# CCycDB Gene Family subCategoryII MAG.C2.12 MAG.T11.11 MAG.T13.20 MAG.T13.85 MAG.T13.59 MAG.T11.14 MAG.T11.1 MAG.T11.24 MAG.T11.25 MAG.T11.56 MAG.T11.59 MAG.T11.77 MAG.T13.83 MAG.T13.71 MAG.T12.46 MAG.T13.57 MAG.T13.60 MAG.T12.69 MAG.T11.57 MAG.T13.90 MAG.T21.39 MAG.T22.36 MAG.T22.49 MAG.T23.24 MAG.T23.71 MAG.T23.60 MAG.T11.72 MAG.T13.29 MAG.T12.26 MAG.T23.20 MAG.T21.70 MAG.T22.48 MAG.T21.30 3-Hydroxypropionate Bicycle 6.0 5.0 8.0 7.0 6.0 20.0 8.0 7.0 8.0 11.0 6.0 9.0 4.0 9.0 8.0 5.0 6.0 7.0 8.0 4.0 9.0 7.0 9.0 4.0 7.0 7.0 5.0 13.0 11.0 12.0 8.0 8.0 8.0 3-Hydroxypropionate/4-Hydroxybutyrate Cycle 4.0 4.0 7.0 5.0 5.0 10.0 7.0 5.0 7.0 5.0 5.0 7.0 5.0 8.0 7.0 4.0 5.0 4.0 7.0 3.0 5.0 4.0 8.0 3.0 4.0 4.0 3.0 7.0 4.0 7.0 6.0 6.0 7.0 ABC transport 12.0 5.0 5.0 4.0 4.0 94.0 4.0 15.0 9.0 31.0 5.0 13.0 9.0 6.0 9.0 21.0 5.0 14.0 9.0 21.0 26.0 17.0 7.0 13.0 3.0 8.0 24.0 50.0 27.0 107.0 16.0 41.0 4.0 ATPase 8.0 9.0 7.0 7.0 6.0 10.0 7.0 7.0 3.0 8.0 7.0 6.0 3.0 8.0 6.0 8.0 10.0 7.0 6.0 4.0 10.0 8.0 8.0 8.0 5.0 4.0 6.0 3.0 8.0 9.0 8.0 2.0 7.0 Aceticlastic methanogenesis 4.0 4.0 6.0 5.0 4.0 19.0 4.0 1.0 3.0 18.0 4.0 8.0 4.0 4.0 5.0 2.0 4.0 3.0 4.0 6.0 11.0 7.0 7.0 5.0 1.0 1.0 2.0 11.0 14.0 4.0 2.0 7.0 4.0 Acetyl-CoA <=> CO, CoA 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Aerobic oxidation 11.0 12.0 12.0 12.0 13.0 30.0 12.0 13.0 14.0 25.0 10.0 13.0 9.0 12.0 13.0 18.0 10.0 11.0 11.0 12.0 25.0 17.0 14.0 12.0 4.0 10.0 12.0 39.0 20.0 37.0 17.0 15.0 13.0 Alcohol 5.0 7.0 7.0 7.0 8.0 15.0 6.0 7.0 4.0 11.0 7.0 9.0 4.0 5.0 5.0 8.0 6.0 8.0 4.0 8.0 6.0 9.0 6.0 6.0 2.0 5.0 8.0 9.0 10.0 13.0 9.0 9.0 4.0 Aliphatic 13.0 9.0 18.0 9.0 14.0 30.0 13.0 14.0 8.0 30.0 18.0 19.0 7.0 16.0 7.0 14.0 7.0 17.0 7.0 21.0 21.0 22.0 18.0 12.0 1.0 7.0 15.0 27.0 21.0 23.0 17.0 22.0 7.0 Alpha-galactans 0.0 0.0 2.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 1.0 0.0 1.0 0.0 0.0 1.0 1.0 0.0 0.0 2.0 2.0 4.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 Aminoglycoside antibotics 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 2.0 0.0 0.0 1.0 0.0 Anaerobic oxidation of methane 5.0 3.0 3.0 2.0 2.0 7.0 1.0 4.0 3.0 3.0 2.0 6.0 5.0 6.0 5.0 5.0 4.0 4.0 5.0 7.0 14.0 7.0 9.0 2.0 1.0 2.0 6.0 27.0 12.0 8.0 8.0 8.0 2.0 Ancillary genes 2.0 1.0 2.0 1.0 1.0 4.0 2.0 1.0 2.0 3.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 2.0 2.0 2.0 1.0 1.0 1.0 0.0 1.0 4.0 2.0 3.0 1.0 1.0 1.0 Anionic 7.0 7.0 10.0 6.0 8.0 12.0 7.0 7.0 6.0 13.0 10.0 7.0 6.0 11.0 6.0 11.0 6.0 11.0 6.0 12.0 6.0 7.0 9.0 11.0 1.0 5.0 9.0 13.0 10.0 11.0 12.0 9.0 7.0 Antibiotic 6.0 6.0 8.0 11.0 9.0 9.0 5.0 5.0 7.0 9.0 7.0 7.0 8.0 7.0 4.0 5.0 5.0 9.0 4.0 4.0 6.0 5.0 5.0 6.0 2.0 6.0 4.0 9.0 6.0 7.0 6.0 9.0 4.0 Arabinan 0.0 0.0 4.0 2.0 0.0 0.0 1.0 2.0 2.0 0.0 2.0 0.0 0.0 3.0 0.0 1.0 1.0 2.0 0.0 0.0 0.0 1.0 3.0 2.0 0.0 1.0 3.0 1.0 0.0 1.0 1.0 1.0 0.0 Arabinose 0.0 0.0 4.0 2.0 0.0 0.0 1.0 2.0 2.0 0.0 2.0 0.0 0.0 3.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 1.0 3.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 0.0 Aromatic 6.0 7.0 7.0 3.0 6.0 13.0 5.0 7.0 2.0 14.0 7.0 5.0 6.0 7.0 2.0 6.0 1.0 8.0 3.0 9.0 6.0 9.0 9.0 5.0 0.0 6.0 4.0 9.0 7.0 7.0 10.0 11.0 1.0 Aromatics 7.0 8.0 12.0 10.0 10.0 35.0 12.0 4.0 8.0 37.0 9.0 16.0 12.0 12.0 10.0 2.0 10.0 1.0 10.0 7.0 19.0 12.0 5.0 4.0 0.0 6.0 3.0 48.0 24.0 26.0 13.0 25.0 11.0 Assimilatory nitrate reduction 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 3.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 2.0 1.0 3.0 1.0 0.0 0.0 Assimilatory sulfate reduction 1.0 3.0 4.0 1.0 1.0 9.0 3.0 6.0 0.0 6.0 5.0 1.0 0.0 3.0 3.0 5.0 1.0 5.0 4.0 4.0 5.0 3.0 4.0 3.0 0.0 0.0 5.0 0.0 3.0 5.0 7.0 2.0 1.0 Auxiliary 3.0 1.0 2.0 3.0 1.0 19.0 2.0 3.0 2.0 7.0 1.0 2.0 2.0 1.0 2.0 5.0 1.0 5.0 1.0 3.0 6.0 0.0 2.0 4.0 0.0 0.0 2.0 9.0 12.0 19.0 4.0 6.0 1.0 Beta-galactans 0.0 0.0 4.0 2.0 0.0 0.0 1.0 2.0 2.0 0.0 2.0 0.0 0.0 3.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 1.0 3.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 0.0 Beta-lactam 0.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Beta-mannan 0.0 0.0 4.0 2.0 0.0 0.0 1.0 2.0 2.0 0.0 2.0 0.0 0.0 3.0 0.0 1.0 1.0 2.0 0.0 0.0 0.0 1.0 3.0 2.0 0.0 1.0 3.0 1.0 0.0 1.0 1.0 1.0 0.0 C4 cycle 1.0 1.0 1.0 1.0 1.0 2.0 0.0 0.0 1.0 1.0 1.0 2.0 1.0 0.0 1.0 2.0 1.0 0.0 1.0 2.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 2.0 2.0 3.0 1.0 1.0 1.0 CO 1.0 0.0 0.0 0.0 2.0 4.0 0.0 1.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 1.0 0.0 2.0 0.0 1.0 0.0 4.0 2.0 1.0 1.0 4.0 0.0 CO, Oxidized ferredoxin <=> CO2, Reduced ferredoxin 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 2.0 1.0 0.0 0.0 0.0 0.0 CO, Quinone <=> CO2, Hydroquinone 0.0 0.0 0.0 0.0 0.0 3.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3.0 0.0 CO2 27.0 23.0 21.0 21.0 23.0 58.0 24.0 20.0 19.0 42.0 20.0 27.0 17.0 26.0 15.0 17.0 18.0 18.0 17.0 20.0 36.0 25.0 31.0 17.0 5.0 15.0 21.0 42.0 27.0 41.0 33.0 48.0 14.0 CO2 <=> carbonic acid 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Calvin cycle 8.0 6.0 5.0 4.0 6.0 15.0 5.0 4.0 5.0 10.0 4.0 6.0 3.0 7.0 4.0 6.0 5.0 6.0 4.0 7.0 15.0 6.0 6.0 6.0 5.0 5.0 5.0 11.0 7.0 13.0 10.0 9.0 5.0 Calvin-Benson-Bassham Cycle 7.0 5.0 5.0 3.0 5.0 12.0 4.0 3.0 4.0 8.0 3.0 4.0 3.0 6.0 4.0 5.0 4.0 5.0 4.0 5.0 13.0 6.0 5.0 6.0 5.0 4.0 5.0 10.0 6.0 11.0 9.0 8.0 5.0 Carbohydrate 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Cationic 13.0 9.0 13.0 5.0 8.0 28.0 8.0 13.0 11.0 34.0 11.0 21.0 4.0 14.0 4.0 14.0 5.0 15.0 4.0 25.0 16.0 26.0 17.0 8.0 0.0 6.0 17.0 27.0 24.0 26.0 17.0 19.0 3.0 Cellulose 0.0 0.0 4.0 2.0 0.0 0.0 1.0 3.0 2.0 0.0 2.0 0.0 0.0 3.0 0.0 1.0 1.0 2.0 0.0 0.0 0.0 1.0 3.0 2.0 0.0 1.0 3.0 1.0 0.0 1.0 1.0 1.0 0.0 Central methanogenic pathway 7.0 2.0 3.0 3.0 2.0 4.0 1.0 2.0 2.0 4.0 1.0 3.0 3.0 2.0 4.0 2.0 2.0 0.0 4.0 3.0 10.0 4.0 8.0 1.0 1.0 0.0 3.0 18.0 8.0 3.0 4.0 6.0 2.0 Chitin 0.0 0.0 4.0 2.0 0.0 0.0 1.0 3.0 2.0 0.0 2.0 0.0 0.0 3.0 0.0 1.0 1.0 2.0 0.0 0.0 0.0 1.0 3.0 2.0 0.0 1.0 3.0 1.0 0.0 1.0 1.0 1.0 0.0 Citrate cycle 8.0 10.0 11.0 10.0 10.0 16.0 10.0 12.0 12.0 11.0 9.0 10.0 8.0 10.0 12.0 10.0 10.0 11.0 11.0 11.0 16.0 10.0 11.0 8.0 7.0 10.0 10.0 16.0 12.0 12.0 18.0 11.0 8.0 Coenzyme 6.0 12.0 10.0 12.0 12.0 15.0 7.0 8.0 7.0 18.0 8.0 8.0 9.0 11.0 8.0 6.0 9.0 6.0 9.0 8.0 12.0 8.0 11.0 5.0 1.0 3.0 8.0 15.0 8.0 7.0 8.0 11.0 6.0 D-Amino acid 1.0 1.0 2.0 1.0 1.0 2.0 3.0 1.0 2.0 6.0 2.0 3.0 1.0 1.0 1.0 1.0 2.0 2.0 1.0 3.0 3.0 2.0 2.0 0.0 0.0 3.0 2.0 4.0 2.0 6.0 2.0 3.0 1.0 DMS synthesis 0.0 0.0 1.0 0.0 0.0 7.0 0.0 0.0 0.0 6.0 1.0 5.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 5.0 4.0 5.0 0.0 4.0 0.0 DMSP demethylation 0.0 0.0 1.0 0.0 0.0 7.0 0.0 0.0 0.0 5.0 0.0 5.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 5.0 4.0 5.0 0.0 4.0 0.0 Denitrification 2.0 3.0 2.0 1.0 1.0 4.0 1.0 2.0 2.0 1.0 1.0 4.0 1.0 4.0 1.0 3.0 2.0 0.0 2.0 4.0 4.0 4.0 2.0 0.0 0.0 2.0 3.0 10.0 5.0 3.0 3.0 4.0 1.0 Diaminononanoate, CO2 <=> Phosphate, Dethiobiotin 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Dicarboxylate/4-hydroxybutyrate cycle 3.0 7.0 8.0 10.0 7.0 11.0 6.0 7.0 8.0 9.0 7.0 8.0 3.0 8.0 7.0 7.0 6.0 7.0 6.0 7.0 14.0 10.0 7.0 5.0 7.0 5.0 7.0 13.0 11.0 8.0 13.0 11.0 6.0 Disaccharide 0.0 0.0 3.0 2.0 0.0 0.0 1.0 0.0 1.0 0.0 2.0 0.0 0.0 2.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Dissimilatory nitrate reduction 1.0 0.0 0.0 0.0 0.0 5.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 2.0 0.0 0.0 2.0 1.0 0.0 5.0 0.0 5.0 0.0 1.0 0.0 0.0 3.0 8.0 2.0 3.0 4.0 4.0 0.0 Dissimilatory sulfur reduction and oxidation 7.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 1.0 1.0 0.0 Fatty acid 16.0 20.0 26.0 26.0 32.0 40.0 21.0 28.0 21.0 51.0 23.0 26.0 27.0 22.0 20.0 24.0 22.0 22.0 21.0 8.0 30.0 23.0 20.0 13.0 12.0 16.0 15.0 35.0 28.0 44.0 29.0 39.0 17.0 Fermentation 3.0 4.0 5.0 4.0 3.0 12.0 3.0 4.0 5.0 10.0 4.0 9.0 2.0 4.0 3.0 5.0 3.0 8.0 3.0 6.0 8.0 4.0 6.0 7.0 2.0 4.0 3.0 17.0 10.0 11.0 4.0 10.0 2.0 Fucose 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 2.0 1.0 0.0 0.0 0.0 0.0 0.0 Galactoarabinan 0.0 1.0 1.0 0.0 1.0 0.0 1.0 0.0 1.0 8.0 1.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 2.0 1.0 1.0 1.0 0.0 0.0 1.0 0.0 2.0 0.0 1.0 2.0 1.0 2.0 Galactose 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Galacturonic acid 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 2.0 0.0 0.0 0.0 Glycan 0.0 0.0 0.0 2.0 1.0 0.0 0.0 1.0 1.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 2.0 1.0 0.0 1.0 1.0 0.0 1.0 0.0 1.0 1.0 0.0 1.0 2.0 2.0 0.0 1.0 Glycolipid 0.0 0.0 0.0 0.0 0.0 3.0 0.0 0.0 0.0 9.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 Glycolysis 15.0 13.0 17.0 16.0 14.0 31.0 12.0 11.0 13.0 39.0 11.0 15.0 10.0 14.0 12.0 13.0 12.0 10.0 11.0 18.0 25.0 18.0 17.0 12.0 7.0 9.0 10.0 20.0 21.0 19.0 13.0 17.0 12.0 Glycopeptide 1.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 2.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 Glyoxylate cycle 1.0 3.0 3.0 4.0 3.0 3.0 2.0 2.0 2.0 3.0 3.0 1.0 2.0 3.0 2.0 2.0 2.0 2.0 2.0 3.0 1.0 2.0 3.0 3.0 2.0 2.0 3.0 3.0 3.0 3.0 4.0 4.0 2.0 Hemicellulose 0.0 0.0 6.0 3.0 0.0 0.0 2.0 2.0 3.0 1.0 2.0 1.0 0.0 3.0 0.0 3.0 1.0 3.0 0.0 0.0 1.0 2.0 4.0 2.0 0.0 1.0 3.0 1.0 0.0 3.0 1.0 1.0 0.0 Herbicide 0.0 0.0 0.0 0.0 0.0 3.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 2.0 0.0 0.0 0.0 2.0 0.0 5.0 4.0 1.0 3.0 1.0 4.0 0.0 Hydrogenotrophic methanogenesis 0.0 0.0 0.0 0.0 0.0 2.0 1.0 1.0 1.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 4.0 1.0 1.0 2.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 0.0 0.0 L-Amino acid 8.0 8.0 8.0 6.0 8.0 16.0 8.0 9.0 6.0 19.0 9.0 14.0 1.0 8.0 2.0 8.0 4.0 6.0 3.0 12.0 10.0 13.0 10.0 6.0 0.0 7.0 8.0 15.0 16.0 14.0 11.0 17.0 2.0 Lignin 22.0 26.0 32.0 30.0 32.0 82.0 31.0 15.0 36.0 69.0 28.0 39.0 28.0 35.0 33.0 16.0 27.0 16.0 26.0 23.0 45.0 30.0 27.0 16.0 7.0 13.0 14.0 97.0 48.0 60.0 23.0 57.0 24.0 Link between inorganic and organic sulfur transformation 3.0 6.0 6.0 6.0 6.0 26.0 5.0 7.0 6.0 10.0 6.0 10.0 2.0 7.0 4.0 6.0 6.0 5.0 3.0 5.0 5.0 6.0 9.0 5.0 0.0 4.0 2.0 13.0 10.0 13.0 3.0 11.0 3.0 Lipoarabinomannan 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Lipopolysaccharide 10.0 14.0 10.0 11.0 12.0 3.0 8.0 7.0 9.0 0.0 8.0 3.0 7.0 10.0 10.0 12.0 12.0 5.0 8.0 2.0 9.0 5.0 7.0 1.0 5.0 4.0 8.0 13.0 15.0 9.0 12.0 15.0 7.0 Mannose 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Methylotrophic methanogenesis 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Monosaccharide 12.0 13.0 18.0 11.0 15.0 28.0 11.0 12.0 10.0 28.0 11.0 16.0 10.0 15.0 10.0 14.0 12.0 16.0 9.0 16.0 21.0 18.0 19.0 8.0 3.0 8.0 13.0 18.0 21.0 33.0 16.0 18.0 11.0 Nitrification 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 Nitrogen fixation 3.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 5.0 0.0 1.0 0.0 0.0 0.0 O-linked 1.0 4.0 7.0 9.0 7.0 3.0 3.0 2.0 6.0 5.0 8.0 3.0 7.0 3.0 6.0 2.0 8.0 3.0 6.0 4.0 1.0 4.0 5.0 3.0 1.0 2.0 1.0 4.0 3.0 5.0 5.0 6.0 4.0 Oligosaccharide 1.0 0.0 2.0 2.0 2.0 1.0 2.0 0.0 2.0 3.0 2.0 2.0 2.0 1.0 2.0 2.0 2.0 2.0 2.0 1.0 0.0 2.0 2.0 0.0 0.0 0.0 1.0 2.0 2.0 2.0 1.0 2.0 2.0 Organic degradation and synthesis 3.0 4.0 6.0 3.0 5.0 14.0 4.0 5.0 4.0 22.0 5.0 9.0 4.0 6.0 4.0 3.0 5.0 4.0 4.0 5.0 9.0 6.0 7.0 5.0 1.0 2.0 7.0 13.0 12.0 16.0 7.0 12.0 4.0 Organic phosphoester hydrolysis 0.0 1.0 1.0 0.0 0.0 1.0 1.0 1.0 0.0 2.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 1.0 1.0 0.0 0.0 3.0 3.0 4.0 1.0 0.0 0.0 0.0 Organic pollutant 4.0 0.0 0.0 1.0 2.0 5.0 1.0 2.0 0.0 8.0 0.0 1.0 0.0 0.0 1.0 3.0 0.0 0.0 0.0 0.0 5.0 1.0 0.0 1.0 0.0 0.0 1.0 18.0 3.0 6.0 2.0 1.0 1.0 Organic sulfur transformation 6.0 9.0 11.0 9.0 8.0 40.0 6.0 12.0 4.0 25.0 9.0 11.0 6.0 9.0 7.0 11.0 5.0 7.0 7.0 9.0 13.0 14.0 13.0 4.0 2.0 3.0 6.0 21.0 16.0 30.0 5.0 17.0 6.0 Others 3.0 1.0 1.0 2.0 3.0 3.0 1.0 1.0 1.0 2.0 2.0 1.0 1.0 1.0 1.0 2.0 2.0 1.0 1.0 0.0 4.0 1.0 1.0 0.0 1.0 2.0 2.0 2.0 2.0 5.0 2.0 1.0 1.0 Oxidation of formaldehyde 0.0 0.0 0.0 0.0 1.0 4.0 0.0 0.0 0.0 2.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 2.0 1.0 0.0 4.0 2.0 0.0 1.0 0.0 0.0 0.0 4.0 3.0 7.0 0.0 1.0 0.0 Oxidation of formate 3.0 0.0 0.0 1.0 0.0 3.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 1.0 0.0 5.0 0.0 0.0 1.0 Oxidation of merthane and C1 compounds 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 16.0 3.0 9.0 0.0 0.0 0.0 Oxidative phosphorylation 37.0 42.0 40.0 37.0 41.0 57.0 16.0 22.0 23.0 40.0 29.0 36.0 13.0 24.0 32.0 31.0 38.0 26.0 31.0 26.0 48.0 38.0 16.0 13.0 19.0 24.0 18.0 48.0 42.0 43.0 38.0 37.0 12.0 Pectin 0.0 0.0 7.0 2.0 0.0 0.0 2.0 3.0 3.0 0.0 2.0 1.0 0.0 3.0 0.0 1.0 1.0 3.0 0.0 0.0 1.0 2.0 4.0 1.0 0.0 1.0 1.0 1.0 0.0 2.0 1.0 1.0 0.0 Pentose phosphate 12.0 8.0 7.0 5.0 9.0 17.0 8.0 7.0 7.0 12.0 7.0 9.0 5.0 10.0 6.0 11.0 7.0 9.0 6.0 10.0 14.0 10.0 13.0 6.0 4.0 7.0 8.0 14.0 11.0 19.0 13.0 11.0 7.0 Pentose phosphate pathway 3.0 2.0 1.0 1.0 3.0 5.0 1.0 2.0 1.0 3.0 1.0 1.0 1.0 2.0 1.0 2.0 1.0 3.0 1.0 1.0 4.0 3.0 4.0 2.0 1.0 2.0 3.0 4.0 3.0 6.0 6.0 3.0 1.0 Peptidoglycan 5.0 5.0 5.0 5.0 5.0 9.0 1.0 5.0 4.0 18.0 4.0 9.0 4.0 5.0 3.0 3.0 6.0 1.0 3.0 4.0 9.0 12.0 5.0 2.0 2.0 4.0 4.0 19.0 9.0 11.0 7.0 8.0 3.0 Phosphonate and phosphinate metabolism 2.0 1.0 1.0 0.0 2.0 3.0 1.0 0.0 1.0 0.0 0.0 1.0 1.0 2.0 2.0 3.0 1.0 0.0 2.0 0.0 2.0 0.0 2.0 1.0 0.0 0.0 1.0 1.0 1.0 4.0 5.0 2.0 1.0 Phosphotransferase system 2.0 0.0 0.0 0.0 0.0 6.0 0.0 4.0 3.0 9.0 0.0 3.0 4.0 0.0 4.0 4.0 0.0 4.0 4.0 7.0 3.0 6.0 0.0 4.0 1.0 3.0 8.0 11.0 5.0 5.0 3.0 10.0 0.0 Photosynthesis proteins 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Photosynthetic electron transport 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Photosynthetic phosphorylation 8.0 9.0 7.0 7.0 6.0 10.0 7.0 7.0 3.0 8.0 7.0 6.0 3.0 8.0 6.0 8.0 10.0 7.0 6.0 4.0 10.0 8.0 8.0 8.0 5.0 4.0 6.0 3.0 8.0 9.0 8.0 2.0 7.0 Photosynthetic pigment 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 3.0 0.0 0.0 0.0 Plastics 0.0 2.0 2.0 0.0 1.0 2.0 1.0 1.0 0.0 3.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 1.0 3.0 0.0 0.0 0.0 1.0 0.0 1.0 4.0 1.0 1.0 0.0 Polyketide 0.0 0.0 0.0 0.0 0.0 2.0 0.0 3.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 3.0 0.0 2.0 0.0 1.0 0.0 Polypeptide antibiotic 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Polysaccharide 0.0 1.0 2.0 1.0 1.0 1.0 0.0 0.0 0.0 2.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 4.0 0.0 2.0 1.0 1.0 0.0 Porphyrin 9.0 5.0 5.0 5.0 6.0 20.0 11.0 11.0 8.0 29.0 5.0 12.0 5.0 6.0 3.0 15.0 4.0 10.0 3.0 13.0 12.0 10.0 13.0 9.0 1.0 3.0 8.0 31.0 16.0 40.0 16.0 13.0 3.0 Protein 1.0 2.0 1.0 1.0 1.0 2.0 1.0 1.0 1.0 4.0 2.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 2.0 1.0 2.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 Purine 22.0 26.0 24.0 22.0 24.0 30.0 20.0 28.0 21.0 39.0 27.0 26.0 27.0 25.0 24.0 23.0 24.0 22.0 23.0 31.0 24.0 29.0 26.0 15.0 3.0 14.0 24.0 32.0 29.0 36.0 28.0 32.0 22.0 Purine metabolism 15.0 20.0 17.0 17.0 20.0 23.0 16.0 20.0 15.0 27.0 18.0 22.0 21.0 19.0 17.0 16.0 19.0 18.0 16.0 23.0 18.0 19.0 18.0 12.0 2.0 12.0 16.0 25.0 21.0 25.0 19.0 24.0 19.0 Pyrimidine 9.0 17.0 13.0 17.0 16.0 19.0 10.0 14.0 15.0 20.0 15.0 17.0 16.0 12.0 15.0 15.0 18.0 13.0 12.0 12.0 15.0 16.0 14.0 9.0 4.0 14.0 12.0 18.0 14.0 20.0 12.0 21.0 10.0 Pyrimidine metabolism 5.0 11.0 9.0 11.0 10.0 10.0 7.0 10.0 11.0 15.0 12.0 12.0 11.0 9.0 11.0 10.0 12.0 9.0 9.0 8.0 10.0 11.0 11.0 7.0 4.0 10.0 8.0 10.0 9.0 11.0 9.0 17.0 8.0 Pyruvate 13.0 11.0 20.0 18.0 14.0 41.0 15.0 16.0 15.0 41.0 13.0 21.0 11.0 19.0 15.0 14.0 12.0 17.0 14.0 17.0 29.0 22.0 21.0 13.0 10.0 11.0 14.0 36.0 27.0 26.0 20.0 25.0 11.0 Pyruvate metabolism 3.0 2.0 4.0 5.0 3.0 5.0 2.0 4.0 3.0 5.0 3.0 3.0 2.0 2.0 2.0 4.0 3.0 3.0 2.0 4.0 3.0 7.0 4.0 2.0 3.0 2.0 4.0 5.0 3.0 4.0 3.0 3.0 3.0 Reductive acetyl-CoA pathway 8.0 2.0 3.0 4.0 5.0 6.0 5.0 4.0 5.0 4.0 3.0 4.0 3.0 3.0 5.0 6.0 3.0 3.0 3.0 5.0 4.0 3.0 4.0 4.0 1.0 4.0 5.0 7.0 4.0 5.0 6.0 2.0 3.0 Reductive tricarboxylic acid cycle 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 2.0 0.0 1.0 0.0 0.0 RuMP pathway 3.0 3.0 4.0 1.0 3.0 5.0 4.0 2.0 3.0 5.0 3.0 2.0 2.0 4.0 3.0 5.0 3.0 1.0 3.0 5.0 4.0 2.0 5.0 2.0 1.0 3.0 1.0 3.0 2.0 4.0 4.0 2.0 4.0 S side-chain 7.0 10.0 7.0 9.0 9.0 28.0 10.0 12.0 9.0 15.0 11.0 17.0 4.0 8.0 6.0 10.0 7.0 10.0 5.0 10.0 7.0 11.0 8.0 9.0 1.0 8.0 8.0 18.0 17.0 15.0 8.0 12.0 5.0 SOX systems 0.0 0.0 0.0 0.0 0.0 11.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 3.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 11.0 0.0 5.0 2.0 7.0 0.0 Se 1.0 3.0 3.0 2.0 2.0 7.0 3.0 4.0 2.0 7.0 3.0 6.0 2.0 2.0 4.0 3.0 2.0 3.0 3.0 4.0 3.0 3.0 2.0 2.0 0.0 2.0 2.0 2.0 4.0 4.0 3.0 4.0 2.0 Secondary metabolite 6.0 6.0 8.0 11.0 9.0 9.0 5.0 5.0 7.0 9.0 7.0 7.0 8.0 7.0 4.0 5.0 5.0 9.0 4.0 4.0 6.0 5.0 5.0 6.0 2.0 6.0 4.0 9.0 6.0 7.0 6.0 9.0 4.0 Selenocompound 3.0 6.0 7.0 5.0 5.0 9.0 7.0 5.0 5.0 11.0 6.0 5.0 2.0 6.0 6.0 4.0 4.0 5.0 5.0 6.0 6.0 8.0 7.0 5.0 1.0 2.0 4.0 2.0 1.0 4.0 5.0 6.0 4.0 Starch 0.0 2.0 7.0 5.0 1.0 2.0 2.0 4.0 2.0 6.0 4.0 0.0 0.0 5.0 0.0 3.0 4.0 5.0 0.0 4.0 5.0 3.0 8.0 4.0 1.0 4.0 4.0 0.0 0.0 4.0 2.0 0.0 0.0 Styrene 0.0 0.0 0.0 0.0 0.0 5.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 2.0 0.0 1.0 0.0 0.0 0.0 4.0 2.0 2.0 0.0 2.0 0.0 Sucrose 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 Sulfur disproportionation 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Sulfur oxidation 0.0 2.0 1.0 1.0 3.0 8.0 1.0 1.0 1.0 9.0 1.0 3.0 1.0 3.0 2.0 0.0 3.0 2.0 3.0 3.0 1.0 3.0 3.0 2.0 0.0 0.0 2.0 10.0 1.0 1.0 3.0 3.0 0.0 Sulfur reduction 2.0 1.0 0.0 0.0 1.0 1.0 2.0 2.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 1.0 1.0 2.0 0.0 0.0 0.0 1.0 2.0 1.0 1.0 0.0 1.0 0.0 Terpenoid 6.0 5.0 5.0 5.0 5.0 5.0 1.0 6.0 2.0 8.0 4.0 6.0 4.0 4.0 4.0 5.0 4.0 3.0 4.0 4.0 5.0 8.0 6.0 4.0 1.0 3.0 5.0 8.0 7.0 10.0 5.0 7.0 3.0 Tetracycline 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Transmembrane transport 2.0 1.0 1.0 1.0 1.0 18.0 1.0 6.0 3.0 11.0 1.0 2.0 5.0 1.0 5.0 6.0 2.0 3.0 5.0 5.0 6.0 6.0 0.0 4.0 1.0 2.0 8.0 9.0 5.0 22.0 7.0 11.0 1.0 Transport system 0.0 1.0 2.0 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 Two-component system 9.0 11.0 12.0 10.0 9.0 36.0 12.0 6.0 9.0 23.0 10.0 9.0 8.0 11.0 8.0 8.0 7.0 7.0 7.0 19.0 14.0 14.0 12.0 5.0 1.0 8.0 13.0 41.0 23.0 39.0 15.0 26.0 7.0 Vancomycin 0.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 2.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 0.0 1.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 1.0 1.0 1.0 1.0 Vitamin A 0.0 0.0 2.0 1.0 1.0 3.0 0.0 1.0 0.0 3.0 0.0 1.0 1.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 2.0 1.0 0.0 0.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 0.0 Vitamin B 40.0 44.0 41.0 48.0 50.0 94.0 45.0 51.0 45.0 105.0 40.0 57.0 40.0 42.0 33.0 50.0 37.0 48.0 30.0 48.0 53.0 50.0 50.0 36.0 9.0 38.0 40.0 114.0 64.0 108.0 67.0 78.0 25.0 Vitamin E 1.0 1.0 1.0 1.0 1.0 6.0 1.0 1.0 1.0 4.0 0.0 5.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 2.0 3.0 0.0 0.0 1.0 0.0 1.0 1.0 1.0 2.0 4.0 1.0 3.0 0.0 Vitamin K 0.0 1.0 1.0 1.0 1.0 1.0 1.0 2.0 0.0 7.0 0.0 1.0 1.0 4.0 0.0 1.0 1.0 0.0 1.0 3.0 2.0 1.0 3.0 0.0 0.0 0.0 2.0 1.0 0.0 0.0 0.0 0.0 1.0 Xylan 0.0 0.0 5.0 2.0 0.0 0.0 2.0 2.0 3.0 0.0 2.0 1.0 0.0 3.0 0.0 1.0 1.0 3.0 0.0 0.0 1.0 2.0 4.0 2.0 0.0 1.0 3.0 1.0 0.0 3.0 1.0 1.0 0.0 Xyloglucan 0.0 0.0 4.0 2.0 0.0 0.0 1.0 3.0 2.0 0.0 2.0 0.0 0.0 3.0 0.0 2.0 1.0 2.0 0.0 0.0 0.0 1.0 3.0 2.0 0.0 1.0 3.0 1.0 0.0 3.0 1.0 1.0 0.0 Xylose-dehydratase 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Xylose-isomerase 0.0 0.0 1.0 0.0 0.0 0.0 0.0 2.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 1.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 beta-amino acid 0.0 2.0 0.0 1.0 1.0 2.0 1.0 2.0 0.0 2.0 1.0 0.0 1.0 0.0 1.0 1.0 1.0 1.0 1.0 4.0 1.0 1.0 1.0 1.0 0.0 0.0 1.0 0.0 0.0 3.0 1.0 1.0 1.0 serine cycle 5.0 9.0 8.0 10.0 9.0 18.0 7.0 10.0 11.0 17.0 7.0 9.0 7.0 8.0 9.0 12.0 7.0 8.0 7.0 7.0 17.0 13.0 9.0 9.0 3.0 7.0 10.0 15.0 12.0 12.0 13.0 12.0 8.0