C-terminal domain MAG.T1.179_02279 469383.Cwoe_5648 7.3e-58 231.1 Rubrobacteria 5.1.3.3 ko:K01785 ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130 M00632 R01602,R10619 RC00563 ko00000,ko00001,ko00002,ko01000 Bacteria 2HQKA@201174,4CS5Q@84995,COG2017@1,COG2017@2 NA|NA|NA G Aldose 1-epimerase MAG.T1.179_02280 1048339.KB913029_gene1756 9.1e-37 160.6 Actinobacteria Bacteria 28IGY@1,2H6U5@201174,2Z8I9@2 NA|NA|NA MAG.T1.179_02281 879212.DespoDRAFT_01603 7.8e-45 187.6 Desulfobacterales gluQ 6.1.1.17 ko:K01885,ko:K01894 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 Bacteria 1MUN7@1224,2MNAB@213118,2WV4B@28221,42NQ8@68525,COG0008@1,COG0008@2 NA|NA|NA J Belongs to the class-I aminoacyl-tRNA synthetase family MAG.T1.179_02282 479435.Kfla_1567 1.1e-83 317.0 Propionibacteriales tagH 3.6.3.38,3.6.3.40 ko:K09689,ko:K09691,ko:K09693 ko02010,map02010 M00249,M00250,M00251 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.101,3.A.1.103,3.A.1.104 Bacteria 2GIVF@201174,4DPY7@85009,COG1134@1,COG1134@2 NA|NA|NA GM ATPases associated with a variety of cellular activities MAG.T1.179_02283 2002.JOEQ01000052_gene8351 7.1e-76 290.8 Streptosporangiales tagG ko:K09690,ko:K09692 ko02010,map02010 M00250,M00251 ko00000,ko00001,ko00002,ko02000 3.A.1.103,3.A.1.104 Bacteria 2GP5K@201174,4EHWE@85012,COG1682@1,COG1682@2 NA|NA|NA GM ABC-2 type transporter MAG.T1.179_02284 1123320.KB889719_gene7401 3.9e-127 461.5 Actinobacteria purK GO:0000166,GO:0003674,GO:0003824,GO:0004638,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016829,GO:0016830,GO:0016831,GO:0016874,GO:0016879,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034028,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.4.18 ko:K01589 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07404 RC01927 ko00000,ko00001,ko00002,ko01000 iECUMN_1333.ECUMN_0562,iYL1228.KPN_00477 Bacteria 2GJCU@201174,COG0026@1,COG0026@2 NA|NA|NA F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) MAG.T1.179_02285 1896.JOAU01000015_gene2030 2.1e-59 235.3 Actinobacteria purE GO:0008150,GO:0040007 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 iJN678.purE,iNJ661.Rv3275c Bacteria 2IFFD@201174,COG0041@1,COG0041@2 NA|NA|NA F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) MAG.T1.179_02286 1463936.JOJI01000050_gene5841 9e-163 580.1 Actinobacteria ugd 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJQB@201174,COG1004@1,COG1004@2 NA|NA|NA M Belongs to the UDP-glucose GDP-mannose dehydrogenase family MAG.T1.179_02287 446468.Ndas_4413 2.1e-152 545.4 Streptosporangiales 1.3.8.1,1.3.8.7 ko:K00248,ko:K00249 ko00071,ko00280,ko00410,ko00640,ko00650,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map00650,map01100,map01110,map01120,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01178,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00120,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIX8@201174,4EHDP@85012,COG1960@1,COG1960@2 NA|NA|NA I Acyl-CoA dehydrogenase, middle domain MAG.T1.179_02288 1078020.KEK_14488 0.0 2290.4 Mycobacteriaceae recD2_4 Bacteria 2382F@1762,2GKJW@201174,COG0507@1,COG0507@2,COG1112@1,COG1112@2 NA|NA|NA L Protein of unknown function (DUF4011) MAG.T1.179_02289 272844.PAB2253 2.7e-33 149.4 Thermococci pgk2 ko:K05715 R02664 RC00002,RC00017 ko00000,ko01000 Archaea 242Y8@183968,2XVZC@28890,COG2074@1,arCOG01967@2157 NA|NA|NA F 2-phosphoglycerate kinase MAG.T1.179_02290 1504319.GM45_4290 2.3e-186 658.7 unclassified Actinobacteria (class) gltX GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 iNJ661.Rv2992c Bacteria 2GJJS@201174,3UW9W@52018,COG0008@1,COG0008@2 NA|NA|NA J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) MAG.T1.179_02291 981369.JQMJ01000004_gene5700 3.4e-82 311.6 Streptacidiphilus fahA Bacteria 2GN2G@201174,2NF0A@228398,COG0179@1,COG0179@2 NA|NA|NA Q Domain of unknown function (DUF2437) MAG.T1.179_02292 1155718.KB891889_gene6846 4.3e-204 717.6 Actinobacteria cimA 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2GKYT@201174,COG0119@1,COG0119@2 NA|NA|NA E Belongs to the alpha-IPM synthase homocitrate synthase family MAG.T1.179_02293 1123322.KB904660_gene1100 1.7e-141 509.2 Actinobacteria ilvE GO:0000082,GO:0000096,GO:0000097,GO:0000278,GO:0003674,GO:0003824,GO:0004084,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0006082,GO:0006464,GO:0006520,GO:0006551,GO:0006555,GO:0006573,GO:0006790,GO:0006807,GO:0007049,GO:0008144,GO:0008150,GO:0008152,GO:0008283,GO:0008483,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009067,GO:0009081,GO:0009082,GO:0009083,GO:0009086,GO:0009098,GO:0009099,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016769,GO:0017144,GO:0018065,GO:0018193,GO:0018205,GO:0018272,GO:0018352,GO:0019538,GO:0019752,GO:0019842,GO:0022402,GO:0030170,GO:0036094,GO:0036211,GO:0040007,GO:0043094,GO:0043102,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044770,GO:0044772,GO:0044843,GO:0046394,GO:0046395,GO:0048037,GO:0050662,GO:0070279,GO:0071265,GO:0071267,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901607,GO:1903047 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 2GKJ1@201174,COG0115@1,COG0115@2 NA|NA|NA E Branched-chain amino acid aminotransferase MAG.T1.179_02294 469371.Tbis_2812 3.9e-134 484.6 Pseudonocardiales leuB GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044464,GO:0055114 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2GK44@201174,4DXBP@85010,COG0473@1,COG0473@2 NA|NA|NA CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate MAG.T1.179_02295 1288083.AUKR01000014_gene2876 3.9e-109 402.5 Actinobacteria Bacteria 2GKI5@201174,COG1835@1,COG1835@2 NA|NA|NA I Acyltransferase MAG.T1.179_02296 526225.Gobs_0501 6.2e-249 866.7 Frankiales leuA GO:0000287,GO:0003674,GO:0003824,GO:0003852,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0019752,GO:0030145,GO:0030955,GO:0031420,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0046912,GO:0046914,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2GISX@201174,4ERVK@85013,COG0119@1,COG0119@2 NA|NA|NA E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) MAG.T1.179_02297 1380354.JIAN01000008_gene3362 5.1e-64 252.3 Actinobacteria 3.2.1.91 ko:K19668 ko00500,ko01100,ko02020,map00500,map01100,map02020 R02886,R11308 RC00799 ko00000,ko00001,ko01000 GH6 Bacteria 2GN7G@201174,COG3291@1,COG3291@2,COG3420@1,COG3420@2 NA|NA|NA P PFAM PKD domain containing protein MAG.T1.179_02298 31964.CMS2390 9.4e-72 277.3 Microbacteriaceae gumI 2.4.1.251 ko:K13658 R09734 RC00005,RC00049 ko00000,ko01000,ko01003 Bacteria 2IAJJ@201174,4FMGW@85023,COG0438@1,COG0438@2 NA|NA|NA M Glycosyl transferases group 1 MAG.T1.179_02299 590998.Celf_3048 2.6e-29 136.3 Actinobacteria rlpA ko:K03642,ko:K03749 ko00000 Bacteria 2I8WA@201174,COG3147@1,COG3147@2 NA|NA|NA N Non-essential cell division protein that could be required for efficient cell constriction MAG.T1.179_02300 1380354.JIAN01000008_gene3362 1.8e-39 170.6 Actinobacteria 3.2.1.91 ko:K19668 ko00500,ko01100,ko02020,map00500,map01100,map02020 R02886,R11308 RC00799 ko00000,ko00001,ko01000 GH6 Bacteria 2GN7G@201174,COG3291@1,COG3291@2,COG3420@1,COG3420@2 NA|NA|NA P PFAM PKD domain containing protein MAG.T1.179_02301 590998.Celf_3045 6e-70 271.2 Bacteria 2.4.1.289 ko:K07011,ko:K16870 ko00000,ko01000,ko01003 Bacteria COG1216@1,COG1216@2 NA|NA|NA V Glycosyl transferase, family 2 MAG.T1.179_02302 590998.Celf_3040 3.5e-28 132.1 Bacteria Bacteria 2EFAB@1,33939@2 NA|NA|NA MAG.T1.179_02303 443906.CMM_0825 0.0 1305.0 Microbacteriaceae Bacteria 2GN7G@201174,4FKX3@85023,COG3291@1,COG3291@2 NA|NA|NA G Repeats in polycystic kidney disease 1 (PKD1) and other proteins MAG.T1.179_02304 1150399.AQYK01000002_gene3211 1.6e-71 276.9 Microbacteriaceae Bacteria 2CD7Z@1,2GNGQ@201174,30EQS@2,4FNRW@85023 NA|NA|NA MAG.T1.179_02305 590998.Celf_3032 2.3e-92 346.3 Cellulomonadaceae wcoI 2.7.10.2 ko:K08253,ko:K16692 ko00000,ko01000,ko01001 Bacteria 2GJ1Y@201174,4F2TG@85016,COG0489@1,COG0489@2,COG3944@1,COG3944@2 NA|NA|NA M PFAM lipopolysaccharide biosynthesis protein MAG.T1.179_02306 1121924.ATWH01000001_gene4304 1.2e-118 433.7 Microbacteriaceae gumJ ko:K03328 ko00000 2.A.66.2 Bacteria 2H55P@201174,4FM0V@85023,COG2244@1,COG2244@2 NA|NA|NA M Polysaccharide biosynthesis protein MAG.T1.179_02308 397278.JOJN01000001_gene2897 2e-170 605.5 Propionibacteriales fliI GO:0003674,GO:0005488,GO:0005515,GO:0042802 3.6.3.14 ko:K02412,ko:K03224 ko02040,ko03070,map02040,map03070 M00332,M00542,M00660 ko00000,ko00001,ko00002,ko01000,ko02035,ko02044 3.A.6.1,3.A.6.2,3.A.6.3 Bacteria 2GKGV@201174,4DPDQ@85009,COG1157@1,COG1157@2 NA|NA|NA NU ATP synthase alpha/beta family, nucleotide-binding domain MAG.T1.179_02309 196162.Noca_0757 1.2e-22 113.6 Propionibacteriales fliH ko:K02411,ko:K03223 ko02040,ko03070,map02040,map03070 M00332,M00660 ko00000,ko00001,ko00002,ko02035,ko02044 3.A.6.1,3.A.6.2,3.A.6.3 Bacteria 2IRIT@201174,4DRP3@85009,COG1317@1,COG1317@2 NA|NA|NA NU Flagellar biosynthesis type III secretory pathway MAG.T1.179_02310 1283287.KB822581_gene1476 9.8e-117 426.8 Propionibacteriales fliG GO:0001539,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006928,GO:0006935,GO:0006996,GO:0008150,GO:0009288,GO:0009425,GO:0009605,GO:0009987,GO:0016020,GO:0016043,GO:0022607,GO:0030030,GO:0030031,GO:0040011,GO:0042221,GO:0042330,GO:0042802,GO:0042803,GO:0042995,GO:0043226,GO:0043228,GO:0044085,GO:0044403,GO:0044419,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0044780,GO:0044781,GO:0046982,GO:0046983,GO:0048870,GO:0050896,GO:0051179,GO:0051674,GO:0051701,GO:0051704,GO:0052116,GO:0052126,GO:0052127,GO:0052143,GO:0052192,GO:0052195,GO:0052216,GO:0052243,GO:0070925,GO:0071840,GO:0071944,GO:0071973,GO:0071978,GO:0097588 ko:K02410 ko02030,ko02040,map02030,map02040 ko00000,ko00001,ko02035 Bacteria 2GP1H@201174,4DP5X@85009,COG1536@1,COG1536@2 NA|NA|NA N FliG N-terminal domain MAG.T1.179_02311 196162.Noca_0759 1.4e-135 490.0 Propionibacteriales fliF ko:K02409 ko02040,map02040 ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 Bacteria 2HG9F@201174,4DP5G@85009,COG1766@1,COG1766@2 NA|NA|NA NU Flagellar M-ring protein C-terminal MAG.T1.179_02312 196162.Noca_0760 1.2e-23 115.9 Propionibacteriales fliE GO:0005575,GO:0005623,GO:0009288,GO:0009425,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464 ko:K02408 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 2GR0F@201174,4DSFF@85009,COG1677@1,COG1677@2 NA|NA|NA NU Flagellar hook-basal body complex protein FliE MAG.T1.179_02313 1298863.AUEP01000003_gene2837 4.8e-40 170.6 Propionibacteriales flgC GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009424,GO:0009425,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588 ko:K02388 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 2IKRZ@201174,4DR9V@85009,COG1558@1,COG1558@2 NA|NA|NA N Flagellar basal body rod FlgEFG protein C-terminal MAG.T1.179_02314 196162.Noca_0762 7.2e-27 126.7 Propionibacteriales flgB ko:K02387 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 2IQWB@201174,4DUZX@85009,COG1815@1,COG1815@2 NA|NA|NA N Flagella basal body rod protein MAG.T1.179_02316 526225.Gobs_0983 7.6e-27 126.7 Frankiales fliS GO:0001539,GO:0003674,GO:0005198,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588 ko:K02422 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 2IRX7@201174,4ET7K@85013,COG1516@1,COG1516@2 NA|NA|NA N flagellar protein FliS MAG.T1.179_02317 1298863.AUEP01000003_gene2841 1.4e-91 343.6 Propionibacteriales fliD GO:0001539,GO:0003674,GO:0005198,GO:0005575,GO:0005576,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009420,GO:0009421,GO:0009424,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588 ko:K02407 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 2IBVB@201174,4DP7F@85009,COG1345@1,COG1345@2 NA|NA|NA N Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end MAG.T1.179_02318 935866.JAER01000069_gene1411 5.7e-109 400.6 Propionibacteriales fliC ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 ko00000,ko00001,ko02035 Bacteria 2GUKT@201174,4DP5T@85009,COG1344@1,COG1344@2 NA|NA|NA N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella MAG.T1.179_02319 935866.JAER01000071_gene1360 3e-90 338.6 Propionibacteriales fliA 2.7.11.1 ko:K02405,ko:K12132 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 ko00000,ko00001,ko01000,ko01001,ko02035,ko03021 Bacteria 2GKBK@201174,4DP9I@85009,COG1191@1,COG1191@2 NA|NA|NA K RNA polymerase, sigma 28 subunit, SigD FliA WhiG MAG.T1.179_02323 404589.Anae109_0594 1.1e-63 250.4 Deltaproteobacteria cyeA Bacteria 1MZQM@1224,2WRK6@28221,42VPN@68525,COG0697@1,COG0697@2 NA|NA|NA EG EamA-like transporter family MAG.T1.179_02324 33898.JRHJ01000076_gene172 2.7e-46 191.4 Actinobacteria ko:K04750 ko00000 Bacteria 2IKY5@201174,COG2764@1,COG2764@2 NA|NA|NA S glyoxalase bleomycin resistance protein dioxygenase MAG.T1.179_02325 314345.SPV1_05173 2.9e-95 355.9 Proteobacteria Bacteria 1NV1F@1224,COG2199@1,COG2199@2 NA|NA|NA T ggdef domain MAG.T1.179_02326 43354.JOIJ01000011_gene2664 2.2e-120 439.9 Pseudonocardiales Bacteria 2GKI5@201174,4DYJ7@85010,COG1835@1,COG1835@2 NA|NA|NA I PFAM Acyltransferase MAG.T1.179_02327 1033730.CAHG01000016_gene637 5.8e-62 244.2 Propionibacteriales dsbA Bacteria 2GNBC@201174,4DQ7I@85009,COG2761@1,COG2761@2 NA|NA|NA Q DSBA-like thioredoxin domain MAG.T1.179_02328 1304865.JAGF01000001_gene735 2.9e-118 431.8 Cellulomonadaceae ddhD Bacteria 2GKW0@201174,4F0TD@85016,COG0673@1,COG0673@2 NA|NA|NA S PFAM oxidoreductase domain protein MAG.T1.179_02329 1454010.JEOE01000011_gene2396 7.7e-129 468.0 Actinobacteria Bacteria 2IBWT@201174,COG4425@1,COG4425@2 NA|NA|NA S Alpha/beta-hydrolase family MAG.T1.179_02330 1043493.BBLU01000007_gene25 2.8e-191 674.9 Actinobacteria ugp 2.7.7.9 ko:K00963 ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130 M00129,M00361,M00362,M00549 R00289 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 2I2G3@201174,COG4284@1,COG4284@2 NA|NA|NA G UTP-glucose-1-phosphate uridylyltransferase MAG.T1.179_02331 1380354.JIAN01000008_gene3362 1.9e-29 136.7 Actinobacteria 3.2.1.91 ko:K19668 ko00500,ko01100,ko02020,map00500,map01100,map02020 R02886,R11308 RC00799 ko00000,ko00001,ko01000 GH6 Bacteria 2GN7G@201174,COG3291@1,COG3291@2,COG3420@1,COG3420@2 NA|NA|NA P PFAM PKD domain containing protein MAG.T1.179_02332 397278.JOJN01000002_gene388 3e-19 101.3 Propionibacteriales lsr Bacteria 2C4MW@1,2IQ6A@201174,32RKK@2,4DRM6@85009 NA|NA|NA S Lsr2 MAG.T1.179_02333 1121272.KB903249_gene2195 4e-11 76.3 Micromonosporales Bacteria 2B1IP@1,2GT98@201174,31TZW@2,4DG21@85008 NA|NA|NA S RDD family MAG.T1.179_02334 76636.JOEC01000002_gene2779 7.1e-15 85.9 Microbacteriaceae ko:K09946 ko00000 Bacteria 2GQUP@201174,4FQ8G@85023,COG3422@1,COG3422@2 NA|NA|NA S Domain of unknown function (DUF1508) MAG.T1.179_02338 1283283.ATXA01000002_gene2554 1.5e-15 87.8 Frankiales rplS GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02884 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IHRT@201174,4ESVQ@85013,COG0335@1,COG0335@2 NA|NA|NA J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site MAG.T1.179_02339 1203568.HMPREF1484_00113 2.8e-33 148.7 Dermabacteraceae 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 ko00000,ko00001,ko01000,ko01002 Bacteria 2GIYN@201174,4FCW9@85020,COG0681@1,COG0681@2 NA|NA|NA U Signal peptidase, peptidase S26 MAG.T1.179_02340 1155718.KB891909_gene1213 2.4e-54 218.8 Actinobacteria lepB GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 ko00000,ko00001,ko01000,ko01002 Bacteria 2GIYN@201174,COG0681@1,COG0681@2 NA|NA|NA U Belongs to the peptidase S26 family MAG.T1.179_02341 1304865.JAGF01000001_gene3835 9.6e-66 256.9 Cellulomonadaceae rnhB GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 ko:K03470 ko03030,map03030 ko00000,ko00001,ko01000,ko03032 Bacteria 2GJFN@201174,4F15R@85016,COG0164@1,COG0164@2 NA|NA|NA L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids MAG.T1.179_02342 1120950.KB892769_gene5382 1.9e-27 128.6 Propionibacteriales yraN ko:K07460 ko00000 Bacteria 2IQ3X@201174,4DRQN@85009,COG0792@1,COG0792@2 NA|NA|NA L Belongs to the UPF0102 family MAG.T1.179_02343 1043493.BBLU01000010_gene217 1.2e-121 443.7 Actinobacteria ko:K07391 ko00000 Bacteria 2GJIQ@201174,COG0606@1,COG0606@2 NA|NA|NA O PFAM magnesium chelatase ChlI subunit MAG.T1.179_02344 1386089.N865_10205 5.4e-78 298.1 Intrasporangiaceae dprA 5.99.1.2 ko:K03168,ko:K04096 ko00000,ko01000,ko03032,ko03400 Bacteria 2GKDA@201174,4FEJX@85021,COG0758@1,COG0758@2 NA|NA|NA LU Rossmann fold nucleotide-binding protein involved in DNA uptake MAG.T1.179_02345 397278.JOJN01000001_gene2687 3.3e-92 345.1 Propionibacteriales xerC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03733,ko:K04763 ko00000,ko03036 Bacteria 2GNDP@201174,4DN7T@85009,COG4974@1,COG4974@2 NA|NA|NA L Belongs to the 'phage' integrase family. XerC subfamily MAG.T1.179_02346 351607.Acel_1546 3.7e-93 348.2 Frankiales sigD ko:K02405 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 ko00000,ko00001,ko02035,ko03021 Bacteria 2GKBK@201174,4ERYG@85013,COG1191@1,COG1191@2 NA|NA|NA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released MAG.T1.179_02347 570268.ANBB01000022_gene5213 9.7e-31 140.6 Streptosporangiales Bacteria 2IQ64@201174,4EJY5@85012,COG0739@1,COG0739@2 NA|NA|NA M Peptidase family M23 MAG.T1.179_02348 1123322.KB904679_gene3221 3.6e-115 421.4 Actinobacteria rpsB GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02967 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GMYC@201174,COG0052@1,COG0052@2 NA|NA|NA J Belongs to the universal ribosomal protein uS2 family MAG.T1.179_02349 446462.Amir_5910 1e-84 320.1 Pseudonocardiales tsf GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0030312,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02357 ko00000,ko03012,ko03029 Bacteria 2GK4M@201174,4DXP8@85010,COG0264@1,COG0264@2 NA|NA|NA J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome MAG.T1.179_02350 1123320.KB889675_gene4072 2.9e-100 371.7 Actinobacteria pyrH GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006225,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009163,GO:0009165,GO:0009185,GO:0009188,GO:0009193,GO:0009194,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0033862,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042455,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046048,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046872,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 R00158 RC00002 ko00000,ko00001,ko01000 iSB619.SA_RS06240 Bacteria 2GKWQ@201174,COG0528@1,COG0528@2 NA|NA|NA F Catalyzes the reversible phosphorylation of UMP to UDP MAG.T1.179_02351 1123320.KB889675_gene4071 1.4e-69 269.2 Actinobacteria frr GO:0002181,GO:0002184,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0030312,GO:0032984,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02838 ko00000,ko03012 Bacteria 2GJ9J@201174,COG0233@1,COG0233@2 NA|NA|NA J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another MAG.T1.179_02352 65497.JODV01000002_gene4222 1.5e-70 273.1 Pseudonocardiales cdsA GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.41,2.7.7.67 ko:K00981,ko:K07098,ko:K19664 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799,R08966 RC00002 ko00000,ko00001,ko00002,ko01000 iLJ478.TM1397 Bacteria 2I7ZA@201174,4DYTX@85010,COG0575@1,COG0575@2 NA|NA|NA I Belongs to the CDS family MAG.T1.179_02353 266940.Krad_1420 3.5e-147 528.1 Actinobacteria rlmN GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 ko:K06941 ko00000,ko01000,ko03009 Bacteria 2GJ48@201174,COG0820@1,COG0820@2 NA|NA|NA J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs MAG.T1.179_02354 1035308.AQYY01000001_gene1460 0.0 1697.6 Bacteria 4.1.1.38 ko:K20370 ko00620,ko01100,map00620,map01100 R00346 RC02741 ko00000,ko00001,ko01000 Bacteria 28HY3@1,2Z83I@2 NA|NA|NA S phosphoenolpyruvate carboxykinase (diphosphate) activity MAG.T1.179_02355 235985.BBPN01000048_gene8264 8e-78 297.4 Streptacidiphilus tesB GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016042,GO:0016054,GO:0016289,GO:0016787,GO:0016788,GO:0016790,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042802,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046483,GO:0047617,GO:0051186,GO:0055086,GO:0071704,GO:0072329,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901575 ko:K10805 ko01040,map01040 ko00000,ko00001,ko01000,ko01004 iAF1260.b0452,iB21_1397.B21_00408,iBWG_1329.BWG_0334,iEC55989_1330.EC55989_0466,iECBD_1354.ECBD_3203,iECB_1328.ECB_00404,iECDH10B_1368.ECDH10B_0408,iECDH1ME8569_1439.ECDH1ME8569_0437,iECD_1391.ECD_00404,iECH74115_1262.ECH74115_0541,iECIAI1_1343.ECIAI1_0456,iECIAI39_1322.ECIAI39_0221,iECO103_1326.ECO103_0429,iECO111_1330.ECO111_0485,iECO26_1355.ECO26_0487,iECSE_1348.ECSE_0478,iECSP_1301.ECSP_0520,iECUMN_1333.ECUMN_0492,iECW_1372.ECW_m0524,iECs_1301.ECs0506,iEKO11_1354.EKO11_3394,iETEC_1333.ETEC_0505,iEcDH1_1363.EcDH1_3157,iEcE24377_1341.EcE24377A_0488,iEcHS_1320.EcHS_A0529,iEcSMS35_1347.EcSMS35_0496,iEcolC_1368.EcolC_3163,iG2583_1286.G2583_0564,iJO1366.b0452,iSSON_1240.SSON_0440,iUMNK88_1353.UMNK88_505,iWFL_1372.ECW_m0524,iY75_1357.Y75_RS02335,iZ_1308.Z0564,ic_1306.c0571 Bacteria 2GJ1B@201174,2NEH9@228398,COG1946@1,COG1946@2 NA|NA|NA I Acyl-CoA thioesterase MAG.T1.179_02356 1121877.JQKF01000002_gene1657 1.7e-263 916.0 Acidimicrobiia putA 1.2.1.88,1.5.5.2 ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 Bacteria 2GM5R@201174,4CNNB@84992,COG0506@1,COG0506@2,COG1012@1,COG1012@2 NA|NA|NA CE Proline dehydrogenase MAG.T1.179_02357 219305.MCAG_03785 2.7e-162 578.6 Micromonosporales Bacteria 2GJQ9@201174,4DCEF@85008,COG0665@1,COG0665@2 NA|NA|NA E Glycine D-amino acid oxidases (deaminating) MAG.T1.179_02358 367299.JOEE01000004_gene1059 4.1e-44 184.9 Intrasporangiaceae ko:K07005 ko00000 Bacteria 2GJ76@201174,4FGDI@85021,COG3467@1,COG3467@2 NA|NA|NA S Pyridoxamine 5'-phosphate oxidase MAG.T1.179_02359 1032480.MLP_10300 2.6e-135 488.4 Propionibacteriales tpa Bacteria 2GKF6@201174,4DNCH@85009,COG0161@1,COG0161@2 NA|NA|NA H Aminotransferase class-III MAG.T1.179_02360 290397.Adeh_3873 8e-46 189.9 Deltaproteobacteria Bacteria 1MU48@1224,2WISW@28221,42MQ0@68525,COG0841@1,COG0841@2 NA|NA|NA V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family MAG.T1.179_02361 991905.SL003B_2580 6.8e-100 370.2 unclassified Alphaproteobacteria Bacteria 1N7TJ@1224,2TUNQ@28211,4BS55@82117,COG0745@1,COG0745@2 NA|NA|NA K Transcriptional regulatory protein, C terminal MAG.T1.179_02362 991905.SL003B_4027 6.7e-31 139.8 Alphaproteobacteria Bacteria 1N6RP@1224,2UFFA@28211,COG5591@1,COG5591@2 NA|NA|NA S Peptidase propeptide and YPEB domain MAG.T1.179_02363 1317124.DW2_13530 4.2e-11 74.3 Alphaproteobacteria Bacteria 1RGCQ@1224,2A74W@1,2U84B@28211,30W0Q@2 NA|NA|NA MAG.T1.179_02364 314265.R2601_06643 8.7e-65 253.1 Alphaproteobacteria Bacteria 1RJCI@1224,29N8T@1,2U5NK@28211,3096N@2 NA|NA|NA S Tat pathway signal protein MAG.T1.179_02365 1547437.LL06_21885 9.4e-295 1019.2 Phyllobacteriaceae 1.8.1.2 ko:K00380,ko:K02287 ko00196,ko00920,ko01100,ko01120,map00196,map00920,map01100,map01120 M00176 R00858 RC00065 ko00000,ko00001,ko00002,ko00194,ko01000 Bacteria 1MWYV@1224,2TRCH@28211,43NBN@69277,COG0369@1,COG0369@2,COG3182@1,COG3182@2 NA|NA|NA M N-acetylglucosamine transferase MAG.T1.179_02366 314265.R2601_06653 5.2e-117 427.6 Alphaproteobacteria apbE 1.8.1.2,2.7.1.180 ko:K00380,ko:K03734 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R00858 RC00065 ko00000,ko00001,ko00002,ko01000 Bacteria 1MW6K@1224,2TT9G@28211,COG1477@1,COG1477@2 NA|NA|NA H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein MAG.T1.179_02367 388401.RB2150_17569 1.7e-32 146.4 unclassified Rhodobacteraceae XK27_03530 Bacteria 1PJK5@1224,2VB8H@28211,3ZIKH@58840,COG2520@1,COG2520@2 NA|NA|NA H Methyltransferase FkbM domain MAG.T1.179_02368 1131814.JAFO01000001_gene2540 5.5e-24 117.9 Xanthobacteraceae Bacteria 1N5R9@1224,2UEDA@28211,3F1KX@335928,COG3548@1,COG3548@2 NA|NA|NA S Protein of unknown function (DUF1211) MAG.T1.179_02369 1192868.CAIU01000020_gene2783 3e-267 927.5 Phyllobacteriaceae ade GO:0003674,GO:0003824,GO:0006040,GO:0006044,GO:0006046,GO:0008150,GO:0008152,GO:0008448,GO:0009056,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0046348,GO:0071704,GO:1901071,GO:1901072,GO:1901135,GO:1901136,GO:1901575 3.5.4.2 ko:K01486 ko00230,ko01100,map00230,map01100 R01244 RC00477 ko00000,ko00001,ko01000 Bacteria 1MVFP@1224,2TR1X@28211,43H7K@69277,COG1001@1,COG1001@2 NA|NA|NA F Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family MAG.T1.179_02370 1510531.JQJJ01000008_gene3823 1.7e-178 632.5 Bradyrhizobiaceae yodF ko:K03307 ko00000 2.A.21 Bacteria 1MWX6@1224,2TU5R@28211,3JV58@41294,COG0591@1,COG0591@2 NA|NA|NA E Sodium:solute symporter family MAG.T1.179_02371 1320556.AVBP01000011_gene3453 1.4e-15 88.6 Alphaproteobacteria Bacteria 1NNQY@1224,2EFYR@1,2UMMP@28211,339QX@2 NA|NA|NA S Protein of unknown function (DUF3311) MAG.T1.179_02372 981369.JQMJ01000004_gene1265 1.5e-47 197.6 Streptacidiphilus Bacteria 2GN2W@201174,2NGH7@228398,COG0654@1,COG0654@2 NA|NA|NA CH FAD binding domain MAG.T1.179_02373 639283.Snov_2945 6.1e-27 127.1 Xanthobacteraceae rnk ko:K03624,ko:K06140 ko00000,ko03000,ko03021 Bacteria 1MZNY@1224,2UC6B@28211,3F03Z@335928,COG0782@1,COG0782@2 NA|NA|NA K Rnk N-terminus MAG.T1.179_02374 29581.BW37_01535 5.5e-25 120.9 Proteobacteria Bacteria 1P3UJ@1224,2FJJR@1,34B95@2 NA|NA|NA MAG.T1.179_02375 371731.Rsw2DRAFT_1828 6.8e-104 384.0 Rhodobacter Bacteria 1FCQF@1060,1R4PS@1224,2U2PZ@28211,COG1737@1,COG1737@2 NA|NA|NA K Helix-turn-helix domain, rpiR family MAG.T1.179_02376 371731.Rsw2DRAFT_1829 2.1e-216 758.4 Rhodobacter ko:K02035 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 1FCZY@1060,1P1HT@1224,2V8EG@28211,COG0747@1,COG0747@2 NA|NA|NA E Bacterial extracellular solute-binding proteins, family 5 Middle MAG.T1.179_02377 371731.Rsw2DRAFT_1830 2.2e-117 428.7 Alphaproteobacteria dppB ko:K02033,ko:K13890 ko02010,ko02024,map02010,map02024 M00239,M00348 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.11 Bacteria 1MU8Z@1224,2TTTE@28211,COG0601@1,COG0601@2 NA|NA|NA EP PFAM binding-protein-dependent transport systems inner membrane component MAG.T1.179_02378 371731.Rsw2DRAFT_1831 5e-114 417.5 Alphaproteobacteria dppC ko:K02034 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 1MU26@1224,2U4ZC@28211,COG1173@1,COG1173@2 NA|NA|NA EP Binding-protein-dependent transport system inner membrane component MAG.T1.179_02379 371731.Rsw2DRAFT_1832 5.6e-119 434.1 Alphaproteobacteria oppD ko:K02031,ko:K02032 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 1R4KB@1224,2TR0J@28211,COG0444@1,COG0444@2 NA|NA|NA P Belongs to the ABC transporter superfamily MAG.T1.179_02380 371731.Rsw2DRAFT_1833 7.8e-121 440.3 Rhodobacter ko:K02032,ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 1FBNU@1060,1NU4K@1224,2TQTV@28211,COG4608@1,COG4608@2 NA|NA|NA P Belongs to the ABC transporter superfamily MAG.T1.179_02381 1380367.JIBC01000007_gene1032 3.1e-188 664.8 Sulfitobacter Bacteria 1MX4P@1224,2TS1C@28211,3ZYY9@60136,COG5476@1,COG5476@2 NA|NA|NA S MlrC C-terminus MAG.T1.179_02382 1041139.KB902680_gene1627 5.8e-288 996.5 Rhizobiaceae bgaB 3.2.1.23 ko:K12308 ko00052,map00052 R01105 RC00452 ko00000,ko00001,ko01000 Bacteria 1MUVR@1224,2TTC5@28211,4B9ZN@82115,COG1874@1,COG1874@2 NA|NA|NA G Beta-galactosidase MAG.T1.179_02383 311402.Avi_5741 1.8e-76 292.4 Rhizobiaceae ko:K10111 ko02010,map02010 M00194,M00200,M00204,M00207,M00491 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.1 Bacteria 1MU3I@1224,2TQQJ@28211,4BM67@82115,COG3842@1,COG3842@2 NA|NA|NA E Belongs to the ABC transporter superfamily MAG.T1.179_02384 2045.KR76_02335 9.5e-13 81.6 Propionibacteriales Bacteria 2HQ5S@201174,4DS25@85009,COG4585@1,COG4585@2 NA|NA|NA T Histidine kinase-like ATPases MAG.T1.179_02385 1123377.AUIV01000016_gene295 3.6e-56 226.5 Gammaproteobacteria Bacteria 1R7HC@1224,1T5UV@1236,COG2199@1,COG2202@1,COG2202@2,COG3706@2 NA|NA|NA T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) MAG.T1.179_02386 1120949.KB903294_gene4303 3e-192 678.3 Micromonosporales ko:K03321 ko00000,ko02000 2.A.53.3 Bacteria 2GJCB@201174,4D9U7@85008,COG0659@1,COG0659@2 NA|NA|NA P Sulfate permease family MAG.T1.179_02388 543632.JOJL01000050_gene7408 1.4e-31 145.6 Micromonosporales ko:K20276 ko02024,map02024 ko00000,ko00001 Bacteria 2H7QD@201174,4DJZF@85008,COG3170@1,COG3170@2,COG4733@1,COG4733@2 NA|NA|NA NU Fibronectin type III domain MAG.T1.179_02389 710696.Intca_0817 9.9e-107 393.7 Intrasporangiaceae ko:K04088 M00742 ko00000,ko00002,ko01000 Bacteria 2GJ8Q@201174,4FESN@85021,COG0053@1,COG0053@2 NA|NA|NA P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family MAG.T1.179_02390 543632.JOJL01000023_gene1726 3e-30 138.3 Micromonosporales Bacteria 2IJFQ@201174,32SB1@2,4DE0Y@85008,COG1145@1 NA|NA|NA C Ferredoxin MAG.T1.179_02391 1121372.AULK01000001_gene1951 4.8e-98 364.4 Microbacteriaceae uppP 3.6.1.27 ko:K06153 ko00550,map00550 R05627 RC00002 ko00000,ko00001,ko01000,ko01011 Bacteria 2GJVG@201174,4FKPS@85023,COG1968@1,COG1968@2 NA|NA|NA V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin MAG.T1.179_02392 397945.Aave_2022 0.0 1317.4 Comamonadaceae treS GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016310,GO:0034637,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046835,GO:0071704,GO:0071944,GO:1901576 2.4.1.18,2.7.1.175,3.2.1.1,5.4.99.16 ko:K00700,ko:K05343,ko:K16146 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01557,R02108,R02110,R02112,R09945,R11262 RC00002,RC00078,RC01816 ko00000,ko00001,ko00002,ko01000,ko04147 CBM48,GH13 Bacteria 1MVKX@1224,2VHW5@28216,4ABG1@80864,COG0366@1,COG0366@2,COG3281@1,COG3281@2 NA|NA|NA G SMART alpha amylase catalytic sub domain MAG.T1.179_02393 1122622.ATWJ01000008_gene2889 2.3e-207 728.8 Intrasporangiaceae ams 2.4.1.4,3.2.1.1,5.4.99.16 ko:K05341,ko:K05343 ko00500,ko01100,map00500,map01100 R01557,R01823,R02108,R02112,R11262 RC00028,RC01816 ko00000,ko00001,ko01000 GH13 Bacteria 2GKT9@201174,4FEVJ@85021,COG0366@1,COG0366@2 NA|NA|NA G Alpha amylase, catalytic domain MAG.T1.179_02396 1123401.JHYQ01000022_gene1149 1.1e-88 333.2 Gammaproteobacteria XK27_05675 Bacteria 1R6D9@1224,1T0S7@1236,COG0627@1,COG0627@2,COG4947@1,COG4947@2 NA|NA|NA S Putative esterase MAG.T1.179_02397 1299327.I546_5516 1.8e-66 259.2 Mycobacteriaceae 3.8.1.2 ko:K01560 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 R05287 RC00697 ko00000,ko00001,ko01000 Bacteria 23BTU@1762,2IBB1@201174,COG1011@1,COG1011@2 NA|NA|NA S Haloacid dehalogenase-like hydrolase MAG.T1.179_02398 926561.KB900617_gene1274 4.6e-128 464.9 Halanaerobiales scrA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563 2.7.1.211 ko:K02755,ko:K02756,ko:K02757,ko:K02808,ko:K02809,ko:K02810 ko00500,ko02060,map00500,map02060 M00269,M00271 R00811 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.2.1,4.A.1.2.10,4.A.1.2.11,4.A.1.2.12,4.A.1.2.2,4.A.1.2.5,4.A.1.2.6,4.A.1.2.9 iYO844.BSU38050 Bacteria 1TP5X@1239,247WT@186801,3WBUR@53433,COG1263@1,COG1263@2,COG1264@1,COG1264@2 NA|NA|NA G phosphotransferase system, EIIB MAG.T1.179_02399 441769.ABFU01000009_gene2768 2.3e-98 366.3 Bacillus scrB GO:0003674,GO:0003824,GO:0004553,GO:0004564,GO:0005975,GO:0005984,GO:0005985,GO:0005987,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0016052,GO:0016787,GO:0016798,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0046352,GO:0071704,GO:1901575 3.2.1.26 ko:K01193 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00801,R00802,R02410,R03635,R03921,R06088 RC00028,RC00077 ko00000,ko00001,ko01000 GH32 iECSF_1327.ECSF_2568,iYO844.BSU38040 Bacteria 1TPAE@1239,1ZCBA@1386,4H9Y7@91061,COG1621@1,COG1621@2 NA|NA|NA G invertase MAG.T1.179_02401 1304865.JAGF01000001_gene2477 0.0 2343.9 Actinobacteria nifJ 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2I995@201174,COG0674@1,COG0674@2,COG1013@1,COG1013@2,COG1014@1,COG1014@2,COG1144@1,COG1144@2,COG1145@1,COG1145@2 NA|NA|NA C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin MAG.T1.179_02402 1184607.AUCHE_05_04270 0.0 1384.4 Actinobacteria nifJ GO:0003674,GO:0003824,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016491,GO:0016625,GO:0016903,GO:0043873,GO:0050896,GO:0055114 1.18.1.2,1.19.1.1,1.2.7.1,1.2.7.3,1.3.7.1 ko:K00176,ko:K00528,ko:K03737,ko:K20449 ko00010,ko00020,ko00620,ko00650,ko00720,ko00760,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map00760,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00307,M00620 R01196,R01197,R03164,R10159,R10866 RC00004,RC02422,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 iJN678.nifJ,iLF82_1304.LF82_2789,iNRG857_1313.NRG857_06920 Bacteria 2I995@201174,COG0674@1,COG0674@2,COG1013@1,COG1013@2,COG1014@1,COG1014@2,COG1149@1,COG1149@2 NA|NA|NA C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin MAG.T1.179_02403 395965.Msil_2988 1.2e-84 320.1 Beijerinckiaceae 1.3.98.1 ko:K00226 ko00240,ko01100,map00240,map01100 M00051 R01867 RC00051 ko00000,ko00001,ko00002,ko01000 Bacteria 1MXER@1224,2V9AU@28211,3NBTI@45404,COG0167@1,COG0167@2 NA|NA|NA F Dihydroorotate dehydrogenase MAG.T1.179_02404 196162.Noca_2569 1.9e-07 62.4 Propionibacteriales Bacteria 2EGIC@1,2I19N@201174,33AAH@2,4DSK8@85009 NA|NA|NA S Protein of unknown function (DUF3099) MAG.T1.179_02405 935866.JAER01000002_gene1853 7.9e-26 122.5 Propionibacteriales ko:K09165 ko00000 Bacteria 2IQ6Z@201174,4DS6C@85009,COG3360@1,COG3360@2 NA|NA|NA S Dodecin MAG.T1.179_02406 67281.JNZZ01000018_gene544 2.5e-104 386.0 Streptomyces griseus group tldD3 Bacteria 2GZPS@201174,419X8@629295,COG0312@1,COG0312@2 NA|NA|NA S Putative modulator of DNA gyrase MAG.T1.179_02407 645465.ACUR01000099_gene2676 2.3e-167 595.5 Actinobacteria tldD ko:K03568 ko00000,ko01002 Bacteria 2GJ4E@201174,COG0312@1,COG0312@2 NA|NA|NA S Modulator of DNA gyrase MAG.T1.179_02408 1298863.AUEP01000005_gene2400 1.6e-105 390.2 Propionibacteriales murE 6.3.2.13,6.3.2.29,6.3.2.30 ko:K01928,ko:K03802 ko00300,ko00550,map00300,map00550 R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 Bacteria 2GME3@201174,4DPYG@85009,COG0769@1,COG0769@2 NA|NA|NA M Mur ligase middle domain MAG.T1.179_02409 1172188.KB911823_gene478 0.0 1227.2 Intrasporangiaceae cphA 6.3.2.13,6.3.2.29,6.3.2.30 ko:K01928,ko:K03802 ko00300,ko00550,map00300,map00550 R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 Bacteria 2GN0U@201174,4FESF@85021,COG0189@1,COG0189@2,COG0769@1,COG0769@2 NA|NA|NA HJM Belongs to the MurCDEF family MAG.T1.179_02410 479435.Kfla_3707 8.1e-70 270.8 Propionibacteriales cphB GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0042802,GO:0042803,GO:0043170,GO:0044238,GO:0046983,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.15.6 ko:K13282 R09722 RC00064,RC00141 ko00000,ko01000,ko01002 iJN678.slr2001 Bacteria 2I93U@201174,4DP1Z@85009,COG4242@1,COG4242@2 NA|NA|NA PQ Peptidase family S51 MAG.T1.179_02411 43759.JNWK01000070_gene4557 2.7e-35 155.2 Actinobacteria sixA ko:K08296 ko00000,ko01000 Bacteria 2GJ0I@201174,COG2062@1,COG2062@2 NA|NA|NA T phosphohistidine phosphatase, SixA MAG.T1.179_02412 313589.JNB_03230 4.9e-104 384.8 Intrasporangiaceae serB GO:0003674,GO:0003824,GO:0004647,GO:0004721,GO:0004722,GO:0005488,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016597,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0031406,GO:0036094,GO:0036211,GO:0040007,GO:0042578,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564 3.1.3.3 ko:K01079 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R00582 RC00017 ko00000,ko00001,ko00002,ko01000,ko01009 iNJ661.Rv3042c Bacteria 2GJDH@201174,4FFIF@85021,COG0560@1,COG0560@2,COG3830@1,COG3830@2 NA|NA|NA E phosphoserine phosphatase MAG.T1.179_02414 929712.KI912613_gene4331 2.5e-137 495.7 Rubrobacteria yjjK ko:K15738 ko00000,ko02000 3.A.1.120.6 Bacteria 2GJ5M@201174,4CRTW@84995,COG0488@1,COG0488@2 NA|NA|NA S ABC transporter MAG.T1.179_02415 593907.Celgi_0587 6.2e-52 210.7 Cellulomonadaceae pecS Bacteria 2GJ6W@201174,4F19N@85016,COG1846@1,COG1846@2 NA|NA|NA K PFAM regulatory protein MarR MAG.T1.179_02416 1123320.KB889688_gene428 3.9e-57 228.0 Actinobacteria icaR Bacteria 2GMBW@201174,COG1309@1,COG1309@2 NA|NA|NA K transcriptional regulator MAG.T1.179_02418 28042.GU90_04150 1.2e-155 556.6 Pseudonocardiales glmU GO:0000270,GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0005975,GO:0005976,GO:0006022,GO:0006023,GO:0006024,GO:0006629,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009252,GO:0009273,GO:0009987,GO:0016051,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0019134,GO:0022610,GO:0030203,GO:0030260,GO:0033692,GO:0034637,GO:0034645,GO:0035635,GO:0040007,GO:0042546,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044650,GO:0046872,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0070569,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1903509 2.3.1.157,2.7.7.23 ko:K04042,ko:K11528,ko:K16203 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000,ko01002 3.A.1.5.2 iJN678.glmU,iLJ478.TM1629 Bacteria 2GJS1@201174,4DZZ7@85010,COG1207@1,COG1207@2 NA|NA|NA M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain MAG.T1.179_02419 1504319.GM45_3005 2.9e-131 474.9 unclassified Actinobacteria (class) prs GO:0000287,GO:0003674,GO:0003824,GO:0004749,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006015,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0046390,GO:0046391,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901576 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ9S@201174,3UW77@52018,COG0462@1,COG0462@2 NA|NA|NA F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) MAG.T1.179_02420 1227487.C474_12461 8.2e-165 587.4 Halobacteria treZ 2.4.1.18,3.2.1.141 ko:K00700,ko:K01236 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110,R09995,R11256 RC00049 ko00000,ko00001,ko00002,ko01000,ko04147 CBM48,GH13 Archaea 23ZEB@183963,2Y0XG@28890,COG0296@1,arCOG02951@2157 NA|NA|NA G Alpha amylase, catalytic domain MAG.T1.179_02421 446466.Cfla_0883 6.2e-22 110.9 Cellulomonadaceae ctc GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02897 ko03010,map03010 M00178 ko00000,ko00001,ko00002,ko03011 Bacteria 2GJPJ@201174,4F160@85016,COG1825@1,COG1825@2 NA|NA|NA J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance MAG.T1.179_02422 1120950.KB892752_gene6143 6.6e-62 243.8 Propionibacteriales pth GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016787,GO:0016788,GO:0040007,GO:0044464,GO:0052689,GO:0071944,GO:0140098,GO:0140101 3.1.1.29 ko:K01056 ko00000,ko01000,ko03012 Bacteria 2GKCV@201174,4DPFB@85009,COG0193@1,COG0193@2 NA|NA|NA J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis MAG.T1.179_02423 350058.Mvan_3479 6.1e-42 177.9 Mycobacteriaceae cysQ GO:0000103,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008441,GO:0008934,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016020,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019637,GO:0019693,GO:0030145,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042132,GO:0042578,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050308,GO:0050427,GO:0050897,GO:0052745,GO:0052834,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564 3.1.3.7 ko:K01082 ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130 R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03016 Bacteria 232H4@1762,2GMW7@201174,COG1218@1,COG1218@2 NA|NA|NA P Inositol monophosphatase MAG.T1.179_02424 1123393.KB891316_gene1793 4.8e-143 515.4 Betaproteobacteria Bacteria 1MU2C@1224,2VH3V@28216,COG5001@1,COG5001@2 NA|NA|NA T Diguanylate cyclase MAG.T1.179_02425 1907.SGLAU_14165 0.0 1521.9 Actinobacteria mfd ko:K03723 ko03420,map03420 ko00000,ko00001,ko01000,ko03400 Bacteria 2GJ42@201174,COG1197@1,COG1197@2 NA|NA|NA L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site MAG.T1.179_02427 1894.JOER01000013_gene1059 2.9e-59 235.3 Actinobacteria mazG GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0022607,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0035539,GO:0042454,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044464,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0047693,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.6.1.66 ko:K02428 ko00230,map00230 R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 Bacteria 2GNKC@201174,COG1694@1,COG3956@2 NA|NA|NA S PFAM MazG nucleotide pyrophosphohydrolase MAG.T1.179_02428 469371.Tbis_3132 1.8e-176 625.5 Pseudonocardiales eno 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 Bacteria 2GJAY@201174,4DXDR@85010,COG0148@1,COG0148@2 NA|NA|NA G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis MAG.T1.179_02429 1120950.KB892752_gene6171 4.3e-14 84.7 Propionibacteriales divIC ko:K05589,ko:K13052 ko00000,ko03036 Bacteria 2GQH7@201174,4DS5K@85009,COG2919@1,COG2919@2 NA|NA|NA D Septum formation initiator MAG.T1.179_02430 1184609.KILIM_002_00280 1.2e-57 229.6 Dermatophilaceae ppx2 3.6.1.11,3.6.1.40 ko:K01524,ko:K09009 ko00230,map00230 R03409 RC00002 ko00000,ko00001,ko01000 Bacteria 2I8CS@201174,4F6XI@85018,COG1507@1,COG1507@2 NA|NA|NA S Protein of unknown function (DUF501) MAG.T1.179_02431 1906.SFRA_25950 3e-101 375.2 Actinobacteria ppx GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 R03409 RC00002 ko00000,ko00001,ko01000 Bacteria 2GJBN@201174,COG0248@1,COG0248@2 NA|NA|NA FP Ppx GppA phosphatase MAG.T1.179_02433 1504319.GM45_3080 4.5e-38 164.5 Actinobacteria ko:K03567 ko02026,map02026 ko00000,ko00001,ko03000 Bacteria 2IS2K@201174,COG2716@1,COG2716@2 NA|NA|NA E ACT domain MAG.T1.179_02434 935866.JAER01000019_gene3959 1.9e-63 248.8 Propionibacteriales 3.5.1.88 ko:K01462 ko00000,ko01000 Bacteria 2HMJS@201174,4DNQP@85009,COG0242@1,COG0242@2 NA|NA|NA J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions MAG.T1.179_02436 471852.Tcur_4029 1.4e-18 98.6 Streptosporangiales 2.7.1.193 ko:K02803 ko00520,ko02060,map00520,map02060 M00267 R05199 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7 Bacteria 2IQIB@201174,4EKNU@85012,COG1264@1,COG1264@2 NA|NA|NA G phosphotransferase system, EIIB MAG.T1.179_02437 1137269.AZWL01000012_gene2982 1.7e-115 422.9 Actinobacteria nagE 2.7.1.193,2.7.1.199 ko:K02803,ko:K02804,ko:K20116,ko:K20117,ko:K20118 ko00010,ko00520,ko02060,map00010,map00520,map02060 M00267,M00809 R02738,R05199 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.13,4.A.1.1.14,4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7,4.A.1.1.9 Bacteria 2GKPM@201174,COG1263@1,COG1263@2 NA|NA|NA G Phosphotransferase System MAG.T1.179_02438 1120950.KB892720_gene1909 1.8e-100 372.9 Propionibacteriales nagA 3.5.1.25 ko:K01443 ko00520,ko01130,map00520,map01130 R02059 RC00166,RC00300 ko00000,ko00001,ko01000 iNJ661.Rv3332 Bacteria 2GK1E@201174,4DPBF@85009,COG1820@1,COG1820@2 NA|NA|NA G Belongs to the metallo-dependent hydrolases superfamily. NagA family MAG.T1.179_02439 1254432.SCE1572_32985 2.5e-21 110.2 Proteobacteria Bacteria 1N5ID@1224,COG3591@1,COG3591@2 NA|NA|NA E Belongs to the peptidase S1B family MAG.T1.179_02440 67373.JOBF01000006_gene2459 2.4e-36 159.1 Actinobacteria Bacteria 2GP92@201174,COG1309@1,COG1309@2 NA|NA|NA K transcriptional regulator MAG.T1.179_02441 65497.JODV01000007_gene534 7.5e-129 466.8 Pseudonocardiales menB GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0008150,GO:0008152,GO:0008935,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0042180,GO:0042181,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:0071890,GO:1901576,GO:1901661,GO:1901663 4.1.3.36 ko:K01661 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R07263 RC01923 ko00000,ko00001,ko00002,ko01000 iJN678.menB,iYL1228.KPN_02660 Bacteria 2GK5G@201174,4E09A@85010,COG0447@1,COG0447@2 NA|NA|NA H Belongs to the enoyl-CoA hydratase isomerase family. MenB subfamily MAG.T1.179_02442 478801.Ksed_24140 1.6e-72 280.0 Dermacoccaceae menC GO:0008150,GO:0040007 4.2.1.113,5.1.1.20,5.1.1.3 ko:K01776,ko:K02549,ko:K19802 ko00130,ko00471,ko01100,ko01110,map00130,map00471,map01100,map01110 M00116 R00260,R04031,R10938 RC00302,RC01053,RC03309 ko00000,ko00001,ko00002,ko01000,ko01011 iNJ661.Rv0553,iSB619.SA_RS09080 Bacteria 1ZVR3@145357,2GJJR@201174,COG4948@1,COG4948@2 NA|NA|NA H Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) MAG.T1.179_02443 477641.MODMU_4977 3.2e-107 396.0 Frankiales menD GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 2.2.1.9 ko:K02551 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R08165 RC02186 ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS05085 Bacteria 2GMEB@201174,4ES4N@85013,COG1165@1,COG1165@2 NA|NA|NA H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) MAG.T1.179_02444 1356852.N008_18865 2.9e-14 84.7 Cytophagia Bacteria 47RW1@768503,4NUPH@976,COG0607@1,COG0607@2 NA|NA|NA P Rhodanese Homology Domain MAG.T1.179_02445 479435.Kfla_6301 1.6e-113 416.4 Propionibacteriales menF 2.6.1.85,4.1.3.27,5.4.4.2 ko:K01657,ko:K02552,ko:K13950 ko00130,ko00400,ko00405,ko00790,ko01053,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00130,map00400,map00405,map00790,map01053,map01100,map01110,map01130,map01230,map02024,map02025 M00023,M00116 R00985,R00986,R01716,R01717 RC00010,RC00588,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKE8@201174,4DPGF@85009,COG1169@1,COG1169@2 NA|NA|NA HQ Isochorismate synthase MAG.T1.179_02446 1137269.AZWL01000015_gene734 2.8e-94 351.7 Actinobacteria ubiE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008425,GO:0008757,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016741,GO:0030580,GO:0032259,GO:0042180,GO:0042181,GO:0043333,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 iAF1260.b3833,iBWG_1329.BWG_3511,iE2348C_1286.E2348C_4147,iEC042_1314.EC042_4213,iEC55989_1330.EC55989_4310,iECDH10B_1368.ECDH10B_4024,iECDH1ME8569_1439.ECDH1ME8569_3712,iECH74115_1262.ECH74115_5274,iECIAI1_1343.ECIAI1_4028,iECIAI39_1322.ECIAI39_3162,iECO103_1326.ECO103_4330,iECO111_1330.ECO111_4661,iECO26_1355.ECO26_4752,iECSE_1348.ECSE_4121,iECSP_1301.ECSP_4888,iECUMN_1333.ECUMN_4359,iECW_1372.ECW_m4135,iECs_1301.ECs4763,iEKO11_1354.EKO11_4524,iETEC_1333.ETEC_4110,iEcDH1_1363.EcDH1_4146,iEcE24377_1341.EcE24377A_4354,iEcHS_1320.EcHS_A4057,iEcSMS35_1347.EcSMS35_4216,iEcolC_1368.EcolC_4175,iG2583_1286.G2583_4633,iJO1366.b3833,iJR904.b3833,iSBO_1134.SBO_3847,iSDY_1059.SDY_3910,iSFV_1184.SFV_3665,iSF_1195.SF3911,iSFxv_1172.SFxv_4263,iSSON_1240.SSON_4008,iS_1188.S3843,iSbBS512_1146.SbBS512_E4305,iUMNK88_1353.UMNK88_4663,iWFL_1372.ECW_m4135,iY75_1357.Y75_RS17910,iZ_1308.Z5355 Bacteria 2GKFZ@201174,COG0500@1,COG2226@2 NA|NA|NA H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) MAG.T1.179_02447 452652.KSE_34280 2.3e-13 82.8 Kitasatospora Bacteria 2HRC6@201174,2M45I@2063,COG1280@1,COG1280@2 NA|NA|NA E Sap, sulfolipid-1-addressing protein MAG.T1.179_02448 1463887.KL589953_gene93 2.6e-66 258.8 Actinobacteria pflA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0018307,GO:0019538,GO:0033554,GO:0036211,GO:0043170,GO:0043364,GO:0043365,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0055114,GO:0070283,GO:0071704,GO:1901564 1.97.1.4 ko:K04069 R04710 ko00000,ko01000 iECOK1_1307.ECOK1_0925,iEcE24377_1341.EcE24377A_0980,iEcSMS35_1347.EcSMS35_2219,iYL1228.KPN_00930 Bacteria 2GN2B@201174,COG1180@1,COG1180@2 NA|NA|NA C Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine MAG.T1.179_02449 479431.Namu_3208 0.0 1110.5 Actinobacteria pflB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006566,GO:0006567,GO:0006629,GO:0006631,GO:0006807,GO:0008150,GO:0008152,GO:0008861,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009987,GO:0016020,GO:0016054,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0016999,GO:0017144,GO:0019541,GO:0019752,GO:0032787,GO:0042737,GO:0043436,GO:0043875,GO:0044237,GO:0044238,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046459,GO:0070689,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.3.1.54 ko:K00656 ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120 R00212,R06987 RC00004,RC01181,RC02742,RC02833 ko00000,ko00001,ko01000 iECH74115_1262.ECH74115_1064,iECIAI39_1322.ECIAI39_2245,iECSP_1301.ECSP_1007,iECs_1301.ECs0986,iEcSMS35_1347.EcSMS35_2218,iEcSMS35_1347.EcSMS35_3410,iG2583_1286.G2583_1138,iSDY_1059.SDY_2358,iZ_1308.Z1248 Bacteria 2GTTT@201174,COG1882@1,COG1882@2 NA|NA|NA C formate acetyltransferase MAG.T1.179_02450 1120950.KB892779_gene972 3.3e-138 498.4 Propionibacteriales 1.3.99.38 ko:K21401 ko00000,ko01000 Bacteria 2GKGH@201174,4DPE1@85009,COG0644@1,COG0644@2 NA|NA|NA C FAD binding domain MAG.T1.179_02451 436229.JOEH01000024_gene946 1.3e-50 205.7 Streptacidiphilus nuoA GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044464,GO:0050136,GO:0055114,GO:0071944,GO:0098796,GO:1902494 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2IKWT@201174,2NJ30@228398,COG0838@1,COG0838@2 NA|NA|NA C NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 MAG.T1.179_02452 1504319.GM45_4125 2.3e-85 321.6 unclassified Actinobacteria (class) nuoB 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2GJXR@201174,3UWJQ@52018,COG0377@1,COG0377@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient MAG.T1.179_02453 1003195.SCAT_3486 1.1e-90 339.7 Actinobacteria nuoC GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0050136,GO:0055114 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2GIRH@201174,COG0852@1,COG0852@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient MAG.T1.179_02454 1504319.GM45_4135 2e-194 685.3 unclassified Actinobacteria (class) nuoD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2GKEZ@201174,3UWKD@52018,COG0649@1,COG0649@2 NA|NA|NA C Belongs to the complex I 49 kDa subunit family MAG.T1.179_02455 1504319.GM45_4140 1.6e-64 252.7 unclassified Actinobacteria (class) nuoE GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3,1.6.99.3 ko:K00334,ko:K00335,ko:K03943 ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016 M00143,M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1,3.D.1.6 Bacteria 2GKG0@201174,3UWSV@52018,COG1905@1,COG1905@2 NA|NA|NA C Thioredoxin-like [2Fe-2S] ferredoxin MAG.T1.179_02459 1137268.AZXF01000005_gene3182 7.8e-102 377.5 Streptosporangiales Bacteria 2GJHA@201174,4EIW6@85012,COG0464@1,COG0464@2 NA|NA|NA O Protein of unknown function (DUF3631) MAG.T1.179_02460 298655.KI912266_gene787 1.2e-142 513.1 Frankiales Bacteria 2GNQB@201174,4ETFP@85013,COG3547@1,COG3547@2 NA|NA|NA L transposase IS116 IS110 IS902 family protein MAG.T1.179_02461 446466.Cfla_3211 3.6e-53 214.9 Actinobacteria Bacteria 2CJUD@1,2IS5A@201174,2ZW9H@2 NA|NA|NA MAG.T1.179_02462 397278.JOJN01000010_gene2233 4.8e-08 65.5 Propionibacteriales Bacteria 2BXNT@1,2IIU0@201174,30VN0@2,4DQTR@85009 NA|NA|NA S Septum formation MAG.T1.179_02463 196162.Noca_0411 9.2e-14 84.0 Propionibacteriales Bacteria 2GMVK@201174,4DTD1@85009,COG4243@1,COG4243@2 NA|NA|NA S VKc MAG.T1.179_02464 397278.JOJN01000018_gene3503 2.3e-291 1008.1 Propionibacteriales 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 Bacteria 2GIRF@201174,4DN8M@85009,COG2217@1,COG2217@2 NA|NA|NA P Heavy-metal-associated domain MAG.T1.179_02465 1033730.CAHG01000006_gene1155 4.9e-18 96.7 Propionibacteriales ko:K07213 ko04978,map04978 ko00000,ko00001 Bacteria 2GQK5@201174,4DSND@85009,COG2608@1,COG2608@2 NA|NA|NA P Heavy-metal-associated domain MAG.T1.179_02467 153948.NAL212_0227 1.1e-30 139.8 Nitrosomonadales Bacteria 1PE85@1224,2W92M@28216,373FB@32003,COG0500@1,COG2226@2 NA|NA|NA Q Mycolic acid cyclopropane synthetase MAG.T1.179_02468 1211815.CBYP010000062_gene3157 0.0 1112.8 Frankiales 3.6.3.4 ko:K01533 R00086 RC00002 ko00000,ko01000 3.A.3.5 Bacteria 2GIRF@201174,4ERFZ@85013,COG2217@1,COG2217@2 NA|NA|NA P E1-E2 ATPase MAG.T1.179_02469 1122998.AUHZ01000010_gene1513 1.2e-10 72.4 Propionibacteriales csoR GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010038,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0042221,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0046688,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 ko:K21600 ko00000,ko03000 Bacteria 2IQAC@201174,4DRND@85009,COG1937@1,COG1937@2 NA|NA|NA S Metal-sensitive transcriptional repressor MAG.T1.179_02471 196162.Noca_3785 6.6e-55 220.7 Propionibacteriales 1.11.1.15 ko:K03386,ko:K03564,ko:K16922 ko04214,map04214 ko00000,ko00001,ko01000,ko01002,ko04147 Bacteria 2IGFI@201174,4DRG7@85009,COG1225@1,COG1225@2 NA|NA|NA O Redoxin MAG.T1.179_02472 1122609.AUGT01000027_gene2723 2.2e-113 415.6 Propionibacteriales Bacteria 2GMXW@201174,4DTAU@85009,COG0785@1,COG0785@2 NA|NA|NA O Cytochrome C biogenesis protein transmembrane region MAG.T1.179_02473 446466.Cfla_0354 3.4e-17 94.4 Bacteria Bacteria COG0695@1,COG0695@2 NA|NA|NA O Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins MAG.T1.179_02474 1035308.AQYY01000001_gene2021 9.8e-75 287.3 Peptococcaceae Bacteria 1TQ1H@1239,247VG@186801,264FP@186807,COG5002@1,COG5002@2 NA|NA|NA T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MAG.T1.179_02475 1240349.ANGC01000011_gene329 4.8e-78 297.7 Nocardiaceae Bacteria 2GK5S@201174,4G8SS@85025,COG0745@1,COG0745@2 NA|NA|NA K Transcriptional regulatory protein, C terminal MAG.T1.179_02477 223184.AS25_05575 2.5e-142 512.3 Micrococcaceae Bacteria 1W8P3@1268,2GMJ4@201174,COG2132@1,COG2132@2 NA|NA|NA Q Multicopper oxidase MAG.T1.179_02478 313589.JNB_01175 1.4e-33 149.8 Intrasporangiaceae Bacteria 2IKUE@201174,4FGXY@85021,COG3544@1,COG3544@2 NA|NA|NA S Domain of unknown function (DUF4142) MAG.T1.179_02479 1122138.AQUZ01000019_gene8156 3.5e-38 165.6 Propionibacteriales Bacteria 2GN53@201174,4DRB6@85009,COG4447@1,COG4447@2 NA|NA|NA S cellulose binding MAG.T1.179_02480 40571.JOEA01000029_gene5793 2e-22 113.6 Bacteria Bacteria 2E7BJ@1,331UW@2 NA|NA|NA MAG.T1.179_02481 1397278.AYMV01000001_gene448 2.2e-42 179.1 Actinobacteria yycO Bacteria 2INZ0@201174,COG3863@1,COG3863@2 NA|NA|NA S Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family MAG.T1.179_02483 1385519.N801_04205 2.1e-131 475.7 Intrasporangiaceae Bacteria 2GS79@201174,4FFP0@85021,COG3547@1,COG3547@2 NA|NA|NA L Transposase MAG.T1.179_02484 1101188.KI912157_gene87 1.6e-21 109.8 Actinobacteria Bacteria 2EKKY@1,2I2JI@201174,33EAR@2 NA|NA|NA MAG.T1.179_02486 1035308.AQYY01000002_gene68 6.8e-29 135.2 Bacteria Bacteria COG1652@1,COG1652@2,COG3170@1,COG3170@2 NA|NA|NA S positive regulation of growth rate MAG.T1.179_02487 134676.ACPL_5887 3.5e-15 88.2 Micromonosporales Bacteria 2E4ST@1,2GSCH@201174,32ZM5@2,4DEKN@85008 NA|NA|NA S Putative Flp pilus-assembly TadE/G-like MAG.T1.179_02488 196162.Noca_2227 4.5e-15 87.8 Propionibacteriales Bacteria 2GRCJ@201174,4DSH3@85009,COG4961@1,COG4961@2 NA|NA|NA U overlaps another CDS with the same product name MAG.T1.179_02489 110319.CF8_1721 3.6e-41 175.6 Propionibacteriales Bacteria 2DVVA@1,2IHH0@201174,32V07@2,4DRC3@85009 NA|NA|NA MAG.T1.179_02491 526225.Gobs_0675 9e-21 106.7 Actinobacteria Bacteria 2I36X@201174,COG4961@1,COG4961@2 NA|NA|NA U overlaps another CDS with the same product name MAG.T1.179_02493 397278.JOJN01000013_gene2572 3e-50 205.7 Propionibacteriales ko:K12511 ko00000,ko02044 Bacteria 2HZTC@201174,4DRIG@85009,COG2064@1,COG2064@2 NA|NA|NA NU type II secretion system protein MAG.T1.179_02494 1385519.N801_09660 2.3e-52 212.6 Intrasporangiaceae Bacteria 2GN6E@201174,4FHCH@85021,COG4965@1,COG4965@2 NA|NA|NA U Type II secretion system (T2SS), protein F MAG.T1.179_02495 110319.CF8_2349 3.2e-110 405.6 Propionibacteriales ko:K02283 ko00000,ko02035,ko02044 Bacteria 2GKKJ@201174,4DWY1@85009,COG4962@1,COG4962@2 NA|NA|NA U PFAM type II secretion system protein E MAG.T1.179_02496 110319.CF8_2348 2.7e-39 169.1 Propionibacteriales Bacteria 2I57A@201174,4DWY4@85009,COG1192@1,COG1192@2 NA|NA|NA D Involved in chromosome partitioning MAG.T1.179_02497 196162.Noca_2220 8.4e-29 134.0 Propionibacteriales Bacteria 2HIQE@201174,4DWST@85009,COG1261@1,COG1261@2 NA|NA|NA NO SAF MAG.T1.179_02499 591158.SSMG_08390 2e-08 66.2 Actinobacteria Bacteria 2E3KC@1,2GQQS@201174,32YIM@2 NA|NA|NA S Domain of unknown function (DUF4913) MAG.T1.179_02500 1464048.JNZS01000015_gene3724 3.4e-117 429.1 Micromonosporales Bacteria 2GNQ7@201174,4D94E@85008,COG3505@1,COG3505@2 NA|NA|NA U Type IV secretory pathway, VirD4 components MAG.T1.179_02501 1449353.JQMQ01000005_gene5752 6.4e-122 444.5 Actinobacteria Bacteria 2I37H@201174,COG3451@1,COG3451@2 NA|NA|NA U type IV secretory pathway VirB4 MAG.T1.179_02502 935839.JAGJ01000019_gene2251 1.6e-68 266.9 Promicromonosporaceae Bacteria 2B737@1,2HZC7@201174,32044@2,4F5Y2@85017 NA|NA|NA MAG.T1.179_02503 1121928.AUHE01000033_gene430 1e-199 702.6 Gordoniaceae insI1 GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004803,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0030983,GO:0032135,GO:0032196,GO:0032991,GO:0032993,GO:0034641,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 ko:K07482 ko00000 Bacteria 2GMZX@201174,4GASI@85026,COG2826@1,COG2826@2 NA|NA|NA L Transposase and inactivated derivatives IS30 family MAG.T1.179_02504 110319.CF8_4229 2.8e-132 478.4 Actinobacteria ko:K07497 ko00000 Bacteria 2GKDY@201174,COG2801@1,COG2801@2 NA|NA|NA L PFAM Integrase catalytic MAG.T1.179_02505 526226.Gbro_2585 5.7e-138 497.3 Gordoniaceae Bacteria 2I9ZX@201174,4GFWP@85026,COG4974@1,COG4974@2 NA|NA|NA L integrase domain protein SAM domain protein MAG.T1.179_02506 526226.Gbro_2584 1.2e-234 819.3 Gordoniaceae ko:K03733,ko:K04763 ko00000,ko03036 Bacteria 2IBD6@201174,4GFSJ@85026,COG4974@1,COG4974@2 NA|NA|NA L PFAM integrase family protein MAG.T1.179_02507 253839.SSNG_07182 3.8e-15 87.8 Actinobacteria Bacteria 2H714@201174,COG1484@1,COG1484@2 NA|NA|NA L PFAM IstB domain protein ATP-binding protein MAG.T1.179_02508 33876.JNXY01000001_gene6365 5.5e-117 427.6 Micromonosporales ko:K07497 ko00000 Bacteria 2GNRT@201174,4DHN8@85008,COG2801@1,COG2801@2 NA|NA|NA L Integrase core domain MAG.T1.179_02509 1193181.BN10_160001 1.7e-195 688.7 Intrasporangiaceae ko:K07493 ko00000 Bacteria 2GM8F@201174,4FJAV@85021,COG3328@1,COG3328@2 NA|NA|NA L Transposase, Mutator family MAG.T1.179_02510 710696.Intca_0789 5.4e-21 106.7 Intrasporangiaceae Bacteria 2GS79@201174,4FFP0@85021,COG3547@1,COG3547@2 NA|NA|NA L Transposase MAG.T1.179_02511 1380354.JIAN01000005_gene2339 5.6e-53 214.9 Actinobacteria ko:K02529 ko00000,ko03000 Bacteria 2GQER@201174,COG1609@1,COG1609@2 NA|NA|NA K PFAM regulatory protein LacI MAG.T1.179_02512 1120933.ATUY01000009_gene1413 3.1e-208 731.5 Actinobacteria malL 3.2.1.10 ko:K01182 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00801,R01718,R01791,R06199 RC00028,RC00059,RC00077,RC00451 ko00000,ko00001,ko01000 GH13 Bacteria 2GKS4@201174,4D32X@85005,COG0366@1,COG0366@2 NA|NA|NA G Alpha amylase, catalytic domain protein MAG.T1.179_02513 644283.Micau_3475 1.9e-27 129.4 Micromonosporales ppaX 3.1.3.18,3.6.1.1 ko:K01091,ko:K06019,ko:K16017 ko00190,ko00630,ko01051,ko01100,ko01110,ko01130,map00190,map00630,map01051,map01100,map01110,map01130 R01334,R06587 RC00017,RC00078 ko00000,ko00001,ko01000 Bacteria 2I9FC@201174,4DFT5@85008,COG0546@1,COG0546@2 NA|NA|NA S HAD-superfamily hydrolase, subfamily IA, variant 3 MAG.T1.179_02514 1043205.AFYF01000045_gene2925 1.6e-08 66.6 Intrasporangiaceae Bacteria 2ET1V@1,2GZYR@201174,33KK0@2,4FI7B@85021 NA|NA|NA S Protein of unknown function (DUF2975) MAG.T1.179_02515 35754.JNYJ01000011_gene741 2.1e-22 111.3 Micromonosporales yozG ko:K07727 ko00000,ko03000 Bacteria 2GQZM@201174,4DEY7@85008,COG3655@1,COG3655@2 NA|NA|NA K Cro/C1-type HTH DNA-binding domain MAG.T1.179_02516 35754.JNYJ01000086_gene2338 9.7e-22 109.4 Micromonosporales Bacteria 2EH37@1,2GQTI@201174,33AV6@2,4DFMM@85008 NA|NA|NA MAG.T1.179_02519 471853.Bcav_3589 1.4e-38 166.8 Bacteria MA20_05910 ko:K03668,ko:K09914 ko00000 Bacteria COG3187@1,COG3187@2 NA|NA|NA O response to heat MAG.T1.179_02520 290340.AAur_1158 9.7e-29 134.4 Actinobacteria ko:K03088 ko00000,ko03021 Bacteria 2IKVM@201174,COG1595@1,COG1595@2 NA|NA|NA K belongs to the sigma-70 factor family, ECF subfamily MAG.T1.179_02521 1184609.KILIM_042_00240 8.8e-22 110.5 Actinobacteria ko:K03088 ko00000,ko03021 Bacteria 2IRNG@201174,COG1595@1,COG1595@2 NA|NA|NA K belongs to the sigma-70 factor family, ECF subfamily MAG.T1.179_02522 526225.Gobs_1409 2.5e-45 189.1 Actinobacteria apt 2.4.2.7 ko:K00759 ko00230,ko01100,map00230,map01100 R00190,R01229,R04378 RC00063 ko00000,ko00001,ko01000,ko04147 Bacteria 2IHB6@201174,COG0503@1,COG0503@2 NA|NA|NA F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis MAG.T1.179_02523 471856.Jden_0753 3.4e-10 71.2 Actinobacteria Bacteria 2C7TF@1,2H7C8@201174,34723@2 NA|NA|NA MAG.T1.179_02524 1236902.ANAS01000011_gene1431 1.7e-38 167.9 Streptosporangiales Bacteria 2I182@201174,4EMEY@85012,COG0577@1,COG0577@2 NA|NA|NA V efflux transmembrane transporter activity MAG.T1.179_02525 1121365.AQXB01000002_gene1313 1.1e-44 186.8 Corynebacteriaceae ko:K02003,ko:K09810 ko02010,map02010 M00255,M00258 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.125 Bacteria 22JNT@1653,2GM25@201174,COG1136@1,COG1136@2 NA|NA|NA V ABC transporter, ATP-binding protein MAG.T1.179_02526 446466.Cfla_1156 3.4e-30 137.9 Actinobacteria ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GN8P@201174,COG1131@1,COG1131@2 NA|NA|NA V ABC transporter MAG.T1.179_02527 1206101.AZXC01000010_gene23 5.1e-83 314.7 Actinobacteria Bacteria 2GIS3@201174,COG0604@1,COG0604@2 NA|NA|NA C alcohol dehydrogenase MAG.T1.179_02528 1108045.GORHZ_150_00010 3e-50 205.3 Actinobacteria Bacteria 2IMPX@201174,2ZF5I@2,arCOG07533@1 NA|NA|NA S Domain of unknown function (DUF4386) MAG.T1.179_02530 1385519.N801_00635 1.2e-82 313.5 Intrasporangiaceae Bacteria 2GIS3@201174,4FGCG@85021,COG0604@1,COG0604@2 NA|NA|NA C Zinc-binding dehydrogenase MAG.T1.179_02531 1146883.BLASA_1810 1.1e-56 227.3 Actinobacteria ko:K18831,ko:K21498 ko00000,ko02048,ko03000 Bacteria 2GNHW@201174,COG3093@1,COG3093@2 NA|NA|NA K antidote protein MAG.T1.179_02532 713605.ADHG01000001_gene13 9.4e-23 114.0 Lactobacillaceae Bacteria 1V1N6@1239,2C08P@1,2ZC0W@2,3FA9V@33958,4IHU9@91061 NA|NA|NA S Domain of unknown function (DUF4417) MAG.T1.179_02535 1077972.ARGLB_029_00020 4.8e-11 75.1 Bacteria Bacteria 2ECD9@1,31QH2@2 NA|NA|NA MAG.T1.179_02536 935866.JAER01000004_gene3859 1.6e-37 161.8 Propionibacteriales Bacteria 2E5NA@1,2IQ91@201174,330D3@2,4DRUP@85009 NA|NA|NA S Domain of unknown function (DUF4287) MAG.T1.179_02537 765911.Thivi_2384 4.9e-23 115.2 Chromatiales MA20_05910 ko:K03668,ko:K09914 ko00000 Bacteria 1NGG1@1224,1S7JT@1236,1WYQQ@135613,COG3187@1,COG3187@2 NA|NA|NA O META domain MAG.T1.179_02538 67267.JNXT01000003_gene4090 1.8e-09 68.6 Actinobacteria Bacteria 2B1UQ@1,2GTR9@201174,31UAQ@2 NA|NA|NA MAG.T1.179_02539 1280390.CBQR020000100_gene2320 3.2e-90 338.6 Paenibacillaceae Bacteria 1TSWF@1239,274FR@186822,4HANV@91061,COG0604@1,COG0604@2 NA|NA|NA C Zinc-binding dehydrogenase MAG.T1.179_02540 543632.JOJL01000004_gene4174 3.7e-34 152.1 Micromonosporales Bacteria 2EJNG@1,2H04Y@201174,33DDC@2,4DM96@85008 NA|NA|NA S Domain of unknown function (DUF4386) MAG.T1.179_02541 1172188.KB911822_gene695 2.9e-15 87.8 Intrasporangiaceae Bacteria 2DNVA@1,2GRAT@201174,32ZBE@2,4FJSY@85021 NA|NA|NA MAG.T1.179_02542 42256.RradSPS_0358 1.7e-205 723.0 Rubrobacteria ko:K03556 ko00000,ko03000 Bacteria 2HENR@201174,4CPC9@84995,COG2909@1,COG2909@2 NA|NA|NA K helix_turn_helix, Lux Regulon MAG.T1.179_02543 469371.Tbis_3586 1.8e-16 92.4 Actinobacteria Bacteria 2B9QR@1,2H7N9@201174,3233A@2 NA|NA|NA MAG.T1.179_02544 211114.JOEF01000049_gene5388 2e-10 72.4 Pseudonocardiales Bacteria 2B67R@1,2HS99@201174,31Z4Y@2,4ECXR@85010 NA|NA|NA MAG.T1.179_02545 1306174.JODP01000006_gene3417 8.9e-45 186.0 Actinobacteria folE GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006082,GO:0006139,GO:0006575,GO:0006725,GO:0006729,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008616,GO:0009058,GO:0009108,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0019752,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042455,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901657,GO:1901659 2.7.6.3,3.5.4.16 ko:K00950,ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R03503,R04639,R05046,R05048 RC00002,RC00017,RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 iIT341.HP0928 Bacteria 2GP2P@201174,COG0302@1,COG0302@2 NA|NA|NA H GTP cyclohydrolase MAG.T1.179_02546 590998.Celf_0561 4.2e-89 334.7 Cellulomonadaceae folP 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJDQ@201174,4F0TG@85016,COG0294@1,COG0294@2 NA|NA|NA H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives MAG.T1.179_02547 235985.BBPN01000010_gene4524 3.1e-34 151.4 Streptacidiphilus folB GO:0008150,GO:0040007 1.13.11.81,2.7.6.3,4.1.2.25,5.1.99.8 ko:K01633,ko:K13940 ko00790,ko01100,map00790,map01100 M00126,M00840 R03503,R03504,R11037,R11073 RC00002,RC00017,RC00721,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 Bacteria 2IHSW@201174,2NIR6@228398,COG1539@1,COG1539@2 NA|NA|NA H Dihydroneopterin aldolase MAG.T1.179_02548 1348663.KCH_43430 7e-36 157.1 Kitasatospora folK 2.7.6.3,4.1.2.25 ko:K00950,ko:K13940 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503,R03504 RC00002,RC00017,RC00721,RC00943 ko00000,ko00001,ko00002,ko01000 Bacteria 2H3G6@201174,2M2ED@2063,COG0801@1,COG0801@2 NA|NA|NA H 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) MAG.T1.179_02549 1246995.AFR_41455 3.7e-13 81.6 Micromonosporales Bacteria 2DRQG@1,2IFEG@201174,33CMQ@2,4DEJ0@85008 NA|NA|NA S Protein of unknown function (DUF3180) MAG.T1.179_02550 1121926.AXWO01000013_gene2110 6.9e-07 60.1 Glycomycetales Bacteria 2E8UC@1,2GRUC@201174,3334W@2,4EYXG@85014 NA|NA|NA MAG.T1.179_02551 436229.JOEH01000009_gene4683 9.4e-81 307.4 Streptacidiphilus nuoD GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 ko:K00333,ko:K05579,ko:K13378 ko00190,ko01100,map00190,map01100 M00144,M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2GKEZ@201174,2NEX2@228398,COG0649@1,COG0649@2 NA|NA|NA C Respiratory-chain NADH dehydrogenase, 49 Kd subunit MAG.T1.179_02552 1120950.KB892801_gene1727 1.2e-35 156.4 Propionibacteriales ko:K09167 ko00000 Bacteria 2IR88@201174,4DRVV@85009,COG3402@1,COG3402@2 NA|NA|NA S Bacterial PH domain MAG.T1.179_02553 1123320.KB889585_gene1795 3.6e-87 328.9 Actinobacteria ko:K08981 ko00000 Bacteria 2GJCD@201174,COG3428@1,COG3428@2 NA|NA|NA S PFAM membrane-flanked domain MAG.T1.179_02555 1123320.KB889585_gene1805 6.6e-98 364.0 Actinobacteria Bacteria 2I2F6@201174,COG5495@1,COG5495@2 NA|NA|NA S Oxidoreductase MAG.T1.179_02556 263358.VAB18032_02725 1.1e-79 303.5 Micromonosporales panC GO:0000166,GO:0000287,GO:0001505,GO:0003674,GO:0003824,GO:0004592,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0019482,GO:0019752,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033317,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042133,GO:0042364,GO:0042398,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0065007,GO:0065008,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv3602c Bacteria 2GJEQ@201174,4D99B@85008,COG0414@1,COG0414@2 NA|NA|NA H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate MAG.T1.179_02557 1348663.KCH_34820 2.4e-181 642.1 Kitasatospora nadB 1.3.5.4,1.4.3.16,2.4.2.19 ko:K00244,ko:K00278,ko:K00767 ko00020,ko00190,ko00250,ko00620,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00250,map00620,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00115,M00150,M00173 R00357,R00481,R02164,R03348 RC00006,RC00045,RC02566,RC02877 ko00000,ko00001,ko00002,ko01000 Bacteria 2I2IJ@201174,2M0NV@2063,COG0029@1,COG0029@2 NA|NA|NA H Fumarate reductase flavoprotein C-term MAG.T1.179_02558 1463845.JOIG01000008_gene3720 2.7e-99 368.6 Actinobacteria nadC 1.4.3.16,2.4.2.19 ko:K00278,ko:K00767 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481,R03348 RC00006,RC02566,RC02877 ko00000,ko00001,ko00002,ko01000 Bacteria 2I2IP@201174,COG0157@1,COG0157@2 NA|NA|NA H Belongs to the NadC ModD family MAG.T1.179_02559 35754.JNYJ01000036_gene3729 6.3e-97 360.5 Micromonosporales coaX GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1986 Bacteria 2GMRQ@201174,4D9W0@85008,COG1521@1,COG1521@2 NA|NA|NA H Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis MAG.T1.179_02560 1380390.JIAT01000011_gene2320 1.8e-124 453.0 Rubrobacteria Bacteria 2GKEK@201174,4CR6A@84995,COG4320@1,COG4320@2 NA|NA|NA S Uncharacterized protein conserved in bacteria (DUF2252) MAG.T1.179_02561 1380356.JNIK01000002_gene4723 1.6e-08 66.6 Actinobacteria Bacteria 2EPZ4@1,2GYV7@201174,33HJQ@2 NA|NA|NA MAG.T1.179_02562 1386089.N865_13000 8.7e-48 197.2 Actinobacteria ko:K07025 ko00000 Bacteria 2GN5U@201174,COG1011@1,COG1011@2 NA|NA|NA S haloacid dehalogenase MAG.T1.179_02563 1089544.KB912942_gene4783 1.7e-25 122.5 Pseudonocardiales Bacteria 2IQMV@201174,4EBME@85010,COG4978@1,COG4978@2 NA|NA|NA KT Bacterial transcription activator, effector binding domain MAG.T1.179_02564 266940.Krad_0596 4.4e-59 234.2 Actinobacteria argH GO:0003674,GO:0003824,GO:0004042,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016043,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0040007,GO:0042450,GO:0042802,GO:0042803,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,4.3.2.1 ko:K00619,ko:K14681 ko00220,ko00250,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map01100,map01110,map01130,map01210,map01230 M00028,M00029,M00844 R00259,R01086 RC00004,RC00064,RC00445,RC00447 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_0946 Bacteria 2GJBT@201174,COG1246@1,COG1246@2 NA|NA|NA E N-acetylglutamate synthase MAG.T1.179_02565 1206101.AZXC01000015_gene5031 1.9e-297 1028.5 Actinobacteria ppc GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008964,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0072350 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 iJN678.ppc,iSFV_1184.SFV_4025 Bacteria 2GKDB@201174,COG2352@1,COG2352@2 NA|NA|NA C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle MAG.T1.179_02566 479435.Kfla_6437 4.1e-24 117.5 Propionibacteriales lsr Bacteria 2C4MW@1,2IQ6A@201174,32RKK@2,4DRQX@85009 NA|NA|NA S Lsr2 MAG.T1.179_02568 1298863.AUEP01000012_gene3726 4.2e-54 218.4 Propionibacteriales tsnR 2.1.1.185 ko:K03218,ko:K03437 ko00000,ko01000,ko03009,ko03016 Bacteria 2GJI6@201174,4DQ6Y@85009,COG0566@1,COG0566@2 NA|NA|NA J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family MAG.T1.179_02569 1307761.L21SP2_0103 1.9e-114 419.9 Spirochaetes GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.2.1.1 ko:K01176 ko00500,ko01100,ko04973,map00500,map01100,map04973 R02108,R02112,R11262 ko00000,ko00001,ko01000 GH13 iLJ478.TM1840 Bacteria 2J6AH@203691,COG0366@1,COG0366@2 NA|NA|NA G PFAM Alpha amylase, catalytic domain MAG.T1.179_02570 1123320.KB889667_gene2923 4.4e-168 597.4 Actinobacteria pheS GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 2GJGG@201174,COG0016@1,COG0016@2 NA|NA|NA J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily MAG.T1.179_02571 269800.Tfu_2060 1e-260 906.4 Streptosporangiales pheT GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0019538,GO:0019752,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 2GMFD@201174,4EGYI@85012,COG0072@1,COG0072@2,COG0073@1,COG0073@2 NA|NA|NA J Ferredoxin-fold anticodon binding domain MAG.T1.179_02572 1122963.AUHB01000006_gene2514 8.9e-35 154.1 Alphaproteobacteria Bacteria 1N4Z9@1224,2UE0R@28211,COG1028@1,COG1028@2 NA|NA|NA IQ KR domain MAG.T1.179_02573 1123024.AUII01000002_gene940 5.5e-15 87.4 Pseudonocardiales Bacteria 2I8IW@201174,4EF3K@85010,COG1846@1,COG1846@2 NA|NA|NA K helix_turn_helix multiple antibiotic resistance protein MAG.T1.179_02574 1032480.MLP_44030 3.7e-171 608.2 Propionibacteriales Bacteria 2H32P@201174,4DX0H@85009,COG0477@1,COG2814@2 NA|NA|NA P Fungal trichothecene efflux pump (TRI12) MAG.T1.179_02575 351607.Acel_1263 1.9e-112 412.5 Frankiales argC GO:0000166,GO:0003674,GO:0005488,GO:0008150,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0048037,GO:0050661,GO:0050662,GO:0070401,GO:0097159,GO:1901265,GO:1901363 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKQK@201174,4ES9C@85013,COG0002@1,COG0002@2 NA|NA|NA E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde MAG.T1.179_02576 1449353.JQMQ01000005_gene936 4.3e-145 521.2 Streptacidiphilus argJ GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35,2.7.2.8 ko:K00620,ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282,R02649 RC00002,RC00004,RC00043,RC00064 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIW0@201174,2NEHP@228398,COG1364@1,COG1364@2 NA|NA|NA E ArgJ family MAG.T1.179_02577 28042.GU90_13915 7.8e-110 403.7 Pseudonocardiales argB GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0030312,GO:0031406,GO:0034618,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS10565,iJN678.argB,iLJ478.TM1784 Bacteria 2GKDS@201174,4DXB3@85010,COG0548@1,COG0548@2 NA|NA|NA E Belongs to the acetylglutamate kinase family. ArgB subfamily MAG.T1.179_02578 644283.Micau_2374 3.8e-128 464.9 Micromonosporales argD GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0008150,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 2GKE9@201174,4DBFJ@85008,COG4992@1,COG4992@2 NA|NA|NA E acetylornithine aminotransferase MAG.T1.179_02579 1288083.AUKR01000003_gene3698 1.5e-43 182.6 Actinobacteria argR GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 ko:K03402 ko00000,ko03000 Bacteria 2GKA5@201174,COG1438@1,COG1438@2 NA|NA|NA K Regulates arginine biosynthesis genes MAG.T1.179_02580 1155718.KB891898_gene1918 7.5e-177 626.7 Actinobacteria argG GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0071944,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 iNJ661.Rv1658 Bacteria 2GK96@201174,COG0137@1,COG0137@2 NA|NA|NA E Belongs to the argininosuccinate synthase family. Type MAG.T1.179_02581 1120950.KB892768_gene5196 1.7e-183 649.0 Propionibacteriales argH GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0030312,GO:0040007,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 iJN678.argH Bacteria 2GJ2A@201174,4DPEP@85009,COG0165@1,COG0165@2 NA|NA|NA E argininosuccinate lyase MAG.T1.179_02582 1440053.JOEI01000018_gene518 1.3e-147 529.6 Actinobacteria tyrS GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0030312,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 Bacteria 2GJPR@201174,COG0162@1,COG0162@2 NA|NA|NA J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) MAG.T1.179_02583 351607.Acel_0079 5.1e-32 144.1 Bacteria yacL GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 Bacteria COG4956@1,COG4956@2 NA|NA|NA S nuclease activity MAG.T1.179_02584 862751.SACTE_3674 9.5e-47 193.7 Actinobacteria ispD GO:0000166,GO:0000287,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016020,GO:0016114,GO:0016740,GO:0016772,GO:0016779,GO:0019103,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0032787,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044464,GO:0046490,GO:0046872,GO:0046914,GO:0050518,GO:0051483,GO:0051484,GO:0070567,GO:0071704,GO:0071944,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.405,2.7.7.40,2.7.7.60,4.6.1.12 ko:K00991,ko:K12506,ko:K21681 ko00040,ko00900,ko01100,ko01110,ko01130,map00040,map00900,map01100,map01110,map01130 M00096 R01525,R02921,R05633,R05637 RC00002,RC00089,RC01440 ko00000,ko00001,ko00002,ko01000 Bacteria 2GNHP@201174,COG1211@1,COG1211@2 NA|NA|NA I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) MAG.T1.179_02585 390989.JOEG01000009_gene1007 3.6e-56 224.6 Micromonosporales ispF GO:0003674,GO:0003824,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008685,GO:0009058,GO:0009987,GO:0016114,GO:0016829,GO:0016849,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0051483,GO:0071704,GO:1901576 2.1.1.228,2.7.7.60,4.6.1.12 ko:K00554,ko:K01770,ko:K12506 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R00597,R05633,R05637 RC00002,RC00003,RC00334,RC01440 ko00000,ko00001,ko00002,ko01000,ko03016 iNJ661.Rv3581c Bacteria 2II8H@201174,4DDC4@85008,COG0245@1,COG0245@2 NA|NA|NA I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) MAG.T1.179_02586 446468.Ndas_4314 2.8e-159 568.5 Streptosporangiales cysS GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16,6.3.1.13 ko:K01883,ko:K15526 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 2GJF2@201174,4EFX4@85012,COG0215@1,COG0215@2 NA|NA|NA J DALR_2 MAG.T1.179_02587 66377.JOBH01000005_gene2852 5.1e-96 357.8 Actinobacteria rlmB GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.185 ko:K03218 ko00000,ko01000,ko03009 Bacteria 2GJMR@201174,COG0566@1,COG0566@2 NA|NA|NA J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family MAG.T1.179_02588 1123073.KB899241_gene2314 1.4e-28 133.7 Xanthomonadales 3.2.1.20 ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 GH31 Bacteria 1RAB4@1224,1S2JK@1236,1X7DU@135614,COG0366@1,COG0366@2,COG2819@1,COG2819@2 NA|NA|NA G Putative esterase MAG.T1.179_02589 1380354.JIAN01000005_gene2883 2e-124 452.6 Cellulomonadaceae inaA ko:K02848 ko00540,ko01100,map00540,map01100 M00080 ko00000,ko00001,ko00002,ko01000,ko01005 Bacteria 2GIX0@201174,4F13Z@85016,COG3642@1,COG3642@2 NA|NA|NA T Domain of unknown function (DUF4032) MAG.T1.179_02591 479431.Namu_4682 4.7e-159 568.2 Actinobacteria malZ GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0004558,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009311,GO:0009313,GO:0009987,GO:0015926,GO:0016052,GO:0016787,GO:0016798,GO:0030978,GO:0030980,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044464,GO:0051691,GO:0051692,GO:0071704,GO:0090599,GO:1901575 3.2.1.20 ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 GH31 iECH74115_1262.ECH74115_0480,iEcSMS35_1347.EcSMS35_0434,iSFV_1184.SFV_0368,iYL1228.KPN_00344 Bacteria 2GJUT@201174,COG0366@1,COG0366@2 NA|NA|NA G alpha amylase, catalytic MAG.T1.179_02592 479431.Namu_4683 4e-175 620.9 Frankiales ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 ko00000,ko00001,ko00002,ko02000 3.A.1.1 Bacteria 2GJCM@201174,4ES4E@85013,COG3842@1,COG3842@2 NA|NA|NA P Belongs to the ABC transporter superfamily MAG.T1.179_02593 1095767.CAHD01000191_gene271 1.2e-168 600.1 Cellulomonadaceae malZ GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0004558,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009311,GO:0009313,GO:0009987,GO:0015926,GO:0016052,GO:0016787,GO:0016798,GO:0030978,GO:0030980,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044464,GO:0051691,GO:0051692,GO:0071704,GO:0090599,GO:1901575 3.2.1.20 ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 GH31 iECH74115_1262.ECH74115_0480,iEcSMS35_1347.EcSMS35_0434,iSFV_1184.SFV_0368,iYL1228.KPN_00344 Bacteria 2GJUT@201174,4F26G@85016,COG0366@1,COG0366@2 NA|NA|NA G Alpha-amylase domain MAG.T1.179_02594 479431.Namu_4684 5.3e-122 444.1 Actinobacteria malG GO:0003674,GO:0003824,GO:0005215,GO:0005363,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015154,GO:0015157,GO:0015399,GO:0015405,GO:0015422,GO:0015423,GO:0015766,GO:0015768,GO:0015772,GO:0015774,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033037,GO:0034219,GO:0042623,GO:0042626,GO:0042956,GO:0043190,GO:0043211,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990060,GO:1990351 ko:K10110,ko:K15772 ko02010,map02010 M00194,M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1.1,3.A.1.1.16,3.A.1.1.2,3.A.1.1.22 iLJ478.TM1202,iSSON_1240.SSON_4210,iYL1228.KPN_04421 Bacteria 2I2EZ@201174,COG3833@1,COG3833@2 NA|NA|NA P PFAM binding-protein-dependent transport systems inner membrane component MAG.T1.179_02595 479431.Namu_4685 1.7e-208 732.3 Actinobacteria malF GO:0003674,GO:0003824,GO:0005215,GO:0005363,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006950,GO:0006974,GO:0008150,GO:0008643,GO:0009987,GO:0015144,GO:0015154,GO:0015157,GO:0015399,GO:0015405,GO:0015422,GO:0015423,GO:0015766,GO:0015768,GO:0015772,GO:0015774,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033037,GO:0033554,GO:0034219,GO:0042623,GO:0042626,GO:0042956,GO:0043190,GO:0043211,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990060,GO:1990351 ko:K02025,ko:K10109,ko:K10118,ko:K10233,ko:K15771 ko02010,map02010 M00194,M00196,M00201,M00207,M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.1,3.A.1.1.16,3.A.1.1.2,3.A.1.1.22,3.A.1.1.28,3.A.1.1.32,3.A.1.1.8 iZ_1308.Z5631 Bacteria 2GJGB@201174,COG1175@1,COG1175@2 NA|NA|NA G PFAM binding-protein-dependent transport systems inner membrane component MAG.T1.179_02596 479431.Namu_4686 1.1e-125 456.8 Bacteria ko:K02027,ko:K15770 ko02010,map02010 M00207,M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.2 Bacteria COG2182@1,COG2182@2 NA|NA|NA G maltose binding MAG.T1.179_02597 1001240.GY21_16135 1.2e-52 214.2 Microbacteriaceae ko:K02027,ko:K15770 ko02010,map02010 M00207,M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.2 Bacteria 2HSEH@201174,4FMZA@85023,COG2182@1,COG2182@2 NA|NA|NA G Bacterial extracellular solute-binding protein MAG.T1.179_02598 1961.JOAK01000011_gene5882 1.4e-37 162.2 Actinobacteria glnB ko:K04751 ko02020,map02020 ko00000,ko00001 Bacteria 2IKN1@201174,COG0347@1,COG0347@2 NA|NA|NA K Belongs to the P(II) protein family MAG.T1.179_02599 1120950.KB892769_gene5401 1.3e-142 513.1 Propionibacteriales amt GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03320 ko00000,ko02000 1.A.11 iNJ661.Rv2920c Bacteria 2GIZK@201174,4DNW9@85009,COG0004@1,COG0004@2 NA|NA|NA P Ammonium Transporter Family MAG.T1.179_02602 1236902.ANAS01000006_gene5183 2e-58 233.8 Actinobacteria Bacteria 2GIV0@201174,COG0515@1,COG0515@2 NA|NA|NA KLT serine threonine protein kinase MAG.T1.179_02603 227882.SAV_5 1.7e-10 73.2 Actinobacteria Bacteria 2ARC3@1,2IAHR@201174,31GN3@2 NA|NA|NA MAG.T1.179_02604 644548.SCNU_00065 1.9e-33 150.2 Gordoniaceae Bacteria 2GMMI@201174,4GD92@85026,COG0582@1,COG0582@2 NA|NA|NA L Belongs to the 'phage' integrase family MAG.T1.179_02607 1463864.JOGO01000020_gene3357 1.1e-93 349.7 Actinobacteria ugd 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJQB@201174,COG1004@1,COG1004@2 NA|NA|NA M Belongs to the UDP-glucose GDP-mannose dehydrogenase family MAG.T1.179_02612 134676.ACPL_5940 3.7e-28 132.1 Micromonosporales dnaG ko:K02316 ko03030,map03030 ko00000,ko00001,ko01000,ko03032 Bacteria 2IIZM@201174,4DH41@85008,COG0358@1,COG0358@2 NA|NA|NA L Toprim-like MAG.T1.179_02613 263358.VAB18032_30319 1.4e-12 81.3 Micromonosporales Bacteria 2DRVP@1,2GQDR@201174,33D9Z@2,4DE7K@85008 NA|NA|NA MAG.T1.179_02614 397278.JOJN01000013_gene2576 3.4e-22 112.1 Propionibacteriales Bacteria 2HKN7@201174,4DQJH@85009,COG1261@1,COG1261@2 NA|NA|NA NO SAF MAG.T1.179_02615 1385519.N801_09650 2.3e-46 192.6 Intrasporangiaceae Bacteria 2HT5K@201174,4FI0R@85021,COG0455@1,COG0455@2 NA|NA|NA D bacterial-type flagellum organization MAG.T1.179_02616 313589.JNB_00780 3.4e-91 342.4 Intrasporangiaceae ko:K02283 ko00000,ko02035,ko02044 Bacteria 2GKKJ@201174,4FGGW@85021,COG4962@1,COG4962@2 NA|NA|NA U Type II/IV secretion system protein MAG.T1.179_02617 1385519.N801_09660 6.4e-82 310.8 Intrasporangiaceae Bacteria 2GN6E@201174,4FHCH@85021,COG4965@1,COG4965@2 NA|NA|NA U Type II secretion system (T2SS), protein F MAG.T1.179_02618 313589.JNB_00790 4.2e-60 238.4 Intrasporangiaceae ko:K12511 ko00000,ko02044 Bacteria 2HZTC@201174,4FHX4@85021,COG2064@1,COG2064@2 NA|NA|NA NU Type II secretion system (T2SS), protein F MAG.T1.179_02622 446471.Xcel_3428 5.2e-45 188.3 Promicromonosporaceae Bacteria 2DVVA@1,2IHH0@201174,32V07@2,4F5R6@85017 NA|NA|NA MAG.T1.179_02623 313589.JNB_00805 1.6e-17 95.9 Intrasporangiaceae Bacteria 2GRCJ@201174,4FI3I@85021,COG4961@1,COG4961@2 NA|NA|NA U TadE-like protein MAG.T1.179_02624 1137268.AZXF01000033_gene3448 1.7e-16 92.4 Streptosporangiales Bacteria 2AQHK@1,2I1FE@201174,31FQ6@2,4EK4S@85012 NA|NA|NA S Putative Flp pilus-assembly TadE/G-like MAG.T1.179_02625 1035308.AQYY01000002_gene68 6.1e-28 131.7 Bacteria Bacteria COG1652@1,COG1652@2,COG3170@1,COG3170@2 NA|NA|NA S positive regulation of growth rate MAG.T1.179_02628 1121019.AUMN01000020_gene1650 1.6e-52 212.6 Micrococcaceae Bacteria 1WCG3@1268,2I3S1@201174,COG1476@1,COG1476@2 NA|NA|NA K Helix-turn-helix XRE-family like proteins MAG.T1.179_02629 1223523.H340_07753 7.2e-71 273.9 Actinobacteria Bacteria 2GMX2@201174,COG3382@1,COG3382@2 NA|NA|NA S B3 4 domain MAG.T1.179_02630 1298863.AUEP01000020_gene3640 1e-37 162.5 Actinobacteria 2.3.1.128 ko:K03790 ko00000,ko01000,ko03009 Bacteria 2IQZC@201174,COG2329@1,COG2329@2 NA|NA|NA S Antibiotic biosynthesis monooxygenase MAG.T1.179_02632 1348338.ADILRU_1152 2.6e-25 120.9 Microbacteriaceae Bacteria 2C7CU@1,2IRTH@201174,33J7G@2,4FSJC@85023 NA|NA|NA MAG.T1.179_02633 1385520.N802_11490 1.2e-28 132.1 Intrasporangiaceae Bacteria 2E8MQ@1,2ISX4@201174,332Z5@2,4FHDD@85021 NA|NA|NA S Ribbon-helix-helix protein, copG family MAG.T1.179_02634 1380370.JIBA01000011_gene3047 1.2e-150 539.3 Intrasporangiaceae ko:K04763 ko00000,ko03036 Bacteria 2ID5W@201174,4FFEX@85021,COG4974@1,COG4974@2 NA|NA|NA L Belongs to the 'phage' integrase family MAG.T1.179_02635 1380356.JNIK01000018_gene606 2.3e-44 187.6 Frankiales Bacteria 2GKF3@201174,4ETTR@85013,COG0577@1,COG0577@2 NA|NA|NA V FtsX-like permease family MAG.T1.179_02636 1120936.KB907222_gene2285 2.2e-78 298.9 Streptosporangiales lolD ko:K02003 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GM25@201174,4EIIZ@85012,COG1136@1,COG1136@2 NA|NA|NA V ATPases associated with a variety of cellular activities MAG.T1.179_02637 1449976.KALB_8405 1.3e-40 172.9 Pseudonocardiales Bacteria 2GNA1@201174,4DXC5@85010,COG1695@1,COG1695@2 NA|NA|NA K Transcriptional regulator MAG.T1.179_02638 1121019.AUMN01000004_gene1337 1.2e-07 63.5 Micrococcaceae Bacteria 1WAGS@1268,2DRTH@1,2GY6H@201174,33CZB@2 NA|NA|NA MAG.T1.179_02639 1123320.KB889596_gene8626 1.5e-17 96.3 Actinobacteria ko:K03088 ko00000,ko03021 Bacteria 2IKVM@201174,COG1595@1,COG1595@2 NA|NA|NA K belongs to the sigma-70 factor family, ECF subfamily MAG.T1.179_02644 1110697.NCAST_10_00400 3.4e-56 225.3 Nocardiaceae Bacteria 2GKI2@201174,4FYFT@85025,COG1028@1,COG1028@2 NA|NA|NA IQ Belongs to the short-chain dehydrogenases reductases (SDR) family MAG.T1.179_02645 1122609.AUGT01000021_gene1209 3.9e-59 234.2 Propionibacteriales Bacteria 2ISFT@201174,4DR3H@85009,COG2315@1,COG2315@2 NA|NA|NA S YjbR MAG.T1.179_02647 743718.Isova_2573 9.5e-25 120.9 Promicromonosporaceae Bacteria 2ERYQ@1,2GXQP@201174,33JHV@2,4F4YJ@85017 NA|NA|NA MAG.T1.179_02648 593907.Celgi_0953 7.7e-24 116.7 Cellulomonadaceae ko:K07979 ko00000,ko03000 Bacteria 2IQEW@201174,4F2NR@85016,COG1725@1,COG1725@2 NA|NA|NA K Helix-turn-helix domain MAG.T1.179_02650 1184609.KILIM_003_01140 1e-37 162.5 Actinobacteria Bacteria 2IRSY@201174,COG3657@1,COG3657@2 NA|NA|NA S addiction module killer protein MAG.T1.179_02651 1184609.KILIM_003_01150 2.5e-41 174.5 Actinobacteria Bacteria 2IRAI@201174,COG3636@1,COG3636@2 NA|NA|NA K Addiction module MAG.T1.179_02652 1146883.BLASA_2088 6.5e-90 337.0 Frankiales sucB 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2GMUV@201174,4ERCG@85013,COG0508@1,COG0508@2 NA|NA|NA C TIGRFAM 2-oxoglutarate dehydrogenase, E2 component MAG.T1.179_02653 1169154.KB897783_gene4646 2e-102 379.0 Actinobacteria GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006066,GO:0006629,GO:0006706,GO:0006707,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008395,GO:0009056,GO:0016020,GO:0016042,GO:0016125,GO:0016127,GO:0016491,GO:0016705,GO:0016709,GO:0020037,GO:0030312,GO:0031073,GO:0036199,GO:0044238,GO:0044281,GO:0044282,GO:0044464,GO:0046164,GO:0046906,GO:0048037,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1901615,GO:1901616,GO:1902652 ko:K07071 ko00000 Bacteria 2GJS0@201174,COG1090@1,COG1090@2 NA|NA|NA S epimerase MAG.T1.179_02655 1464048.JNZS01000006_gene4063 3.4e-72 278.1 Micromonosporales lipB GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0033819,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0071944,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.3.1.181 ko:K03801 ko00785,ko01100,map00785,map01100 R07766,R07769 RC00039,RC00992,RC02867 ko00000,ko00001,ko01000 Bacteria 2GJIX@201174,4DADI@85008,COG0321@1,COG0321@2 NA|NA|NA H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate MAG.T1.179_02656 1077974.GOEFS_009_00220 2.4e-135 488.4 Gordoniaceae lipA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 R07767,R07768 RC01978 ko00000,ko00001,ko01000 Bacteria 2GKD4@201174,4GBJ4@85026,COG0320@1,COG0320@2 NA|NA|NA H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives MAG.T1.179_02657 1123319.AUBE01000003_gene975 1.6e-51 209.5 Actinobacteria GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 Bacteria 2AUFS@1,2GIXC@201174,31K3Y@2 NA|NA|NA S Domain of unknown function (DUF4191) MAG.T1.179_02658 479433.Caci_6340 7.8e-93 347.4 Actinobacteria Bacteria 2GIRA@201174,COG4977@1,COG4977@2 NA|NA|NA K Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain MAG.T1.179_02660 1121017.AUFG01000001_gene2901 5.5e-27 127.5 Intrasporangiaceae Bacteria 2IQMG@201174,4FHT2@85021,COG1714@1,COG1714@2 NA|NA|NA S PFAM RDD domain containing protein MAG.T1.179_02661 1449347.JQLN01000007_gene1653 2.3e-46 193.4 Kitasatospora Bacteria 2GKEJ@201174,2M1IE@2063,COG1432@1,COG1432@2 NA|NA|NA S NYN domain MAG.T1.179_02662 1048339.KB913029_gene4661 3.3e-232 810.8 Frankiales glnA GO:0001968,GO:0003674,GO:0003824,GO:0004356,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009405,GO:0009605,GO:0009607,GO:0009893,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016020,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019222,GO:0019752,GO:0019899,GO:0020012,GO:0030162,GO:0030312,GO:0030682,GO:0031323,GO:0031325,GO:0032268,GO:0032270,GO:0035375,GO:0040007,GO:0043207,GO:0043436,GO:0044044,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046394,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0070613,GO:0071704,GO:0071944,GO:0075136,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1903317,GO:1903319 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 Bacteria 2GMN1@201174,4ES5H@85013,COG0174@1,COG0174@2 NA|NA|NA E TIGRFAM glutamine synthetase, type I MAG.T1.179_02663 996637.SGM_1410 5.5e-105 389.8 Actinobacteria Bacteria 2GQIV@201174,COG5635@1,COG5635@2 NA|NA|NA T Nacht domain MAG.T1.179_02664 367299.JOEE01000003_gene2916 5.4e-41 173.3 Intrasporangiaceae higA ko:K21498 ko00000,ko02048 Bacteria 2IR2S@201174,4FHGX@85021,COG3093@1,COG3093@2 NA|NA|NA K Helix-turn-helix XRE-family like proteins MAG.T1.179_02665 710696.Intca_2901 1.5e-38 165.2 Intrasporangiaceae higB ko:K07334 ko00000,ko02048 Bacteria 2HVCI@201174,4FJJ2@85021,COG3549@1,COG3549@2 NA|NA|NA S RelE-like toxin of type II toxin-antitoxin system HigB MAG.T1.179_02667 67352.JODS01000008_gene7343 1.8e-11 76.3 Actinobacteria Bacteria 2IPJR@201174,COG0640@1,COG0640@2 NA|NA|NA K helix_turn_helix, Arsenical Resistance Operon Repressor MAG.T1.179_02668 1449353.JQMQ01000005_gene829 2e-121 442.2 Streptacidiphilus fmt GO:0003674,GO:0003824,GO:0004479,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006418,GO:0006431,GO:0006464,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019752,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.1.176,2.1.2.9 ko:K00604,ko:K03500 ko00670,ko00970,map00670,map00970 R03940 RC00026,RC00165 ko00000,ko00001,ko01000,ko03009 iECABU_c1320.ECABU_c37050,iECUMN_1333.ECUMN_3761,ic_1306.c4048 Bacteria 2GKH5@201174,2NH3A@228398,COG0223@1,COG0223@2 NA|NA|NA J Formyl transferase, C-terminal domain MAG.T1.179_02669 2045.KR76_14595 4e-110 405.2 Propionibacteriales sun GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.176,5.3.1.9 ko:K01810,ko:K03500 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko03009,ko04147 Bacteria 2GM21@201174,4DP4E@85009,COG0144@1,COG0144@2,COG0781@1,COG0781@2 NA|NA|NA JK Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family MAG.T1.179_02670 1048339.KB913029_gene4006 1.2e-88 332.8 Frankiales rpe GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJZ9@201174,4ERMA@85013,COG0036@1,COG0036@2 NA|NA|NA G Belongs to the ribulose-phosphate 3-epimerase family MAG.T1.179_02671 743718.Isova_1506 1.9e-104 386.0 Promicromonosporaceae ribD GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0008703,GO:0008835,GO:0009058,GO:0009110,GO:0009231,GO:0009451,GO:0009987,GO:0016020,GO:0016070,GO:0016491,GO:0016614,GO:0016616,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0034641,GO:0036094,GO:0040007,GO:0042364,GO:0042726,GO:0042727,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.1.1.193,3.5.4.26 ko:K01498,ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1624,iB21_1397.B21_00366,iECBD_1354.ECBD_3247,iECB_1328.ECB_00362,iECD_1391.ECD_00362,iECED1_1282.ECED1_0437,iECNA114_1301.ECNA114_0391,iECSF_1327.ECSF_0374,iEcolC_1368.EcolC_3219,iJN746.PP_0514,iLF82_1304.LF82_1880,iLJ478.TM1828,iNRG857_1313.NRG857_01945,iYL1228.KPN_00366,ic_1306.c0524 Bacteria 2GKAX@201174,4F42N@85017,COG0117@1,COG0117@2,COG1985@1,COG1985@2 NA|NA|NA H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate MAG.T1.179_02672 1449355.JQNR01000005_gene5307 4.2e-64 251.1 Actinobacteria ribE GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.9,3.5.4.25,4.1.99.12 ko:K00793,ko:K02858,ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00066,R00425,R07281 RC00293,RC00958,RC00960,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS08950 Bacteria 2GKC5@201174,COG0307@1,COG0307@2 NA|NA|NA H riboflavin synthase, alpha MAG.T1.179_02673 1123320.KB889596_gene8708 2.5e-152 545.4 Actinobacteria ribBA 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIWJ@201174,COG0108@1,COG0108@2,COG0807@1,COG0807@2 NA|NA|NA H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate MAG.T1.179_02674 1115803.HMPREF1129_0933 6.9e-50 203.8 Actinobacteria ribH 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 Bacteria 2II1Z@201174,4D5BA@85005,COG0054@1,COG0054@2 NA|NA|NA H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin MAG.T1.179_02675 1121946.AUAX01000008_gene7170 6.2e-28 129.8 Micromonosporales hisE GO:0000105,GO:0000287,GO:0003674,GO:0003824,GO:0004635,GO:0004636,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0043167,GO:0043169,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052803,GO:0071704,GO:0071944,GO:0075136,GO:0075139,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.4.19,3.6.1.31,5.3.1.16 ko:K01523,ko:K01814,ko:K11755 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035,R04037,R04640 RC00002,RC00945,RC01055 ko00000,ko00001,ko00002,ko01000 iECNA114_1301.ECNA114_0880,iECW_1372.ECW_m2186,iEKO11_1354.EKO11_1768,iSB619.SA_RS14110,iUMN146_1321.UM146_06665,iWFL_1372.ECW_m2186,iYO844.BSU34860 Bacteria 2IQ4D@201174,4DF5K@85008,COG0140@1,COG0140@2 NA|NA|NA E Phosphoribosyl-ATP MAG.T1.179_02676 1120950.KB892707_gene4712 1e-92 346.7 Propionibacteriales hisG GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 Bacteria 2GNAX@201174,4DNZB@85009,COG0040@1,COG0040@2 NA|NA|NA E ATP phosphoribosyltransferase MAG.T1.179_02677 543632.JOJL01000005_gene4762 2.8e-23 114.8 Actinobacteria Bacteria 2I2Z1@201174,COG0745@1,COG0745@2 NA|NA|NA T Response regulator receiver MAG.T1.179_02678 543632.JOJL01000005_gene4760 1.8e-110 407.1 Actinobacteria Bacteria 2I2TP@201174,COG5002@1,COG5002@2 NA|NA|NA T Histidine kinase MAG.T1.179_02679 543632.JOJL01000005_gene4761 6.3e-71 275.4 Micromonosporales aprX ko:K17734 ko00000,ko01000,ko01002 Bacteria 2IAS7@201174,4DHP7@85008,COG1404@1,COG1404@2 NA|NA|NA O Peptidase S8 and S53 subtilisin kexin sedolisin MAG.T1.179_02680 1348663.KCH_66760 2.1e-77 296.6 Kitasatospora accD GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009059,GO:0009273,GO:0009987,GO:0016020,GO:0016053,GO:0019752,GO:0032787,GO:0034645,GO:0042546,GO:0043170,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070589,GO:0071554,GO:0071704,GO:0071766,GO:0071767,GO:0071768,GO:0071840,GO:0071944,GO:0072330,GO:1901576 2.1.3.15,6.4.1.2 ko:K01962,ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 Bacteria 2GNP7@201174,2M0IK@2063,COG0777@1,COG0777@2,COG0825@1,COG0825@2 NA|NA|NA I Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit MAG.T1.179_02681 1123052.AUDF01000011_gene1510 6.1e-15 88.2 Microbacteriaceae hisA GO:0000105,GO:0003674,GO:0003824,GO:0003949,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.4.19,3.6.1.31,5.3.1.16,5.3.1.24 ko:K01814,ko:K01817,ko:K11755 ko00340,ko00400,ko01100,ko01110,ko01130,ko01230,map00340,map00400,map01100,map01110,map01130,map01230 M00023,M00026 R03509,R04035,R04037,R04640 RC00002,RC00945,RC01055 ko00000,ko00001,ko00002,ko01000 Bacteria 2I4YY@201174,4FKW9@85023,COG0106@1,COG0106@2 NA|NA|NA E SseB protein N-terminal domain MAG.T1.179_02682 452652.KSE_15250 1.2e-37 162.5 Kitasatospora Bacteria 2AI3Y@1,2IHSQ@201174,2M2YX@2063,318HW@2 NA|NA|NA MAG.T1.179_02683 1184607.AUCHE_01_00170 1.7e-64 252.3 Dermatophilaceae infC GO:0000049,GO:0001731,GO:0002181,GO:0002183,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006417,GO:0006446,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016020,GO:0016043,GO:0019222,GO:0019538,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032268,GO:0032270,GO:0032790,GO:0032984,GO:0032988,GO:0032991,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043254,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045727,GO:0045948,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065003,GO:0065007,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901193,GO:1901195,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:1904688,GO:1904690,GO:1990856,GO:1990904,GO:2000112,GO:2000765,GO:2000767 ko:K02520 ko00000,ko03012,ko03029 Bacteria 2GJGT@201174,4F6SW@85018,COG0290@1,COG0290@2 NA|NA|NA J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins MAG.T1.179_02684 1122130.AUHN01000006_gene2126 8.5e-14 82.4 Actinobacteria rpmI GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 ko:K02916 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GQZW@201174,COG0291@1,COG0291@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL35 family MAG.T1.179_02685 1120950.KB892823_gene569 4.6e-196 690.6 Propionibacteriales phoH ko:K07175 ko00000 Bacteria 2GK8U@201174,4DNRD@85009,COG1875@1,COG1875@2 NA|NA|NA T phosphate starvation-inducible protein PhoH MAG.T1.179_02686 1449355.JQNR01000005_gene3991 7.9e-100 370.2 Actinobacteria uppS 2.5.1.31,2.5.1.68 ko:K00806,ko:K12503 ko00900,ko01110,map00900,map01110 R06447,R08528 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 Bacteria 2GJCP@201174,COG0020@1,COG0020@2 NA|NA|NA I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids MAG.T1.179_02687 1121385.AQXW01000001_gene776 1.9e-54 219.2 Dermacoccaceae yplQ ko:K11068 ko00000,ko02042 Bacteria 1ZW8F@145357,2GJGQ@201174,COG1272@1,COG1272@2 NA|NA|NA S hemolysin III MAG.T1.179_02688 644283.Micau_2172 2.4e-91 342.0 Micromonosporales xth 3.1.11.2,6.5.1.1 ko:K01142,ko:K01971 ko03410,ko03450,map03410,map03450 R00381 RC00005 ko00000,ko00001,ko01000,ko03400 Bacteria 2GKEW@201174,4D92U@85008,COG0708@1,COG0708@2 NA|NA|NA L exodeoxyribonuclease III MAG.T1.179_02689 1894.JOER01000030_gene416 1.4e-37 163.3 Actinobacteria Bacteria 2GMRP@201174,COG4758@1,COG4758@2 NA|NA|NA S Cell wall-active antibiotics response 4TMS YvqF MAG.T1.179_02690 369723.Strop_3578 3.9e-14 84.3 Micromonosporales GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 Bacteria 2E65S@1,2IMEQ@201174,330UF@2,4DERM@85008 NA|NA|NA S Domain of unknown function (DUF3817) MAG.T1.179_02691 1210045.ALNP01000011_gene1032 3.6e-25 122.1 Actinobacteria surf1 ko:K14998 ko00000,ko03029 3.D.4.8 Bacteria 2GMGB@201174,COG3346@1,COG3346@2 NA|NA|NA S SURF1-like protein MAG.T1.179_02693 994479.GL877878_gene2035 1.4e-12 79.7 Pseudonocardiales Bacteria 2DRBP@1,2IGPY@201174,33B4I@2,4E5JR@85010 NA|NA|NA S Domain of unknown function (DUF4307) MAG.T1.179_02694 1504319.GM45_3100 5.2e-44 184.1 unclassified Actinobacteria (class) greA GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006354,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0030312,GO:0031323,GO:0031326,GO:0032774,GO:0032784,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 ko:K03624 ko00000,ko03021 Bacteria 2GNZV@201174,3UWPU@52018,COG0782@1,COG0782@2 NA|NA|NA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides MAG.T1.179_02695 526225.Gobs_0935 1.6e-131 476.1 Frankiales ilvA 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 iLJ478.TM0356 Bacteria 2GJAG@201174,4ES0N@85013,COG1171@1,COG1171@2 NA|NA|NA E PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit MAG.T1.179_02696 1435356.Y013_00880 6.6e-93 347.1 Nocardiaceae ung GO:0003674,GO:0003824,GO:0004844,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0097510,GO:0140097,GO:1901360 3.2.2.27 ko:K03648 ko03410,ko05340,map03410,map05340 ko00000,ko00001,ko01000,ko03400 Bacteria 2GJ9Z@201174,4FXPC@85025,COG0692@1,COG0692@2 NA|NA|NA L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine MAG.T1.179_02697 1122622.ATWJ01000012_gene1048 7.4e-109 401.0 Intrasporangiaceae ftsA ko:K03590 ko04112,map04112 ko00000,ko00001,ko03036,ko04812 Bacteria 2GK4G@201174,4FFED@85021,COG0849@1,COG0849@2 NA|NA|NA D Glutamate mutase MAG.T1.179_02698 287986.DV20_10395 8e-60 238.0 Pseudonocardiales ko:K02027,ko:K17329 ko02010,map02010 M00207,M00606 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.33 Bacteria 2GKM8@201174,4DYH5@85010,COG1653@1,COG1653@2 NA|NA|NA G Bacterial extracellular solute-binding protein MAG.T1.179_02699 743718.Isova_2471 5.4e-68 264.2 Promicromonosporaceae msrA 1.8.4.11 ko:K07304 ko00000,ko01000 Bacteria 2GJ1S@201174,4F34W@85017,COG0225@1,COG0225@2 NA|NA|NA O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine MAG.T1.179_02700 1048339.KB913029_gene142 3e-52 212.2 Frankiales Bacteria 2GMVS@201174,4ESHM@85013,COG2755@1,COG2755@2 NA|NA|NA E GDSL-like Lipase/Acylhydrolase MAG.T1.179_02702 479433.Caci_0641 9.9e-22 109.0 Actinobacteria Bacteria 2E5A7@1,2IQ7Z@201174,3302F@2 NA|NA|NA S Domain of unknown function (DUF4287) MAG.T1.179_02703 593907.Celgi_0646 4.4e-46 191.8 Cellulomonadaceae ko:K06377 ko00000 Bacteria 2GNCK@201174,4F210@85016,COG4760@1,COG4760@2 NA|NA|NA S Bax inhibitor 1 like MAG.T1.179_02704 1120949.KB903301_gene6329 2.5e-106 392.1 Micromonosporales Bacteria 2GP09@201174,4D8JX@85008,COG0111@1,COG0111@2 NA|NA|NA EH D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding MAG.T1.179_02705 1449346.JQMO01000003_gene5623 1.1e-59 237.7 Kitasatospora 2.7.13.3 ko:K07778 ko02020,map02020 M00479 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 2GKJJ@201174,2M2QI@2063,COG3463@1,COG3463@2 NA|NA|NA S Predicted membrane protein (DUF2079) MAG.T1.179_02708 1454004.AW11_02902 1e-84 319.7 Betaproteobacteria tniR Bacteria 1MXXT@1224,2VJ32@28216,COG1961@1,COG1961@2 NA|NA|NA L Resolvase, N terminal domain MAG.T1.179_02709 266264.Rmet_3008 9.3e-87 327.4 Burkholderiaceae tniQ Bacteria 1K4K9@119060,1PE75@1224,2C5W7@1,2VM9N@28216,2Z8WC@2 NA|NA|NA S TniQ MAG.T1.179_02710 1184609.KILIM_005_00620 5.6e-116 424.1 Bacteria clpB ko:K03695 ko04213,map04213 ko00000,ko00001,ko03110 Bacteria COG0542@1,COG0542@2 NA|NA|NA O response to heat MAG.T1.179_02711 1184609.KILIM_005_00630 4.1e-142 511.1 Actinobacteria tniA ko:K07497 ko00000 Bacteria 2IPDN@201174,COG2801@1,COG2801@2 NA|NA|NA L Mu transposase, C-terminal MAG.T1.179_02713 710696.Intca_3496 3.3e-50 204.1 Intrasporangiaceae ko:K07171 ko00000,ko01000,ko02048 Bacteria 2HY4S@201174,4FJRX@85021,COG2337@1,COG2337@2 NA|NA|NA L PemK-like, MazF-like toxin of type II toxin-antitoxin system MAG.T1.179_02714 1184609.KILIM_074_00180 1.1e-21 108.6 Actinobacteria Bacteria 2FF53@1,2H9GT@201174,34737@2 NA|NA|NA MAG.T1.179_02715 710696.Intca_3499 6.1e-163 580.5 Intrasporangiaceae Bacteria 2GS79@201174,4FFP0@85021,COG3547@1,COG3547@2 NA|NA|NA L Transposase MAG.T1.179_02717 1380370.JIBA01000015_gene330 9e-26 122.9 Actinobacteria Bacteria 2IRGU@201174,COG1846@1,COG1846@2 NA|NA|NA K transcriptional MAG.T1.179_02719 710696.Intca_0352 6.5e-50 203.4 Intrasporangiaceae ko:K07341 ko00000,ko02048 Bacteria 2IR34@201174,4FHP3@85021,COG3654@1,COG3654@2 NA|NA|NA S Fic/DOC family MAG.T1.179_02720 1386089.N865_20845 4.2e-21 106.7 Bacteria Bacteria 2EM5W@1,33EV5@2 NA|NA|NA MAG.T1.179_02721 1193181.BN10_1280004 1.7e-47 195.7 Intrasporangiaceae Bacteria 2IFJT@201174,4FGZW@85021,COG3832@1,COG3832@2 NA|NA|NA S Polyketide cyclase / dehydrase and lipid transport MAG.T1.179_02722 861360.AARI_35180 2.9e-115 422.2 Micrococcaceae Bacteria 1WB05@1268,2GJK7@201174,COG3464@1,COG3464@2 NA|NA|NA L 4.5 Transposon and IS MAG.T1.179_02723 767817.Desgi_0838 2.4e-21 108.6 Clostridia Bacteria 1VP5Y@1239,25DSY@186801,COG1569@1,COG1569@2 NA|NA|NA S toxin-antitoxin system, toxin component, PIN family MAG.T1.179_02724 479431.Namu_4513 7.1e-21 106.3 Bacteria ofn32 ko:K07746 ko00000,ko02048 Bacteria COG2002@1,COG2002@2 NA|NA|NA K toxin-antitoxin pair type II binding MAG.T1.179_02725 1449355.JQNR01000003_gene273 2.7e-55 222.2 Actinobacteria yvaK 3.1.1.1 ko:K03928 ko00000,ko01000 Bacteria 2GM1Y@201174,COG1647@1,COG1647@2 NA|NA|NA S Esterase MAG.T1.179_02726 55952.BU52_09430 6.2e-22 110.5 Actinobacteria Bacteria 2E49S@1,2I83P@201174,32RRE@2 NA|NA|NA S Protein of unknown function (DUF3040) MAG.T1.179_02727 1172188.KB911827_gene4382 3e-136 491.9 Intrasporangiaceae dinB 2.7.7.7 ko:K02346 ko00000,ko01000,ko03400 Bacteria 2GKBI@201174,4FE61@85021,COG0389@1,COG0389@2 NA|NA|NA L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII MAG.T1.179_02728 1121017.AUFG01000001_gene3000 0.0 1368.2 Intrasporangiaceae dnaE2 2.7.7.7 ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 2GJ1P@201174,4FEK0@85021,COG0587@1,COG0587@2 NA|NA|NA L Belongs to the DNA polymerase type-C family. DnaE2 subfamily MAG.T1.179_02729 1380356.JNIK01000021_gene4429 6.4e-27 127.1 Frankiales Bacteria 2CGM3@1,2GP7H@201174,32S47@2,4ET5Q@85013 NA|NA|NA MAG.T1.179_02730 1123320.KB889675_gene3873 1.9e-20 105.1 Actinobacteria Bacteria 2ERD0@1,2GVR1@201174,33IYN@2 NA|NA|NA MAG.T1.179_02731 1146883.BLASA_0920 3e-69 268.5 Frankiales crtA 1.14.15.9 ko:K09847 ko00906,ko01100,map00906,map01100 R07525,R07526,R07537,R07538 RC02084 ko00000,ko00001,ko01000 Bacteria 29UQ5@1,2II02@201174,30G1W@2,4EV3Q@85013 NA|NA|NA C spheroidene monooxygenase MAG.T1.179_02733 1048339.KB913029_gene4359 3.9e-49 201.8 Frankiales 5.5.1.19 ko:K22502 ko00906,map00906 R03824,R05341 RC01004 ko00000,ko00001,ko01000 Bacteria 2IIUJ@201174,4EVC1@85013,COG2324@1,COG2324@2 NA|NA|NA S Carotenoid biosynthesis protein MAG.T1.179_02734 266940.Krad_3224 2.5e-92 345.9 Actinobacteria ko:K14597 ko00906,map00906 R07544,R07546 RC00262 ko00000,ko00001 Bacteria 2GJZI@201174,COG1215@1,COG1215@2 NA|NA|NA M Glycosyl transferase, family 2 MAG.T1.179_02735 1380356.JNIK01000013_gene4257 1.7e-170 605.9 Frankiales crtD 1.3.99.26,1.3.99.27,1.3.99.28,1.3.99.29,1.3.99.31,5.4.99.9 ko:K01854,ko:K09845,ko:K10027 ko00052,ko00520,ko00906,ko01100,ko01110,map00052,map00520,map00906,map01100,map01110 R00505,R04787,R04798,R04800,R07517,R07520,R07523,R07534,R09009,R09691,R09692 RC00317,RC01214,RC02080,RC02088,RC02396,RC02605 ko00000,ko00001,ko01000 Bacteria 2GJAV@201174,4ETTQ@85013,COG1233@1,COG1233@2 NA|NA|NA Q Flavin containing amine oxidoreductase MAG.T1.179_02736 1246995.AFR_10060 1.1e-119 437.2 Micromonosporales cvrA ko:K11105 ko00000,ko02000 2.A.36.6 Bacteria 2GJ9B@201174,4D9E3@85008,COG3263@1,COG3263@2 NA|NA|NA P Sodium/hydrogen exchanger family MAG.T1.179_02737 326424.FRAAL2165 6.4e-42 177.6 Frankiales 2.7.8.5 ko:K00995 ko00564,ko01100,map00564,map01100 R01801 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 Bacteria 2IDSP@201174,4ET6D@85013,COG0558@1,COG0558@2 NA|NA|NA I CDP-alcohol phosphatidyltransferase MAG.T1.179_02738 1380347.JNII01000005_gene3165 8.8e-25 120.6 Frankiales ko:K09807 ko00000 Bacteria 2GM1U@201174,4ET95@85013,COG2968@1,COG2968@2 NA|NA|NA S Protein of unknown function (DUF541) MAG.T1.179_02739 1048339.KB913029_gene4363 5.3e-100 370.9 Frankiales metF GO:0003674,GO:0003824,GO:0004489,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJTN@201174,4ERKZ@85013,COG0685@1,COG0685@2 NA|NA|NA E Methylenetetrahydrofolate reductase MAG.T1.179_02740 1123320.KB889698_gene9326 7.5e-99 367.1 Actinobacteria hbd 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 Bacteria 2GJBM@201174,COG1250@1,COG1250@2 NA|NA|NA I 3-hydroxyacyl-CoA dehydrogenase MAG.T1.179_02741 981369.JQMJ01000004_gene5811 8.5e-55 219.9 Streptacidiphilus murA GO:0008150,GO:0040007 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 R00660 RC00350 ko00000,ko00001,ko01000,ko01011 Bacteria 2GJPW@201174,2NEK0@228398,COG0766@1,COG0766@2 NA|NA|NA M EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) MAG.T1.179_02743 585531.HMPREF0063_12237 1.1e-66 259.6 Propionibacteriales yvqK 2.5.1.17 ko:K00798 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 Bacteria 2GMHN@201174,4DNZ5@85009,COG2096@1,COG2096@2 NA|NA|NA S Cobalamin adenosyltransferase MAG.T1.179_02744 1268303.RHODMAR_0120 1e-75 290.4 Nocardiaceae Bacteria 2GP1D@201174,4G9DV@85025,COG1215@1,COG1215@2 NA|NA|NA M Glycosyltransferase like family 2 MAG.T1.179_02745 543632.JOJL01000008_gene5609 9.1e-85 320.5 Micromonosporales exoM Bacteria 2GKTW@201174,4DIHT@85008,COG1216@1,COG1216@2 NA|NA|NA S Glycosyltransferase like family 2 MAG.T1.179_02746 58344.JOEL01000006_gene4701 1.2e-56 228.0 Actinobacteria Bacteria 2GMYJ@201174,COG2244@1,COG2244@2 NA|NA|NA G outer membrane autotransporter barrel domain protein MAG.T1.179_02749 526225.Gobs_0437 7.3e-45 188.3 Frankiales Bacteria 2GMYJ@201174,4EVNC@85013,COG2244@1,COG2244@2 NA|NA|NA S polysaccharide biosynthetic process MAG.T1.179_02750 797302.Halru_2865 9.3e-10 71.6 Halobacteria Archaea 23U89@183963,2XUFQ@28890,COG3919@1,arCOG06897@2157 NA|NA|NA S COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ) MAG.T1.179_02751 1089544.KB912942_gene1730 5.9e-78 298.1 Pseudonocardiales Bacteria 2I92N@201174,4DXBA@85010,COG3664@1,COG3664@2 NA|NA|NA G PFAM glycoside hydrolase family 39 MAG.T1.179_02752 1996.JOFO01000033_gene1260 3.2e-77 295.8 Actinobacteria Bacteria 2GKTW@201174,COG1216@1,COG1216@2 NA|NA|NA M Glycosyl transferase family 2 MAG.T1.179_02753 1144275.COCOR_04546 3.2e-61 242.7 Bacteria Bacteria COG2273@1,COG2273@2 NA|NA|NA G xyloglucan:xyloglucosyl transferase activity MAG.T1.179_02754 566461.SSFG_02307 1.1e-23 116.3 Actinobacteria atpC GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 Bacteria 2IHNZ@201174,COG0355@1,COG0355@2 NA|NA|NA C Produces ATP from ADP in the presence of a proton gradient across the membrane MAG.T1.179_02755 1504319.GM45_6105 8.5e-97 359.8 unclassified Actinobacteria (class) atpD GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 Bacteria 2GIY6@201174,3UW86@52018,COG0055@1,COG0055@2 NA|NA|NA C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits MAG.T1.179_02756 1116232.AHBF01000113_gene4604 8.7e-245 852.8 Actinobacteria pgm GO:0000271,GO:0003674,GO:0003824,GO:0004614,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0005996,GO:0006006,GO:0006012,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016052,GO:0016853,GO:0016866,GO:0016868,GO:0019318,GO:0019320,GO:0019388,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0055114,GO:0071704,GO:1901575,GO:1901576 5.4.2.2 ko:K01835 ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00549 R00959,R01057,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 iAPECO1_1312.APECO1_1376,iECED1_1282.ECED1_0670,iECNA114_1301.ECNA114_0627,iECOK1_1307.ECOK1_0699,iECP_1309.ECP_0709,iECS88_1305.ECS88_0725,iJN678.pgm,iLF82_1304.LF82_1632,iNRG857_1313.NRG857_03110,iUMN146_1321.UM146_14115,iYL1228.KPN_00711 Bacteria 2H1PI@201174,COG0033@1,COG0033@2 NA|NA|NA G Phosphoglucomutase MAG.T1.179_02757 1306174.JODP01000029_gene3831 3.3e-30 138.7 Actinobacteria ko:K03088 ko00000,ko03021 Bacteria 2IK5Q@201174,COG1595@1,COG1595@2 NA|NA|NA K belongs to the sigma-70 factor family, ECF subfamily MAG.T1.179_02758 66869.JNXG01000005_gene2143 1.3e-17 97.8 Streptomyces griseus group ko:K13582 ko04112,map04112 ko00000,ko00001 Bacteria 2GPMH@201174,417NJ@629295,COG3206@1,COG3206@2 NA|NA|NA M Domain of unknown function (DUF4349) MAG.T1.179_02759 1101188.KI912155_gene948 1.3e-42 179.1 Micrococcaceae 1.8.1.9 ko:K00384,ko:K03671 ko00450,ko04621,ko05418,map00450,map04621,map05418 R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000,ko03110 Bacteria 1W9G6@1268,2IKP1@201174,COG0526@1,COG0526@2 NA|NA|NA CO Belongs to the thioredoxin family MAG.T1.179_02760 1157637.KB892155_gene7597 2.1e-72 279.3 Actinobacteria speE 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 Bacteria 2GN8I@201174,COG0421@1,COG0421@2 NA|NA|NA E spermidine synthase MAG.T1.179_02761 266940.Krad_3968 1e-43 183.3 Actinobacteria Bacteria 2GRF0@201174,COG1514@1,COG1514@2 NA|NA|NA J 2'-5' RNA ligase MAG.T1.179_02762 1150864.MILUP08_40848 6.8e-123 447.2 Micromonosporales trpS GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 2GJ9A@201174,4DAKB@85008,COG0180@1,COG0180@2 NA|NA|NA J Tryptophanyl-tRNA synthetase MAG.T1.179_02763 1122138.AQUZ01000084_gene8782 3.9e-126 458.4 Propionibacteriales ytfL GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03699 ko00000,ko02042 Bacteria 2GKN5@201174,4DPDV@85009,COG1253@1,COG1253@2 NA|NA|NA S Transporter associated domain MAG.T1.179_02764 367299.JOEE01000007_gene23 8.8e-73 280.4 Intrasporangiaceae exoA 3.1.11.2 ko:K01142 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 2GKIS@201174,4FEP7@85021,COG0708@1,COG0708@2 NA|NA|NA L exodeoxyribonuclease III MAG.T1.179_02765 28444.JODQ01000002_gene4308 2e-201 708.4 Streptosporangiales icd GO:0000287,GO:0003674,GO:0003824,GO:0004448,GO:0004450,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006102,GO:0008150,GO:0008152,GO:0008270,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0016999,GO:0017144,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044464,GO:0045333,GO:0046487,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:0072350 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2GM3D@201174,4EFHD@85012,COG0538@1,COG0538@2 NA|NA|NA C Isocitrate/isopropylmalate dehydrogenase MAG.T1.179_02767 1278073.MYSTI_01666 1.2e-64 253.8 Myxococcales sua5 GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 2.7.7.87 ko:K07566 R10463 RC00745 ko00000,ko01000,ko03009,ko03016 Bacteria 1MVPM@1224,2WP34@28221,2YV20@29,42T6S@68525,COG0009@1,COG0009@2 NA|NA|NA J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine MAG.T1.179_02768 743718.Isova_2350 6.6e-271 940.3 Promicromonosporaceae secA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030312,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 Bacteria 2GIRT@201174,4F3T1@85017,COG0653@1,COG0653@2 NA|NA|NA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane MAG.T1.179_02769 765912.Thimo_2058 1.1e-136 493.4 Chromatiales cls ko:K06131 ko00564,ko01100,map00564,map01100 R07390 RC00017 ko00000,ko00001,ko01000 Bacteria 1MWUW@1224,1RPQG@1236,1WXED@135613,COG1502@1,COG1502@2 NA|NA|NA I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol MAG.T1.179_02770 1996.JOFO01000043_gene6393 7.7e-23 114.8 Actinobacteria Bacteria 2GN14@201174,COG2267@1,COG2267@2 NA|NA|NA I Alpha/beta hydrolase family MAG.T1.179_02771 1155718.KB891896_gene2090 2.2e-157 562.0 Actinobacteria carA GO:0000050,GO:0003674,GO:0003824,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0032991,GO:0034641,GO:0034654,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01955,ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 iAPECO1_1312.APECO1_1950,iUTI89_1310.UTI89_C0036,iYO844.BSU15510,ic_1306.c0040 Bacteria 2GKFA@201174,COG0505@1,COG0505@2 NA|NA|NA F Belongs to the CarA family MAG.T1.179_02772 443255.SCLAV_0714 2.4e-29 135.6 Actinobacteria Bacteria 2GM9I@201174,COG0505@1,COG0505@2 NA|NA|NA EF Belongs to the CarA family MAG.T1.179_02773 1146883.BLASA_2361 8.6e-179 633.3 Frankiales pyrC GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ0T@201174,4ERCY@85013,COG0044@1,COG0044@2 NA|NA|NA F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily MAG.T1.179_02774 1123320.KB889665_gene1431 3.1e-138 498.0 Actinobacteria pyrB GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 ko:K00608,ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 iYO844.BSU15490 Bacteria 2GKNA@201174,COG0540@1,COG0540@2 NA|NA|NA F Belongs to the ATCase OTCase family MAG.T1.179_02775 1123320.KB889665_gene1430 7.1e-63 246.9 Actinobacteria pyrR GO:0003674,GO:0003700,GO:0003824,GO:0004845,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006220,GO:0006221,GO:0006355,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0031323,GO:0031326,GO:0034641,GO:0034654,GO:0043094,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046390,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0055086,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0080090,GO:0090407,GO:0140110,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141 2.4.2.9 ko:K02825 ko00240,ko01100,map00240,map01100 R00966 RC00063 ko00000,ko00001,ko01000,ko03000 iHN637.CLJU_RS05275 Bacteria 2GJNP@201174,COG2065@1,COG2065@2 NA|NA|NA F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant MAG.T1.179_02776 1449353.JQMQ01000005_gene847 8.2e-66 256.5 Streptacidiphilus bldD ko:K07110,ko:K21572 ko00000,ko02000,ko03000 8.A.46.1,8.A.46.3 Bacteria 2GVFR@201174,2NEHZ@228398,COG1395@1,COG1395@2 NA|NA|NA K Helix-turn-helix MAG.T1.179_02777 67315.JOBD01000013_gene7146 9.3e-166 590.1 Actinobacteria pyk GO:0003674,GO:0003824,GO:0004743,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016043,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042802,GO:0042866,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 e_coli_core.b1854,iAF1260.b1854,iB21_1397.B21_01813,iBWG_1329.BWG_1668,iEC042_1314.EC042_2021,iECBD_1354.ECBD_1784,iECB_1328.ECB_01825,iECDH10B_1368.ECDH10B_1995,iECDH1ME8569_1439.ECDH1ME8569_1801,iECD_1391.ECD_01825,iECO103_1326.ECO103_2044,iECO111_1330.ECO111_2362,iECO26_1355.ECO26_2692,iECUMN_1333.ECUMN_2152,iETEC_1333.ETEC_1887,iEcDH1_1363.EcDH1_1786,iEcE24377_1341.EcE24377A_2084,iEcHS_1320.EcHS_A1947,iEcSMS35_1347.EcSMS35_1332,iEcolC_1368.EcolC_1778,iG2583_1286.G2583_2306,iJO1366.b1854,iJR904.b1854,iSBO_1134.SBO_1162,iSSON_1240.SSON_1294,iSbBS512_1146.SbBS512_E2130,iUMNK88_1353.UMNK88_2326,iY75_1357.Y75_RS09740 Bacteria 2GJY8@201174,COG0469@1,COG0469@2 NA|NA|NA G Belongs to the pyruvate kinase family MAG.T1.179_02779 134676.ACPL_3028 1.3e-104 386.7 Micromonosporales ftsH2 ko:K03798,ko:K13525 ko04141,ko05134,map04141,map05134 M00400,M00403,M00742 ko00000,ko00001,ko00002,ko01000,ko01002,ko03019,ko03110,ko04131,ko04147 3.A.16.1 Bacteria 2I2U8@201174,4DBYF@85008,COG0465@1,COG0465@2 NA|NA|NA O Holliday junction DNA helicase ruvB N-terminus MAG.T1.179_02780 405948.SACE_3997 9.2e-214 749.6 Pseudonocardiales gltD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 iJN678.gltD,iNJ661.Rv3858c,iSB619.SA_RS02450 Bacteria 2GJ0A@201174,4DYTC@85010,COG0493@1,COG0493@2 NA|NA|NA E NADH NADPH, small subunit MAG.T1.179_02781 1048339.KB913029_gene4530 1.7e-254 885.2 Frankiales gltB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 Bacteria 2GN09@201174,4ERS2@85013,COG0067@1,COG0067@2,COG0069@1,COG0069@2 NA|NA|NA E Glutamate synthase MAG.T1.179_02783 1078020.KEK_03787 6.7e-23 114.8 Mycobacteriaceae Bacteria 233RT@1762,2IAWJ@201174,COG2345@1,COG2345@2 NA|NA|NA K Transcriptional regulator MAG.T1.179_02784 751945.Theos_1037 1.6e-170 605.9 Deinococcus-Thermus ko:K02575 ko00910,map00910 M00615 ko00000,ko00001,ko00002,ko02000 2.A.1.8 Bacteria 1WJJV@1297,COG2223@1,COG2223@2 NA|NA|NA P Major Facilitator Superfamily MAG.T1.179_02785 1123386.AUIW01000006_gene1638 2.4e-147 528.9 Deinococcus-Thermus narK ko:K02575 ko00910,map00910 M00615 ko00000,ko00001,ko00002,ko02000 2.A.1.8 Bacteria 1WJ7D@1297,COG2223@1,COG2223@2 NA|NA|NA P Major Facilitator Superfamily MAG.T1.179_02786 390989.JOEG01000004_gene3799 4e-82 312.0 Micromonosporales mog 2.10.1.1,2.8.1.12,4.6.1.17 ko:K03635,ko:K03637,ko:K03750 ko00790,ko01100,ko04122,map00790,map01100,map04122 R09395,R09735,R11372 RC02507,RC03425,RC03462 ko00000,ko00001,ko01000 Bacteria 2GP1B@201174,4DBSX@85008,COG0303@1,COG0303@2,COG0521@1,COG0521@2 NA|NA|NA H Probable molybdopterin binding domain MAG.T1.179_02787 66373.JOFQ01000008_gene441 9e-42 177.6 Actinobacteria mobA 2.7.7.77 ko:K03752 ko00790,ko01100,map00790,map01100 R11581 ko00000,ko00001,ko01000 Bacteria 2GJVE@201174,COG0746@1,COG0746@2 NA|NA|NA H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor MAG.T1.179_02788 1380393.JHVP01000002_gene1835 1.7e-44 185.7 Frankiales moaC 4.6.1.17 ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 R11372 RC03425 ko00000,ko00001,ko01000 Bacteria 2IHR6@201174,4ESM0@85013,COG0315@1,COG0315@2 NA|NA|NA H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) MAG.T1.179_02789 208444.JNYY01000006_gene6922 1e-67 263.8 Pseudonocardiales moaE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.7.7.80,2.8.1.11,2.8.1.12,4.6.1.17 ko:K03635,ko:K03637,ko:K21147 ko00790,ko01100,ko04122,map00790,map01100,map04122 R07459,R07461,R09395,R11372 RC00043,RC02507,RC03425 ko00000,ko00001,ko01000 Bacteria 2II28@201174,4DZNU@85010,COG0314@1,COG0314@2,COG0521@1,COG0521@2 NA|NA|NA H TIGRFAM molybdenum cofactor synthesis MAG.T1.179_02790 1120936.KB907219_gene3177 2.8e-117 428.7 Streptosporangiales moaA GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0030312,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0071944,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.22,4.6.1.17 ko:K03639,ko:K20967 ko00790,ko01100,ko04122,map00790,map01100,map04122 R09394,R11372 RC03420,RC03425 ko00000,ko00001,ko01000 Bacteria 2GN0V@201174,4EGC1@85012,COG2896@1,COG2896@2 NA|NA|NA H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate MAG.T1.179_02791 1121952.ATXT01000015_gene350 3.3e-08 64.3 Microbacteriaceae moaD 2.8.1.12 ko:K03636,ko:K21142 ko00790,ko01100,ko04122,map00790,map01100,map04122 R09395 RC02507 ko00000,ko00001,ko01000 Bacteria 2HSWM@201174,4FQNM@85023,COG1977@1,COG1977@2 NA|NA|NA H ThiS family MAG.T1.179_02792 478801.Ksed_19270 2e-81 309.7 Actinobacteria ko:K03321 ko00000,ko02000 2.A.53.3 Bacteria 2H1V9@201174,COG0659@1,COG0659@2 NA|NA|NA P Molybdate transporter of MFS superfamily MAG.T1.179_02794 357809.Cphy_2216 2.1e-22 113.2 Lachnoclostridium ko:K07452,ko:K09384 ko00000,ko01000,ko02048 Bacteria 1U8TV@1239,223CF@1506553,258B5@186801,COG0470@1,COG0470@2 NA|NA|NA L DNA polymerase III MAG.T1.179_02796 1283283.ATXA01000001_gene544 1e-34 153.3 Frankiales Bacteria 2IN6K@201174,4ETDQ@85013,COG1714@1,COG1714@2 NA|NA|NA S RDD family MAG.T1.179_02797 471852.Tcur_2987 1.8e-117 429.5 Streptosporangiales 1.11.1.19 ko:K15733 ko00000,ko01000 Bacteria 2GIUB@201174,4EICS@85012,COG2837@1,COG2837@2 NA|NA|NA P Dyp-type peroxidase family MAG.T1.179_02798 749414.SBI_01457 4.3e-37 161.8 Actinobacteria ycgQ ko:K08986 ko00000 Bacteria 2GZEU@201174,COG3689@1,COG3689@2 NA|NA|NA S TIGRFAM TIGR03943 family protein MAG.T1.179_02799 1463881.KL591026_gene2615 3.9e-63 248.1 Actinobacteria ycgR ko:K07089 ko00000 Bacteria 2GJQ0@201174,COG0701@1,COG0701@2 NA|NA|NA P permease MAG.T1.179_02800 1463887.KL589971_gene4547 2.5e-15 88.2 Actinobacteria ycgR ko:K07089 ko00000 Bacteria 2GJQ0@201174,COG0701@1,COG0701@2 NA|NA|NA P permease MAG.T1.179_02801 350058.Mvan_3810 5.8e-310 1070.1 Mycobacteriaceae pacL2 3.6.3.8 ko:K01537 ko00000,ko01000 3.A.3.2 Bacteria 232MQ@1762,2GJJC@201174,COG0474@1,COG0474@2 NA|NA|NA P ATPase, P-type (transporting), HAD superfamily, subfamily IC MAG.T1.179_02803 1184609.KILIM_066_00310 1.6e-81 308.9 Dermatophilaceae Bacteria 2GY1D@201174,4F7U4@85018,COG0454@1,COG0456@2 NA|NA|NA K Acetyltransferase (GNAT) family MAG.T1.179_02804 196162.Noca_1250 2.9e-18 98.2 Propionibacteriales pccA 2.1.3.1,6.4.1.3 ko:K01965,ko:K17490 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R00353,R01859 RC00040,RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 Bacteria 2GPU3@201174,4DVQ9@85009,COG4770@1,COG4770@2 NA|NA|NA I Biotin-lipoyl like MAG.T1.179_02805 196162.Noca_1249 3.6e-15 87.4 Propionibacteriales 2.1.3.1 ko:K17489 ko00640,map00640 R00353 RC00040 ko00000,ko00001,ko01000 Bacteria 2EJZC@1,2GYHI@201174,33DPX@2,4DW75@85009 NA|NA|NA MAG.T1.179_02806 196162.Noca_1248 1.1e-236 825.9 Propionibacteriales mmdA 2.1.3.1,2.1.3.15,6.4.1.2,6.4.1.3,6.4.1.4 ko:K01966,ko:K01969,ko:K17489,ko:K18472 ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212 M00036,M00082,M00373,M00741 R00353,R00742,R01859,R04138,R04386 RC00040,RC00097,RC00253,RC00367,RC00609,RC00942 ko00000,ko00001,ko00002,ko01000 iLJ478.TM0716 Bacteria 2GIRU@201174,4DU79@85009,COG4799@1,COG4799@2 NA|NA|NA I Malonate decarboxylase gamma subunit (MdcE) MAG.T1.179_02807 196162.Noca_1247 3e-54 218.0 Propionibacteriales oadA 2.1.3.1,4.1.1.3,6.4.1.1 ko:K01571,ko:K01960,ko:K03416 ko00020,ko00620,ko00640,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00640,map00720,map01100,map01120,map01200,map01230 M00173,M00620 R00217,R00344,R00353,R00930 RC00040,RC00097,RC00367 ko00000,ko00001,ko00002,ko01000,ko02000 3.B.1.1.1 iLJ478.TM0128 Bacteria 2IASR@201174,4DWP1@85009,COG5016@1,COG5016@2 NA|NA|NA C Conserved carboxylase domain MAG.T1.179_02810 365528.KB891102_gene4508 4.3e-07 60.8 Actinobacteria Bacteria 28XC6@1,2GY17@201174,2ZJA2@2 NA|NA|NA MAG.T1.179_02812 1121934.AUDX01000004_gene2657 4.8e-36 157.9 Microbacteriaceae Bacteria 2GX8K@201174,4FQPR@85023,COG1309@1,COG1309@2 NA|NA|NA K Bacterial regulatory proteins, tetR family MAG.T1.179_02813 1003195.SCAT_5254 3.5e-107 395.6 Actinobacteria Bacteria 2GIV9@201174,COG0642@1,COG2205@2 NA|NA|NA T PhoQ Sensor MAG.T1.179_02814 1048339.KB913029_gene2698 4.1e-93 347.8 Frankiales Bacteria 2GIZB@201174,4ERW3@85013,COG0745@1,COG0745@2 NA|NA|NA T response regulator MAG.T1.179_02815 235985.BBPN01000004_gene3111 5.5e-16 89.7 Streptacidiphilus ko:K05337 ko00000 Bacteria 2GSJ7@201174,2NJW1@228398,COG1141@1,COG1141@2 NA|NA|NA C 4Fe-4S single cluster domain MAG.T1.179_02816 436229.JOEH01000022_gene682 5.9e-111 407.9 Streptacidiphilus nuoF2 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2GNN9@201174,2NGPM@228398,COG1894@1,COG1894@2 NA|NA|NA C NADH-ubiquinone oxidoreductase-F iron-sulfur binding region MAG.T1.179_02817 106370.Francci3_2586 1e-42 180.3 Frankiales ko:K17247 ko00000 Bacteria 2GQH2@201174,4EW08@85013,COG4097@1,COG4097@2 NA|NA|NA P PFAM Ferric reductase domain protein transmembrane component domain MAG.T1.179_02818 105422.BBPM01000049_gene1445 1.2e-68 266.9 Streptacidiphilus apbE 2.7.1.180 ko:K03734 ko00000,ko01000 Bacteria 2H74Y@201174,2NGV9@228398,COG1477@1,COG1477@2 NA|NA|NA H ApbE family MAG.T1.179_02820 382245.ASA_0486 9e-51 206.8 Aeromonadales maa 2.3.1.79 ko:K00661 ko00000,ko01000 Bacteria 1RA2T@1224,1S3ZZ@1236,1Y4GY@135624,COG0110@1,COG0110@2 NA|NA|NA S Maltose acetyltransferase MAG.T1.179_02823 263358.VAB18032_21750 1.9e-25 123.6 Actinobacteria Bacteria 2GRFR@201174,COG3409@1,COG3409@2 NA|NA|NA M PFAM Peptidoglycan-binding domain 1 protein MAG.T1.179_02824 196162.Noca_0300 1.6e-31 142.1 Propionibacteriales Bacteria 2IKJX@201174,32SQA@2,4DR6N@85009,COG5450@1 NA|NA|NA K Transcription regulator of the Arc MetJ class MAG.T1.179_02825 1172185.KB911513_gene4762 4.7e-48 197.6 Nocardiaceae ko:K21429 ko00000,ko01002 Bacteria 2GKWI@201174,4G7P5@85025,COG4894@1,COG4894@2 NA|NA|NA S LURP-one-related MAG.T1.179_02826 1429046.RR21198_1564 1.7e-24 118.2 Nocardiaceae Bacteria 2BGV5@1,2HM66@201174,32AUV@2,4G51E@85025 NA|NA|NA MAG.T1.179_02829 522306.CAP2UW1_2420 6.2e-25 122.5 Bacteria Bacteria COG1674@1,COG1674@2 NA|NA|NA D ftsk spoiiie MAG.T1.179_02832 1193181.BN10_1070030 6.3e-225 786.9 Intrasporangiaceae acd 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 Bacteria 2GJIB@201174,4FEU0@85021,COG1960@1,COG1960@2 NA|NA|NA I Butyryl-CoA dehydrogenase MAG.T1.179_02833 1323361.JPOC01000066_gene82 2e-79 303.1 Nocardiaceae ko:K06889 ko00000 Bacteria 2IA0F@201174,4FUH3@85025,COG1073@1,COG1073@2 NA|NA|NA S BAAT / Acyl-CoA thioester hydrolase C terminal MAG.T1.179_02834 1123024.AUII01000008_gene1780 2.8e-36 158.7 Pseudonocardiales Bacteria 2IIA5@201174,4E6CS@85010,COG0640@1,COG0640@2 NA|NA|NA K Helix-turn-helix domain MAG.T1.179_02836 196162.Noca_4242 8.3e-119 433.7 Propionibacteriales ko:K06994 ko00000 Bacteria 2GJ5A@201174,4DNDC@85009,COG2409@1,COG2409@2 NA|NA|NA P MMPL family MAG.T1.179_02837 1101188.KI912157_gene87 2.8e-19 101.7 Actinobacteria Bacteria 2EKKY@1,2I2JI@201174,33EAR@2 NA|NA|NA MAG.T1.179_02839 1385518.N798_07465 3.5e-109 401.4 Actinobacteria Bacteria 28JU1@1,2IC3T@201174,2Z9J4@2 NA|NA|NA MAG.T1.179_02840 408672.NBCG_01336 1.8e-40 172.2 Propionibacteriales rnhA GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 ko:K03469 ko03030,map03030 ko00000,ko00001,ko01000,ko03032 Bacteria 2GK53@201174,4DQHV@85009,COG0328@1,COG0328@2,COG0454@1,COG0456@2 NA|NA|NA L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids MAG.T1.179_02841 1146883.BLASA_2357 2.8e-83 315.5 Actinobacteria ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GN8P@201174,COG1131@1,COG1131@2 NA|NA|NA V ABC transporter MAG.T1.179_02842 1211815.CBYP010000005_gene232 1.4e-17 97.4 Actinobacteria Bacteria 2GVAC@201174,COG1277@1,COG1277@2 NA|NA|NA S ABC-type transport system involved in multi-copper enzyme maturation permease component MAG.T1.179_02843 356851.JOAN01000021_gene2322 1.5e-29 137.1 Micromonosporales Bacteria 2GMDB@201174,4DAZM@85008,COG1670@1,COG1670@2 NA|NA|NA J Acetyltransferase (GNAT) domain MAG.T1.179_02846 710696.Intca_0346 1.4e-214 752.3 Actinobacteria nagC ko:K02003,ko:K02565,ko:K15545 M00258 ko00000,ko00002,ko02000,ko03000 3.A.1 Bacteria 2ICG2@201174,COG1321@1,COG1321@2 NA|NA|NA K iron dependent repressor MAG.T1.179_02848 365528.KB891239_gene6028 2.9e-75 289.3 Frankiales ko:K14059 ko00000 Bacteria 2GMMI@201174,4ESQP@85013,COG0582@1,COG0582@2 NA|NA|NA L Belongs to the 'phage' integrase family MAG.T1.179_02851 337191.KTR9_4794 6.8e-61 241.1 Actinobacteria ko:K03496 ko00000,ko03036,ko04812 Bacteria 2IHZI@201174,COG1192@1,COG1192@2 NA|NA|NA D PFAM Cobyrinic acid a,c-diamide synthase MAG.T1.179_02854 196162.Noca_4737 2.4e-64 253.8 Bacteria Bacteria 2EWQ2@1,33Q1X@2 NA|NA|NA MAG.T1.179_02856 710696.Intca_3502 1.6e-31 141.7 Intrasporangiaceae 2.3.1.15 ko:K08591,ko:K19159 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004,ko02048 Bacteria 2GRC8@201174,4FJ8S@85021,COG2161@1,COG2161@2 NA|NA|NA D Antitoxin component of a toxin-antitoxin (TA) module MAG.T1.179_02857 710696.Intca_3501 4.3e-32 143.7 Intrasporangiaceae ko:K06218 ko00000,ko02048 Bacteria 2GRQR@201174,4FJ7R@85021,COG2026@1,COG2026@2 NA|NA|NA DJ ParE toxin of type II toxin-antitoxin system, parDE MAG.T1.179_02858 1048339.KB913029_gene158 2.2e-28 133.3 Frankiales Bacteria 2IHBR@201174,4EW9H@85013,COG0741@1,COG0741@2,COG3103@1,COG4991@2 NA|NA|NA MT Transglycosylase SLT domain MAG.T1.179_02859 1449976.KALB_374 2.8e-09 68.9 Pseudonocardiales Bacteria 2IFSD@201174,4E6ND@85010,COG1476@1,COG1476@2 NA|NA|NA K transcriptional regulators MAG.T1.179_02860 1101188.KI912157_gene288 6.2e-14 83.6 Actinobacteria Bacteria 2BH0A@1,2GUIE@201174,32B0E@2 NA|NA|NA MAG.T1.179_02864 298655.KI912266_gene338 1.4e-39 169.1 Frankiales rplL GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 ko:K02935 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IKNW@201174,4ESPE@85013,COG0222@1,COG0222@2 NA|NA|NA J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation MAG.T1.179_02865 367299.JOEE01000001_gene2148 1.4e-60 239.6 Intrasporangiaceae rplJ GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0017148,GO:0019222,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 ko:K02864,ko:K02935 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GM0V@201174,4FEG8@85021,COG0244@1,COG0244@2 NA|NA|NA J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors MAG.T1.179_02866 1089455.MOPEL_098_00060 1e-101 376.3 Dermatophilaceae rplA GO:0000027,GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006417,GO:0006446,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0017148,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045947,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 ko:K02863 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GM51@201174,4F6JF@85018,COG0081@1,COG0081@2 NA|NA|NA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release MAG.T1.179_02867 1155718.KB891885_gene6434 1.3e-62 245.7 Actinobacteria rplK GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010467,GO:0015934,GO:0015968,GO:0016043,GO:0019538,GO:0019843,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0032984,GO:0032991,GO:0033554,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0042594,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0051716,GO:0065003,GO:0070925,GO:0071496,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02867 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IFCK@201174,COG0080@1,COG0080@2 NA|NA|NA J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors MAG.T1.179_02868 1123320.KB889574_gene5588 1.7e-71 276.2 Actinobacteria nusG GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0030312,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 ko:K02601 ko00000,ko03009,ko03021 Bacteria 2GJFW@201174,COG0250@1,COG0250@2 NA|NA|NA K Participates in transcription elongation, termination and antitermination MAG.T1.179_02869 390989.JOEG01000009_gene1179 1.1e-10 72.4 Micromonosporales secE GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K03073 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 Bacteria 2GQFP@201174,4DF5J@85008,COG0690@1,COG0690@2 NA|NA|NA U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation MAG.T1.179_02871 105420.BBPO01000022_gene5822 7e-183 646.7 Streptacidiphilus aspC Bacteria 2GJ7R@201174,2NHQV@228398,COG0436@1,COG0436@2 NA|NA|NA E Cys/Met metabolism PLP-dependent enzyme MAG.T1.179_02872 196162.Noca_0672 7.9e-103 380.6 Propionibacteriales murB GO:0000166,GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008360,GO:0008762,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0022603,GO:0022604,GO:0030203,GO:0034645,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045229,GO:0048037,GO:0050660,GO:0050662,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0055114,GO:0065007,GO:0065008,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 iECED1_1282.ECED1_4683,iECUMN_1333.ECUMN_4498_AT6,iLF82_1304.LF82_1416,iNRG857_1313.NRG857_19845 Bacteria 2GIV2@201174,4DNF7@85009,COG0812@1,COG0812@2 NA|NA|NA M Cell wall formation MAG.T1.179_02874 1304865.JAGF01000001_gene1598 1.2e-83 316.6 Actinobacteria fnt ko:K06212,ko:K21993 ko00000,ko02000 1.A.16.1.1,1.A.16.1.3,1.A.16.2 Bacteria 2I8DX@201174,COG2116@1,COG2116@2 NA|NA|NA P Formate nitrite transporter MAG.T1.179_02875 1463864.JOGO01000020_gene3435 3.3e-19 100.1 Actinobacteria rpmG ko:K02913 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GQFG@201174,COG0267@1,COG0267@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL33 family MAG.T1.179_02879 1068980.ARVW01000001_gene1643 4.9e-28 132.5 Pseudonocardiales Bacteria 2IC44@201174,4E4J8@85010,COG1357@1,COG1357@2 NA|NA|NA S PFAM Pentapeptide repeats (8 copies) MAG.T1.179_02882 110319.CF8_4272 1.1e-52 214.2 Actinobacteria coiA ko:K06198 ko00000 Bacteria 2IPIX@201174,COG4469@1,COG4469@2 NA|NA|NA S Competence protein MAG.T1.179_02883 196162.Noca_1086 1.3e-247 862.8 Propionibacteriales resA 3.1.21.5 ko:K01156 ko00000,ko01000,ko02048 Bacteria 2I8IG@201174,4DSXW@85009,COG1061@1,COG1061@2 NA|NA|NA KL Type III restriction enzyme, res subunit MAG.T1.179_02884 196162.Noca_1085 3.4e-172 611.7 Propionibacteriales modB 2.1.1.72 ko:K00571,ko:K07316 ko00000,ko01000,ko02048 Bacteria 2I8FH@201174,4DTYW@85009,COG2189@1,COG2189@2 NA|NA|NA L DNA methylase MAG.T1.179_02885 861360.AARI_08090 1.5e-45 189.5 Actinobacteria pin GO:0000150,GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140097,GO:1901360 Bacteria 2HSUX@201174,COG1961@1,COG1961@2 NA|NA|NA L Site-specific recombinases, DNA invertase Pin homologs MAG.T1.179_02887 1157943.KB892705_gene2163 1.6e-35 155.2 Mycobacteriaceae istB Bacteria 234SX@1762,2H714@201174,COG1484@1,COG1484@2 NA|NA|NA L IstB-like ATP binding protein MAG.T1.179_02888 656024.FsymDg_1517 1.2e-303 1048.9 Frankiales ko:K03727 ko00000,ko01000 Bacteria 2GJSV@201174,4ES27@85013,COG4581@1,COG4581@2 NA|NA|NA L DEAD DEAH box helicase MAG.T1.179_02889 67275.JOAP01000018_gene1118 3.7e-18 100.1 Actinobacteria Bacteria 2IBN6@201174,COG1502@1,COG1502@2 NA|NA|NA I PLD-like domain MAG.T1.179_02890 1122933.JNIY01000003_gene1068 5.2e-76 291.2 Cellulomonadaceae gluD ko:K02029,ko:K10007 ko02010,map02010 M00233,M00236 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.9 Bacteria 2GNBH@201174,4F29Z@85016,COG0765@1,COG0765@2 NA|NA|NA E Binding-protein-dependent transport system inner membrane component MAG.T1.179_02891 1122933.JNIY01000003_gene1069 3.3e-78 298.1 Cellulomonadaceae glnM GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015318,GO:0015711,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:1903825,GO:1905039 ko:K10006,ko:K10040 ko02010,map02010 M00228,M00233 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.9 Bacteria 2GNUR@201174,4F2G2@85016,COG0765@1,COG0765@2 NA|NA|NA P Binding-protein-dependent transport system inner membrane component MAG.T1.179_02892 1122933.JNIY01000003_gene1070 1.2e-117 429.5 Cellulomonadaceae gluB ko:K10005 ko02010,map02010 M00233 ko00000,ko00001,ko00002,ko02000 3.A.1.3.9 Bacteria 2GJH8@201174,4F1V2@85016,COG0834@1,COG0834@2 NA|NA|NA ET Bacterial periplasmic substrate-binding proteins MAG.T1.179_02893 935839.JAGJ01000007_gene3163 1.5e-106 392.5 Promicromonosporaceae gluA 3.6.3.21 ko:K02028,ko:K10008 ko02010,map02010 M00233,M00236 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3,3.A.1.3.9 Bacteria 2GIZW@201174,4F3U5@85017,COG1126@1,COG1126@2 NA|NA|NA E ATPases associated with a variety of cellular activities MAG.T1.179_02894 710696.Intca_0155 1.4e-60 239.6 Intrasporangiaceae 3.5.1.104 ko:K22278 ko00000,ko01000 Bacteria 2HEQK@201174,4FHJZ@85021,COG0726@1,COG0726@2 NA|NA|NA G Polysaccharide deacetylase MAG.T1.179_02895 1278308.KB907085_gene36 7.3e-11 73.6 Microbacteriaceae glxI 4.4.1.5 ko:K01759 ko00620,map00620 R02530 RC00004,RC00740 ko00000,ko00001,ko01000 Bacteria 2GVCV@201174,4FSM4@85023,COG0346@1,COG0346@2 NA|NA|NA E Glyoxalase-like domain MAG.T1.179_02897 1385520.N802_06110 2.7e-151 542.7 Actinobacteria degS Bacteria 2HDZV@201174,COG4585@1,COG4585@2 NA|NA|NA T Histidine kinase MAG.T1.179_02898 1385520.N802_06100 6.2e-34 150.6 Actinobacteria Bacteria 2E76N@1,2GRXJ@201174,338EF@2 NA|NA|NA MAG.T1.179_02899 1151122.AQYD01000005_gene2912 6.7e-157 560.8 Microbacteriaceae Bacteria 2GMJ4@201174,4FNB5@85023,COG2132@1,COG2132@2 NA|NA|NA Q Multicopper oxidase MAG.T1.179_02900 1027371.GOALK_026_00440 1.5e-57 229.6 Gordoniaceae Bacteria 2I51D@201174,4GF97@85026,COG3945@1,COG3945@2 NA|NA|NA S Hemerythrin HHE cation binding domain MAG.T1.179_02904 585529.HMPREF0291_11787 1.4e-24 119.8 Actinobacteria Bacteria 2DN7X@1,2IQJG@201174,32W0S@2 NA|NA|NA MAG.T1.179_02906 196162.Noca_1067 9.6e-91 340.5 Propionibacteriales modC 2.10.1.1,3.6.3.29,3.6.3.55 ko:K02017,ko:K02018,ko:K03750,ko:K15497 ko00790,ko01100,ko02010,map00790,map01100,map02010 M00189,M00423 R09735,R10531 RC00002,RC03462 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.6.5,3.A.1.8 Bacteria 2H2JF@201174,4DPFC@85009,COG3842@1,COG3842@2 NA|NA|NA P TOBE domain MAG.T1.179_02907 446471.Xcel_2809 8.4e-84 317.0 Promicromonosporaceae modB GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 3.6.3.29 ko:K02017,ko:K02018,ko:K15496 ko02010,map02010 M00189,M00423 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.6.5,3.A.1.8 iECO103_1326.ECO103_0752 Bacteria 2GJFB@201174,4F4A9@85017,COG4149@1,COG4149@2 NA|NA|NA P Binding-protein-dependent transport system inner membrane component MAG.T1.179_02909 1869.MB27_37345 3.5e-09 67.4 Micromonosporales moaD 2.8.1.12 ko:K03636,ko:K21142 ko00790,ko01100,ko04122,map00790,map01100,map04122 R09395 RC02507 ko00000,ko00001,ko01000 Bacteria 2IQIT@201174,4DFX3@85008,COG1977@1,COG1977@2 NA|NA|NA H ThiS family MAG.T1.179_02910 1193181.BN10_1080031 7.4e-117 427.2 Intrasporangiaceae moaA GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0030312,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0071944,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.22,4.6.1.17 ko:K03639,ko:K20967 ko00790,ko01100,ko04122,map00790,map01100,map04122 R09394,R11372 RC03420,RC03425 ko00000,ko00001,ko01000 Bacteria 2GN0V@201174,4FFGU@85021,COG2896@1,COG2896@2 NA|NA|NA H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate MAG.T1.179_02911 1120934.KB894410_gene6919 1.3e-67 263.5 Pseudonocardiales moaE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.7.7.80,2.8.1.11,2.8.1.12,4.6.1.17 ko:K03635,ko:K03637,ko:K21147 ko00790,ko01100,ko04122,map00790,map01100,map04122 R07459,R07461,R09395,R11372 RC00043,RC02507,RC03425 ko00000,ko00001,ko01000 Bacteria 2II28@201174,4DZNU@85010,COG0314@1,COG0314@2,COG0521@1,COG0521@2 NA|NA|NA H TIGRFAM molybdenum cofactor synthesis MAG.T1.179_02912 1121946.AUAX01000006_gene3402 1.9e-43 182.2 Micromonosporales moaC 4.6.1.17 ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 R11372 RC03425 ko00000,ko00001,ko01000 Bacteria 2IHR6@201174,4DDCJ@85008,COG0315@1,COG0315@2,COG0521@1,COG0521@2 NA|NA|NA H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) MAG.T1.179_02913 66875.JODY01000029_gene5271 2.4e-41 176.0 Actinobacteria mobA 2.7.7.77 ko:K03752 ko00790,ko01100,map00790,map01100 R11581 ko00000,ko00001,ko01000 Bacteria 2GJVE@201174,COG0746@1,COG0746@2 NA|NA|NA H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor MAG.T1.179_02917 253839.SSNG_07093 2.3e-10 72.0 Actinobacteria Bacteria 2ARFZ@1,2IFQT@201174,31GS5@2 NA|NA|NA MAG.T1.179_02918 543632.JOJL01000119_gene275 3e-113 414.8 Actinobacteria ko:K02450 M00331 ko00000,ko00002,ko02044 9.B.42 Bacteria 2IA4V@201174,COG3267@1,COG3267@2 NA|NA|NA U Type II secretory pathway component ExeA MAG.T1.179_02919 419947.MRA_2836 9.8e-139 500.4 Mycobacteriaceae ko:K07497 ko00000 Bacteria 236H8@1762,2I8NF@201174,COG2801@1,COG2801@2 NA|NA|NA L PFAM Integrase, catalytic MAG.T1.179_02920 419947.MRA_2835 6.2e-33 147.5 Mycobacteriaceae Bacteria 239RI@1762,2IGIB@201174,COG3677@1,COG3677@2 NA|NA|NA L Transposase MAG.T1.179_02922 55952.BU52_28445 5.2e-176 624.4 Actinobacteria Bacteria 2EW4U@1,2ICDK@201174,33PI0@2 NA|NA|NA MAG.T1.179_02923 653045.Strvi_8465 1.1e-189 669.5 Actinobacteria ko:K03733,ko:K04763 ko00000,ko03036 Bacteria 2GX0Z@201174,COG4974@1,COG4974@2 NA|NA|NA L 'Phage' integrase family MAG.T1.179_02924 100226.SCO4349 5.5e-186 657.5 Actinobacteria Bacteria 2CA8D@1,2I8TK@201174,2ZA16@2 NA|NA|NA MAG.T1.179_02925 653045.Strvi_2601 4.2e-271 940.6 Actinobacteria Bacteria 2GK5Z@201174,COG0582@1,COG0582@2 NA|NA|NA L Belongs to the 'phage' integrase family MAG.T1.179_02926 653045.Strvi_8468 4.9e-35 154.1 Actinobacteria Bacteria 2DWHI@1,2IKAK@201174,340CG@2 NA|NA|NA MAG.T1.179_02927 1283283.ATXA01000009_gene3212 9.6e-26 124.4 Actinobacteria Bacteria 2DRK0@1,2I7B6@201174,33C4R@2 NA|NA|NA MAG.T1.179_02929 1123237.Salmuc_04555 2.8e-39 168.7 Alphaproteobacteria Bacteria 1MXXT@1224,2U9WZ@28211,COG1961@1,COG1961@2 NA|NA|NA L Site-specific recombinases, DNA invertase Pin homologs MAG.T1.179_02930 479435.Kfla_2948 3.4e-31 141.0 Propionibacteriales Bacteria 2B34Q@1,2I2K1@201174,2ZK49@2,4DX2H@85009 NA|NA|NA MAG.T1.179_02931 443906.CMM_0908 2.2e-106 392.9 Microbacteriaceae 2.7.10.2 ko:K08253,ko:K16692 ko00000,ko01000,ko01001 Bacteria 2GJ1Y@201174,4FM6M@85023,COG0489@1,COG0489@2,COG3944@1,COG3944@2 NA|NA|NA D Chain length determinant protein MAG.T1.179_02932 1273125.Rrhod_2717 4.6e-66 259.2 Nocardiaceae pflA ko:K15539 ko00000 Bacteria 2GNIS@201174,4FVJA@85025,COG2976@1,COG2976@2 NA|NA|NA S Protein of unknown function (DUF4012) MAG.T1.179_02938 1894.JOER01000006_gene836 1.5e-10 73.2 Actinobacteria 3.1.3.12 ko:K01087 ko00500,ko01100,map00500,map01100 R02778 RC00017 ko00000,ko00001,ko01000 Bacteria 2IKKW@201174,COG1877@1,COG1877@2 NA|NA|NA G trehalose-phosphatase activity MAG.T1.179_02939 196162.Noca_2635 8.9e-57 226.9 Propionibacteriales Bacteria 2GJKM@201174,4DQZM@85009,COG2197@1,COG2197@2 NA|NA|NA T helix_turn_helix, Lux Regulon MAG.T1.179_02940 1172188.KB911825_gene3704 2.3e-72 279.6 Intrasporangiaceae Bacteria 2IAG1@201174,4FEJ3@85021,COG4585@1,COG4585@2 NA|NA|NA T Histidine kinase MAG.T1.179_02941 1298863.AUEP01000005_gene2350 8.5e-21 106.7 Propionibacteriales Bacteria 2CEFP@1,2GT06@201174,2ZGIZ@2,4DVNV@85009 NA|NA|NA MAG.T1.179_02942 1869.MB27_19770 2.2e-87 328.9 Micromonosporales ppgK 2.7.1.2,2.7.1.63,5.3.1.9 ko:K00845,ko:K00886,ko:K01810 ko00010,ko00030,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114,M00549 R00299,R01600,R01786,R02187,R02189,R02739,R02740,R03321 RC00002,RC00017,RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GJA0@201174,4DCFF@85008,COG1940@1,COG1940@2 NA|NA|NA GK ROK family MAG.T1.179_02943 1121926.AXWO01000013_gene2101 9e-55 220.7 Glycomycetales ytnM ko:K07090 ko00000 Bacteria 2GNPE@201174,4EZI4@85014,COG0730@1,COG0730@2 NA|NA|NA S Sulfite exporter TauE/SafE MAG.T1.179_02944 420662.Mpe_A3085 7.7e-23 112.8 unclassified Burkholderiales dbi 1.1.1.35 ko:K07516 ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212 M00087 R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000 Bacteria 1KM9E@119065,1MZPP@1224,2VUK0@28216,COG4281@1,COG4281@2 NA|NA|NA I acyl-coA-binding protein MAG.T1.179_02947 644548.SCNU_00065 1.8e-39 170.2 Gordoniaceae Bacteria 2GMMI@201174,4GD92@85026,COG0582@1,COG0582@2 NA|NA|NA L Belongs to the 'phage' integrase family MAG.T1.179_02948 227882.SAV_5 2.1e-19 103.2 Actinobacteria Bacteria 2ARC3@1,2IAHR@201174,31GN3@2 NA|NA|NA MAG.T1.179_02949 211114.JOEF01000046_gene5408 2.2e-109 402.1 Pseudonocardiales 2.1.1.72 ko:K03427 ko00000,ko01000,ko02048 Bacteria 2GKAQ@201174,4E4R9@85010,COG0286@1,COG0286@2 NA|NA|NA V PFAM N-6 DNA methylase MAG.T1.179_02950 861299.J421_2298 7.7e-46 191.4 Bacteria 3.1.21.3 ko:K01154 ko00000,ko01000,ko02048 Bacteria COG0732@1,COG0732@2 NA|NA|NA V type I restriction modification DNA specificity domain MAG.T1.179_02951 1111729.ATYV01000016_gene781 0.0 1272.7 Corynebacteriaceae hsdR 3.1.21.3 ko:K01153 ko00000,ko01000,ko02048 Bacteria 22JZQ@1653,2HI69@201174,COG0610@1,COG0610@2 NA|NA|NA L Subunit R is required for both nuclease and ATPase activities, but not for modification MAG.T1.179_02952 1146883.BLASA_0049 6.3e-29 134.8 Actinobacteria 2.7.11.1 ko:K07154 ko00000,ko01000,ko01001,ko02048 Bacteria 2IC2H@201174,COG3550@1,COG3550@2 NA|NA|NA S peptidyl-serine autophosphorylation MAG.T1.179_02953 1184607.AUCHE_18_00150 1.3e-28 133.7 Actinobacteria Bacteria 2DBHY@1,2IQRQ@201174,2Z9DM@2 NA|NA|NA MAG.T1.179_02954 933262.AXAM01000092_gene2926 5.2e-20 104.4 Deltaproteobacteria sppA ko:K04773 ko00000,ko01000,ko01002 Bacteria 1MY1I@1224,2WSJ6@28221,42PFB@68525,COG0616@1,COG0616@2 NA|NA|NA OU Serine dehydrogenase proteinase MAG.T1.179_02955 693661.Arcve_2129 1.4e-28 132.9 Euryarchaeota Archaea 2XU7H@28890,COG0616@1,arCOG01911@2157 NA|NA|NA O Serine dehydrogenase proteinase MAG.T1.179_02956 1217720.ALOX01000017_gene809 2.6e-38 164.5 Rhodospirillales dapA GO:0003674,GO:0003824,GO:0006082,GO:0006090,GO:0008150,GO:0008152,GO:0008840,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044281,GO:0071704 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUCM@1224,2JPJS@204441,2TR5W@28211,COG0329@1,COG0329@2 NA|NA|NA E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) MAG.T1.179_02957 1121382.JQKG01000029_gene2690 1.6e-41 176.4 Bacteria 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 Bacteria COG1091@1,COG1091@2 NA|NA|NA M dTDP-4-dehydrorhamnose reductase activity MAG.T1.179_02958 1095767.CAHD01000163_gene3000 5.2e-48 198.0 Actinobacteria Bacteria 2INQ3@201174,COG4122@1,COG4122@2 NA|NA|NA S Methyltransferase domain MAG.T1.179_02959 909613.UO65_4713 1.3e-33 150.6 Pseudonocardiales mprF ko:K07027 ko00000,ko02000 4.D.2 Bacteria 2IC25@201174,4E1XV@85010,COG0392@1,COG0392@2 NA|NA|NA S Lysylphosphatidylglycerol synthase TM region MAG.T1.179_02960 469383.Cwoe_3710 2.4e-85 322.4 Rubrobacteria Bacteria 2I2PK@201174,4CPE1@84995,COG1215@1,COG1215@2 NA|NA|NA M Glycosyl transferase family 2 MAG.T1.179_02961 1380354.JIAN01000006_gene1134 7.6e-118 431.4 Actinobacteria Bacteria 2IF8Q@201174,COG1287@1,COG1287@2 NA|NA|NA S oligosaccharyl transferase activity MAG.T1.179_02962 1304865.JAGF01000001_gene1494 2.3e-33 148.3 Actinobacteria Bacteria 2IKRD@201174,COG3795@1,COG3795@2 NA|NA|NA S PFAM YCII-related MAG.T1.179_02963 287986.DV20_29020 6.4e-23 113.6 Pseudonocardiales Bacteria 2IKRD@201174,4E51J@85010,COG3795@1,COG3795@2 NA|NA|NA S YCII-related domain MAG.T1.179_02964 477641.MODMU_1471 1.4e-125 456.4 Frankiales ko:K03088 ko00000,ko03021 Bacteria 2GJ36@201174,4ES50@85013,COG4941@1,COG4941@2 NA|NA|NA K TIGRFAM RNA polymerase sigma factor, sigma-70 family MAG.T1.179_02965 2045.KR76_15710 5.9e-07 60.1 Propionibacteriales ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GN8P@201174,4DP9K@85009,COG1131@1,COG1131@2 NA|NA|NA V AAA domain, putative AbiEii toxin, Type IV TA system MAG.T1.179_02966 1211815.CBYP010000005_gene232 6.5e-20 105.1 Actinobacteria Bacteria 2GVAC@201174,COG1277@1,COG1277@2 NA|NA|NA S ABC-type transport system involved in multi-copper enzyme maturation permease component MAG.T1.179_02967 1276920.ADIAG_02147 1.7e-26 125.2 Actinobacteria Bacteria 2GS7C@201174,COG4309@1,COG4309@2 NA|NA|NA S Uncharacterized conserved protein (DUF2249) MAG.T1.179_02968 754252.PFREUD_23710 3.5e-94 352.1 Actinobacteria eryK Bacteria 2IJFZ@201174,COG2124@1,COG2124@2 NA|NA|NA C Cytochrome P450 MAG.T1.179_02969 882083.SacmaDRAFT_4675 6.1e-44 184.5 Actinobacteria Bacteria 2IAWJ@201174,COG2345@1,COG2345@2 NA|NA|NA K Transcriptional regulator MAG.T1.179_02970 1385520.N802_11095 1.8e-92 345.5 Actinobacteria Bacteria 2AAWD@1,2IG0D@201174,3109H@2 NA|NA|NA S Alkylmercury lyase MAG.T1.179_02971 398513.BBNG_01119 2.4e-26 124.8 Bifidobacteriales Bacteria 2IHSV@201174,4D0ZF@85004,COG1917@1,COG1917@2 NA|NA|NA S Cupin 2, conserved barrel domain protein MAG.T1.179_02972 1429046.RR21198_1930 3e-88 331.6 Nocardiaceae narI GO:0001666,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006950,GO:0008150,GO:0008152,GO:0008940,GO:0009055,GO:0009061,GO:0009325,GO:0009628,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016661,GO:0019645,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0036293,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044799,GO:0045333,GO:0046906,GO:0048037,GO:0050896,GO:0055114,GO:0070469,GO:0070470,GO:0070482,GO:0071944,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901363,GO:1902494,GO:1990204 1.7.5.1 ko:K00370,ko:K00374,ko:K02575 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530,M00615,M00804 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 2.A.1.8,5.A.3.1 iEC042_1314.EC042_1594,iECABU_c1320.ECABU_c17020,iECUMN_1333.ECUMN_1718,iSF_1195.SF1230,ic_1306.c1897 Bacteria 2GJVI@201174,4FWVI@85025,COG2181@1,COG2181@2 NA|NA|NA C nitrate reductase, gamma subunit MAG.T1.179_02973 1127134.NOCYR_4275 3.1e-45 188.7 Nocardiaceae narJ GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016530,GO:0022607,GO:0034622,GO:0042126,GO:0042128,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0051131,GO:0065003,GO:0071704,GO:0071840,GO:0071941,GO:0140104,GO:2001057 ko:K00373,ko:K17052 ko02020,map02020 ko00000,ko00001,ko02000 5.A.3.8 iE2348C_1286.E2348C_1350,iECABU_c1320.ECABU_c15020,iECIAI1_1343.ECIAI1_1469,iECO103_1326.ECO103_1331,iECO111_1330.ECO111_1557,iECW_1372.ECW_m1594,iEKO11_1354.EKO11_2354,iLF82_1304.LF82_1462,iNRG857_1313.NRG857_06280,iSSON_1240.SSON_1659,iWFL_1372.ECW_m1594,iYO844.BSU37260,ic_1306.c1687 Bacteria 2IAQV@201174,4FWCV@85025,COG2180@1,COG2180@2 NA|NA|NA C Nitrate reductase MAG.T1.179_02974 1323361.JPOC01000040_gene4233 1.3e-80 306.2 Nocardiaceae narH 1.7.5.1 ko:K00371 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530,M00804 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000 5.A.3.1 Bacteria 2GJ8P@201174,4FUZU@85025,COG1140@1,COG1140@2 NA|NA|NA C Nitrate reductase beta subunit MAG.T1.179_02975 656024.FsymDg_0384 8.7e-54 218.8 Actinobacteria Bacteria 2GIV0@201174,COG0515@1,COG0515@2 NA|NA|NA KLT serine threonine protein kinase MAG.T1.179_02976 1304865.JAGF01000001_gene125 1.2e-133 483.4 Actinobacteria Bacteria 2IA73@201174,COG1085@1,COG1085@2 NA|NA|NA C uridylyltransferase MAG.T1.179_02977 153721.MYP_828 9.1e-50 204.9 Bacteria Bacteria 2EPPK@1,33HA5@2 NA|NA|NA MAG.T1.179_02978 1043205.AFYF01000026_gene433 1.2e-252 879.0 Intrasporangiaceae helZ 2.7.11.1 ko:K08282 ko00000,ko01000 Bacteria 2GISC@201174,4FFBR@85021,COG0553@1,COG0553@2,COG4715@1,COG4715@2 NA|NA|NA L SNF2 family N-terminal domain MAG.T1.179_02979 1123320.KB889688_gene406 8.1e-108 397.1 Actinobacteria sdhA GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0043436,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071704,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0072350,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 iE2348C_1286.E2348C_0603,iJN746.PP_4191,iPC815.YPO1111 Bacteria 2GJ45@201174,COG1053@1,COG1053@2 NA|NA|NA C succinate dehydrogenase MAG.T1.179_02980 1463936.JOJI01000013_gene4702 2.2e-110 405.2 Actinobacteria sdhB GO:0000104,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0022904,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045333,GO:0048037,GO:0051536,GO:0051537,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072350,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.3.5.1,1.3.5.4 ko:K00240 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 e_coli_core.b0724,iAF1260.b0724,iBWG_1329.BWG_0583,iEC042_1314.EC042_0742,iECDH10B_1368.ECDH10B_0791,iECDH1ME8569_1439.ECDH1ME8569_0683,iECUMN_1333.ECUMN_0802,iEcDH1_1363.EcDH1_2911,iJO1366.b0724,iJR904.b0724,iY75_1357.Y75_RS03765 Bacteria 2GP9C@201174,COG0479@1,COG0479@2 NA|NA|NA C Succinate dehydrogenase and fumarate reductase iron-sulfur protein MAG.T1.179_02981 1385518.N798_04965 2.3e-58 233.4 Intrasporangiaceae dac 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 ko00000,ko00001,ko01000,ko01002,ko01011 Bacteria 2GK3M@201174,4FFP2@85021,COG1686@1,COG1686@2 NA|NA|NA M Belongs to the peptidase S11 family MAG.T1.179_02982 446469.Sked_28590 1.7e-138 499.6 Actinobacteria fruA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090582 2.7.1.202,2.7.1.56 ko:K00882,ko:K02768,ko:K02769,ko:K02770,ko:K11202 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273,M00306 R02071,R03232 RC00002,RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1 iEcSMS35_1347.EcSMS35_2314,iJN746.PP_0795,iSbBS512_1146.SbBS512_E0796 Bacteria 2GJU4@201174,COG1299@1,COG1299@2,COG1445@1,COG1445@2 NA|NA|NA GT Phosphotransferase System MAG.T1.179_02983 1068978.AMETH_4863 6.2e-36 157.1 Pseudonocardiales fruA 2.7.1.202 ko:K02768,ko:K02769,ko:K02770,ko:K02806 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273 R03232 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1 Bacteria 2IMPP@201174,4E3T9@85010,COG1762@1,COG1762@2 NA|NA|NA G Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 MAG.T1.179_02984 287986.DV20_35975 1.6e-75 289.7 Pseudonocardiales fruK GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006000,GO:0006001,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008443,GO:0008662,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019318,GO:0019320,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046835,GO:0071704,GO:1901575 2.7.1.11,2.7.1.56 ko:K00882,ko:K16370 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00345 R00756,R02071,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 iAF1260.b2168,iAPECO1_1312.APECO1_4386,iB21_1397.B21_02056,iEC042_1314.EC042_2401,iEC55989_1330.EC55989_2421,iECABU_c1320.ECABU_c24990,iECBD_1354.ECBD_1490,iECB_1328.ECB_02097,iECDH10B_1368.ECDH10B_2325,iECDH1ME8569_1439.ECDH1ME8569_2104,iECD_1391.ECD_02097,iECED1_1282.ECED1_2616,iECH74115_1262.ECH74115_3304,iECIAI1_1343.ECIAI1_2248,iECIAI39_1322.ECIAI39_2308,iECNA114_1301.ECNA114_2259,iECO103_1326.ECO103_2643,iECO111_1330.ECO111_2886,iECO26_1355.ECO26_3080,iECOK1_1307.ECOK1_2400,iECP_1309.ECP_2208,iECS88_1305.ECS88_2316,iECSE_1348.ECSE_2436,iECSF_1327.ECSF_2049,iECSP_1301.ECSP_3046,iECUMN_1333.ECUMN_2504,iECW_1372.ECW_m2369,iECs_1301.ECs3060,iEKO11_1354.EKO11_1586,iETEC_1333.ETEC_2303,iEcDH1_1363.EcDH1_1490,iEcHS_1320.EcHS_A2305,iEcSMS35_1347.EcSMS35_2315,iEcolC_1368.EcolC_1480,iG2583_1286.G2583_2711,iJO1366.b2168,iJR904.b2168,iLF82_1304.LF82_0744,iNRG857_1313.NRG857_11005,iPC815.YPO1299,iSBO_1134.SBO_2156,iSDY_1059.SDY_2316,iSFV_1184.SFV_2243,iSF_1195.SF2253,iSFxv_1172.SFxv_2486,iS_1188.S2382,iUMN146_1321.UM146_05955,iUMNK88_1353.UMNK88_2713,iUTI89_1310.UTI89_C2443,iWFL_1372.ECW_m2369,iY75_1357.Y75_RS11345,iZ_1308.Z3426,ic_1306.c2703 Bacteria 2GK7E@201174,4E1A9@85010,COG1105@1,COG1105@2 NA|NA|NA H Belongs to the carbohydrate kinase PfkB family MAG.T1.179_02985 28444.JODQ01000007_gene5740 1.7e-78 299.3 Streptosporangiales ko:K02081,ko:K03436 ko00000,ko03000 Bacteria 2GKWM@201174,4EHNG@85012,COG1349@1,COG1349@2 NA|NA|NA K DeoR C terminal sensor domain MAG.T1.179_02987 331869.BAL199_00865 3.1e-12 79.0 Alphaproteobacteria Bacteria 1NKTM@1224,2DRFS@1,2UKVD@28211,33BIZ@2 NA|NA|NA MAG.T1.179_02988 1205680.CAKO01000026_gene4591 6.4e-205 719.9 Alphaproteobacteria Bacteria 1MU5U@1224,2TRIZ@28211,COG1804@1,COG1804@2 NA|NA|NA C L-carnitine dehydratase bile acid-inducible protein F MAG.T1.179_02989 1205680.CAKO01000026_gene4588 8.8e-110 403.3 Alphaproteobacteria aacC 2.3.1.81 ko:K00662 ko00000,ko01000,ko01504 Bacteria 1NBKU@1224,2UKEP@28211,COG2746@1,COG2746@2 NA|NA|NA V Aminoglycoside 3-N-acetyltransferase MAG.T1.179_02990 1205680.CAKO01000026_gene4587 3.1e-182 644.4 Rhodospirillales recA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360 ko:K03553 ko03440,map03440 M00729 ko00000,ko00001,ko00002,ko03400 Bacteria 1MU3C@1224,2JPIZ@204441,2TRPR@28211,COG0468@1,COG0468@2 NA|NA|NA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage MAG.T1.179_02991 1205680.CAKO01000026_gene4586 1.8e-90 339.0 Proteobacteria Bacteria 1NPI2@1224,COG0727@1,COG0727@2 NA|NA|NA S Putative zinc- or iron-chelating domain MAG.T1.179_02994 253839.SSNG_05645 7e-167 593.6 Actinobacteria metK GO:0003674,GO:0003824,GO:0004478,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0016740,GO:0016765,GO:0019899,GO:0030312,GO:0035375,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ4U@201174,COG0192@1,COG0192@2 NA|NA|NA H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme MAG.T1.179_02995 477641.MODMU_3312 7.1e-127 460.7 Frankiales coaBC GO:0003674,GO:0003824,GO:0004633,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016020,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJGJ@201174,4ERES@85013,COG0452@1,COG0452@2 NA|NA|NA H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine MAG.T1.179_02996 1306174.JODP01000013_gene7494 1.9e-32 144.8 Actinobacteria rpoZ GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030312,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03060 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 Bacteria 2IQHU@201174,COG1758@1,COG1758@2 NA|NA|NA K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits MAG.T1.179_02997 221359.RS9916_33432 1.5e-55 222.6 Synechococcus gmk GO:0003674,GO:0003824,GO:0004385,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8,4.1.1.23 ko:K00942,ko:K01591 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00050,M00051 R00332,R00965,R02090 RC00002,RC00409 ko00000,ko00001,ko00002,ko01000 iAPECO1_1312.APECO1_2813,iIT341.HP0321,iPC815.YPO0040,iSBO_1134.SBO_3729,iSFV_1184.SFV_3881,iSFxv_1172.SFxv_4016,iUTI89_1310.UTI89_C4193 Bacteria 1G515@1117,1GZ3I@1129,COG0194@1,COG0194@2 NA|NA|NA F Essential for recycling GMP and indirectly, cGMP MAG.T1.179_02998 1150398.JIBJ01000004_gene2893 1.2e-13 82.8 Micrococcaceae mihF 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 1W9UW@1268,2IKPU@201174,COG0099@1,COG0099@2 NA|NA|NA J integration host factor MAG.T1.179_02999 1123320.KB889665_gene1438 3.8e-72 278.1 Actinobacteria pyrF GO:0003674,GO:0003824,GO:0004590,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 iECO103_1326.ECO103_1444,iECSF_1327.ECSF_1264,iSFV_1184.SFV_1294,iSF_1195.SF1285,iSFxv_1172.SFxv_1457,iS_1188.S1368,ic_1306.c1750 Bacteria 2HPEA@201174,COG0284@1,COG0284@2 NA|NA|NA F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) MAG.T1.179_03000 477641.MODMU_3319 5.9e-119 434.1 Frankiales pyrD GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.98.1 ko:K00226,ko:K02823,ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01867,R01869 RC00051 ko00000,ko00001,ko00002,ko01000 iYO844.BSU15540 Bacteria 2GKC6@201174,4ERIP@85013,COG0167@1,COG0167@2 NA|NA|NA F Catalyzes the conversion of dihydroorotate to orotate MAG.T1.179_03001 367299.JOEE01000005_gene3472 4.1e-97 361.3 Intrasporangiaceae pyrK ko:K02823 ko00240,ko01100,map00240,map01100 ko00000,ko00001 Bacteria 2HQ24@201174,4FFS3@85021,COG0543@1,COG0543@2 NA|NA|NA C Dihydroorotate oxidase MAG.T1.179_03002 211114.JOEF01000010_gene3310 7.4e-119 433.7 Pseudonocardiales carB GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 iAF1260.b0033,iBWG_1329.BWG_0031,iECDH10B_1368.ECDH10B_0034,iECDH1ME8569_1439.ECDH1ME8569_0031,iECUMN_1333.ECUMN_0034,iEcDH1_1363.EcDH1_3566,iJN746.PP_4723,iJO1366.b0033,iJR904.b0033,iPC815.YPO0482,iY75_1357.Y75_RS00170,iYL1228.KPN_00041 Bacteria 2GK5N@201174,4E0DG@85010,COG0458@1,COG0458@2 NA|NA|NA EF Belongs to the CarB family MAG.T1.179_03003 159087.Daro_2237 1.8e-15 87.8 Betaproteobacteria GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 ko:K03546 ko00000,ko03400 Bacteria 1R4Z9@1224,2VMIM@28216,COG0419@1,COG0419@2 NA|NA|NA L ATPase involved in DNA repair MAG.T1.179_03004 106370.Francci3_3562 4.2e-206 724.2 Frankiales infB ko:K02519 ko00000,ko03012,ko03029 Bacteria 2GKPH@201174,4ERI2@85013,COG0532@1,COG0532@2 NA|NA|NA J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex MAG.T1.179_03005 591158.SSMG_04921 1.4e-28 132.1 Actinobacteria ylxP ko:K09764 ko00000 Bacteria 2IQW4@201174,COG1550@1,COG1550@2 NA|NA|NA S protein conserved in bacteria MAG.T1.179_03006 479433.Caci_7740 3.1e-49 201.4 Actinobacteria rbfA ko:K02834 ko00000,ko03009 Bacteria 2IKXP@201174,COG0858@1,COG0858@2 NA|NA|NA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA MAG.T1.179_03007 1304865.JAGF01000001_gene3790 1.1e-79 303.5 Cellulomonadaceae truB GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 ko:K03177 ko00000,ko01000,ko03016 Bacteria 2GJZK@201174,4F0NH@85016,COG0130@1,COG0130@2 NA|NA|NA J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs MAG.T1.179_03008 1283283.ATXA01000005_gene2038 3.8e-156 558.1 Frankiales pepP 3.4.11.9 ko:K01262 ko00000,ko01000,ko01002 Bacteria 2GM7D@201174,4ERTK@85013,COG0006@1,COG0006@2 NA|NA|NA E Creatinase/Prolidase N-terminal domain MAG.T1.179_03009 591157.SSLG_04999 2.9e-75 288.9 Actinobacteria ribF GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008531,GO:0009058,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009124,GO:0009156,GO:0009161,GO:0009165,GO:0009231,GO:0009259,GO:0009260,GO:0009398,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0034654,GO:0042364,GO:0042726,GO:0042727,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046390,GO:0046444,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKQF@201174,COG0196@1,COG0196@2 NA|NA|NA H Belongs to the ribF family MAG.T1.179_03010 28444.JODQ01000001_gene2722 1.6e-34 151.8 Streptosporangiales rpsO GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006378,GO:0006396,GO:0006397,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016071,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031123,GO:0031124,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043631,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02956 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IQA0@201174,4EK2G@85012,COG0184@1,COG0184@2 NA|NA|NA J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome MAG.T1.179_03011 1510531.JQJJ01000013_gene424 9.8e-38 162.5 Bradyrhizobiaceae ybeY GO:0000469,GO:0000478,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0006139,GO:0006355,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016072,GO:0016151,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0019219,GO:0019222,GO:0019538,GO:0022613,GO:0030490,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043244,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141 2.6.99.2,3.5.4.5 ko:K01489,ko:K03474,ko:K03595,ko:K07042 ko00240,ko00750,ko00983,ko01100,map00240,map00750,map00983,map01100 M00124 R01878,R02485,R05838,R08221 RC00074,RC00514,RC01476 ko00000,ko00001,ko00002,ko01000,ko03009,ko03029 Bacteria 1MZ67@1224,2UBXV@28211,3JWAC@41294,COG0319@1,COG0319@2 NA|NA|NA J Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA MAG.T1.179_03012 1510531.JQJJ01000013_gene423 3.1e-30 137.5 Bradyrhizobiaceae tlyC ko:K06189 ko00000,ko02000 9.A.40.1.2 Bacteria 1MV3P@1224,2TVFA@28211,3JSH4@41294,COG1253@1,COG1253@2 NA|NA|NA S Transporter associated domain MAG.T1.179_03014 1380354.JIAN01000005_gene2705 0.0 1347.0 Cellulomonadaceae lysS GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006430,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iAF1260.b4129,iECDH1ME8569_1439.ECDH1ME8569_3989,iECW_1372.ECW_m4490,iEcDH1_1363.EcDH1_3862,iJN678.lysS,iJO1366.b4129,iWFL_1372.ECW_m4490 Bacteria 2GKE0@201174,4F1Q9@85016,COG1190@1,COG1190@2,COG2898@1,COG2898@2 NA|NA|NA J Uncharacterised conserved protein (DUF2156) MAG.T1.179_03018 469383.Cwoe_1507 8.2e-30 137.1 Rubrobacteria ko:K03088 ko00000,ko03021 Bacteria 2IRNG@201174,4CTBE@84995,COG1595@1,COG1595@2 NA|NA|NA K Sigma-70 region 2 MAG.T1.179_03022 266940.Krad_3828 1e-124 453.8 Actinobacteria ko:K13527 ko03050,map03050 M00342 ko00000,ko00001,ko00002,ko03051 Bacteria 2IA0X@201174,COG1222@1,COG1222@2 NA|NA|NA O ATPase family associated with various cellular activities (AAA) MAG.T1.179_03023 222534.KB893711_gene5073 6.4e-25 120.6 Actinobacteria Bacteria 2ECTF@1,2GR5H@201174,336QZ@2 NA|NA|NA MAG.T1.179_03024 367299.JOEE01000004_gene1261 2.4e-32 144.8 Intrasporangiaceae ko:K10947 ko00000,ko03000 Bacteria 2IQ51@201174,4FJ5V@85021,COG1695@1,COG1695@2 NA|NA|NA K PadR family transcriptional regulator MAG.T1.179_03026 196162.Noca_1944 3.3e-58 231.9 Actinobacteria Bacteria 2ASZS@1,2IINR@201174,31IFG@2 NA|NA|NA MAG.T1.179_03027 561175.KB894095_gene2362 1.5e-68 266.9 Streptosporangiales rmuC ko:K09760 ko00000 Bacteria 2GP4U@201174,4EHTZ@85012,COG1322@1,COG1322@2 NA|NA|NA S RmuC family MAG.T1.179_03029 1380354.JIAN01000008_gene3433 3.2e-122 444.9 Cellulomonadaceae ispH 1.17.7.4,2.7.4.25 ko:K00945,ko:K02945,ko:K03527 ko00240,ko00900,ko01100,ko01110,ko01130,ko03010,map00240,map00900,map01100,map01110,map01130,map03010 M00052,M00096,M00178 R00158,R00512,R01665,R05884,R08210 RC00002,RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko03011 iIT341.HP0400,iLJ478.TM1444 Bacteria 2GIZ7@201174,4F107@85016,COG0761@1,COG0761@2 NA|NA|NA IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis MAG.T1.179_03030 321955.AAGP01000021_gene1877 6.4e-107 394.4 Brevibacteriaceae xseA GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 3.1.11.6 ko:K03601 ko03430,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 2GJAS@201174,4F8CF@85019,COG1570@1,COG1570@2 NA|NA|NA L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides MAG.T1.179_03031 593907.Celgi_0687 1.9e-11 75.1 Cellulomonadaceae xseB GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494 3.1.11.6 ko:K03602 ko03430,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 2GR0U@201174,4F2SG@85016,COG1722@1,COG1722@2 NA|NA|NA L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides MAG.T1.179_03032 1894.JOER01000030_gene419 2.2e-16 92.4 Actinobacteria Bacteria 2EID2@1,2IG1H@201174,33C4E@2 NA|NA|NA S Protein of unknown function (DUF4245) MAG.T1.179_03033 1048339.KB913029_gene2589 5.4e-95 354.4 Frankiales nuoN GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2GMGX@201174,4ERCH@85013,COG1007@1,COG1007@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient MAG.T1.179_03034 1380347.JNII01000005_gene3065 1.8e-195 688.7 Frankiales trpB 4.2.1.20 ko:K01696,ko:K06001 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 Bacteria 2GP7D@201174,4ES9G@85013,COG1350@1,COG1350@2 NA|NA|NA E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine MAG.T1.179_03035 1048339.KB913029_gene2590 2e-116 425.6 Frankiales hepS GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.5.1.30 ko:K00805 ko00900,ko01110,map00900,map01110 R09247 RC00279 ko00000,ko00001,ko01000,ko01006 Bacteria 2GMB4@201174,4ERU8@85013,COG0142@1,COG0142@2 NA|NA|NA H Belongs to the FPP GGPP synthase family MAG.T1.179_03036 285514.JNWO01000023_gene102 1.5e-79 303.1 Actinobacteria rarD ko:K05786 ko00000,ko02000 2.A.7.7 Bacteria 2GKCP@201174,COG2962@1,COG2962@2 NA|NA|NA S RarD protein MAG.T1.179_03037 1464048.JNZS01000019_gene2358 1.3e-48 200.3 Micromonosporales ko:K03294 ko00000 2.A.3.2 Bacteria 2GMFE@201174,4DD1H@85008,COG0589@1,COG0589@2 NA|NA|NA T Belongs to the universal stress protein A family MAG.T1.179_03038 1157637.KB892096_gene989 4.4e-29 134.0 Actinobacteria oorB 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2GMI5@201174,COG1013@1,COG1013@2 NA|NA|NA C Ferredoxin oxidoreductase MAG.T1.179_03039 1089455.MOPEL_096_01300 1.5e-21 108.6 Dermatophilaceae Bacteria 2GJSF@201174,4F6TC@85018,COG0500@1,COG2226@2 NA|NA|NA Q Putative S-adenosyl-L-methionine-dependent methyltransferase MAG.T1.179_03040 40571.JOEA01000002_gene4983 2.8e-18 99.8 Pseudonocardiales Bacteria 2B1K4@1,2I2R4@201174,32S9C@2,4E7BQ@85010 NA|NA|NA S Protein of unknown function (DUF3068) MAG.T1.179_03041 351607.Acel_1088 0.0 1082.4 Frankiales polA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 Bacteria 2GJY2@201174,4ES9K@85013,COG0258@1,COG0258@2,COG0749@1,COG0749@2 NA|NA|NA L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity MAG.T1.179_03042 1043205.AFYF01000075_gene2080 3.7e-36 157.9 Intrasporangiaceae ydiI Bacteria 2IKTU@201174,4FGPR@85021,COG2050@1,COG2050@2 NA|NA|NA Q protein possibly involved in aromatic compounds catabolism MAG.T1.179_03043 269800.Tfu_1187 1.5e-66 259.6 Actinobacteria ydfK ko:K07150 ko00000 Bacteria 2GM75@201174,COG1811@1,COG1811@2 NA|NA|NA S Na channel or pump MAG.T1.179_03044 1306174.JODP01000013_gene7452 2.4e-30 137.9 Actinobacteria ko:K01996 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 2GKSQ@201174,COG0410@1,COG0410@2 NA|NA|NA E ABC transporter MAG.T1.179_03045 479431.Namu_4836 2.4e-52 211.8 Frankiales alx ko:K05794 ko00000 Bacteria 2GIWU@201174,4ERNE@85013,COG0861@1,COG0861@2 NA|NA|NA P membrane protein, TerC MAG.T1.179_03046 1283283.ATXA01000007_gene3910 1.7e-120 440.3 Frankiales Bacteria 2GIZF@201174,4ERVM@85013,COG5001@1,COG5001@2 NA|NA|NA T Diguanylate cyclase MAG.T1.179_03047 590998.Celf_3653 8.9e-51 208.4 Actinobacteria Bacteria 2GIZF@201174,COG2202@1,COG2202@2,COG5001@1,COG5001@2,COG5002@1,COG5002@2 NA|NA|NA T signal transduction protein containing a membrane domain an EAL and a GGDEF domain MAG.T1.179_03048 1445613.JALM01000036_gene2693 1.6e-11 75.5 Pseudonocardiales Bacteria 2DGB7@1,2GV3X@201174,2ZV98@2,4E6RY@85010 NA|NA|NA MAG.T1.179_03049 1054860.KB913030_gene1900 2.1e-50 204.9 Actinobacteria ko:K06147 ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 Bacteria 2GITR@201174,COG1132@1,COG1132@2 NA|NA|NA V ABC transporter MAG.T1.179_03051 1268303.RHODMAR_5092 9.4e-38 164.5 Actinobacteria ko:K03496 ko00000,ko03036,ko04812 Bacteria 2IHZI@201174,COG1192@1,COG1192@2 NA|NA|NA D PFAM Cobyrinic acid a,c-diamide synthase MAG.T1.179_03053 1274.HX89_14490 9.9e-60 238.4 Actinobacteria Bacteria 2EWQ2@1,2IT4U@201174,33Q1X@2 NA|NA|NA MAG.T1.179_03055 196162.Noca_1100 1.1e-110 406.8 Propionibacteriales Bacteria 2GISN@201174,4DTGT@85009,COG0582@1,COG0582@2 NA|NA|NA L Belongs to the 'phage' integrase family MAG.T1.179_03057 1380356.JNIK01000021_gene4529 2.9e-11 73.9 Bacteria Bacteria COG0789@1,COG0789@2 NA|NA|NA K bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding MAG.T1.179_03059 1041522.MCOL_V222638 5.1e-63 248.4 Mycobacteriaceae Bacteria 23DYG@1762,2HU14@201174,COG3598@1,COG3598@2 NA|NA|NA L AAA domain MAG.T1.179_03063 1449976.KALB_374 4.7e-12 78.2 Pseudonocardiales Bacteria 2IFSD@201174,4E6ND@85010,COG1476@1,COG1476@2 NA|NA|NA K transcriptional regulators MAG.T1.179_03064 1101188.KI912157_gene288 4.3e-15 87.4 Actinobacteria Bacteria 2BH0A@1,2GUIE@201174,32B0E@2 NA|NA|NA MAG.T1.179_03066 861360.AARI_pI00280 1.9e-13 83.6 Actinobacteria Bacteria 2D2AG@1,2IARE@201174,32TCD@2 NA|NA|NA MAG.T1.179_03068 402881.Plav_0506 7.6e-27 126.3 Proteobacteria hup GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009889,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2001141 ko:K03530 ko00000,ko03032,ko03036,ko03400 Bacteria 1MZ5B@1224,COG0776@1,COG0776@2 NA|NA|NA L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions MAG.T1.179_03069 526227.Mesil_1241 6.2e-41 174.5 Deinococcus-Thermus ywdF GO:0003674,GO:0003824,GO:0016740,GO:0016757 ko:K20444 ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 Bacteria 1WIU0@1297,COG1216@1,COG1216@2 NA|NA|NA S Glycosyl transferase family 2 MAG.T1.179_03070 1089551.KE386572_gene2101 6.6e-46 191.0 unclassified Alphaproteobacteria ko:K02044 ko02010,map02010 M00223 ko00000,ko00001,ko00002,ko02000 3.A.1.9 Bacteria 1R6YE@1224,2U6QH@28211,4BS8E@82117,COG3221@1,COG3221@2 NA|NA|NA P ABC transporter, phosphonate, periplasmic substrate-binding protein MAG.T1.179_03071 535289.Dtpsy_2272 1.7e-42 179.5 Betaproteobacteria MA20_18540 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 Bacteria 1NUET@1224,2VV5Z@28216,COG0625@1,COG0625@2 NA|NA|NA O Glutathione S-transferase, N-terminal domain MAG.T1.179_03072 1211115.ALIQ01000079_gene3929 2.5e-157 562.0 Beijerinckiaceae gltX1 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 Bacteria 1MUCR@1224,2TRCI@28211,3N9QP@45404,COG0008@1,COG0008@2 NA|NA|NA J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) MAG.T1.179_03073 1282876.BAOK01000001_gene2471 1.3e-21 108.6 unclassified Alphaproteobacteria nadE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5,6.3.5.1 ko:K01916,ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00189,R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 Bacteria 1MU9U@1224,2TRAU@28211,4BPM2@82117,COG0171@1,COG0171@2,COG0388@1,COG0388@2 NA|NA|NA H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source MAG.T1.179_03074 1048339.KB913029_gene2736 0.0 1139.0 Frankiales rpoC GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 Bacteria 2GKWF@201174,4ERS7@85013,COG0086@1,COG0086@2 NA|NA|NA K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates MAG.T1.179_03076 446468.Ndas_5119 1.7e-53 215.3 Streptosporangiales rpsL GO:0000372,GO:0000375,GO:0000376,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008380,GO:0009058,GO:0009059,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010604,GO:0010628,GO:0015935,GO:0016070,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0031323,GO:0031325,GO:0032991,GO:0033120,GO:0034336,GO:0034337,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043484,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990145,GO:1990904 ko:K02950 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IHUF@201174,4EJ9N@85012,COG0048@1,COG0048@2 NA|NA|NA J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit MAG.T1.179_03077 755732.Fluta_0782 7e-51 206.8 Cryomorphaceae rpsG GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0016020,GO:0016043,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 ko:K02992 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1HWP7@117743,2PAQE@246874,4NEEM@976,COG0049@1,COG0049@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA MAG.T1.179_03078 682795.AciX8_3222 1.7e-44 186.4 Acidobacteriia yagE Bacteria 2JMAA@204432,3Y43W@57723,COG1723@1,COG1723@2 NA|NA|NA S PFAM Uncharacterised ACR, YagE family COG1723 MAG.T1.179_03079 443218.AS9A_2686 1.4e-16 92.8 Actinobacteria Bacteria 2I3ZU@201174,COG3832@1,COG3832@2 NA|NA|NA S Polyketide cyclase / dehydrase and lipid transport MAG.T1.179_03080 1379270.AUXF01000001_gene2066 3.9e-74 285.4 Bacteria Bacteria COG2206@1,COG2206@2 NA|NA|NA T PFAM metal-dependent phosphohydrolase, HD sub domain MAG.T1.179_03081 1116369.KB890027_gene4940 6.2e-76 290.4 Phyllobacteriaceae glyA 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUIS@1224,2TQKT@28211,43NC8@69277,COG0112@1,COG0112@2 NA|NA|NA E Serine hydroxymethyltransferase MAG.T1.179_03082 398580.Dshi_5008 4.9e-59 234.2 Alphaproteobacteria sdaA 4.3.1.17 ko:K01752 ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230 R00220,R00590 RC00331,RC02600 ko00000,ko00001,ko01000 Bacteria 1MUZN@1224,2TR3D@28211,COG1760@1,COG1760@2 NA|NA|NA E COG1760 L-serine deaminase MAG.T1.179_03083 882083.SacmaDRAFT_4675 9.1e-52 210.3 Actinobacteria Bacteria 2IAWJ@201174,COG2345@1,COG2345@2 NA|NA|NA K Transcriptional regulator MAG.T1.179_03084 1385519.N801_04435 3.3e-25 120.9 Intrasporangiaceae Bacteria 2GS7C@201174,4FHNY@85021,COG4309@1,COG4309@2 NA|NA|NA S Uncharacterized conserved protein (DUF2249) MAG.T1.179_03085 1385519.N801_18595 1.7e-35 155.6 Intrasporangiaceae Bacteria 2IK6G@201174,4FH99@85021,COG3945@1,COG3945@2 NA|NA|NA S Hemerythrin HHE cation binding domain MAG.T1.179_03086 1121946.AUAX01000012_gene6510 7.5e-25 119.8 Micromonosporales hcaC ko:K05710 ko00360,ko01120,ko01220,map00360,map01120,map01220 M00545 R06782,R06783 RC00098 br01602,ko00000,ko00001,ko00002 Bacteria 2IQK7@201174,4DEJP@85008,COG2146@1,COG2146@2 NA|NA|NA P Rieske-like [2Fe-2S] domain MAG.T1.179_03087 1283283.ATXA01000012_gene4764 3e-35 154.5 Frankiales Bacteria 2IQI4@201174,4ET66@85013,COG1917@1,COG1917@2 NA|NA|NA S conserved protein, contains double-stranded beta-helix domain MAG.T1.179_03088 1906.SFRA_22065 9.2e-46 190.3 Bacteria Bacteria COG1309@1,COG1309@2 NA|NA|NA K transcriptional regulator MAG.T1.179_03090 243924.LT42_10670 1.5e-69 270.4 Gammaproteobacteria Bacteria 1P2C7@1224,1RZDU@1236,COG0323@1,COG0323@2 NA|NA|NA L COG0323 DNA mismatch repair enzyme MAG.T1.179_03091 398767.Glov_0290 1.8e-39 169.9 Deltaproteobacteria ko:K07451,ko:K07453 ko00000,ko01000,ko02048 Bacteria 1MZRA@1224,2WRC6@28221,42W8N@68525,COG3183@1,COG3183@2 NA|NA|NA L PFAM HNH endonuclease MAG.T1.179_03092 526225.Gobs_2978 7.9e-19 101.3 Frankiales ko:K14059 ko00000 Bacteria 2I6VQ@201174,4EXH7@85013,COG4974@1,COG4974@2 NA|NA|NA L Phage integrase family MAG.T1.179_03096 105422.BBPM01000015_gene1944 1.2e-46 192.6 Streptacidiphilus sdhD ko:K00242,ko:K00246 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00149,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002 Bacteria 2GNKE@201174,2NI1D@228398,COG2142@1,COG2142@2 NA|NA|NA C Succinate dehydrogenase/Fumarate reductase transmembrane subunit MAG.T1.179_03097 656024.FsymDg_0997 2.5e-49 201.4 Actinobacteria sdhC ko:K00241,ko:K00247 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00149,M00150,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002 Bacteria 2IKU7@201174,COG2009@1,COG2009@2 NA|NA|NA C succinate dehydrogenase MAG.T1.179_03098 1133850.SHJG_5992 5e-234 817.0 Actinobacteria bhbA 5.4.99.2 ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 Bacteria 2GM65@201174,COG1884@1,COG1884@2 NA|NA|NA I Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly MAG.T1.179_03099 1157638.KB892158_gene5453 2.4e-123 448.7 Actinobacteria add GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009119,GO:0009163,GO:0009164,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659 3.5.4.4 ko:K01488 ko00230,ko01100,ko05340,map00230,map01100,map05340 R01560,R02556 RC00477 ko00000,ko00001,ko01000 iNJ661.Rv3313c Bacteria 2GJ6I@201174,COG1816@1,COG1816@2 NA|NA|NA F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism MAG.T1.179_03100 1278078.G419_15843 2.3e-21 108.6 Nocardiaceae deoC GO:0003674,GO:0003824,GO:0004139,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 4.1.2.4 ko:K01619 ko00030,map00030 R01066 RC00436,RC00437 ko00000,ko00001,ko01000 iSB619.SA_RS00835 Bacteria 2GJIR@201174,4FX02@85025,COG0274@1,COG0274@2 NA|NA|NA F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate MAG.T1.179_03102 68170.KL590469_gene1813 8.4e-23 113.6 Pseudonocardiales 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2GJP5@201174,4E3JM@85010,COG0377@1,COG0377@2 NA|NA|NA C NADH ubiquinone oxidoreductase, 20 Kd subunit MAG.T1.179_03103 644283.Micau_5568 9.5e-22 110.2 Micromonosporales nuoC2 1.6.5.3 ko:K00332,ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2GNVP@201174,4DBTZ@85008,COG0852@1,COG0852@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain MAG.T1.179_03104 1051006.HMPREF1162_1975 2.1e-27 128.3 Actinobacteria nuoI 1.6.5.3 ko:K00338,ko:K03615,ko:K05580 ko00190,ko01100,map00190,map01100 M00144,M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2GPSS@201174,COG1143@1,COG1143@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient MAG.T1.179_03105 411471.SUBVAR_05270 2.1e-48 199.1 Ruminococcaceae pgp GO:0003674,GO:0003824,GO:0004672,GO:0004713,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018108,GO:0018193,GO:0018212,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046777,GO:0071704,GO:0140096,GO:1901564 3.1.3.18 ko:K01091,ko:K07025 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 R01334 RC00017 ko00000,ko00001,ko01000 Bacteria 1V1FQ@1239,24G1U@186801,3WITI@541000,COG0546@1,COG0546@2 NA|NA|NA S Psort location Cytoplasmic, score MAG.T1.179_03106 1041522.MCOL_V200460 2.2e-58 231.9 Mycobacteriaceae trpF GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 ko:K09767 ko00000 Bacteria 232N6@1762,2IFIU@201174,COG1666@1,COG1666@2 NA|NA|NA S Belongs to the UPF0234 family MAG.T1.179_03108 1203605.HMPREF1531_01270 1.2e-63 250.0 Propionibacteriales bdbD Bacteria 2IGR9@201174,4DRI0@85009,COG1651@1,COG1651@2 NA|NA|NA O Thioredoxin MAG.T1.179_03109 1203605.HMPREF1531_01269 3.1e-71 275.4 Actinobacteria dsbD Bacteria 2GMXW@201174,COG0785@1,COG0785@2 NA|NA|NA O cytochrome c biogenesis protein MAG.T1.179_03110 1304865.JAGF01000001_gene1880 1.3e-77 296.6 Cellulomonadaceae rarD ko:K05786 ko00000,ko02000 2.A.7.7 Bacteria 2GKCP@201174,4F0E2@85016,COG2962@1,COG2962@2 NA|NA|NA S EamA-like transporter family MAG.T1.179_03112 35754.JNYJ01000028_gene6039 6e-07 62.4 Micromonosporales int ko:K06400 ko00000 Bacteria 2I8HV@201174,4DM0R@85008,COG1961@1,COG1961@2 NA|NA|NA L Recombinase zinc beta ribbon domain MAG.T1.179_03114 479431.Namu_3045 1.3e-192 679.5 Actinobacteria Bacteria 2GM4J@201174,COG4584@1,COG4584@2 NA|NA|NA L Transposase MAG.T1.179_03115 1141663.OOC_10266 9.6e-21 107.5 Providencia yjjP GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0008150,GO:0015711,GO:0015740,GO:0015744,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071944 Bacteria 1NH2X@1224,1RN1Q@1236,3Z7GC@586,COG2966@1,COG2966@2 NA|NA|NA S Psort location CytoplasmicMembrane, score MAG.T1.179_03116 944547.ABLL_0461 1.1e-12 80.1 Epsilonproteobacteria yjjB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006950,GO:0006970,GO:0008150,GO:0009628,GO:0010033,GO:0010243,GO:0015711,GO:0015740,GO:0015744,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0042221,GO:0042493,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071944,GO:1901652,GO:1901698,GO:1901700 Bacteria 1RAWK@1224,2YNRX@29547,42QRH@68525,COG3610@1,COG3610@2 NA|NA|NA S Threonine/Serine exporter, ThrE MAG.T1.179_03118 391037.Sare_1005 1.1e-59 236.1 Micromonosporales bcp GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016020,GO:0016209,GO:0016491,GO:0016667,GO:0016671,GO:0016684,GO:0032843,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0070887,GO:0071944,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 ko:K03564 ko00000,ko01000 iPC815.YPO3064 Bacteria 2IHZ6@201174,4D9TD@85008,COG1225@1,COG1225@2 NA|NA|NA O alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen MAG.T1.179_03120 710111.FraQA3DRAFT_5821 2e-42 178.7 Frankiales iscR 2.8.1.7 ko:K04487,ko:K13643 ko00730,ko01100,ko04122,map00730,map01100,map04122 R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03000,ko03016,ko03029 Bacteria 2INF3@201174,4ESZ6@85013,COG1959@1,COG1959@2 NA|NA|NA K transcriptional regulator, Rrf2 family MAG.T1.179_03122 1206732.BAGD01000097_gene4238 2.8e-32 145.6 Nocardiaceae Bacteria 2IMKC@201174,4G03M@85025,COG2021@1,COG2021@2 NA|NA|NA E Serine aminopeptidase, S33 MAG.T1.179_03124 1043493.BBLU01000002_gene1838 5.7e-31 141.4 Bacteria ko:K16129 ko01054,map01054 ko00000,ko00001,ko01008 Bacteria COG0500@1,COG2226@2 NA|NA|NA Q methyltransferase MAG.T1.179_03126 1169152.AXVD01000023_gene3257 4.9e-15 88.2 Nocardiaceae ydiN ko:K03762 ko00000,ko02000 2.A.1.6.4 Bacteria 2HHY4@201174,4G1MV@85025,COG0477@1,COG0477@2,COG0500@1,COG2226@2 NA|NA|NA Q Mycolic acid cyclopropane synthetase MAG.T1.179_03128 1184609.KILIM_108_00060 3.8e-145 521.5 Dermatophilaceae hsdR 3.1.21.3 ko:K01153 ko00000,ko01000,ko02048 Bacteria 2HI69@201174,4F84F@85018,COG0610@1,COG0610@2 NA|NA|NA V Type I restriction enzyme R protein N terminus (HSDR_N) MAG.T1.179_03129 1068978.AMETH_4699 7.1e-96 358.6 Actinobacteria Bacteria 2GNC5@201174,COG4928@1,COG4928@2 NA|NA|NA S KAP family P-loop domain MAG.T1.179_03131 1304865.JAGF01000001_gene1014 1.4e-50 206.5 Actinobacteria kcsA ko:K10716 ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 Bacteria 2GKNF@201174,COG1226@1,COG1226@2 NA|NA|NA P Ion transport 2 domain protein MAG.T1.179_03135 471853.Bcav_2527 1.7e-19 102.1 Actinobacteria Bacteria 2DXDW@1,2GSPD@201174,344MC@2 NA|NA|NA MAG.T1.179_03139 1089553.Tph_c23820 4.8e-137 495.0 Thermoanaerobacterales Bacteria 1TPAA@1239,2492T@186801,42FY1@68295,COG5421@1,COG5421@2 NA|NA|NA L Best Blastp hit gi 4323609 gb AAD16446.1 (AF101410) transposase Mycoplasma mycoides subsp. mycoides SC gi 4323611 gb AAD16447.1 (AF101411) transposase Mycoplasma mycoides subsp. mycoides SC gi 4323613 gb AAD16448.1 (AF101412) transposase Mycoplasma mycoides subsp. mycoides SC , score MAG.T1.179_03140 391625.PPSIR1_34792 2.7e-33 149.1 Deltaproteobacteria cfl 6.2.1.3 ko:K01897,ko:K03822 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 Bacteria 1MWSD@1224,2WM9N@28221,42Q72@68525,COG0318@1,COG0318@2,COG3243@1,COG3243@2 NA|NA|NA IQ PFAM AMP-dependent synthetase and ligase MAG.T1.179_03141 591159.ACEZ01000200_gene2508 5.6e-37 160.6 Actinobacteria chrB Bacteria 2IPJU@201174,COG4275@1,COG4275@2 NA|NA|NA S Chromate resistance exported protein MAG.T1.179_03142 134676.ACPL_4271 3.5e-60 237.7 Actinobacteria Bacteria 2IK0B@201174,COG4275@1,COG4275@2 NA|NA|NA S chromate resistance protein MAG.T1.179_03143 460265.Mnod_6097 6.4e-124 451.1 Methylobacteriaceae chrA ko:K07240 ko00000,ko02000 2.A.51.1 Bacteria 1JRJU@119045,1MUBW@1224,2TRXF@28211,COG2059@1,COG2059@2 NA|NA|NA P TIGRFAM chromate transporter, chromate ion transporter (CHR) family MAG.T1.179_03146 1177928.TH2_05358 4.1e-37 161.0 Rhodospirillales Bacteria 1R3EV@1224,2BWGA@1,2JUQK@204441,2U73F@28211,30D7C@2 NA|NA|NA MAG.T1.179_03147 1121271.AUCM01000048_gene571 6.6e-22 109.4 Alphaproteobacteria Bacteria 1NC2Y@1224,2E5DP@1,2UGVN@28211,3305P@2 NA|NA|NA MAG.T1.179_03149 935567.JAES01000010_gene1789 8.4e-31 139.4 Xanthomonadales ko:K06975 ko00000 Bacteria 1N8AQ@1224,1SH12@1236,1X83J@135614,COG2388@1,COG2388@2 NA|NA|NA S acetyltransferase MAG.T1.179_03150 1306174.JODP01000013_gene7453 6e-101 374.0 Actinobacteria ko:K01995 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 2GMEE@201174,COG0411@1,COG0411@2 NA|NA|NA E ABC transporter MAG.T1.179_03151 1306174.JODP01000013_gene7454 5.4e-127 461.1 Actinobacteria livM ko:K01998 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 2GJB3@201174,COG4177@1,COG4177@2 NA|NA|NA E Belongs to the binding-protein-dependent transport system permease family MAG.T1.179_03152 1306174.JODP01000013_gene7455 3.1e-102 378.6 Actinobacteria ko:K01997 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 2GMAY@201174,COG0559@1,COG0559@2 NA|NA|NA E Belongs to the binding-protein-dependent transport system permease family MAG.T1.179_03153 367299.JOEE01000004_gene1013 3.1e-88 332.4 Bacteria ko:K08642 ko02024,map02024 ko00000,ko00001,ko01000,ko01002 Bacteria COG0739@1,COG0739@2 NA|NA|NA M heme binding MAG.T1.179_03154 1304865.JAGF01000001_gene2476 1.3e-203 715.7 Cellulomonadaceae gltA 1.18.1.2,1.19.1.1,1.4.1.13,1.4.1.14 ko:K00266,ko:K00528,ko:K02823 ko00240,ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00240,map00250,map00910,map01100,map01110,map01120,map01130,map01230 R00093,R00114,R00248,R10159 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 Bacteria 2GJ0A@201174,4F0FS@85016,COG0493@1,COG0493@2,COG0543@1,COG0543@2 NA|NA|NA E TIGRFAM glutamate synthase, NADH NADPH, small subunit MAG.T1.179_03155 350058.Mvan_1143 1.2e-81 311.6 Mycobacteriaceae Bacteria 234MG@1762,2GMRR@201174,COG3012@1,COG3012@2 NA|NA|NA S SEC-C motif MAG.T1.179_03156 522306.CAP2UW1_0150 3.3e-308 1063.9 unclassified Betaproteobacteria cusA ko:K07787,ko:K15726 ko02020,map02020 ko00000,ko00001,ko02000 2.A.6.1.2,2.A.6.1.4 iAF987.Gmet_1547 Bacteria 1KQHT@119066,1NUIV@1224,2VHCZ@28216,COG3696@1,COG3696@2 NA|NA|NA P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family MAG.T1.179_03158 1445613.JALM01000042_gene1781 3.9e-213 747.7 Pseudonocardiales GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 2GM4J@201174,4E0HE@85010,COG4584@1,COG4584@2 NA|NA|NA L Integrase core domain MAG.T1.179_03159 1445613.JALM01000042_gene1780 9.2e-112 409.8 Pseudonocardiales GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0022616,GO:0034641,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1901576 Bacteria 2H714@201174,4E1MA@85010,COG1484@1,COG1484@2 NA|NA|NA L Bacterial dnaA protein MAG.T1.179_03160 1121946.AUAX01000020_gene3142 7.3e-164 584.3 Micromonosporales Bacteria 2HH0Q@201174,4DAQP@85008,COG1524@1,COG1524@2 NA|NA|NA S Type I phosphodiesterase / nucleotide pyrophosphatase MAG.T1.179_03161 452652.KSE_47800 3.9e-101 374.4 Kitasatospora fumB GO:0003674,GO:0003824,GO:0004333,GO:0005488,GO:0005515,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016860,GO:0016862,GO:0016999,GO:0017144,GO:0019752,GO:0033554,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0047808,GO:0048037,GO:0050163,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0055114,GO:0071704,GO:0072350 4.2.1.2 ko:K01676,ko:K01677,ko:K01678 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 iEC55989_1330.EC55989_1778,iPC815.YPO3335 Bacteria 2GK6D@201174,2M06I@2063,COG1838@1,COG1838@2,COG1951@1,COG1951@2 NA|NA|NA C Catalyzes the reversible hydration of fumarate to (S)- malate MAG.T1.179_03162 85643.Tmz1t_3672 2.3e-79 301.6 Rhodocyclales mobA 2.7.4.9,2.7.7.77,3.6.1.15,3.6.1.55,3.6.3.29,3.6.3.34 ko:K00943,ko:K02013,ko:K02017,ko:K03574,ko:K03752,ko:K06928 ko00230,ko00240,ko00730,ko00790,ko01100,ko02010,map00230,map00240,map00730,map00790,map01100,map02010 M00053,M00189,M00240 R00086,R00615,R02094,R02098,R11581 RC00002 ko00000,ko00001,ko00002,ko01000,ko02000,ko03400 3.A.1.14,3.A.1.8 Bacteria 1RHUK@1224,2KYMY@206389,2VS2I@28216,COG1618@1,COG1618@2 NA|NA|NA F Protein of unknown function (DUF2478) MAG.T1.179_03163 497321.C664_17957 5.2e-21 106.3 Betaproteobacteria yeiW ko:K06940 ko00000 Bacteria 1MZCU@1224,2VYSV@28216,32S46@2,COG0727@1 NA|NA|NA S Fe-S-cluster oxidoreductase MAG.T1.179_03165 666684.AfiDRAFT_3380 7e-43 181.0 Bradyrhizobiaceae efeU_1 ko:K07243 ko00000,ko02000 2.A.108.1,2.A.108.2 Bacteria 1MXHM@1224,2U17C@28211,3JWFW@41294,COG0672@1,COG0672@2 NA|NA|NA P Iron permease FTR1 family MAG.T1.179_03166 1054213.HMPREF9946_04303 2.1e-70 272.7 Alphaproteobacteria lasA Bacteria 1MY2J@1224,2CCV8@1,2TUT1@28211,2Z7KX@2 NA|NA|NA S EcsC protein family MAG.T1.179_03175 1144319.PMI16_04806 1.8e-200 705.3 Oxalobacteraceae Bacteria 1PSIQ@1224,2W1RA@28216,477ZM@75682,COG0582@1,COG0582@2 NA|NA|NA L Belongs to the 'phage' integrase family MAG.T1.179_03176 1123242.JH636435_gene1059 1.1e-74 287.0 Bacteria inlA ko:K13730 ko05100,map05100 ko00000,ko00001 Bacteria COG4886@1,COG4886@2 NA|NA|NA S regulation of response to stimulus MAG.T1.179_03177 1123242.JH636435_gene3054 2.1e-27 128.3 Planctomycetes recA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360 ko:K03553 ko03440,map03440 M00729 ko00000,ko00001,ko00002,ko03400 Bacteria 2IX4U@203682,COG0468@1,COG0468@2 NA|NA|NA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage MAG.T1.179_03178 1453503.AU05_08205 5.4e-123 447.2 Pseudomonas aeruginosa group xylB2 2.7.1.17 ko:K00854 ko00040,ko01100,map00040,map01100 M00014 R01639 RC00002,RC00538 ko00000,ko00001,ko00002,ko01000 Bacteria 1MW4A@1224,1RR7X@1236,1YDGK@136841,COG1070@1,COG1070@2 NA|NA|NA G FGGY family of carbohydrate kinases, N-terminal domain MAG.T1.179_03179 644283.Micau_3124 2.5e-49 201.4 Micromonosporales 4.3.1.14 ko:K18014 ko00310,map00310 R03030 RC00833 ko00000,ko00001,ko01000 Bacteria 2IKM2@201174,4DDMP@85008,COG1607@1,COG1607@2 NA|NA|NA I Thioesterase superfamily MAG.T1.179_03180 1121017.AUFG01000005_gene1069 2.1e-100 372.1 Intrasporangiaceae kamE 5.4.3.3,5.4.3.5 ko:K17898,ko:K18011 ko00310,ko00472,map00310,map00472 R02461,R02852,R03275 RC00719 ko00000,ko00001,ko01000 Bacteria 2HF50@201174,4FFS0@85021,COG2185@1,COG2185@2 NA|NA|NA I Lysine 5,6-aminomutase subunit beta MAG.T1.179_03181 196162.Noca_2663 1.9e-53 215.3 Propionibacteriales deoC GO:0003674,GO:0003824,GO:0004139,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 4.1.2.4,5.4.3.3 ko:K01619,ko:K01844 ko00030,ko00310,map00030,map00310 R01066,R02852,R03275 RC00436,RC00437,RC00719 ko00000,ko00001,ko01000 Bacteria 2GUM7@201174,4DNH2@85009,COG0274@1,COG0274@2 NA|NA|NA F D-Lysine 5,6-aminomutase TIM-barrel domain of alpha subunit MAG.T1.179_03182 1463853.JOHW01000024_gene4682 5.7e-201 707.2 Actinobacteria gyrA GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0008094,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0034335,GO:0042623,GO:0061505,GO:0140097 5.99.1.3 ko:K02469 ko00000,ko01000,ko03032,ko03400 Bacteria 2GJ2Q@201174,COG0188@1,COG0188@2 NA|NA|NA L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner MAG.T1.179_03183 1449353.JQMQ01000005_gene3018 1.6e-24 119.4 Streptacidiphilus GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 Bacteria 2GKZP@201174,2NIAK@228398,COG3266@1,COG3266@2 NA|NA|NA S Transmembrane domain of unknown function (DUF3566) MAG.T1.179_03185 1120950.KB892811_gene7249 8.8e-09 66.2 Propionibacteriales Bacteria 2GITW@201174,4DPHM@85009,COG1167@1,COG1167@2 NA|NA|NA K helix_turn_helix gluconate operon transcriptional repressor MAG.T1.179_03186 1278078.G419_22129 2.2e-109 402.1 Nocardiaceae ppk2 2.7.4.1 ko:K22468 ko00190,ko03018,map00190,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 2GKRN@201174,4FVD3@85025,COG2326@1,COG2326@2 NA|NA|NA S polyphosphate kinase MAG.T1.179_03187 477641.MODMU_4109 1.1e-32 146.7 Frankiales ligA GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 2.7.7.7,6.5.1.2 ko:K01972,ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03430,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03430,map03440 M00260 R00375,R00376,R00377,R00378,R00382 RC00005,RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 2GJZ0@201174,4EWD5@85013,COG0272@1,COG0272@2,COG0847@1,COG0847@2 NA|NA|NA L EXOIII MAG.T1.179_03194 1048339.KB913029_gene2735 5.1e-194 683.7 Frankiales rpoB GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 Bacteria 2GJ81@201174,4ES8S@85013,COG0085@1,COG0085@2 NA|NA|NA K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates MAG.T1.179_03197 1151122.AQYD01000004_gene2678 8.2e-59 233.0 Actinobacteria Bacteria 2H4W1@201174,COG1082@1,COG1082@2 NA|NA|NA G Xylose isomerase domain protein TIM barrel MAG.T1.179_03198 1151122.AQYD01000004_gene2679 1.6e-54 218.4 Actinobacteria Bacteria 2EXVQ@1,2IDZ0@201174,33R4U@2 NA|NA|NA S SnoaL-like domain MAG.T1.179_03199 196162.Noca_1100 2.2e-124 452.6 Propionibacteriales Bacteria 2GISN@201174,4DTGT@85009,COG0582@1,COG0582@2 NA|NA|NA L Belongs to the 'phage' integrase family MAG.T1.179_03204 65497.JODV01000007_gene534 4e-82 310.8 Pseudonocardiales menB GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0008150,GO:0008152,GO:0008935,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0042180,GO:0042181,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:0071890,GO:1901576,GO:1901661,GO:1901663 4.1.3.36 ko:K01661 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R07263 RC01923 ko00000,ko00001,ko00002,ko01000 iJN678.menB,iYL1228.KPN_02660 Bacteria 2GK5G@201174,4E09A@85010,COG0447@1,COG0447@2 NA|NA|NA H Belongs to the enoyl-CoA hydratase isomerase family. MenB subfamily MAG.T1.179_03206 1001240.GY21_10560 2.5e-25 122.5 Microbacteriaceae Bacteria 2BDA2@1,2HCIB@201174,326YG@2,4FSVK@85023 NA|NA|NA MAG.T1.179_03207 1177594.MIC448_820029 2.7e-14 84.7 Microbacteriaceae Bacteria 2BDA2@1,2HCIB@201174,326YG@2,4FSVK@85023 NA|NA|NA MAG.T1.179_03208 1502852.FG94_02656 8.7e-18 98.6 Betaproteobacteria 2.7.7.65 ko:K21084 ko02026,map02026 ko00000,ko00001,ko01000 Bacteria 1MU2C@1224,2WHYW@28216,COG5001@1,COG5001@2 NA|NA|NA T diguanylate cyclase MAG.T1.179_03209 1120959.ATXF01000004_gene2858 1.4e-107 396.0 Microbacteriaceae 2.5.1.48,4.4.1.11,4.4.1.8 ko:K01739,ko:K01760,ko:K01761 ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017 R00654,R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04941,R04944,R04945,R04946 RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ5S@201174,4FMTB@85023,COG0626@1,COG0626@2 NA|NA|NA E Cys/Met metabolism PLP-dependent enzyme MAG.T1.179_03210 1120960.ATXG01000002_gene3122 7e-118 430.3 Microbacteriaceae sdrA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 2GIU5@201174,4FM8J@85023,COG1061@1,COG1061@2 NA|NA|NA L Type III restriction enzyme, res subunit MAG.T1.179_03211 1298880.AUEV01000001_gene5984 6.5e-24 118.6 Actinobacteria Bacteria 2GPWU@201174,COG0323@1,COG0323@2 NA|NA|NA L PFAM Relaxase mobilization nuclease family protein MAG.T1.179_03213 1123072.AUDH01000023_gene761 6e-45 186.8 Rhodospirillales Bacteria 1QV28@1224,2E7ZA@1,2JZ2Y@204441,2TW8N@28211,2ZFZF@2 NA|NA|NA S Protein of unknown function (DUF2924) MAG.T1.179_03216 323097.Nham_2867 1.4e-179 635.6 Bradyrhizobiaceae dnaG ko:K02316 ko03030,map03030 ko00000,ko00001,ko01000,ko03032 Bacteria 1MUHC@1224,2TRU2@28211,3JQWZ@41294,COG0358@1,COG0358@2 NA|NA|NA L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication MAG.T1.179_03217 1121271.AUCM01000014_gene2726 1.1e-22 112.8 Proteobacteria Bacteria 1NG9Z@1224,2EIFE@1,33C6S@2 NA|NA|NA MAG.T1.179_03218 1231190.NA8A_22131 1.2e-07 61.6 Phyllobacteriaceae ybgT GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008152,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0019867,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0055114,GO:0071944 1.10.3.14 ko:K00424 ko00190,ko02020,map00190,map02020 M00153 ko00000,ko00001,ko01000 3.D.4.3 Bacteria 1PVJJ@1224,2V4Y1@28211,43QH5@69277,COG4890@1,COG4890@2 NA|NA|NA S Membrane bound YbgT-like protein MAG.T1.179_03219 1231190.NA8A_10778 1.8e-70 272.3 Phyllobacteriaceae cydB 1.10.3.14 ko:K00426 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 iYO844.BSU38750 Bacteria 1MURP@1224,2TU3I@28211,43JDK@69277,COG1294@1,COG1294@2 NA|NA|NA C oxidase, subunit MAG.T1.179_03226 420662.Mpe_A2644 1.1e-23 116.7 unclassified Burkholderiales Bacteria 1KMIK@119065,1NBYM@1224,2VXG9@28216,COG3678@1,COG3678@2 NA|NA|NA NPTU Heavy-metal resistance MAG.T1.179_03228 1287116.X734_30655 3.6e-109 401.4 Phyllobacteriaceae purU 3.5.1.10 ko:K01433 ko00630,ko00670,map00630,map00670 R00944 RC00026,RC00111 ko00000,ko00001,ko01000 Bacteria 1MVCF@1224,2TR4V@28211,43HVQ@69277,COG0788@1,COG0788@2 NA|NA|NA F Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) MAG.T1.179_03229 1120956.JHZK01000023_gene1112 6.4e-14 82.8 Alphaproteobacteria metF3 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 Bacteria 1MXTZ@1224,2TWKE@28211,COG0685@1,COG0685@2 NA|NA|NA E reductase MAG.T1.179_03230 1385519.N801_12240 5.6e-31 141.0 Intrasporangiaceae ko:K07075 ko00000 Bacteria 2GV48@201174,4FI55@85021,COG1669@1,COG1669@2 NA|NA|NA S Nucleotidyltransferase domain MAG.T1.179_03231 1121924.ATWH01000005_gene2614 1.7e-27 128.6 Microbacteriaceae Bacteria 2GXCS@201174,4FSF8@85023,COG2361@1,COG2361@2 NA|NA|NA S Protein of unknown function DUF86 MAG.T1.179_03233 314264.ROS217_22577 5.6e-15 86.7 Roseovarius ko:K09796 ko00000,ko03110 Bacteria 1MZ3M@1224,2UBUR@28211,46QU6@74030,COG2847@1,COG2847@2 NA|NA|NA S Copper chaperone PCu(A)C MAG.T1.179_03235 1385515.N791_06180 4.4e-11 73.9 Xanthomonadales hisS 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 1MV2K@1224,1SKNI@1236,1X5G2@135614,COG0124@1,COG0124@2 NA|NA|NA J histidyl-tRNA synthetase MAG.T1.179_03236 765420.OSCT_0409 1.4e-21 110.2 Chloroflexi Bacteria 2G8I9@200795,COG2234@1,COG2234@2 NA|NA|NA S Peptidase family M28 MAG.T1.179_03238 1207063.P24_04604 6.3e-14 84.0 Rhodospirillales ygiF 3.6.1.25,4.6.1.1 ko:K01768,ko:K18446 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 Bacteria 1MY43@1224,2JQ4S@204441,2TQRV@28211,COG3025@1,COG3025@2,COG5607@1,COG5607@2 NA|NA|NA S CYTH MAG.T1.179_03239 479435.Kfla_2235 3.1e-42 177.9 Propionibacteriales glbO GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008144,GO:0008150,GO:0015669,GO:0015671,GO:0015893,GO:0016020,GO:0019825,GO:0020037,GO:0036094,GO:0042221,GO:0042493,GO:0044464,GO:0046906,GO:0048037,GO:0050896,GO:0051179,GO:0051234,GO:0071944,GO:0097159,GO:1901363 ko:K06886 ko00000 Bacteria 2IKPF@201174,4DR1I@85009,COG2346@1,COG2346@2 NA|NA|NA S Bacterial-like globin MAG.T1.179_03240 710696.Intca_1360 1e-16 92.8 Intrasporangiaceae ko:K22044 ko00000,ko02000 1.A.23.3 Bacteria 2GMFK@201174,4FF0H@85021,COG0668@1,COG0668@2 NA|NA|NA M mechanosensitive ion channel protein MscS MAG.T1.179_03242 314230.DSM3645_09472 9.6e-07 60.5 Bacteria Bacteria 2CHP8@1,2ZAVY@2 NA|NA|NA MAG.T1.179_03243 314230.DSM3645_09497 1.2e-19 102.8 Planctomycetes ko:K03086,ko:K03087,ko:K03093 ko02026,ko05111,map02026,map05111 ko00000,ko00001,ko03021 Bacteria 2IY72@203682,COG0568@1,COG0568@2 NA|NA|NA K TIGRFAM RNA polymerase sigma factor, sigma-70 family MAG.T1.179_03244 1123072.AUDH01000001_gene2844 1.1e-45 189.5 Alphaproteobacteria Bacteria 1R87Z@1224,2U45F@28211,COG1082@1,COG1082@2 NA|NA|NA G Xylose isomerase-like TIM barrel MAG.T1.179_03246 420662.Mpe_A1664 4e-57 227.3 unclassified Burkholderiales ssb ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 ko00000,ko00001,ko03029,ko03032,ko03400 Bacteria 1KNFN@119065,1NGYN@1224,2W1PF@28216,COG0629@1,COG0629@2 NA|NA|NA L PFAM single-strand binding protein MAG.T1.179_03247 479435.Kfla_5649 1.1e-34 152.5 Propionibacteriales msrA 1.8.4.11 ko:K07304 ko00000,ko01000 Bacteria 2GJ1S@201174,4DQ8G@85009,COG0225@1,COG0225@2 NA|NA|NA O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine MAG.T1.179_03252 4530.OS06T0114066-00 1.2e-09 69.7 Streptophyta Viridiplantae 2ETCI@1,2SVQU@2759,381HD@33090,3GQZS@35493 NA|NA|NA MAG.T1.179_03253 58123.JOFJ01000005_gene1298 2.3e-30 137.9 Streptosporangiales pflB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006566,GO:0006567,GO:0006629,GO:0006631,GO:0006807,GO:0008150,GO:0008152,GO:0008861,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009987,GO:0016020,GO:0016054,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0016999,GO:0017144,GO:0019541,GO:0019752,GO:0032787,GO:0042737,GO:0043436,GO:0043875,GO:0044237,GO:0044238,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046459,GO:0070689,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.3.1.54 ko:K00656 ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120 R00212,R06987 RC00004,RC01181,RC02742,RC02833 ko00000,ko00001,ko01000 iECH74115_1262.ECH74115_1064,iECIAI39_1322.ECIAI39_2245,iECSP_1301.ECSP_1007,iECs_1301.ECs0986,iEcSMS35_1347.EcSMS35_2218,iEcSMS35_1347.EcSMS35_3410,iG2583_1286.G2583_1138,iSDY_1059.SDY_2358,iZ_1308.Z1248 Bacteria 2GTTT@201174,4EIEU@85012,COG1882@1,COG1882@2 NA|NA|NA C Glycine radical # 2761 queries scanned # Total time (seconds): 56.0060100555 # Rate: 49.30 q/s